<110> Hyseq, Inc

<120>  Novel Nucleic Acids and Polypeptides

<130>  21272-045

<140>  NOT YET ASSIGNED
<141>  2001-03-05

<150>  09/693,267
<151>  2000-10-20

<150>  09/665,363
<151>  2000-09-19

<150>  09/616,847
<151>  2000-07-14

<150>  09/596,193
<151>  2000-06-17

<150>  09/574,454
<151>  2000-05-19

<150>  09/519,705
<151>  2000-03-07

<160> 752

      <210> 1
      <211> 1414
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (141)..(1214)

      <400> 1
 tatataaagg gggaggatgg gttttcttct ccttggaagg gggttctatt taaccacttg     60

 cggtttttta aaccttgcga ttggttgtcc tttcccatta aacgcaaatt taataaaaaa    120

 ccccaaacca tttttaaagg    atg ttc aga atg aat ttc atg aag ccc tta     170
                          Met Phe Arg Met Asn Phe Met Lys Pro Leu
                            1               5                  10

 acc cag tgc ata acc gtt ggt cat gaa atg tcg aag gct atc gcc att      218
 Thr Gln Cys Ile Thr Val Gly His Glu Met Ser Lys Ala Ile Ala Ile
                  15                  20                  25

 gcg cag ttt aat gat gac agc ccg aaa gcg agg aaa ata ccc cgg cgc      266
 Ala Gln Phe Asn Asp Asp Ser Pro Lys Ala Arg Lys Ile Pro Arg Arg
              30                  35                  40

 tgg aga ata ggt aaa gca gcg gat tta gtt ggg gtt tct tct cag gct      314
 Trp Arg Ile Gly Lys Ala Ala Asp Leu Val Gly Val Ser Ser Gln Ala
          45                  50                  55

 atc aga gat gcc gag aaa gca ggg cga ctc ccg cac ccg gat atg gaa      362
 Ile Arg Asp Ala Glu Lys Ala Gly Arg Leu Pro His Pro Asp Met Glu
      60                  65                  70

 att cga gga cgg gtt gag caa cgt gtt ggt tat aca att gaa caa att      410
 Ile Arg Gly Arg Val Glu Gln Arg Val Gly Tyr Thr Ile Glu Gln Ile
  75                  80                  85                  90

 aat cat atg cgt cat gtg ttt ggt ccg cga ttg cag cgt gct gaa aac      458
 Asn His Met Arg His Val Phe Gly Pro Arg Leu Gln Arg Ala Glu Asn
                  95                 100                 105

 gta ttt cca ccg gtg ctc ggg gtt gct gcc cat aaa ggt ggc gtt tac      506
 Val Phe Pro Pro Val Leu Gly Val Ala Ala His Lys Gly Gly Val Tyr
             110                 115                 120

 aaa acc tca gtt tct gtt cat ctt gct cag gat ctg gct ctg aag ggg      554
 Lys Thr Ser Val Ser Val His Leu Ala Gln Asp Leu Ala Leu Lys Gly
         125                 130                 135

 cta cgt gtt ttg ctc gtg gaa ggt aac gac ccc cag gga aca gcc tca      602
 Leu Arg Val Leu Leu Val Glu Gly Asn Asp Pro Gln Gly Thr Ala Ser
     140                 145                 150

 atg tat cac gga tgg gta cca gat ctt cat att cat gca gaa gac act      650
 Met Tyr His Gly Trp Val Pro Asp Leu His Ile His Ala Glu Asp Thr
 155                 160                 165                 170

 ctc ctg cct ttc tat ctt ggg gaa aag gac gat gtc act tat gca ata      698
 Leu Leu Pro Phe Tyr Leu Gly Glu Lys Asp Asp Val Thr Tyr Ala Ile
                 175                 180                 185

 aag ccc act tgc tgg ccg ggg ctt gac att att cct tcc tgt ctg gct      746
 Lys Pro Thr Cys Trp Pro Gly Leu Asp Ile Ile Pro Ser Cys Leu Ala
             190                 195                 200

 ctg cac cgt att gaa act gag tta atg ggc aaa ttt gat gaa ggt aaa      794
 Leu His Arg Ile Glu Thr Glu Leu Met Gly Lys Phe Asp Glu Gly Lys
         205                 210                 215

 ctg ccc acc gat cca cac ctg atg ctc cga ctg gcc att gaa act gtt      842
 Leu Pro Thr Asp Pro His Leu Met Leu Arg Leu Ala Ile Glu Thr Val
     220                 225                 230

 gct cat gac tat gat gtc ata gtt att gac agc gcg cct aac ctg ggt      890
 Ala His Asp Tyr Asp Val Ile Val Ile Asp Ser Ala Pro Asn Leu Gly
 235                 240                 245                 250

 atc ggc acg att aat gtc gta tgt gct gct gat gtg ctg att gtt ccc      938
 Ile Gly Thr Ile Asn Val Val Cys Ala Ala Asp Val Leu Ile Val Pro
                 255                 260                 265

 acg cct gct gag ttg ttt gac tac acc tcc gca ctg cag ttt ttc gat      986
 Thr Pro Ala Glu Leu Phe Asp Tyr Thr Ser Ala Leu Gln Phe Phe Asp
             270                 275                 280

 atg ctt cgt gat ctg ctc aag aac gtt gat ctt aaa ggg ttc gag cct     1034
 Met Leu Arg Asp Leu Leu Lys Asn Val Asp Leu Lys Gly Phe Glu Pro
         285                 290                 295

 gat gta cgt att ttg ctt acc aaa tac agc aat agt aat ggc tct cag     1082
 Asp Val Arg Ile Leu Leu Thr Lys Tyr Ser Asn Ser Asn Gly Ser Gln
     300                 305                 310

 tcc ccg tgg atg gag gag caa att cgg gat gcc tgg gga agc atg gtt     1130
 Ser Pro Trp Met Glu Glu Gln Ile Arg Asp Ala Trp Gly Ser Met Val
 315                 320                 325                 330

 cta aaa aat gtt gta cgt gaa acg gat gaa gtt ggt aaa ggt cag atc     1178
 Leu Lys Asn Val Val Arg Glu Thr Asp Glu Val Gly Lys Gly Gln Ile
                 335                 340                 345

 aac aat cat cgc gct acc gga ggc aat ttc cgg ttg tgaa gcggtggtag     1228
 Asn Asn His Arg Ala Thr Gly Gly Asn Phe Arg Leu 
             350                 355

 cggctgccgt tttcgcaacg gcttgcggtg caaaaggcac agccagcatc agggccaggc   1288

 taaataaaga aactcgaaat ttcggcatga tgagcattca gatagtggtt cacgcgcacg   1348

 ggttgcgcac cgccggagta aggatttact gaggctagcg acgccatcat aacgagcaaa   1408

 aagtgc                                                              1414




      <210> 2
      <211> 515
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (9)..(461)

      <400> 2
 ccgccatc atg ggt cgc atg cat gct ccc ggg aag ggc ctg tcc cag tcg      50
          Met Gly Arg Met His Ala Pro Gly Lys Gly Leu Ser Gln Ser
            1               5                  10

 gct tta ccc tat cga cgc agc gtc ccc act tgg ttg aag ttg aca tct       98
 Ala Leu Pro Tyr Arg Arg Ser Val Pro Thr Trp Leu Lys Leu Thr Ser
  15                  20                  25                  30

 gac gac gtg aag gag cag att tac aaa ctg gcc aag aag ggc ctt act      146
 Asp Asp Val Lys Glu Gln Ile Tyr Lys Leu Ala Lys Lys Gly Leu Thr
                  35                  40                  45

 cct tca cag atc ggt gta atc ctg aga gat tca cat ggt gtt gca caa      194
 Pro Ser Gln Ile Gly Val Ile Leu Arg Asp Ser His Gly Val Ala Gln
              50                  55                  60

 gta cgt ttt gtg aca ggc aat aaa att tta aga att ctt aag tct aag      242
 Val Arg Phe Val Thr Gly Asn Lys Ile Leu Arg Ile Leu Lys Ser Lys
          65                  70                  75

 gga ctt gct cct gat ctt cct gaa gat ctc tac cat tta att aag aaa      290
 Gly Leu Ala Pro Asp Leu Pro Glu Asp Leu Tyr His Leu Ile Lys Lys
      80                  85                  90

 gca gtt gct gtt cga aag cat ctt gag agg aac aga aag gat aag gat      338
 Ala Val Ala Val Arg Lys His Leu Glu Arg Asn Arg Lys Asp Lys Asp
  95                 100                 105                 110

 gct aaa ttc cgt ctg att cta ata gag agc cgg att cac cgt ttg gct      386
 Ala Lys Phe Arg Leu Ile Leu Ile Glu Ser Arg Ile His Arg Leu Ala
                 115                 120                 125

 cga tat tat aag acc aag cga gtc ctc cct ccc aat tgg aaa tat gaa      434
 Arg Tyr Tyr Lys Thr Lys Arg Val Leu Pro Pro Asn Trp Lys Tyr Glu
             130                 135                 140

 tca tct aca gcc tct gcc ctg gtc gca taaat ttgtctgtgt actcaagcaa      486
 Ser Ser Thr Ala Ser Ala Leu Val Ala 
         145                 150

 taaaatgatt gtttaactaa aaaaaaaaa                                      515




      <210> 3
      <211> 512
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (26)..(460)

      <400> 3
 gggctggcag cgcggaggcc gcacg  atg cct gga gtt act gta aaa gac gtg      52
                              Met Pro Gly Val Thr Val Lys Asp Val
                                1               5

 aac cag cag gag ttc gtc aga gct ctg gca gcc ttc ctc aaa aag tcc      100
 Asn Gln Gln Glu Phe Val Arg Ala Leu Ala Ala Phe Leu Lys Lys Ser
  10                  15                  20                  25

 ggg aag ctg aaa gtc ccc gaa tgg gtg gat acc gtc aag ctg gcc aag      148
 Gly Lys Leu Lys Val Pro Glu Trp Val Asp Thr Val Lys Leu Ala Lys
                  30                  35                  40

 cac aaa gag ctt gct ccc tac gat gag aac tgg ttc tac acg cga gct      196
 His Lys Glu Leu Ala Pro Tyr Asp Glu Asn Trp Phe Tyr Thr Arg Ala
              45                  50                  55

 gct tcc aca gcg cgg cac ctg tac ctc cgg ggt ggc gct ggg gtt ggc      244
 Ala Ser Thr Ala Arg His Leu Tyr Leu Arg Gly Gly Ala Gly Val Gly
          60                  65                  70

 tcc atg acc aag atc tat ggg gga cgt cag aga aac ggc gtc atg ccc      292
 Ser Met Thr Lys Ile Tyr Gly Gly Arg Gln Arg Asn Gly Val Met Pro
      75                  80                  85

 agc cac ttc agc cga ggc tcc aag agt gtg gcc cgc cgg gtc ctc caa      340
 Ser His Phe Ser Arg Gly Ser Lys Ser Val Ala Arg Arg Val Leu Gln
  90                  95                 100                 105

 gcc ctg gag ggg ctg aaa atg gtg gaa aag gac caa gat ggc ggc cgc      388
 Ala Leu Glu Gly Leu Lys Met Val Glu Lys Asp Gln Asp Gly Gly Arg
                 110                 115                 120

 aaa ctg aca cct cag gga caa aga gat ctg gac aga atc gcc gga cag      436
 Lys Leu Thr Pro Gln Gly Gln Arg Asp Leu Asp Arg Ile Ala Gly Gln
             125                 130                 135

 gtg gca gct gcc aac aag aag cat tagaacaaac catgctgggt taataaattg     490
 Val Ala Ala Ala Asn Lys Lys His 
         140                 145

 cctcattcgt aaaaaaaaaa aa                                             512




      <210> 4
      <211> 2727
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (274)..(2118)

      <400> 4
 tgacgttcca ggagctagtg gcctcttcac cctggtgacc tctgttccgt attctgtcac     60

 tgagagacgc cctgggacat ctgtggtggc ttttgtcgcg ctgggaccta ccctgactac    120

 gggagttggg aggacccggg acaccgcaca gccgggaaat gattgtgcgg cggaaccagt    180

 acaggttcgc agcccaagtc actgcacccg gacgccgagg gctgcagcag aaacggttta    240

 ataggagagg acaccctaga tccgcctccg taa atg gac tca gtg gcc ttt gag     294
                                      Met Asp Ser Val Ala Phe Glu
                                        1               5

 gat gtg gct gtg aac ttc acc cat gag gag tgg gct ttg ctg ggt cca      342
 Asp Val Ala Val Asn Phe Thr His Glu Glu Trp Ala Leu Leu Gly Pro
          10                  15                  20

 tca cag aag aat ctc tac aga gat gtg atg cga gaa acc att agg aac      390
 Ser Gln Lys Asn Leu Tyr Arg Asp Val Met Arg Glu Thr Ile Arg Asn
      25                  30                  35

 ctg aac tgt ata gga atg aaa tgg gaa aac cag aac att gat gat cag      438
 Leu Asn Cys Ile Gly Met Lys Trp Glu Asn Gln Asn Ile Asp Asp Gln
  40                  45                  50                  55

 cac caa aat ctc agg aga aat cca agg tgt gat gtg gta gag aga ttt      486
 His Gln Asn Leu Arg Arg Asn Pro Arg Cys Asp Val Val Glu Arg Phe
                  60                  65                  70

 ggt aaa agt aaa gat ggt agt cag tgt gga gaa acc tta agc cag att      534
 Gly Lys Ser Lys Asp Gly Ser Gln Cys Gly Glu Thr Leu Ser Gln Ile
              75                  80                  85

 cga aat agt att gta aac aag aac act ccc gcc aga gta gat gca tgt      582
 Arg Asn Ser Ile Val Asn Lys Asn Thr Pro Ala Arg Val Asp Ala Cys
          90                  95                 100

 gga agc agt gtg aat gga gaa gtc ata atg ggt cat tca tcc ctg aat      630
 Gly Ser Ser Val Asn Gly Glu Val Ile Met Gly His Ser Ser Leu Asn
     105                 110                 115

 tgc tac atc aga gtt gat act gga cac aaa cac cgg gag tgt cat gaa      678
 Cys Tyr Ile Arg Val Asp Thr Gly His Lys His Arg Glu Cys His Glu
 120                 125                 130                 135

 tat gca gag aag tca tat aca cat aag cag tgt ggg aaa ggc tta agt      726
 Tyr Ala Glu Lys Ser Tyr Thr His Lys Gln Cys Gly Lys Gly Leu Ser
                 140                 145                 150

 tat cgc cac tcc ttt caa aca tgt gaa agg cct cac gct gga aag aaa      774
 Tyr Arg His Ser Phe Gln Thr Cys Glu Arg Pro His Ala Gly Lys Lys
             155                 160                 165

 ccc tat gat tgt aag gaa tgt gga aaa acc ttc agt tct cct gga aac      822
 Pro Tyr Asp Cys Lys Glu Cys Gly Lys Thr Phe Ser Ser Pro Gly Asn
         170                 175                 180

 ctt cga aga cat atg gta gta aaa ggt gga gat gga cct tat aaa tgt      870
 Leu Arg Arg His Met Val Val Lys Gly Gly Asp Gly Pro Tyr Lys Cys
     185                 190                 195

 gaa ttg tgt ggg aaa gcc ttt ttt tgg ccc agt tta tta cgt atg cat      918
 Glu Leu Cys Gly Lys Ala Phe Phe Trp Pro Ser Leu Leu Arg Met His
 200                 205                 210                 215

 gaa aga act cac act gga gag aaa cca tat gaa tgt aag cag tgt tct      966
 Glu Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Ser
                 220                 225                 230

 aaa gcc ttc cct gtt tac agt tcc tat cta aga cat gaa aaa ata cac     1014
 Lys Ala Phe Pro Val Tyr Ser Ser Tyr Leu Arg His Glu Lys Ile His
             235                 240                 245

 act ggg gag aaa ccg tat gaa tgt aag cag tgt tct aaa gcc ttc cct     1062
 Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Ser Lys Ala Phe Pro
         250                 255                 260

 gat tac agt tca tat cta aga cat gaa aga act cac act gga gag aaa     1110
 Asp Tyr Ser Ser Tyr Leu Arg His Glu Arg Thr His Thr Gly Glu Lys
     265                 270                 275

 ccc tac aaa tgt aaa caa tgg ggg aaa gcc ttc agt gtt tcc ggt tcc     1158
 Pro Tyr Lys Cys Lys Gln Trp Gly Lys Ala Phe Ser Val Ser Gly Ser
 280                 285                 290                 295

 ctt cga gta cat gaa aga att cac act gga gag aaa ccc tat aca tgt     1206
 Leu Arg Val His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Thr Cys
                 300                 305                 310

 aaa cag tgt ggg aaa gcg ttt tgt cat ctt gga agc ttt caa aga cac     1254
 Lys Gln Cys Gly Lys Ala Phe Cys His Leu Gly Ser Phe Gln Arg His
             315                 320                 325

 atg ata atg cac agt gga gat gga cct cat aaa tgt aag ata tgt ggg     1302
 Met Ile Met His Ser Gly Asp Gly Pro His Lys Cys Lys Ile Cys Gly
         330                 335                 340

 aaa ggc ttt gat ttt cct ggt tca gca cga att cat gaa gga act cac     1350
 Lys Gly Phe Asp Phe Pro Gly Ser Ala Arg Ile His Glu Gly Thr His
     345                 350                 355

 act cta gag aaa ccc tat gaa tgt aag caa tgt ggg aaa ttg tta tct     1398
 Thr Leu Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Leu Leu Ser
 360                 365                 370                 375

 cat cgc tca agc ttt cga aga cac atg atg gca cac act gga gat ggc     1446
 His Arg Ser Ser Phe Arg Arg His Met Met Ala His Thr Gly Asp Gly
                 380                 385                 390

 cct cat aaa tgc aca gta tgt ggg aaa gcc ttt gat tct cct agt gta     1494
 Pro His Lys Cys Thr Val Cys Gly Lys Ala Phe Asp Ser Pro Ser Val
             395                 400                 405

 ttt caa aga cat gaa agg act cac act gga gag aaa ccc tat gaa tgc     1542
 Phe Gln Arg His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys
         410                 415                 420

 aag caa tgt ggg aaa gcc ttc cgt act tcc agt tcc ctt cga aaa cat     1590
 Lys Gln Cys Gly Lys Ala Phe Arg Thr Ser Ser Ser Leu Arg Lys His
     425                 430                 435

 gaa aca aca cac act gga gag caa ccc tat aaa tgt aaa tgt gga aaa     1638
 Glu Thr Thr His Thr Gly Glu Gln Pro Tyr Lys Cys Lys Cys Gly Lys
 440                 445                 450                 455

 gct ttt agt gat tta ttt tcc ttt caa agt cat gaa aca aca cac agt     1686
 Ala Phe Ser Asp Leu Phe Ser Phe Gln Ser His Glu Thr Thr His Ser
                 460                 465                 470

 gaa gag gag cct tat gaa tgt aag gag tgt ggg aaa gca ttt agt tct     1734
 Glu Glu Glu Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ser Ser
             475                 480                 485

 ttt aaa tac ttt tgt cgc cat gaa agg act cac agt gaa gaa aaa tct     1782
 Phe Lys Tyr Phe Cys Arg His Glu Arg Thr His Ser Glu Glu Lys Ser
         490                 495                 500

 tat gag tgt caa att tgt ggc aaa gcc ttc agt cgt ttc agt tac tta     1830
 Tyr Glu Cys Gln Ile Cys Gly Lys Ala Phe Ser Arg Phe Ser Tyr Leu
     505                 510                 515

 aaa act cat gaa agg act cac acg gca gag aag cca tat gaa tgt aag     1878
 Lys Thr His Glu Arg Thr His Thr Ala Glu Lys Pro Tyr Glu Cys Lys
 520                 525                 530                 535

 caa tgc agg aaa gca ttc ttt tgg ccc tct ttc ctt cta aga cat gaa     1926
 Gln Cys Arg Lys Ala Phe Phe Trp Pro Ser Phe Leu Leu Arg His Glu
                 540                 545                 550

 agg act cac act gga gaa aga ccc tat gaa tgt aaa cac tgt ggt aaa     1974
 Arg Thr His Thr Gly Glu Arg Pro Tyr Glu Cys Lys His Cys Gly Lys
             555                 560                 565

 gcc ttc agt cgt tcc agt ttc tgt cga gaa cat gaa aga act cac act     2022
 Ala Phe Ser Arg Ser Ser Phe Cys Arg Glu His Glu Arg Thr His Thr
         570                 575                 580

 gga gag aag ccc tat gaa tgt aag gaa tgt ggg aaa gcc ttc agt tct     2070
 Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ser Ser
     585                 590                 595

 ctc agt tcc ttt aat aga cat aaa agg aca cac tgg aag gat att cta     2118
 Leu Ser Ser Phe Asn Arg His Lys Arg Thr His Trp Lys Asp Ile Leu 
 600                 605                 610                 615

 taagtgtatg gaatgtggga aagcattcat tggttttatc acattcagat acttgaaaga   2178

 aataaatcct gtgaatgtaa acgtggtaaa gccttaagaa gtttccaggc tgggcgcagc   2238

 ggctcacacc tgtaatccca gcactttgag aggccgagga gggcagatca cgaggccagg   2298

 agatcgagac cagcctggct aacatgggaa accctgtctc tactaaaaat acggaaaaaa   2358

 aaaaaaatag ccaggcatag ttgctcacac ctgtagtcct agctactcag gaggctgagg   2418

 caggagaatc ccttgaaccc gggaggtgga ggttgcagtg agccgagatt gcactactgc   2478

 actccagctt gggtgctaga gcgagactcc atctcaaaaa aaaaaaaaaa agtttccatt   2538

 tctttcaaat agagttgctg cctgctatat gcaagaagat tggttccagt acaccctgag   2598

 tatacctaaa tccacagatg ccagctcttt tataaaatgg aatattcgca tgtacctacc   2658

 cacattctcc tgtatactct ataaatgtct agattaatta aaatatctca tgcattgtaa   2718

 aaaaaaaaa                                                           2727




      <210> 5
      <211> 1898
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (52)..(654)

      <400> 5
 gacgcggagc agagtcgact gggagcgacc gagcgggccg ccgccgccgc c atg aac      57
                                                          Met Asn
                                                            1

 ccc gaa tat gac tac ctg ttt aag ctg ctt ttg att ggc gac tca ggc      105
 Pro Glu Tyr Asp Tyr Leu Phe Lys Leu Leu Leu Ile Gly Asp Ser Gly
           5                  10                  15

 gtg ggc aag tca tgc ctg ctc ctg cgg ttt gct gat gac acg tac aca      153
 Val Gly Lys Ser Cys Leu Leu Leu Arg Phe Ala Asp Asp Thr Tyr Thr
      20                  25                  30

 gag agc tac atc agc acc atc ggg gtg gac ttc aag atc cga acc atc      201
 Glu Ser Tyr Ile Ser Thr Ile Gly Val Asp Phe Lys Ile Arg Thr Ile
  35                  40                  45                  50

 gag ctg gat ggc aaa act atc aaa ctt cag atc tgg gac aca gcg ggc      249
 Glu Leu Asp Gly Lys Thr Ile Lys Leu Gln Ile Trp Asp Thr Ala Gly
                  55                  60                  65

 cag gaa cgg ttc cgg acc atc act tcc agc tac tac cgg ggg gct cat      297
 Gln Glu Arg Phe Arg Thr Ile Thr Ser Ser Tyr Tyr Arg Gly Ala His
              70                  75                  80

 ggc atc atc gtg gtg tat gac gtc act gac cag gaa tcc tac gcc aac      345
 Gly Ile Ile Val Val Tyr Asp Val Thr Asp Gln Glu Ser Tyr Ala Asn
          85                  90                  95

 gtg aag cag tgg ctg cag gag att gac cgc tat gcc agc gag aac gtc      393
 Val Lys Gln Trp Leu Gln Glu Ile Asp Arg Tyr Ala Ser Glu Asn Val
     100                 105                 110

 aat aag ctc ctg gtg ggc aac aag agc gac ctc acc acc aag aag gtg      441
 Asn Lys Leu Leu Val Gly Asn Lys Ser Asp Leu Thr Thr Lys Lys Val
 115                 120                 125                 130

 gtg gac aac acc aca gcc aag gag ttt gca gac tct ctg ggc atc ccc      489
 Val Asp Asn Thr Thr Ala Lys Glu Phe Ala Asp Ser Leu Gly Ile Pro
                 135                 140                 145

 ttc ttg gag acg agc gcc aag aat gcc acc aat gtc gag cag gcg ttc      537
 Phe Leu Glu Thr Ser Ala Lys Asn Ala Thr Asn Val Glu Gln Ala Phe
             150                 155                 160

 atg acc atg gct gct gaa atc aaa aag cgg atg ggg cct gga gca gcc      585
 Met Thr Met Ala Ala Glu Ile Lys Lys Arg Met Gly Pro Gly Ala Ala
         165                 170                 175

 tct ggg ggc gag cgg ccc aat ctc aag atc gac agc acc cct gta aag      633
 Ser Gly Gly Glu Arg Pro Asn Leu Lys Ile Asp Ser Thr Pro Val Lys
     180                 185                 190

 ccg gct ggc ggt ggc tgt tgc ta ggaggggcac atggagtggg acaggagggg      686
 Pro Ala Gly Gly Gly Cys Cys 
 195                 200

 gcaccttctc cagatgatgt ccctggaggg ggcaggaggt acctccctct ccctctcctg    746

 gggcatttga gtctgtggct ttggggtgtc ctgggctccc catctccttc tggcccatct    806

 gcctgctgcc ctgagccccg gttctgtcag ggtccctaag ggaggacact cagggcctgt    866

 ggccaggcag ggcggaggcc tgctgtgctg ttgcctctag gtgactttcc aagatgcccc    926

 cctacacacc tttctttgga acgagggctc ttctgtcggt gtccctccca cccccatgta    986

 tgctgcactg ggttctctcc ttcttcttcc tgctgtcctg cccaagaact gagggtctcc   1046

 ccggcctcta ctgccctggc tgcagtcagt gcccagggcg aggaatgtgg ccaggggatc   1106

 caggacctgg gatccagggc cctgggctgg acctcaggac aggcatggag gccacagggg   1166

 cccagcagcc caccctttcc tctccccact gcctcctctc ccttcctaca ctcccagctc   1226

 gagccgtcca gctgcggtgg gatctgagta tatctagggc gggtgggcgg gtagcagtgc   1286

 tgggcctgtg tcttgagcct ggagggagtc tgctcctgcc gccctctgcc ctgccagaga   1346

 cagacccatg cgctgcctgc ccaccgtgcc cctttgtccc catgtcaggc ggaggcggaa   1406

 ggcccaccgt gccagaggct gggcaccagc cttaaccctc actctgctag cacctcctcc   1466

 ctttccccaa ggtagcacat ctggctcact ccccactccg tctctggagc ccaccaggga   1526

 aggccctcat cccctgccgc tacttctctg gggaatgtgg gttccatcca ggattggggg   1586

 cctctctgct cacccactct gcacccagga tcctagtccc ctgccctctg gcacagctgc   1646

 ttcctgcaag aaagcaagtc tttggtctcc ctgagaagcc atgtccctcg tgctgtctct   1706

 tgcctgtccc acctgtgccc tgccctccag cttgtattta agtccctggg ctgccccctt   1766

 ggggtgcccc ccgctcccag gttcccctct ggtgtcatgt caggcatttt gcaaggaaaa   1826

 gccacttggg gaaagatgga aaaggacaaa aaaaattaat aaatttccat tggccctcgg   1886

 aaaaaaaaaa aa                                                       1898




      <210> 6
      <211> 2707
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (96)..(2093)

      <400> 6
 aggatcccct gtaacaggct gatgctgagg acctccttga ctccttcctt agcaacattc     60

 tacaggactg cagacaccac ctgtgtgaac cggac   atg aaa ctg gtg tgg cct     113
                                          Met Lys Leu Val Trp Pro
                                            1               5

 agt gcc aag ctg ttg cag gca gct gca ggt gca tct gcc cgg gcc tgt      161
 Ser Ala Lys Leu Leu Gln Ala Ala Ala Gly Ala Ser Ala Arg Ala Cys
              10                  15                  20

 gac tct gac acc agc aat gta ccg cct tta ctg ctg gaa cag ttc cgc      209
 Asp Ser Asp Thr Ser Asn Val Pro Pro Leu Leu Leu Glu Gln Phe Arg
          25                  30                  35

 aag cac agt cag agc agc cag cgg cgg aca atc ctt gaa atg ctc ctg      257
 Lys His Ser Gln Ser Ser Gln Arg Arg Thr Ile Leu Glu Met Leu Leu
      40                  45                  50

 ggt ttc ttg aag ctg cag cag aaa tgg agc tat gaa gac aaa gat caa      305
 Gly Phe Leu Lys Leu Gln Gln Lys Trp Ser Tyr Glu Asp Lys Asp Gln
  55                  60                  65                  70

 agg cct ctg aat ggc ttc aag gac cag ctg tgc tca ctg gta ttc atg      353
 Arg Pro Leu Asn Gly Phe Lys Asp Gln Leu Cys Ser Leu Val Phe Met
                  75                  80                  85

 gct cta aca gac ccc agc acc cag ctt cag ctt gtt ggc atc cgt aca      401
 Ala Leu Thr Asp Pro Ser Thr Gln Leu Gln Leu Val Gly Ile Arg Thr
              90                  95                 100

 ctg aca gtc ttg ggt gcc cag cca gat ctc cta tct tat gag gac ttg      449
 Leu Thr Val Leu Gly Ala Gln Pro Asp Leu Leu Ser Tyr Glu Asp Leu
         105                 110                 115

 gag ctg gca gtg ggt cac ctg tac aga ctg agc ttc ctg aag gag gat      497
 Glu Leu Ala Val Gly His Leu Tyr Arg Leu Ser Phe Leu Lys Glu Asp
     120                 125                 130

 tcc cag agt tgc agg gtg gca gca ctg gaa gca tca gga acc ctg gct      545
 Ser Gln Ser Cys Arg Val Ala Ala Leu Glu Ala Ser Gly Thr Leu Ala
 135                 140                 145                 150

 gct ctc tac cct gtg gcc ttc agc agc cac ctc gta ccc aag ctc gct      593
 Ala Leu Tyr Pro Val Ala Phe Ser Ser His Leu Val Pro Lys Leu Ala
                 155                 160                 165

 gag gag ctg cgt gta ggg gag tca aat ttg act aac gga gat gag ccc      641
 Glu Glu Leu Arg Val Gly Glu Ser Asn Leu Thr Asn Gly Asp Glu Pro
             170                 175                 180

 acc caa tgc tcc cgg cat ctg tgc tgt ctg caa gcc ttg tca gct gta      689
 Thr Gln Cys Ser Arg His Leu Cys Cys Leu Gln Ala Leu Ser Ala Val
         185                 190                 195

 tca aca cat ccc agc atc gtc aag gag aca ctg cct ctg ctg ctg cag      737
 Ser Thr His Pro Ser Ile Val Lys Glu Thr Leu Pro Leu Leu Leu Gln
     200                 205                 210

 cat ctc tgg caa gtg aac aga ggg aat atg gtt gca caa tcc agt gac      785
 His Leu Trp Gln Val Asn Arg Gly Asn Met Val Ala Gln Ser Ser Asp
 215                 220                 225                 230

 gtt att gct gtc tgt cag agc ctc aga cag atg gca gaa aaa tgt cag      833
 Val Ile Ala Val Cys Gln Ser Leu Arg Gln Met Ala Glu Lys Cys Gln
                 235                 240                 245

 cag gac cct gag agt tgc tgg tat ttc cac cag aca gct ata cct tgc      881
 Gln Asp Pro Glu Ser Cys Trp Tyr Phe His Gln Thr Ala Ile Pro Cys
             250                 255                 260

 ctg ctt gcc ttg gct gtg cag gcc tct atg cca gag aag gag ccc tca      929
 Leu Leu Ala Leu Ala Val Gln Ala Ser Met Pro Glu Lys Glu Pro Ser
         265                 270                 275

 gtt ctg aga aaa gta cta ttg gag gat gag gtg ttg gct gcc atg gtg      977
 Val Leu Arg Lys Val Leu Leu Glu Asp Glu Val Leu Ala Ala Met Val
     280                 285                 290

 tct gtc att ggc act gct aca acc cac ctg agc cct gag tta gct gcc     1025
 Ser Val Ile Gly Thr Ala Thr Thr His Leu Ser Pro Glu Leu Ala Ala
 295                 300                 305                 310

 cag agt gtg aca cac att gtg ccc ctc ttc ttg gat ggc aac gtg tcc     1073
 Gln Ser Val Thr His Ile Val Pro Leu Phe Leu Asp Gly Asn Val Ser
                 315                 320                 325

 ttt ctg cct gaa aac agc ttc ccg agc aga ttc cag cca ttc cag gat     1121
 Phe Leu Pro Glu Asn Ser Phe Pro Ser Arg Phe Gln Pro Phe Gln Asp
             330                 335                 340

 ggc tcc tca ggg cag agg cgg ctg att gca ctg ctt atg gcc ttt gtc     1169
 Gly Ser Ser Gly Gln Arg Arg Leu Ile Ala Leu Leu Met Ala Phe Val
         345                 350                 355

 tgc tcc ctg cct cga aat gtg gaa atc cct cag ctg aac caa ctc atg     1217
 Cys Ser Leu Pro Arg Asn Val Glu Ile Pro Gln Leu Asn Gln Leu Met
     360                 365                 370

 cgg gag ctt ttg gaa ctg agc tgc tgc cac agc tgc ccc ttt tct tcc     1265
 Arg Glu Leu Leu Glu Leu Ser Cys Cys His Ser Cys Pro Phe Ser Ser
 375                 380                 385                 390

 acc gct gct gcc aag tgc ttt gca gga ctc ctc aac aag cac cct gca     1313
 Thr Ala Ala Ala Lys Cys Phe Ala Gly Leu Leu Asn Lys His Pro Ala
                 395                 400                 405

 ggg cag cag ctg gat gaa ttc cta cag cta gct gtg gac aaa gtg gag     1361
 Gly Gln Gln Leu Asp Glu Phe Leu Gln Leu Ala Val Asp Lys Val Glu
             410                 415                 420

 gct ggc ctg gac tct ggg ccc tgt cgt agt cag gcc ttc act ctt ctt     1409
 Ala Gly Leu Asp Ser Gly Pro Cys Arg Ser Gln Ala Phe Thr Leu Leu
         425                 430                 435

 ctc tgg gta aca aag gcc cta gtg ctc aga tac cat cct ctc agc tcc     1457
 Leu Trp Val Thr Lys Ala Leu Val Leu Arg Tyr His Pro Leu Ser Ser
     440                 445                 450

 tgc ctt aca gcc cgg ctc atg ggc ctc ctg agt gac cca gaa tta ggt     1505
 Cys Leu Thr Ala Arg Leu Met Gly Leu Leu Ser Asp Pro Glu Leu Gly
 455                 460                 465                 470

 cca gca gca gct gat ggc ttc tct ctg ctc atg tct gac tgc act gat     1553
 Pro Ala Ala Ala Asp Gly Phe Ser Leu Leu Met Ser Asp Cys Thr Asp
                 475                 480                 485

 gtg ctg act cgt gct ggc cat gcc gaa gtg cgg atc atg ttc cgc cag     1601
 Val Leu Thr Arg Ala Gly His Ala Glu Val Arg Ile Met Phe Arg Gln
             490                 495                 500

 cgg ttc ttc aca gat aat gtg cct gct ttg gtc cag ggc ttc cat gct     1649
 Arg Phe Phe Thr Asp Asn Val Pro Ala Leu Val Gln Gly Phe His Ala
         505                 510                 515

 gct ccc caa gat gtg aag cca aac tac ttg aag ggt ctt tct cat gta     1697
 Ala Pro Gln Asp Val Lys Pro Asn Tyr Leu Lys Gly Leu Ser His Val
     520                 525                 530

 ctt aac agg ctg ccc aag cct gta ctc ttg cca gag ctg ccc acg ctt     1745
 Leu Asn Arg Leu Pro Lys Pro Val Leu Leu Pro Glu Leu Pro Thr Leu
 535                 540                 545                 550

 ctt tcc ttg ctg ctg gag gcc ctg tcc tgc cct gac tgt gtg gtg cag     1793
 Leu Ser Leu Leu Leu Glu Ala Leu Ser Cys Pro Asp Cys Val Val Gln
                 555                 560                 565

 ctc tcc acc ctc agc tgc ctt cag cct ctt cta ctg gaa gca ccc caa     1841
 Leu Ser Thr Leu Ser Cys Leu Gln Pro Leu Leu Leu Glu Ala Pro Gln
             570                 575                 580

 gtc atg agt ctt cac gtg gac acc ctc gtc acc aag ttt ctg aac ctc     1889
 Val Met Ser Leu His Val Asp Thr Leu Val Thr Lys Phe Leu Asn Leu
         585                 590                 595

 agc tct agc cct tcc atg gct gtc cgg atc gcc gca ctg cag tgc atg     1937
 Ser Ser Ser Pro Ser Met Ala Val Arg Ile Ala Ala Leu Gln Cys Met
     600                 605                 610

 cat gct ctc act cgc ctg ccc acc cct gtg ctg ctg ccg tac aaa cca     1985
 His Ala Leu Thr Arg Leu Pro Thr Pro Val Leu Leu Pro Tyr Lys Pro
 615                 620                 625                 630

 cag gtg att cgg gcc tta gcc aaa ccc ctg gat gac aag aag aga ctg     2033
 Gln Val Ile Arg Ala Leu Ala Lys Pro Leu Asp Asp Lys Lys Arg Leu
                 635                 640                 645

 gtg cgc aag gaa gca gtg tca gcc aga ggg gag tgg ttt ctg ttg ggg     2081
 Val Arg Lys Glu Ala Val Ser Ala Arg Gly Glu Trp Phe Leu Leu Gly
             650                 655                 660

 agc cct ggc agc tga gccctcagtc ctggcctaga ctgttctgac aatctaacct     2136
 Ser Pro Gly Ser 
         665

 gggattacta actgttgagc catcttcccc aaagcaggga aaccactggt ctctgactgc   2196

 ctttcccaca gacacagcac aaatgctagg cctctgttgc atggctgtac aaagaacata   2256

 agagtccata tttctagtgg atttgtaaaa taagtgtgtg tgagacactt gcgtttgaag   2316

 aaagatctag ggtcctgggt ctcttgcatt tatatgtcag aaaaggggcg atatgctgct   2376

 gaggggtgag tgcatatgag tgtggccctg aggaccaggg ctggcagatg ttgtctacct   2436

 gctgaagaat aaagatttct tttggtaatg gggctgtcag atatttcccc caccccacat   2496

 atgcctcata taaccagagg catcactgga ataacaatga cagggattgg ccaaaaattt   2556

 ttcagggtaa ccaggacagt agcacatgcc tgtaacccca acacttcagg agtctgaggc   2616

 aggcggatca cttgaggcta ggagtttgag actagccctg gcagtatagc aagaacccat   2676

 ctctacaaat aattaaaaaa aaaaaaaaaa g                                  2707




      <210> 7
      <211> 1711
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (132)..(1175)

      <400> 7
 gaccgttccg gcggccattg cgaaaacttc cccacggcta ctgcgtccac gtggcggtgg     60

 cgtggggact ccctgaaagc agagcggcag ggcgcccgga agtcgtgagt cgagtcttcc    120

 cgggctaatc c atg ccg ggt tgg agg ctg ctg acg cag gtc ggc gcc cag     170
              Met Pro Gly Trp Arg Leu Leu Thr Gln Val Gly Ala Gln
                1               5                  10

 gtg ctg ggt cga ctc ggg gac ggc ctg ggt gct gcc ctg ggc ccg ggg      218
 Val Leu Gly Arg Leu Gly Asp Gly Leu Gly Ala Ala Leu Gly Pro Gly
      15                  20                  25

 aac aga aca cac atc tgg ctt ttt gtt aga ggt ctt cat gga aag agt      266
 Asn Arg Thr His Ile Trp Leu Phe Val Arg Gly Leu His Gly Lys Ser
  30                  35                  40                  45

 ggt aca tgg tgg gat gag cat ctt tct gaa gaa aat gtc cca ttc att      314
 Gly Thr Trp Trp Asp Glu His Leu Ser Glu Glu Asn Val Pro Phe Ile
                  50                  55                  60

 aag cag ttg gtc tct gat gaa gat aaa gcc caa tta gca agt aaa ctg      362
 Lys Gln Leu Val Ser Asp Glu Asp Lys Ala Gln Leu Ala Ser Lys Leu
              65                  70                  75

 tgt cct ctg aaa gat gaa cca tgg cct ata cat cct tgg gaa cca ggt      410
 Cys Pro Leu Lys Asp Glu Pro Trp Pro Ile His Pro Trp Glu Pro Gly
          80                  85                  90

 tcc ttt aga gtt ggt ctt att gcc ttg aag ctg ggc atg atg cct tta      458
 Ser Phe Arg Val Gly Leu Ile Ala Leu Lys Leu Gly Met Met Pro Leu
      95                 100                 105

 tgg acc aag gat ggt caa aag cat gtg gtc aca tta ctt cag gta caa      506
 Trp Thr Lys Asp Gly Gln Lys His Val Val Thr Leu Leu Gln Val Gln
 110                 115                 120                 125

 gac tgt cat gtc tta aaa tat acg tca aag gaa aac tgt aat gga aaa      554
 Asp Cys His Val Leu Lys Tyr Thr Ser Lys Glu Asn Cys Asn Gly Lys
                 130                 135                 140

 atg gca acc ctg tct gta gga gga aaa act gta tca cgt ttt cgt aaa      602
 Met Ala Thr Leu Ser Val Gly Gly Lys Thr Val Ser Arg Phe Arg Lys
             145                 150                 155

 gct aca tcc ata ttg gaa ttt tac cgg gaa ctt gga ttg ccg ccg aaa      650
 Ala Thr Ser Ile Leu Glu Phe Tyr Arg Glu Leu Gly Leu Pro Pro Lys
         160                 165                 170

 cag aca gtt aaa atc ttt aat ata aca gat aat gct gca att aaa cca      698
 Gln Thr Val Lys Ile Phe Asn Ile Thr Asp Asn Ala Ala Ile Lys Pro
     175                 180                 185

 ggc act cct ctt tat gct gct cac ttt cgt cca gga cag tat gtg gat      746
 Gly Thr Pro Leu Tyr Ala Ala His Phe Arg Pro Gly Gln Tyr Val Asp
 190                 195                 200                 205

 gtc aca gcc aaa act att ggt aaa ggt ttt caa ggt gtc atg aaa aga      794
 Val Thr Ala Lys Thr Ile Gly Lys Gly Phe Gln Gly Val Met Lys Arg
                 210                 215                 220

 tgg gga ttt aaa ggc cag cct gct acg cat ggt caa acg aaa acc cac      842
 Trp Gly Phe Lys Gly Gln Pro Ala Thr His Gly Gln Thr Lys Thr His
             225                 230                 235

 agg aga cct gga gct gtt gca act ggt gat att ggc aga gtc tgg cct      890
 Arg Arg Pro Gly Ala Val Ala Thr Gly Asp Ile Gly Arg Val Trp Pro
         240                 245                 250

 gga act aaa atg cct gga aaa atg gga aac ata tac agg aca gaa tat      938
 Gly Thr Lys Met Pro Gly Lys Met Gly Asn Ile Tyr Arg Thr Glu Tyr
     255                 260                 265

 gga ctg aaa gtg tgg aga ata aac aca aag cac aac ata atc tat gta      986
 Gly Leu Lys Val Trp Arg Ile Asn Thr Lys His Asn Ile Ile Tyr Val
 270                 275                 280                 285

 aat ggc tct gta cct gga cat aaa aat tgc tta gta aag gtc aaa gat     1034
 Asn Gly Ser Val Pro Gly His Lys Asn Cys Leu Val Lys Val Lys Asp
                 290                 295                 300

 tct aaa ctg cct gca tat aag gat ctc ggt aaa aat cta cca ttc cct     1082
 Ser Lys Leu Pro Ala Tyr Lys Asp Leu Gly Lys Asn Leu Pro Phe Pro
             305                 310                 315

 aca tat ttt cct gat gga gat gaa gag gaa ctg cca gaa gat ttg tat     1130
 Thr Tyr Phe Pro Asp Gly Asp Glu Glu Glu Leu Pro Glu Asp Leu Tyr
         320                 325                 330

 gat gaa aac gtg tgt cag ccc ggt gcg cct tct att aca ttt gcc taa     1178
 Asp Glu Asn Val Cys Gln Pro Gly Ala Pro Ser Ile Thr Phe Ala 
     335                 340                 345

 catctttgga cgtggcagaa ccttacatat tctgtgagct tcgatgagcc agagtgatat   1238

 cataaccacc agaaatcata ctctcctttc ttagtcacaa caaaatcaca catgtcatct   1298

 ttgtcaaggg cataaatata tcattcatac ccccattaaa ttttgttaga aaaattacca   1358

 cattaaatat atgagttaag tagattggat ttgctgaaat tggtgttggg catattagca   1418

 aaatattctt aatttgtgga ctcgattctt ttttactaca tatttcccaa gttatcttaa   1478

 gatgtctgta aatttaactt ttattaaagt tttgtcaatc tttgtgaaat agtggttgtg   1538

 gaacagtaga aaaccatatg gggactatag tgcaacctat ttgggtaaag aaaccatttg   1598

 ctaaaatgga gaaagtaaat agatttttat ttaaattaca gaaacatgtt aaaggccgga   1658

 caaaggaaag acaataaaat cataaattat cggtcctgtt taaaaaaaaa aaa          1711




      <210> 8
      <211> 1913
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (541)..(951)

      <400> 8
 taagcttgcg gccgcaattt tttttttttt tttttccctc aaacaagaag ggcttccttt     60

 aatagacttt aatatagctc atttacaatc gtatgaaaat ccatcaagat caatcatgtt    120

 gcacaatccc taaaggataa aactgaggga agtcatggat aattttcaca gcttcattgt    180

 aaagtccaag atcaaaagga tggctatctt ctttaaactg gacataagat gtacacaaga    240

 tggtggcctt ggcggttact cttccaacca cttccacaat tccagagatt tcttcatcaa    300

 ggggttccat caactcgatg gttccatttt ttccttctcc atctgaaaga ataaacattt    360

 ttccggtggg atgaatcttt ctgcgatcac aggattcccg gcggtgactt gaccccggaa    420

 gtggggtgtg aagctccggt gctggtgcgg cgggggactg cggggccagc ctcagtacca    480

 gcagcagcag cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca    540
                                                                 
 atg ttt cac ttc ttc aga aag cct ccg gaa tct aaa aag ccc tca gta      588
 Met Phe His Phe Phe Arg Lys Pro Pro Glu Ser Lys Lys Pro Ser Val
   1               5                  10                  15

 cca gag aca gaa gca gat gga ttc gtc ctt tta gga gat aca aca gat      636
 Pro Glu Thr Glu Ala Asp Gly Phe Val Leu Leu Gly Asp Thr Thr Asp
              20                  25                  30

 gag caa aga atg aca gca aga ggc aaa act tcg gac ata gag gcc aac      684
 Glu Gln Arg Met Thr Ala Arg Gly Lys Thr Ser Asp Ile Glu Ala Asn
          35                  40                  45

 caa cct ttg gag acc aac aaa gaa aat tca tcc agt gtg act gta tca      732
 Gln Pro Leu Glu Thr Asn Lys Glu Asn Ser Ser Ser Val Thr Val Ser
      50                  55                  60

 gac cct gag atg gaa aat aag gca ggc cag act ctg gag aac agc tca      780
 Asp Pro Glu Met Glu Asn Lys Ala Gly Gln Thr Leu Glu Asn Ser Ser
  65                  70                  75                  80

 tta atg gcc gag ctc ctg agc gat gtg ccg ttc acc ctg gcc ccg cat      828
 Leu Met Ala Glu Leu Leu Ser Asp Val Pro Phe Thr Leu Ala Pro His
                  85                  90                  95

 gtg ctg gca gta cag ggc acc atc act gac ctt ccc gac cac tta ctc      876
 Val Leu Ala Val Gln Gly Thr Ile Thr Asp Leu Pro Asp His Leu Leu
             100                 105                 110

 tcc tat gat ggc agc gaa aac tta tca cgg ttt tgg tat gat ttc act      924
 Ser Tyr Asp Gly Ser Glu Asn Leu Ser Arg Phe Trp Tyr Asp Phe Thr
         115                 120                 125

 ctt gaa aat tca gtg ctc tgt gat tca taacc tttatgtctg tttgcacctt      976
 Leu Glu Asn Ser Val Leu Cys Asp Ser 
     130                 135

 aacagcttta aaatatgttc gcctatttta tctaacctgt ttgatgttct ttgccgtttc   1036

 actgtttaag gtcctcagca aggatcataa agcaaagaaa atagcattat gttcactact   1096

 ctatttttaa gaaaaaggta catttgtata caaattgaac ttaagttcca cttcctttct   1156

 cccatataat aaatatacaa attaggctat gaaggtttta ggaaaggact cgattccttc   1216

 agatggtctc tcaaaatata acacctcaaa tttatcttag aagaactgtg aaaaagaatt   1276

 gtggcatttt tcagtcacta cagctccgaa gtctgagcaa gaagtgggtg tgaagtctcc   1336

 tctctggttt gtaggaagtt gaattagtgt tattcctgca tttttttctt ccacagtgtt   1396

 tatgaatgaa ttcagaaaaa aagttgccag ttagcttaat ttcttcagat gcattgatgt   1456

 ggaaatttaa aacttgtcct aaacagcagt gctagtttgc tgatacaagg atgctagacc   1516

 tgctctgcgt gctctttctg gagtggccca tttcggtttt ctgaaaccca tggcagccct   1576

 ttccatcgtg aataatcgtt gtgttcccac ctttgttctc tgcctttttg ctacttcagt   1636

 gtgctctctg accagctttc caaagaactt tccctgcttc tgcctcggtt gccatttgct   1696

 ctccttacca catatgttcc cagtttatga agagatccac atttcctttc aacccctctg   1756

 cctcctgaag aaaaacatct catgatgata catattattg ctgataacac ccttatttag   1816

 aaatttgttg gccacaatac agatggaaat gttttactgc tggaaaactg aaatcaactc   1876

 atttccaatt agagtatagg cagaacacct agatatg                            1913




      <210> 9
      <211> 3807
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (81)..(3569)

      <400> 9
 cggtgaaggt gcaggcccgg ccccgccact gccgcagcca ggagatggtt cgggcctagc     60

 ggagccggga ctggagcaac    atg aac cgt gaa gac cgg aat gtg ctg cgt     110
                          Met Asn Arg Glu Asp Arg Asn Val Leu Arg
                            1               5                  10

 atg aaa gaa cgg gaa agg cgg aat cag gaa att cag cag ggc gaa gac      158
 Met Lys Glu Arg Glu Arg Arg Asn Gln Glu Ile Gln Gln Gly Glu Asp
                  15                  20                  25

 gcc ttc cca cct agc tct cct ctc ttt gca gag cca tac aaa gtt act      206
 Ala Phe Pro Pro Ser Ser Pro Leu Phe Ala Glu Pro Tyr Lys Val Thr
              30                  35                  40

 agc aaa gaa gat aag tta tca agt cgt att cag agt atg ctt gga aac      254
 Ser Lys Glu Asp Lys Leu Ser Ser Arg Ile Gln Ser Met Leu Gly Asn
          45                  50                  55

 tac gat gtc atg aaa gat ttc ata gga gac aga tct ata cca aag ctt      302
 Tyr Asp Val Met Lys Asp Phe Ile Gly Asp Arg Ser Ile Pro Lys Leu
      60                  65                  70

 gtt gca att ccc aag cct aca gta cca cca tca gca gat gaa aaa tct      350
 Val Ala Ile Pro Lys Pro Thr Val Pro Pro Ser Ala Asp Glu Lys Ser
  75                  80                  85                  90

 aac cca aat ttc ttt gaa cag aga cat gga ggc tct cat cag agt agc      398
 Asn Pro Asn Phe Phe Glu Gln Arg His Gly Gly Ser His Gln Ser Ser
                  95                 100                 105

 aaa tgg act cca gta gga ccc gca ccc agc act tct cag tct cag aaa      446
 Lys Trp Thr Pro Val Gly Pro Ala Pro Ser Thr Ser Gln Ser Gln Lys
             110                 115                 120

 cgg tcc tca ggc tta cag agt gga cat agt agc cag cgg acc agc gca      494
 Arg Ser Ser Gly Leu Gln Ser Gly His Ser Ser Gln Arg Thr Ser Ala
         125                 130                 135

 ggt agc agt agt ggc act aac agt agt ggt cag agg cac gac cgt gag      542
 Gly Ser Ser Ser Gly Thr Asn Ser Ser Gly Gln Arg His Asp Arg Glu
     140                 145                 150

 tca tat aac aat agt ggg agc agt agc cgg aaa aaa ggc cag cat gga      590
 Ser Tyr Asn Asn Ser Gly Ser Ser Ser Arg Lys Lys Gly Gln His Gly
 155                 160                 165                 170

 tca gaa cac tcc aaa tca cgt tct tcc agc cct gga aaa ccc cag gct      638
 Ser Glu His Ser Lys Ser Arg Ser Ser Ser Pro Gly Lys Pro Gln Ala
                 175                 180                 185

 gtt tct tca tta aac tct agt cat tcc agg tct cat ggg aat gat cac      686
 Val Ser Ser Leu Asn Ser Ser His Ser Arg Ser His Gly Asn Asp His
             190                 195                 200

 cat agc aag gaa cat caa cgc tcc aaa tca cct cgg gac cct gat gca      734
 His Ser Lys Glu His Gln Arg Ser Lys Ser Pro Arg Asp Pro Asp Ala
         205                 210                 215

 aac tgg gat tct cct tcc cgt gta cct ttt tca agt ggg cag cac tca      782
 Asn Trp Asp Ser Pro Ser Arg Val Pro Phe Ser Ser Gly Gln His Ser
     220                 225                 230

 act caa tct ttc cca ccc tca ttg atg tca aag tcc aat tca atg tta      830
 Thr Gln Ser Phe Pro Pro Ser Leu Met Ser Lys Ser Asn Ser Met Leu
 235                 240                 245                 250

 cag aaa ccc act gcc tat gtg cgg ccc atg gac gga cag gag tcc atg      878
 Gln Lys Pro Thr Ala Tyr Val Arg Pro Met Asp Gly Gln Glu Ser Met
                 255                 260                 265

 gaa cca aag ctg tcc tct gag cac tac agc agc caa tcc cat ggc aac      926
 Glu Pro Lys Leu Ser Ser Glu His Tyr Ser Ser Gln Ser His Gly Asn
             270                 275                 280

 agc atg act gag ctg aag ccc agc agc aaa gca cat ctc acc aag ctg      974
 Ser Met Thr Glu Leu Lys Pro Ser Ser Lys Ala His Leu Thr Lys Leu
         285                 290                 295

 aaa ata cct tcc caa cca ctg gat gca tca gct tct ggt gat gtg agc     1022
 Lys Ile Pro Ser Gln Pro Leu Asp Ala Ser Ala Ser Gly Asp Val Ser
     300                 305                 310

 tgt gtg gat gaa atc cta aaa gag atg acg cat tca tgg cct ccc cct     1070
 Cys Val Asp Glu Ile Leu Lys Glu Met Thr His Ser Trp Pro Pro Pro
 315                 320                 325                 330

 cta acg gct att cat aca cca tgc aaa aca gaa cct tcc aaa ttt cct     1118
 Leu Thr Ala Ile His Thr Pro Cys Lys Thr Glu Pro Ser Lys Phe Pro
                 335                 340                 345

 ttt cca act aag gag tct cag cag tcc aat ttt ggc act gga gaa caa     1166
 Phe Pro Thr Lys Glu Ser Gln Gln Ser Asn Phe Gly Thr Gly Glu Gln
             350                 355                 360

 aaa aga tat aat cct tct aaa act tca aat ggg cac cag tct aaa tct     1214
 Lys Arg Tyr Asn Pro Ser Lys Thr Ser Asn Gly His Gln Ser Lys Ser
         365                 370                 375

 atg tta aaa gat gac tta aaa cta agc agc agt gaa gac agt gat ggg     1262
 Met Leu Lys Asp Asp Leu Lys Leu Ser Ser Ser Glu Asp Ser Asp Gly
     380                 385                 390

 gaa cag gat tgt gat aag aca atg ccg agg agt aca cca gga agt aac     1310
 Glu Gln Asp Cys Asp Lys Thr Met Pro Arg Ser Thr Pro Gly Ser Asn
 395                 400                 405                 410

 tct gaa cct tca cac cat aat agt gaa gga gca gat aac tcc agg gat     1358
 Ser Glu Pro Ser His His Asn Ser Glu Gly Ala Asp Asn Ser Arg Asp
                 415                 420                 425

 gat tct agt agc cac agt gga tct gaa agc agc tct gga tct gac tca     1406
 Asp Ser Ser Ser His Ser Gly Ser Glu Ser Ser Ser Gly Ser Asp Ser
             430                 435                 440

 gag agt gaa agt agt tcc agt gac agt gag gca aat gag cca tcc cag     1454
 Glu Ser Glu Ser Ser Ser Ser Asp Ser Glu Ala Asn Glu Pro Ser Gln
         445                 450                 455

 agt gca tct ccc gag cct gaa ccc ccg cca aca aac aaa tgg caa ctt     1502
 Ser Ala Ser Pro Glu Pro Glu Pro Pro Pro Thr Asn Lys Trp Gln Leu
     460                 465                 470

 gat aat tgg ctg aat aaa gtg aac cca cat aaa gtg tca ccc gcc tct     1550
 Asp Asn Trp Leu Asn Lys Val Asn Pro His Lys Val Ser Pro Ala Ser
 475                 480                 485                 490

 tca gtg gac agt aac atc cca tca tct caa ggc tac aaa aag gaa ggc     1598
 Ser Val Asp Ser Asn Ile Pro Ser Ser Gln Gly Tyr Lys Lys Glu Gly
                 495                 500                 505

 cga gag cag ggc act ggg aat agc tac act gat aca agt gga cct aaa     1646
 Arg Glu Gln Gly Thr Gly Asn Ser Tyr Thr Asp Thr Ser Gly Pro Lys
             510                 515                 520

 gaa acg agt tcc gct act ccg gga cga gac tcc aaa acc atc caa aag     1694
 Glu Thr Ser Ser Ala Thr Pro Gly Arg Asp Ser Lys Thr Ile Gln Lys
         525                 530                 535

 gga tca gaa agt ggg cgt ggg agg cag aaa tct cct gca cag agt gac     1742
 Gly Ser Glu Ser Gly Arg Gly Arg Gln Lys Ser Pro Ala Gln Ser Asp
     540                 545                 550

 agc aca aca cag aga aga act gta ggc aaa aaa caa ccc aaa aag gct     1790
 Ser Thr Thr Gln Arg Arg Thr Val Gly Lys Lys Gln Pro Lys Lys Ala
 555                 560                 565                 570

 gag aag gca gct gct gaa gag cct cgt gga ggc ctg aag ata gaa agt     1838
 Glu Lys Ala Ala Ala Glu Glu Pro Arg Gly Gly Leu Lys Ile Glu Ser
                 575                 580                 585

 gaa acc cct gta gac ttg gct agc agc atg ccc tcc agc aga cac aaa     1886
 Glu Thr Pro Val Asp Leu Ala Ser Ser Met Pro Ser Ser Arg His Lys
             590                 595                 600

 gca gcc acc aaa ggc tca agg aaa ccc aat ata aag aag gag tct aag     1934
 Ala Ala Thr Lys Gly Ser Arg Lys Pro Asn Ile Lys Lys Glu Ser Lys
         605                 610                 615

 tct tcc cct cga cct aca gca gag aaa aag aaa tat aag tca aca agt     1982
 Ser Ser Pro Arg Pro Thr Ala Glu Lys Lys Lys Tyr Lys Ser Thr Ser
     620                 625                 630

 aaa tct tcc cag aaa tca agg gaa atc ata gaa aca gat acc tca tcc     2030
 Lys Ser Ser Gln Lys Ser Arg Glu Ile Ile Glu Thr Asp Thr Ser Ser
 635                 640                 645                 650

 tca gat tca gat gaa agt gag agc ctt cct cct tcc tca caa act cct     2078
 Ser Asp Ser Asp Glu Ser Glu Ser Leu Pro Pro Ser Ser Gln Thr Pro
                 655                 660                 665

 aag tac ccc gag agc aat agg act cct gtt aaa ccc tcc tca gtg gag     2126
 Lys Tyr Pro Glu Ser Asn Arg Thr Pro Val Lys Pro Ser Ser Val Glu
             670                 675                 680

 gaa gaa gat agc ttt ttt cgg caa cga atg ttc tct cct atg gaa gag     2174
 Glu Glu Asp Ser Phe Phe Arg Gln Arg Met Phe Ser Pro Met Glu Glu
         685                 690                 695

 aag gaa ctt ctt tca ccc ctc agt gag cct gat gac agg tac cca ctt     2222
 Lys Glu Leu Leu Ser Pro Leu Ser Glu Pro Asp Asp Arg Tyr Pro Leu
     700                 705                 710

 att gtg aag att gac ctg aat ctt ttg act aga ata cca gga aag cct     2270
 Ile Val Lys Ile Asp Leu Asn Leu Leu Thr Arg Ile Pro Gly Lys Pro
 715                 720                 725                 730

 tac aaa gaa aca gag ccg ccc aag ggg gaa aag aaa aat gtg cca gaa     2318
 Tyr Lys Glu Thr Glu Pro Pro Lys Gly Glu Lys Lys Asn Val Pro Glu
                 735                 740                 745

 aag cac acg aga gag gct cag aaa caa gcc tca gaa aaa gtt tcc aac     2366
 Lys His Thr Arg Glu Ala Gln Lys Gln Ala Ser Glu Lys Val Ser Asn
             750                 755                 760

 aaa ggc aag agg aag cat aag aat gaa gat gat aac cga gcc agt gag     2414
 Lys Gly Lys Arg Lys His Lys Asn Glu Asp Asp Asn Arg Ala Ser Glu
         765                 770                 775

 agc aag aaa ccc aaa acg gag gac aag aat tca gca ggc cat aag cca     2462
 Ser Lys Lys Pro Lys Thr Glu Asp Lys Asn Ser Ala Gly His Lys Pro
     780                 785                 790

 tcc agc aac aga gag tca tct aag cag agt gct gca aaa gaa aag gat     2510
 Ser Ser Asn Arg Glu Ser Ser Lys Gln Ser Ala Ala Lys Glu Lys Asp
 795                 800                 805                 810

 ttg ttg cct tct ccc gct ggg cct gtt cct tca aaa gat cca aaa aca     2558
 Leu Leu Pro Ser Pro Ala Gly Pro Val Pro Ser Lys Asp Pro Lys Thr
                 815                 820                 825

 gag cat ggc tct cgg aag agg act att agt cag tct tct tcc tta aag     2606
 Glu His Gly Ser Arg Lys Arg Thr Ile Ser Gln Ser Ser Ser Leu Lys
             830                 835                 840

 tca agc agt aac agc aac aag gag acg agt ggc agc agc aaa aac agt     2654
 Ser Ser Ser Asn Ser Asn Lys Glu Thr Ser Gly Ser Ser Lys Asn Ser
         845                 850                 855

 tcc tcc aca tca aag cag aag aag acc gaa ggg aag act tcc agt agc     2702
 Ser Ser Thr Ser Lys Gln Lys Lys Thr Glu Gly Lys Thr Ser Ser Ser
     860                 865                 870

 tcc aag gag gtt aag gaa aag gct cca agt agc tcc tct aac tgt cct     2750
 Ser Lys Glu Val Lys Glu Lys Ala Pro Ser Ser Ser Ser Asn Cys Pro
 875                 880                 885                 890

 cca tct gca cca act ctt gat tct tct aag cct cgg aga aca aag ctt     2798
 Pro Ser Ala Pro Thr Leu Asp Ser Ser Lys Pro Arg Arg Thr Lys Leu
                 895                 900                 905

 gtc ttt gat gac aga aat tat tca gca gac cat tat tta caa gaa gca     2846
 Val Phe Asp Asp Arg Asn Tyr Ser Ala Asp His Tyr Leu Gln Glu Ala
             910                 915                 920

 aaa aag cta aag cac aat gca gat gca ttg tct gat agg ttt gag aaa     2894
 Lys Lys Leu Lys His Asn Ala Asp Ala Leu Ser Asp Arg Phe Glu Lys
         925                 930                 935

 gct gta tac tat ctt gat gct gtg gta tct ttc att gaa tgt ggg aat     2942
 Ala Val Tyr Tyr Leu Asp Ala Val Val Ser Phe Ile Glu Cys Gly Asn
     940                 945                 950

 gca tta gag aag aat gct cag gaa tcc aaa tcc cca ttc cct atg tat     2990
 Ala Leu Glu Lys Asn Ala Gln Glu Ser Lys Ser Pro Phe Pro Met Tyr
 955                 960                 965                 970

 tca gag acg gtg gat ctc atc aaa tac act atg aag cta aag aat tac     3038
 Ser Glu Thr Val Asp Leu Ile Lys Tyr Thr Met Lys Leu Lys Asn Tyr
                 975                 980                 985

 ttg gca cca gat gct aca gct gca gat aaa cga ctc aca gta ctt tgc     3086
 Leu Ala Pro Asp Ala Thr Ala Ala Asp Lys Arg Leu Thr Val Leu Cys
             990                 995                1000

 ctg cga tgc gag tct ttg ctg tac ctg agg ctg ttc aaa ctg aag aag     3134
 Leu Arg Cys Glu Ser Leu Leu Tyr Leu Arg Leu Phe Lys Leu Lys Lys
        1005                1010                1015

 gaa aat gct ctg aag tac tca aag aca ctg aca gag cac ctg aag aat     3182
 Glu Asn Ala Leu Lys Tyr Ser Lys Thr Leu Thr Glu His Leu Lys Asn
    1020                1025                1030

 tct tat aat aat tct caa gca cca tcg cct ggc ttg gga agc aaa gct     3230
 Ser Tyr Asn Asn Ser Gln Ala Pro Ser Pro Gly Leu Gly Ser Lys Ala
1035                1040                1045                1050

 gtg ggg atg cct tcc cct gtt tct cca aag ctg tca cca ggc aat tca     3278
 Val Gly Met Pro Ser Pro Val Ser Pro Lys Leu Ser Pro Gly Asn Ser
                1055                1060                1065

 gga aat tat tca tct ggg gcc agt agt gct tct gca agt ggt tct tca     3326
 Gly Asn Tyr Ser Ser Gly Ala Ser Ser Ala Ser Ala Ser Gly Ser Ser
            1070                1075                1080

 gtg acc att cca cag aag atc cac cag atg gca gcc agc tat gtt cag     3374
 Val Thr Ile Pro Gln Lys Ile His Gln Met Ala Ala Ser Tyr Val Gln
        1085                1090                1095

 gtc aca tcc aac ttc ctc tat gcc acc gaa att tgg gac caa gct gaa     3422
 Val Thr Ser Asn Phe Leu Tyr Ala Thr Glu Ile Trp Asp Gln Ala Glu
    1100                1105                1110

 cag ctt tcc aaa gag caa aaa gaa ttc ttt gct gaa ctg gat aaa gta     3470
 Gln Leu Ser Lys Glu Gln Lys Glu Phe Phe Ala Glu Leu Asp Lys Val
1115                1120                1125                1130

 atg ggc cct ctc atc ttt aat gca agc atc atg aca gat cta gtt cgt     3518
 Met Gly Pro Leu Ile Phe Asn Ala Ser Ile Met Thr Asp Leu Val Arg
                1135                1140                1145

 tat acc cgg cag gga ctg cac tgg ctt cgc cag gat gcc aag ttg ata     3566
 Tyr Thr Arg Gln Gly Leu His Trp Leu Arg Gln Asp Ala Lys Leu Ile
            1150                1155                1160

 tct tgaa ctgaacacat tctcgttgcc tctgattttc tccacaacac tgtgtcacat     3623
 Ser 


 cacgaaggaa aactgccata acataccacc tagtcgacac taagaatgag gaatagtttt   3683

 ctcctcgttg gttcatgtgt tgttgttttt gataatccaa agcgatcatg tcagttggcc   3743

 ctttaatatt tccaatgtga aagattattt aaatgctttt aaatctgcag cacattgata   3803

 aaat                                                                3807




      <210> 10
      <211> 599
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (94)..(477)

      <400> 10
 gcggtgcgac gaaggagtag gtggtgggat ctcaccgtgg gtccgattag ccttttctct     60

 gccttgcttg cttgagcttc agcggaattc gaa atg gct ggc ggt aag gct gga     114
                                      Met Ala Gly Gly Lys Ala Gly
                                        1               5

 aag gac tcc gga aag gcc aag aca aag gcg gtt tcc cgc tcg cag aga      162
 Lys Asp Ser Gly Lys Ala Lys Thr Lys Ala Val Ser Arg Ser Gln Arg
          10                  15                  20

 gcc ggc ttg cag ttc cca gtg ggc cgt att cat cga cac cta aaa tct      210
 Ala Gly Leu Gln Phe Pro Val Gly Arg Ile His Arg His Leu Lys Ser
      25                  30                  35

 agg acg acc agt cat gga cgt gtg ggc gcg act gcc gct gtg tac agc      258
 Arg Thr Thr Ser His Gly Arg Val Gly Ala Thr Ala Ala Val Tyr Ser
  40                  45                  50                  55

 gca gcc atc ctg gag tac ctc acc gca gag gta ctt gaa ctg gca gga      306
 Ala Ala Ile Leu Glu Tyr Leu Thr Ala Glu Val Leu Glu Leu Ala Gly
                  60                  65                  70

 aat gca tca aaa gac tta aag gta aag cgt att acc cct cgt cac ttg      354
 Asn Ala Ser Lys Asp Leu Lys Val Lys Arg Ile Thr Pro Arg His Leu
              75                  80                  85

 caa ctt gct att cgt gga gat gaa gaa ttg gat tct ctc atc aag gct      402
 Gln Leu Ala Ile Arg Gly Asp Glu Glu Leu Asp Ser Leu Ile Lys Ala
          90                  95                 100

 aca att gct ggt ggt ggt gtc att cca cac atc cac aaa tct ctg att      450
 Thr Ile Ala Gly Gly Gly Val Ile Pro His Ile His Lys Ser Leu Ile
     105                 110                 115

 ggg aag aaa gga caa cag aag act gtc taaag gatgcctgga ttccttgtta      502
 Gly Lys Lys Gly Gln Gln Lys Thr Val 
 120                 125

 tctcaggact ctaaatactc taacagctgt ccagtgttgg tgattccagt ggactgtatc    562

 tctgtgaaaa acacaatttt gcctttttgt aattcta                             599




      <210> 11
      <211> 2561
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (123)..(1988)

      <400> 11
 acatagaaaa atttcatcga gagtcattct tctacactca cttgataaat ttcagtgaaa     60

 cgctgcagca gtgctgtgac ctttcgcagc tgtggttccg agagttcttc ctggagctga    120

 cc   atg ggc agg agg atc cag ttc ccc att gag atg tcg atg ccc tgg     167
      Met Gly Arg Arg Ile Gln Phe Pro Ile Glu Met Ser Met Pro Trp
        1               5                  10                  15

 atc ctg acg gac cac atc ctg gag acc aag gag gca tcg atg atg gag      215
 Ile Leu Thr Asp His Ile Leu Glu Thr Lys Glu Ala Ser Met Met Glu
                  20                  25                  30

 tac gtg ctc tac tcc ctg gac ctg tac aat gac agc gcc cac tac gcg      263
 Tyr Val Leu Tyr Ser Leu Asp Leu Tyr Asn Asp Ser Ala His Tyr Ala
              35                  40                  45

 ctc acc agg ttc aac aag cag ttc ctg tac gac gaa att gag gcc gag      311
 Leu Thr Arg Phe Asn Lys Gln Phe Leu Tyr Asp Glu Ile Glu Ala Glu
          50                  55                  60

 gtg aat cta tgt ttt gac caa ttt gtt tac aag cta gca gac cag ata      359
 Val Asn Leu Cys Phe Asp Gln Phe Val Tyr Lys Leu Ala Asp Gln Ile
      65                  70                  75

 ttt gcc tat tat aag gtt atg gca gga agt ttg ctt ctt gat aaa cgg      407
 Phe Ala Tyr Tyr Lys Val Met Ala Gly Ser Leu Leu Leu Asp Lys Arg
  80                  85                  90                  95

 tta cga tca gaa tgc aag aat cag gga gcc acg atc cac ctc ccg ccg      455
 Leu Arg Ser Glu Cys Lys Asn Gln Gly Ala Thr Ile His Leu Pro Pro
                 100                 105                 110

 tct aac cgc tac gag acg ctg ctg aag cag agg cat gtg cag ctc ctc      503
 Ser Asn Arg Tyr Glu Thr Leu Leu Lys Gln Arg His Val Gln Leu Leu
             115                 120                 125

 ggc aga tca ata gac ctc aat cgt ctg atc acc cag cgc gtc tca gca      551
 Gly Arg Ser Ile Asp Leu Asn Arg Leu Ile Thr Gln Arg Val Ser Ala
         130                 135                 140

 gcc atg tat aag tcc cta gaa ctg gcg att gga cga ttt gaa agt gaa      599
 Ala Met Tyr Lys Ser Leu Glu Leu Ala Ile Gly Arg Phe Glu Ser Glu
     145                 150                 155

 gat ttg acc tcc ata gtt gag ctg gat ggc ctg ttg gaa atc aac cgc      647
 Asp Leu Thr Ser Ile Val Glu Leu Asp Gly Leu Leu Glu Ile Asn Arg
 160                 165                 170                 175

 atg acc cac aag ctg ctg agc cgg tac ctg acg ctg gac ggc ttc gac      695
 Met Thr His Lys Leu Leu Ser Arg Tyr Leu Thr Leu Asp Gly Phe Asp
                 180                 185                 190

 gcc atg ttc cgg gag gcc aac cac aac gtg tca gcg ccc tac ggg agg      743
 Ala Met Phe Arg Glu Ala Asn His Asn Val Ser Ala Pro Tyr Gly Arg
             195                 200                 205

 atc acc ctg cac gtc ttc tgg gag ctc aac tat gac ttc ctg ccc aac      791
 Ile Thr Leu His Val Phe Trp Glu Leu Asn Tyr Asp Phe Leu Pro Asn
         210                 215                 220

 tac tgc tac aac ggc tct acc aac cgg ttt gtt cgg aca gtg tta cca      839
 Tyr Cys Tyr Asn Gly Ser Thr Asn Arg Phe Val Arg Thr Val Leu Pro
     225                 230                 235

 ttt tct cag gaa ttt caa aga gat aag cag cct aat gca cag cct cag      887
 Phe Ser Gln Glu Phe Gln Arg Asp Lys Gln Pro Asn Ala Gln Pro Gln
 240                 245                 250                 255

 tat ctg cat gga tcc aag gct ttg aac ttg gcc tac tcc agc att tac      935
 Tyr Leu His Gly Ser Lys Ala Leu Asn Leu Ala Tyr Ser Ser Ile Tyr
                 260                 265                 270

 ggc agc tac cgg aac ttc gtg gga cct cca cac ttt caa gtc atc tgc      983
 Gly Ser Tyr Arg Asn Phe Val Gly Pro Pro His Phe Gln Val Ile Cys
             275                 280                 285

 cgg ctt ctc ggc tac cag ggt atc gcc gtg gtc atg gag gag ctg ctg     1031
 Arg Leu Leu Gly Tyr Gln Gly Ile Ala Val Val Met Glu Glu Leu Leu
         290                 295                 300

 aag gtc gtc aag agc ctg ctg caa ggc aca atc ctg cag tac gtg aag     1079
 Lys Val Val Lys Ser Leu Leu Gln Gly Thr Ile Leu Gln Tyr Val Lys
     305                 310                 315

 acg ctg atg gag gtg atg ccc aag atc tgc cgc ctg ccc cgg cac gag     1127
 Thr Leu Met Glu Val Met Pro Lys Ile Cys Arg Leu Pro Arg His Glu
 320                 325                 330                 335

 tac ggc tct cct ggt atc ctg gag ttc ttc cac cac cag ctg aag gac     1175
 Tyr Gly Ser Pro Gly Ile Leu Glu Phe Phe His His Gln Leu Lys Asp
                 340                 345                 350

 atc gtg gag tac gca gag ctg aag acg gtg tgc ttc cag aac ctg cgg     1223
 Ile Val Glu Tyr Ala Glu Leu Lys Thr Val Cys Phe Gln Asn Leu Arg
             355                 360                 365

 gag gtg ggg aac gcc atc ctc ttc tgc ctg ctc atc gag cag agc ctg     1271
 Glu Val Gly Asn Ala Ile Leu Phe Cys Leu Leu Ile Glu Gln Ser Leu
         370                 375                 380

 tct tta gaa gaa gtg tgt gac ctg ctg cac gcg gct cct ttc cag aac     1319
 Ser Leu Glu Glu Val Cys Asp Leu Leu His Ala Ala Pro Phe Gln Asn
     385                 390                 395

 atc ttg ccg cga gtc cat gtg aaa gag ggg gag aga ctt gat gcc aaa     1367
 Ile Leu Pro Arg Val His Val Lys Glu Gly Glu Arg Leu Asp Ala Lys
 400                 405                 410                 415

 atg aaa aga cta gaa tca aag tac gcc ccg ctg cat ctt gtc cca ctg     1415
 Met Lys Arg Leu Glu Ser Lys Tyr Ala Pro Leu His Leu Val Pro Leu
                 420                 425                 430

 att gaa aga ctg ggg acc cct cag caa att gcc atc gca aga gag ggg     1463
 Ile Glu Arg Leu Gly Thr Pro Gln Gln Ile Ala Ile Ala Arg Glu Gly
             435                 440                 445

 gac ctg ctg aca aag gag cgc ctc tgc tgc ggc ctg tcc atg ttt gag     1511
 Asp Leu Leu Thr Lys Glu Arg Leu Cys Cys Gly Leu Ser Met Phe Glu
         450                 455                 460

 gtc atc ctg aca cgg atc cgg agc ttt ctg gat gac ccc atc tgg cgc     1559
 Val Ile Leu Thr Arg Ile Arg Ser Phe Leu Asp Asp Pro Ile Trp Arg
     465                 470                 475

 ggg cct ctg ccc agc aat ggg gtc atg cat gtg gac gag tgt gtg gag     1607
 Gly Pro Leu Pro Ser Asn Gly Val Met His Val Asp Glu Cys Val Glu
 480                 485                 490                 495

 ttt cac aga ctg tgg agt gcc atg cag ttt gtc tac tgc att ccc gtg     1655
 Phe His Arg Leu Trp Ser Ala Met Gln Phe Val Tyr Cys Ile Pro Val
                 500                 505                 510

 ggg aca cac gag ttc aca gtc gag cag tgc ttt ggt gat ggg cta cac     1703
 Gly Thr His Glu Phe Thr Val Glu Gln Cys Phe Gly Asp Gly Leu His
             515                 520                 525

 tgg gct ggc tgt atg atc atc gta ctt ctt ggg cag cag cgg cgt ttt     1751
 Trp Ala Gly Cys Met Ile Ile Val Leu Leu Gly Gln Gln Arg Arg Phe
         530                 535                 540

 gct gtg ctg gat ttc tgc tac cat cta ctt aaa gtc cag aaa cat gat     1799
 Ala Val Leu Asp Phe Cys Tyr His Leu Leu Lys Val Gln Lys His Asp
     545                 550                 555

 ggc aaa gat gag att att aaa aat gtg cct ttg aag aag atg gtg gag     1847
 Gly Lys Asp Glu Ile Ile Lys Asn Val Pro Leu Lys Lys Met Val Glu
 560                 565                 570                 575

 aga att cgc aag ttc cag att ctc aat gat gag atc atc acc atc ctg     1895
 Arg Ile Arg Lys Phe Gln Ile Leu Asn Asp Glu Ile Ile Thr Ile Leu
                 580                 585                 590

 gat aag tac ctg aag tca ggc gac ggg gag ggc acg cca gtg gag cat     1943
 Asp Lys Tyr Leu Lys Ser Gly Asp Gly Glu Gly Thr Pro Val Glu His
             595                 600                 605

 gtg cgc tgc ttc cag ccg ccc atc cac cag tcc ctc gcc agc agc tga     1991
 Val Arg Cys Phe Gln Pro Pro Ile His Gln Ser Leu Ala Ser Ser 
         610                 615                 620

 gggcacgcgc tgcactccgt aactcaacat ggcatgcctt tctctccgta aactatttag   2051

 tgagattttt agggactatt tttcagtatc tctgtacctg ttaaaggggg tgcttttcga   2111

 tctaaaaact taattttata aaattgactt atttttctag actaaaattg tatatgcttt   2171

 tggtaattag gaactcttga gaatattggc tgctgattgt tgccatcacg ttcctacaaa   2231

 attgtttttc tatgggatgt tctggcagct gtgtcataaa atgctgctgg gttcattcat   2291

 tcattccata agaaacttaa taccagcaaa tgcattaaat cccttgccag ttaccattaa   2351

 ctgtaactat ttagcttttg tttagggatc tttctgatgg tcttttatga gcaatcttag   2411

 ttctaagtca ttgttcccat cccttttttg tgtgtttcag aaaatagtga acttgattcc   2471

 cctgcttcca ctaaatccag ttgtgacaaa atctaacgtg acatcagatc gaaaggttat   2531

 agaaataaaa ctaatgagat ctaaaaaaaa                                    2561




      <210> 12
      <211> 2909
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (86)..(2299)

      <400> 12
 taagcttgcg gccgccgagt cggtctgcgc agcctcctgc gttttctcgc ttggatcttg     60

 gcactgagag gcggtggccg gcggg  atg gag aaa agt agg atg aac ctg ccc     112
                              Met Glu Lys Ser Arg Met Asn Leu Pro
                                1               5

 aag ggg ccg gac acg ctc tgc ttc gac aag gac gag ttc atg aag gaa      160
 Lys Gly Pro Asp Thr Leu Cys Phe Asp Lys Asp Glu Phe Met Lys Glu
  10                  15                  20                  25

 gat ttc gat gtc gat cat ttt gtg tct gac tgt agg aag cgg gtc cag      208
 Asp Phe Asp Val Asp His Phe Val Ser Asp Cys Arg Lys Arg Val Gln
                  30                  35                  40

 ctg gaa gaa ctg aga gat gac ctg gag ctc tac tat aaa ctt ctt aaa      256
 Leu Glu Glu Leu Arg Asp Asp Leu Glu Leu Tyr Tyr Lys Leu Leu Lys
              45                  50                  55

 aca gcc atg gtc gaa ctc atc aac aag gat tat gca gat ttt gtc aat      304
 Thr Ala Met Val Glu Leu Ile Asn Lys Asp Tyr Ala Asp Phe Val Asn
          60                  65                  70

 ctt tca aca aac ttg gtt ggc atg gac aaa gcc ctc aac cag ctt tct      352
 Leu Ser Thr Asn Leu Val Gly Met Asp Lys Ala Leu Asn Gln Leu Ser
      75                  80                  85

 gtg cct ttg gga caa tta cga gaa gag gtt ctg agc ctt aga tcg tct      400
 Val Pro Leu Gly Gln Leu Arg Glu Glu Val Leu Ser Leu Arg Ser Ser
  90                  95                 100                 105

 gtc agt gaa gga att cgg gca gtt gat gaa cga atg tct aaa caa gag      448
 Val Ser Glu Gly Ile Arg Ala Val Asp Glu Arg Met Ser Lys Gln Glu
                 110                 115                 120

 gac att agg aaa aaa aag atg tgt gta ttg agg ctt ata caa gtt att      496
 Asp Ile Arg Lys Lys Lys Met Cys Val Leu Arg Leu Ile Gln Val Ile
             125                 130                 135

 cgg tca gtt gag aaa att gaa aaa atc tta aac tct caa agt tct aaa      544
 Arg Ser Val Glu Lys Ile Glu Lys Ile Leu Asn Ser Gln Ser Ser Lys
         140                 145                 150

 gaa acc tct gca cta gaa gca agc agc ccc ctt ttg act gga caa att      592
 Glu Thr Ser Ala Leu Glu Ala Ser Ser Pro Leu Leu Thr Gly Gln Ile
     155                 160                 165

 ttg gag aga att gcc aca gaa ttt aat cag tta cag ttt cat gct gtt      640
 Leu Glu Arg Ile Ala Thr Glu Phe Asn Gln Leu Gln Phe His Ala Val
 170                 175                 180                 185

 caa agc aaa ggc atg cct ctt ttg gac aaa gta aga ccg cgt ata gct      688
 Gln Ser Lys Gly Met Pro Leu Leu Asp Lys Val Arg Pro Arg Ile Ala
                 190                 195                 200

 ggc att aca gcc atg tta cag cag tca ctg gaa ggt ctc cta tta gaa      736
 Gly Ile Thr Ala Met Leu Gln Gln Ser Leu Glu Gly Leu Leu Leu Glu
             205                 210                 215

 ggc ctt cag acg tct gac gtc gat ata ata cgg cac tgc ttg cgg act      784
 Gly Leu Gln Thr Ser Asp Val Asp Ile Ile Arg His Cys Leu Arg Thr
         220                 225                 230

 tac gcc acg att gac aag aca cgg gac gcg gag gcc tta gtt ggc caa      832
 Tyr Ala Thr Ile Asp Lys Thr Arg Asp Ala Glu Ala Leu Val Gly Gln
     235                 240                 245

 gta cta gtg aaa cca tac ata gac gag gtg att ata gag cag ttt gtt      880
 Val Leu Val Lys Pro Tyr Ile Asp Glu Val Ile Ile Glu Gln Phe Val
 250                 255                 260                 265

 gaa tct cat ccc aat ggc ctt cag gtc atg tat aat aaa ctc ctg gag      928
 Glu Ser His Pro Asn Gly Leu Gln Val Met Tyr Asn Lys Leu Leu Glu
                 270                 275                 280

 ttt gtt cct cac cat tgc cgc ctt ctt cga gaa gtc aca gga ggt gcc      976
 Phe Val Pro His His Cys Arg Leu Leu Arg Glu Val Thr Gly Gly Ala
             285                 290                 295

 atc tcc agt gaa aaa ggc aat act gtt cct gga tat gac ttt ttg gtg     1024
 Ile Ser Ser Glu Lys Gly Asn Thr Val Pro Gly Tyr Asp Phe Leu Val
         300                 305                 310

 aat tct gtt tgg cca caa ata gta caa gga tta gaa gaa aag tta ccc     1072
 Asn Ser Val Trp Pro Gln Ile Val Gln Gly Leu Glu Glu Lys Leu Pro
     315                 320                 325

 tcg ctt ttt aat cct ggg aat ccc gat gca ttt cat gag aaa tat acc     1120
 Ser Leu Phe Asn Pro Gly Asn Pro Asp Ala Phe His Glu Lys Tyr Thr
 330                 335                 340                 345

 ata agt atg gat ttt gtc aga aga ttg gaa cgg cag tgt gga tca cag     1168
 Ile Ser Met Asp Phe Val Arg Arg Leu Glu Arg Gln Cys Gly Ser Gln
                 350                 355                 360

 gct agt gta aag aga tta aga gcc cat cct gcc tat cac agc ttc aat     1216
 Ala Ser Val Lys Arg Leu Arg Ala His Pro Ala Tyr His Ser Phe Asn
             365                 370                 375

 aag aag tgg aac ttg cct gtt tat ttt caa ata aga ttt aga gaa ata     1264
 Lys Lys Trp Asn Leu Pro Val Tyr Phe Gln Ile Arg Phe Arg Glu Ile
         380                 385                 390

 gcg gga tcc tta gaa gca gca ctt aca gat gtc ctg gaa gat gcc cca     1312
 Ala Gly Ser Leu Glu Ala Ala Leu Thr Asp Val Leu Glu Asp Ala Pro
     395                 400                 405

 gct gaa agt ccg tat tgc ctt ttg gct tct cat aga act tgg agc agc     1360
 Ala Glu Ser Pro Tyr Cys Leu Leu Ala Ser His Arg Thr Trp Ser Ser
 410                 415                 420                 425

 ctt agg agg tgt tgg tca gat gag atg ttc ttg cca tta ctg gtg cat     1408
 Leu Arg Arg Cys Trp Ser Asp Glu Met Phe Leu Pro Leu Leu Val His
                 430                 435                 440

 cgc ctg tgg aga ctc act ctg cag att ttg gca cga tac tct gtg ttt     1456
 Arg Leu Trp Arg Leu Thr Leu Gln Ile Leu Ala Arg Tyr Ser Val Phe
             445                 450                 455

 gtc aat gag ctt tca ctc agg ccc att tct aat gaa agt ccc aag gag     1504
 Val Asn Glu Leu Ser Leu Arg Pro Ile Ser Asn Glu Ser Pro Lys Glu
         460                 465                 470

 atc aag aaa cct ttg gta act ggt agc aaa gaa cct tcc atc acc caa     1552
 Ile Lys Lys Pro Leu Val Thr Gly Ser Lys Glu Pro Ser Ile Thr Gln
     475                 480                 485

 gga aac act gaa gac caa gga agt ggt cct tcg gaa aca aag cct gtg     1600
 Gly Asn Thr Glu Asp Gln Gly Ser Gly Pro Ser Glu Thr Lys Pro Val
 490                 495                 500                 505

 gtt tcc att tcc cgc act cag ctc gtg tat gtg gtt gca gac ctg gac     1648
 Val Ser Ile Ser Arg Thr Gln Leu Val Tyr Val Val Ala Asp Leu Asp
                 510                 515                 520

 aag ctt cag gag cag ctt cca gaa ctc ttg gaa ata atc aag cca aaa     1696
 Lys Leu Gln Glu Gln Leu Pro Glu Leu Leu Glu Ile Ile Lys Pro Lys
             525                 530                 535

 ctt gaa atg att ggc ttt aag aat ttt tct tct atc tca gca gcc ctg     1744
 Leu Glu Met Ile Gly Phe Lys Asn Phe Ser Ser Ile Ser Ala Ala Leu
         540                 545                 550

 gag gac tcc cag agc tct ttt tca gcc tgt gtg ccc tcc ttg agt agc     1792
 Glu Asp Ser Gln Ser Ser Phe Ser Ala Cys Val Pro Ser Leu Ser Ser
     555                 560                 565

 aag atc atc cag gat tta agt gac tct tgc ttc ggt ttc cta aaa agc     1840
 Lys Ile Ile Gln Asp Leu Ser Asp Ser Cys Phe Gly Phe Leu Lys Ser
 570                 575                 580                 585

 gcc ctg gag gtt ccc agg ctt tac cga aga acc aat aag gag gtc cca     1888
 Ala Leu Glu Val Pro Arg Leu Tyr Arg Arg Thr Asn Lys Glu Val Pro
                 590                 595                 600

 acc aca gct tcc tcc tat gtg gac agt gct ctg aag ccc tta ttc cag     1936
 Thr Thr Ala Ser Ser Tyr Val Asp Ser Ala Leu Lys Pro Leu Phe Gln
             605                 610                 615

 ctt cag agc gga cac aag gat aag ctc aaa caa gca ata att cag cag     1984
 Leu Gln Ser Gly His Lys Asp Lys Leu Lys Gln Ala Ile Ile Gln Gln
         620                 625                 630

 tgg cta gaa ggc act ctc agt gaa agc act cat aag tac tat gaa acc     2032
 Trp Leu Glu Gly Thr Leu Ser Glu Ser Thr His Lys Tyr Tyr Glu Thr
     635                 640                 645

 gtg tca gat gta tta aac tct gtg aag aag atg gaa gag agc ctg aaa     2080
 Val Ser Asp Val Leu Asn Ser Val Lys Lys Met Glu Glu Ser Leu Lys
 650                 655                 660                 665

 agg ctg aaa caa gcc aga aaa acc act ccc gcc aac ccc gtc ggt ccc     2128
 Arg Leu Lys Gln Ala Arg Lys Thr Thr Pro Ala Asn Pro Val Gly Pro
                 670                 675                 680

 agt ggt ggc atg agc gac gac gac aaa atc agg ctg cag ttg gcc cta     2176
 Ser Gly Gly Met Ser Asp Asp Asp Lys Ile Arg Leu Gln Leu Ala Leu
             685                 690                 695

 gat gtt gag tac ttg gga gag cag ata caa aag ttg gga cta caa gca     2224
 Asp Val Glu Tyr Leu Gly Glu Gln Ile Gln Lys Leu Gly Leu Gln Ala
         700                 705                 710

 agt gac ata aaa agc ttc tca gct ctc gca gag ctt gtt gct gct gcc     2272
 Ser Asp Ile Lys Ser Phe Ser Ala Leu Ala Glu Leu Val Ala Ala Ala
     715                 720                 725

 aag gac cag gca aca gca gag cag cct taagc atcttggaag atcccgaggt     2324
 Lys Asp Gln Ala Thr Ala Glu Gln Pro 
 730                 735

 tagattctta agcaagagaa gagttggact tccaggctga aggggagaaa gtgactctgt   2384

 tctcttagca accgtctgta gcaaagaagt gcttccagca tcactccagc aacacgccca   2444

 tgcgtcttct ctcagcgtat ttgggtcttc tttgcccaaa agaacacaaa agcctttttc   2504

 cattgtatgg aagatagttt ttaagacatt tgaaactttc tactatagtt tacagaacaa   2564

 attattttat ttttattgta aatcttagtg tggaagagct gatttctaaa atatgattaa   2624

 agtaaatata tacctatgaa tatcaagagt cgtctccctg agcctgtagt tggaagtgac   2684

 gactgtaatg gaatgatgtc ttgtatagaa attcgaaatg cccttctctg aaataaagag   2744

 aactcctggg ctttctaaag aggctgcggg aagccatcct ccactcccac tgtgtgtgag   2804

 agcagtgctt ctgatcctgc tgtcaccccg acctctggca ggagccggcg ccagtaggaa   2864

 agacctcctt cctaaataaa agaagtgtct cccaaaaaaa aaaaa                   2909




      <210> 13
      <211> 655
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (134)..(430)

      <400> 13
 agccgagctg ggcgagaagt aggggagggc ggtgctccgc cgcggtggcg gttgctatcg     60

 cttcgcagaa cctactcagg cagccagctg agaagagttg agggaaagtg ctgctgctgg    120

 gtctgcagac gcg   atg gat aac gtg cag ccg aaa ata aaa cat cgc ccc     169
                  Met Asp Asn Val Gln Pro Lys Ile Lys His Arg Pro
                    1               5                  10

 ttc tgc ttc agt gtg aaa ggc cac gtg aag atg ctg cgg ctg gat att      217
 Phe Cys Phe Ser Val Lys Gly His Val Lys Met Leu Arg Leu Asp Ile
          15                  20                  25

 atc aac tca ctg gta aca aca gta ttc atg ctc atc gta tct gtg ttg      265
 Ile Asn Ser Leu Val Thr Thr Val Phe Met Leu Ile Val Ser Val Leu
      30                  35                  40

 gca ctg ata cca gaa acc aca aca ttg aca gtt ggt gga ggg gtg ttt      313
 Ala Leu Ile Pro Glu Thr Thr Thr Leu Thr Val Gly Gly Gly Val Phe
  45                  50                  55                  60

 gca ctt gtg aca gca gta tgc tgt ctt gcc gac ggg gcc ctt att tac      361
 Ala Leu Val Thr Ala Val Cys Cys Leu Ala Asp Gly Ala Leu Ile Tyr
                  65                  70                  75

 cgg aag ctt ctg ttc aat ccc agc ggt cct tac cag aaa aag cct gtg      409
 Arg Lys Leu Leu Phe Asn Pro Ser Gly Pro Tyr Gln Lys Lys Pro Val
              80                  85                  90

 cat gaa aaa aaa gaa gtt ttg ta attttatatt actttttagt ttgatactaa      462
 His Glu Lys Lys Glu Val Leu 
          95

 gtattaaaca tatttctgta ttcttccaaa aaaaaaaaaa aaaaaggggg gcccgtttta    522

 gagatccctt gggggggcca aagttaacgc gggcgggcga agaaaaagct ttttccttat    582

 agggggggga attataacct acctgggaat ttttggaaag aacctttttt tttggggggg    642

 aaaaaattgg gcc                                                       655




      <210> 14
      <211> 908
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (386)..(841)

      <400> 14
 cgacaggaag actcctcaga agagctggag tgctgccgtc attaacgcca ggccagaaca     60

 cgcgggctaa cagggcgctg gcctgcgtgc ccacctctag gtccgctaat atgtgcccag    120

 ctctaggtcc gctaatgtgc tacgcgataa ctgaaagaca gcacaagcca gagcggacgg    180

 ccgcgggatc ccgttggggc gcatgcgcga gagcgaacgc ggcgccgtgc gcatgcgcgc    240

 aagagagcgg gaagccgagc tgggcgagaa gtaggggagg gcggtgctcc gccgcggtgg    300

 cggttgctat cgcttcgcag aacctactca ggcagccagc tgagaagagt tgagggaaag    360

 tgctgctgct gggtctgcag acgcg  atg gat aac gtg cag ccg aaa ata aaa     412
                              Met Asp Asn Val Gln Pro Lys Ile Lys
                                1               5

 cat cgc ccc ttc tgc ttc agt gtg aaa ggc cac gtg aag atg ctg cgg      460
 His Arg Pro Phe Cys Phe Ser Val Lys Gly His Val Lys Met Leu Arg
  10                  15                  20                  25

 ctg gca cta act gtg aca tct atg acc ttt ttt atc atc gca caa gcc      508
 Leu Ala Leu Thr Val Thr Ser Met Thr Phe Phe Ile Ile Ala Gln Ala
                  30                  35                  40

 cct gaa cca tat att gtt atc act gga ttt gaa gtc acc gtt atc tta      556
 Pro Glu Pro Tyr Ile Val Ile Thr Gly Phe Glu Val Thr Val Ile Leu
              45                  50                  55

 ttt ttc ata ctt tta tat gta ctc aga ctt gat cga tta atg aag tgg      604
 Phe Phe Ile Leu Leu Tyr Val Leu Arg Leu Asp Arg Leu Met Lys Trp
          60                  65                  70

 tta ttt tgg cct ttg ctt gat att atc aac tca ctg gta aca aca gta      652
 Leu Phe Trp Pro Leu Leu Asp Ile Ile Asn Ser Leu Val Thr Thr Val
      75                  80                  85

 ttc atg ctc atc gta tct gtg ttg gca ctg ata cca gaa acc aca aca      700
 Phe Met Leu Ile Val Ser Val Leu Ala Leu Ile Pro Glu Thr Thr Thr
  90                  95                 100                 105

 ttg aca gtt ggt gga ggg gtg ttt gca ctt gtg aca gca gta tgc tgt      748
 Leu Thr Val Gly Gly Gly Val Phe Ala Leu Val Thr Ala Val Cys Cys
                 110                 115                 120

 ctt gcc gac ggg gcc ctt att tac cgg aag ctt ctg ttc aat ccc agc      796
 Leu Ala Asp Gly Ala Leu Ile Tyr Arg Lys Leu Leu Phe Asn Pro Ser
             125                 130                 135

 ggt cct tac cag aaa aag cct gtg cat gaa aaa aaa gaa gtt ttg taa      844
 Gly Pro Tyr Gln Lys Lys Pro Val His Glu Lys Lys Glu Val Leu 
         140                 145                 150

 ttttatatta ctttttagtt tgatactaag tattaaacat atttctgtat tcttccacat    904

 aaaa                                                                 908




      <210> 15
      <211> 7619
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (175)..(714)

      <400> 15
 agcggccgcc ggccccggga ctgaccggcc tcgccgcacc tcccgcaccg actagcgctc     60

 ccgggcgctc ctgcgcccga ctcgccctcg cccccactcc ccggcggggt ggcggcggcc    120

 gggcccccac ggcggcggcc ggagcagcag cagcagcagc aggagcccgc ctct  atg     177
                                                              Met
                                                                1

 atg aag ttc aag ccc aac cag acg cgg acc tac gac cgc gag ggc ttc      225
 Met Lys Phe Lys Pro Asn Gln Thr Arg Thr Tyr Asp Arg Glu Gly Phe
               5                  10                  15

 aag aag cgg gcg gcg tgc ctg tgc ttc cgg agc gag cag gag gac gag      273
 Lys Lys Arg Ala Ala Cys Leu Cys Phe Arg Ser Glu Gln Glu Asp Glu
          20                  25                  30

 gtg ctg ctg gtg agt agc agc cgg tac cca gac cag tgg att gtc cca      321
 Val Leu Leu Val Ser Ser Ser Arg Tyr Pro Asp Gln Trp Ile Val Pro
      35                  40                  45

 gga gga gga atg gaa ccc gag gag gaa cct ggc ggt gct gcc gtg agg      369
 Gly Gly Gly Met Glu Pro Glu Glu Glu Pro Gly Gly Ala Ala Val Arg
  50                  55                  60                  65

 gaa gtt tat gag gag gct gga gtc aaa gga aaa cta ggc aga ctt ctg      417
 Glu Val Tyr Glu Glu Ala Gly Val Lys Gly Lys Leu Gly Arg Leu Leu
                  70                  75                  80

 ggc ata ttt gag aac caa gac cga aag cac aga aca tat gtt tat gtt      465
 Gly Ile Phe Glu Asn Gln Asp Arg Lys His Arg Thr Tyr Val Tyr Val
              85                  90                  95

 cta aca gtc act gaa ata tta gaa gat tgg gaa gat tct gtt aat att      513
 Leu Thr Val Thr Glu Ile Leu Glu Asp Trp Glu Asp Ser Val Asn Ile
         100                 105                 110

 gga agg aag aga gag tgg ttc aaa gta gaa gat gct atc aaa gtt ctc      561
 Gly Arg Lys Arg Glu Trp Phe Lys Val Glu Asp Ala Ile Lys Val Leu
     115                 120                 125

 cag tgt cat aaa cct gta cat gca gag tat ctg gaa aag cta aag ctg      609
 Gln Cys His Lys Pro Val His Ala Glu Tyr Leu Glu Lys Leu Lys Leu
 130                 135                 140                 145

 ggt tgt tcc cca gcc aat gga aat tct aca gtc cct tcc ctt ccg gat      657
 Gly Cys Ser Pro Ala Asn Gly Asn Ser Thr Val Pro Ser Leu Pro Asp
                 150                 155                 160

 aat aat gcc ttg ttt gta acc gct gca cag acc tct ggg ttg cca tct      705
 Asn Asn Ala Leu Phe Val Thr Ala Ala Gln Thr Ser Gly Leu Pro Ser
             165                 170                 175

 agt gta aga tagagag aactgggtag gcctctccca ccatgtgcag tctcatgggg      761
 Ser Val Arg 
         180

 agaggcttct ttcgtttcct cgtcaaacat ctgattgacg cttgcaaact gtctgaattt    821

 gccatgcaag gttttcaaac aatttgcatg tttttcagat gctttcaaat ctttttttaa    881

 aaaaatagtg taaaatattt taataagcca aagccatgtg gaatttttgt ttagatgcct    941

 taactgtgcc acaccccaca accccctata ttattttggt tgtctatttc tcacagcata   1001

 ttttcagttt tttgtccatt tgacatcagt ctgtggttta ttttgtcatc agattacttg   1061

 tgggtatacc taccccaaaa ttgttttctc attcacagca ttagcatatt cagcaaatcc   1121

 atctgtggtg ggaattaaaa atattattgg tattaaagaa atccattcac cccaaaactt   1181

 gttttacagg attacaattt taattcaaaa tttccagatt tgggctattt ctgtatgatc   1241

 caataactta ttttgtcaca gggcttaatt tgccattttt ggggatttgt cgactcattt   1301

 tgtctgaatt ttcacaactg gtattatgtc actagctacc tgatacggct atttccctta   1361

 taactcaata gtaccttaac acaaagtata actctgtaga gttggtgaat attttaggga   1421

 aatattagca aaatgcatgt agtaaagaca tcttatgaaa actgtattca tggaatttga   1481

 tttagcatgc tcagttgcca gttcccatta tcgatactct ttctttgcag aataccttag   1541

 aaccgttatt tccctcagtg tagattgctc ttaaaatgta ttcagttatt tagtggcccc   1601

 cacaggagtg gagtcttgaa atctaattct aaatgccagt cagtgatgat cgcatcacag   1661

 ttgagtgaaa tggccttcct gttcagctgt tagagactga agattgttag ggcaccttag   1721

 aatgtctcat cttttctagg ttgtcaacag gtactatttg tcacataact aactttcgag   1781

 gcactggaac atacctgaac taagaattaa atcttttact ttatactcac ttaaaatcaa   1841

 gaatcccatc taaaacacat aggtacctta tctgaaactc ttgcacttcc ccaaccaggg   1901

 cagaaatgag gtgggagaag tttgactaaa atgagggatg ggggaaagta aaagatgttt   1961

 tttttttttt gagactcgct ttgtcaccca ggctggagtg caatggcaca atctcaactc   2021

 accgcaacct ccgcctcccg ggttcaggcg attctcctgc ctcagcctcc cgagtagttg   2081

 ggattacagg cgcctgcctc catgcctggc taattttgta tttttagtag agacagggtt   2141

 tcttcatgtt ggtcaggctg gtctcaaact cctaacctcg tgatccgcct gcctcgacct   2201

 cccaaagtgc tgggattaca ggcatgagcc accatgccca gccaaagatc atttttttat   2261

 atagacttca gccctttgta aatattgtaa ctggggagta tagagtagaa aaaaagtata   2321

 gttaaaacat ttgttctaca aattaacctt taaaaatata attactgcta aaaatagagt   2381

 gctgttacac ttaaggaaaa ttagtgccat tttggaaatg agatcttgtg ccataaatac   2441

 agctgaactg aatataaatg ttcacaaatt aatgctgtca aaggaatgag taaagcagaa   2501

 aaacttttaa ccagcaacat ttcaagtacg tagtgtgatc aaacatgatc atccagaatt   2561

 tttatatttt tttctttgta cagaggttac atattctggg tgttctttta taaaggaaac   2621

 attttaaatc ccacaaattg acactttcta tcttcaatgg actaagattt ttttggtcag   2681

 taatctctga aatttcctta aattatatac ttaacatagc agagaaactg gattgttttt   2741

 gtatataaga ctgcttccac ctgaaatgct gtcataagta ctgggggggt gggggagtgc   2801

 ccatcttgta catgatattc ttagaggtaa taaggtaatg atgcatgaat ttattttata   2861

 aactcttgga ctatgtattt gacatgtaaa atatgtacag tattaacgtc aaccatctct   2921

 ttaaagttag cctataaata ttgttgtata attttctttg gtcagaaaca cttggactga   2981

 atagtgacac tcggtaagga ttttcagtgc catttagcaa aacgtcttta gtctatgcaa   3041

 ctagcaaaaa tctgcataat gcaacaacac agttttcaca cttcaaattt tacatgaggg   3101

 gttcttcacg attctcctgg aacccagtct agcaaaatga gaggaaaggc cctagggaga   3161

 tttatttctg ttaaatagtt aactctgctg agtatgacaa atagtgtcta ctatctcaac   3221

 cctccaaaat ttgcagagtg ttgggactgt catttgtgat tttttttttt ttttttggtg   3281

 gggtagttga ataaaattgg gcagctaaat ttttcagttc catgtgcctc ccaaataaaa   3341

 aacagaaaat aagtagtttt tgtgaattga cttgcagaca aagtagaaac tgtgctgcat   3401

 gatgttattt tgtaacagat gacattttct gaccaggcac atgccatcca attttctgtc   3461

 aatcacactg ttgtataaag cagcagaact gaaggggaaa aatgattgtt gtatacactg   3521

 aattgctttg catggtctca tttgagataa ttgatgtaag aatcctgact tttttatatt   3581

 tggaaacatc aaataaaaat ggaaaaaatg atcatggctt taaaaaaaaa aacaaaaaca   3641

 cacacacatg aactcagatt tgcaaaccag gtttctgaaa ctttgggtaa ggtgtatgct   3701

 tttaactttg aaatgtataa acacccagcg gaaacgtata cctttcagtg catagtgcat   3761

 tgtgtgctta ccctgggttg tttaaacttg tgttcaaata ttccccctcc aagtgaaagc   3821

 ctgtcgggaa ttccacagta acacctttac tgttctccca ttgatgatca tatacgttac   3881

 ctcttcctag cggtacattt gtatgatcct tactactgga attaccgggt taaaaggaaa   3941

 tgcttaccac taagatgtca gtattctcct catggatatt ttcagtctca atgttgccag   4001

 tctaatagta tagtatgtgg ttgctttact gctgttctcc ccacccccgt ggagttgtgt   4061

 cattatttta atgaatgtga gctcttgact tactctagaa ttctaataca gatactttct   4121

 gcactagtat cacttttatt attgcagttc catttaaaag cataactggc taagtcaccg   4181

 ccccacccgc cgccattaca tttcctaaaa catactgctg ccaaagacca actgtagaat   4241

 ccttaagtcc tgttcaagtg tcacttcatt ttttattagg ggtttcttag ttggagggca   4301

 tgagaaactt ggccctttcc aatgttgtct tcacattgga gtataagaat tctctatagg   4361

 actcttttaa tttttttttt ttttttggta gagatggggt cttgctgtgt tgcccaggct   4421

 ggtctcaaac tcctaggctt aagcagtcct ccagcctcag ccttctcaaa gtgctaggat   4481

 gattggcatg agccacctcg tctggcctgc aggtcttttt aagcatttgc tgttcaataa   4541

 taagcatctt ctttatgcct agtatttgtg ataagagcac aaaacaattt tctaatctca   4601

 aagagcttat attctagtgg ggtagagata agtgatttat cttggtgtag ttttggcttt   4661

 tttgtttgtt tttttgagac agcatctcac actgtcgccc aggctggagt gcagtggtgc   4721

 aatctcagct tactgtaacc tccgcctgcc aggttcaagc gattctcctg cctcatcctc   4781

 ccgaggagct gggatcacag gcgcctgcca ccacgcccgg ctaatttttt tgtattttta   4841

 gtagagacgg ggtttcacca tattggccag gctggtctca aactcctgac ctcgtgatcc   4901

 gcctgcctcg gcctccctaa gtgctgggat tatgggcgtg aaccaccgca cctggcctat   4961

 cttggtgttt ttacatcctt cagtattttt caaggtttta cagctttttt atctatagac   5021

 ttataccatc ttcaaaagca atacaatttt atttgtagac gtgatttccc ccaccaaatg   5081

 cacattttat ggagctctag gacaaaagtc aggatgaaaa gtaatctatc gctggtgcta   5141

 ctttaatacc ttcctgactg gtgccactgg ctaaattcta gcagtacgat gagagggcca   5201

 ttaaggccta tcttagcaag caagacatta tagcaaagac ctaaacactc aaaggttcaa   5261

 cgtcttctag ccagggaact attctctaat tcttccacct tgatatgatt tcagcaaatt   5321

 ctgataaccc ggtattactc ttaatgcatt tttgtaacat ttgacaaaca tctcccaata   5381

 tgtagactcc cactctcctg atgctaatca gtatcagaca atggaagtaa attttcctgc   5441

 ttttctcaac ttttcctcaa attcatgtta gtgaagtact ttcatttggc catcattatt   5501

 tatcaacctt aagaaacatg cctattgacg aagtaaatat actaggaatt caacgtatct   5561

 acgggaatgt ggacaaagac atataccaag acaaggcact agagtgaaaa gccattaaaa   5621

 taaaatgctc agcagcaaag gatttgtaat ggttaacttg caatatatcc atatggtgta   5681

 atattacagt cattagaaat gacatttgcg taaggatctg agtggaaact gatacagcct   5741

 gtcggagagc tactgagtag tattttatca cagctgcata catacccttt cacccaacag   5801

 ttccactcct gggagtctag tcaacaaatg gacaagttgc acaaccaagc tatggtcaaa   5861

 tatgtgtgtt gtaggattta tgaaactggt accaatttaa tattcaaatg tgattaagtc   5921

 atggcaatct atttactgga tactttgtgg ttaccaaaga gctatgtgct gccacaggga   5981

 gtcctttcaa tagtgattga aaaaggcaga acactactag acagaactac ctgttttatg   6041

 catgtattgg catacactga aaaagcttag tcacttaaaa tgaggttgta cagattgtag   6101

 attttgtttt taaacgcctg tatggtttaa aaaatgtttt gggaaataga catgagcagg   6161

 gcagagaact acaacctaca ggccaaaccc caccccactg cctgtttgta cggccaacaa   6221

 gtttaaaatt tttttaatgt tttaggtttt ttttttttta aaaaaaatac tatgcccatt   6281

 tgtttacaaa tcgtctgtgg gtgctttctc actacaatgg cagaattcag tagttgagac   6341

 agacctatgg tccacaaagg ccgaaatatt tactgtttta ggagaaaaaa acaacatgaa   6401

 ttgtaataac ttggacttac ttggttgctc agtcctgatg tgtcctgtta aaacctaaga   6461

 gaaacagcac caagttcaat ctagtgcaat cagcctatca catctaagct gcttttgcca   6521

 gatctgatat ctactcccga ccttaagcca ggagactttg taaacttact aggttataat   6581

 aaaacttaag aactatcgat atttactaat ctacatcatg gaactatttc aaaagcagtc   6641

 atatggtaag atggatcagg agtctttaaa aataaaactg agaaagaaaa atcatgtgat   6701

 caattcagta gtagagacag aggttggtat caagtctatg ttcatacact taccagtgcc   6761

 acccagcagg gccatacaag acacatgaaa tgagatcagc tcaagggtga caagatgaaa   6821

 ctgggagagg gccggggaga cccgaactct taatattgga ttccacacaa gaggaaaaat   6881

 tttagtccag ctcccagcat ggcagctaat ggcaagttac tcagtaccat aaagccaact   6941

 cttggaatat acctgacttc cacgataaaa tggagatgag tgcaggggtg agtgtatagt   7001

 taagaaaaca aacaatatat tactagtcca ggtggtagat gacagatttt tattatttac   7061

 acttctctca aattattaca ttcagcatgt tttgcttttt atgttattta aagtataaac   7121

 cctcatataa ttccctaaga tgggtggcat gccaagtagc taaatgaaat atcatcccag   7181

 cccaaaagta cttattcgaa tgaaatatta catttttctt aaataaagca ataaattagg   7241

 taccctatta tcatggtatt ttcttttttg gccagctttt ctagataagg ttgtattgct   7301

 actgcaacta acaaaaaaga tgtggcaggg ctgggcacgg tggctcacgc ctgtaatccc   7361

 agcactttgg gaggccgagg cgggcagatc acgaggtcag gagatggaga ccatcctggc   7421

 ccaacatggt gaaaccccgt ctctactaaa aatacaaaaa attggccagg tgtggtggca   7481

 ggtgtctgta gtcccagctc ctcgggaggc tgaggcagga gaatcgcttg aacgcgggag   7541

 gcagaacctg cagtgagcca agatcatgcc acagcactcc agcctaaact acagagctag   7601

 aaagtggcta gagcagcc                                                 7619




      <210> 16
      <211> 1155
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (142)..(651)

      <400> 16
 ggccgtgtgc agacccgcgt gtggcgcagg caaggaccct caaaataaac agcctctacc     60

 ttgcgagccg tcttccccag gcctgcgtcc gagtctccgc cgctgcgggc ccgctccgac    120

 gcggaagatc tgactgcagc c  atg agc agc aat gag tgc ttc aag tgt gga     171
                          Met Ser Ser Asn Glu Cys Phe Lys Cys Gly
                            1               5                  10

 cga tct ggc cac tgg gcc cgg gaa tgt cct act ggt gga ggc cgt ggt      219
 Arg Ser Gly His Trp Ala Arg Glu Cys Pro Thr Gly Gly Gly Arg Gly
                  15                  20                  25

 cgt gga atg aga agc cgt ggc aga ggt ttc cag ttt gtt tcc tcg tct      267
 Arg Gly Met Arg Ser Arg Gly Arg Gly Phe Gln Phe Val Ser Ser Ser
              30                  35                  40

 ctt cca gat att tgt tat cgc tgt ggt gag tct ggt cat ctt gcc aag      315
 Leu Pro Asp Ile Cys Tyr Arg Cys Gly Glu Ser Gly His Leu Ala Lys
          45                  50                  55

 gat tgt gat ctt cag gag gat gcc tgc tat aac tgc ggt aga ggt ggc      363
 Asp Cys Asp Leu Gln Glu Asp Ala Cys Tyr Asn Cys Gly Arg Gly Gly
      60                  65                  70

 cac att gcc aag gac tgc aag gag ccc aag aga gag cga gag caa tgc      411
 His Ile Ala Lys Asp Cys Lys Glu Pro Lys Arg Glu Arg Glu Gln Cys
  75                  80                  85                  90

 tgc tac aac tgt ggc aaa cca ggc cat ctg gct cgt gac tgc gac cat      459
 Cys Tyr Asn Cys Gly Lys Pro Gly His Leu Ala Arg Asp Cys Asp His
                  95                 100                 105

 gca gat gag cag aaa tgc tat tct tgt gga gaa ttc gga cac att caa      507
 Ala Asp Glu Gln Lys Cys Tyr Ser Cys Gly Glu Phe Gly His Ile Gln
             110                 115                 120

 aaa gac tgc acc aaa gtg aag tgc tat agg tgt ggt gaa act ggt cat      555
 Lys Asp Cys Thr Lys Val Lys Cys Tyr Arg Cys Gly Glu Thr Gly His
         125                 130                 135

 gta gcc atc aac tgc agc aag aca agt gaa gtc aac tgt tac cgc tgt      603
 Val Ala Ile Asn Cys Ser Lys Thr Ser Glu Val Asn Cys Tyr Arg Cys
     140                 145                 150

 ggc gag tca ggg cac ctt gca cgg gaa tgc aca att gag gct aca gcc      651
 Gly Glu Ser Gly His Leu Ala Arg Glu Cys Thr Ile Glu Ala Thr Ala 
 155                 160                 165                 170

 taattatttt cctttgtcgc ccctcctttt tctgattgat ggttgtatta ttttctctga    711

 atcctcttca ctggccaaag gttggcagat agaggcaact cccaggccag tgagctttac    771

 ttgccgtgta aaaggaggaa aggggtggaa aaaaaccgcc tttctgcatt taactacaaa    831

 aaaagtttat gtttagtttg gtagaggtgt tatgtataat gctttgttaa agaaccccct    891

 ttccgtgcca ctggtgaata gggattgatg aatgggaaaa gttgagtcag accagtaagc    951

 ccgtcctggg ttccttgaac atgttcccat gtaggaggta aaaccaattt tggaagtgtt   1011

 tatgaacttc cataaataac tttaatttta gtataatgat ggtcttggat tgtttgccct   1071

 cagtagctat taaataacat caagtaacat ttgtatcagg ccctacatag aacatccagt   1131

 tgagtgagag ttcccaaaaa aaaa                                          1155




      <210> 17
      <211> 1975
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (132)..(662)

      <400> 17
 agacccgcgt gtggcgcagg caaggaccct caaaataaac agcctctacc ttgcgagccg     60

 tcttccccag gcctgcgtcc gagtctccgc cgctgcgggc ccgctccgac gcggaagatc    120

 tgactgcagc c atg agc agc aat gag tgc ttc aag tgt gga cga tct ggc     170
              Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly
                1               5                  10

 cac tgg gcc cgg gaa tgt cct act ggt gga ggc cgt ggt cgt gga atg      218
 His Trp Ala Arg Glu Cys Pro Thr Gly Gly Gly Arg Gly Arg Gly Met
      15                  20                  25

 aga agc cgt ggc aga ggt ggt ttt acc tcg gat aga ggt ttc cag ttt      266
 Arg Ser Arg Gly Arg Gly Gly Phe Thr Ser Asp Arg Gly Phe Gln Phe
  30                  35                  40                  45

 gtt tcc tcg tct ctt cca gat att tgt tat cgc tgt ggt gag tct ggt      314
 Val Ser Ser Ser Leu Pro Asp Ile Cys Tyr Arg Cys Gly Glu Ser Gly
                  50                  55                  60

 cat ctt gcc aag gat tgt gat ctt cag gag gat gcc tgc tat aac tgc      362
 His Leu Ala Lys Asp Cys Asp Leu Gln Glu Asp Ala Cys Tyr Asn Cys
              65                  70                  75

 ggt aga ggt ggc cac att gcc aag gac tgc aag gag ccc aag aga gag      410
 Gly Arg Gly Gly His Ile Ala Lys Asp Cys Lys Glu Pro Lys Arg Glu
          80                  85                  90

 cga gag caa tgc tgc tac aac tgt ggc aaa cca ggc cat ctg gct cgt      458
 Arg Glu Gln Cys Cys Tyr Asn Cys Gly Lys Pro Gly His Leu Ala Arg
      95                 100                 105

 gac tgc gac cat gca gat gag cag aaa tgc tat tct tgt gga gaa atc      506
 Asp Cys Asp His Ala Asp Glu Gln Lys Cys Tyr Ser Cys Gly Glu Ile
 110                 115                 120                 125

 gga cac att caa aaa gac tgc acc aaa gtg aag tgc tat agg tgt ggt      554
 Gly His Ile Gln Lys Asp Cys Thr Lys Val Lys Cys Tyr Arg Cys Gly
                 130                 135                 140

 gaa act ggt cat gta gcc atc aac tgc agc aag aca agt gaa gtc aac      602
 Glu Thr Gly His Val Ala Ile Asn Cys Ser Lys Thr Ser Glu Val Asn
             145                 150                 155

 tgt tac cgc tgt ggc gag tca ggg cac ctt gca cgg gaa tgc aca att      650
 Cys Tyr Arg Cys Gly Glu Ser Gly His Leu Ala Arg Glu Cys Thr Ile
         160                 165                 170

 gag gct aca gcc taa ttattttcct ttgtcgcccc tcctttttct gattgatggt      705
 Glu Ala Thr Ala 
     175

 tgtattattt tctctgaatc ctcttcactg gccaaaggtt ggcagataga ggcaactccc    765

 aggccagtga gctttacttg ccgtgtaaaa ggaggaaagg ggtggaaaaa aaccgacttt    825

 ctgcatttaa ctacaaaaaa agtttatgtt tagtttggta gaggtgttat gtataatgct    885

 ttgttaaaga accccctttc cgtgccactg gtgaataggg attgatgaat gggaagagtt    945

 gagtcagacc agtaagcccg tcctgggttc cttgaacatg ttcccatgta ggaggtaaaa   1005

 ccaattctgg aagtgtctat gaacttccat aaataacttt aattttagta taatgatggt   1065

 cttggattgt ctgacctcag tagctattaa ataacatcaa gtaacatctg tatcaggccc   1125

 tacatagaac atacagttga gtgggagtaa acaaaaagat aaacatgcgt gttaatggct   1185

 gttcgagaga aatcggaata aaagcctaaa caggaacaac ttcatcacag tgttgatgtt   1245

 ggacacatag atggtgatgg caaaggttta gaacacatta ttttcaaaga ctaaatctaa   1305

 aacccagagt aaacatcaat gctcagagtt agcataattt ggagctattc aggaattgca   1365

 gagaaatgca ttttcacaga aatcaagatg ttatttttgt atactatatc acttagacaa   1425

 ctgtgtttca tttgctgtaa tcagttttta aaagtcagat ggaaagagca actgaagtcc   1485

 tagaaaatag aaatgtaatt ttaaactatt ccaataaagc tggaggagga aggggagttt   1545

 gactaaagtt ctttttgttt gtttcaaatt ttcattaatg tatatagtgc aaaataccat   1605

 attaaagagg ggaatgtgga ggactgaaag ctgacagttt ggacttttct ttttgtactt   1665

 aagtcatgtc ttcaataatg aaaattgctg ttaaaaggat gtatgggatt tagatacttt   1725

 tgcaaagcta tagaaaattc actttgtaat ctgttataat aatgcccttg agttctgtgt   1785

 tcagtctgaa caggtttttt ggtggtggcg ccttattcct tagtgtttct aaaaaaactt   1845

 tgggagagaa aataaacaaa ctcttgactt aatttttaat tttgaagtgc aaaaagcagc   1905

 ttcggctttc aaagaaagtg attttaattt gctgaccaac cgaccctgtg tgaaataact   1965

 ttcccttttt                                                          1975




      <210> 18
      <211> 860
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (11)..(802)

      <400> 18
 gaccagcacc   atg gcg gtt ggc aag aac aag cgc ctt acg aaa ggc ggc      49
              Met Ala Val Gly Lys Asn Lys Arg Leu Thr Lys Gly Gly
                1               5                  10

 aaa aag gga gcc aag aag aaa gtg gtt gat cca ttt tct aag aaa gat       97
 Lys Lys Gly Ala Lys Lys Lys Val Val Asp Pro Phe Ser Lys Lys Asp
      15                  20                  25

 tgg tat gat gtg aaa gca cct gct atg ttc aat ata aga aat att gga      145
 Trp Tyr Asp Val Lys Ala Pro Ala Met Phe Asn Ile Arg Asn Ile Gly
  30                  35                  40                  45

 aag acg ctc gtc acc agg acc caa gga acc aaa att gca tct gat ggt      193
 Lys Thr Leu Val Thr Arg Thr Gln Gly Thr Lys Ile Ala Ser Asp Gly
                  50                  55                  60

 ctc aag ggt cgt gtg ttt gaa gtg agt ctt gct gat ttg cag aat gat      241
 Leu Lys Gly Arg Val Phe Glu Val Ser Leu Ala Asp Leu Gln Asn Asp
              65                  70                  75

 gaa gtt gca ttt aga aaa ttc aag ctg att act gaa gat gtt cag ggt      289
 Glu Val Ala Phe Arg Lys Phe Lys Leu Ile Thr Glu Asp Val Gln Gly
          80                  85                  90

 aaa aac tgc ctg act aac ttc cat ggc atg gat ctt acc cgt gac aaa      337
 Lys Asn Cys Leu Thr Asn Phe His Gly Met Asp Leu Thr Arg Asp Lys
      95                 100                 105

 atg tgt tcc atg gtc aaa aaa tgg cag aca atg att gaa gct cac gtt      385
 Met Cys Ser Met Val Lys Lys Trp Gln Thr Met Ile Glu Ala His Val
 110                 115                 120                 125

 gat gtc aag act acc gat ggt tac ttg ctt cgt ctg ttc tgt gtt ggt      433
 Asp Val Lys Thr Thr Asp Gly Tyr Leu Leu Arg Leu Phe Cys Val Gly
                 130                 135                 140

 ttt act aaa aaa cgc aac aat cag ata cgg aag acc tct tat gct cag      481
 Phe Thr Lys Lys Arg Asn Asn Gln Ile Arg Lys Thr Ser Tyr Ala Gln
             145                 150                 155

 cac caa cag gtc cgc caa atc cgg aag aag atg atg gaa atc atg acc      529
 His Gln Gln Val Arg Gln Ile Arg Lys Lys Met Met Glu Ile Met Thr
         160                 165                 170

 cga gag gtg cag aca aat gac ttg aaa gaa gtg gtc aat aaa ttg att      577
 Arg Glu Val Gln Thr Asn Asp Leu Lys Glu Val Val Asn Lys Leu Ile
     175                 180                 185

 cca gac agc att gga aaa gac ata gaa aag gct tgc caa tct att tat      625
 Pro Asp Ser Ile Gly Lys Asp Ile Glu Lys Ala Cys Gln Ser Ile Tyr
 190                 195                 200                 205

 cct ctc cat gat gtc ttc gtt aga aaa gta aaa atg ctg aag aag ccc      673
 Pro Leu His Asp Val Phe Val Arg Lys Val Lys Met Leu Lys Lys Pro
                 210                 215                 220

 aag ttt gaa ttg gga aag ctc atg gag ctt cat ggt gaa ggc agt agt      721
 Lys Phe Glu Leu Gly Lys Leu Met Glu Leu His Gly Glu Gly Ser Ser
             225                 230                 235

 tct gga aaa gcc act ggg gac gag aca ggt gct aaa gtt gaa cga gct      769
 Ser Gly Lys Ala Thr Gly Asp Glu Thr Gly Ala Lys Val Glu Arg Ala
         240                 245                 250

 gat gga tat gaa cca cca gtc caa gaa tct gtt taaagttc agacttcaaa      820
 Asp Gly Tyr Glu Pro Pro Val Gln Glu Ser Val 
     255                 260

 tagtggcaaa taaaaagtgc tatttgtgaa aaaaaaaaaa                          860




      <210> 19
      <211> 1042
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (97)..(975)

      <400> 19
 gtccagtgtg gtggaattcc gtcgtctcta tggtggcggc ggatttggag ggaccctacg     60

 aaccaggagt caggcgagcc gatctggggc tgcagg  atg ttc cgc tgg gag cgc     114
                                          Met Phe Arg Trp Glu Arg
                                            1               5

 tcc att ccc ctg cga ggc tcg gcc gcc gcc ctg tgc aac aac ctc agt      162
 Ser Ile Pro Leu Arg Gly Ser Ala Ala Ala Leu Cys Asn Asn Leu Ser
              10                  15                  20

 gtg ctg cag ctg ccg gct cgc aac ctc acg tat ttt ggc gtg gtt cat      210
 Val Leu Gln Leu Pro Ala Arg Asn Leu Thr Tyr Phe Gly Val Val His
          25                  30                  35

 gga cca agc gcc cag ctt ctc agc gct gct cct gag ggt gtg ccc ttg      258
 Gly Pro Ser Ala Gln Leu Leu Ser Ala Ala Pro Glu Gly Val Pro Leu
      40                  45                  50

 gcc cag cgc cag ctc cac gct aag gag ggt gct gga gtg agt ccc cca      306
 Ala Gln Arg Gln Leu His Ala Lys Glu Gly Ala Gly Val Ser Pro Pro
  55                  60                  65                  70

 ctt atc act cag gtc cac tgg tgt gtc ctc ccc ttc cga gtg ctg ctg      354
 Leu Ile Thr Gln Val His Trp Cys Val Leu Pro Phe Arg Val Leu Leu
                  75                  80                  85

 gta ctc acc tca cat cga gga ata cag atg tac gag tcc aat ggc tac      402
 Val Leu Thr Ser His Arg Gly Ile Gln Met Tyr Glu Ser Asn Gly Tyr
              90                  95                 100

 acc atg gtc tac tgg cat gca ctg gac tct gga gat gcc tcc cca gta      450
 Thr Met Val Tyr Trp His Ala Leu Asp Ser Gly Asp Ala Ser Pro Val
         105                 110                 115

 cag gct gtg ttt gcc cgg gga att gct gcc agt ggc cac ttc atc tgt      498
 Gln Ala Val Phe Ala Arg Gly Ile Ala Ala Ser Gly His Phe Ile Cys
     120                 125                 130

 gtg gga acg tgg tca ggc cgg gtg ctg gtg ttt gac atc cca gca aag      546
 Val Gly Thr Trp Ser Gly Arg Val Leu Val Phe Asp Ile Pro Ala Lys
 135                 140                 145                 150

 ggt ccc aac att gta ctg agc gag gag ctg gct ggg cac cag atg cca      594
 Gly Pro Asn Ile Val Leu Ser Glu Glu Leu Ala Gly His Gln Met Pro
                 155                 160                 165

 atc aca gac att gcc acc gag cct gcc cag gga cag ctg tgg cag ggg      642
 Ile Thr Asp Ile Ala Thr Glu Pro Ala Gln Gly Gln Leu Trp Gln Gly
             170                 175                 180

 atc ata gca gca ggc tat ggg aac gga caa gtg cat cta tat gag gcc      690
 Ile Ile Ala Ala Gly Tyr Gly Asn Gly Gln Val His Leu Tyr Glu Ala
         185                 190                 195

 act aca gga aat cta cat gtc cag atc aat gcc cat gcc cgg gcc atc      738
 Thr Thr Gly Asn Leu His Val Gln Ile Asn Ala His Ala Arg Ala Ile
     200                 205                 210

 tgc gcc ctg gac ctg gct ttt gag gtg ggc aag cta ctc tct gca ggt      786
 Cys Ala Leu Asp Leu Ala Phe Glu Val Gly Lys Leu Leu Ser Ala Gly
 215                 220                 225                 230

 gag gac acc ttt gtg cat atc tgg aag ctg agc aga aac cca gag agt      834
 Glu Asp Thr Phe Val His Ile Trp Lys Leu Ser Arg Asn Pro Glu Ser
                 235                 240                 245

 ggc tac att gag gtg gaa cac tgt cat ggt gag tgt gtc gcc gac acc      882
 Gly Tyr Ile Glu Val Glu His Cys His Gly Glu Cys Val Ala Asp Thr
             250                 255                 260

 cag ctg tgt ggt gct cga ttt tgt gat tcc tca ggc aac tcc ttt gct      930
 Gln Leu Cys Gly Ala Arg Phe Cys Asp Ser Ser Gly Asn Ser Phe Ala
         265                 270                 275

 gtg act ggc tat gac ctt gcg gag atc cgg aga ttc agc agt gtg tga      978
 Val Thr Gly Tyr Asp Leu Ala Glu Ile Arg Arg Phe Ser Ser Val 
     280                 285                 290

 gaagagcagc cttcctttgt ccctgtggta ttcataaagt acccgctccc cccaaaaaaa   1038

 aaaa                                                                1042




      <210> 20
      <211> 1111
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (97)..(1044)

      <400> 20
 gtccagtgtg gtggaattcc gtcgtctcta tggtggcggc ggatttggag ggaccctacg     60

 aaccaggagt caggcgagcc gatctggggc tgcagg  atg ttc cgc tgg gag cgc     114
                                          Met Phe Arg Trp Glu Arg
                                            1               5

 tcc att ccc ctg cga ggc tcg gcc gcc gcc ctg tgc aac aac ctc agt      162
 Ser Ile Pro Leu Arg Gly Ser Ala Ala Ala Leu Cys Asn Asn Leu Ser
              10                  15                  20

 gtg ctg cag ctg ccg gct cgc aac ctc acg tat ttt ggc gtg gtt cat      210
 Val Leu Gln Leu Pro Ala Arg Asn Leu Thr Tyr Phe Gly Val Val His
          25                  30                  35

 gga cca agc gcc cag ctt ctc agc gct gct cct gag ggt gtg ccc ttg      258
 Gly Pro Ser Ala Gln Leu Leu Ser Ala Ala Pro Glu Gly Val Pro Leu
      40                  45                  50

 gcc cag cgc cag ctc cac gct aag gag ggt gct gga gtg agt ccc cca      306
 Ala Gln Arg Gln Leu His Ala Lys Glu Gly Ala Gly Val Ser Pro Pro
  55                  60                  65                  70

 ctt atc act cag gtc cac tgg tgt gtc ctc ccc ttc cga gtg ctg ctg      354
 Leu Ile Thr Gln Val His Trp Cys Val Leu Pro Phe Arg Val Leu Leu
                  75                  80                  85

 gta ctc acc tca cat cga gga ata cag atg tac gag tcc aat ggc tac      402
 Val Leu Thr Ser His Arg Gly Ile Gln Met Tyr Glu Ser Asn Gly Tyr
              90                  95                 100

 acc atg gtc tac tgg cat gca ctg gac tct gga gat gcc tcc cca gga      450
 Thr Met Val Tyr Trp His Ala Leu Asp Ser Gly Asp Ala Ser Pro Gly
         105                 110                 115

 acg tgg tca ggc cgg gtg ctg gtg ttt gac atc cca gca aag ggt ccc      498
 Thr Trp Ser Gly Arg Val Leu Val Phe Asp Ile Pro Ala Lys Gly Pro
     120                 125                 130

 aac att gta ctg agc gag gag ctg gct ggg cac cag atg cca atc aca      546
 Asn Ile Val Leu Ser Glu Glu Leu Ala Gly His Gln Met Pro Ile Thr
 135                 140                 145                 150

 gac att gcc acc gag cct gcc cag gga cag gat tgt gtg gct gac atg      594
 Asp Ile Ala Thr Glu Pro Ala Gln Gly Gln Asp Cys Val Ala Asp Met
                 155                 160                 165

 gtg acg gca gat gac tca ggc ttg ctg tgt gtc tgg cgg tca ggg cca      642
 Val Thr Ala Asp Asp Ser Gly Leu Leu Cys Val Trp Arg Ser Gly Pro
             170                 175                 180

 gaa ttc aca tta ttg acc cgc att cca gga ttt gga gtt ccg tgc ccc      690
 Glu Phe Thr Leu Leu Thr Arg Ile Pro Gly Phe Gly Val Pro Cys Pro
         185                 190                 195

 tct gtg cag ctg tgg cag ggg atc ata gca gca ggc tat ggg aac gga      738
 Ser Val Gln Leu Trp Gln Gly Ile Ile Ala Ala Gly Tyr Gly Asn Gly
     200                 205                 210

 caa gtg cat cta tat gag gcc act aca gga aat cta cat gtc cag atc      786
 Gln Val His Leu Tyr Glu Ala Thr Thr Gly Asn Leu His Val Gln Ile
 215                 220                 225                 230

 aat gcc cat gcc cgg gcc atc tgc gcc ctg gac ctg gct ttt gag gtg      834
 Asn Ala His Ala Arg Ala Ile Cys Ala Leu Asp Leu Ala Phe Glu Val
                 235                 240                 245

 ggc aag cta ctc tct gca ggt gag gac acc ttt gtg cat atc tgg aag      882
 Gly Lys Leu Leu Ser Ala Gly Glu Asp Thr Phe Val His Ile Trp Lys
             250                 255                 260

 ctg agc aga aac cca gag agt ggc tac att gag gtg gaa cac tgt cat      930
 Leu Ser Arg Asn Pro Glu Ser Gly Tyr Ile Glu Val Glu His Cys His
         265                 270                 275

 ggt gag tgt gtc gcc gac acc cag ctg tgt ggt gct cga ttt tgt gat      978
 Gly Glu Cys Val Ala Asp Thr Gln Leu Cys Gly Ala Arg Phe Cys Asp
     280                 285                 290

 tcc tca ggc aac tcc ttt gct gtg act ggc tat gac ctt gcg gag atc     1026
 Ser Ser Gly Asn Ser Phe Ala Val Thr Gly Tyr Asp Leu Ala Glu Ile
 295                 300                 305                 310

 cgg aga ttc agc agt gtg tgagaa gagcagcctt cctttgtccc tgtggtattc     1080
 Arg Arg Phe Ser Ser Val 
                 315

 ataaagtacc cgctcccccc aaaaaaaaaa a                                  1111




      <210> 21
      <211> 1982
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (113)..(1051)

      <400> 21
 aatagtactc atcgctctgc ggaattcggc acgagatgct gccaacttct aaccgcaata     60

 gtgactctgt gcttgtctgt ttagttctgt gtataaatgg aatgttgtgg ag    atg     115
                                                              Met
                                                                1

 acc cct ccc tgt gcc ggc tgg ttc ctc tcc ctt ttc ccc tgg tca cgg      163
 Thr Pro Pro Cys Ala Gly Trp Phe Leu Ser Leu Phe Pro Trp Ser Arg
               5                  10                  15

 cta ctc atg gaa gca gga cca gta agg gac ctt cga tta aaa aaa aaa      211
 Leu Leu Met Glu Ala Gly Pro Val Arg Asp Leu Arg Leu Lys Lys Lys
          20                  25                  30

 aag gcc gtg cgg ccc atc acg gag cgc agc ctc ctg cag ggg gac gag      259
 Lys Ala Val Arg Pro Ile Thr Glu Arg Ser Leu Leu Gln Gly Asp Glu
      35                  40                  45

 att tgg aat gcc ctg aca gat aat tat ggg aat gtg atg cct gta gac      307
 Ile Trp Asn Ala Leu Thr Asp Asn Tyr Gly Asn Val Met Pro Val Asp
  50                  55                  60                  65

 tgg aag tca tcg cat act agg acc ttg cac ttg ctt act ctg aac ctc      355
 Trp Lys Ser Ser His Thr Arg Thr Leu His Leu Leu Thr Leu Asn Leu
                  70                  75                  80

 tca gaa aaa ggg gta agt gac agt ttg ctc ttt gat aca tca gat gat      403
 Ser Glu Lys Gly Val Ser Asp Ser Leu Leu Phe Asp Thr Ser Asp Asp
              85                  90                  95

 gaa gag ctg aga gaa cag ctg gat atg cac tca atc atc gtc tcc tgt      451
 Glu Glu Leu Arg Glu Gln Leu Asp Met His Ser Ile Ile Val Ser Cys
         100                 105                 110

 gtt aat gat gaa ccc ctc ttc acg gca gac cag gtt att gaa gaa att      499
 Val Asn Asp Glu Pro Leu Phe Thr Ala Asp Gln Val Ile Glu Glu Ile
     115                 120                 125

 gaa gaa atg atg cag gaa tca ccg gac cca gaa gat gat gaa acc cct      547
 Glu Glu Met Met Gln Glu Ser Pro Asp Pro Glu Asp Asp Glu Thr Pro
 130                 135                 140                 145

 aca cag tca gat cgg ctt tca atg ctt tcc cag gaa att caa act ctc      595
 Thr Gln Ser Asp Arg Leu Ser Met Leu Ser Gln Glu Ile Gln Thr Leu
                 150                 155                 160

 aag agg tct agt acc ggc agt tat gaa gag aga gtg aaa agg ctc tca      643
 Lys Arg Ser Ser Thr Gly Ser Tyr Glu Glu Arg Val Lys Arg Leu Ser
             165                 170                 175

 gtg tct gag tta aat gaa atc ctg gaa gaa att gag act gcc att aag      691
 Val Ser Glu Leu Asn Glu Ile Leu Glu Glu Ile Glu Thr Ala Ile Lys
         180                 185                 190

 gag tac tct gag gag ctg gtg cag cag ttg gct tta cga gat gaa ctg      739
 Glu Tyr Ser Glu Glu Leu Val Gln Gln Leu Ala Leu Arg Asp Glu Leu
     195                 200                 205

 gag ttt gaa aag gaa gtg aaa aac agc ttt att tct gtt ctt att gaa      787
 Glu Phe Glu Lys Glu Val Lys Asn Ser Phe Ile Ser Val Leu Ile Glu
 210                 215                 220                 225

 gtg caa aac aaa cag aaa gag cac aaa gaa aca gca aaa aag aaa aag      835
 Val Gln Asn Lys Gln Lys Glu His Lys Glu Thr Ala Lys Lys Lys Lys
                 230                 235                 240

 aaa cta aaa aat ggc agc tct cag aat ggg aag aat gag aga agt cat      883
 Lys Leu Lys Asn Gly Ser Ser Gln Asn Gly Lys Asn Glu Arg Ser His
             245                 250                 255

 atg ccc ggc aca tat ttg act aca gtc att cct tat gag aaa aaa aac      931
 Met Pro Gly Thr Tyr Leu Thr Thr Val Ile Pro Tyr Glu Lys Lys Asn
         260                 265                 270

 gga cca ccg tct gtt gaa gat ctt caa ata tta aca aaa att ctt cgt      979
 Gly Pro Pro Ser Val Glu Asp Leu Gln Ile Leu Thr Lys Ile Leu Arg
     275                 280                 285

 gcc atg aag gag gac agt gaa aaa gtt ccg agc ttg tta act gat tat     1027
 Ala Met Lys Glu Asp Ser Glu Lys Val Pro Ser Leu Leu Thr Asp Tyr
 290                 295                 300                 305

 att ctg aaa gtt ctg tgt cct aca tagagcagca actttatctg cggtgggctc    1081
 Ile Leu Lys Val Leu Cys Pro Thr 
                 310

 caagctagat ttccgacagc attattctga gagctggcta ccattaccct tcttgctatt   1141

 ggaaactcag cacatttgaa cttgggtttg attcagtatt aacagatctt gactacacta   1201

 attctttata ttatagaacc aacggaaata tgggcactat tttgaattct agagatggtt   1261

 tttgttaaat ctactaataa actgttctct tagtagatta agagagagta atattaattg   1321

 tgcatgtgca gttgtatttc tcattaactg acagtatgcc catttgtttt tatggctttc   1381

 ttatctaaac tgcactgatg aactagatta aagccttggg agatttatac tataaattca   1441

 gtgatgggca agaaccaaca ctgttttttt gtgaggaatt gtcagtgtaa ctattaccta   1501

 ccagtattgt tcagagagat tgaaacagga ataaacgggg ctgttcttgg aggaaggcaa   1561

 aaccagaata tggcattact ttggtttaat acttagtgct aacattgaaa ctgttggtgg   1621

 tgatggattt tgtagcttgc tgcttgtttc accactggtc aaattttaac cattaaattg   1681

 ccattcactt ttagaatctt gtatttaagt aagttttgat tttcaaatgt tctgcttcat   1741

 gtgtctgtga agaattgtac ttttttaaaa gtgtgtgtcc tctgaggtgc ttgagaaagt   1801

 gtacactgca gaactgccca ttctcattac tgtgtcctat tttattcatg cctgtgtgtt   1861

 tttcttaagt atgaattcta gatacagcta cttatggatt catcaatatc atgagcactt   1921

 ttgctggttc cagtcaaatc aatggcattt aataaatttt ttaagaagta aaaaaaaaaa   1981

 a                                                                   1982




      <210> 22
      <211> 2063
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (113)..(1132)

      <400> 22
 aatagtactc atcgctctgc ggaattcggc acgagatgct gccaacttct aaccgcaata     60

 gtgactctgt gcttgtctgt ttagttctgt gtataaatgg aatgttgtgg ag    atg     115
                                                              Met
                                                                1

 acc cct ccc tgt gcc ggc tgg ttc ctc tcc ctt ttc ccc tgg tca cgg      163
 Thr Pro Pro Cys Ala Gly Trp Phe Leu Ser Leu Phe Pro Trp Ser Arg
               5                  10                  15

 cta ctc atg gaa gca gga cca gta agg gac ctt cga tta aaa aaa aaa      211
 Leu Leu Met Glu Ala Gly Pro Val Arg Asp Leu Arg Leu Lys Lys Lys
          20                  25                  30

 aag gcc gtg cgg ccc atc acg gag cgc agc ctc ctg cag ggg gac gag      259
 Lys Ala Val Arg Pro Ile Thr Glu Arg Ser Leu Leu Gln Gly Asp Glu
      35                  40                  45

 att tgg aat gcc ctg aca gat aat tat ggg aat gtg atg cct gta gac      307
 Ile Trp Asn Ala Leu Thr Asp Asn Tyr Gly Asn Val Met Pro Val Asp
  50                  55                  60                  65

 tgg aag tca tcg cat act agg acc ttg cac ttg ctt act ctg aac ctc      355
 Trp Lys Ser Ser His Thr Arg Thr Leu His Leu Leu Thr Leu Asn Leu
                  70                  75                  80

 tca gaa aaa ggg gta agt gac agt ttg ctc ttt gat aca tca gat gat      403
 Ser Glu Lys Gly Val Ser Asp Ser Leu Leu Phe Asp Thr Ser Asp Asp
              85                  90                  95

 gaa gag ctg aga gaa cag ctg gat atg cac tca atc atc gtc tcc tgt      451
 Glu Glu Leu Arg Glu Gln Leu Asp Met His Ser Ile Ile Val Ser Cys
         100                 105                 110

 gtt aat gat gaa ccc ctc ttc acg gca gac cag gtt att gaa gaa att      499
 Val Asn Asp Glu Pro Leu Phe Thr Ala Asp Gln Val Ile Glu Glu Ile
     115                 120                 125

 gaa gaa atg atg cag gaa tca ccg gac cca gaa gat gat gaa acc cct      547
 Glu Glu Met Met Gln Glu Ser Pro Asp Pro Glu Asp Asp Glu Thr Pro
 130                 135                 140                 145

 aca cag tca gat cgg ctt tca atg ctt tcc cag gaa att caa act ctc      595
 Thr Gln Ser Asp Arg Leu Ser Met Leu Ser Gln Glu Ile Gln Thr Leu
                 150                 155                 160

 aag agg tct agt acc ggc agt tat gaa gag aga gtg aaa agg ctc tca      643
 Lys Arg Ser Ser Thr Gly Ser Tyr Glu Glu Arg Val Lys Arg Leu Ser
             165                 170                 175

 gtg tct gag tta aat gaa atc ctg gaa gaa att gag act gcc att aag      691
 Val Ser Glu Leu Asn Glu Ile Leu Glu Glu Ile Glu Thr Ala Ile Lys
         180                 185                 190

 gag tac tct gag gag ctg gtg cag cag ttg gct tta cga gat gaa ctg      739
 Glu Tyr Ser Glu Glu Leu Val Gln Gln Leu Ala Leu Arg Asp Glu Leu
     195                 200                 205

 gag ttt gaa aag gaa gtg aaa aac agc ttt att tct gtt ctt att gaa      787
 Glu Phe Glu Lys Glu Val Lys Asn Ser Phe Ile Ser Val Leu Ile Glu
 210                 215                 220                 225

 gtg caa aac aaa cag aaa gag cac aaa gaa aca gca aaa aag aaa aag      835
 Val Gln Asn Lys Gln Lys Glu His Lys Glu Thr Ala Lys Lys Lys Lys
                 230                 235                 240

 aaa cta aaa aat ggc agc tct cag aat ggg aag aat gag aga agt cat      883
 Lys Leu Lys Asn Gly Ser Ser Gln Asn Gly Lys Asn Glu Arg Ser His
             245                 250                 255

 atg ccc ggc aca cgc ttc agc atg gaa ggg atc tca aat gtc att cag      931
 Met Pro Gly Thr Arg Phe Ser Met Glu Gly Ile Ser Asn Val Ile Gln
         260                 265                 270

 aat ggc ctc cgc cac acc ttt gga aat tca ggt gga gag aaa cag tat      979
 Asn Gly Leu Arg His Thr Phe Gly Asn Ser Gly Gly Glu Lys Gln Tyr
     275                 280                 285

 ttg act aca gtc att cct tat gag aaa aaa aac gga cca ccg tct gtt     1027
 Leu Thr Thr Val Ile Pro Tyr Glu Lys Lys Asn Gly Pro Pro Ser Val
 290                 295                 300                 305

 gaa gat ctt caa ata tta aca aaa att ctt cgt gcc atg aag gag gac     1075
 Glu Asp Leu Gln Ile Leu Thr Lys Ile Leu Arg Ala Met Lys Glu Asp
                 310                 315                 320

 agt gaa aaa gtt ccg agc ttg tta act gat tat att ctg aaa gtt ctg     1123
 Ser Glu Lys Val Pro Ser Leu Leu Thr Asp Tyr Ile Leu Lys Val Leu
             325                 330                 335

 tgt cct aca tagagca gcaactttat ctgcggtggg ctccaagcta gatttccgac     1179
 Cys Pro Thr 
         340

 agcattattc tgagagctgg ctaccattac ccttcttgct attggaaact cagcacattt   1239

 gaacttgggt ttgattcagt attaacagat cttgactaca ctaattcttt atattataga   1299

 accaacggaa atatgggcac tattttgaat tctagagatg gtttttgtta aatctactaa   1359

 taaactgttc tcttagtaga ttaagagaga gtaatattaa ttgtgcatgt gcagttgtat   1419

 ttctcattaa ctgacagtat gcccatttgt ttttatggct ttcttatcta aactgcactg   1479

 atgaactaga ttaaagcctt gggagattta tactataaat tcagtgatgg gcaagaacca   1539

 acactgtttt tttgtgagga attgtcagtg taactattac ctaccagtat tgttcagaga   1599

 gattgaaaca ggaataaacg gggctgttct tggaggaagg caaaaccaga atatggcatt   1659

 actttggttt aatacttagt gctaacattg aaactgttgg tggtgatgga ttttgtagct   1719

 tgctgcttgt ttcaccactg gtcaaatttt aaccattaaa ttgccattca cttttagaat   1779

 cttgtattta agtaagtttt gattttcaaa tgttctgctt catgtgtctg tgaagaattg   1839

 tactttttta aaagtgtgtg tcctctgagg tgcttgagaa agtgtacact gcagaactgc   1899

 ccattctcat tactgtgtcc tattttattc atgcctgtgt gtttttctta agtatgaatt   1959

 ctagatacag ctacttatgg attcatcaat atcatgagca cttttgctgg ttccagtcaa   2019

 atcaatggca tttaataaat tttttaagaa gtaaaaaaaa aaaa                    2063




      <210> 23
      <211> 2079
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (148)..(1728)

      <400> 23
 cgtgcaggaa ccgcggctgc tggacaagag gggtgcggtg gatactgacc tttgctccgg     60

 cctcgtgtag cgtgaagaca cagcgcatct ccccgctgta ggcttcctcc cacagaaccc    120

 gtttcgggcc tcagagcgtc tggtgag    atg ctg ttg ccg ctg ctg ctg ctg     171
                                  Met Leu Leu Pro Leu Leu Leu Leu
                                    1               5

 cta ccc atg tgc tgg gcc gtg gag gtc aag agg ccc cgg ggc gtc tcc      219
 Leu Pro Met Cys Trp Ala Val Glu Val Lys Arg Pro Arg Gly Val Ser
      10                  15                  20

 ctc acc aat cat cac ttc tac gat gag tcc aag cct ttc acc tgc ctg      267
 Leu Thr Asn His His Phe Tyr Asp Glu Ser Lys Pro Phe Thr Cys Leu
  25                  30                  35                  40

 gac ggt tcg gcc acc atc cca ttt gat cag gtc aac gat gac tat tgc      315
 Asp Gly Ser Ala Thr Ile Pro Phe Asp Gln Val Asn Asp Asp Tyr Cys
                  45                  50                  55

 gac tgc aaa gat ggc tct gac gag cca ggc acg gct gcc tgt cct aat      363
 Asp Cys Lys Asp Gly Ser Asp Glu Pro Gly Thr Ala Ala Cys Pro Asn
              60                  65                  70

 ggc agc ttc cac tgc acc aac act ggc tat aag ccc ctg tat atc ccc      411
 Gly Ser Phe His Cys Thr Asn Thr Gly Tyr Lys Pro Leu Tyr Ile Pro
          75                  80                  85

 tcc aac cgg gtc aac gat ggt gtt tgt gac tgc tgc gat gga aca gac      459
 Ser Asn Arg Val Asn Asp Gly Val Cys Asp Cys Cys Asp Gly Thr Asp
      90                  95                 100

 gag tac aac agc ggc gtc atc tgt gag aac acc tgc aaa gag aag ggc      507
 Glu Tyr Asn Ser Gly Val Ile Cys Glu Asn Thr Cys Lys Glu Lys Gly
 105                 110                 115                 120

 cgt aag gag aga gag tcc ctg cag cag atg gcc gag gtc acc cgc gaa      555
 Arg Lys Glu Arg Glu Ser Leu Gln Gln Met Ala Glu Val Thr Arg Glu
                 125                 130                 135

 ggg ttc cgt ctg aag aag atc ctt att gag gac tgg aag aag gca cgg      603
 Gly Phe Arg Leu Lys Lys Ile Leu Ile Glu Asp Trp Lys Lys Ala Arg
             140                 145                 150

 gag gag aag cag aaa aag ctc att gag cta cag gct ggg aag aag tct      651
 Glu Glu Lys Gln Lys Lys Leu Ile Glu Leu Gln Ala Gly Lys Lys Ser
         155                 160                 165

 ctg gaa gac cag gtg gag atg ctg cgg aca gtg aag gag gaa gct gag      699
 Leu Glu Asp Gln Val Glu Met Leu Arg Thr Val Lys Glu Glu Ala Glu
     170                 175                 180

 aag cca gag aga gag gcc aaa gag cag cac cag aag ctg tgg gaa gag      747
 Lys Pro Glu Arg Glu Ala Lys Glu Gln His Gln Lys Leu Trp Glu Glu
 185                 190                 195                 200

 cag ctg gct gct gcc aag gcc caa cag gag cag gag ctg gcg gct gat      795
 Gln Leu Ala Ala Ala Lys Ala Gln Gln Glu Gln Glu Leu Ala Ala Asp
                 205                 210                 215

 gcc ttc aag gag ctg gat gat gac atg gac ggg acg gtc tcg gtg act      843
 Ala Phe Lys Glu Leu Asp Asp Asp Met Asp Gly Thr Val Ser Val Thr
             220                 225                 230

 gag ctg cag act cac ccg gag ctg gac aca gat ggg gat ggg gcg ttg      891
 Glu Leu Gln Thr His Pro Glu Leu Asp Thr Asp Gly Asp Gly Ala Leu
         235                 240                 245

 tca gaa gcg gaa gct cag gcc ctc ctc agt ggg gac aca cag aca gac      939
 Ser Glu Ala Glu Ala Gln Ala Leu Leu Ser Gly Asp Thr Gln Thr Asp
     250                 255                 260

 gcc acc tct ttc tac gac cgc gtc tgg gcc gcc atc agg gac aag tac      987
 Ala Thr Ser Phe Tyr Asp Arg Val Trp Ala Ala Ile Arg Asp Lys Tyr
 265                 270                 275                 280

 cgg tcc gag gca ctg ccc acc gac ctt cca gca cct tct gcc cct gac     1035
 Arg Ser Glu Ala Leu Pro Thr Asp Leu Pro Ala Pro Ser Ala Pro Asp
                 285                 290                 295

 ttg acg gag ccc aag gag gag cag ccg cca gtg ccc tcg tcg ccc aca     1083
 Leu Thr Glu Pro Lys Glu Glu Gln Pro Pro Val Pro Ser Ser Pro Thr
             300                 305                 310

 gag gag gag gag gag gag gag gag gag gaa gaa gag gct gaa gaa gag     1131
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Glu Glu Glu
         315                 320                 325

 gag gag gag gag gat tcc gag gag gcc cca ccg cca ctg tca ccc ccg     1179
 Glu Glu Glu Glu Asp Ser Glu Glu Ala Pro Pro Pro Leu Ser Pro Pro
     330                 335                 340

 cag ccg gcc agc cct gct gag gaa gac aaa atg ccg ccc tac gac gag     1227
 Gln Pro Ala Ser Pro Ala Glu Glu Asp Lys Met Pro Pro Tyr Asp Glu
 345                 350                 355                 360

 cag acg cag gcc ttc atc gat gct gcc cag gag gcc cgc aac aag ttc     1275
 Gln Thr Gln Ala Phe Ile Asp Ala Ala Gln Glu Ala Arg Asn Lys Phe
                 365                 370                 375

 gag gag gcc gag cgg tcg ctg aag gac atg gag gag tcc atc agg aac     1323
 Glu Glu Ala Glu Arg Ser Leu Lys Asp Met Glu Glu Ser Ile Arg Asn
             380                 385                 390

 ctg gag caa gag att tct ttt gac ttt ggc ccc aac ggg gag ttt gct     1371
 Leu Glu Gln Glu Ile Ser Phe Asp Phe Gly Pro Asn Gly Glu Phe Ala
         395                 400                 405

 tac ctg tac agc cag tgc tac gag ctc acc acc aac gaa tac gtc tac     1419
 Tyr Leu Tyr Ser Gln Cys Tyr Glu Leu Thr Thr Asn Glu Tyr Val Tyr
     410                 415                 420

 cgc ctc tgc ccc ttc aag ctt gtc tcg cag aaa ccc aaa ctc ggg ggc     1467
 Arg Leu Cys Pro Phe Lys Leu Val Ser Gln Lys Pro Lys Leu Gly Gly
 425                 430                 435                 440

 tct ccc acc agc ctt ggc acc tgg ggc tca tgg att ggc ccc gac cac     1515
 Ser Pro Thr Ser Leu Gly Thr Trp Gly Ser Trp Ile Gly Pro Asp His
                 445                 450                 455

 gac aag ttc agt gcc atg aag tat gag caa ggc acg ggc tgc tgg cag     1563
 Asp Lys Phe Ser Ala Met Lys Tyr Glu Gln Gly Thr Gly Cys Trp Gln
             460                 465                 470

 ggc ccc aac cgc tcc acc acc gtg cgc ctc ctg tgc ggg aaa gag acc     1611
 Gly Pro Asn Arg Ser Thr Thr Val Arg Leu Leu Cys Gly Lys Glu Thr
         475                 480                 485

 atg gtg acc agc acc aca gag ccc agt cgc tgc gag tac ctc atg gag     1659
 Met Val Thr Ser Thr Thr Glu Pro Ser Arg Cys Glu Tyr Leu Met Glu
     490                 495                 500

 ctg atg acg cca gcc gcc tgc ccg gag cca ccg cct gaa gca ccc acc     1707
 Leu Met Thr Pro Ala Ala Cys Pro Glu Pro Pro Pro Glu Ala Pro Thr
 505                 510                 515                 520

 gaa gac gac cat gac gag ctc ta gctggatggg cgcagagaac cttcaagaag     1760
 Glu Asp Asp His Asp Glu Leu 
                 525

 gcatgaagcc agcccctgca gtgccgtcca cccgcccctc tgggcctgcc tgtggctctg   1820

 ttgccctcct ctgtggcggc aggacctttg tggggcttcg tgccctgctc tggggcccag   1880

 gcggggctgg tccacattcc caggccccaa cagccttcaa agatgggtaa aggagcttgc   1940

 cctccctggg ccccccacct tggtgactcg ccccaccacc cccagccctg tccctgccac   2000

 ccctcctagt ggggactagt gaatgacttg acctgtgacc tcaatacaat aaatgtgatc   2060

 ccccacccca aaaaaaaaa                                                2079




      <210> 24
      <211> 2068
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (146)..(1717)

      <400> 24
 tgcaggaacc gcggctgctg gacaagaggg gtgcggtgga tactgacctt tgctccggcc     60

 tcgtgtagcg tgaagacaca gcgcatctcc ccgctgtagg cttcctccca cagaacccgt    120

 ttcgggcctc agagcgtctg gtgag  atg ctg ttg ccg ctg ctg ctg ctg cta     172
                              Met Leu Leu Pro Leu Leu Leu Leu Leu
                                1               5

 ccc atg tgc tgg gcc gtg gag gtc aag agg ccc cgg ggc gtc tcc ctc      220
 Pro Met Cys Trp Ala Val Glu Val Lys Arg Pro Arg Gly Val Ser Leu
  10                  15                  20                  25

 acc aat cat cac ttc tac gat gag tcc aag cct ttc acc tgc ctg gac      268
 Thr Asn His His Phe Tyr Asp Glu Ser Lys Pro Phe Thr Cys Leu Asp
                  30                  35                  40

 ggt tcg gcc acc atc cca ttt gat cag gtc aac gat gac tat tgc gac      316
 Gly Ser Ala Thr Ile Pro Phe Asp Gln Val Asn Asp Asp Tyr Cys Asp
              45                  50                  55

 tgc aaa gat ggc tct gac gag cca ggc acg gct gcc tgt cct aat ggc      364
 Cys Lys Asp Gly Ser Asp Glu Pro Gly Thr Ala Ala Cys Pro Asn Gly
          60                  65                  70

 agc ttc cac tgc acc aac act ggc tat aag ccc ctg tat atc ccc tcc      412
 Ser Phe His Cys Thr Asn Thr Gly Tyr Lys Pro Leu Tyr Ile Pro Ser
      75                  80                  85

 aac cgg gtc aac gat ggt gtt tgt gac tgc tgc gat gga aca gac gag      460
 Asn Arg Val Asn Asp Gly Val Cys Asp Cys Cys Asp Gly Thr Asp Glu
  90                  95                 100                 105

 tac aac agc ggc gtc atc tgt gag aac acc tgc aaa gag aag ggc cgt      508
 Tyr Asn Ser Gly Val Ile Cys Glu Asn Thr Cys Lys Glu Lys Gly Arg
                 110                 115                 120

 aag gag aga gag tcc ctg cag cag atg gcc gag gtc acc cgc gaa ggg      556
 Lys Glu Arg Glu Ser Leu Gln Gln Met Ala Glu Val Thr Arg Glu Gly
             125                 130                 135

 ttc cgt ctg aag aag atc ctt att gag gac tgg aag aag gca cgg gag      604
 Phe Arg Leu Lys Lys Ile Leu Ile Glu Asp Trp Lys Lys Ala Arg Glu
         140                 145                 150

 gag aag cag aaa aag ctc att gag cta cag gct ggg aag aag tct ctg      652
 Glu Lys Gln Lys Lys Leu Ile Glu Leu Gln Ala Gly Lys Lys Ser Leu
     155                 160                 165

 gaa gac cag gtg gag atg ctg cgg aca gtg aag gag gaa gct gag aag      700
 Glu Asp Gln Val Glu Met Leu Arg Thr Val Lys Glu Glu Ala Glu Lys
 170                 175                 180                 185

 cca gag aga gag gcc aaa gag cag cac cag aag ctg tgg gaa gag cag      748
 Pro Glu Arg Glu Ala Lys Glu Gln His Gln Lys Leu Trp Glu Glu Gln
                 190                 195                 200

 ctg gct gct gcc aag gcc caa cag gag cag gag ctg gcg gct gat gcc      796
 Leu Ala Ala Ala Lys Ala Gln Gln Glu Gln Glu Leu Ala Ala Asp Ala
             205                 210                 215

 ttc aag gag ctg gat gat gac atg gac ggg acg gtc tcg gtg act gag      844
 Phe Lys Glu Leu Asp Asp Asp Met Asp Gly Thr Val Ser Val Thr Glu
         220                 225                 230

 ctg cag act cac ccg gag ctg gac aca gat ggg gat ggg gcg ttg tca      892
 Leu Gln Thr His Pro Glu Leu Asp Thr Asp Gly Asp Gly Ala Leu Ser
     235                 240                 245

 gaa gcg gaa gct cag gcc ctc ctc agt ggg gac aca cag aca gac gcc      940
 Glu Ala Glu Ala Gln Ala Leu Leu Ser Gly Asp Thr Gln Thr Asp Ala
 250                 255                 260                 265

 acc tct ttc tac gac cgc gtc tgg gcc gcc atc agg gac aag tac cgg      988
 Thr Ser Phe Tyr Asp Arg Val Trp Ala Ala Ile Arg Asp Lys Tyr Arg
                 270                 275                 280

 tcc gag gca ctg ccc acc gac ctt cca gca cct tct gcc cct gac ttg     1036
 Ser Glu Ala Leu Pro Thr Asp Leu Pro Ala Pro Ser Ala Pro Asp Leu
             285                 290                 295

 acg gag ccc aag gag gag cag ccg cca gtg ccc tcg tcg ccc aca gag     1084
 Thr Glu Pro Lys Glu Glu Gln Pro Pro Val Pro Ser Ser Pro Thr Glu
         300                 305                 310

 gag gag gag gag gag gag gag gag gaa gaa gag gct gaa gaa gag gag     1132
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Glu Glu Glu Glu
     315                 320                 325

 gag gag gag gat tcc gag gtg cag ggg gag cag ccc aag ccg gcc agc     1180
 Glu Glu Glu Asp Ser Glu Val Gln Gly Glu Gln Pro Lys Pro Ala Ser
 330                 335                 340                 345

 cct gct gag gaa gac aaa atg ccg ccc tac gac gag cag acg cag gcc     1228
 Pro Ala Glu Glu Asp Lys Met Pro Pro Tyr Asp Glu Gln Thr Gln Ala
                 350                 355                 360

 ttc atc gat gct gcc cag gag gcc cgc aac aag ttc gag gag gcc gag     1276
 Phe Ile Asp Ala Ala Gln Glu Ala Arg Asn Lys Phe Glu Glu Ala Glu
             365                 370                 375

 cgg tcg ctg aag gac atg gag gag tcc atc agg aac ctg gag caa gag     1324
 Arg Ser Leu Lys Asp Met Glu Glu Ser Ile Arg Asn Leu Glu Gln Glu
         380                 385                 390

 att tct ttt gac ttt ggc ccc aac ggg gag ttt gct tac ctg tac agc     1372
 Ile Ser Phe Asp Phe Gly Pro Asn Gly Glu Phe Ala Tyr Leu Tyr Ser
     395                 400                 405

 cag tgc tac gag ctc acc acc aac gaa tac gtc tac cgc ctc tgc ccc     1420
 Gln Cys Tyr Glu Leu Thr Thr Asn Glu Tyr Val Tyr Arg Leu Cys Pro
 410                 415                 420                 425

 ttc aag ctt gtc tcg cag aaa ccc aaa ctc ggg ggc tct ccc acc agc     1468
 Phe Lys Leu Val Ser Gln Lys Pro Lys Leu Gly Gly Ser Pro Thr Ser
                 430                 435                 440

 ctt ggc acc tgg ggc tca tgg att ggc ccc gac cac gac aag ttc agt     1516
 Leu Gly Thr Trp Gly Ser Trp Ile Gly Pro Asp His Asp Lys Phe Ser
             445                 450                 455

 gcc atg aag tat gag caa ggc acg ggc tgc tgg cag ggc ccc aac cgc     1564
 Ala Met Lys Tyr Glu Gln Gly Thr Gly Cys Trp Gln Gly Pro Asn Arg
         460                 465                 470

 tcc acc acc gtg cgc ctc ctg tgc ggg aaa gag acc atg gtg acc agc     1612
 Ser Thr Thr Val Arg Leu Leu Cys Gly Lys Glu Thr Met Val Thr Ser
     475                 480                 485

 acc aca gag ccc agt cgc tgc gag tac ctc atg gag ctg atg acg cca     1660
 Thr Thr Glu Pro Ser Arg Cys Glu Tyr Leu Met Glu Leu Met Thr Pro
 490                 495                 500                 505

 gcc gcc tgc ccg gag cca ccg cct gaa gca ccc acc gaa gac gac cat     1708
 Ala Ala Cys Pro Glu Pro Pro Pro Glu Ala Pro Thr Glu Asp Asp His
                 510                 515                 520

 gac gag ctc tagctgg atgggcgcag agaaccttca agaaggcatg aagccagccc     1764
 Asp Glu Leu 


 ctgcagtgcc gtccacccgc ccctctgggc ctgcctgtgg ctctgttgcc ctcctctgtg   1824

 gcggcaggac ctttgtgggg cttcgtgccc tgctctgggg cccaggcggg gctggtccac   1884

 attcccaggc cccaacagcc ttcaaagatg ggtaaaggag cttgccctcc ctgggccccc   1944

 caccttggtg actcgcccca ccacccccag ccctgtccct gccacccctc ctagtgggga   2004

 ctagtgaatg acttgacctg tgacctcaat acaataaatg tgatccccca ccccaaaaaa   2064

 aaaa                                                                2068




      <210> 25
      <211> 2098
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (146)..(1747)

      <400> 25
 tgcaggaacc gcggctgctg gacaagaggg gtgcggtgga tactgacctt tgctccggcc     60

 tcgtgtagcg tgaagacaca gcgcatctcc ccgctgtagg cttcctccca cagaacccgt    120

 ttcgggcctc agagcgtctg gtgag  atg ctg ttg ccg ctg ctg ctg ctg cta     172
                              Met Leu Leu Pro Leu Leu Leu Leu Leu
                                1               5

 ccc atg tgc tgg gcc gtg gag gtc aag agg ccc cgg ggc gtc tcc ctc      220
 Pro Met Cys Trp Ala Val Glu Val Lys Arg Pro Arg Gly Val Ser Leu
  10                  15                  20                  25

 acc aat cat cac ttc tac gat gag tcc aag cct ttc acc tgc ctg gac      268
 Thr Asn His His Phe Tyr Asp Glu Ser Lys Pro Phe Thr Cys Leu Asp
                  30                  35                  40

 ggt tcg gcc acc atc cca ttt gat cag gtc aac gat gac tat tgc gac      316
 Gly Ser Ala Thr Ile Pro Phe Asp Gln Val Asn Asp Asp Tyr Cys Asp
              45                  50                  55

 tgc aaa gat ggc tct gac gag cca ggc acg gct gcc tgt cct aat ggc      364
 Cys Lys Asp Gly Ser Asp Glu Pro Gly Thr Ala Ala Cys Pro Asn Gly
          60                  65                  70

 agc ttc cac tgc acc aac act ggc tat aag ccc ctg tat atc ccc tcc      412
 Ser Phe His Cys Thr Asn Thr Gly Tyr Lys Pro Leu Tyr Ile Pro Ser
      75                  80                  85

 aac cgg gtc aac gat ggt gtt tgt gac tgc tgc gat gga aca gac gag      460
 Asn Arg Val Asn Asp Gly Val Cys Asp Cys Cys Asp Gly Thr Asp Glu
  90                  95                 100                 105

 tac aac agc ggc gtc atc tgt gag aac acc tgc aaa gag aag ggc cgt      508
 Tyr Asn Ser Gly Val Ile Cys Glu Asn Thr Cys Lys Glu Lys Gly Arg
                 110                 115                 120

 aag gag aga gag tcc ctg cag cag atg gcc gag gtc acc cgc gaa ggg      556
 Lys Glu Arg Glu Ser Leu Gln Gln Met Ala Glu Val Thr Arg Glu Gly
             125                 130                 135

 ttc cgt ctg aag aag atc ctt att gag gac tgg aag aag gca cgg gag      604
 Phe Arg Leu Lys Lys Ile Leu Ile Glu Asp Trp Lys Lys Ala Arg Glu
         140                 145                 150

 gag aag cag aaa aag ctc att gag cta cag gct ggg aag aag tct ctg      652
 Glu Lys Gln Lys Lys Leu Ile Glu Leu Gln Ala Gly Lys Lys Ser Leu
     155                 160                 165

 gaa gac cag gtg gag atg ctg cgg aca gtg aag gag gaa gct gag aag      700
 Glu Asp Gln Val Glu Met Leu Arg Thr Val Lys Glu Glu Ala Glu Lys
 170                 175                 180                 185

 cca gag aga gag gcc aaa gag cag cac cag aag ctg tgg gaa gag cag      748
 Pro Glu Arg Glu Ala Lys Glu Gln His Gln Lys Leu Trp Glu Glu Gln
                 190                 195                 200

 ctg gct gct gcc aag gcc caa cag gag cag gag ctg gcg gct gat gcc      796
 Leu Ala Ala Ala Lys Ala Gln Gln Glu Gln Glu Leu Ala Ala Asp Ala
             205                 210                 215

 ttc aag gag ctg gat gat gac atg gac ggg acg gtc tcg gtg act gag      844
 Phe Lys Glu Leu Asp Asp Asp Met Asp Gly Thr Val Ser Val Thr Glu
         220                 225                 230

 ctg cag act cac ccg gag ctg gac aca gat ggg gat ggg gcg ttg tca      892
 Leu Gln Thr His Pro Glu Leu Asp Thr Asp Gly Asp Gly Ala Leu Ser
     235                 240                 245

 gaa gcg gaa gct cag gcc ctc ctc agt ggg gac aca cag aca gac gcc      940
 Glu Ala Glu Ala Gln Ala Leu Leu Ser Gly Asp Thr Gln Thr Asp Ala
 250                 255                 260                 265

 acc tct ttc tac gac cgc gtc tgg gcc gcc atc agg gac aag tac cgg      988
 Thr Ser Phe Tyr Asp Arg Val Trp Ala Ala Ile Arg Asp Lys Tyr Arg
                 270                 275                 280

 tcc gag gca ctg ccc acc gac ctt cca gca cct tct gcc cct gac ttg     1036
 Ser Glu Ala Leu Pro Thr Asp Leu Pro Ala Pro Ser Ala Pro Asp Leu
             285                 290                 295

 acg gag ccc aag gag gag cag ccg cca gtg ccc tcg tcg ccc aca gag     1084
 Thr Glu Pro Lys Glu Glu Gln Pro Pro Val Pro Ser Ser Pro Thr Glu
         300                 305                 310

 gag gag gag gag gag gag gag gag gaa gaa gag gct gaa gaa gag gag     1132
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Glu Glu Glu Glu
     315                 320                 325

 gag gag gag gat tcc gag gtg cag ggg gag cag ccc aag gag gcc cca     1180
 Glu Glu Glu Asp Ser Glu Val Gln Gly Glu Gln Pro Lys Glu Ala Pro
 330                 335                 340                 345

 ccg cca ctg tca ccc ccg cag ccg gcc agc cct gct gag gaa gac aaa     1228
 Pro Pro Leu Ser Pro Pro Gln Pro Ala Ser Pro Ala Glu Glu Asp Lys
                 350                 355                 360

 atg ccg ccc tac gac gag cag acg cag gcc ttc atc gat gct gcc cag     1276
 Met Pro Pro Tyr Asp Glu Gln Thr Gln Ala Phe Ile Asp Ala Ala Gln
             365                 370                 375

 gag gcc cgc aac aag ttc gag gag gcc gag cgg tcg ctg aag gac atg     1324
 Glu Ala Arg Asn Lys Phe Glu Glu Ala Glu Arg Ser Leu Lys Asp Met
         380                 385                 390

 gag gag tcc atc agg aac ctg gag caa gag att tct ttt gac ttt ggc     1372
 Glu Glu Ser Ile Arg Asn Leu Glu Gln Glu Ile Ser Phe Asp Phe Gly
     395                 400                 405

 ccc aac ggg gag ttt gct tac ctg tac agc cag tgc tac gag ctc acc     1420
 Pro Asn Gly Glu Phe Ala Tyr Leu Tyr Ser Gln Cys Tyr Glu Leu Thr
 410                 415                 420                 425

 acc aac gaa tac gtc tac cgc ctc tgc ccc ttc aag ctt gtc tcg cag     1468
 Thr Asn Glu Tyr Val Tyr Arg Leu Cys Pro Phe Lys Leu Val Ser Gln
                 430                 435                 440

 aaa ccc aaa ctc ggg ggc tct ccc acc agc ctt ggc acc tgg ggc tca     1516
 Lys Pro Lys Leu Gly Gly Ser Pro Thr Ser Leu Gly Thr Trp Gly Ser
             445                 450                 455

 tgg att ggc ccc gac cac gac aag ttc agt gcc atg aag tat gag caa     1564
 Trp Ile Gly Pro Asp His Asp Lys Phe Ser Ala Met Lys Tyr Glu Gln
         460                 465                 470

 ggc acg ggc tgc tgg cag ggc ccc aac cgc tcc acc acc gtg cgc ctc     1612
 Gly Thr Gly Cys Trp Gln Gly Pro Asn Arg Ser Thr Thr Val Arg Leu
     475                 480                 485

 ctg tgc ggg aaa gag acc atg gtg acc agc acc aca gag ccc agt cgc     1660
 Leu Cys Gly Lys Glu Thr Met Val Thr Ser Thr Thr Glu Pro Ser Arg
 490                 495                 500                 505

 tgc gag tac ctc atg gag ctg atg acg cca gcc gcc tgc ccg gag cca     1708
 Cys Glu Tyr Leu Met Glu Leu Met Thr Pro Ala Ala Cys Pro Glu Pro
                 510                 515                 520

 ccg cct gaa gca ccc acc gaa gac gac cat gac gag ctc tagctggatg      1757
 Pro Pro Glu Ala Pro Thr Glu Asp Asp His Asp Glu Leu 
             525                 530

 ggcgcagaga accttcaaga aggcatgaag ccagcccctg cagtgccgtc cacccgcccc   1817

 tctgggcctg cctgtggctc tgttgccctc ctctgtggcg gcaggacctt tgtggggctt   1877

 cgtgccctgc tctggggccc aggcggggct ggtccacatt cccaggcccc aacagccttc   1937

 aaagatgggt aaaggagctt gccctccctg ggccccccac cttggtgact cgccccacca   1997

 cccccagccc tgtccctgcc acccctccta gtggggacta gtgaatgact tgacctgtga   2057

 cctcaataca ataaatgtga tcccccaccc caaaaaaaaa a                       2098




      <210> 26
      <211> 1356
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (41)..(1198)

      <400> 26
 tgtggctgtg ccgttggtcc tgtgcggtca cttagccaag  atg cct gag gaa acc      55
                                              Met Pro Glu Glu Thr
                                                1               5

 cag acc caa gac caa ccg atg gag gag gag gag gtt gag acg ttc gcc      103
 Gln Thr Gln Asp Gln Pro Met Glu Glu Glu Glu Val Glu Thr Phe Ala
                  10                  15                  20

 ttt cag gca gaa att gcc cag ttg atg tca ttg atc atc aat act ttc      151
 Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile Ile Asn Thr Phe
              25                  30                  35

 tac tcg aac aaa gag atc ttt ctg aga gag ctc att tca aat tca tca      199
 Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ser Ser
          40                  45                  50

 gat gca ttg gac aaa atc cgg tat gaa agc ttg aca gat ccc agt aaa      247
 Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu Thr Asp Pro Ser Lys
      55                  60                  65

 tta gac tct ggg aaa gag ctg cat att aac ctt ata ccg aac aaa caa      295
 Leu Asp Ser Gly Lys Glu Leu His Ile Asn Leu Ile Pro Asn Lys Gln
  70                  75                  80                  85

 gat cga act ctc act att gtg gat act gga att gga atg acc aag gct      343
 Asp Arg Thr Leu Thr Ile Val Asp Thr Gly Ile Gly Met Thr Lys Ala
                  90                  95                 100

 gac ttg atc aat aac ctt ggt act atc gcc aag tct ggg acc aaa gcg      391
 Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Lys Ala
             105                 110                 115

 ttc atg gaa gct ttg cag gct ggt gca gat atc tct atg att ggc cag      439
 Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser Met Ile Gly Gln
         120                 125                 130

 ttc ggt gtt ggt ttt tat tct gct tat ttg gtt gct gag aaa gta act      487
 Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala Glu Lys Val Thr
     135                 140                 145

 gtg atc acc aaa cat aac gat gat gag cag tac gct tgg gag tcc tca      535
 Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala Trp Glu Ser Ser
 150                 155                 160                 165

 gca ggg gga tca ttc aca gtg agg aca gac aca ggt gaa cct atg ggt      583
 Ala Gly Gly Ser Phe Thr Val Arg Thr Asp Thr Gly Glu Pro Met Gly
                 170                 175                 180

 cgt gga aca aaa gtt atc cta cac ctg aaa gaa gac caa act gag tac      631
 Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp Gln Thr Glu Tyr
             185                 190                 195

 ttg gag gaa cga aga ata aag gag att gtg aag aaa cat tct cag ttt      679
 Leu Glu Glu Arg Arg Ile Lys Glu Ile Val Lys Lys His Ser Gln Phe
         200                 205                 210

 att gga tat ccc att act ctt ttt gtg gag aag gaa cgt gat aaa gaa      727
 Ile Gly Tyr Pro Ile Thr Leu Phe Val Glu Lys Glu Arg Asp Lys Glu
     215                 220                 225

 gta agc gat gat gag gct gaa gaa aag gaa gac aaa gaa gaa gaa aaa      775
 Val Ser Asp Asp Glu Ala Glu Glu Lys Glu Asp Lys Glu Glu Glu Lys
 230                 235                 240                 245

 aaa aaa gaa gag aaa gag tcg gaa gac aaa cct gaa att gaa gat gtt      823
 Lys Lys Glu Glu Lys Glu Ser Glu Asp Lys Pro Glu Ile Glu Asp Val
                 250                 255                 260

 ggt tct gat gag gaa gaa gaa aag aag gat ggt gac aag aag aag aag      871
 Gly Ser Asp Glu Glu Glu Glu Lys Lys Asp Gly Asp Lys Lys Lys Lys
             265                 270                 275

 aag aag att aag gaa aag tac atc gat caa gaa gag ctc aac aaa aca      919
 Lys Lys Ile Lys Glu Lys Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr
         280                 285                 290

 aag ccc atc tgg acc aga aat ccc gac gat att act aat gag gag tac      967
 Lys Pro Ile Trp Thr Arg Asn Pro Asp Asp Ile Thr Asn Glu Glu Tyr
     295                 300                 305

 gga gaa ttc tat aag agc ttg acc aat gac tgg gaa gat cac ttg gca     1015
 Gly Glu Phe Tyr Lys Ser Leu Thr Asn Asp Trp Glu Asp His Leu Ala
 310                 315                 320                 325

 gtg aag cat ttt tca gtt gaa gga cag ttg gaa ttc aga gcc ctt cta     1063
 Val Lys His Phe Ser Val Glu Gly Gln Leu Glu Phe Arg Ala Leu Leu
                 330                 335                 340

 ttt gtc cca cga cgt gct cct ttt gat ctg ttt gaa aac aga aag aaa     1111
 Phe Val Pro Arg Arg Ala Pro Phe Asp Leu Phe Glu Asn Arg Lys Lys
             345                 350                 355

 aag aac aat atc aaa ttg tat gta cgc aga gtt ttc atc atg gat aac     1159
 Lys Asn Asn Ile Lys Leu Tyr Val Arg Arg Val Phe Ile Met Asp Asn
         360                 365                 370

 tgt gag gag cta atc cct gaa tat ctg agt aag tat aga taggaaaaat      1208
 Cys Glu Glu Leu Ile Pro Glu Tyr Leu Ser Lys Tyr Arg 
     375                 380                 385

 aatcactgtc actgattaaa gaagtacttt ctgggtgggc atggtggctc acacctataa   1268

 tcctagcact ttgggaggcc ggggtgggca gatcacttga ggtcaggagt tcaagaccag   1328

 cctgggcaac atggtgaaac cccatttt                                      1356




      <210> 27
      <211> 1190
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(872)

      <400> 27
 acgttgcggt cttactcacg ttgcggcctt cctcgcgtcc ggccggg  atg aag ccg      56
                                                      Met Lys Pro
                                                        1

 atc cta ctg cag ggc cat gag cgg tcc att acg cag att aag tat aac      104
 Ile Leu Leu Gln Gly His Glu Arg Ser Ile Thr Gln Ile Lys Tyr Asn
       5                  10                  15

 cgc gaa gga gac ctc ctc ttt act gtg gcc aag gac cct atc gtc aat      152
 Arg Glu Gly Asp Leu Leu Phe Thr Val Ala Lys Asp Pro Ile Val Asn
  20                  25                  30                  35

 gta tgg tac tct gtg aat ggt gag agg ctg ggc acc tac atg ggc cat      200
 Val Trp Tyr Ser Val Asn Gly Glu Arg Leu Gly Thr Tyr Met Gly His
                  40                  45                  50

 acc gga gct gtg tgg tgt gtg gac gct gac tgg gac acc aag cat gtc      248
 Thr Gly Ala Val Trp Cys Val Asp Ala Asp Trp Asp Thr Lys His Val
              55                  60                  65

 ctc act ggc tca gct gac aac agc tgt cgt ctc tgg gac tgt gaa aca      296
 Leu Thr Gly Ser Ala Asp Asn Ser Cys Arg Leu Trp Asp Cys Glu Thr
          70                  75                  80

 gac aac aat gag ccc tac atg aag atc cct tgc aat gac tct aaa atc      344
 Asp Asn Asn Glu Pro Tyr Met Lys Ile Pro Cys Asn Asp Ser Lys Ile
      85                  90                  95

 acc agt gct gtt tgg gga ccc ctg ggg gag tgc atc atc gct ggc cat      392
 Thr Ser Ala Val Trp Gly Pro Leu Gly Glu Cys Ile Ile Ala Gly His
 100                 105                 110                 115

 gag agt gga gag ctc aac cag tat agt gcc aag tct gga gag gtg ttg      440
 Glu Ser Gly Glu Leu Asn Gln Tyr Ser Ala Lys Ser Gly Glu Val Leu
                 120                 125                 130

 gtg aat gtt aag gag cac tcc cgg cag atc aac gac atc cag tta tcc      488
 Val Asn Val Lys Glu His Ser Arg Gln Ile Asn Asp Ile Gln Leu Ser
             135                 140                 145

 agg gac atg acc atg ttt gtg acc gcg tcc aag gac aac aca gcc aag      536
 Arg Asp Met Thr Met Phe Val Thr Ala Ser Lys Asp Asn Thr Ala Lys
         150                 155                 160

 ctt ttt gac tcc aca act ctt gaa cat cag aag act ttc cgg aca gaa      584
 Leu Phe Asp Ser Thr Thr Leu Glu His Gln Lys Thr Phe Arg Thr Glu
     165                 170                 175

 cgt cct gtc aac tca gct gcc ctc tcc ccc aac tat gac cat gtg gtc      632
 Arg Pro Val Asn Ser Ala Ala Leu Ser Pro Asn Tyr Asp His Val Val
 180                 185                 190                 195

 ctg ggc ggt ggt cag gaa gcc atg gat gta acc aca acc tcc acc agg      680
 Leu Gly Gly Gly Gln Glu Ala Met Asp Val Thr Thr Thr Ser Thr Arg
                 200                 205                 210

 att ggc aag ttt gag gcc agg ttc ttc cat ttg gcc ttt gaa gaa gag      728
 Ile Gly Lys Phe Glu Ala Arg Phe Phe His Leu Ala Phe Glu Glu Glu
             215                 220                 225

 ttt gga aga gtc aag ggt cac ttt gga cct atc aac agt gtt gcc ttc      776
 Phe Gly Arg Val Lys Gly His Phe Gly Pro Ile Asn Ser Val Ala Phe
         230                 235                 240

 cat cct gat ggc aag agc tac agc agc ggc ggc gaa gat ggt tac gtc      824
 His Pro Asp Gly Lys Ser Tyr Ser Ser Gly Gly Glu Asp Gly Tyr Val
     245                 250                 255

 cgt atc cat tac ttc gac cca cag tac ttc gaa ttt gag ttt gag gct      872
 Arg Ile His Tyr Phe Asp Pro Gln Tyr Phe Glu Phe Glu Phe Glu Ala 
 260                 265                 270                 275

 taagaagctg gatctcctgc cgggcgtggt ggctcatgcc tgtaatccca ccactttttt    932

 tttaaggcag gcggatcacc tgaggtcagg agtttaagac cagcctgacc aacatggaga    992

 aacctcgtct ctactaaaaa tacaaaaata caaaaattag ccaggcatgg tggcacacgc   1052

 ctatagtccc agctactcag gaggctgagg caggagaatc acttgaaccc aggaggcaga   1112

 ggttgcagtg agctgagatc acgtcattgc actccatcct gagccacaag agcaaaactc   1172

 cgtctcaaaa aaaaaaaa                                                 1190




      <210> 28
      <211> 1304
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (36)..(1115)

      <220>
      <221> misc_feature
      <222> (1)...(1304)
      <223> n = a,t,c or g

      <400> 28
 gcccacgcgt ccgccttcct cgcgtcacag ccggg   atg aag ccg atc cta ctg      53
                                          Met Lys Pro Ile Leu Leu
                                            1               5

 cag ggc cat gag cgg tcc att acg cag att aag tat aac cgc gaa gga      101
 Gln Gly His Glu Arg Ser Ile Thr Gln Ile Lys Tyr Asn Arg Glu Gly
              10                  15                  20

 gac ctc ctc ttt act gtg gcc aag gac cct atc gtc aat gta tgg tac      149
 Asp Leu Leu Phe Thr Val Ala Lys Asp Pro Ile Val Asn Val Trp Tyr
          25                  30                  35

 tct gtg aat ggt gag agg ctg ggc acc tac atg ggc cat acc gga gct      197
 Ser Val Asn Gly Glu Arg Leu Gly Thr Tyr Met Gly His Thr Gly Ala
      40                  45                  50

 gtg tgg tgt gtg gac gct gac tgg gac acc aag cat gtc ctc act ggc      245
 Val Trp Cys Val Asp Ala Asp Trp Asp Thr Lys His Val Leu Thr Gly
  55                  60                  65                  70

 tca gct gac aac agc tgt cgt ctc tgg gac tgt gaa aca gga aag cag      293
 Ser Ala Asp Asn Ser Cys Arg Leu Trp Asp Cys Glu Thr Gly Lys Gln
                  75                  80                  85

 ctg gcc ctt ctc aag acc aat tcg gct gtc cgg acc tgc ggt ttt gac      341
 Leu Ala Leu Leu Lys Thr Asn Ser Ala Val Arg Thr Cys Gly Phe Asp
              90                  95                 100

 ttt ggg ggc aac atc atc atg ttc tcc acg gac aag cag atg ggc tac      389
 Phe Gly Gly Asn Ile Ile Met Phe Ser Thr Asp Lys Gln Met Gly Tyr
         105                 110                 115

 cag tgc ttt gtg agc ttt ttt gac ctg cgg gat ccg agc cag att gac      437
 Gln Cys Phe Val Ser Phe Phe Asp Leu Arg Asp Pro Ser Gln Ile Asp
     120                 125                 130

 aac aat gag ccc tac atg aag atc cct tgc aat gac tct aaa atc acc      485
 Asn Asn Glu Pro Tyr Met Lys Ile Pro Cys Asn Asp Ser Lys Ile Thr
 135                 140                 145                 150

 agt gct gtt tgg gga ccc ctg ggg gag tgc atc atc gct ggc cat gag      533
 Ser Ala Val Trp Gly Pro Leu Gly Glu Cys Ile Ile Ala Gly His Glu
                 155                 160                 165

 agt gga gag ctc aac cag tat agt gcc aag tct gga gag gtg ttg gtg      581
 Ser Gly Glu Leu Asn Gln Tyr Ser Ala Lys Ser Gly Glu Val Leu Val
             170                 175                 180

 aat gtt aag gag cac tcc cgg cag atc aac gac atc cag tta tcc agg      629
 Asn Val Lys Glu His Ser Arg Gln Ile Asn Asp Ile Gln Leu Ser Arg
         185                 190                 195

 gac atg acc atg ttt gtg acc gcg tcc aag gac aac aca gcc aag ctt      677
 Asp Met Thr Met Phe Val Thr Ala Ser Lys Asp Asn Thr Ala Lys Leu
     200                 205                 210

 ttt gac tcc aca act ctt gaa cat cag aag act ttc cgg aca gaa cgt      725
 Phe Asp Ser Thr Thr Leu Glu His Gln Lys Thr Phe Arg Thr Glu Arg
 215                 220                 225                 230

 cct gtc aac tca gct gcc ctc tcc ccc aac tat gac cat gtg gtc ctg      773
 Pro Val Asn Ser Ala Ala Leu Ser Pro Asn Tyr Asp His Val Val Leu
                 235                 240                 245

 ggc ggt ggt cag gaa gcc atg gat gta acc aca acc tcc acc agg att      821
 Gly Gly Gly Gln Glu Ala Met Asp Val Thr Thr Thr Ser Thr Arg Ile
             250                 255                 260

 ggc aag ttt gag gcc agg ttc ttc cat ttg gct ttg aag aag agt ttg      869
 Gly Lys Phe Glu Ala Arg Phe Phe His Leu Ala Leu Lys Lys Ser Leu
         265                 270                 275

 gaa gag tca agg gtc act ttg gac cta tca aca gtg ttg cct tcc atc      917
 Glu Glu Ser Arg Val Thr Leu Asp Leu Ser Thr Val Leu Pro Ser Ile
     280                 285                 290

 ctg atg gca aga gct aca gca gcg gcg gcg aag atg gtt acg tcc gta      965
 Leu Met Ala Arg Ala Thr Ala Ala Ala Ala Lys Met Val Thr Ser Val
 295                 300                 305                 310

 tcc att act tcg acc cac agt act tcg aat ttg agt ttg agg ctt aag     1013
 Ser Ile Thr Ser Thr His Ser Thr Ser Asn Leu Ser Leu Arg Leu Lys
                 315                 320                 325

 aag ctg gat ctc ctg ccg ggc gtg gtg gct cat gcc tgt aat ccc acc     1061
 Lys Leu Asp Leu Leu Pro Gly Val Val Ala His Ala Cys Asn Pro Thr
             330                 335                 340

 act ttt ttt ttt aag gca ggc gga tca cct gag gtc agg agt tta aga     1109
 Thr Phe Phe Phe Lys Ala Gly Gly Ser Pro Glu Val Arg Ser Leu Arg
         345                 350                 355

 cca gcc tgaccaacat gggagaaacc tcgtgttcta cttaaaaata caaaaaattt      1165
 Pro Ala 
     360

 aggccagggc atgggttggc acacgtctat agtcccagct acttgggaac tcgggaggct   1225

 gaggcgggag aatgacctga gcccgggagg cggagcttnc ggtgggcaga gattgcgcca   1285

 ttgcactcca gcctgggcg                                                1304




      <210> 29
      <211> 1568
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (70)..(1416)

      <400> 29
 tttcgtggag gagcgcgcgg gcacagggtg ccgctgaccg aggcgtgcaa agactccaga     60

 attggaggc    atg atg aag act ctg ctg ctg ttt gtg ggg ctg ctg ctg     108
              Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu
                1               5                  10

 acc tgg gag agt ggg cag gtc ctg ggg gac cag acg gtc tca gac aat      156
 Thr Trp Glu Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn
      15                  20                  25

 gag ctc cag gaa atg tcc aat cag gga agt aag tac gtc aat aag gaa      204
 Glu Leu Gln Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu
  30                  35                  40                  45

 att caa aat gct gtc aac ggg gtg aaa cag ata aag act ctc ata gaa      252
 Ile Gln Asn Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu
                  50                  55                  60

 aaa aca aac gaa gag cgc aag aca ctg ctc agc aac cta gaa gaa gcc      300
 Lys Thr Asn Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala
              65                  70                  75

 aag aag aaa aaa gag gat gcc cta aat gag acc agg gaa tca gag aca      348
 Lys Lys Lys Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr
          80                  85                  90

 aag ctg aag gag ctc cca gga gtg tgc aat gag acc atg atg gcc ctc      396
 Lys Leu Lys Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu
      95                 100                 105

 tgg gaa gag tgt aag ccc tgc ctg aaa cag acc tgc atg aag ttc tac      444
 Trp Glu Glu Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr
 110                 115                 120                 125

 gca cgc gtc tgc aga agt ggc tca ggc ctg gtt ggc cgc cag ctt gag      492
 Ala Arg Val Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu
                 130                 135                 140

 gag ttc ctg aac cag agc tcg ccc ttc tac ttc tgg atg aat ggt gac      540
 Glu Phe Leu Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp
             145                 150                 155

 cgc atc gac tcc ctg ctg gag aac gac cgg cag cag acg cac atg ctg      588
 Arg Ile Asp Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu
         160                 165                 170

 gat gtc atg cag gac cac ttc agc cgc gcg tcc agc atc ata gac gag      636
 Asp Val Met Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu
     175                 180                 185

 ctc ttc cag gac agg ttc ttc acc cgg gag ccc cag gat acc tac cac      684
 Leu Phe Gln Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His
 190                 195                 200                 205

 tac ctg ccc ttc agc ctg ccc cac cgg agg cct cac ttc ttc ttt ccc      732
 Tyr Leu Pro Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro
                 210                 215                 220

 aag tcc cgc atc gtc cgc agc ttg atg ccc ttc tct ccg tac gag ccc      780
 Lys Ser Arg Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro
             225                 230                 235

 ctg aac ttc cac gcc atg ttc cag ccc ttc ctt gag atg ata cac gag      828
 Leu Asn Phe His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu
         240                 245                 250

 gct cag cag gcc atg gac atc cac ttc cac agc ccg gcc ttc cag cac      876
 Ala Gln Gln Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His
     255                 260                 265

 ccg cca aca gaa ttc ata cga gaa ggc gac gat gac cgg act gtg tgc      924
 Pro Pro Thr Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys
 270                 275                 280                 285

 cgg gag atc cgc cac aac tcc acg ggc tgc ctg cgg atg aag gac cag      972
 Arg Glu Ile Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln
                 290                 295                 300

 tgt gac aag tgc cgg gag atc ttg tct gtg gac tgt tcc acc aac aac     1020
 Cys Asp Lys Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn
             305                 310                 315

 ccc tcc cag gct aag ctg cgg cgg gag ctc gac gaa tcc ctc cag gtc     1068
 Pro Ser Gln Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val
         320                 325                 330

 gct gag agg ttg acc agg aaa tac aac gag ctg cta aag tcc tac cag     1116
 Ala Glu Arg Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln
     335                 340                 345

 tgg aag atg ctc aac acc tcc tcc ttg ctg gag cag ctg aac gag cag     1164
 Trp Lys Met Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln
 350                 355                 360                 365

 ttt aac tgg gtg tcc cgg ctg gca aac ctc acg caa ggc gaa gac cag     1212
 Phe Asn Trp Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln
                 370                 375                 380

 tac tat ctg cgg gtc acc acg gtg gct tcc cac act tct gac tcg gac     1260
 Tyr Tyr Leu Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp
             385                 390                 395

 gtt cct tcc ggt gtc act gag gtg gtc gtg aag ctc ttt gac tct gat     1308
 Val Pro Ser Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp
         400                 405                 410

 ccc atc act gtg acg gtc cct gta gaa gtc tcc agg aag aac cct aaa     1356
 Pro Ile Thr Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys
     415                 420                 425

 ttt atg gag acc gtg gcg gag aaa gcg ctg cag gaa tac cgc aaa aag     1404
 Phe Met Glu Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys
 430                 435                 440                 445

 cac cgg gag gag tga gatgtggatg ttgcttttgc acctacgggg gcatctgagt     1459
 His Arg Glu Glu 


 ccagctcccc ccaagatgag ctgcagcccc ccagagagag ctctgcacgt caccaagtaa   1519

 ccaggccctg tattgcggcc gctctggggg ttctcccacg acgcaacac               1568




      <210> 30
      <211> 2277
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (32)..(1879)

      <400> 30
 ctggcgggac tgcgcggcgg caacagcaga c   atg tcg ggg gtc cgg ggc ctg      52
                                      Met Ser Gly Val Arg Gly Leu
                                        1               5

 tcg cgg ctg ctg agc gct cgg cgc ctg gcg ctg gcc aag gcg tgg cca      100
 Ser Arg Leu Leu Ser Ala Arg Arg Leu Ala Leu Ala Lys Ala Trp Pro
          10                  15                  20

 aca gtg ttg caa aca gga acc cga ggt ttt cac ttc act gtt gtt ggg      148
 Thr Val Leu Gln Thr Gly Thr Arg Gly Phe His Phe Thr Val Val Gly
      25                  30                  35

 aac aag agg gca tct gct aaa gtt tca gat tcc att tct gct cag tat      196
 Asn Lys Arg Ala Ser Ala Lys Val Ser Asp Ser Ile Ser Ala Gln Tyr
  40                  45                  50                  55

 cca gta gtg gat cat gaa ttt gat gca gtg gtg gta ggc gct gga ggg      244
 Pro Val Val Asp His Glu Phe Asp Ala Val Val Val Gly Ala Gly Gly
                  60                  65                  70

 gca ggc ttg cga gct gca ttt ggc ctt tct gag gca ggg ttt aat aca      292
 Ala Gly Leu Arg Ala Ala Phe Gly Leu Ser Glu Ala Gly Phe Asn Thr
              75                  80                  85

 gca tgt gtt acc aag ctg ttt cct acc agg tca cac act gtt gca gca      340
 Ala Cys Val Thr Lys Leu Phe Pro Thr Arg Ser His Thr Val Ala Ala
          90                  95                 100

 cag cta gaa aat tat ggc atg ccg ttt agc aga act gaa gat ggg aag      388
 Gln Leu Glu Asn Tyr Gly Met Pro Phe Ser Arg Thr Glu Asp Gly Lys
     105                 110                 115

 att tat cag cgt gca ttt ggt gga cag agc ctc aag ttt gga aag ggc      436
 Ile Tyr Gln Arg Ala Phe Gly Gly Gln Ser Leu Lys Phe Gly Lys Gly
 120                 125                 130                 135

 ggg cag gcc cat cgg tgc tgc tgt gtg gct gat cgg act ggc cac tcg      484
 Gly Gln Ala His Arg Cys Cys Cys Val Ala Asp Arg Thr Gly His Ser
                 140                 145                 150

 cta ttg cac acc tta tat gga cgg tct ctg cga tat gat acc agc tat      532
 Leu Leu His Thr Leu Tyr Gly Arg Ser Leu Arg Tyr Asp Thr Ser Tyr
             155                 160                 165

 ttt gtg gag tat ttt gcc ttg gat ctc ctg atg gag aac ggg gag tgc      580
 Phe Val Glu Tyr Phe Ala Leu Asp Leu Leu Met Glu Asn Gly Glu Cys
         170                 175                 180

 cgt ggt gtc atc gca ctg tgc ata gag gac ggg tcc atc cat cgc ata      628
 Arg Gly Val Ile Ala Leu Cys Ile Glu Asp Gly Ser Ile His Arg Ile
     185                 190                 195

 aga gca aag aac act gtt gtt gcc aca gga ggc tac ggg cgc acc tac      676
 Arg Ala Lys Asn Thr Val Val Ala Thr Gly Gly Tyr Gly Arg Thr Tyr
 200                 205                 210                 215

 ttc agc tgc acg tct gcc cac acc agc act ggc gac ggc acg gcc atg      724
 Phe Ser Cys Thr Ser Ala His Thr Ser Thr Gly Asp Gly Thr Ala Met
                 220                 225                 230

 atc acc agg gca ggc ctt cct tgc cag gac cta gag ttt gtt cag ttc      772
 Ile Thr Arg Ala Gly Leu Pro Cys Gln Asp Leu Glu Phe Val Gln Phe
             235                 240                 245

 cac ccc aca ggc ata tat ggt gct ggt tgt ctc att acg gaa gga tgt      820
 His Pro Thr Gly Ile Tyr Gly Ala Gly Cys Leu Ile Thr Glu Gly Cys
         250                 255                 260

 cgt gga gag gga ggc att ctc att aac agt caa ggc gaa agg ttt atg      868
 Arg Gly Glu Gly Gly Ile Leu Ile Asn Ser Gln Gly Glu Arg Phe Met
     265                 270                 275

 gag cga tac gcc cct gtc gcg aag gac ctg gcg tct aga gat gtg gtg      916
 Glu Arg Tyr Ala Pro Val Ala Lys Asp Leu Ala Ser Arg Asp Val Val
 280                 285                 290                 295

 tct cgg tcc atg act ctg gag atc cga gaa gga aga ggc tgt ggc cct      964
 Ser Arg Ser Met Thr Leu Glu Ile Arg Glu Gly Arg Gly Cys Gly Pro
                 300                 305                 310

 gag aaa gat cac gtc tac ctg cag ctg cac cac cta cct cca gag cag     1012
 Glu Lys Asp His Val Tyr Leu Gln Leu His His Leu Pro Pro Glu Gln
             315                 320                 325

 ctg gcc acg cgc ctg cct ggc att tca gag aca gcc atg atc ttc gct     1060
 Leu Ala Thr Arg Leu Pro Gly Ile Ser Glu Thr Ala Met Ile Phe Ala
         330                 335                 340

 ggc gtg gac gtc acg aag gag ccg atc cct gtc ctc ccc acc gtg cat     1108
 Gly Val Asp Val Thr Lys Glu Pro Ile Pro Val Leu Pro Thr Val His
     345                 350                 355

 tat aac atg ggc ggc att ccc acc aac tac aag ggg cag gtc ctg agg     1156
 Tyr Asn Met Gly Gly Ile Pro Thr Asn Tyr Lys Gly Gln Val Leu Arg
 360                 365                 370                 375

 cac gtg aat ggc cag gat cag att gtg ccc ggc ctg tac gcc tgt ggg     1204
 His Val Asn Gly Gln Asp Gln Ile Val Pro Gly Leu Tyr Ala Cys Gly
                 380                 385                 390

 gag gcc gcc tgt gcc tcg gta cat ggt gcc aac cgc ctc ggg gca aac     1252
 Glu Ala Ala Cys Ala Ser Val His Gly Ala Asn Arg Leu Gly Ala Asn
             395                 400                 405

 tcg ctc ttg gac ctg gtt gtc ttt ggt cgg gca tgt gcc ctg agc atc     1300
 Ser Leu Leu Asp Leu Val Val Phe Gly Arg Ala Cys Ala Leu Ser Ile
         410                 415                 420

 gaa gag tca tgc agg cct gga gat aaa gtc cct cca att aaa cca aac     1348
 Glu Glu Ser Cys Arg Pro Gly Asp Lys Val Pro Pro Ile Lys Pro Asn
     425                 430                 435

 gct ggg gaa gaa tct gtc atg aat ctt gac aaa ttg aga ttt gct gat     1396
 Ala Gly Glu Glu Ser Val Met Asn Leu Asp Lys Leu Arg Phe Ala Asp
 440                 445                 450                 455

 gga agc ata aga aca tcg gaa ctg cga ctc agc atg cag aag tca atg     1444
 Gly Ser Ile Arg Thr Ser Glu Leu Arg Leu Ser Met Gln Lys Ser Met
                 460                 465                 470

 caa aat cat gct gcc gtg ttc cgt gtg gga agc gtg ttg caa gaa ggt     1492
 Gln Asn His Ala Ala Val Phe Arg Val Gly Ser Val Leu Gln Glu Gly
             475                 480                 485

 tgt ggg aaa atc agc aag ctc tat gga gac cta aag cac ctg aag acg     1540
 Cys Gly Lys Ile Ser Lys Leu Tyr Gly Asp Leu Lys His Leu Lys Thr
         490                 495                 500

 ttc gac cgg gga atg gtc tgg aac acg gac ctg gtg gag acc ctg gag     1588
 Phe Asp Arg Gly Met Val Trp Asn Thr Asp Leu Val Glu Thr Leu Glu
     505                 510                 515

 ctg cag aac ctg atg ctg tgt gcg ctg cag acc atc tac gga gca gag     1636
 Leu Gln Asn Leu Met Leu Cys Ala Leu Gln Thr Ile Tyr Gly Ala Glu
 520                 525                 530                 535

 gca cgg aag gag tca cgg ggc gcg cat gcc agg gaa gac tac aag gtg     1684
 Ala Arg Lys Glu Ser Arg Gly Ala His Ala Arg Glu Asp Tyr Lys Val
                 540                 545                 550

 cgg att gat gag tac gat tac tcc aag ccc atc cag ggg caa cag aag     1732
 Arg Ile Asp Glu Tyr Asp Tyr Ser Lys Pro Ile Gln Gly Gln Gln Lys
             555                 560                 565

 aag ccc ttt gag gag cac tgg agg aag cac acc ctg tcc tat gtg gac     1780
 Lys Pro Phe Glu Glu His Trp Arg Lys His Thr Leu Ser Tyr Val Asp
         570                 575                 580

 gtt ggc act ggg aag gtc act ctg gaa tat aga ccc gtg atc gac aaa     1828
 Val Gly Thr Gly Lys Val Thr Leu Glu Tyr Arg Pro Val Ile Asp Lys
     585                 590                 595

 act ttg aac gag gct gac tgt gcc acc gtc ccg cca gcc att cgc tcc     1876
 Thr Leu Asn Glu Ala Asp Cys Ala Thr Val Pro Pro Ala Ile Arg Ser
 600                 605                 610                 615

 tac tgat gagacaagat gtggtgatga cagaatcagc ttttgtaatt atgtataata     1933
 Tyr 


 gctcatgcat gtgtccatgt cataactgtc ttcatacgct tctgcactct ggggaagaag   1993

 gagtacattg aagggagatt ggcacctagt ggctgggagc ttgccaggaa cccagtggcc   2053

 agggagcgtg gcacttacct ttgtcccttg cttcattctt gtgagatgat aaaactgggc   2113

 acagctctta aataaaatat aaatgaacaa actttctttt atttccaaat ccatttgaaa   2173

 tattttactg ttgtgacttt agtcatattt gttgacctaa aaatcaaatg taatctttgt   2233

 attgtgttac atcaaaatcc agatattttg tatagtttct tttt                    2277




      <210> 31
      <211> 2247
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (158)..(604)

      <400> 31
 aaggatcctt aattaaatta atcccccccc cccccgggcg cgcgctgcgg gcagtgagtg     60

 tggaggcgcg gacgcgcggc ggagctggaa ctgctgcagc tgctgccgcc gccggaggaa    120

 ccttgatccc cgtgctccgg acaccccggg cctcgcc atg gct gac cag ctg act     175
                                          Met Ala Asp Gln Leu Thr
                                            1               5

 gag gag cag att gca gag ttc aag gag gcc ttc tcc ctc ttt gac aag      223
 Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala Phe Ser Leu Phe Asp Lys
              10                  15                  20

 gat gga gat ggc act atc acc acc aag gag ttg ggg aca gtg atg aga      271
 Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu Leu Gly Thr Val Met Arg
          25                  30                  35

 tcc ctg gga cag aac ccc act gaa gca gag ctg cag gat atg atc aat      319
 Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu Leu Gln Asp Met Ile Asn
      40                  45                  50

 gag gtg gat gca gat ggg aac ggg acc att gac ttc ccg gag ttc ctg      367
 Glu Val Asp Ala Asp Gly Asn Gly Thr Ile Asp Phe Pro Glu Phe Leu
  55                  60                  65                  70

 acc atg atg gcc aga aag atg aag gac aca gac agt gag gag gag atc      415
 Thr Met Met Ala Arg Lys Met Lys Asp Thr Asp Ser Glu Glu Glu Ile
                  75                  80                  85

 cga gag gcg ttc cgt gtc ttt gac aag gat ggg aat ggc tac atc agc      463
 Arg Glu Ala Phe Arg Val Phe Asp Lys Asp Gly Asn Gly Tyr Ile Ser
              90                  95                 100

 gcc gca gag ctg cgt cac gta atg acg aac ctg ggg gag aag ctg acc      511
 Ala Ala Glu Leu Arg His Val Met Thr Asn Leu Gly Glu Lys Leu Thr
         105                 110                 115

 gat gag gag gtg gat gag atg atc agg gag gct gac atc gat gga gat      559
 Asp Glu Glu Val Asp Glu Met Ile Arg Glu Ala Asp Ile Asp Gly Asp
     120                 125                 130

 ggc cag gtc aat tat gaa gag ttt gta cag atg atg act gca aag tga      607
 Gly Gln Val Asn Tyr Glu Glu Phe Val Gln Met Met Thr Ala Lys 
 135                 140                 145

 aggccccccg ggcagctggc gatgcccgtt ctcttgatct ctctcttctc gcgcgcgcac    667

 tctctcttca acactcccct gcgtaccccg gttctagcaa acaccaattg attgactgag    727

 aatctgataa agcaacaaaa gatttgtccc aagctgcatg attgctcttt ctccttcttc    787

 cctgagtctc tctccatgcc cctcatctct tccttttgcc ctcgcctctt ccatccatgt    847

 cttccaaggc ctgatgcatt cataagttga agccctcccc agatcccctt ggggagcctc    907

 tgccctcctc cagcccggat ggctctcctc cattttggtt tgtttcctct tgtttgtcat    967

 cttattttgg gtgctggggt ggctgccagc cctgtcccgg gacctgctgg gagggacaag   1027

 aggccctccc ccaggcagaa gagcatgccc tttgccgttg catgcaacca gccctgtgat   1087

 tccacgtgca gatcccagca gcctgttggg gcaggggtgc caagagaggc attccagaag   1147

 gactgagggg gcgttgagga attgtggcgt tgactggatg tggcccagga gggggtcgag   1207

 ggggccaact cacagaaggg gactgacagt gggcaacact cacatcccac tggctgctgt   1267

 tctgaaacca tctgattggc tttctgaggt ttggctgggt ggggactgct catttggcca   1327

 ctctgcagat tggacttgcc cgcgttcctg aagcgctctc gagctgttct gtaaatacct   1387

 ggtgctaaca tcccatgccg ctccctcctc acgatgcacc caccgccctg agggcccgtc   1447

 ctaggaatgg atgtggggat ggtcgctttg taatgtgctg gttctctttt tttttctttc   1507

 ccctctatgg cccttaagac tttcattttg ttcagaacca tgctgggcta gctaaagggt   1567

 ggggagaggg aagatgggcc ccaccacgct ctcaagagaa cgcacctgca ataaaacagt   1627

 cttgtcggcc agctgcccag gggacggcag ctacagcagc ctctgcgtcc tggtccgcca   1687

 gcacctcccg cttctccgtg gtgacttggc gccgcttcct cacatctgtg ctccgtgccc   1747

 tcttccctgc ctcttccctc gcccacctgc ctgcccccat actcccccag cggagagcat   1807

 gatccgtgcc cttgcttctg actttcgcct ctgggacaag taagtcaatg tgggcagttc   1867

 agtcgtctgg gttttttccc cttttctgtt catttcatct ggctcccccc accacctccc   1927

 caccccaccc cccaccccct gcttcccctc actgcccagg tcgatcaagt ggcttttcct   1987

 gggacctgcc cagctttgag aatctcttct catccaccct ctggcaccca gcctctgagg   2047

 gaaggaggga tggggcatag tgggagaccc agccaagagc tgagggtaag ggcaggtagg   2107

 cgtgaggctg tggacatttt cggaatgttt tggttttgtt ttttttaaac cgggcaatat   2167

 tgtgttcagt tcaagctgtg aagaaaaata tatatcaatg ttttccaata aaatacagtg   2227

 actacctgaa aaaaaaaaaa                                               2247




      <210> 32
      <211> 1508
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (87)..(1175)

      <400> 32
 aagaaggaag aagagggtag aggaggagag ggaggaggag gagggaggtg gcggcgccgt     60

 ggcggaggag caggagcagg aggggg atg gag agg aga agg ctc ctg ggt ggc     113
                              Met Glu Arg Arg Arg Leu Leu Gly Gly
                                1               5

 atg gcg ctc ctg ctc ctc cag gcg ctg ccc agc ccc ttg tca gcc agg      161
 Met Ala Leu Leu Leu Leu Gln Ala Leu Pro Ser Pro Leu Ser Ala Arg
  10                  15                  20                  25

 gct gaa ccc ccg cag gat aag gaa gcc tgt gtg ggt acc aac aat caa      209
 Ala Glu Pro Pro Gln Asp Lys Glu Ala Cys Val Gly Thr Asn Asn Gln
                  30                  35                  40

 agc tac atc tgt gac aca gga cac tgc tgt gga cag tct cag tgc tgc      257
 Ser Tyr Ile Cys Asp Thr Gly His Cys Cys Gly Gln Ser Gln Cys Cys
              45                  50                  55

 aac tac tac tat gaa ctc tgg tgg ttc tgg ctg gtg tgg acc atc atc      305
 Asn Tyr Tyr Tyr Glu Leu Trp Trp Phe Trp Leu Val Trp Thr Ile Ile
          60                  65                  70

 atc atc ctg agc tgc tgc tgt gtt tgc cac cac cgc cga gcc aag cac      353
 Ile Ile Leu Ser Cys Cys Cys Val Cys His His Arg Arg Ala Lys His
      75                  80                  85

 cgc ctt cag gcc cag cag cgg caa cat gaa atc aac ctg atc gct tac      401
 Arg Leu Gln Ala Gln Gln Arg Gln His Glu Ile Asn Leu Ile Ala Tyr
  90                  95                 100                 105

 cga gaa gcc cac aat tac tca gcg ctg cca ttt tat ttc agg ttt ttg      449
 Arg Glu Ala His Asn Tyr Ser Ala Leu Pro Phe Tyr Phe Arg Phe Leu
                 110                 115                 120

 cca aac tat tta cta cct cct tat gag gaa gtg gtg aac cga cct cca      497
 Pro Asn Tyr Leu Leu Pro Pro Tyr Glu Glu Val Val Asn Arg Pro Pro
             125                 130                 135

 act cct ccc cca cca tac agt gcc ttc cag cta cag cag cag cag ctg      545
 Thr Pro Pro Pro Pro Tyr Ser Ala Phe Gln Leu Gln Gln Gln Gln Leu
         140                 145                 150

 ctg cct cca cag tgt ggc cct gca ggt ggc agt ccc ccg ggc atc gat      593
 Leu Pro Pro Gln Cys Gly Pro Ala Gly Gly Ser Pro Pro Gly Ile Asp
     155                 160                 165

 ccc acc agg gga tcc cag ggg gca cag agc agc ccc ttg tct gag ccc      641
 Pro Thr Arg Gly Ser Gln Gly Ala Gln Ser Ser Pro Leu Ser Glu Pro
 170                 175                 180                 185

 agc aga agc agc aca aga ccc cca agc atc gct gac cct gat ccc tct      689
 Ser Arg Ser Ser Thr Arg Pro Pro Ser Ile Ala Asp Pro Asp Pro Ser
                 190                 195                 200

 gac cta cca gtt gac cga gca gcc acc aaa gcc cca ggg atg gag ccc      737
 Asp Leu Pro Val Asp Arg Ala Ala Thr Lys Ala Pro Gly Met Glu Pro
             205                 210                 215

 agt ggc tct gtg gct ggc ctg ggg gag ctg gac ccg ggg gcc ttc ctg      785
 Ser Gly Ser Val Ala Gly Leu Gly Glu Leu Asp Pro Gly Ala Phe Leu
         220                 225                 230

 gac aaa gat gca gaa tgt agg gag gag ctg ctg aaa gat gac agc tct      833
 Asp Lys Asp Ala Glu Cys Arg Glu Glu Leu Leu Lys Asp Asp Ser Ser
     235                 240                 245

 gaa cac ggc gca ccc gac agc aaa gag aag acg cct ggg aga cat cgc      881
 Glu His Gly Ala Pro Asp Ser Lys Glu Lys Thr Pro Gly Arg His Arg
 250                 255                 260                 265

 cgc ttc aca ggt gac tcg ggc att gaa gtg tgt gtg tgc aac cgg ggc      929
 Arg Phe Thr Gly Asp Ser Gly Ile Glu Val Cys Val Cys Asn Arg Gly
                 270                 275                 280

 cac cat gac gat gac ctc aaa gag ttc aac aca ctc atc gat gat gct      977
 His His Asp Asp Asp Leu Lys Glu Phe Asn Thr Leu Ile Asp Asp Ala
             285                 290                 295

 ctg gat ggg ccc ctg gac ttc tgc gac agc tgc cat gtg cgg ccc cct     1025
 Leu Asp Gly Pro Leu Asp Phe Cys Asp Ser Cys His Val Arg Pro Pro
         300                 305                 310

 ggt gat gag gag gaa ggc ctc tgt cag ccc tct gag gag cag gct cga     1073
 Gly Asp Glu Glu Glu Gly Leu Cys Gln Pro Ser Glu Glu Gln Ala Arg
     315                 320                 325

 gag cct ggg cac ccg cac ctg cca cgg ccg ccc gca tgc ctg ctg ctg     1121
 Glu Pro Gly His Pro His Leu Pro Arg Pro Pro Ala Cys Leu Leu Leu
 330                 335                 340                 345

 aac acc atc aac gag cag gac tct ccc aac tcc cag agc agc agc tcc     1169
 Asn Thr Ile Asn Glu Gln Asp Ser Pro Asn Ser Gln Ser Ser Ser Ser
                 350                 355                 360

 ccc agc tagagcaggt cctgccagca cccagcaact tggcaaagca accagggtag      1225
 Pro Ser 


 gggagaacca cgagagaagc attaagtgac tttcaaagac tttcagagta cagccacttg   1285

 gttccttttt gtttgttttc cttctcctct cctgcatttt cctccatctc caggtacagt   1345

 tcggggtgtg gatgcctctt cctccacaag ggcacagtgt tgtggagggc taagttggtt   1405

 ctgtgactca ttcctcatac cctaactcca tctcctttct ttaaagtcaa atctcaccta   1465

 cctgtttggg tcagagagat gtgttttaaa agcccccaag gaa                     1508




      <210> 33
      <211> 1481
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (26)..(1126)

      <400> 33
 ttcctgcctc tgattccggg ctgtc  atg gcg acc ccc aac aat ctg acc ccc      52
                              Met Ala Thr Pro Asn Asn Leu Thr Pro
                                1               5

 acc aac tgc agc tgg tgg ccc atc tcc gcg ctg gag agc gat gcg gcc      100
 Thr Asn Cys Ser Trp Trp Pro Ile Ser Ala Leu Glu Ser Asp Ala Ala
  10                  15                  20                  25

 aag cca gcg gag gcc ccc gac gct ccc gag gcg gcc agc ccc gcc cat      148
 Lys Pro Ala Glu Ala Pro Asp Ala Pro Glu Ala Ala Ser Pro Ala His
                  30                  35                  40

 tgg ccc agg gag agc ctg gtt ctg tac cac tgg acc cag tcc ttc agc      196
 Trp Pro Arg Glu Ser Leu Val Leu Tyr His Trp Thr Gln Ser Phe Ser
              45                  50                  55

 tcg cag aag gtg cgg ctg gtg atc gcc gag aag ggc ctg gtg tgc gag      244
 Ser Gln Lys Val Arg Leu Val Ile Ala Glu Lys Gly Leu Val Cys Glu
          60                  65                  70

 gag cgg gac gtg agc ctg cca cag agc gag cac aag gag ccc tgg ttc      292
 Glu Arg Asp Val Ser Leu Pro Gln Ser Glu His Lys Glu Pro Trp Phe
      75                  80                  85

 atg cgg ctc aac ctg ggc gag gag gtg ccc gtc atc atc cac cgc gac      340
 Met Arg Leu Asn Leu Gly Glu Glu Val Pro Val Ile Ile His Arg Asp
  90                  95                 100                 105

 aac atc atc agt gac tat gac cag atc att gac tat gtg gag cgc acc      388
 Asn Ile Ile Ser Asp Tyr Asp Gln Ile Ile Asp Tyr Val Glu Arg Thr
                 110                 115                 120

 ttc aca gga gag cac gtg gtg gcc ctg atg ccc gag gtg ggc agc ctg      436
 Phe Thr Gly Glu His Val Val Ala Leu Met Pro Glu Val Gly Ser Leu
             125                 130                 135

 cag cac gca cgg gtg ctg cag tac cgg gag ctg ctg gac gca ctg ccc      484
 Gln His Ala Arg Val Leu Gln Tyr Arg Glu Leu Leu Asp Ala Leu Pro
         140                 145                 150

 atg gat gcc tac acg cat ggc tgc atc ctg cat ccc gag ctc acc acc      532
 Met Asp Ala Tyr Thr His Gly Cys Ile Leu His Pro Glu Leu Thr Thr
     155                 160                 165

 gac tcc atg atc ccc aag tac gcc acg gcc gag atc cgc aga cat tta      580
 Asp Ser Met Ile Pro Lys Tyr Ala Thr Ala Glu Ile Arg Arg His Leu
 170                 175                 180                 185

 gcc aat gcc acc acg gac ctc atg aaa ctg gac cat gaa gag gag ccc      628
 Ala Asn Ala Thr Thr Asp Leu Met Lys Leu Asp His Glu Glu Glu Pro
                 190                 195                 200

 cag ctc tcc gag ccc tac ctt tct aaa caa aag aag ctc atg gcc aag      676
 Gln Leu Ser Glu Pro Tyr Leu Ser Lys Gln Lys Lys Leu Met Ala Lys
             205                 210                 215

 atc ttg gag cat gat gat gtg agc tac ctg aag aag atc ctc ggg gaa      724
 Ile Leu Glu His Asp Asp Val Ser Tyr Leu Lys Lys Ile Leu Gly Glu
         220                 225                 230

 ctg gcc atg gtg ctg gac cag att gag gcg gag ctg gag aag agg aag      772
 Leu Ala Met Val Leu Asp Gln Ile Glu Ala Glu Leu Glu Lys Arg Lys
     235                 240                 245

 ctg gag aac gag ggg cag aaa tgc gag ctg tgg ctc tgt ggc tgt gcc      820
 Leu Glu Asn Glu Gly Gln Lys Cys Glu Leu Trp Leu Cys Gly Cys Ala
 250                 255                 260                 265

 ttc acc ctc gct gat gtc ctc ctg gga gcc acc ctg cac cgc ctc aag      868
 Phe Thr Leu Ala Asp Val Leu Leu Gly Ala Thr Leu His Arg Leu Lys
                 270                 275                 280

 ttc ctg gga ctg tcc aag aaa tac tgg gaa gat ggc agc cgg ccc aac      916
 Phe Leu Gly Leu Ser Lys Lys Tyr Trp Glu Asp Gly Ser Arg Pro Asn
             285                 290                 295

 ctg cag tcc ttc ttt gag agg gtc cag aga cgc ttt gcc ttc cgg aaa      964
 Leu Gln Ser Phe Phe Glu Arg Val Gln Arg Arg Phe Ala Phe Arg Lys
         300                 305                 310

 gtc ctg ggt gac atc cac acc acc ctg ctg tcg gcc gtc atc ccc aat     1012
 Val Leu Gly Asp Ile His Thr Thr Leu Leu Ser Ala Val Ile Pro Asn
     315                 320                 325

 gct ttc cgg ctg gtc aag agg aaa ccc cca tcc ttc ttc ggg gcg tcc     1060
 Ala Phe Arg Leu Val Lys Arg Lys Pro Pro Ser Phe Phe Gly Ala Ser
 330                 335                 340                 345

 ttc ctc atg ggc tcc ctg ggt ggg atg ggc tac ttt gcc tac tgg tac     1108
 Phe Leu Met Gly Ser Leu Gly Gly Met Gly Tyr Phe Ala Tyr Trp Tyr
                 350                 355                 360

 ctc aag aaa aaa tac atc tagggc caggcctggg gcttggtgtc tgactgtcgg     1162
 Leu Lys Lys Lys Tyr Ile 
             365

 tgtctctgtg ctgtgtgatt ccccgtgagc tctcagtaac tcactgtctc atgaacactt   1222

 ggacagccct ccccgccctt cgttctgagt aataataccg tcagtgtgaa aacattccgt   1282

 agtttagaag tagacgttgc caatgctgtg actcaaggcc acggctctgc taaaagagag   1342

 agaggaagcg agagagagag agaaaaaaca aaaaacagaa aacacgaatg ccttttctat   1402

 cgattcaagg tctcaagatg gaacttgtgg agactggtta ggatctgagg gaactcttcc   1462

 acaggacaaa gccgacatc                                                1481




      <210> 34
      <211> 9098
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (75)..(9095)

      <400> 34
 gcacgagggt aggcttctgg gagcgaccgc tccgctcgtc tcgttggttc cggaggtcgc     60

 tgcggcggtg ggaa  atg ctg gcg cgc gcg gcg cgg ggc act ggg gcc ctt     110
                  Met Leu Ala Arg Ala Ala Arg Gly Thr Gly Ala Leu
                    1               5                  10

 ttg ctg agg ggc tct cta ctg gct tct ggc cgc gct ccg cgc cgc gcc      158
 Leu Leu Arg Gly Ser Leu Leu Ala Ser Gly Arg Ala Pro Arg Arg Ala
          15                  20                  25

 tcc tct gga ttg ccc cga aac acc gtg gta ctg ttc gtg ccg cag cag      206
 Ser Ser Gly Leu Pro Arg Asn Thr Val Val Leu Phe Val Pro Gln Gln
      30                  35                  40

 gag gcc tgg gtg gtg gag cga atg ggc cga ttc cac cgg atc ctg gag      254
 Glu Ala Trp Val Val Glu Arg Met Gly Arg Phe His Arg Ile Leu Glu
  45                  50                  55                  60

 cct ggt ttg aac atc ctc atc cct gtg tta gac cgg atc cga tat gtg      302
 Pro Gly Leu Asn Ile Leu Ile Pro Val Leu Asp Arg Ile Arg Tyr Val
                  65                  70                  75

 cag agt ctc aag gaa att gtc atc aac gtg cct gag cag tcg gct gtg      350
 Gln Ser Leu Lys Glu Ile Val Ile Asn Val Pro Glu Gln Ser Ala Val
              80                  85                  90

 act ctc gac aat gta act ctg caa atc gat gga gtc ctt tac ctg cgc      398
 Thr Leu Asp Asn Val Thr Leu Gln Ile Asp Gly Val Leu Tyr Leu Arg
          95                 100                 105

 atc atg gac cct tac aag gca agc tac ggt gtg gag gac cct gag tat      446
 Ile Met Asp Pro Tyr Lys Ala Ser Tyr Gly Val Glu Asp Pro Glu Tyr
     110                 115                 120

 gcc gtc acc cag cta gct caa aca acc atg aga tca gag ctc ggc aaa      494
 Ala Val Thr Gln Leu Ala Gln Thr Thr Met Arg Ser Glu Leu Gly Lys
 125                 130                 135                 140

 ctc tct ctg gac aaa gtc ttc cgg gaa cgg gag tcc ctg aat gcc agc      542
 Leu Ser Leu Asp Lys Val Phe Arg Glu Arg Glu Ser Leu Asn Ala Ser
                 145                 150                 155

 att gtg gat gcc atc aac caa gct gct gac tgc tgg ggt atc cgc tgc      590
 Ile Val Asp Ala Ile Asn Gln Ala Ala Asp Cys Trp Gly Ile Arg Cys
             160                 165                 170

 ctc cgt tat gag atc aag gat atc cat gtg cca ccc cgg gtg aaa gag      638
 Leu Arg Tyr Glu Ile Lys Asp Ile His Val Pro Pro Arg Val Lys Glu
         175                 180                 185

 tct atg cag atg cag gtg gag gca gag cgg cgg aaa cgg gcc aca gtt      686
 Ser Met Gln Met Gln Val Glu Ala Glu Arg Arg Lys Arg Ala Thr Val
     190                 195                 200

 cta gag tct gag ggg acc cga gag tcg gcc atc aat gtg gca gaa ggg      734
 Leu Glu Ser Glu Gly Thr Arg Glu Ser Ala Ile Asn Val Ala Glu Gly
 205                 210                 215                 220

 aag aaa cag gcc cag atc ctg gcc tcc gaa gca gaa aag gct gaa cag      782
 Lys Lys Gln Ala Gln Ile Leu Ala Ser Glu Ala Glu Lys Ala Glu Gln
                 225                 230                 235

 ata aat cag gca gca gga gag gcc agt gca gtt ctg gcg aag gcc aag      830
 Ile Asn Gln Ala Ala Gly Glu Ala Ser Ala Val Leu Ala Lys Ala Lys
             240                 245                 250

 gct aaa gct gaa gct att cga atc ctg gct gca gct ctg aca caa cat      878
 Ala Lys Ala Glu Ala Ile Arg Ile Leu Ala Ala Ala Leu Thr Gln His
         255                 260                 265

 aat gga gat gca gca gct tca ctg act gtg gcc gag cag tat gtc agc      926
 Asn Gly Asp Ala Ala Ala Ser Leu Thr Val Ala Glu Gln Tyr Val Ser
     270                 275                 280

 gcg ttc tcc aaa ctg gcc aag gac tcc aac act atc cta ctg ccc tcc      974
 Ala Phe Ser Lys Leu Ala Lys Asp Ser Asn Thr Ile Leu Leu Pro Ser
 285                 290                 295                 300

 aac cct ggc gat gtc acc agc atg gtg gct cag gcc atg ggt gta tat     1022
 Asn Pro Gly Asp Val Thr Ser Met Val Ala Gln Ala Met Gly Val Tyr
                 305                 310                 315

 gga gcc ctc acc aaa gcc cca gtg cca ggg act cca gac tca ctc tcc     1070
 Gly Ala Leu Thr Lys Ala Pro Val Pro Gly Thr Pro Asp Ser Leu Ser
             320                 325                 330

 agt ggg agc agc aga gat gtc cag ggt aca gat gca agt ctt gat gag     1118
 Ser Gly Ser Ser Arg Asp Val Gln Gly Thr Asp Ala Ser Leu Asp Glu
         335                 340                 345

 gaa ctt gat cga gtc aag atg act tgg tcc cct gtc ccc aat ttt caa     1166
 Glu Leu Asp Arg Val Lys Met Thr Trp Ser Pro Val Pro Asn Phe Gln
     350                 355                 360

 tta cta aat atc cca tca aac tgg ggc cag ccc cac gct cct ggc caa     1214
 Leu Leu Asn Ile Pro Ser Asn Trp Gly Gln Pro His Ala Pro Gly Gln
 365                 370                 375                 380

 act tcc acc gag gtg ccg gca gat ggc gat gga gcc acc gac ggg cca     1262
 Thr Ser Thr Glu Val Pro Ala Asp Gly Asp Gly Ala Thr Asp Gly Pro
                 385                 390                 395

 ctc tgt ctg gcg cac gca tct ctg tgc tgc cag gtc gca ggc gcc gcc     1310
 Leu Cys Leu Ala His Ala Ser Leu Cys Cys Gln Val Ala Gly Ala Ala
             400                 405                 410

 gcc gcc gca ctt ccg ggt gcc att gca ggc ggc gcc gtc ggc tgg gcc     1358
 Ala Ala Ala Leu Pro Gly Ala Ile Ala Gly Gly Ala Val Gly Trp Ala
         415                 420                 425

 cgg att ccc ctg cgg ctt cga tcc ctt tcc act ggg atg cag aaa gcc     1406
 Arg Ile Pro Leu Arg Leu Arg Ser Leu Ser Thr Gly Met Gln Lys Ala
     430                 435                 440

 tca gtg ttg ctc ttc ctg gcc tgg gtc tgc ttc ctc ttc tac gct ggc     1454
 Ser Val Leu Leu Phe Leu Ala Trp Val Cys Phe Leu Phe Tyr Ala Gly
 445                 450                 455                 460

 att gcc ctc ttc acc agt ggc ttc ctg ctc acc cgt ttg gag ctc acc     1502
 Ile Ala Leu Phe Thr Ser Gly Phe Leu Leu Thr Arg Leu Glu Leu Thr
                 465                 470                 475

 aac cat agc agc tgc caa gag ccc cca ggc cct ggg tcc ctg cca tgg     1550
 Asn His Ser Ser Cys Gln Glu Pro Pro Gly Pro Gly Ser Leu Pro Trp
             480                 485                 490

 ggg agc caa ggg aaa cct ggg gcc tgc tgg atg gct tcc cga ttt tcg     1598
 Gly Ser Gln Gly Lys Pro Gly Ala Cys Trp Met Ala Ser Arg Phe Ser
         495                 500                 505

 cgg gtt gtg ttg gtg ctg ata gat gct ctg cga ttt gac ttc gcc cag     1646
 Arg Val Val Leu Val Leu Ile Asp Ala Leu Arg Phe Asp Phe Ala Gln
     510                 515                 520

 ccc cag cat tca cac gtg cct aga gag cct cct gtc tcc cta ccc ttc     1694
 Pro Gln His Ser His Val Pro Arg Glu Pro Pro Val Ser Leu Pro Phe
 525                 530                 535                 540

 ctg ggc aaa cta agc tcc ttg cag agg atc ctg gag att cag ccc cac     1742
 Leu Gly Lys Leu Ser Ser Leu Gln Arg Ile Leu Glu Ile Gln Pro His
                 545                 550                 555

 cat gcc cgg ctc tac cga tct cag gtt gac cct cct acc acc acc atg     1790
 His Ala Arg Leu Tyr Arg Ser Gln Val Asp Pro Pro Thr Thr Thr Met
             560                 565                 570

 cag cgc ctc aag gcc ctc acc act ggc tca ctg cct acc ttt att gat     1838
 Gln Arg Leu Lys Ala Leu Thr Thr Gly Ser Leu Pro Thr Phe Ile Asp
         575                 580                 585

 gct ggt agt aac ttc gcc agc cac gcc ata gtg gaa gac aat ctc att     1886
 Ala Gly Ser Asn Phe Ala Ser His Ala Ile Val Glu Asp Asn Leu Ile
     590                 595                 600

 aag cag ctc acc agt gca gga agg cgt gta gtc ttc atg gga gat gat     1934
 Lys Gln Leu Thr Ser Ala Gly Arg Arg Val Val Phe Met Gly Asp Asp
 605                 610                 615                 620

 acc tgg aaa gac ctt ttc cct ggt gct ttc tcc aaa gct ttc ttc ttc     1982
 Thr Trp Lys Asp Leu Phe Pro Gly Ala Phe Ser Lys Ala Phe Phe Phe
                 625                 630                 635

 cca tcc ttc aat gtc aga gac cta gac aca gtg gac aat ggc atc ctg     2030
 Pro Ser Phe Asn Val Arg Asp Leu Asp Thr Val Asp Asn Gly Ile Leu
             640                 645                 650

 gaa cac ctc tac ccc acc atg gac agt ggt gaa tgg gac gtg ctg att     2078
 Glu His Leu Tyr Pro Thr Met Asp Ser Gly Glu Trp Asp Val Leu Ile
         655                 660                 665

 gct cac ttc ctg ggt gtg gac cac tgt ggc cac aag cat ggc cct cac     2126
 Ala His Phe Leu Gly Val Asp His Cys Gly His Lys His Gly Pro His
     670                 675                 680

 cac cct gaa atg gcc aag aaa ctt agc cag atg gac cag gtg atc cag     2174
 His Pro Glu Met Ala Lys Lys Leu Ser Gln Met Asp Gln Val Ile Gln
 685                 690                 695                 700

 gga ctt gtg gag cgt ctg gag aat gac aca ctg ctg gta gtg gct ggg     2222
 Gly Leu Val Glu Arg Leu Glu Asn Asp Thr Leu Leu Val Val Ala Gly
                 705                 710                 715

 gac cat ggg atg acc aca aat gga gac cat gga ggg gac agt gag ctg     2270
 Asp His Gly Met Thr Thr Asn Gly Asp His Gly Gly Asp Ser Glu Leu
             720                 725                 730

 gag gtc tca gct gct ctc ttt ctg tat agc ccc aca gca gtc ttc ccc     2318
 Glu Val Ser Ala Ala Leu Phe Leu Tyr Ser Pro Thr Ala Val Phe Pro
         735                 740                 745

 agc acc cca cca gag gag cca gag gtg att cct caa gtt agc ctt gtg     2366
 Ser Thr Pro Pro Glu Glu Pro Glu Val Ile Pro Gln Val Ser Leu Val
     750                 755                 760

 ccc acg ctg gcc ctg ctg ctg ggc ctg ccc atc cca ttt ggg aat atc     2414
 Pro Thr Leu Ala Leu Leu Leu Gly Leu Pro Ile Pro Phe Gly Asn Ile
 765                 770                 775                 780

 ggg gaa gtg atg gct gag cta ttc tca ggg ggt gag gac tcc cag ccc     2462
 Gly Glu Val Met Ala Glu Leu Phe Ser Gly Gly Glu Asp Ser Gln Pro
                 785                 790                 795

 cac tcc tct gct tta gcc caa gcc tca gct ctc cat ctc aat gct cag     2510
 His Ser Ser Ala Leu Ala Gln Ala Ser Ala Leu His Leu Asn Ala Gln
             800                 805                 810

 cag gtg tcc cga ttt ctt cat acc tac tca gct gct act cag gac ctt     2558
 Gln Val Ser Arg Phe Leu His Thr Tyr Ser Ala Ala Thr Gln Asp Leu
         815                 820                 825

 caa gct aag gag ctt cat cag ctg cag aac ctc ttc tcc aag gcc tct     2606
 Gln Ala Lys Glu Leu His Gln Leu Gln Asn Leu Phe Ser Lys Ala Ser
     830                 835                 840

 gct gac tac cag tgg ctt ctc cag agc ccc aag ggg gct gag gcg aca     2654
 Ala Asp Tyr Gln Trp Leu Leu Gln Ser Pro Lys Gly Ala Glu Ala Thr
 845                 850                 855                 860

 ctg ccg act gtg att gct gag ctg cag cag ttc ctg cgg gga gct cgg     2702
 Leu Pro Thr Val Ile Ala Glu Leu Gln Gln Phe Leu Arg Gly Ala Arg
                 865                 870                 875

 gcc atg tgc atc gag tct tgg gct cgt ttc tct ctg gtc cgc atg gcg     2750
 Ala Met Cys Ile Glu Ser Trp Ala Arg Phe Ser Leu Val Arg Met Ala
             880                 885                 890

 ggg ggt act gct ctc ttg gct gct tcc tgc ttt atc tgc ctg ctg gca     2798
 Gly Gly Thr Ala Leu Leu Ala Ala Ser Cys Phe Ile Cys Leu Leu Ala
         895                 900                 905

 tct cag tgg gca ata tcc cca ggc ttt cca ttc tgc cct cta ctc ctg     2846
 Ser Gln Trp Ala Ile Ser Pro Gly Phe Pro Phe Cys Pro Leu Leu Leu
     910                 915                 920

 aca cct gtg gcc tgg ggc ctg gtt ggg gcc ata gcg tat gct gga ctc     2894
 Thr Pro Val Ala Trp Gly Leu Val Gly Ala Ile Ala Tyr Ala Gly Leu
 925                 930                 935                 940

 ctg gga act att gag ctg aag cta gat cta gtg ctt cta ggg gct gtg     2942
 Leu Gly Thr Ile Glu Leu Lys Leu Asp Leu Val Leu Leu Gly Ala Val
                 945                 950                 955

 gct gca gtg agc tca ttc ctc cct ttt ctg tgg aaa gcc tgg gct ggc     2990
 Ala Ala Val Ser Ser Phe Leu Pro Phe Leu Trp Lys Ala Trp Ala Gly
             960                 965                 970

 tgg ggg tcc aag agg ccc ctg gca acc ctg ttt ccc atc cct ggg ccc     3038
 Trp Gly Ser Lys Arg Pro Leu Ala Thr Leu Phe Pro Ile Pro Gly Pro
         975                 980                 985

 gtc ctg tta ctc ctg ctg ttt cgc ttg gct gtg ttc ttc tct gat agt     3086
 Val Leu Leu Leu Leu Leu Phe Arg Leu Ala Val Phe Phe Ser Asp Ser
     990                 995                1000

 ttt gtt gta gct gag gcc agg gcc acc ccc ttc ctt ttg ggc tca ttc     3134
 Phe Val Val Ala Glu Ala Arg Ala Thr Pro Phe Leu Leu Gly Ser Phe
1005                1010                1015                1020

 atc ctg ctc ctg gtt gtc cag ctt cac tgg gag ggc cag ctg ctt cca     3182
 Ile Leu Leu Leu Val Val Gln Leu His Trp Glu Gly Gln Leu Leu Pro
                1025                1030                1035

 cct aag cta ctc aca atg ccc cgc ctt ggc act tca gcc aca aca aac     3230
 Pro Lys Leu Leu Thr Met Pro Arg Leu Gly Thr Ser Ala Thr Thr Asn
            1040                1045                1050

 ccc cca cgg cac aat ggt gca tat gcc ctg agg ctt gga att ggg ttg     3278
 Pro Pro Arg His Asn Gly Ala Tyr Ala Leu Arg Leu Gly Ile Gly Leu
        1055                1060                1065

 ctt tta tgt aca agg cta gct ggg ctt ttt cat cgt tgc cct gaa gag     3326
 Leu Leu Cys Thr Arg Leu Ala Gly Leu Phe His Arg Cys Pro Glu Glu
    1070                1075                1080

 aca cct gtt tgc cac tcc tct ccc tgg ctg agt cct ctg gca tcc atg     3374
 Thr Pro Val Cys His Ser Ser Pro Trp Leu Ser Pro Leu Ala Ser Met
1085                1090                1095                1100

 gtg ggt ggt cga gcc aag aat ttg tgg tat gga gct tgt gtg gcg gcg     3422
 Val Gly Gly Arg Ala Lys Asn Leu Trp Tyr Gly Ala Cys Val Ala Ala
                1105                1110                1115

 ctg gtg gcc ctg tta gct gcc gtg cgc ttg tgg ctt cgc cgc tat ggt     3470
 Leu Val Ala Leu Leu Ala Ala Val Arg Leu Trp Leu Arg Arg Tyr Gly
            1120                1125                1130

 aat ctc aag agc ccc gag cca ccc atg ctc ttt gtg cgc tgg gga ctg     3518
 Asn Leu Lys Ser Pro Glu Pro Pro Met Leu Phe Val Arg Trp Gly Leu
        1135                1140                1145

 ccc cta atg gca ttg ggt act gct gcc tac tgg gca ttg gcg tcg ggg     3566
 Pro Leu Met Ala Leu Gly Thr Ala Ala Tyr Trp Ala Leu Ala Ser Gly
    1150                1155                1160

 gca gat gag gct ccc ccc cgt ctc cgg gtc ctg gtc tct ggg gca tcc     3614
 Ala Asp Glu Ala Pro Pro Arg Leu Arg Val Leu Val Ser Gly Ala Ser
1165                1170                1175                1180

 atg gtg ctg cct cgg gct gta gca ggg ctg gct gct tca ggg ctc gcg     3662
 Met Val Leu Pro Arg Ala Val Ala Gly Leu Ala Ala Ser Gly Leu Ala
                1185                1190                1195

 ctg ctg ctc tgg aag cct gtg aca gtg ctg gtg aag gct ggg gca ggc     3710
 Leu Leu Leu Trp Lys Pro Val Thr Val Leu Val Lys Ala Gly Ala Gly
            1200                1205                1210

 gct cca agg acc agg act gtc ctc act ccc ttc tca ggc ccc ccc act     3758
 Ala Pro Arg Thr Arg Thr Val Leu Thr Pro Phe Ser Gly Pro Pro Thr
        1215                1220                1225

 tct caa gct gac ttg gat tat gtg gtc cct caa atc tac cga cac atg     3806
 Ser Gln Ala Asp Leu Asp Tyr Val Val Pro Gln Ile Tyr Arg His Met
    1230                1235                1240

 cag gag gag ttc cgg ggc cgg tta gag agg acc aaa tct cag ggt ccc     3854
 Gln Glu Glu Phe Arg Gly Arg Leu Glu Arg Thr Lys Ser Gln Gly Pro
1245                1250                1255                1260

 ctg act gtg gct gct tat cag ttg ggg agt gtc tac tca gct gct atg     3902
 Leu Thr Val Ala Ala Tyr Gln Leu Gly Ser Val Tyr Ser Ala Ala Met
                1265                1270                1275

 gtc aca gcc ctc acc ctg ttg gcc ttc cca ctt ctg ctg ttg cat gcg     3950
 Val Thr Ala Leu Thr Leu Leu Ala Phe Pro Leu Leu Leu Leu His Ala
            1280                1285                1290

 gag cgc atc agc ctt gtg ttc ctg ctt ctg ttt ctg cag agc ttc ctt     3998
 Glu Arg Ile Ser Leu Val Phe Leu Leu Leu Phe Leu Gln Ser Phe Leu
        1295                1300                1305

 ctc cta cat ctg ctt gct gct ggg ata ccc gtc acc acc cct ggt aaa     4046
 Leu Leu His Leu Leu Ala Ala Gly Ile Pro Val Thr Thr Pro Gly Lys
    1310                1315                1320

 tat ctc agc tct gat tca ctt aaa gac aat agt gat agt caa ggg ctg     4094
 Tyr Leu Ser Ser Asp Ser Leu Lys Asp Asn Ser Asp Ser Gln Gly Leu
1325                1330                1335                1340

 cgg aag aga cag cag ccc cca ggg aat gaa gct gat gcc aga gtc aga     4142
 Arg Lys Arg Gln Gln Pro Pro Gly Asn Glu Ala Asp Ala Arg Val Arg
                1345                1350                1355

 ccc gag gag gaa gag gag cca ctg atg gag atg cgg ctc cgg gat gcg     4190
 Pro Glu Glu Glu Glu Glu Pro Leu Met Glu Met Arg Leu Arg Asp Ala
            1360                1365                1370

 cct cag cac ttc tat gca gca ctg ctg cag ctg ggc ctc aag tac ctc     4238
 Pro Gln His Phe Tyr Ala Ala Leu Leu Gln Leu Gly Leu Lys Tyr Leu
        1375                1380                1385

 ttt atc ctt ggt att cag att ctg gcc tgt gcc ttg gca gcc tcc atc     4286
 Phe Ile Leu Gly Ile Gln Ile Leu Ala Cys Ala Leu Ala Ala Ser Ile
    1390                1395                1400

 ctt cgc agg cat ctc atg gtc tgg aaa gtg ttt gcc cct aag ttc ata     4334
 Leu Arg Arg His Leu Met Val Trp Lys Val Phe Ala Pro Lys Phe Ile
1405                1410                1415                1420

 ttt gag gct gtg ggc ttc att gtg agc agc gtg gga ctt ctc ctg ggc     4382
 Phe Glu Ala Val Gly Phe Ile Val Ser Ser Val Gly Leu Leu Leu Gly
                1425                1430                1435

 ata gct ttg gtg atg aga gtg gat ggt gct gta ctt ttg agc agt gca     4430
 Ile Ala Leu Val Met Arg Val Asp Gly Ala Val Leu Leu Ser Ser Ala
            1440                1445                1450

 agt aca gag cgg cac tgc cag cag act aca cgc ggt aga aag ccg acc     4478
 Ser Thr Glu Arg His Cys Gln Gln Thr Thr Arg Gly Arg Lys Pro Thr
        1455                1460                1465

 ttg gtg agc gtg ttg gtg ctc gac agt gag cag aga aag gat gga cga     4526
 Leu Val Ser Val Leu Val Leu Asp Ser Glu Gln Arg Lys Asp Gly Arg
    1470                1475                1480

 tta cgg agc gcc ctc gtc tcc agt tac cgc ttt ctg gaa aca cca tcc     4574
 Leu Arg Ser Ala Leu Val Ser Ser Tyr Arg Phe Leu Glu Thr Pro Ser
1485                1490                1495                1500

 gcc ggg gcg gag ctg ttc cgc ccc gcc tcg gcc acc atg tcc cgc cag     4622
 Ala Gly Ala Glu Leu Phe Arg Pro Ala Ser Ala Thr Met Ser Arg Gln
                1505                1510                1515

 acc acc tct gtg ggc tcc agc tgc ctg gac ctg tgg agg gaa aag aat     4670
 Thr Thr Ser Val Gly Ser Ser Cys Leu Asp Leu Trp Arg Glu Lys Asn
            1520                1525                1530

 gac cgg ctc gtt cga cag gcc aag gtg gct cag aac tcc ggt ctg act     4718
 Asp Arg Leu Val Arg Gln Ala Lys Val Ala Gln Asn Ser Gly Leu Thr
        1535                1540                1545

 ctg agg cga cag cag ttg gct cag gat gca ctg gaa ggg ctc aga ggg     4766
 Leu Arg Arg Gln Gln Leu Ala Gln Asp Ala Leu Glu Gly Leu Arg Gly
    1550                1555                1560

 ctc ctc cat agt ctg caa ggg ctc cct gca gct gtt cct gtt ctt ccc     4814
 Leu Leu His Ser Leu Gln Gly Leu Pro Ala Ala Val Pro Val Leu Pro
1565                1570                1575                1580

 ttg gag ctg act gtc acc tgc aac ttc att atc ctg agg gca agc ttg     4862
 Leu Glu Leu Thr Val Thr Cys Asn Phe Ile Ile Leu Arg Ala Ser Leu
                1585                1590                1595

 gcc cag ggt ttc aca gag gat cag gcc cag gat atc cag cgg agc cta     4910
 Ala Gln Gly Phe Thr Glu Asp Gln Ala Gln Asp Ile Gln Arg Ser Leu
            1600                1605                1610

 gag aga gtg ctg gag aca cag gag cag cag ggg ccc agg ttg gaa cag     4958
 Glu Arg Val Leu Glu Thr Gln Glu Gln Gln Gly Pro Arg Leu Glu Gln
        1615                1620                1625

 ggg ctc agg gag ctg tgg gac tct gtc ctt cgt gct tcc tgc ctt ctg     5006
 Gly Leu Arg Glu Leu Trp Asp Ser Val Leu Arg Ala Ser Cys Leu Leu
    1630                1635                1640

 ccg gag ctg ctg tct gcc ctg cac cgc ctg gtt ggc ctg cag gct gcc     5054
 Pro Glu Leu Leu Ser Ala Leu His Arg Leu Val Gly Leu Gln Ala Ala
1645                1650                1655                1660

 ctc tgg ttg agt gct gac cgt ctt ggg gac ctg gcc ttg tta cta gag     5102
 Leu Trp Leu Ser Ala Asp Arg Leu Gly Asp Leu Ala Leu Leu Leu Glu
                1665                1670                1675

 acc ctg aat ggc agc cag agt gga gcc tct aag gat ctg ctg tta ctt     5150
 Thr Leu Asn Gly Ser Gln Ser Gly Ala Ser Lys Asp Leu Leu Leu Leu
            1680                1685                1690

 ctg aaa act tgg agt ccc cca gct gag gaa tta gat gct cca ttg acc     5198
 Leu Lys Thr Trp Ser Pro Pro Ala Glu Glu Leu Asp Ala Pro Leu Thr
        1695                1700                1705

 ctg cag gat gcc cag gga ttg aag gat gtc ctc ctg aca gca ttt gcc     5246
 Leu Gln Asp Ala Gln Gly Leu Lys Asp Val Leu Leu Thr Ala Phe Ala
    1710                1715                1720

 tac cgc caa ggt ctc cag gag ctg atc aca ggg aac cca gac aag gca     5294
 Tyr Arg Gln Gly Leu Gln Glu Leu Ile Thr Gly Asn Pro Asp Lys Ala
1725                1730                1735                1740

 cta agc agc ctt cat gaa gcg gcc tca ggc ctg tgt cca cgg cct gtg     5342
 Leu Ser Ser Leu His Glu Ala Ala Ser Gly Leu Cys Pro Arg Pro Val
                1745                1750                1755

 ttg gtc cag gtg tac aca gca ctg ggg tcc tgt cac cgt aag atg gga     5390
 Leu Val Gln Val Tyr Thr Ala Leu Gly Ser Cys His Arg Lys Met Gly
            1760                1765                1770

 aat cca cag aga gca ctg ttg tac ttg gtt gca gcc ctg aaa gag gga     5438
 Asn Pro Gln Arg Ala Leu Leu Tyr Leu Val Ala Ala Leu Lys Glu Gly
        1775                1780                1785

 tca gcc tgg ggt cct cca ctt ctg gag gcc tct agg ctc tat cag caa     5486
 Ser Ala Trp Gly Pro Pro Leu Leu Glu Ala Ser Arg Leu Tyr Gln Gln
    1790                1795                1800

 ctg ggg gac aca aca gca gag ctg gag agt ctg gag ctg cta gtt gag     5534
 Leu Gly Asp Thr Thr Ala Glu Leu Glu Ser Leu Glu Leu Leu Val Glu
1805                1810                1815                1820

 gcc ttg aat gtc cca tgc agt tcc aaa gcc ccg cag ttt ctc att gag     5582
 Ala Leu Asn Val Pro Cys Ser Ser Lys Ala Pro Gln Phe Leu Ile Glu
                1825                1830                1835

 gta gaa tta cta ctg cca cca cct gac cta gcc tca ccc ctt cat tgt     5630
 Val Glu Leu Leu Leu Pro Pro Pro Asp Leu Ala Ser Pro Leu His Cys
            1840                1845                1850

 ggc act cag agc cag acc aag cac ata cta gca agc agg tgc cta cag     5678
 Gly Thr Gln Ser Gln Thr Lys His Ile Leu Ala Ser Arg Cys Leu Gln
        1855                1860                1865

 acg ggg agg gca gga gac gct gca gag cat tac ttg gac ctg ctg gcc     5726
 Thr Gly Arg Ala Gly Asp Ala Ala Glu His Tyr Leu Asp Leu Leu Ala
    1870                1875                1880

 ctg ttg ctg gat agc tcg gag cca agg gtg ggg ccc tgt atg cct gag     5774
 Leu Leu Leu Asp Ser Ser Glu Pro Arg Val Gly Pro Cys Met Pro Glu
1885                1890                1895                1900

 gtg ttt ttg gag gca gcg gta gca ctg atc cag gca ggc aga gcc caa     5822
 Val Phe Leu Glu Ala Ala Val Ala Leu Ile Gln Ala Gly Arg Ala Gln
                1905                1910                1915

 gat gcc ttg act cta tgt gag gag ttg ctc agc cgc aca tca tct ctg     5870
 Asp Ala Leu Thr Leu Cys Glu Glu Leu Leu Ser Arg Thr Ser Ser Leu
            1920                1925                1930

 cta ccc aag atg tcc cgg ctg tgg gaa gat gcc aga aaa gga acc aag     5918
 Leu Pro Lys Met Ser Arg Leu Trp Glu Asp Ala Arg Lys Gly Thr Lys
        1935                1940                1945

 gaa ctg cca tac tgc cca ctc tgg gtc tct gcc acc cac ctg ctt cag     5966
 Glu Leu Pro Tyr Cys Pro Leu Trp Val Ser Ala Thr His Leu Leu Gln
    1950                1955                1960

 ggc cag gcc tgg gtt caa ctg ggt gcc caa aaa gtg gca att agt gaa     6014
 Gly Gln Ala Trp Val Gln Leu Gly Ala Gln Lys Val Ala Ile Ser Glu
1965                1970                1975                1980

 ttt agc agg tgc ctc gag ctg ctc ttc cgg gcc aca cct gag gaa aaa     6062
 Phe Ser Arg Cys Leu Glu Leu Leu Phe Arg Ala Thr Pro Glu Glu Lys
                1985                1990                1995

 gaa caa ggg gca gct ttc aac tgt gag cag gga tgt aag tca gat gcg     6110
 Glu Gln Gly Ala Ala Phe Asn Cys Glu Gln Gly Cys Lys Ser Asp Ala
            2000                2005                2010

 gca ctg cag cag ctt cgg gca gcc gcc cta att agt cgt gga ctg gaa     6158
 Ala Leu Gln Gln Leu Arg Ala Ala Ala Leu Ile Ser Arg Gly Leu Glu
        2015                2020                2025

 tgg gta gcc agc ggc cag gat acc aaa gcc tta cag gac ttc ctc ctc     6206
 Trp Val Ala Ser Gly Gln Asp Thr Lys Ala Leu Gln Asp Phe Leu Leu
    2030                2035                2040

 agt gtg cag atg tgc cca gtc tca gcg aag cgt ctg cga ccg tcg ttt     6254
 Ser Val Gln Met Cys Pro Val Ser Ala Lys Arg Leu Arg Pro Ser Phe
2045                2050                2055                2060

 gag tcg tcg ctg ccg ctg ccg ctg cca ctg cca ctg cca cct cgc gga     6302
 Glu Ser Ser Leu Pro Leu Pro Leu Pro Leu Pro Leu Pro Pro Arg Gly
                2065                2070                2075

 tca gga gcc agc gtt gtt cgc ccg acg cct cgc tgc cgg ccc cgg ccc     6350
 Ser Gly Ala Ser Val Val Arg Pro Thr Pro Arg Cys Arg Pro Arg Pro
            2080                2085                2090

 gcc cga ttg gct ccc tta gaa cgg acg tct ggg cct ggc cag gtc ttc     6398
 Ala Arg Leu Ala Pro Leu Glu Arg Thr Ser Gly Pro Gly Gln Val Phe
        2095                2100                2105

 cgg ccc act ccg ccg ggg cgg cgc ccc ggg gct ttg ggg cgc cag tct     6446
 Arg Pro Thr Pro Pro Gly Arg Arg Pro Gly Ala Leu Gly Arg Gln Ser
    2110                2115                2120

 gcc gtc cgg cct acc acc cgc cga aag cct ttg gtc ccc gga gag agc     6494
 Ala Val Arg Pro Thr Thr Arg Arg Lys Pro Leu Val Pro Gly Glu Ser
2125                2130                2135                2140

 agg ccc cgc gag ccc gag gcc cca gcc ggg ccc gag gag gac atc aaa     6542
 Arg Pro Arg Glu Pro Glu Ala Pro Ala Gly Pro Glu Glu Asp Ile Lys
                2145                2150                2155

 gtt cag agg tta ggt aac ttg ccc aag atc aca att aag cag tgg cat     6590
 Val Gln Arg Leu Gly Asn Leu Pro Lys Ile Thr Ile Lys Gln Trp His
            2160                2165                2170

 aat tgg aat tca gac cca atg ggt ctg act ata gag ttc ctg ctc tta     6638
 Asn Trp Asn Ser Asp Pro Met Gly Leu Thr Ile Glu Phe Leu Leu Leu
        2175                2180                2185

 acc act ctt ctt tca aaa ggt gat gac cta tca aca gcc att ctc aaa     6686
 Thr Thr Leu Leu Ser Lys Gly Asp Asp Leu Ser Thr Ala Ile Leu Lys
    2190                2195                2200

 cag aag aac cgt ccc aat cgg tta att gtt gat gaa gcc atc aat gag     6734
 Gln Lys Asn Arg Pro Asn Arg Leu Ile Val Asp Glu Ala Ile Asn Glu
2205                2210                2215                2220

 gac aac agt gtg gtg tcc ttg tcc cag ccc aag atg gat gaa ttg cag     6782
 Asp Asn Ser Val Val Ser Leu Ser Gln Pro Lys Met Asp Glu Leu Gln
                2225                2230                2235

 ttg ttc cga ggt gac aca gtg ttg ctg aaa gga aag aag aga cga gaa     6830
 Leu Phe Arg Gly Asp Thr Val Leu Leu Lys Gly Lys Lys Arg Arg Glu
            2240                2245                2250

 gct gtt tgc atc gtc ctt tct gat gat act tgt tct gat gag aag att     6878
 Ala Val Cys Ile Val Leu Ser Asp Asp Thr Cys Ser Asp Glu Lys Ile
        2255                2260                2265

 cgg atg aat aga gtt gtt cgg aat aac ctt cgt gta cgc cta ggg gat     6926
 Arg Met Asn Arg Val Val Arg Asn Asn Leu Arg Val Arg Leu Gly Asp
    2270                2275                2280

 gtc atc agc atc cag cca tgc cct gat gtg aag tac ggc aaa cgt atc     6974
 Val Ile Ser Ile Gln Pro Cys Pro Asp Val Lys Tyr Gly Lys Arg Ile
2285                2290                2295                2300

 cat gtg ctg ccc att gat gac aca gtg gaa ggc att act ggt aat ctc     7022
 His Val Leu Pro Ile Asp Asp Thr Val Glu Gly Ile Thr Gly Asn Leu
                2305                2310                2315

 ttc gag gta tac ctt aag ccg tac ttc ctg gaa gcg tat cga ccc atc     7070
 Phe Glu Val Tyr Leu Lys Pro Tyr Phe Leu Glu Ala Tyr Arg Pro Ile
            2320                2325                2330

 cgg aaa gga gac att ttt ctt gtc cgt ggt ggg atg cgt gct gtg gag     7118
 Arg Lys Gly Asp Ile Phe Leu Val Arg Gly Gly Met Arg Ala Val Glu
        2335                2340                2345

 ttc aaa gtg gtg gaa aca gat cct agc cct tat tgc att gtt gct cca     7166
 Phe Lys Val Val Glu Thr Asp Pro Ser Pro Tyr Cys Ile Val Ala Pro
    2350                2355                2360

 gac aca gtg atc cac tgc gaa ggg gag cct atc aaa cga gag gat gag     7214
 Asp Thr Val Ile His Cys Glu Gly Glu Pro Ile Lys Arg Glu Asp Glu
2365                2370                2375                2380

 gaa gag tcc ttg aat gaa gta ggg tat gat gac att ggt ggc tgc agg     7262
 Glu Glu Ser Leu Asn Glu Val Gly Tyr Asp Asp Ile Gly Gly Cys Arg
                2385                2390                2395

 aag cag cta gct cag ata aag gag atg gtg gaa ctg ccc ctg aga cat     7310
 Lys Gln Leu Ala Gln Ile Lys Glu Met Val Glu Leu Pro Leu Arg His
            2400                2405                2410

 cct gcc ctc ttt aag gca att ggt gtg aag cct cct aga gga atc ctg     7358
 Pro Ala Leu Phe Lys Ala Ile Gly Val Lys Pro Pro Arg Gly Ile Leu
        2415                2420                2425

 ctt tac gga cct cct gga aca gga aag acc ctg att gct cga gct gta     7406
 Leu Tyr Gly Pro Pro Gly Thr Gly Lys Thr Leu Ile Ala Arg Ala Val
    2430                2435                2440

 gca aat gag act gga gcc ttc ttc ttc ttg atc aat ggt cct gag atc     7454
 Ala Asn Glu Thr Gly Ala Phe Phe Phe Leu Ile Asn Gly Pro Glu Ile
2445                2450                2455                2460

 atg agc aaa ttg gct ggt gag tct gag agc aac ctt cgt aaa gcc ttt     7502
 Met Ser Lys Leu Ala Gly Glu Ser Glu Ser Asn Leu Arg Lys Ala Phe
                2465                2470                2475

 gag gag gct gag aag aat gct cct gcc atc atc ttc att gat gag cta     7550
 Glu Glu Ala Glu Lys Asn Ala Pro Ala Ile Ile Phe Ile Asp Glu Leu
            2480                2485                2490

 gat gcc atc gct ccc aaa aga gag aaa act cat ggc gag gtg gag cgg     7598
 Asp Ala Ile Ala Pro Lys Arg Glu Lys Thr His Gly Glu Val Glu Arg
        2495                2500                2505

 cgc att gta tca cag ttg ttg acc ctc atg gat ggc cta aag cag agg     7646
 Arg Ile Val Ser Gln Leu Leu Thr Leu Met Asp Gly Leu Lys Gln Arg
    2510                2515                2520

 gca cat gtg att gtt atg gca gca acc aac aga ccc aac agc att gac     7694
 Ala His Val Ile Val Met Ala Ala Thr Asn Arg Pro Asn Ser Ile Asp
2525                2530                2535                2540

 cca gct cta cgg cga ttt ggt cgc ttt gac agg gag gta gat att gga     7742
 Pro Ala Leu Arg Arg Phe Gly Arg Phe Asp Arg Glu Val Asp Ile Gly
                2545                2550                2555

 att cct gat gct aca gga cgc tta gag att ctt cag atc cat acc aag     7790
 Ile Pro Asp Ala Thr Gly Arg Leu Glu Ile Leu Gln Ile His Thr Lys
            2560                2565                2570

 aac atg aag ctg gca gat gat gtg gac ctg gaa cag gta gcc aat gag     7838
 Asn Met Lys Leu Ala Asp Asp Val Asp Leu Glu Gln Val Ala Asn Glu
        2575                2580                2585

 act cac ggg cat gtg ggt gct gac tta gca gcc ctg tgc tca gag gct     7886
 Thr His Gly His Val Gly Ala Asp Leu Ala Ala Leu Cys Ser Glu Ala
    2590                2595                2600

 gct ctg caa gcc atc cgc aag aag atg gat ctc att gac cta gag gat     7934
 Ala Leu Gln Ala Ile Arg Lys Lys Met Asp Leu Ile Asp Leu Glu Asp
2605                2610                2615                2620

 gag acc att gat gcc gag gtc atg aac tct cta gca gtt act atg gat     7982
 Glu Thr Ile Asp Ala Glu Val Met Asn Ser Leu Ala Val Thr Met Asp
                2625                2630                2635

 gac ttc cgg gta agg acc aca ccc gtg cct cag tgg gcc ttg agc cag     8030
 Asp Phe Arg Val Arg Thr Thr Pro Val Pro Gln Trp Ala Leu Ser Gln
            2640                2645                2650

 agt aac cca tca gca ctg cgg gaa acc gtg gta gag gtg cca cag gta     8078
 Ser Asn Pro Ser Ala Leu Arg Glu Thr Val Val Glu Val Pro Gln Val
        2655                2660                2665

 acc tgg gaa gac atc ggg ggc cta gag gat gtc aaa cgt gag cta cag     8126
 Thr Trp Glu Asp Ile Gly Gly Leu Glu Asp Val Lys Arg Glu Leu Gln
    2670                2675                2680

 gag ctg gtc cag tat cct gtg gag cac cca gac aaa ttc ctg aag ttt     8174
 Glu Leu Val Gln Tyr Pro Val Glu His Pro Asp Lys Phe Leu Lys Phe
2685                2690                2695                2700

 ggc atg aca cct tcc aag gga gtt ctg ttc tat gga cct cct ggc tgt     8222
 Gly Met Thr Pro Ser Lys Gly Val Leu Phe Tyr Gly Pro Pro Gly Cys
                2705                2710                2715

 ggg aaa act ttg ttg gcc aaa gcc att gct aat gaa tgc cag gcc aac     8270
 Gly Lys Thr Leu Leu Ala Lys Ala Ile Ala Asn Glu Cys Gln Ala Asn
            2720                2725                2730

 ttc atc tcc atc aag ggt cct gag ctg ctc acc atg tgg ttt ggg gag     8318
 Phe Ile Ser Ile Lys Gly Pro Glu Leu Leu Thr Met Trp Phe Gly Glu
        2735                2740                2745

 tct gag gcc aat gtc aga gaa atc ttt gac aag gcc cgc caa gct gcc     8366
 Ser Glu Ala Asn Val Arg Glu Ile Phe Asp Lys Ala Arg Gln Ala Ala
    2750                2755                2760

 ccc tgt gtg cta ttc ttt gat gag ctg gat tcg att gcc aag gct cgt     8414
 Pro Cys Val Leu Phe Phe Asp Glu Leu Asp Ser Ile Ala Lys Ala Arg
2765                2770                2775                2780

 gga ggt aac att gga gat ggt ggt ggg gct gct gac cga gtc atc aac     8462
 Gly Gly Asn Ile Gly Asp Gly Gly Gly Ala Ala Asp Arg Val Ile Asn
                2785                2790                2795

 cag atc ctg aca gaa atg gat ggc atg tcc aca aaa aaa aat gtg ttc     8510
 Gln Ile Leu Thr Glu Met Asp Gly Met Ser Thr Lys Lys Asn Val Phe
            2800                2805                2810

 atc att ggc gct acc aac cgg cct gac atc att gat cct gcc atc ctc     8558
 Ile Ile Gly Ala Thr Asn Arg Pro Asp Ile Ile Asp Pro Ala Ile Leu
        2815                2820                2825

 aga cct ggc cgt ctt gat cag ctc atc tac atc cca ctt cct gat gag     8606
 Arg Pro Gly Arg Leu Asp Gln Leu Ile Tyr Ile Pro Leu Pro Asp Glu
    2830                2835                2840

 aag tcc cgt gtt gcc atc ctc aag gct aac ctg cgc aag tcc cca gtt     8654
 Lys Ser Arg Val Ala Ile Leu Lys Ala Asn Leu Arg Lys Ser Pro Val
2845                2850                2855                2860

 gcc aag gca ggt gca aga tca tgg gct gat gtg gac ttg gag ttc ctg     8702
 Ala Lys Ala Gly Ala Arg Ser Trp Ala Asp Val Asp Leu Glu Phe Leu
                2865                2870                2875

 gct aaa atg act aat ggc ttc tct gga gct gac ctg aca gag att tgc     8750
 Ala Lys Met Thr Asn Gly Phe Ser Gly Ala Asp Leu Thr Glu Ile Cys
            2880                2885                2890

 cag cgt gct tgc aag ctg gcc atc cgt gaa tcc atc gag agt gag att     8798
 Gln Arg Ala Cys Lys Leu Ala Ile Arg Glu Ser Ile Glu Ser Glu Ile
        2895                2900                2905

 agg cga gaa cga gag agg cag aca aac cca tca gcc atg gag gta gaa     8846
 Arg Arg Glu Arg Glu Arg Gln Thr Asn Pro Ser Ala Met Glu Val Glu
    2910                2915                2920

 gag gat gat cca gtg cct gag atc cgt cga gat cac ttt gaa gaa gcc     8894
 Glu Asp Asp Pro Val Pro Glu Ile Arg Arg Asp His Phe Glu Glu Ala
2925                2930                2935                2940

 atg cgc ttt gcg cgc cgt tct gtc agt gac aat gac att cgg aag tat     8942
 Met Arg Phe Ala Arg Arg Ser Val Ser Asp Asn Asp Ile Arg Lys Tyr
                2945                2950                2955

 gag atg ttt gcc cag acc ctt cag cag agt cgg ggc ttt ggc agc ttc     8990
 Glu Met Phe Ala Gln Thr Leu Gln Gln Ser Arg Gly Phe Gly Ser Phe
            2960                2965                2970

 aga ttc cct tca ggg aac cag ggt gga gct ggc ccc agt cag ggc agt     9038
 Arg Phe Pro Ser Gly Asn Gln Gly Gly Ala Gly Pro Ser Gln Gly Ser
        2975                2980                2985

 gga ggc ggc aca ggt ggc agt gta tac aca gaa gac aat gat gat gac     9086
 Gly Gly Gly Thr Gly Gly Ser Val Tyr Thr Glu Asp Asn Asp Asp Asp
    2990                2995                3000

 ctg tat ggc taa                                                     9098
 Leu Tyr Gly 
3005





      <210> 35
      <211> 1193
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (487)..(948)

      <400> 35
 gacagggagg gaggaagcct aggagtccgc cgcgggacgg aggcctgggg gaactgggag     60

 ttcagctttc tgcagagggc cactaggaac ctcggattgc ccacggaagc cagccacttt    120

 ctttgacagt ccagcccacc tcctcttctg cccggagaag ctccaggggc tgcctttgtg    180

 atcacagcat cttcacaagg accaaaggaa aataagattt ctcgtaagaa caccgtgacc    240

 acatctttaa aatgacccat ttcgtggctc ccacaagatt tacacctcca cactgaggcc    300

 ggaagtggtt ttgcccctat aaaacatggc gaaaagcttt cttgtctcca aggaaacgcc    360

 acgtaatgag tcaaagctgt ggcgcacgcg cagaagtaca agctaccgga agtgatggcg    420

 cccctactaa agccttgggg ttagtacgcg tgcgcagcag tctcttccga cagttgtgtt    480

 gtgcca   atg gtg gag aag aaa act tcg gtt cgc tcc cag gac ccc ggg     528
          Met Val Glu Lys Lys Thr Ser Val Arg Ser Gln Asp Pro Gly
            1               5                  10

 cag cgg cgg gtg ctg gac cgg gct gcc cgg cag cgt cgc atc aac cgg      576
 Gln Arg Arg Val Leu Asp Arg Ala Ala Arg Gln Arg Arg Ile Asn Arg
  15                  20                  25                  30

 cag ctg gag gcc ctg gag aat gac aac ttc cag gat gac ccc cac gcg      624
 Gln Leu Glu Ala Leu Glu Asn Asp Asn Phe Gln Asp Asp Pro His Ala
                  35                  40                  45

 gga ctc cct cag ctc ggc aag aga ctg cct cag ttt gat gac gat gcg      672
 Gly Leu Pro Gln Leu Gly Lys Arg Leu Pro Gln Phe Asp Asp Asp Ala
              50                  55                  60

 gac act gga aag aaa aag aag aaa acc cga ggt gat cat ttt aaa ctt      720
 Asp Thr Gly Lys Lys Lys Lys Lys Thr Arg Gly Asp His Phe Lys Leu
          65                  70                  75

 cgc ttc cga aaa aac ttt cag gcc ctg ttg gag gag cag aac ttg agt      768
 Arg Phe Arg Lys Asn Phe Gln Ala Leu Leu Glu Glu Gln Asn Leu Ser
      80                  85                  90

 gtg gcc gag ggc cct aac tac ctg acg gcc tgt gcg gga ccc cca tcg      816
 Val Ala Glu Gly Pro Asn Tyr Leu Thr Ala Cys Ala Gly Pro Pro Ser
  95                 100                 105                 110

 cgg ccc cag cgc ccc ttc tgt gct gtc tgt ggc ttc cca tcc ccc tac      864
 Arg Pro Gln Arg Pro Phe Cys Ala Val Cys Gly Phe Pro Ser Pro Tyr
                 115                 120                 125

 acc tgt gtc agc tgc ggt gcc cgg tac tgc act gtg cgc tgt ctg ggg      912
 Thr Cys Val Ser Cys Gly Ala Arg Tyr Cys Thr Val Arg Cys Leu Gly
             130                 135                 140

 acc cac cag gag acc agg tgt ctg aag tgg act gtg tgag cctgggcatt      962
 Thr His Gln Glu Thr Arg Cys Leu Lys Trp Thr Val 
         145                 150

 cccagagagg aagggccgct gtgcactgcc cggccttcag aaagacagaa tttcatcacc   1022

 caatgcaggg ggagctcttc ctggaccaag ggaggagccg ctcattcacc caacaaaact   1082

 gtgtcttatc tgccaggaaa gaccagcctc actcctggga actgtctggc aggtaggctg   1142

 ggccccccag tgctgttaga ataaaaagcc tcgtgccgga aaaaaaaaaa a            1193




      <210> 36
      <211> 1460
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (230)..(811)

      <400> 36
 cgacccacgc gtccgggagt ccacacaggc agttggaaca actggaaagc gggaggaaat     60

 aatggaaagt ctgctgacct tctcgtctta caaccaccat ataattcatg gatgacagac    120

 tttgagaagg ttcctgccct caggggcttg gtctcctctt ctgcaaggat caatacaaat    180

 tggcgacatt ttttccaaac tacttgacct tgaccagata gtcttcaag    atg cca     235
                                                          Met Pro
                                                            1

 aac tgg ggc gga ggc gca aaa tgt gga gcc tgt gaa aag acc gtc tac      283
 Asn Trp Gly Gly Gly Ala Lys Cys Gly Ala Cys Glu Lys Thr Val Tyr
           5                  10                  15

 cat gca gaa gaa atc cag tgc aat gga agg agt ttc cac aag acg tgt      331
 His Ala Glu Glu Ile Gln Cys Asn Gly Arg Ser Phe His Lys Thr Cys
      20                  25                  30

 ttc cac tgc atg gcc tgc agg aag gct ctt gac agc acg aca gtc gcg      379
 Phe His Cys Met Ala Cys Arg Lys Ala Leu Asp Ser Thr Thr Val Ala
  35                  40                  45                  50

 gct cat gag tcg gag atc tac tgc aag gtg tgc tat ggg cgc aga tat      427
 Ala His Glu Ser Glu Ile Tyr Cys Lys Val Cys Tyr Gly Arg Arg Tyr
                  55                  60                  65

 ggc ccc aaa ggg atc ggg tat gga caa ggc gct ggc tgt ctc agc aca      475
 Gly Pro Lys Gly Ile Gly Tyr Gly Gln Gly Ala Gly Cys Leu Ser Thr
              70                  75                  80

 gac acg ggc gag cat ctc ggc ctg cag ttc caa cag tcc cca aag ccg      523
 Asp Thr Gly Glu His Leu Gly Leu Gln Phe Gln Gln Ser Pro Lys Pro
          85                  90                  95

 gca cgc tca gtt acc acc agc aac cct tcc aaa ttc act gcg aag ttt      571
 Ala Arg Ser Val Thr Thr Ser Asn Pro Ser Lys Phe Thr Ala Lys Phe
     100                 105                 110

 gga gag tcc gag aag tgc cct cga tgt ggc aag tca gtc tat gct gct      619
 Gly Glu Ser Glu Lys Cys Pro Arg Cys Gly Lys Ser Val Tyr Ala Ala
 115                 120                 125                 130

 gag aag gtt atg gga ggt ggc aag cct tgg cac aag acc tgt ttc cgc      667
 Glu Lys Val Met Gly Gly Gly Lys Pro Trp His Lys Thr Cys Phe Arg
                 135                 140                 145

 tgt gcc atc tgt ggg aag agt ctg gag tcc aca aat gtc act gac aaa      715
 Cys Ala Ile Cys Gly Lys Ser Leu Glu Ser Thr Asn Val Thr Asp Lys
             150                 155                 160

 gat ggg gaa ctt tat tgc aaa gtt tgc tat gcc aaa aat ttt ggc ccc      763
 Asp Gly Glu Leu Tyr Cys Lys Val Cys Tyr Ala Lys Asn Phe Gly Pro
         165                 170                 175

 acg ggt att ggg ttt gga ggc ctt aca caa caa gtg gaa aag aaa gaa      811
 Thr Gly Ile Gly Phe Gly Gly Leu Thr Gln Gln Val Glu Lys Lys Glu 
     180                 185                 190

 tgaagaggtg cgccgtttct cagatttttt gcgagcctaa aacacttgcc aagtaatcct    871

 gcacagatcg atacctttcc ccaaatagcc tctcctttgt agtcgtacat tatgtgtttc    931

 tcctcagaag tgatcaggtc tttactgaat gttagaagag gcctttggaa gaaaattatg    991

 taaagtttaa tctataacaa atgctttatt atttataatg cttggaatgg gagaggcaat   1051

 aaataaatgt tttagtgcta tcttgtatgg ctctagatct tttctttgag atagaaattt   1111

 tcaaaaacat aaagctagtt caaaaaacga gttgcagagc atataataaa tttggatgtc   1171

 aactgagaaa ggagtgagaa ggaagaaaca atgcgcaaag gaaagcagtc tttcagaatc   1231

 tgtcagccaa gtgtctttct agttactgct aatggagaag aaaacagggg gtctgggaga   1291

 aaatagagaa catgatagca aaatctaaaa ggaaaatcaa aactaataaa attgctgaag   1351

 agttgatccc tttgtcctat cgtggggctt tgtaatgtta cacatctcgt gaaaactcag   1411

 aaatgacaat aaagcgtggc atttgcctct gtattataaa aaaaaaaaa               1460




      <210> 37
      <211> 1208
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (341)..(1003)

      <400> 37
 ggaattcccg ggtcgacgat ttcgtgtggc tcagtcttgg ctcattgaaa ccttcacctc     60

 ctgggttcaa gcgattctcc tgcctcagcc tcctgagtag ctgggattac aaccgtatgc    120

 cacaacgtcc ggctaatttt gtaattttag tagagacagg gtttcaccat gttggccagg    180

 ctggtctcaa actcctgacc tcaggtgatc cgctcacctc ggcctcccaa agtgctggga    240

 ttacaggtgt gagccagcgc ctggcttagg ggccatcttt gagtcggccc tggctctgct    300

 ccccaggtct cagtgctgtg ccccccccag agcctagagg  atg ttt cat ggg atc     355
                                              Met Phe His Gly Ile
                                                1               5

 cca gcc acg ccg ggc ata gga gcc cct ggg aac aag ccg gag ctg tat      403
 Pro Ala Thr Pro Gly Ile Gly Ala Pro Gly Asn Lys Pro Glu Leu Tyr
                  10                  15                  20

 gag gaa gtg aag ttg tac aag aac gcc cgg gag agg gag aag tac gac      451
 Glu Glu Val Lys Leu Tyr Lys Asn Ala Arg Glu Arg Glu Lys Tyr Asp
              25                  30                  35

 aac atg gca gag ctg ttt gcg gtg gtg aag aca atg caa gcc ctg gag      499
 Asn Met Ala Glu Leu Phe Ala Val Val Lys Thr Met Gln Ala Leu Glu
          40                  45                  50

 aag gcc tac atc aag gac tgt gtc tcc ccc agc gag tac act gca gcc      547
 Lys Ala Tyr Ile Lys Asp Cys Val Ser Pro Ser Glu Tyr Thr Ala Ala
      55                  60                  65

 tgc tcc cgg ctc ctg gtc caa tac aaa gct gcc ttc agg cag gtc cag      595
 Cys Ser Arg Leu Leu Val Gln Tyr Lys Ala Ala Phe Arg Gln Val Gln
  70                  75                  80                  85

 ggc tca gaa atc agc tct att gac gaa ttc tgc cgc aag ttc cgc ctg      643
 Gly Ser Glu Ile Ser Ser Ile Asp Glu Phe Cys Arg Lys Phe Arg Leu
                  90                  95                 100

 gac tgc ccg ctg gcc atg gag cgg atc aag gag gac cgg ccc atc acc      691
 Asp Cys Pro Leu Ala Met Glu Arg Ile Lys Glu Asp Arg Pro Ile Thr
             105                 110                 115

 atc aag gac gac aag ggc aac ctc aac cgc tgc atc gca gac gtg gtc      739
 Ile Lys Asp Asp Lys Gly Asn Leu Asn Arg Cys Ile Ala Asp Val Val
         120                 125                 130

 tcg ctc ttc atc acg gtc atg gac aag ctg cgc ctg gag atc cgc gcc      787
 Ser Leu Phe Ile Thr Val Met Asp Lys Leu Arg Leu Glu Ile Arg Ala
     135                 140                 145

 atg gat gag atc cag ccc gac ctg cga gag ctg atg gag acc atg cac      835
 Met Asp Glu Ile Gln Pro Asp Leu Arg Glu Leu Met Glu Thr Met His
 150                 155                 160                 165

 cgc atg agc cac ctc cca ccc gac ttt gag ggc cgc cag acg gtc agc      883
 Arg Met Ser His Leu Pro Pro Asp Phe Glu Gly Arg Gln Thr Val Ser
                 170                 175                 180

 cag tgg ctg cag acc ctg agc ggc atg tcg gcg tca gat gag ctg gac      931
 Gln Trp Leu Gln Thr Leu Ser Gly Met Ser Ala Ser Asp Glu Leu Asp
             185                 190                 195

 gac tca cag gtg cgt cag atg ctg ttc gac ctg gag tca gcc tac aac      979
 Asp Ser Gln Val Arg Gln Met Leu Phe Asp Leu Glu Ser Ala Tyr Asn
         200                 205                 210

 gcc ttc aac cgc ttc ctg cat gcc tgagcccggg gcactagccc ttgcacagaa    1033
 Ala Phe Asn Arg Phe Leu His Ala 
     215                 220

 gggcagagtc tgaggcgatg gctcctggtc ccctgtccgc cacacaggcc gtggtcatcc   1093

 acacaactca ctgtctgcag ctgcctgtct ggtgtctgtc tttggtgtca gaactttggg   1153

 ggccgggccc ctccccacaa taaagatgct ctccgacctt cctaaaaaaa aaaaa        1208




      <210> 38
      <211> 1062
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (140)..(820)

      <220>
      <221> misc_feature
      <222> (1)...(1062)
      <223> n = a,t,c or g

      <400> 38
 aaagacagag acaccaagaa gaatcggaac atacaggctt tgatatcaaa ggtttataaa     60

 gccaatatct gggaaagaga aaaccgtgag acttccagat cttctctggt gaagtgtgtt    120

 tcctgcaacg atcacgaac atg aac atc aaa gga tcg cca tgg aaa ggg tcc     172
                      Met Asn Ile Lys Gly Ser Pro Trp Lys Gly Ser
                        1               5                  10

 ctc ctg ctg ctg ctg gtg tca aac ctg ctc ctg tgc cag agc gtg gcc      220
 Leu Leu Leu Leu Leu Val Ser Asn Leu Leu Leu Cys Gln Ser Val Ala
              15                  20                  25

 ccc ttg ccc atc tgt ccc ggc ggg gct gcc cga tgc cag gtg acc ctt      268
 Pro Leu Pro Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu
          30                  35                  40

 cga gac ctg ttt gac cgc gcc gtc gtc ctg tcc cac tac atc cat aac      316
 Arg Asp Leu Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn
      45                  50                  55

 ctc tcc tca gaa atg ttc agc gaa ttc gat aaa cgg tat acc cat ggc      364
 Leu Ser Ser Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly
  60                  65                  70                  75

 cgg ggg ttc att acc aag gcc atc aac agc tgc cac act tct tcc ctt      412
 Arg Gly Phe Ile Thr Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu
                  80                  85                  90

 gcc acc ccc gaa gac aag gag caa gcc caa cag atg aat caa aaa gac      460
 Ala Thr Pro Glu Asp Lys Glu Gln Ala Gln Gln Met Asn Gln Lys Asp
              95                 100                 105

 ttt ctg agc ctg ata gtc agc ata ttg cga tcc tgg aat gag cct ctg      508
 Phe Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu
         110                 115                 120

 tat cat ctg gtc acg gaa gta cgt ggt atg caa gaa gcc ccc gag gct      556
 Tyr His Leu Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala
     125                 130                 135

 atc cta tcc aaa gct gta gag att gag gag caa acc aaa cgg ctt cta      604
 Ile Leu Ser Lys Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu
 140                 145                 150                 155

 gag ggc atg gag ctg ata gtc agc cag gtt cat cct gaa acc aaa gaa      652
 Glu Gly Met Glu Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu
                 160                 165                 170

 aat gag atc tac cct gtc tgg tcg gga ctt cca tcc ctg cag atg gct      700
 Asn Glu Ile Tyr Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala
             175                 180                 185

 gat gaa gag tct cgc ctt tct gct tat tat aac ctg ctc cac tgc cta      748
 Asp Glu Glu Ser Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu
         190                 195                 200

 cgc agg gat tca cat aaa atc gac aat tat ctc aag ctc ctg aag tgc      796
 Arg Arg Asp Ser His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Lys Cys
     205                 210                 215

 cga atc atc cac aac aac aac tgc taagcccaca tccatttcat ctatttctga     850
 Arg Ile Ile His Asn Asn Asn Cys 
 220                 225

 gaaggtcctt aatgatccgt tccattgcaa gcttctttta gttgtatctc ttttgaatcc    910

 atgcttgggt gtaacaggtc tcctcttaaa aaataaaaac tgactcctta gagacatcaa    970

 aaaaagactt cacttaatgg gccgggcgca gtggctcatg nctgtggtcc cggcactttg   1030

 ggaggccgag gcaggcggat caggaggtca gg                                 1062




      <210> 39
      <211> 1697
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (25)..(1578)

      <400> 39
 agcggccgct atcgggaaga agaa   atg act gtg gtg gag gaa gcg gat gat      51
                              Met Thr Val Val Glu Glu Ala Asp Asp
                                1               5

 gac aaa aaa agg ctg ctg cag att att gac aga gat ggg gaa gag gaa       99
 Asp Lys Lys Arg Leu Leu Gln Ile Ile Asp Arg Asp Gly Glu Glu Glu
  10                  15                  20                  25

 gag gaa gag gag gag cca ttg gat gaa agc tca gtg aag aaa atg atc      147
 Glu Glu Glu Glu Glu Pro Leu Asp Glu Ser Ser Val Lys Lys Met Ile
                  30                  35                  40

 ctc aca ttt gaa aag aga tca tat aaa aac caa gaa ttg cgg att aag      195
 Leu Thr Phe Glu Lys Arg Ser Tyr Lys Asn Gln Glu Leu Arg Ile Lys
              45                  50                  55

 ttt cca gac aat cca gag aag ttc atg gaa tcc gag ctg gac cta aat      243
 Phe Pro Asp Asn Pro Glu Lys Phe Met Glu Ser Glu Leu Asp Leu Asn
          60                  65                  70

 gac atc att cag gag atg cac gtg gtg gcc acc atg cca gac ctg tac      291
 Asp Ile Ile Gln Glu Met His Val Val Ala Thr Met Pro Asp Leu Tyr
      75                  80                  85

 cac ctt ctg gtg gag ctg aat gct gta cag tcg ctt ctc ggc ttg ctc      339
 His Leu Leu Val Glu Leu Asn Ala Val Gln Ser Leu Leu Gly Leu Leu
  90                  95                 100                 105

 gga cac gat aat aca gat gtg tcc ata gct gtg gtc gat ttg ctt cag      387
 Gly His Asp Asn Thr Asp Val Ser Ile Ala Val Val Asp Leu Leu Gln
                 110                 115                 120

 gaa tta aca gat ata gac acc ctc cat gag agt gaa gag gga gca gaa      435
 Glu Leu Thr Asp Ile Asp Thr Leu His Glu Ser Glu Glu Gly Ala Glu
             125                 130                 135

 gtg ctc atc gat gct ctg gtg gat ggg cag gtg gta gca ctg ctg gta      483
 Val Leu Ile Asp Ala Leu Val Asp Gly Gln Val Val Ala Leu Leu Val
         140                 145                 150

 cag aat ctg gag cgc ctg gat gag tct gtg aaa gag gag gca gat ggc      531
 Gln Asn Leu Glu Arg Leu Asp Glu Ser Val Lys Glu Glu Ala Asp Gly
     155                 160                 165

 gtc cac aac act ctg gct att gtg gaa aac atg gct gag ttc cgg cct      579
 Val His Asn Thr Leu Ala Ile Val Glu Asn Met Ala Glu Phe Arg Pro
 170                 175                 180                 185

 gag atg tgt aca gag ggt gcc cag cag ggt ctt cta cag tgg ctg ttg      627
 Glu Met Cys Thr Glu Gly Ala Gln Gln Gly Leu Leu Gln Trp Leu Leu
                 190                 195                 200

 aag agg ctg aag gca aag atg cct ttt gat gcc aac aaa ctg tat tgc      675
 Lys Arg Leu Lys Ala Lys Met Pro Phe Asp Ala Asn Lys Leu Tyr Cys
             205                 210                 215

 agt gaa gtg ctg gcc ata ttg ctc cag gac aat gat gaa aac agg gaa      723
 Ser Glu Val Leu Ala Ile Leu Leu Gln Asp Asn Asp Glu Asn Arg Glu
         220                 225                 230

 ttg ctt ggg gag ctg gat gga atc gat gtg ctt ctt cag cag tta tcc      771
 Leu Leu Gly Glu Leu Asp Gly Ile Asp Val Leu Leu Gln Gln Leu Ser
     235                 240                 245

 gtg ttt aaa aga cac aat ccc agc acg gct gag gag cag gag atg atg      819
 Val Phe Lys Arg His Asn Pro Ser Thr Ala Glu Glu Gln Glu Met Met
 250                 255                 260                 265

 gag aat ctg ttt gat tcc ctc tgc tcc tgt cta atg ctt agt tcc aat      867
 Glu Asn Leu Phe Asp Ser Leu Cys Ser Cys Leu Met Leu Ser Ser Asn
                 270                 275                 280

 cgt gag cgc ttc ctg aag ggc gag ggt ctt cag ctg atg aat ctc atg      915
 Arg Glu Arg Phe Leu Lys Gly Glu Gly Leu Gln Leu Met Asn Leu Met
             285                 290                 295

 ctc agg gaa aag aag atc tcc cgg agc agt gcc ctg aaa gtg ctg gac      963
 Leu Arg Glu Lys Lys Ile Ser Arg Ser Ser Ala Leu Lys Val Leu Asp
         300                 305                 310

 cat gcc atg att ggc ccc gaa ggc aca gac aac tgc cat aag ttt gtt     1011
 His Ala Met Ile Gly Pro Glu Gly Thr Asp Asn Cys His Lys Phe Val
     315                 320                 325

 gac att ctt ggc tta cga acc atc ttt ccc ctc ttt atg aaa tct ccc     1059
 Asp Ile Leu Gly Leu Arg Thr Ile Phe Pro Leu Phe Met Lys Ser Pro
 330                 335                 340                 345

 agg aag atc aag aaa gtg gga acc act gag aag gaa cat gaa gag cat     1107
 Arg Lys Ile Lys Lys Val Gly Thr Thr Glu Lys Glu His Glu Glu His
                 350                 355                 360

 gtc tgt tcg atc ctg gct tcc ctc ctg cgg aac ctg aga ggg cag cag     1155
 Val Cys Ser Ile Leu Ala Ser Leu Leu Arg Asn Leu Arg Gly Gln Gln
             365                 370                 375

 cgg acc cgg ctt ctg aat aaa ttc act gaa aat gac agt gag aag gtt     1203
 Arg Thr Arg Leu Leu Asn Lys Phe Thr Glu Asn Asp Ser Glu Lys Val
         380                 385                 390

 gac aga cta atg gag ttg cat ttt aaa tat ctg ggt gca atg cag gtg     1251
 Asp Arg Leu Met Glu Leu His Phe Lys Tyr Leu Gly Ala Met Gln Val
     395                 400                 405

 gcg gac aag aag att gaa ggg gaa aaa cac gac atg gtc cgg cga gga     1299
 Ala Asp Lys Lys Ile Glu Gly Glu Lys His Asp Met Val Arg Arg Gly
 410                 415                 420                 425

 gag atc atc gac aat gac acc gag gag gag ttc tac ctc cgg cgc ctg     1347
 Glu Ile Ile Asp Asn Asp Thr Glu Glu Glu Phe Tyr Leu Arg Arg Leu
                 430                 435                 440

 gat gcg ggg ctc ttt gtt ctc cag cac atc tgc tac atc atg gcc gag     1395
 Asp Ala Gly Leu Phe Val Leu Gln His Ile Cys Tyr Ile Met Ala Glu
             445                 450                 455

 atc tgc aat gcc aat gtc ccc cag att cgc cag agg gtt cac cag atc     1443
 Ile Cys Asn Ala Asn Val Pro Gln Ile Arg Gln Arg Val His Gln Ile
         460                 465                 470

 cta aac atg cga gga agc tcc atc aaa att gtc agg cat atc atc aag     1491
 Leu Asn Met Arg Gly Ser Ser Ile Lys Ile Val Arg His Ile Ile Lys
     475                 480                 485

 gag tat gca gag aac atc ggg gac ggc cgg agc ccg gag ttc cgg gag     1539
 Glu Tyr Ala Glu Asn Ile Gly Asp Gly Arg Ser Pro Glu Phe Arg Glu
 490                 495                 500                 505

 aac gag caa aag cgc atc ctg ggc ttg ctg gag aac ttc tagaggcacc      1588
 Asn Glu Gln Lys Arg Ile Leu Gly Leu Leu Glu Asn Phe 
                 510                 515

 ttggccctgc gcatcatgga ctctctcagc ttccctccca ggatcagttt ctacacaact   1648

 ctgtgtggct tttggacaaa ttaaagctag ttttggtaaa aaaaaaaaa               1697




      <210> 40
      <211> 1823
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (116)..(1366)

      <400> 40
 gctctgttcc tgcccgcgcg gtgttccgca ttctgcaagc ctccggagcg cacgtcggca     60

 gtcggctccc tcgttgaccg aatcaccgac ctctctcccc agctgtattt ccaaa atg     118
                                                              Met
                                                                1

 tcg ctt tct aac aag ctg acg ctg gac aag ctg gac gtt aaa ggg aag      166
 Ser Leu Ser Asn Lys Leu Thr Leu Asp Lys Leu Asp Val Lys Gly Lys
               5                  10                  15

 cgg gtc gtt atg aga gtc gac ttc aat gtt cct atg aag aac aac cag      214
 Arg Val Val Met Arg Val Asp Phe Asn Val Pro Met Lys Asn Asn Gln
          20                  25                  30

 ata aca aac aac cag agg att aag gct gct gtc cca agc atc aaa ttc      262
 Ile Thr Asn Asn Gln Arg Ile Lys Ala Ala Val Pro Ser Ile Lys Phe
      35                  40                  45

 tgc ttg gac aat gga gcc aag tcg gta gtc ctt atg agc cac cta ggc      310
 Cys Leu Asp Asn Gly Ala Lys Ser Val Val Leu Met Ser His Leu Gly
  50                  55                  60                  65

 cgg cct gat ggt gtg ccc atg cct gac aag tac tcc tta gag cca gtt      358
 Arg Pro Asp Gly Val Pro Met Pro Asp Lys Tyr Ser Leu Glu Pro Val
                  70                  75                  80

 gct gta gaa ctc aaa tct ctg ctg ggc aag gat gtt ctg ttc ttg aag      406
 Ala Val Glu Leu Lys Ser Leu Leu Gly Lys Asp Val Leu Phe Leu Lys
              85                  90                  95

 gac tgt gta ggc cca gaa gtg gag aaa gcc tgt gcc aac cca gct gct      454
 Asp Cys Val Gly Pro Glu Val Glu Lys Ala Cys Ala Asn Pro Ala Ala
         100                 105                 110

 ggg tct gtc atc ctg ctg gag aac ctc cgc ttt cat gtg gag gaa gaa      502
 Gly Ser Val Ile Leu Leu Glu Asn Leu Arg Phe His Val Glu Glu Glu
     115                 120                 125

 ggg aag gga aaa gat gct tct ggg aac aag gtt aaa gcc gag cca gcc      550
 Gly Lys Gly Lys Asp Ala Ser Gly Asn Lys Val Lys Ala Glu Pro Ala
 130                 135                 140                 145

 aaa ata gaa gct ttc cga gct tca ctt tcc aag cta ggg gat gtc tat      598
 Lys Ile Glu Ala Phe Arg Ala Ser Leu Ser Lys Leu Gly Asp Val Tyr
                 150                 155                 160

 gtc aat gat gct ttt ggc act gct cac aga gcc cac agc tcc atg gta      646
 Val Asn Asp Ala Phe Gly Thr Ala His Arg Ala His Ser Ser Met Val
             165                 170                 175

 gga gtc aat ctg cca cag aag gct ggt ggg ttt ttg atg aag aag gag      694
 Gly Val Asn Leu Pro Gln Lys Ala Gly Gly Phe Leu Met Lys Lys Glu
         180                 185                 190

 ctg aac tac ttt gca aag gcc ttg gag agc cca gag cga ccc ttc ctg      742
 Leu Asn Tyr Phe Ala Lys Ala Leu Glu Ser Pro Glu Arg Pro Phe Leu
     195                 200                 205

 gcc atc ctg ggc gga gct aaa gtt gca gac aag atc cag ctc atc aat      790
 Ala Ile Leu Gly Gly Ala Lys Val Ala Asp Lys Ile Gln Leu Ile Asn
 210                 215                 220                 225

 aat atg ctg gac aaa gtc aat gag atg att att ggt ggt gga atg gct      838
 Asn Met Leu Asp Lys Val Asn Glu Met Ile Ile Gly Gly Gly Met Ala
                 230                 235                 240

 ttt acc ttc ctt aag gtg ctc aac aac atg gag att ggc act tct ctg      886
 Phe Thr Phe Leu Lys Val Leu Asn Asn Met Glu Ile Gly Thr Ser Leu
             245                 250                 255

 ttt gat gaa gag gga gcc aag att gtc aaa gac cta atg tcc aaa gct      934
 Phe Asp Glu Glu Gly Ala Lys Ile Val Lys Asp Leu Met Ser Lys Ala
         260                 265                 270

 gag aag aat ggt gtg aag att acc ttg cct gtt gac ttt gtc act gct      982
 Glu Lys Asn Gly Val Lys Ile Thr Leu Pro Val Asp Phe Val Thr Ala
     275                 280                 285

 gac aag ttt gat gag aat gcc aag act ggc caa gcc act gtg gct tct     1030
 Asp Lys Phe Asp Glu Asn Ala Lys Thr Gly Gln Ala Thr Val Ala Ser
 290                 295                 300                 305

 ggc ata cct gct ggc tgg atg ggc ttg gac tgt ggt cct gaa agc agc     1078
 Gly Ile Pro Ala Gly Trp Met Gly Leu Asp Cys Gly Pro Glu Ser Ser
                 310                 315                 320

 aag aag tat gct gag gct gtc act cgg gct aag cag att gtg tgg aat     1126
 Lys Lys Tyr Ala Glu Ala Val Thr Arg Ala Lys Gln Ile Val Trp Asn
             325                 330                 335

 ggt cct gtg ggg gta ttt gaa tgg gaa gct ttt gcc cgg gga acc aaa     1174
 Gly Pro Val Gly Val Phe Glu Trp Glu Ala Phe Ala Arg Gly Thr Lys
         340                 345                 350

 gct ctc atg gat gag gtg gtg aaa gcc act tct agg ggc tgc atc acc     1222
 Ala Leu Met Asp Glu Val Val Lys Ala Thr Ser Arg Gly Cys Ile Thr
     355                 360                 365

 atc ata ggt ggt gga gac act gcc act tgc tgt gcc aaa tgg aac acg     1270
 Ile Ile Gly Gly Gly Asp Thr Ala Thr Cys Cys Ala Lys Trp Asn Thr
 370                 375                 380                 385

 gag gat aaa gtc agc cat gtg agc act ggg ggt ggt gcc agt ttg gag     1318
 Glu Asp Lys Val Ser His Val Ser Thr Gly Gly Gly Ala Ser Leu Glu
                 390                 395                 400

 ctc ctg gaa ggt aaa gtc ctt cct ggg gtg gat gct ctc agc aat att     1366
 Leu Leu Glu Gly Lys Val Leu Pro Gly Val Asp Ala Leu Ser Asn Ile 
             405                 410                 415

 tagtactttc ctgcctttta gttcctgtgc acagccccta agtcaactta gcattttctg   1426

 catctccact tggcattagc taaaaccttc catgtcaaga ttcagctagt ggccaagaga   1486

 tgcagtgcca ggaaccctta aacagttgca cagcatctca gctcatcttc actgcaccct   1546

 ggatttgcat acattcttca agatcccatt tgaatttttt agtgactaaa ccattgtgca   1606

 ttctagagtg catatattta tattttgcct gttaaaaaga aagtgagcag tgttagctta   1666

 gttctctttt gatgtaggtt attatgatta gctttgtcac tgtttcacta ctcagcatgg   1726

 aaacaagatg aaattccatt tgtaggtagt gagacaaaat tgatgatcca ttaagtaaac   1786

 aataaaagtg tccattgaaa ccgtgaaaaa aaaaaaa                            1823




      <210> 41
      <211> 1465
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (64)..(1155)

      <400> 41
 agcagaagag ataaaagcaa acaggtctgg gaggcagttc tgttgccact ctctctcctg     60

 tca  atg atg gat ctc aga aat acc cca gcc aaa tct ctg gac aag ttc     108
      Met Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe
        1               5                  10                  15

 att gaa gac tat ctc ttg cca gac acg tgt ttc cgc atg caa atc aac      156
 Ile Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile Asn
                  20                  25                  30

 cat gcc att gac atc atc tgt ggg ttc ctg aag gaa agg tgc ttc cga      204
 His Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe Arg
              35                  40                  45

 ggt agc tcc tac cct gtg tgt gtg tcc aag gtg gta aag ggt ggc tcc      252
 Gly Ser Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly Ser
          50                  55                  60

 tca ggc aag ggc acc acc ctc aga ggc cga tct gac gct gac ctg gtt      300
 Ser Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val
      65                  70                  75

 gtc ttc ctc agt cct ctc acc act ttt cag gat cag tta aat cgc cgg      348
 Val Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg
  80                  85                  90                  95

 gga gag ttc atc cag gaa att agg aga cag ctg gaa gcc tgt caa aga      396
 Gly Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg
                 100                 105                 110

 gag aga gca ttt tcc gtg aag ttt gag gtc cag gct cca cgc tgg ggc      444
 Glu Arg Ala Phe Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Gly
             115                 120                 125

 aac ccc cgt gcg ctc agc ttc gta ctg agt tcg ctc cag ctc ggg gag      492
 Asn Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu
         130                 135                 140

 ggg gtg gag ttc gat gtg ctg cct gcc ttt gat gcc ctg ggt cag ttg      540
 Gly Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu
     145                 150                 155

 act ggc agc tat aaa cct aac ccc caa atc tat gtc aag ctc atc gag      588
 Thr Gly Ser Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu
 160                 165                 170                 175

 gag tgc acc gac ctg cag aaa gag ggc gag ttc tcc acc tgc ttc aca      636
 Glu Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr
                 180                 185                 190

 gaa cta cag aga gac ttc ctg aag cag cgc ccc acc aag ctc aag agc      684
 Glu Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser
             195                 200                 205

 ctc atc cgc cta gtc aag cac tgg tac caa aat tgt aag aag aag ctt      732
 Leu Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu
         210                 215                 220

 ggg aag ctg cca cct cag tat gcc ctg gag ctc ctg acg gtc tat gct      780
 Gly Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala
     225                 230                 235

 tgg gag cga ggg agc atg aaa aca cat ttc aac aca gcc cag gga ttt      828
 Trp Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe
 240                 245                 250                 255

 cgg acg gtc ttg gaa tta gtc ata aac tac cag caa ctc tgc atc tac      876
 Arg Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr
                 260                 265                 270

 tgg aca aag tat tat gac ttt aaa aac ccc att att gaa aag tac ctg      924
 Trp Thr Lys Tyr Tyr Asp Phe Lys Asn Pro Ile Ile Glu Lys Tyr Leu
             275                 280                 285

 aga agg cag ctc acg aaa ccc agg cct gtg atc ctg gac ccg gcg gac      972
 Arg Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp
         290                 295                 300

 cct aca gga aac ttg ggt ggt gga gac cca aag ggt tgg agg cag ctg     1020
 Pro Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu
     305                 310                 315

 gca caa gag gct gag gcc tgg ctg aat tac cca tgc ttt aag aat tgg     1068
 Ala Gln Glu Ala Glu Ala Trp Leu Asn Tyr Pro Cys Phe Lys Asn Trp
 320                 325                 330                 335

 gat ggg tcc cca gtg agc tcc tgg att ctg ctg gtg aga cct cct gct     1116
 Asp Gly Ser Pro Val Ser Ser Trp Ile Leu Leu Val Arg Pro Pro Ala
                 340                 345                 350

 tcc tcc ctg cca ttc atc cct gcc cct ctc cat gaa gct tgagacatat      1165
 Ser Ser Leu Pro Phe Ile Pro Ala Pro Leu His Glu Ala 
             355                 360

 agctggagac cattctttcc aaagaactta cctcttgcca aaggccattt atattcatat   1225

 agtgacaggc tgtgctccat attttacagt cattttggtc acaatcgagg gtttctggaa   1285

 ttttcacatc ccttgtccag aattcattcc cctaagagta ataataaata atctctaaca   1345

 ccatttattg actgtttgct tcggggtcag gttttgtcct agagcccttt aatatgcact   1405

 ttttcattaa atagtcccaa caatcccatg acccagcaag acgagaagaa aaaaaaaaaa   1465




      <210> 42
      <211> 1249
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (83)..(625)

      <400> 42
 tgtgggagca aaaccaacgc ctggctcgga gcagcagcct ctgaggtgtc cctggccagt     60

 gtccttccac ctgtccacaa gc atg ggg aac atc ttc gcc aac ctc ttc aag     112
                          Met Gly Asn Ile Phe Ala Asn Leu Phe Lys
                            1               5                  10

 ggc ctt ttt ggc aaa aaa gaa atg cgc atc ctc atg gtg ggc ctg gat      160
 Gly Leu Phe Gly Lys Lys Glu Met Arg Ile Leu Met Val Gly Leu Asp
                  15                  20                  25

 gct gca ggg aag acc acg atc ctc tac aag ctt aag ctg ggt gag atc      208
 Ala Ala Gly Lys Thr Thr Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile
              30                  35                  40

 gtg acc acc att ccc acc ata ggc ttc aac gtg gaa acc gtg gag tac      256
 Val Thr Thr Ile Pro Thr Ile Gly Phe Asn Val Glu Thr Val Glu Tyr
          45                  50                  55

 aag aac atc agc ttc act gtg tgg gac gtg ggt ggc cag gac aag atc      304
 Lys Asn Ile Ser Phe Thr Val Trp Asp Val Gly Gly Gln Asp Lys Ile
      60                  65                  70

 cgg ccc ctg tgg cgc cac tac ttc cag aac aca caa ggc ctg atc ttc      352
 Arg Pro Leu Trp Arg His Tyr Phe Gln Asn Thr Gln Gly Leu Ile Phe
  75                  80                  85                  90

 gtg gtg gac agc aat gac aga gag cgt gtg aac gag gcc cgt gag gag      400
 Val Val Asp Ser Asn Asp Arg Glu Arg Val Asn Glu Ala Arg Glu Glu
                  95                 100                 105

 ctc atg agg atg ctg gcc gag gac gag ctc cgg gat gct gtc ctc ctg      448
 Leu Met Arg Met Leu Ala Glu Asp Glu Leu Arg Asp Ala Val Leu Leu
             110                 115                 120

 gtg ttc gcc aac aag cag gac ctc ccc aac gcc atg aat gcg gcc gag      496
 Val Phe Ala Asn Lys Gln Asp Leu Pro Asn Ala Met Asn Ala Ala Glu
         125                 130                 135

 atc aca gac aag ctg ggg ctg cac tca cta cgc cac agg aac tgg tac      544
 Ile Thr Asp Lys Leu Gly Leu His Ser Leu Arg His Arg Asn Trp Tyr
     140                 145                 150

 att cag gcc acc tgc gcc acc agc ggc gac ggg ctc tat gaa gga ctg      592
 Ile Gln Ala Thr Cys Ala Thr Ser Gly Asp Gly Leu Tyr Glu Gly Leu
 155                 160                 165                 170

 gac tgg ctg tcc aat cag ctc cgg aac cag aag tgaacgcg acccccctcc      643
 Asp Trp Leu Ser Asn Gln Leu Arg Asn Gln Lys 
                 175                 180

 ctctcactcc tcttgccctc tgctttactc tcatgtggca aacgtgcggc tcgtggtgtg    703

 agtgccagaa gctgcctccg tggtttggtc accgtgtgca tcgcaccgtg ctgtaaatgt    763

 ggcagacgca gcctgcggcc aggcttttta tttaatgtaa atagtttttg tttccaatga    823

 ggcagtttct ggtactccta tgcaatatta ctcagctttt tttattgtaa aaagaaaaat    883

 caactcactg ttcagtgctg agaggggatg taggcccatg ggcacctggc ctccaggagt    943

 cgctgtgttg ggagagccgg ccacgccctt ggctttagag ctgtgttgaa atccattttg   1003

 gtggttggtt tttaacccaa actcagtgca ttttttaaaa tagttaagaa tccaagtcga   1063

 gaacacttga acacacagaa gggagacccc gcctagcata gatttgcagt tacgggctgg   1123

 atgccagtcg ccagcccatc tgtttccctc gggaacatga ggtggtgggg gcgcaacaga   1183

 ctgcgaacaa ttctgcatgg tcacaggaga gaatccccca actcgcttgg ccttggggac   1243

 cctgct                                                              1249




      <210> 43
      <211> 4630
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (3211)..(4230)

      <400> 43
 ggtcggcggc attcggcggc gatggagcgg ccctggggag ctgcggacgg cctctcgcgc     60

 tggccccatg gcctcggcct cctcctcctc ctgcagctgc tgccgccgtc gaccctcagc    120

 caggaccggc tggacgcgcc gccgccgccc gctgcgccgc tgccgcgctg gtctggcccc    180

 atcggggtga gctgggggct gcgggcggcc gcagccgggg gcgcgtttcc ccgcggcggc    240

 cgttggcgtc gcagcgcgcc gggcgaggac gaggagtgcg gccgggtccg ggacttcgtc    300

 gccaagctgg ccaacaacac gcaccagcat gtgtttgatg atctcagagg ctcagtatcc    360

 ttgtcctggg ttggagatag cactggggtc attctagtct tgactacctt ccatgtacca    420

 ctggtaatta tgacttttgg acagtccaag ctatatcgaa gtgaggatta tgggaagaac    480

 tttaaggata ttacagatct catcaataac acctttattc ggactgaatt tggcatggct    540

 attggtcctg agaactctgg aaaggtggtg ttaacagcag aggtgtctgg aggaagtcgt    600

 ggaggaagaa tcttcagatc atcagatttt gcgaagaatt ttgtgcaaac agatctccct    660

 tttcatcctc tcactcagat gatgtatagc cctcagaatt ctgattatct tttagctctc    720

 agcactgaaa atggcctgtg ggtgtccaag aattttgggg gaaaatggga agaaatccac    780

 aaagcagtat gtttggccaa atggggatca gacaacacca tcttctttac aacctatgca    840

 aatggctcct gcaaagctga ccttggggct ctggaattat ggagaacttc agacttggga    900

 aaaagcttca aaactattgg tgtgaaaatc tactcatttg gtcttggggg acgtttcctt    960

 tttgcctctg tgatggctga taaggatacc acaagaagga tccacgtttc aacagatcaa   1020

 ggggacacat ggagcatggc ccagctcccc tccgtgggac aggaacagtt ctattctatt   1080

 ctggcagcaa atgatgacat ggtattcatg catgtagatg aacctggaga cactgggttt   1140

 ggcacaatct ttacctcaga tgatcgaggc attgtctatt ccaagtcttt ggaccgacat   1200

 ctctacacta ccacaggcgg agagacggac tttaccaacg tgacctccct ccgcggcgtc   1260

 tacataacaa gcgtgctctc cgaagataat tctatccaga ccatgatcac ttttgaccaa   1320

 ggaggaaggt ggacgcacct gaggaagcct gaaaacagtg aatgtgatgc tacagcaaaa   1380

 aacaagaatg agtgcagcct tcatattcat gcttccatca gcatctccca gaaactgaat   1440

 gttccaatgg ccccactctc agagccgaag ctcgtaggca tggtcattgc tcatggtagc   1500

 gtgggggatg ccatctcagt gatggttcca gatgtgtaca tctcagatga tgggggttac   1560

 tcctggacaa agatgctgga aggaccccac tattacacca tcctggattc tggaggcatc   1620

 attgtggcca ttgagcacag cagccgtcct atcaatgtga ttaagttctc cacagacgaa   1680

 ggtcaatgct ggcaaaccta cacgttcacc agggacccca tctatttcac tggcctagct   1740

 tcagaacctg gagctaggtc catgaatatc agcatttggg gcttcacaga atctttcctg   1800

 accagccagt gggtctccta caccattgat tttaaagata tccttgaaag gaactgtgaa   1860

 gagaaggact ataccatatg gctggcacac tccacagacc ctgaagatta tgaagatggc   1920

 tgcattttgg gctacaaaga acagtttctg cggctacgca agtcatccat gtgtcagaat   1980

 ggtcgagact atgttgtgac caagcagccc tccatctgcc tctgttccct ggaggacttt   2040

 ctctgtgatt ttggctacta ccgtccagaa aatgactcca agtgtgtgga acagccagaa   2100

 ctgaagggcc acgacctgga gttttgtctg tacggaaaga gaagagaaga acacctaaca   2160

 acaaatgggt accggaaaat tccaggggac aaatgccagg gtggggtaaa tccagttcga   2220

 gaagtaaaag acttgaaaaa gaaatgcaca agcaactttt tgagtccgga aaaacagaat   2280

 tccaagtcaa attctgttcc aattatcctg gccatcgtgg gattgatgct ggtcacagtc   2340

 gtagcaggag tgctcattgt gaagaaatat gtctgtgggg gaaggttcct ggtgcatcga   2400

 tactctgtgc tgcagcagca tgcagaggcc aatggtgtgg atggtgtgga tgctttggac   2460

 acagcctccc acactaataa aagtggttat catgatgact cagatgagga cctcttggaa   2520

 tagctcttca gaggagctgg acccagcatg gatggtggaa ccacagtacc tcttacactc   2580

 cctgtggctc caacttcagg aaataaattt cccattgcga ggacccagct ctgtttctgc   2640

 tgcttccatc aaagccaaaa gacctacact aaagaaatgc agggtggggg tggggaaccc   2700

 tgagcacttt tttacaattg gctctgagaa aaagggagac attttaaatt ctttaacttc   2760

 ttatttctcg tcctgtctct ttgcaaagta tgggcttttg tttttgtttt ttaagggaaa   2820

 cgaaatggaa ttcgaaggga ccttttcact aaccccactt ctgtgtgttc tgcatggtgc   2880

 ctgccccagg gcatctgcca actccagtat cagctctcac agtgtacttg gtaccatccc   2940

 tgggctctgc tggcgagacg aaacagctgt agagatgaaa acaggctgca gaggctggca   3000

 cagctggccg gcttttctcc atctggggac agtcctactc caagaacact gcacaccagc   3060

 tcctcacaca gatcccactt acggcgcgca acgggttcta ggctgcaggc agctcgagga   3120

 cccgcggccc cgccccggct cggcctggca gatagcagag gcagcaggcc gtgccggggg   3180

 ggcatgttgc tgtaaccagt ggcccagggg     atg tta cgg tgg aca gtg cac    3231
                                      Met Leu Arg Trp Thr Val His
                                        1               5

 ctg gag ggc ggg ccc cgc agg gtg aac cat gct gca gtg gct gtc ggg     3279
 Leu Glu Gly Gly Pro Arg Arg Val Asn His Ala Ala Val Ala Val Gly
          10                  15                  20

 cat cgg gta tac tcc ttc ggg ggt tac tgc tct ggt gaa gac tat gag     3327
 His Arg Val Tyr Ser Phe Gly Gly Tyr Cys Ser Gly Glu Asp Tyr Glu
      25                  30                  35

 aca ctg cgt cag ata gat gtg cac att ttc aat gca gtg tcc ttg cgt     3375
 Thr Leu Arg Gln Ile Asp Val His Ile Phe Asn Ala Val Ser Leu Arg
  40                  45                  50                  55

 tgg aca aag ctg ccc ccg gtg aag tct gcc atc cgt ggg caa gct cct     3423
 Trp Thr Lys Leu Pro Pro Val Lys Ser Ala Ile Arg Gly Gln Ala Pro
                  60                  65                  70

 gtg gta ccc tac atg cgc tat gga cac tca acc gtc ctc atc gac gac     3471
 Val Val Pro Tyr Met Arg Tyr Gly His Ser Thr Val Leu Ile Asp Asp
              75                  80                  85

 aca gtc ctc ctt tgg ggc ggg cgg aat gac acc gaa ggg gcc tgc aat     3519
 Thr Val Leu Leu Trp Gly Gly Arg Asn Asp Thr Glu Gly Ala Cys Asn
          90                  95                 100

 gtg ctc tat gcc ttt gac gtc aat acg cac aag tgg ttc aca ccc cga     3567
 Val Leu Tyr Ala Phe Asp Val Asn Thr His Lys Trp Phe Thr Pro Arg
     105                 110                 115

 gtg tca ggg aca gtt cct ggg gcc cgg gat gga cat tca gcc tgt gtc     3615
 Val Ser Gly Thr Val Pro Gly Ala Arg Asp Gly His Ser Ala Cys Val
 120                 125                 130                 135

 cta ggc aag atc atg tac att ttt ggg ggc tac gag cag cag gcg gac     3663
 Leu Gly Lys Ile Met Tyr Ile Phe Gly Gly Tyr Glu Gln Gln Ala Asp
                 140                 145                 150

 tgt ttt tcc aat gac att cac aag cta gat acc agc acc atg aca tgg     3711
 Cys Phe Ser Asn Asp Ile His Lys Leu Asp Thr Ser Thr Met Thr Trp
             155                 160                 165

 act ctt atc tgt aca aag ggc agc cct gca cgc tgg agg gac ttc cac     3759
 Thr Leu Ile Cys Thr Lys Gly Ser Pro Ala Arg Trp Arg Asp Phe His
         170                 175                 180

 tca gcc aca atg ctg gga agt cac atg tat gtc ttt ggg ggc cgt gcc     3807
 Ser Ala Thr Met Leu Gly Ser His Met Tyr Val Phe Gly Gly Arg Ala
     185                 190                 195

 gac cgc ttt ggg cca ttc cat tcc aac aat gag att tac tgc aac cgc     3855
 Asp Arg Phe Gly Pro Phe His Ser Asn Asn Glu Ile Tyr Cys Asn Arg
 200                 205                 210                 215

 att cga gtc ttt gac acc aga act gag gct tgg ctg gac tgt ccc ccg     3903
 Ile Arg Val Phe Asp Thr Arg Thr Glu Ala Trp Leu Asp Cys Pro Pro
                 220                 225                 230

 act cca gtg ctg cct gag ggg cgc cgg agc cac tcg gcc ttt ggc tac     3951
 Thr Pro Val Leu Pro Glu Gly Arg Arg Ser His Ser Ala Phe Gly Tyr
             235                 240                 245

 aat ggg gag ctg tac atc ttt ggt ggt tat aat gca agg ctg aac cgg     3999
 Asn Gly Glu Leu Tyr Ile Phe Gly Gly Tyr Asn Ala Arg Leu Asn Arg
         250                 255                 260

 cac ttc cat gac ctc tgg aag ttt aat cct gtg tcc ttt acc tgg aaa     4047
 His Phe His Asp Leu Trp Lys Phe Asn Pro Val Ser Phe Thr Trp Lys
     265                 270                 275

 aag att gaa ccg aag ggg aag ggg cca tgt ccc cgc cgg cgc cag tgc     4095
 Lys Ile Glu Pro Lys Gly Lys Gly Pro Cys Pro Arg Arg Arg Gln Cys
 280                 285                 290                 295

 tgc tgt att gtt ggt gac aag att gtc ctc ttt ggg ggt acc agt cca     4143
 Cys Cys Ile Val Gly Asp Lys Ile Val Leu Phe Gly Gly Thr Ser Pro
                 300                 305                 310

 tct cct gag gaa ggc ctg gga gat gaa ttt gac ctt ata gat cat tct     4191
 Ser Pro Glu Glu Gly Leu Gly Asp Glu Phe Asp Leu Ile Asp His Ser
             315                 320                 325

 gac tta cac att ttg gac ttt agt aag tat agt tat tcc tgaattgctc      4240
 Asp Leu His Ile Leu Asp Phe Ser Lys Tyr Ser Tyr Ser 
         330                 335                 340

 ctgccatcaa ggtccctgtc tttgggtggt gatatccagg actggatcct ttcctcacct   4300

 ttgaccatct cctttccaca acttctccct taaaggccct agtctgaaga ctctgtgcaa   4360

 actggccgtg attcagtata acctagacca gtcctgtttg cctcatgata tcaggtacag   4420

 cgagtggttg gaagggaggg attgagtgag ggtgagtgag cagcacaggt gtgacctgat   4480

 tagcttggtt tcagtatgga ggagacagac atttttgttc tgctggagat gtagtgtact   4540

 tgtgggaaat gagatggaag gaggtgaatt gacagccatc atataaaact gtcagcagaa   4600

 taaattatat gaaaaaaaaa aaaaagctta                                    4630




      <210> 44
      <211> 979
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (84)..(548)

      <400> 44
 tgttccattt tccgtatctg cttcgggctt ccacctcatt tttttcgctt tgcccattct     60

 gtttcagcca gtcgccaaga atc    atg aaa gtc gcc agt ggc agc acc gcc     110
                              Met Lys Val Ala Ser Gly Ser Thr Ala
                                1               5

 acc gcc gcc gcg ggc ccc agc tgc gcg ctg aag gcc ggc aag aca gcg      158
 Thr Ala Ala Ala Gly Pro Ser Cys Ala Leu Lys Ala Gly Lys Thr Ala
  10                  15                  20                  25

 agc ggt gcg ggc gag gtg gtg cgc tgt ctg tct gag cag agc gtg gcc      206
 Ser Gly Ala Gly Glu Val Val Arg Cys Leu Ser Glu Gln Ser Val Ala
                  30                  35                  40

 atc tcg cgc tgc gcc ggg ggc gcc ggg gcg cgc ctg cct gcc ctg ctg      254
 Ile Ser Arg Cys Ala Gly Gly Ala Gly Ala Arg Leu Pro Ala Leu Leu
              45                  50                  55

 gac gag cag cag gta aac gtg ctg ctc tac gac atg aac ggc tgt tac      302
 Asp Glu Gln Gln Val Asn Val Leu Leu Tyr Asp Met Asn Gly Cys Tyr
          60                  65                  70

 tca cgc ctc aag gag ctg gtg ccc acc ctg ccc cag aac cgc aag gtg      350
 Ser Arg Leu Lys Glu Leu Val Pro Thr Leu Pro Gln Asn Arg Lys Val
      75                  80                  85

 agc aag gtg gag att ctc cag cac gtc atc gac tac atc agg gac ctt      398
 Ser Lys Val Glu Ile Leu Gln His Val Ile Asp Tyr Ile Arg Asp Leu
  90                  95                 100                 105

 cag ttg gag ctg aac tcg gaa tcc gaa gtt gga acc ccc ggg ggc cga      446
 Gln Leu Glu Leu Asn Ser Glu Ser Glu Val Gly Thr Pro Gly Gly Arg
                 110                 115                 120

 ggg ctg ccg gtc cgg gct ccg ctc agc acc ctc aac ggc gag atc agc      494
 Gly Leu Pro Val Arg Ala Pro Leu Ser Thr Leu Asn Gly Glu Ile Ser
             125                 130                 135

 gcc ctg acg gcc gag gcg gca tgc gtt cct gcg gac gat cgc atc ttg      542
 Ala Leu Thr Ala Glu Ala Ala Cys Val Pro Ala Asp Asp Arg Ile Leu
         140                 145                 150

 tgt cgc tgaagcgcct cccccaggga ccggcggacc ccagccatcc agggggcaag       598
 Cys Arg 
     155

 aggaattacg tgctctgtgg gtctccccca acgcgcctcg ccggatctga gggagaacaa    658

 gaccgatcgg cggccactgc gcccttaact gcatccagcc tggggctgag gctgaggcac    718

 tggcgaggaa agggcgctcc tctttgcaca cctactagtc accaaagact ttagggggtg    778

 ggattccact cgtgtgtttc tattttttga aaagcagaca ttttaaaaaa tggtcacgtt    838

 tggtgctttt cagatttctg aggaaattgc tttgtattgt atattacaat gatccccgac    898

 tgaaaatatt gttttacaat agttctgtgg ggctgttttt ttgttattaa acaaataatt    958

 tagatggtga aaaaaaaaaa a                                              979




      <210> 45
      <211> 1747
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (89)..(1102)

      <400> 45
 caggcgctgg gcagtgtgga ggtcgttgga gtcacttccg cgtcaccagc tcctgtgcct     60

 gccagtcggt gcccctcccg ctccagcc   atg ctc tcc gcc ctc gcc cgg cct     112
                                  Met Leu Ser Ala Leu Ala Arg Pro
                                    1               5

 gtc agc gct gct ctc cgc cgc agc ttc agc acc tcg gcc cag aac aat      160
 Val Ser Ala Ala Leu Arg Arg Ser Phe Ser Thr Ser Ala Gln Asn Asn
      10                  15                  20

 gct aaa gta gct gtg cta ggg gcc tct gga ggc atc ggg cag cca ctt      208
 Ala Lys Val Ala Val Leu Gly Ala Ser Gly Gly Ile Gly Gln Pro Leu
  25                  30                  35                  40

 tca ctt ctc ctg aag aac agc ccc ttg gtg agc cgc ctg acc ctc tat      256
 Ser Leu Leu Leu Lys Asn Ser Pro Leu Val Ser Arg Leu Thr Leu Tyr
                  45                  50                  55

 gat atc gcg cac aca ccc gga gtg gcc gca gat ctg agc cac atc gag      304
 Asp Ile Ala His Thr Pro Gly Val Ala Ala Asp Leu Ser His Ile Glu
              60                  65                  70

 acc aaa gcc gct gtg aaa ggc tac ctc gga cct gaa cag ctg cct gac      352
 Thr Lys Ala Ala Val Lys Gly Tyr Leu Gly Pro Glu Gln Leu Pro Asp
          75                  80                  85

 tgc ctg aaa ggt tgt gat gtg gta gtt att ccg gct gga gtc ccc aga      400
 Cys Leu Lys Gly Cys Asp Val Val Val Ile Pro Ala Gly Val Pro Arg
      90                  95                 100

 aag cca ggc atg acc cgg gac gac ctg ttc aac acc aat gcc acg att      448
 Lys Pro Gly Met Thr Arg Asp Asp Leu Phe Asn Thr Asn Ala Thr Ile
 105                 110                 115                 120

 gtg gcc acc ctg acc gct gcc tgt gcc cag cac tgc ccg gaa gcc atg      496
 Val Ala Thr Leu Thr Ala Ala Cys Ala Gln His Cys Pro Glu Ala Met
                 125                 130                 135

 atc tgc gtc att gcc aat ccg gtt aat tcc acc atc ccc atc aca gca      544
 Ile Cys Val Ile Ala Asn Pro Val Asn Ser Thr Ile Pro Ile Thr Ala
             140                 145                 150

 gaa gtt ttc aag aag cat gga gtg tac aac ccc aac aaa atc ttc ggc      592
 Glu Val Phe Lys Lys His Gly Val Tyr Asn Pro Asn Lys Ile Phe Gly
         155                 160                 165

 gtg acg acc ctg gac atc gtc aga gcc aac acc ttt gtt gca gag ctg      640
 Val Thr Thr Leu Asp Ile Val Arg Ala Asn Thr Phe Val Ala Glu Leu
     170                 175                 180

 aag ggt ttg gat cca gct cga gtc aac gtc cct gtc att ggt ggc cat      688
 Lys Gly Leu Asp Pro Ala Arg Val Asn Val Pro Val Ile Gly Gly His
 185                 190                 195                 200

 gct ggg aag acc atc atc ccc ctg atc tct cag tgc acc ccc aag gtg      736
 Ala Gly Lys Thr Ile Ile Pro Leu Ile Ser Gln Cys Thr Pro Lys Val
                 205                 210                 215

 gac ttt ccc cag gac cag ctg aca gca ctc act ggg cgg atc cag gag      784
 Asp Phe Pro Gln Asp Gln Leu Thr Ala Leu Thr Gly Arg Ile Gln Glu
             220                 225                 230

 gcc ggc acg gag gtg gtc aag gct aaa gcc gga gca ggc tct gcc acc      832
 Ala Gly Thr Glu Val Val Lys Ala Lys Ala Gly Ala Gly Ser Ala Thr
         235                 240                 245

 ctc tcc atg gcg tat gcc ggc gcc cgc ttt gtc ttc tcc ctt gtg gat      880
 Leu Ser Met Ala Tyr Ala Gly Ala Arg Phe Val Phe Ser Leu Val Asp
     250                 255                 260

 gca atg aat gga aag gaa ggt gtt gtg gaa tgt tcc ttc gtt aag tca      928
 Ala Met Asn Gly Lys Glu Gly Val Val Glu Cys Ser Phe Val Lys Ser
 265                 270                 275                 280

 cag gaa acg gaa tgt acc tac ttc tcc aca ccg ctg ctg ctt ggg aaa      976
 Gln Glu Thr Glu Cys Thr Tyr Phe Ser Thr Pro Leu Leu Leu Gly Lys
                 285                 290                 295

 aag ggc atc gag aag aac ctg ggc atc ggc aaa gtc tcc tct ttt gag     1024
 Lys Gly Ile Glu Lys Asn Leu Gly Ile Gly Lys Val Ser Ser Phe Glu
             300                 305                 310

 gag aag atg atc tcg gat gcc atc ccc gag ctg aag gcc tcc atc aag     1072
 Glu Lys Met Ile Ser Asp Ala Ile Pro Glu Leu Lys Ala Ser Ile Lys
         315                 320                 325

 aag ggg gaa gat ttc gtg aag acc ctg aag t gagccgctgt gacgggtggc     1123
 Lys Gly Glu Asp Phe Val Lys Thr Leu Lys 
     330                 335

 cagtttcctt aatttatgaa ggcatcatgt cactgcaaag ccgttgcaga taaactttgt   1183

 attttaattt gctttggtga tgattactgt attgacatca tcatgccttc caaattgtgg   1243

 gtggctctgt gggcgcatca ataaaagccg tccttgattt tatttttcaa ggtcccttct   1303

 gtaaatgctg tgctttcttc cctgtgagag ccaactttag agtgtctgct acctcttcat   1363

 taccaatcag aattagatga tgtttaactg ttagactgaa gcgtgacgct ttcatcagta   1423

 gcttcaagaa agtctaaatt gttaatttat ggaattggac acagtattca gtttacccgt   1483

 acatgctcct cccgcccctc ctgttggcac ccttgcatcg cccaggcctg attcctcctg   1543

 ggggtagttc acccccacgg ggtcatagtt cagcggcgaa tgccaggcag ctgttttctg   1603

 gctgagcaaa cagcaccttt ctcattgagc ttcctctact gacctctgtc ccccttggga   1663

 tttcatcttc tgaccgaacc ctgatgttca gtggcagaga cagcccatag ccagaactgt   1723

 gggtagacca gggttggggt gtgc                                          1747




      <210> 46
      <211> 3276
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1502)..(1987)

      <400> 46
 atgaagccgc cgcgcgcccg cggccccgcc caggaagctc cgccactggc agctgggtac     60

 cgattcatca ccgacgtgtt taaagtatcc gtgtgtgtgc ctccaaaaac cgtttgtgga    120

 gacagcagag tgcccgaggc aggaaaccgc tccggcctgg aggcgcccct gcccggactc    180

 gtggactgca gcgctgtccc gctcggaagc cgatcctggg agtccgagcg gggccgcggg    240

 gcctgcgtgg cagccgagtc gagggcttcg ggccgcgggg ctgtggagcg ccccttggcg    300

 ctgggccgcc ggcagccgca tggctggctg tctggggcac tggggaaaca ggcccagagg    360

 gcttcagact cccctaggct tcacaagaac tcccagctgc agggtgtgga aactatgccc    420

 cagacgtccg ttgtcttctc cagcatcctt gggcccagct gtagcggaca ggtgcagcct    480

 ggcatggggg agcgtggagg cggggccggt ggcggctccg gggacctcat cttccaagat    540

 ggacacctca tctctgggtc cctggaggcc ctgatggagc accttgttcc cacggtggac    600

 tattaccccg ataggacgta catcttcacc tttctcctga gctcccgggt ctttatgccc    660

 cctcatgacc tgctggcccg cgtggggcag atctgcgtgg agcagaagca gcagctggaa    720

 gccgggcctg aaaaggccaa gctgaagtct ttctcagcca agatcgtgca gctcctgaag    780

 gagtggaccg aggccttccc ctatgacttc caggatgaga aggccatggc caagctgaaa    840

 gccatcacac accgtgtcac ccagtgtgat gaggagaatg gcacagtgaa gaaggccatt    900

 gcccagatga cacagagcct gttgctgtcc ttggctgccc ggagccagct ccaggaactg    960

 cgagagaagc tccggccacc ggctgtagac aaggggccca tcctcaagac caagccacca   1020

 gccgcccaga aggccatcct gggcgtgtgc tgcgaccccc tgttgctgtc ccagcagctg   1080

 actcacattg agctggacag ggtcagcagc atttaccctg aggacttgat gcagatcgtc   1140

 agccacatgg actccttgga caaccacagg tgccgagggg acctgaccaa gacctacagc   1200

 ctggaggcct atgacaactg gttcaactgc ctgagcatgc tggtggccac tgaggtgtgc   1260

 cggctcctgc tgtcccccgg cagcgccatg ctgaggtcac ctgccacctt ccaggtggtg   1320

 aagaagaaac accggacccg catgttggag ttcttcattg atgtggcccg ggagtgcttc   1380

 aacatcggga acttcaactc catgatggcc atcatctgtg agtgactggg cacccacggt   1440

 ggggctgctg catggcccac ccccccggcc ctgaccctac ctgctgtcct ctgcagctgg   1500

 c    atg aac ctc agt cct gtg gca agg ctg aag aaa act tgg tcc aag    1546
      Met Asn Leu Ser Pro Val Ala Arg Leu Lys Lys Thr Trp Ser Lys
        1               5                  10                  15

 gtc aag aca gcc aag ttt gat gtc ttg gag cat cac atg gac ccg tcc     1594
 Val Lys Thr Ala Lys Phe Asp Val Leu Glu His His Met Asp Pro Ser
                  20                  25                  30

 agc aac ttc tgc aac tac cgt aca gcc ctg cag ggg gcc acg cag agg     1642
 Ser Asn Phe Cys Asn Tyr Arg Thr Ala Leu Gln Gly Ala Thr Gln Arg
              35                  40                  45

 tcc cag atg gcc aac agc agc cgt gaa aag atc gtc atc cct gtg ttc     1690
 Ser Gln Met Ala Asn Ser Ser Arg Glu Lys Ile Val Ile Pro Val Phe
          50                  55                  60

 aac ctc ttc gtt aag gac atc tac ttc ctg cac aaa atc cat acc aac     1738
 Asn Leu Phe Val Lys Asp Ile Tyr Phe Leu His Lys Ile His Thr Asn
      65                  70                  75

 cac ctg ccc aac ggg cac att aac ttt aag aaa ttc tgg gag atc tcc     1786
 His Leu Pro Asn Gly His Ile Asn Phe Lys Lys Phe Trp Glu Ile Ser
  80                  85                  90                  95

 aga cag atc cat gag ttc atg aca tgg aca cag gta gag tgt cct ttc     1834
 Arg Gln Ile His Glu Phe Met Thr Trp Thr Gln Val Glu Cys Pro Phe
                 100                 105                 110

 gag aag gac aag aag att cag agt tac ctg ctc acg gcg ccc atc tac     1882
 Glu Lys Asp Lys Lys Ile Gln Ser Tyr Leu Leu Thr Ala Pro Ile Tyr
             115                 120                 125

 agc gag gaa gct ctc ttc gtc gcc tcc ttt gaa agt gag ggt ccc gag     1930
 Ser Glu Glu Ala Leu Phe Val Ala Ser Phe Glu Ser Glu Gly Pro Glu
         130                 135                 140

 aac cac atg gaa aaa gac agc tgg aag acc ctc agg acc acc ctt ctg     1978
 Asn His Met Glu Lys Asp Ser Trp Lys Thr Leu Arg Thr Thr Leu Leu
     145                 150                 155

 aac aga gcc tgaggcg gatgcagccc gcgacgccag aggaagcacg tgcactaact     2034
 Asn Arg Ala 
 160

 gggtttaaat tttgactgat gtgggttgag atgaggaggc ctcactggtt ggggtccatt   2094

 ttgtatataa cttttatgag aaaaaaatgg taattatttc acgcatcaac ctttggcact   2154

 tacaaagttt tttttgttta ttttaaataa cagggcaggg ccctgctttg gggaggggga   2214

 ggggagagta tcatgggaga tggtatccat gataacatct tattctaatg aaatgtagat   2274

 ttttattttc tacttttgat tattaacatc ttatgaaaaa aatattttaa aaaacccagc   2334

 caaaaccaac gtgagccctg cctgctcgga cgcctttcca gccagtgtct ctgacgtcgg   2394

 ggttagtgcc ttagagggta ctggggtctg gtcttcctgc tctgtggttt gggctgcggt   2454

 gagtcccact ccacctgggc gcctgccctc aggagcctgg gctgcgaggc tccataggag   2514

 ggctggtggc tgggaggtcg cgtccgcaca cttctggaag tgagcctttg agtacgggct   2574

 gtccaaagtt tacattttca ttttcctttc agggatttgt ggggtcaggg aggggcaggg   2634

 ggcacctggc agcatatttt ctgtgacaat gtgtccagca aatcattctt caactacatt   2694

 ttagaaagga ggaaatctaa aataaggtaa gggagggaag catggagttg tcagttttct   2754

 gggctgtgac tgaaagacac actgagctgt gatgaagaaa aatacatggc cgactccagg   2814

 gtggtgacat ttagagctag tcttgaaacc tatcatctac agaggggagg gcagccaaca   2874

 gccctcttcc cacctgggta ggcagcgccc taattggaat tggaaacaga aaattcgcca   2934

 ggccatactg ctggagccca ttcagataaa actgcccaat actgagaggt gttttctaca   2994

 cccagctaga ggagcacact ccattttccc atgtctgact tcgtggtgtg agccctgggc   3054

 cctactgacc atggcgcagg acagctgtcc ttcagaaagc acacggtcaa tccacgtgga   3114

 ccgtctccct cgcaggaact ccgcatcctt gtccctctct gcattcccag tttccgcagg   3174

 agccttgatc aatggggaag cctgggtgag gatgggccag gtcccaattc ccaaagctcc   3234

 tggaagagcc tgaagacatt gggaaaggct gggcctggtg ag                      3276




      <210> 47
      <211> 6170
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (61)..(3072)

      <400> 47
 actttctgat tcatactgac cctggccaat gctgtaactt ctctttctgt ttcctttccc     60
                                                                 
 atg cta ttt cat ccc ctc ctt ccg cac ctc att tct cca ccc ctt gac      108
 Met Leu Phe His Pro Leu Leu Pro His Leu Ile Ser Pro Pro Leu Asp
   1               5                  10                  15

 cct ggg aca cta gcc ggg aac cag agg ctc cag cag gtc atg cac gcg      156
 Pro Gly Thr Leu Ala Gly Asn Gln Arg Leu Gln Gln Val Met His Ala
              20                  25                  30

 gcg gat cct ctg gag atc cag gct gac gtg cac tgg act cat atc cgt      204
 Ala Asp Pro Leu Glu Ile Gln Ala Asp Val His Trp Thr His Ile Arg
          35                  40                  45

 gag aga gag gag gaa gag agg atg gcg ccg gcc tct gag tcc tct gct      252
 Glu Arg Glu Glu Glu Glu Arg Met Ala Pro Ala Ser Glu Ser Ser Ala
      50                  55                  60

 tcc gga gcc cca ttg gat gag aat gac cta gag gaa gat gtg gac tca      300
 Ser Gly Ala Pro Leu Asp Glu Asn Asp Leu Glu Glu Asp Val Asp Ser
  65                  70                  75                  80

 gaa cca gcc gag ata gaa ggg gag gca gca gag gat ggg gac cca ggg      348
 Glu Pro Ala Glu Ile Glu Gly Glu Ala Ala Glu Asp Gly Asp Pro Gly
                  85                  90                  95

 gac act ggt gct gag ctg gat gat gat cag cac tgg tct gac agc ccg      396
 Asp Thr Gly Ala Glu Leu Asp Asp Asp Gln His Trp Ser Asp Ser Pro
             100                 105                 110

 tcg gat gct gac aga gag ctg cgt ttg ccg tgc cca gct gag ggg gaa      444
 Ser Asp Ala Asp Arg Glu Leu Arg Leu Pro Cys Pro Ala Glu Gly Glu
         115                 120                 125

 gca gag ctg gag ctg agg gtg tcg gaa gat gag gag aag ctg ccc gcc      492
 Ala Glu Leu Glu Leu Arg Val Ser Glu Asp Glu Glu Lys Leu Pro Ala
     130                 135                 140

 tca ccg aag cac caa gag aga ggt ccc tcc caa gcc acc agc ccc atc      540
 Ser Pro Lys His Gln Glu Arg Gly Pro Ser Gln Ala Thr Ser Pro Ile
 145                 150                 155                 160

 cgg tct ccc cag gaa tca gct ctt ctg ttc att cca gtc cac agc ccc      588
 Arg Ser Pro Gln Glu Ser Ala Leu Leu Phe Ile Pro Val His Ser Pro
                 165                 170                 175

 tca aca gag ggg ccc caa ctc cca cct gtc cct gcc gcc acc cag gag      636
 Ser Thr Glu Gly Pro Gln Leu Pro Pro Val Pro Ala Ala Thr Gln Glu
             180                 185                 190

 aaa tca cct gag gag cgc ctt ttc cct gag cct ttg ctc ccc aaa gag      684
 Lys Ser Pro Glu Glu Arg Leu Phe Pro Glu Pro Leu Leu Pro Lys Glu
         195                 200                 205

 aag ccc aaa gct gat gcc ccc tcg gat ctg aaa gct gtg cac tct ccc      732
 Lys Pro Lys Ala Asp Ala Pro Ser Asp Leu Lys Ala Val His Ser Pro
     210                 215                 220

 atc cga tca cag cca gtg acc ctg cca gaa gct agg act cct gtc tca      780
 Ile Arg Ser Gln Pro Val Thr Leu Pro Glu Ala Arg Thr Pro Val Ser
 225                 230                 235                 240

 cca ggg agc ccg cag ccc cag cca ccc gtg gcg gcc tcc acg ccc cca      828
 Pro Gly Ser Pro Gln Pro Gln Pro Pro Val Ala Ala Ser Thr Pro Pro
                 245                 250                 255

 ccc agc cca ctc ccc atc tgc tcc cag ccc cag cct tcc acc gag gcc      876
 Pro Ser Pro Leu Pro Ile Cys Ser Gln Pro Gln Pro Ser Thr Glu Ala
             260                 265                 270

 act gtc cca tcc cct acc cag tcc ccc ata cgc ttc cag cct gcc ccg      924
 Thr Val Pro Ser Pro Thr Gln Ser Pro Ile Arg Phe Gln Pro Ala Pro
         275                 280                 285

 gcc aaa aca tcc acc cca ctg gcc cct ctc cct gtc caa agc caa agt      972
 Ala Lys Thr Ser Thr Pro Leu Ala Pro Leu Pro Val Gln Ser Gln Ser
     290                 295                 300

 gac acc aag gac aga ctg ggc agc ccc ctt gct gtg gat gag gcc ctc     1020
 Asp Thr Lys Asp Arg Leu Gly Ser Pro Leu Ala Val Asp Glu Ala Leu
 305                 310                 315                 320

 aga cgg agc gac ctg gtg gag gag ttc tgg atg aag agt gcg gag atc     1068
 Arg Arg Ser Asp Leu Val Glu Glu Phe Trp Met Lys Ser Ala Glu Ile
                 325                 330                 335

 cgc cgc agc ctc ggg ctc aca cct gtg gac cgc agc aag ggg ccc gag     1116
 Arg Arg Ser Leu Gly Leu Thr Pro Val Asp Arg Ser Lys Gly Pro Glu
             340                 345                 350

 ccc agc ttc ccc acg cct gcc ttc agg cca gtg tcc ctc aaa tcc tat     1164
 Pro Ser Phe Pro Thr Pro Ala Phe Arg Pro Val Ser Leu Lys Ser Tyr
         355                 360                 365

 tcc gtt gaa aag tcc ccc cag gat gag gga ctc cac ctt ctc aag cct     1212
 Ser Val Glu Lys Ser Pro Gln Asp Glu Gly Leu His Leu Leu Lys Pro
     370                 375                 380

 ctg tcc atc ccc aaa agg ctg ggc ctg cca aag ccg gaa ggc gag ccg     1260
 Leu Ser Ile Pro Lys Arg Leu Gly Leu Pro Lys Pro Glu Gly Glu Pro
 385                 390                 395                 400

 ttg tcc ctg cca acc ccc cgg tcc ccg tcc gac aga gag cta cgc agc     1308
 Leu Ser Leu Pro Thr Pro Arg Ser Pro Ser Asp Arg Glu Leu Arg Ser
                 405                 410                 415

 gcc cag gag gag cgc agg gag ctg tcc agc agc tct ggc ctg ggc ctg     1356
 Ala Gln Glu Glu Arg Arg Glu Leu Ser Ser Ser Ser Gly Leu Gly Leu
             420                 425                 430

 cac ggg agc tcc tcc aac atg aag aca ctg ggc agc cag agc ttc aac     1404
 His Gly Ser Ser Ser Asn Met Lys Thr Leu Gly Ser Gln Ser Phe Asn
         435                 440                 445

 acc tcg gac tcc gcc atg ctc acg ccc ccc tcc agc ccg ccc cca ccg     1452
 Thr Ser Asp Ser Ala Met Leu Thr Pro Pro Ser Ser Pro Pro Pro Pro
     450                 455                 460

 cca ccc ccg ggc gag gag ccc gcc acc ttg cgg agg aag ctc agg gag     1500
 Pro Pro Pro Gly Glu Glu Pro Ala Thr Leu Arg Arg Lys Leu Arg Glu
 465                 470                 475                 480

 gcc gag ccc aat gcc tcg gtg gtc ccg ccg ccc ttg ccc gcc acc tgg     1548
 Ala Glu Pro Asn Ala Ser Val Val Pro Pro Pro Leu Pro Ala Thr Trp
                 485                 490                 495

 atg cgg ccc ccc cgg gag cct gct cag ccc ccc aga gag gag gtg cgg     1596
 Met Arg Pro Pro Arg Glu Pro Ala Gln Pro Pro Arg Glu Glu Val Arg
             500                 505                 510

 aag tcg ttt gtg gag agt gtg gag gag att ccc ttt gct gat gat gtg     1644
 Lys Ser Phe Val Glu Ser Val Glu Glu Ile Pro Phe Ala Asp Asp Val
         515                 520                 525

 gag gac acc tat gac gac aag act gag gac tca agc ctg cag gag aaa     1692
 Glu Asp Thr Tyr Asp Asp Lys Thr Glu Asp Ser Ser Leu Gln Glu Lys
     530                 535                 540

 ttc ttc acg ccc ccg tcc tgc tgg ccg cgc ccc gag aag cct cgc cac     1740
 Phe Phe Thr Pro Pro Ser Cys Trp Pro Arg Pro Glu Lys Pro Arg His
 545                 550                 555                 560

 ccg ccc ctg gcc aag gag aac ggg agg ctg cct gct ctg gag ggg acg     1788
 Pro Pro Leu Ala Lys Glu Asn Gly Arg Leu Pro Ala Leu Glu Gly Thr
                 565                 570                 575

 ctg cag cca cag aag agg ggg ctg ccc ttg gtg tcc gcg gaa gcc aag     1836
 Leu Gln Pro Gln Lys Arg Gly Leu Pro Leu Val Ser Ala Glu Ala Lys
             580                 585                 590

 gag ttg gcc gag gag cgc atg cga gcc agg gag aag tcc gtg aag agc     1884
 Glu Leu Ala Glu Glu Arg Met Arg Ala Arg Glu Lys Ser Val Lys Ser
         595                 600                 605

 cag gcg ctg cgg gat gcc atg gcc agg cag ctg agc agg atg cag cag     1932
 Gln Ala Leu Arg Asp Ala Met Ala Arg Gln Leu Ser Arg Met Gln Gln
     610                 615                 620

 atg gag ctg gcc tca ggc gcc ccc agg ccc cgc aag gcg tcc tca gca     1980
 Met Glu Leu Ala Ser Gly Ala Pro Arg Pro Arg Lys Ala Ser Ser Ala
 625                 630                 635                 640

 ccc tcc cag ggc aag gag cgc cgg cct gac tcc ccc aca cgc ccc act     2028
 Pro Ser Gln Gly Lys Glu Arg Arg Pro Asp Ser Pro Thr Arg Pro Thr
                 645                 650                 655

 ctc agg ggc tcc gag gag ccc acc ctg aag cat gaa gcc acc agc gag     2076
 Leu Arg Gly Ser Glu Glu Pro Thr Leu Lys His Glu Ala Thr Ser Glu
             660                 665                 670

 gag gtc ctc tcc ccg ccg tcg gac tca ggg ggc cca gat ggc tct ttc     2124
 Glu Val Leu Ser Pro Pro Ser Asp Ser Gly Gly Pro Asp Gly Ser Phe
         675                 680                 685

 act tca tcc gag ggc tcc agt ggg aag agc aag aag agg tcg tca ctc     2172
 Thr Ser Ser Glu Gly Ser Ser Gly Lys Ser Lys Lys Arg Ser Ser Leu
     690                 695                 700

 ttc tcc ccc cgc aga aac aag aag gag aag aag tcc aaa ggc gag ggc     2220
 Phe Ser Pro Arg Arg Asn Lys Lys Glu Lys Lys Ser Lys Gly Glu Gly
 705                 710                 715                 720

 cgg ccc ccg gag aag ccc agc tcc aac ctc ctg gaa gaa gcc gcc gcc     2268
 Arg Pro Pro Glu Lys Pro Ser Ser Asn Leu Leu Glu Glu Ala Ala Ala
                 725                 730                 735

 aaa ccc aag tcc ctg tgg aag tcc gtc ttc tcc ggg tac aag aag gac     2316
 Lys Pro Lys Ser Leu Trp Lys Ser Val Phe Ser Gly Tyr Lys Lys Asp
             740                 745                 750

 aag aag aag aag gcc gac gac aag tcc tgc ccc agc acc ccc tcc agc     2364
 Lys Lys Lys Lys Ala Asp Asp Lys Ser Cys Pro Ser Thr Pro Ser Ser
         755                 760                 765

 ggg gcc acg gtg gac tct gga aag cac agg gtg ctt ccc gtc gta agg     2412
 Gly Ala Thr Val Asp Ser Gly Lys His Arg Val Leu Pro Val Val Arg
     770                 775                 780

 gca gag ctg cag ctc cgg cgc cag ctg agc ttc tcc gag gac tca gac     2460
 Ala Glu Leu Gln Leu Arg Arg Gln Leu Ser Phe Ser Glu Asp Ser Asp
 785                 790                 795                 800

 ctc tcc agc gac gat gtc ctt gag aag tcc tca cag aag tcc cgg cga     2508
 Leu Ser Ser Asp Asp Val Leu Glu Lys Ser Ser Gln Lys Ser Arg Arg
                 805                 810                 815

 gag cca aga acc tac acg gag gag gaa ctg aat gcc aag ctg acc cgg     2556
 Glu Pro Arg Thr Tyr Thr Glu Glu Glu Leu Asn Ala Lys Leu Thr Arg
             820                 825                 830

 cgt gtg caa aag gca gct cgg aga cag gcc aag cag gag gag ctt aag     2604
 Arg Val Gln Lys Ala Ala Arg Arg Gln Ala Lys Gln Glu Glu Leu Lys
         835                 840                 845

 cgg ctg cat cga gcc cag atc atc cag cgg cag ctg cag cag gtg gag     2652
 Arg Leu His Arg Ala Gln Ile Ile Gln Arg Gln Leu Gln Gln Val Glu
     850                 855                 860

 gag agg cag cgg cgg ctg gag gaa agg ggc gtg gct gtg gag aag gcg     2700
 Glu Arg Gln Arg Arg Leu Glu Glu Arg Gly Val Ala Val Glu Lys Ala
 865                 870                 875                 880

 ctc cgg ggc gaa gca ggc atg ggc aag aag gac gac ccc aag ctg atg     2748
 Leu Arg Gly Glu Ala Gly Met Gly Lys Lys Asp Asp Pro Lys Leu Met
                 885                 890                 895

 cag gag tgg ttc aag cta gtg cag gag aag aac gcc atg gtg cgc tac     2796
 Gln Glu Trp Phe Lys Leu Val Gln Glu Lys Asn Ala Met Val Arg Tyr
             900                 905                 910

 gag tcg gag ctg atg atc ttt gcc cgg gag ctg gag ctg gaa gac cgg     2844
 Glu Ser Glu Leu Met Ile Phe Ala Arg Glu Leu Glu Leu Glu Asp Arg
         915                 920                 925

 cag agt cga ctg cag cag gag ctc cgg gaa cgc atg gca gtg gaa gat     2892
 Gln Ser Arg Leu Gln Gln Glu Leu Arg Glu Arg Met Ala Val Glu Asp
     930                 935                 940

 cac ctt aag act gag gag gag ctg tca gaa gag aag cag att ctc aat     2940
 His Leu Lys Thr Glu Glu Glu Leu Ser Glu Glu Lys Gln Ile Leu Asn
 945                 950                 955                 960

 gag atg ctg gag gtg gtg gag cag aga gac tca ctg gtg gcg ctg ctg     2988
 Glu Met Leu Glu Val Val Glu Gln Arg Asp Ser Leu Val Ala Leu Leu
                 965                 970                 975

 gag gag cag cgg ctc cgg gag aga gag gag gac aag gac ctg gag gct     3036
 Glu Glu Gln Arg Leu Arg Glu Arg Glu Glu Asp Lys Asp Leu Glu Ala
             980                 985                 990

 gcc atg ctg tcc aag ggc ttc agc ctt aac tgg tcc tgag ctcccaccca     3086
 Ala Met Leu Ser Lys Gly Phe Ser Leu Asn Trp Ser 
         995                1000

 acgctccatt ttctgttggc atccgcctgg ccaggcagtg gcatccaaac cacccggagc   3146

 cgcgatctga ggaggcctgg cacctccttg gagtttacgc tcagatgccc gtgtgctgct   3206

 tggaaagtgg tcgagtcccg cgtgcagtgg ggagccccag gtgacagtgg ttatctgaga   3266

 cggctccacc tcctgggagg aggcccacct ggacctccca ctcagaggag gagcacggcg   3326

 tgtatggcat gacgcagggg accaccccgc gcgctccctg aggatgtgct ggctgtgccc   3386

 cttttttcca ctggcacatt tggtaagaga gggaagctgc tccccgtcag aaccacagtg   3446

 cgccgtgcga ggggcactgt cttcttcatg ctccctggag caccaccaaa gaaacgtaaa   3506

 caatacccca cgaaagcagg gtcaggggtc agggtgcgat cgagacccag gatgggggcg   3566

 tccagtcatg cccaccccag catcacagga gacatggagg tgcgggcagg ctcctgaatt   3626

 attatgcaaa ttaggaggac gcaggagggg tctgccctcc agccgaacac cacacactgg   3686

 accctaagtg gccaaatgcc tgggccgctt gctggctgtg gcctgaggct tgtgggttgc   3746

 tgcattttgc ttgtagttca caaccatttt gacactggaa aatgctgact ttgggggaca   3806

 ggatgaggcc ctacattcta agcccccagt tggcagacag gcattgtccc tgttccacat   3866

 ttatgtcggg acaggagatg accttttcct ccgtgttttt cctgtgtttg cacgttgaaa   3926

 tgaagctgac aacctggcaa gacgctcagc cgcttcaaac cctttttgtc aattaactta   3986

 ttttttaata cttgaaaaga agtaacttcg tttgtgtatc tttactagag gaactgatca   4046

 cctgcgcccg ggtgcgggag ccacagcggc atctggtgcg tcctacgcga cctggtccgg   4106

 ggctgcccgg tgctcctcac gtgcatctat ttattagcct ttctcttcgt atcactggcc   4166

 tggctggcat cagggagctg cccagaaccc ctgtgtgggt cctcctcaca gctttctgtc   4226

 ccctcctcca cccggtgcct gcctcaccct ggcgctagac catctggacc actcatgtga   4286

 tgagggtgca tttccgttct gttttgggcc aggccaacag cagagctgcc actctcaccc   4346

 tcccagtgag aattccggct ctgcagaact cgcccttgtc tcagtttggg ggccagggca   4406

 tcaccttcct ccgcacatat gttaaagaag gtttcaggat gggccctcat ccacacaggc   4466

 caagagggtg caaggtggga ccctggaatc atgtggctgg tgagaattcc ctcctcccag   4526

 cctaagattc acccagacgg aaacgcgagt gctgcagtgg atgctgggat gcaggctggt   4586

 gcctctcaag cagatcagcg actcccgccc ttccttccga aggcgacggg cacctgcctt   4646

 gtgccggatc ttcatgggga cataaagggc gagccccgaa tcactagctc ctatagccaa   4706

 actgttcctt tctcacggtt ccgcaccagc ctggctgtgt acagctcatc aagccactga   4766

 gctaatcggg gtggggtgct tgtccatcaa agcagtcagc acatagccca gcgaggagcc   4826

 atccggacca gacccgcctg ccaggggcgc tccagccgcc tgccgcctcc gtgggctggg   4886

 gccagctggg agcagaggcc tggcccctcc aaggcgtccc gcagtggagc aggctgagtg   4946

 gctgtgctga ccttgggctt tccatgggaa ccacactgtg cttcaacttg aacattcatc   5006

 ccagctgcaa aggagcaaag aacctgtgtc atccttgtct gtccagaagc tgccatctct   5066

 ctcccatgca catccgggag ataacgccgc tagtggccgc cacagcgctg attctccacc   5126

 tgttctcacg tgaggcaaag gtctcctttt cttttctctt tacttaaaaa aggggagagg   5186

 agggtttcta gattccatct tcaaacccca gtcgtcccat aaaattggac gtgggaaaag   5246

 accttcactg cctgcgtggc ctttcccaga cctctcctcg aatgccacaa aaccggtcca   5306

 gccccggcag agccgccttc ggcccttgta gctcctgctg gccccacaac agggaaacag   5366

 tttgcaaagt ggcttggaag gagtgtggcc tagggatctg ctgtaagtgg ccagacgtag   5426

 caggagagcc cagtgtcacc ttctggtcct ggtcagcctt aacactgtgg catcctccac   5486

 agcacacacg gcagcctgca gtctggaagg tggacccgag cctttgcaga gaggcgccgc   5546

 agagccgcag gcctgcgccc cagccttctg ctcccgactg tgaggacacc cagttctagt   5606

 agagcacttt ttttaaagct cccattttgt aaccactagt ttgcggttga cttgagtact   5666

 ctggtgactt cctgcgtcaa gcgttctcaa gctgtgagaa tgtgcgcagc tccaggcagg   5726

 ttttctctcg gagagttaag tcttcccttg aaggcaggga agcaggatgg atacacatat   5786

 atcacacaca taaaacacca ggtgcgggag cagcccagac tcaaggctga ctaaactgga   5846

 ggctgaatac cgtggaggtc cacatgcagc ttccctggag ggcaggccgg aggcgctccc   5906

 gcccctgggc ttgaggatgc tgcaccccgt gggcttccag gcctgcccag atgatgcctt   5966

 caggcctctg tccctggcgg ccatcctcag gccgattttg accagcaatg atagactctt   6026

 cttaaccctt tcaaaataaa tttttcagtg ggacagaaag gagagttaaa aaacattttt   6086

 ttaaaggtgg taacatctga cccacaaagg gaatgggtct gttttatgca aaataaaagt   6146

 ttttcaaata aaaaaaaaaa aaaa                                          6170




      <210> 48
      <211> 435
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (19)..(360)

      <400> 48
 ggagtcctgc ttatcaca  atg aat gtt ctc ctg ggc agc gtt gtg atc ttt      51
                      Met Asn Val Leu Leu Gly Ser Val Val Ile Phe
                        1               5                  10

 gcc acc ttc gtg act tta tgc aat gca tca tgc tat ttc ata cct aat       99
 Ala Thr Phe Val Thr Leu Cys Asn Ala Ser Cys Tyr Phe Ile Pro Asn
              15                  20                  25

 gag gga gtt cca gga gat tca acc agg aaa tgc atg gat ctc aaa gga      147
 Glu Gly Val Pro Gly Asp Ser Thr Arg Lys Cys Met Asp Leu Lys Gly
          30                  35                  40

 aac aaa cac cca ata aac tcg gag tgg cag act gac aac tgt gag aca      195
 Asn Lys His Pro Ile Asn Ser Glu Trp Gln Thr Asp Asn Cys Glu Thr
      45                  50                  55

 tgc act tgc tac gaa aca gaa att tca tgt tgc acc ctt gtt tct aca      243
 Cys Thr Cys Tyr Glu Thr Glu Ile Ser Cys Cys Thr Leu Val Ser Thr
  60                  65                  70                  75

 cct gtg ggt tat gac aaa gac aac tgc caa aga atc ttc aag aag gag      291
 Pro Val Gly Tyr Asp Lys Asp Asn Cys Gln Arg Ile Phe Lys Lys Glu
                  80                  85                  90

 gac tgc aag tat atc gtg gtg gag aag aag gac cca aaa aag acc tgt      339
 Asp Cys Lys Tyr Ile Val Val Glu Lys Lys Asp Pro Lys Lys Thr Cys
              95                 100                 105

 tct gtc agt gaa tgg ata atc ta atgtgcttct agtaggcaca gggctcccag      392
 Ser Val Ser Glu Trp Ile Ile 
         110

 gccaggcctc attctcctct ggcctctaat agtcaatgaa tgg                      435




      <210> 49
      <211> 903
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (116)..(544)

      <400> 49
 cgatagttct agagcgcgag cgaccgcacc cgtggctttc tctgggcgac cgggtcccag     60

 actcccccca gcacagcaga gcgcttccct gcccacccgc ggaaaccgcc ccagg atg     118
                                                              Met
                                                                1

 cag cac cga ggc ttc ctc ctc ctc acc ctc ctc gcc ctg ctg gcg ctc      166
 Gln His Arg Gly Phe Leu Leu Leu Thr Leu Leu Ala Leu Leu Ala Leu
               5                  10                  15

 acc tcc gcg gtc gcc aaa aag aaa gat aag gtg aag aag ggc ggc ccg      214
 Thr Ser Ala Val Ala Lys Lys Lys Asp Lys Val Lys Lys Gly Gly Pro
          20                  25                  30

 ggg agc gag tgc gct gag tgg gcc tgg ggg ccc tgc acc ccc agc agc      262
 Gly Ser Glu Cys Ala Glu Trp Ala Trp Gly Pro Cys Thr Pro Ser Ser
      35                  40                  45

 aag gat tgc ggc gtg ggt ttc cgc gag ggc acc tgc ggg gcc cag acc      310
 Lys Asp Cys Gly Val Gly Phe Arg Glu Gly Thr Cys Gly Ala Gln Thr
  50                  55                  60                  65

 cag cgc atc cgg tgc agg gtg ccc tgc aac tgg aag aag gag ttt gga      358
 Gln Arg Ile Arg Cys Arg Val Pro Cys Asn Trp Lys Lys Glu Phe Gly
                  70                  75                  80

 gcc gac tgc aag tac aag ttt gag aac tgg ggt gcg tgt gat ggg ggc      406
 Ala Asp Cys Lys Tyr Lys Phe Glu Asn Trp Gly Ala Cys Asp Gly Gly
              85                  90                  95

 aca ggc acc aaa gtc cgc caa ggc acc ctg aag aag gcg cgc tac aat      454
 Thr Gly Thr Lys Val Arg Gln Gly Thr Leu Lys Lys Ala Arg Tyr Asn
         100                 105                 110

 gct cag tgc cag gag acc atc cgc gtc acc aag ccc tgc acc ccc aag      502
 Ala Gln Cys Gln Glu Thr Ile Arg Val Thr Lys Pro Cys Thr Pro Lys
     115                 120                 125

 acc aaa gca aag gcc aaa gcc aag aaa ggg aag gga aag gac tagacgc      551
 Thr Lys Ala Lys Ala Lys Ala Lys Lys Gly Lys Gly Lys Asp 
 130                 135                 140

 caagcctgga tgccaaggag cccctggtgt cacatggggc ctggcccacg ccctccctct    611

 cccaggcccg agatgtgacc caccagtgcc ttctgtctgc tcgttagctt taatcaatca    671

 tgccctgcct tgtccctctc actccccagc cccaccccta agtgcccaaa gtggggaggg    731

 acaagggatt ctgggaagct tgagcctccc ccaaagcaat gtgagtccca gagcccgctt    791

 ttgttcttcc ccacaattcc attactaaga aacacatcaa ataaactgac tttttccccc    851

 caataaaagc tcttcttttt taatatataa aagcccctta aaaaaaaaaa aa            903




      <210> 50
      <211> 2051
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (88)..(1539)

      <400> 50
 gtttccgcgg agcggaccca gcaatgacgg atgatatcac ctcttcttct ctggtgagag     60

 tctgaggata gagacttttt tctcacc    atg aat gtc acc cca gag gtc aag     111
                                  Met Asn Val Thr Pro Glu Val Lys
                                    1               5

 agt cgt ggg atg aag ttt gct gag gag cag ctg cta aag cat gga tgg      159
 Ser Arg Gly Met Lys Phe Ala Glu Glu Gln Leu Leu Lys His Gly Trp
      10                  15                  20

 act caa ggc aaa ggc ctc ggc cgg aag gag aat ggt atc act cag gct      207
 Thr Gln Gly Lys Gly Leu Gly Arg Lys Glu Asn Gly Ile Thr Gln Ala
  25                  30                  35                  40

 ctc agg gtg aca ctg aag caa gac act cat ggg gta gga cat gac cct      255
 Leu Arg Val Thr Leu Lys Gln Asp Thr His Gly Val Gly His Asp Pro
                  45                  50                  55

 gcc aag gag ttc aca aac cac tgg tgg aat gag ctc ttc aac aag act      303
 Ala Lys Glu Phe Thr Asn His Trp Trp Asn Glu Leu Phe Asn Lys Thr
              60                  65                  70

 gcg gcc aac ttg gta gtg gaa act ggg cag gat gga gta cag ata agg      351
 Ala Ala Asn Leu Val Val Glu Thr Gly Gln Asp Gly Val Gln Ile Arg
          75                  80                  85

 agc ctt tct aag gag acc acc cgt tat aat cat ccc aag ccc aac ttg      399
 Ser Leu Ser Lys Glu Thr Thr Arg Tyr Asn His Pro Lys Pro Asn Leu
      90                  95                 100

 ctg tat cag aag ttt gtg aag atg gct aca ttg act tca ggt gga gag      447
 Leu Tyr Gln Lys Phe Val Lys Met Ala Thr Leu Thr Ser Gly Gly Glu
 105                 110                 115                 120

 aag cca aac aaa gac ttg gag agc tgc agt gat gac gac aac cag ggg      495
 Lys Pro Asn Lys Asp Leu Glu Ser Cys Ser Asp Asp Asp Asn Gln Gly
                 125                 130                 135

 tcc aag tcc cca aag att ctg act gat gag atg ctg ctc caa gcc tgt      543
 Ser Lys Ser Pro Lys Ile Leu Thr Asp Glu Met Leu Leu Gln Ala Cys
             140                 145                 150

 gag ggg cga aca gca cac aag gct gcc cgt ctt ggg atc aca atg aag      591
 Glu Gly Arg Thr Ala His Lys Ala Ala Arg Leu Gly Ile Thr Met Lys
         155                 160                 165

 gcc aag ctt gct cgc cta gag gcc cag gag cag gcc ttc ctg gct cgt      639
 Ala Lys Leu Ala Arg Leu Glu Ala Gln Glu Gln Ala Phe Leu Ala Arg
     170                 175                 180

 ctc aaa ggc cag gac cct ggg gcc cct caa ctg cag tca gag agc aag      687
 Leu Lys Gly Gln Asp Pro Gly Ala Pro Gln Leu Gln Ser Glu Ser Lys
 185                 190                 195                 200

 ccc ccc aaa aaa aag aaa aag aaa agg agg cag aaa gag gag gaa gaa      735
 Pro Pro Lys Lys Lys Lys Lys Lys Arg Arg Gln Lys Glu Glu Glu Glu
                 205                 210                 215

 gct aca gca tct gaa agg aat gat gca gat gag aag cac cca gaa cat      783
 Ala Thr Ala Ser Glu Arg Asn Asp Ala Asp Glu Lys His Pro Glu His
             220                 225                 230

 gct gag cag aac atc aga aaa agc aaa aaa aag aaa aag aaa agg agg      831
 Ala Glu Gln Asn Ile Arg Lys Ser Lys Lys Lys Lys Lys Lys Arg Arg
         235                 240                 245

 cag aaa gag gag gaa gaa gct aca gca tct gaa agg aat gat gca gat      879
 Gln Lys Glu Glu Glu Glu Ala Thr Ala Ser Glu Arg Asn Asp Ala Asp
     250                 255                 260

 gag aag cac cca gaa cat gct gag cag aac atc aga aaa agc aag aag      927
 Glu Lys His Pro Glu His Ala Glu Gln Asn Ile Arg Lys Ser Lys Lys
 265                 270                 275                 280

 aag aaa agg cga cat caa gaa gga aag gtc tca gat gaa aga gag ggt      975
 Lys Lys Arg Arg His Gln Glu Gly Lys Val Ser Asp Glu Arg Glu Gly
                 285                 290                 295

 aca act aaa ggg aat gag aag gag gac gct gca gga aca agt ggg ctt     1023
 Thr Thr Lys Gly Asn Glu Lys Glu Asp Ala Ala Gly Thr Ser Gly Leu
             300                 305                 310

 ggg gaa ttg aat agc aga gag caa acc aat cag tcc ctc agg aaa ggg     1071
 Gly Glu Leu Asn Ser Arg Glu Gln Thr Asn Gln Ser Leu Arg Lys Gly
         315                 320                 325

 aag aaa aag aag agg tgg cac cat gaa gag gag aag atg ggg gtc ttg     1119
 Lys Lys Lys Lys Arg Trp His His Glu Glu Glu Lys Met Gly Val Leu
     330                 335                 340

 gag gaa gga gga aaa ggc aag gag gct gca ggc agt gtc agg aca gag     1167
 Glu Glu Gly Gly Lys Gly Lys Glu Ala Ala Gly Ser Val Arg Thr Glu
 345                 350                 355                 360

 gag gta gag agc agg gca tat gct gac cca tgc agc cga aga aag aag     1215
 Glu Val Glu Ser Arg Ala Tyr Ala Asp Pro Cys Ser Arg Arg Lys Lys
                 365                 370                 375

 agg cag caa cag gag gag gag gac ttg aac cta gaa gat aga ggt gag     1263
 Arg Gln Gln Gln Glu Glu Glu Asp Leu Asn Leu Glu Asp Arg Gly Glu
             380                 385                 390

 gaa act gtt tta ggt ggt gga acc agg gaa gca gag agc aga gca tgc     1311
 Glu Thr Val Leu Gly Gly Gly Thr Arg Glu Ala Glu Ser Arg Ala Cys
         395                 400                 405

 agt gat gga aga agc agg aaa agc aag aag aaa aga cag cag cat caa     1359
 Ser Asp Gly Arg Ser Arg Lys Ser Lys Lys Lys Arg Gln Gln His Gln
     410                 415                 420

 gag gag gag gac atc ttg gat gta agg gat gag aag gat agc ggg gct     1407
 Glu Glu Glu Asp Ile Leu Asp Val Arg Asp Glu Lys Asp Ser Gly Ala
 425                 430                 435                 440

 agg gaa gca gag agc aga gca cac act ggc tca agc agc aga ggt aag     1455
 Arg Glu Ala Glu Ser Arg Ala His Thr Gly Ser Ser Ser Arg Gly Lys
                 445                 450                 455

 agg aag agg cag cag cat ccc aag aag gaa aga gct gga gtc agc act     1503
 Arg Lys Arg Gln Gln His Pro Lys Lys Glu Arg Ala Gly Val Ser Thr
             460                 465                 470

 gtc cag aaa gcc aaa aag aaa cag aag aag aga gac taaa ggtctggtaa     1553
 Val Gln Lys Ala Lys Lys Lys Gln Lys Lys Arg Asp 
         475                 480

 aggtagggct caattgattg attttcagga gttgaagcct caaagaccag ggttgatgca   1613

 ggtctgcagg tcttctgcac ccccctcaat gaggagtccc tcccagaaag gaaactgatc   1673

 tctgggatgt cagctgctga gaggagcaag cggtagtacc accccttagt tgagggagtc   1733

 agcacagtcc tttctgcagc ttctaaccca ggaccatgaa ctcaggtgcc tagagaagcc   1793

 aggcagctaa aggacaagga atgctggggg ctgtgggaac aggaatgcag ataccctttg   1853

 aaggagcatt cctgctaaaa gaagctgaaa atgtagacct atgtgaagtg ctctgatttc   1913

 taaatattgt gaaggttaag aaaaacataa atttaggtct atgggctaga tttagcccac   1973

 agttgccagt ttctagcgct accaaatgaa tgaataaaca tgagcttgcg ctcctagcct   2033

 agagataaaa aaaaaaaa                                                 2051




      <210> 51
      <211> 1253
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (30)..(1016)

      <400> 51
 ccagcggagt tgtgggggcc ggaggcgcc  atg gga gcc act ggc gac gcc gag      53
                                  Met Gly Ala Thr Gly Asp Ala Glu
                                    1               5

 cag ccg cgg gga ccc agc ggg gcc gag agg ggc ggc ttg gag ctg ggg      101
 Gln Pro Arg Gly Pro Ser Gly Ala Glu Arg Gly Gly Leu Glu Leu Gly
      10                  15                  20

 gat gcg ggc gca gcg ggg cag ctg gtt ctt acg aac cct tgg aac ata      149
 Asp Ala Gly Ala Ala Gly Gln Leu Val Leu Thr Asn Pro Trp Asn Ile
  25                  30                  35                  40

 atg ata aag cac cgg cag gtg cag cgg agg ggc cgc cgc tca cag atg      197
 Met Ile Lys His Arg Gln Val Gln Arg Arg Gly Arg Arg Ser Gln Met
                  45                  50                  55

 aca aca agt ttc aca gat cct gcc atc tcc atg gat ctc ctc cga gct      245
 Thr Thr Ser Phe Thr Asp Pro Ala Ile Ser Met Asp Leu Leu Arg Ala
              60                  65                  70

 gtc ctg cag ccc agc atc aac gag gag atc cag act gtc ttc aac aag      293
 Val Leu Gln Pro Ser Ile Asn Glu Glu Ile Gln Thr Val Phe Asn Lys
          75                  80                  85

 tac atg aag ttc ttc cag aag gca gca ctg aac gtg cga gac aat gtt      341
 Tyr Met Lys Phe Phe Gln Lys Ala Ala Leu Asn Val Arg Asp Asn Val
      90                  95                 100

 ggg gag gag gtg gac gca gag cag ctg atc cag gaa gcc tgt cgg agc      389
 Gly Glu Glu Val Asp Ala Glu Gln Leu Ile Gln Glu Ala Cys Arg Ser
 105                 110                 115                 120

 tgc ctg gag cag gct aaa ctg ctc ttt tca gat gga gaa aaa gta ata      437
 Cys Leu Glu Gln Ala Lys Leu Leu Phe Ser Asp Gly Glu Lys Val Ile
                 125                 130                 135

 ccc aga ttg acc cat gag ctt cca gga ata aag cgt ggc cgt cag gca      485
 Pro Arg Leu Thr His Glu Leu Pro Gly Ile Lys Arg Gly Arg Gln Ala
             140                 145                 150

 gaa gaa gaa tgt gcc cat cga gga agc ccc ctt cct aaa aag agg aaa      533
 Glu Glu Glu Cys Ala His Arg Gly Ser Pro Leu Pro Lys Lys Arg Lys
         155                 160                 165

 gga cgg cct cct gga cac atc ctg tca agc gac cgg gca gcc gcc ggc      581
 Gly Arg Pro Pro Gly His Ile Leu Ser Ser Asp Arg Ala Ala Ala Gly
     170                 175                 180

 atg gta tgg aaa cca aaa tcc tgt gaa cca att cgc cgg gaa ggc ccc      629
 Met Val Trp Lys Pro Lys Ser Cys Glu Pro Ile Arg Arg Glu Gly Pro
 185                 190                 195                 200

 aag tgg gac cca gct cgc ctg aat gaa tct acc acc ttt gtg ttg gga      677
 Lys Trp Asp Pro Ala Arg Leu Asn Glu Ser Thr Thr Phe Val Leu Gly
                 205                 210                 215

 tct cga gcc aac aaa gcc ctg ggg atg ggg ggc acc aga gga aga atc      725
 Ser Arg Ala Asn Lys Ala Leu Gly Met Gly Gly Thr Arg Gly Arg Ile
             220                 225                 230

 tac atc aag cac cca cac ctc ttt aag tat gca gct gac ccc cag gat      773
 Tyr Ile Lys His Pro His Leu Phe Lys Tyr Ala Ala Asp Pro Gln Asp
         235                 240                 245

 aag cac tgg ctg gct gag cag cat cac atg cgg gca aca ggg ggc aag      821
 Lys His Trp Leu Ala Glu Gln His His Met Arg Ala Thr Gly Gly Lys
     250                 255                 260

 atg gcc tac ctc ctc atc gag gag gac atc cgg gac ctt gcg gcc agt      869
 Met Ala Tyr Leu Leu Ile Glu Glu Asp Ile Arg Asp Leu Ala Ala Ser
 265                 270                 275                 280

 gat gat tac aga gga tgc ctg gat ctg aag cta gag gaa ttg aaa tcc      917
 Asp Asp Tyr Arg Gly Cys Leu Asp Leu Lys Leu Glu Glu Leu Lys Ser
                 285                 290                 295

 ttt gtc cta ccc tcc tgg atg gtg gag aag atg aga aag tat atg gag      965
 Phe Val Leu Pro Ser Trp Met Val Glu Lys Met Arg Lys Tyr Met Glu
             300                 305                 310

 aca cta cgg aca gag aat gag cat cgt gct gtt gaa gca cct cca cag     1013
 Thr Leu Arg Thr Glu Asn Glu His Arg Ala Val Glu Ala Pro Pro Gln
         315                 320                 325

 acc tgag gccgggtccc ctggccacac ttggcagccc tcctccaaag cccttttcct     1070
 Thr 


 cacgtggttg aggccaccgc tgggactgct cctagatgga tttcagcggc attaagctgt   1130

 gcctgagcga gtttgtagtg actcactgca cagcaccccc agactagcat gtggttttat   1190

 atttgtaaag ttattgggat aagaaacaat taaacagttt gtagtaaacc caaaaaaaaa   1250

 aaa                                                                 1253




      <210> 52
      <211> 2811
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (502)..(2775)

      <400> 52
 gatcctccta cctcactctc ccaagttact gggactatag gagcatgcca ccacacctgg     60

 ctactttttg tattttttgg tagagactgg gtctcactgt attgcccaaa ctggttttga    120

 actcttgggc acaagcagtc tgaccacctt ggcctcctaa agtgctagga tttcaggcgt    180

 gagctactgt gcccaatcct gatttccttt taattcaaac agaaatggga gactaagttt    240

 agtttgccac ttacaggatc tagctggtaa tacagtttcc agagatcatt tattttcaaa    300

 aacttctgga ttcgttaata aagttttatt gagtgattat tacatgcaaa gcacaagtct    360

 gcaaaacagt tcctttgaat gcttttcccc tagggtggta aattaataaa cattaagtac    420

 ttattttata ccagttattg attcctgtcc ttcccttggc attttctctt ggcagcctcc    480

 cgagcacaac aaggagaggt g  atg agg ttg gca tgt cgt ttg gat ccc aaa     531
                          Met Arg Leu Ala Cys Arg Leu Asp Pro Lys
                            1               5                  10

 act agc ttc cag atg gct ggg gag tgg cta aag tat caa cta tca act      579
 Thr Ser Phe Gln Met Ala Gly Glu Trp Leu Lys Tyr Gln Leu Ser Thr
                  15                  20                  25

 ttt ctt gat gct ggt tct gtg aat tct tgt tct gca gtt gga act gga      627
 Phe Leu Asp Ala Gly Ser Val Asn Ser Cys Ser Ala Val Gly Thr Gly
              30                  35                  40

 gaa gga agc ctc tgt tcc gtc ttc tca cct tca ttc gtg cag tgg gaa      675
 Glu Gly Ser Leu Cys Ser Val Phe Ser Pro Ser Phe Val Gln Trp Glu
          45                  50                  55

 gcc atg act ctt ttt ttg gaa agt gtt atc acc cag atg ttt cga aca      723
 Ala Met Thr Leu Phe Leu Glu Ser Val Ile Thr Gln Met Phe Arg Thr
      60                  65                  70

 cta aat aga gaa gaa att cct gtt aat gat gga ata gag cta ttg cag      771
 Leu Asn Arg Glu Glu Ile Pro Val Asn Asp Gly Ile Glu Leu Leu Gln
  75                  80                  85                  90

 atg gtt ctg aac ttt gat acc aag gat ccc ctc atc ctg tcc tgc gtc      819
 Met Val Leu Asn Phe Asp Thr Lys Asp Pro Leu Ile Leu Ser Cys Val
                  95                 100                 105

 ctt act aat gtc tct gca ctc ttt cca ttt gtc acc tac aga cca gag      867
 Leu Thr Asn Val Ser Ala Leu Phe Pro Phe Val Thr Tyr Arg Pro Glu
             110                 115                 120

 ttc ctg ccc cag gtc ttc tct aag cta ttt tca tct gtc act ttt gaa      915
 Phe Leu Pro Gln Val Phe Ser Lys Leu Phe Ser Ser Val Thr Phe Glu
         125                 130                 135

 act gtt gaa gaa agt aag gcc ccc aga acc cgg gca gtg agg aat gtg      963
 Thr Val Glu Glu Ser Lys Ala Pro Arg Thr Arg Ala Val Arg Asn Val
     140                 145                 150

 agg agg cat gct tgt tcc tcc atc atc aag atg tgt cgt gac tac ccc     1011
 Arg Arg His Ala Cys Ser Ser Ile Ile Lys Met Cys Arg Asp Tyr Pro
 155                 160                 165                 170

 cag ctt gtg ctg ccc aat ttt gac atg ctt tat aac cat gtg aag caa     1059
 Gln Leu Val Leu Pro Asn Phe Asp Met Leu Tyr Asn His Val Lys Gln
                 175                 180                 185

 ctc ctc tcc aat gag cta ctc ctg aca caa atg gag aag tgt gcc ctc     1107
 Leu Leu Ser Asn Glu Leu Leu Leu Thr Gln Met Glu Lys Cys Ala Leu
             190                 195                 200

 atg gaa gcc ctg gtt ctc att agc aac caa ttt aag aac tac gag cgt     1155
 Met Glu Ala Leu Val Leu Ile Ser Asn Gln Phe Lys Asn Tyr Glu Arg
         205                 210                 215

 cag aag gtg ttc cta gag gag ctg atg gca cca gtg gcc agc atc tgg     1203
 Gln Lys Val Phe Leu Glu Glu Leu Met Ala Pro Val Ala Ser Ile Trp
     220                 225                 230

 ctt tct caa gac atg cac aga gtg ctg tca gat gtt gat gct ttc att     1251
 Leu Ser Gln Asp Met His Arg Val Leu Ser Asp Val Asp Ala Phe Ile
 235                 240                 245                 250

 gcg tat gtg ggt aca gat cag aag agc tgt gac cca ggc ctg gag gat     1299
 Ala Tyr Val Gly Thr Asp Gln Lys Ser Cys Asp Pro Gly Leu Glu Asp
                 255                 260                 265

 ccg tgt ggc tta aac cgt gca cga atg agc ttt tgt gta tac agc att     1347
 Pro Cys Gly Leu Asn Arg Ala Arg Met Ser Phe Cys Val Tyr Ser Ile
             270                 275                 280

 ctg ggt gtg gtg aaa cga act tgc tgg ccc act gac cta gaa gag gcc     1395
 Leu Gly Val Val Lys Arg Thr Cys Trp Pro Thr Asp Leu Glu Glu Ala
         285                 290                 295

 aaa gct ggg gga ttt gtg gtg ggt tat aca tcc agt gga aat cca atc     1443
 Lys Ala Gly Gly Phe Val Val Gly Tyr Thr Ser Ser Gly Asn Pro Ile
     300                 305                 310

 ttc cgt aac ccc tgc aca gag cag att ctg aaa ctt ctt gac aat ttg     1491
 Phe Arg Asn Pro Cys Thr Glu Gln Ile Leu Lys Leu Leu Asp Asn Leu
 315                 320                 325                 330

 ctt gcg ctt ata aga acc cac aat aca tta tat gca cca gaa atg cta     1539
 Leu Ala Leu Ile Arg Thr His Asn Thr Leu Tyr Ala Pro Glu Met Leu
                 335                 340                 345

 gcc aaa atg gca gag cct ttc acc aag gct ctg gat atg ctt gac gcg     1587
 Ala Lys Met Ala Glu Pro Phe Thr Lys Ala Leu Asp Met Leu Asp Ala
             350                 355                 360

 gaa aaa tct gct ata tta gga tta cct caa cct ctc ttg gaa ctc aat     1635
 Glu Lys Ser Ala Ile Leu Gly Leu Pro Gln Pro Leu Leu Glu Leu Asn
         365                 370                 375

 gac tct cct gtc ttc aaa acc gtc ttg gaa aga atg cag cgt ttc ttc     1683
 Asp Ser Pro Val Phe Lys Thr Val Leu Glu Arg Met Gln Arg Phe Phe
     380                 385                 390

 tct acc ctc tat gaa aac tgt ttt cat atc cta ggg aag gca ggc cct     1731
 Ser Thr Leu Tyr Glu Asn Cys Phe His Ile Leu Gly Lys Ala Gly Pro
 395                 400                 405                 410

 tcc atg cag caa gac ttc tat act gtg gag gac ctt gct acc cag ctt     1779
 Ser Met Gln Gln Asp Phe Tyr Thr Val Glu Asp Leu Ala Thr Gln Leu
                 415                 420                 425

 ctc agc tca gcc ttt gtc aac ttg aac aat att cct gac tac cga ctc     1827
 Leu Ser Ser Ala Phe Val Asn Leu Asn Asn Ile Pro Asp Tyr Arg Leu
             430                 435                 440

 aga ccc atg ctt cgt gtc ttt gta aag cct ctg gtg ctc ttc tgt ccc     1875
 Arg Pro Met Leu Arg Val Phe Val Lys Pro Leu Val Leu Phe Cys Pro
         445                 450                 455

 cca gag cac tat gaa gcc ctg gta tcc ccc atc ctc gga cct ctt ttc     1923
 Pro Glu His Tyr Glu Ala Leu Val Ser Pro Ile Leu Gly Pro Leu Phe
     460                 465                 470

 acc tac ctc cat atg agg ctt tct cag aaa tgg caa gtt atc aac caa     1971
 Thr Tyr Leu His Met Arg Leu Ser Gln Lys Trp Gln Val Ile Asn Gln
 475                 480                 485                 490

 agg agc ctg ctg tgt gga gaa gat gag gct gca gat gaa aac cca gag     2019
 Arg Ser Leu Leu Cys Gly Glu Asp Glu Ala Ala Asp Glu Asn Pro Glu
                 495                 500                 505

 tct caa gag atg ctg gag gag caa ctg gtg agg atg tta acc cga gaa     2067
 Ser Gln Glu Met Leu Glu Glu Gln Leu Val Arg Met Leu Thr Arg Glu
             510                 515                 520

 gtc atg gac cta atc acg gtt tgc tgt gtt tca aag aag ggt gct gac     2115
 Val Met Asp Leu Ile Thr Val Cys Cys Val Ser Lys Lys Gly Ala Asp
         525                 530                 535

 cac agt agt gct ccc cca gca gat gga gac gat gaa gaa atg atg gcc     2163
 His Ser Ser Ala Pro Pro Ala Asp Gly Asp Asp Glu Glu Met Met Ala
     540                 545                 550

 aca gag gtc acc ccc tca gct atg gca gag ctt aca gac ctg ggc aaa     2211
 Thr Glu Val Thr Pro Ser Ala Met Ala Glu Leu Thr Asp Leu Gly Lys
 555                 560                 565                 570

 tgt ctg atg aag cat gag gat gtt tgt aca gcg cta tta att aca gcc     2259
 Cys Leu Met Lys His Glu Asp Val Cys Thr Ala Leu Leu Ile Thr Ala
                 575                 580                 585

 ttc aat tcc ctg gcc tgg aaa gat act ctg tcc tgc cag agg aca acc     2307
 Phe Asn Ser Leu Ala Trp Lys Asp Thr Leu Ser Cys Gln Arg Thr Thr
             590                 595                 600

 tca cag ctc tgc tgg cct ctc ctc aaa caa gtg ctg tca ggg aca ctg     2355
 Ser Gln Leu Cys Trp Pro Leu Leu Lys Gln Val Leu Ser Gly Thr Leu
         605                 610                 615

 ctc gca gat gca gtt acg tgg ctt ttc acc agt gtg ctg aaa ggc tta     2403
 Leu Ala Asp Ala Val Thr Trp Leu Phe Thr Ser Val Leu Lys Gly Leu
     620                 625                 630

 cag atg cac ggg cag cac gac ggg tgc atg gct tcc ctg gtc cat ctg     2451
 Gln Met His Gly Gln His Asp Gly Cys Met Ala Ser Leu Val His Leu
 635                 640                 645                 650

 gcc ttc cag ata tac gag gca ctg cgc ccc agg tac ctg gag ata aga     2499
 Ala Phe Gln Ile Tyr Glu Ala Leu Arg Pro Arg Tyr Leu Glu Ile Arg
                 655                 660                 665

 gct gta atg gag caa atc cct gaa ata cag aag gac tca ctg gac cag     2547
 Ala Val Met Glu Gln Ile Pro Glu Ile Gln Lys Asp Ser Leu Asp Gln
             670                 675                 680

 ttt gac tgc aag ctt tta aac ccc tcc ctg cag aaa gtg gct gac aag     2595
 Phe Asp Cys Lys Leu Leu Asn Pro Ser Leu Gln Lys Val Ala Asp Lys
         685                 690                 695

 cgc cga aag gac caa ttc aaa cgc ctc att gct ggt tgc att ggg aaa     2643
 Arg Arg Lys Asp Gln Phe Lys Arg Leu Ile Ala Gly Cys Ile Gly Lys
     700                 705                 710

 ccc ttg gga gag cag ttc cga aaa gaa gtt cac att aag aat ctt ccc     2691
 Pro Leu Gly Glu Gln Phe Arg Lys Glu Val His Ile Lys Asn Leu Pro
 715                 720                 725                 730

 tca ctt ttc aaa aaa aca aag cca atg ctg gag acg gag gtg ctg gac     2739
 Ser Leu Phe Lys Lys Thr Lys Pro Met Leu Glu Thr Glu Val Leu Asp
                 735                 740                 745

 aat gat ggg ggt ggc ctg gcc acc atc ttt gaa ccc tgaa tcaagctttt     2789
 Asn Asp Gly Gly Gly Leu Ala Thr Ile Phe Glu Pro 
             750                 755

 gggcatcctt aaaaaaaaaa aa                                            2811




      <210> 53
      <211> 3842
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (172)..(3573)

      <400> 53
 taagcttgcg gccgcccgcc cgctgggagc cacggcttag cagccgaccg ctagctgcgc     60

 cgccgcccgg ggaccggcat gaggaccgcc gcggggggac gtctgcggcc cgcgtcggcg    120

 ctggggacaa agaagccatg cagtgacacc cgctaagact tgttggtagc c atg tcg     177
                                                          Met Ser
                                                            1

 gag ccc cac agg gtc cag ttc acc tct ctc cca ggt tcc ctg aat cct      225
 Glu Pro His Arg Val Gln Phe Thr Ser Leu Pro Gly Ser Leu Asn Pro
           5                  10                  15

 gcg ttt ttg aag aag tcc cgg aag gag gag gct ggg gca gga gaa cag      273
 Ala Phe Leu Lys Lys Ser Arg Lys Glu Glu Ala Gly Ala Gly Glu Gln
      20                  25                  30

 cat cag gac tgt gag ccg gct gca gca gct gtt cgg att aca ctc acc      321
 His Gln Asp Cys Glu Pro Ala Ala Ala Ala Val Arg Ile Thr Leu Thr
  35                  40                  45                  50

 ctc ttt gaa cca gat cac aaa cgc tgc cca gag ttc ttc tac cca gag      369
 Leu Phe Glu Pro Asp His Lys Arg Cys Pro Glu Phe Phe Tyr Pro Glu
                  55                  60                  65

 ctg gtg aag aat atc cga ggg aag gta aaa ggc ctt cag cct gga gat      417
 Leu Val Lys Asn Ile Arg Gly Lys Val Lys Gly Leu Gln Pro Gly Asp
              70                  75                  80

 aag aag aaa gat ctg tca gat cct ttc aat gac gaa gaa aag gaa agg      465
 Lys Lys Lys Asp Leu Ser Asp Pro Phe Asn Asp Glu Glu Lys Glu Arg
          85                  90                  95

 cat aaa gta gag gcc ctt gcc cga aaa ttt gaa gaa aaa tac ggt gga      513
 His Lys Val Glu Ala Leu Ala Arg Lys Phe Glu Glu Lys Tyr Gly Gly
     100                 105                 110

 aag aaa cgt aga aaa gac cga ata cag gac ttg atc gat atg ggg tat      561
 Lys Lys Arg Arg Lys Asp Arg Ile Gln Asp Leu Ile Asp Met Gly Tyr
 115                 120                 125                 130

 ggt tat gat gaa tcc gac tcc ttc atc gat aac tct gag gcg tat gat      609
 Gly Tyr Asp Glu Ser Asp Ser Phe Ile Asp Asn Ser Glu Ala Tyr Asp
                 135                 140                 145

 gag ctt gtt cct gct tct ttg act acg aag tat gga gga ttt tac att      657
 Glu Leu Val Pro Ala Ser Leu Thr Thr Lys Tyr Gly Gly Phe Tyr Ile
             150                 155                 160

 aac tcg gga acc ctg cag ttt aga caa gca tca gag tct gaa gat gac      705
 Asn Ser Gly Thr Leu Gln Phe Arg Gln Ala Ser Glu Ser Glu Asp Asp
         165                 170                 175

 ttc att aaa gaa aag aag aaa aaa tct cca aag aag cgg aag ttg aag      753
 Phe Ile Lys Glu Lys Lys Lys Lys Ser Pro Lys Lys Arg Lys Leu Lys
     180                 185                 190

 gaa ggt ggt gag aag ata aaa aaa aaa aaa aaa gat gac act tat gac      801
 Glu Gly Gly Glu Lys Ile Lys Lys Lys Lys Lys Asp Asp Thr Tyr Asp
 195                 200                 205                 210

 aag gag aag aaa tcg aaa aag tcc aag ttt tcc aaa gcc ggc ttc aca      849
 Lys Glu Lys Lys Ser Lys Lys Ser Lys Phe Ser Lys Ala Gly Phe Thr
                 215                 220                 225

 gcc ctc aat gcc agt aag gag aag aag aag aag aaa tat tct ggg gct      897
 Ala Leu Asn Ala Ser Lys Glu Lys Lys Lys Lys Lys Tyr Ser Gly Ala
             230                 235                 240

 tta agc gtt aaa gag atg cta aag aaa ttt cag aaa gag aaa gag gct      945
 Leu Ser Val Lys Glu Met Leu Lys Lys Phe Gln Lys Glu Lys Glu Ala
         245                 250                 255

 cag aaa aaa agg gag gag gag cat aag cct gtt gcg gtc cca tca gcg      993
 Gln Lys Lys Arg Glu Glu Glu His Lys Pro Val Ala Val Pro Ser Ala
     260                 265                 270

 gaa gct cag ggc ctg cgg gaa ctg gag ggt gcc tct gac ccc ttg ctc     1041
 Glu Ala Gln Gly Leu Arg Glu Leu Glu Gly Ala Ser Asp Pro Leu Leu
 275                 280                 285                 290

 tca ctc ttt ggc tct act tct gac aac gac ttg ctc cag gcg gcc act     1089
 Ser Leu Phe Gly Ser Thr Ser Asp Asn Asp Leu Leu Gln Ala Ala Thr
                 295                 300                 305

 gcc atg gac tcg ctg acg gat ttg gac ttg gag cat ctg ctc agt gag     1137
 Ala Met Asp Ser Leu Thr Asp Leu Asp Leu Glu His Leu Leu Ser Glu
             310                 315                 320

 tct cca gaa gga agt ccc ttc cga gat atg gat gat gga agt gat tcc     1185
 Ser Pro Glu Gly Ser Pro Phe Arg Asp Met Asp Asp Gly Ser Asp Ser
         325                 330                 335

 ctt ggg gtg gga ttg gac cag gaa ttc agg cag ccc tct tct ctc ccc     1233
 Leu Gly Val Gly Leu Asp Gln Glu Phe Arg Gln Pro Ser Ser Leu Pro
     340                 345                 350

 gaa ggc ctg cca gca ccc ctg gag aag cgc gtt aag gag ctg gct cag     1281
 Glu Gly Leu Pro Ala Pro Leu Glu Lys Arg Val Lys Glu Leu Ala Gln
 355                 360                 365                 370

 gct gcc aga gct gct gag ggg gag agc aga cag aag ttc ttc acc cag     1329
 Ala Ala Arg Ala Ala Glu Gly Glu Ser Arg Gln Lys Phe Phe Thr Gln
                 375                 380                 385

 gat att aat gga atc cta tta gac ata gag gcg cag act cgg gag ctg     1377
 Asp Ile Asn Gly Ile Leu Leu Asp Ile Glu Ala Gln Thr Arg Glu Leu
             390                 395                 400

 agc agt cag gtc cgc tct ggg gtg tat gcc tat ctt gcg tca ttc ctg     1425
 Ser Ser Gln Val Arg Ser Gly Val Tyr Ala Tyr Leu Ala Ser Phe Leu
         405                 410                 415

 ccc tgc agc aag gat gcc ctg ctc aag cgt gct cgg aaa ctt cac ctc     1473
 Pro Cys Ser Lys Asp Ala Leu Leu Lys Arg Ala Arg Lys Leu His Leu
     420                 425                 430

 tat gaa cag ggg ggc cgt ctg aag gag cct ctc cag aag ctc aag gaa     1521
 Tyr Glu Gln Gly Gly Arg Leu Lys Glu Pro Leu Gln Lys Leu Lys Glu
 435                 440                 445                 450

 gcc att ggc agg gcg atg cca gag cag atg gcc aag tac cag gac gaa     1569
 Ala Ile Gly Arg Ala Met Pro Glu Gln Met Ala Lys Tyr Gln Asp Glu
                 455                 460                 465

 tgc cag gca cac acg cag gca aag gtt gcc aag atg ctg gaa gag gag     1617
 Cys Gln Ala His Thr Gln Ala Lys Val Ala Lys Met Leu Glu Glu Glu
             470                 475                 480

 aaa gac aag gag cag agg gac cgg att tgt tcg gat gag gaa gaa gat     1665
 Lys Asp Lys Glu Gln Arg Asp Arg Ile Cys Ser Asp Glu Glu Glu Asp
         485                 490                 495

 gaa gaa aaa ggg ggc agg agg ata atg gga cct cgg aag aag ttc caa     1713
 Glu Glu Lys Gly Gly Arg Arg Ile Met Gly Pro Arg Lys Lys Phe Gln
     500                 505                 510

 tgg aat gat gag atc agg gag cta ctg tgc cag gtg gtg aag atc aaa     1761
 Trp Asn Asp Glu Ile Arg Glu Leu Leu Cys Gln Val Val Lys Ile Lys
 515                 520                 525                 530

 ctg gag agc cag gac ctg gag agg aac aac aaa gcc cag gct tgg gag     1809
 Leu Glu Ser Gln Asp Leu Glu Arg Asn Asn Lys Ala Gln Ala Trp Glu
                 535                 540                 545

 gac tgt gtg aag ggc ttt ctg gat gcg gaa gtc aag ccc ctc tgg ccc     1857
 Asp Cys Val Lys Gly Phe Leu Asp Ala Glu Val Lys Pro Leu Trp Pro
             550                 555                 560

 aaa ggc tgg atg cag gcc aga act ctg ttt aag gag agc aga cga ggc     1905
 Lys Gly Trp Met Gln Ala Arg Thr Leu Phe Lys Glu Ser Arg Arg Gly
         565                 570                 575

 cat ggg cac ctg act tca atc ctg gcc aag aag aaa gtt atg gcc cct     1953
 His Gly His Leu Thr Ser Ile Leu Ala Lys Lys Lys Val Met Ala Pro
     580                 585                 590

 tct aaa atc aag gtg aag gaa tcg tct acg aag cct gat aaa aag gtt     2001
 Ser Lys Ile Lys Val Lys Glu Ser Ser Thr Lys Pro Asp Lys Lys Val
 595                 600                 605                 610

 tct gtc cca tca gga cag att ggt ggc ccc att gct ttg ccc tca gat     2049
 Ser Val Pro Ser Gly Gln Ile Gly Gly Pro Ile Ala Leu Pro Ser Asp
                 615                 620                 625

 cac caa aca gga ggc ctg agt att ggg gcc tcg agc agg gag ctc cca     2097
 His Gln Thr Gly Gly Leu Ser Ile Gly Ala Ser Ser Arg Glu Leu Pro
             630                 635                 640

 tcc cag gca tcg ggc ggc ctt gct aac cct cct cct gtc aac ctg gag     2145
 Ser Gln Ala Ser Gly Gly Leu Ala Asn Pro Pro Pro Val Asn Leu Glu
         645                 650                 655

 gac tca ttg gat gaa gac ttg atc cgc aat cca gcc tcc tcg gtg gaa     2193
 Asp Ser Leu Asp Glu Asp Leu Ile Arg Asn Pro Ala Ser Ser Val Glu
     660                 665                 670

 gcc gtg tcc aag gaa ttg gct gca ttg aat agc aga gca gct ggg aac     2241
 Ala Val Ser Lys Glu Leu Ala Ala Leu Asn Ser Arg Ala Ala Gly Asn
 675                 680                 685                 690

 tct gaa ttc aca ctg cct gca ccc tca aaa gca cct gca gaa aaa gtt     2289
 Ser Glu Phe Thr Leu Pro Ala Pro Ser Lys Ala Pro Ala Glu Lys Val
                 695                 700                 705

 gga ggc gtt tta tgt aca gaa gaa aaa agg aac ttt gcg aag cct agt     2337
 Gly Gly Val Leu Cys Thr Glu Glu Lys Arg Asn Phe Ala Lys Pro Ser
             710                 715                 720

 cct tct gct cca cca cca gct agc tct ctg cag tca ccc ctc aat ttt     2385
 Pro Ser Ala Pro Pro Pro Ala Ser Ser Leu Gln Ser Pro Leu Asn Phe
         725                 730                 735

 ctg gca gaa cag gct ctg gca ctg ggg cag tcc tct cag gag aaa aaa     2433
 Leu Ala Glu Gln Ala Leu Ala Leu Gly Gln Ser Ser Gln Glu Lys Lys
     740                 745                 750

 cca gag agt tct ggc tac aaa gag ctg tcc tgc cag gct ccc ctc aat     2481
 Pro Glu Ser Ser Gly Tyr Lys Glu Leu Ser Cys Gln Ala Pro Leu Asn
 755                 760                 765                 770

 aag ggc ctg cca gaa gta cat cag tcc aaa gct aag cac cac agc ttg     2529
 Lys Gly Leu Pro Glu Val His Gln Ser Lys Ala Lys His His Ser Leu
                 775                 780                 785

 cca cgg acg tct cac ggg ccc caa gtg gca gtt cct gtg cct ggc ccc     2577
 Pro Arg Thr Ser His Gly Pro Gln Val Ala Val Pro Val Pro Gly Pro
             790                 795                 800

 cag gtc aaa gtc ttt cat gcc ggc act cag cag cag aaa aac ttc acg     2625
 Gln Val Lys Val Phe His Ala Gly Thr Gln Gln Gln Lys Asn Phe Thr
         805                 810                 815

 ccc cca tct cca ttt gcc aat aag ctc caa ggc cca aag gct tct ccc     2673
 Pro Pro Ser Pro Phe Ala Asn Lys Leu Gln Gly Pro Lys Ala Ser Pro
     820                 825                 830

 aca cag tgt cat cgt tcc ctc ctg cag tta gtg aag aca gcg gcc aaa     2721
 Thr Gln Cys His Arg Ser Leu Leu Gln Leu Val Lys Thr Ala Ala Lys
 835                 840                 845                 850

 ggc cag ggc ttc cat ccc tct gca cca gcc acc tca gga ggc ctg tca     2769
 Gly Gln Gly Phe His Pro Ser Ala Pro Ala Thr Ser Gly Gly Leu Ser
                 855                 860                 865

 gcc tcc agc agc agc tct cac aag acc cca gcc tcg tcc tct tct gcc     2817
 Ala Ser Ser Ser Ser Ser His Lys Thr Pro Ala Ser Ser Ser Ser Ala
             870                 875                 880

 ctg agc cat cca gca aag cca cat tca gtc agc tct gca ggc tca tct     2865
 Leu Ser His Pro Ala Lys Pro His Ser Val Ser Ser Ala Gly Ser Ser
         885                 890                 895

 tac aag aat aat ccc ttt gcc agc tca atc tcc aaa cat ggg gtt tct     2913
 Tyr Lys Asn Asn Pro Phe Ala Ser Ser Ile Ser Lys His Gly Val Ser
     900                 905                 910

 tct ggc agc tct tcc tcg gga gga aca cca gtc cag agt tct gtt tct     2961
 Ser Gly Ser Ser Ser Ser Gly Gly Thr Pro Val Gln Ser Ser Val Ser
 915                 920                 925                 930

 ggg agc ctg gtc cct ggc ata cag cct ccc tcc gtg gga cag gcc acc     3009
 Gly Ser Leu Val Pro Gly Ile Gln Pro Pro Ser Val Gly Gln Ala Thr
                 935                 940                 945

 agc cga ccc gtc cca agt tca gca ggg aaa aaa atg cct gtt tcc cag     3057
 Ser Arg Pro Val Pro Ser Ser Ala Gly Lys Lys Met Pro Val Ser Gln
             950                 955                 960

 aag ttg act ctg gta gcc cct cca ggc ggt cca aac gga gat tcc agt     3105
 Lys Leu Thr Leu Val Ala Pro Pro Gly Gly Pro Asn Gly Asp Ser Ser
         965                 970                 975

 ggt ggg acc cag gga gtg gca aag ttg ctg acc tcg ccg tcc cta aag     3153
 Gly Gly Thr Gln Gly Val Ala Lys Leu Leu Thr Ser Pro Ser Leu Lys
     980                 985                 990

 ccc tct gca gtt agt agt gtg aca tcg tct acc tcc ttg tca aaa gga     3201
 Pro Ser Ala Val Ser Ser Val Thr Ser Ser Thr Ser Leu Ser Lys Gly
 995                1000                1005                1010

 gcg agt ggg act gtg ctg ctg gcc ggc tcc tct ttg atg gct tca ccc     3249
 Ala Ser Gly Thr Val Leu Leu Ala Gly Ser Ser Leu Met Ala Ser Pro
                1015                1020                1025

 tac aaa tcc agc agc cca aag ctg tct ggg gcc atg agc tcg aac tcc     3297
 Tyr Lys Ser Ser Ser Pro Lys Leu Ser Gly Ala Met Ser Ser Asn Ser
            1030                1035                1040

 ttg gga att ata acc cct gtc cct att cct gtc cat gtg ctc tcc ttc     3345
 Leu Gly Ile Ile Thr Pro Val Pro Ile Pro Val His Val Leu Ser Phe
        1045                1050                1055

 agc gct gac tcc tct gcc aaa gca ggg gtc tcc aag gat gcc atc gtc     3393
 Ser Ala Asp Ser Ser Ala Lys Ala Gly Val Ser Lys Asp Ala Ile Val
    1060                1065                1070

 aca ggc cct gcc ccc ggg tcc ttc cac cat ggc ctt ggc cac agt ctt     3441
 Thr Gly Pro Ala Pro Gly Ser Phe His His Gly Leu Gly His Ser Leu
1075                1080                1085                1090

 ctg gct ggc ttg cac tcc agc ccg ccc cat gca gcg cct ctc cca cac     3489
 Leu Ala Gly Leu His Ser Ser Pro Pro His Ala Ala Pro Leu Pro His
                1095                1100                1105

 gct gcg gtg ccc acc cat atc ccg cag agt ctg cca ggt gct tct cag     3537
 Ala Ala Val Pro Thr His Ile Pro Gln Ser Leu Pro Gly Ala Ser Gln
            1110                1115                1120

 ctt cac ggg aaa ggg cct gct gta cca cgg aaa ttg tgac cgcttcagag     3587
 Leu His Gly Lys Gly Pro Ala Val Pro Arg Lys Leu 
        1125                1130

 ggcaaggctt gccacttggg tctggggttg gaattcagaa cgtgcaggtt tttccagggt   3647

 ttaacattca ctgcggcctt ttttgtcgtt tggttttttc ttggaggagg tgagtttttc   3707

 agggaggttt tttgggattt ttgatgtgct ctccagggag ggagcccggg ctctgtcgtt   3767

 aaggaggtta agatcttccg tgtctttggg ttttagtttt ttcgtaaaag gtttttgagg   3827

 gggaagtttg ggttt                                                    3842




      <210> 54
      <211> 690
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (116)..(328)

      <400> 54
 ctctgtcacc cagtctggag cgcagtggtg tgatcacagc tcactgcagc ctctacttcc     60

 tgggatcaag taattctcct gccccagcct ccaatgtagc tgggactaca ggtgc atg     118
                                                              Met
                                                                1

 aca cca tgt ctg gct aat ttg ttt ttt ttt aaa cta gag gga ggg ttt      166
 Thr Pro Cys Leu Ala Asn Leu Phe Phe Phe Lys Leu Glu Gly Gly Phe
               5                  10                  15

 tgc cat gtt gcc cag act agt ctc aaa ctc cta ggt tca agc agt cct      214
 Cys His Val Ala Gln Thr Ser Leu Lys Leu Leu Gly Ser Ser Ser Pro
          20                  25                  30

 ttc atc ttg gcc tcc aga agt act ggg att aca ggc atg aac cac cat      262
 Phe Ile Leu Ala Ser Arg Ser Thr Gly Ile Thr Gly Met Asn His His
      35                  40                  45

 gcc cag cca act tct aaa ctg atc aat atg gga gta gca ttc aat cac      310
 Ala Gln Pro Thr Ser Lys Leu Ile Asn Met Gly Val Ala Phe Asn His
  50                  55                  60                  65

 cca cag gtt aac tca ctc tagaga gaaatcttgt gagtgtaatt tgtatggtaa      364
 Pro Gln Val Asn Ser Leu 
                  70

 aactttgagc tcaaactttc cccctaccaa aaaaaaagta tctactgggg agctgcccag    424

 gtaatgcagt agctgtagga aagccttcag tgatggcttc agggagtcac atgacaactc    484

 acaataaggg gaaaccctgt gtgtggcatc aaaaatggaa aaccagggga cactcattcc    544

 ttaagtcaca tttcggagat catacaacag aggaatatgt tgagtataca cagtgttgaa    604

 aagcctgtga cacaaacagt catattacca agcacaagac agtatagttt ggtatgctat    664

 aaaagccttg aatattctct ccattt                                         690




      <210> 55
      <211> 814
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (131)..(811)

      <400> 55
 tgtcctggag gaagaacggc acagacggag ggaggctggg gttggcagag actgggacgg     60

 aagtccctca gtcccccagg agcctccttc atggacccgg ggatcccaag aggggctgcc    120

 tcaacttagg   atg ggc aac tgt gtc aag tat cca ctg aga aat ctc tca     169
              Met Gly Asn Cys Val Lys Tyr Pro Leu Arg Asn Leu Ser
                1               5                  10

 agg aag atg tgc cag gag gaa cag acc agc tac atg gtg gtg cag acg      217
 Arg Lys Met Cys Gln Glu Glu Gln Thr Ser Tyr Met Val Val Gln Thr
      15                  20                  25

 agc gag gag ggg ctg gcg gct gac gcc gag ctc ccg gga ccg ctc ctg      265
 Ser Glu Glu Gly Leu Ala Ala Asp Ala Glu Leu Pro Gly Pro Leu Leu
  30                  35                  40                  45

 atg ctg gcc cag aac tgc gca gtc atg cac aac ctg ctg ggc cct gcc      313
 Met Leu Ala Gln Asn Cys Ala Val Met His Asn Leu Leu Gly Pro Ala
                  50                  55                  60

 tgc att ttc ctg cgc aag ggc ttc gct gag aac agg cag cct gat aga      361
 Cys Ile Phe Leu Arg Lys Gly Phe Ala Glu Asn Arg Gln Pro Asp Arg
              65                  70                  75

 tca ctg cga cca gag gaa att gaa gag ctc cga gag gcc ttc aga gaa      409
 Ser Leu Arg Pro Glu Glu Ile Glu Glu Leu Arg Glu Ala Phe Arg Glu
          80                  85                  90

 ttc gac aag gac aag gat ggc tac atc aac tgc cgg gat ctg ggc aac      457
 Phe Asp Lys Asp Lys Asp Gly Tyr Ile Asn Cys Arg Asp Leu Gly Asn
      95                 100                 105

 tgg atg cgc acc atg ggc tac atg ccc acc gag atg gag ctc atc gaa      505
 Trp Met Arg Thr Met Gly Tyr Met Pro Thr Glu Met Glu Leu Ile Glu
 110                 115                 120                 125

 ctg tcc cag cag atc aac atg aac ctg ggt ggc cat gta gat ttt gat      553
 Leu Ser Gln Gln Ile Asn Met Asn Leu Gly Gly His Val Asp Phe Asp
                 130                 135                 140

 gac ttc gtg gag cta atg ggg cct aaa ctc ctg gca gag aca gca gat      601
 Asp Phe Val Glu Leu Met Gly Pro Lys Leu Leu Ala Glu Thr Ala Asp
             145                 150                 155

 atg att ggt gta aag gaa ctg cga gat gct ttc cga gag ttt gac acc      649
 Met Ile Gly Val Lys Glu Leu Arg Asp Ala Phe Arg Glu Phe Asp Thr
         160                 165                 170

 aat ggt gat ggg gaa ata agc acc agt gag ctg cga gag gct atg agg      697
 Asn Gly Asp Gly Glu Ile Ser Thr Ser Glu Leu Arg Glu Ala Met Arg
     175                 180                 185

 aag ctc ctg ggt cat cag gtg gga cac cga gac ata gag gaa att atc      745
 Lys Leu Leu Gly His Gln Val Gly His Arg Asp Ile Glu Glu Ile Ile
 190                 195                 200                 205

 cga gat gtg gac ctc aat ggg gat gga cga gtg gac ttt gaa gag ttt      793
 Arg Asp Val Asp Leu Asn Gly Asp Gly Arg Val Asp Phe Glu Glu Phe
                 210                 215                 220

 gtc cgg atg atg tcc cgc tga                                          814
 Val Arg Met Met Ser Arg 
             225





      <210> 56
      <211> 1812
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (162)..(953)

      <400> 56
 tcccagcatg gctgtctctg cagtcgaggg caaggactct gcgtgcattc tccactgccg     60

 tctactcggc cactccggtc ccgacaccta gcctgccgga aagaacaccc ggaaatgaaa    120

 ggccaccaag aagaaaggca ctacctccta ggacagagaa a    atg gct gtt gac     173
                                                  Met Ala Val Asp
                                                    1

 cag gac tgg cct agt gtt tac cca gtt gca gca cca ttt aaa ccc tct      221
 Gln Asp Trp Pro Ser Val Tyr Pro Val Ala Ala Pro Phe Lys Pro Ser
   5                  10                  15                  20

 gca gta cct ctt cct gtt cga atg ggt tat cca gta aaa aag ggc gtg      269
 Ala Val Pro Leu Pro Val Arg Met Gly Tyr Pro Val Lys Lys Gly Val
                  25                  30                  35

 ccc atg gca aag gag gga aat cta gaa ctt tta aag att ccc aat ttt      317
 Pro Met Ala Lys Glu Gly Asn Leu Glu Leu Leu Lys Ile Pro Asn Phe
              40                  45                  50

 ctg cat ttg act cct gta gca att aaa aag cac tgt gaa gcc ctt aaa      365
 Leu His Leu Thr Pro Val Ala Ile Lys Lys His Cys Glu Ala Leu Lys
          55                  60                  65

 gat ttt tgc act gag tgg cca gcc gca ctg gac agt gac gag aaa tgt      413
 Asp Phe Cys Thr Glu Trp Pro Ala Ala Leu Asp Ser Asp Glu Lys Cys
      70                  75                  80

 gag aag cat ttt cca att gaa att gac agc act gat tat gtt tca tca      461
 Glu Lys His Phe Pro Ile Glu Ile Asp Ser Thr Asp Tyr Val Ser Ser
  85                  90                  95                 100

 gga cca tct gtt cgg aac ccc aga gca cga gta gta gtc tta aga gta      509
 Gly Pro Ser Val Arg Asn Pro Arg Ala Arg Val Val Val Leu Arg Val
                 105                 110                 115

 aag ctt tcc agt ttg aat tta gat gat cac gca aag aag aaa tta att      557
 Lys Leu Ser Ser Leu Asn Leu Asp Asp His Ala Lys Lys Lys Leu Ile
             120                 125                 130

 aaa ctt gta gga gag cga tac tgc aag acc aca gat gtg ctt acc atc      605
 Lys Leu Val Gly Glu Arg Tyr Cys Lys Thr Thr Asp Val Leu Thr Ile
         135                 140                 145

 aaa aca gat agg tgc cct tta agg agg cag aat tac gat tat gca gtg      653
 Lys Thr Asp Arg Cys Pro Leu Arg Arg Gln Asn Tyr Asp Tyr Ala Val
     150                 155                 160

 tat cta cta aca gtg tta tac cat gag tct tgg aat act gaa gaa tgg      701
 Tyr Leu Leu Thr Val Leu Tyr His Glu Ser Trp Asn Thr Glu Glu Trp
 165                 170                 175                 180

 gaa aaa agt aag act gaa gca gac atg gaa gag tat ata tgg gaa aat      749
 Glu Lys Ser Lys Thr Glu Ala Asp Met Glu Glu Tyr Ile Trp Glu Asn
                 185                 190                 195

 agc tca tca gaa aga aat atc ctg gaa acg ctt ctc cag atg aaa gct      797
 Ser Ser Ser Glu Arg Asn Ile Leu Glu Thr Leu Leu Gln Met Lys Ala
             200                 205                 210

 gct gag aaa aat atg gaa ata aat aaa gaa gag ctc ctt ggt act aaa      845
 Ala Glu Lys Asn Met Glu Ile Asn Lys Glu Glu Leu Leu Gly Thr Lys
         215                 220                 225

 gaa att gaa gag tac aaa aag tct gtt gtt agt ctt aaa aat gag gag      893
 Glu Ile Glu Glu Tyr Lys Lys Ser Val Val Ser Leu Lys Asn Glu Glu
     230                 235                 240

 gaa aat gaa aat tcc att tct cag tac aaa gaa tcc gtg aag aga cta      941
 Glu Asn Glu Asn Ser Ile Ser Gln Tyr Lys Glu Ser Val Lys Arg Leu
 245                 250                 255                 260

 tta aat gtg aca tga attatggagt agaaaaatct gcttgattta ttaattttat      996
 Leu Asn Val Thr 


 gatatatgtg atcagtatct aatttgatat aaaattgaaa atgttaaaaa atcatttttt   1056

 ttcctcagag ttaaaattat ttccctcata ctaatgctta atggcaatga ttactccaga   1116

 gttttttaat ttttacactg gggcaataga ctaggaggtc tctgatttct tcttggtcta   1176

 aagtgttttg attttatttc tacataatag ctttggtatt catgtatata catgcattta   1236

 attgtgattt tatcaccttt cccatttctt tccccacaag ctggcatttc agtagttgct   1296

 tttgaataat ggttttggtt acctgggaag gcaggcccag aacccatttc cttgacttgc   1356

 agttccgggc tgtgttcaca tgactgctgt ctagctgatg catttttcac atttgtcaac   1416

 tctggttaga aacaggtcct caggagtatt ctctaacctg atattttcta aaaagatatg   1476

 ttgattcaac tttgtttagc atcctacttt ctagattgtg gggctcattt tgccagggcc   1536

 aagctaccag aaaagtagaa gtggagatta cctggtatgt atctctctgg gtgccccagt   1596

 tagagctgcc acagctcagg aaaaagatga ggcataacga ccttgaatgt aattggagta   1656

 agtgacaaaa taagaactac cctgggaaac cctgcattca atgtagctgt caattcagta   1716

 tttttaagta cacctgtcag ctgtttctta ccacttcgat ggttgtgatt aatttaaaat   1776

 caaaataaag gaattactga gtttaaaaaa aaaaaa                             1812




      <210> 57
      <211> 1288
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (37)..(747)

      <400> 57
 gcccggaatt cccgggtcga cgatttcgtc gggaag  atg gcg gcc tcc agg aat      54
                                          Met Ala Ala Ser Arg Asn
                                            1               5

 ggg ttt gaa gcc gtg gag gca gag ggc agc gca ggg tgc cgg gga agc      102
 Gly Phe Glu Ala Val Glu Ala Glu Gly Ser Ala Gly Cys Arg Gly Ser
              10                  15                  20

 tcg gga atg gag gtg gtg ctt cct ttg gat cct gcc gtc ccc gcc ccg      150
 Ser Gly Met Glu Val Val Leu Pro Leu Asp Pro Ala Val Pro Ala Pro
          25                  30                  35

 ctg tgc cct cac gga ccc act ctt ctg ttt gta aag gtg acc caa ggg      198
 Leu Cys Pro His Gly Pro Thr Leu Leu Phe Val Lys Val Thr Gln Gly
      40                  45                  50

 aaa gaa gaa act cgg agg ttt tat gcc tgt tca gcc tgt aga gat aga      246
 Lys Glu Glu Thr Arg Arg Phe Tyr Ala Cys Ser Ala Cys Arg Asp Arg
  55                  60                  65                  70

 aaa gac tgt aat ttt ttt cag tgg gaa gat gaa aag ttg tca gga gct      294
 Lys Asp Cys Asn Phe Phe Gln Trp Glu Asp Glu Lys Leu Ser Gly Ala
                  75                  80                  85

 aga ctt gct gcc cga gaa gct cat aac cga aga tgt cag cct ccc ctg      342
 Arg Leu Ala Ala Arg Glu Ala His Asn Arg Arg Cys Gln Pro Pro Leu
              90                  95                 100

 tcc cga acg cag tgt gtg gaa agg tac ttg aag ttt att gag ttg ccc      390
 Ser Arg Thr Gln Cys Val Glu Arg Tyr Leu Lys Phe Ile Glu Leu Pro
         105                 110                 115

 ttg act cag aga aag ttt tgt caa aca tgt cag cag ttg ttg tta cca      438
 Leu Thr Gln Arg Lys Phe Cys Gln Thr Cys Gln Gln Leu Leu Leu Pro
     120                 125                 130

 gat gac tgg ggg caa cat agt gag cat cag gtt ctg ggt aat gtg tcc      486
 Asp Asp Trp Gly Gln His Ser Glu His Gln Val Leu Gly Asn Val Ser
 135                 140                 145                 150

 att acc cag tta aga agg ccc agt caa ctc ctt tat cca ctg gaa aac      534
 Ile Thr Gln Leu Arg Arg Pro Ser Gln Leu Leu Tyr Pro Leu Glu Asn
                 155                 160                 165

 aag aag aca aat gcc cag tat ctg ttt gct gat cgg agc tgt cag ttc      582
 Lys Lys Thr Asn Ala Gln Tyr Leu Phe Ala Asp Arg Ser Cys Gln Phe
             170                 175                 180

 ttg gta gac tta ctt tct gcc ctc gga ttc aga aga gta ctg tgt gtt      630
 Leu Val Asp Leu Leu Ser Ala Leu Gly Phe Arg Arg Val Leu Cys Val
         185                 190                 195

 gga aca cca agg ttg cat gag ctg atc aag ttg aca gca tca ggt gac      678
 Gly Thr Pro Arg Leu His Glu Leu Ile Lys Leu Thr Ala Ser Gly Asp
     200                 205                 210

 aag aag tct aac att aaa agc ctt tta ttg gat att gat ttt cgg tat      726
 Lys Lys Ser Asn Ile Lys Ser Leu Leu Leu Asp Ile Asp Phe Arg Tyr
 215                 220                 225                 230

 tca cag ttt tta tat gga aga ta gcttttgcca ttataatatg tttaaccatc      779
 Ser Gln Phe Leu Tyr Gly Arg 
                 235

 atttctttga tggaaagact gcccttgaag tatgcagagc atttttacag gaagataaag    839

 gcgaaggaat cattatggtg acggatcctc cgtttggtgg cttggttgaa cctctggcta    899

 ttacattcaa gaagttaatt gctatgtgga aagaaggtca aagccaagat gacagtcaca    959

 aagaactacc cattttctgg attttcccct atttttttga atcccgaatt tgtcagtttt   1019

 ttccaagctt ccagatgctg gattaccagg tagattatga taatcatgca ctttataaac   1079

 acgccgagac cggtcggcga cagtctcccg ggcgtagttt caccggcatt tcgcccaaca   1139

 aaataatcct tcctactgaa gaagggtaca gattttgctc tccgtgtcaa ggtaatgttt   1199

 ctctagagaa tcaacactgt gagcactgta attcttgcac atccaaggat ggcaggaaat   1259

 ggaaccattg ctttatctgt aaaaaaaaa                                     1288




      <210> 58
      <211> 811
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (27)..(542)

      <400> 58
 gtctccgtga ggaggcgcgc ggggcc atg acg tca gcg tcc aca aag gtc gga      53
                              Met Thr Ser Ala Ser Thr Lys Val Gly
                                1               5

 gag atc ttc tcg gcg gcc ggc gcc gcc ttc acg aag ctc ggg gag ctg      101
 Glu Ile Phe Ser Ala Ala Gly Ala Ala Phe Thr Lys Leu Gly Glu Leu
  10                  15                  20                  25

 acg atg cag ctg cat ccc gtg gcc gac tct tct cct gcg ggc gcg aag      149
 Thr Met Gln Leu His Pro Val Ala Asp Ser Ser Pro Ala Gly Ala Lys
                  30                  35                  40

 tgg acg gag acg gaa ata gag atg ctg agg gct gct gtg aag cga ttt      197
 Trp Thr Glu Thr Glu Ile Glu Met Leu Arg Ala Ala Val Lys Arg Phe
              45                  50                  55

 ggg gac gat ctt aat cac atc agc tgt gtc atc aag gaa cgg aca gtg      245
 Gly Asp Asp Leu Asn His Ile Ser Cys Val Ile Lys Glu Arg Thr Val
          60                  65                  70

 gcc cag ata aag gcc act gtg aaa cgc aag gta tat gaa gat tct ggc      293
 Ala Gln Ile Lys Ala Thr Val Lys Arg Lys Val Tyr Glu Asp Ser Gly
      75                  80                  85

 atc ccc ctt cca gct gag tca ccc aag aaa ggg ccc aag aag gtg gca      341
 Ile Pro Leu Pro Ala Glu Ser Pro Lys Lys Gly Pro Lys Lys Val Ala
  90                  95                 100                 105

 tct ggt gtc ttg tca cct cct cca gct gcc cct cct ccc agc agc tcc      389
 Ser Gly Val Leu Ser Pro Pro Pro Ala Ala Pro Pro Pro Ser Ser Ser
                 110                 115                 120

 agt gtc cct gag gcc ggg ggt ccc ccc ata aag aaa cag aag gct gat      437
 Ser Val Pro Glu Ala Gly Gly Pro Pro Ile Lys Lys Gln Lys Ala Asp
             125                 130                 135

 gtg aca ctc agt gct ctg aac gac tcc gat gcc aac agt gac gtg gtg      485
 Val Thr Leu Ser Ala Leu Asn Asp Ser Asp Ala Asn Ser Asp Val Val
         140                 145                 150

 gat att gaa ggg cta gga gaa act cct cca gct aag aaa ctc aac ttc      533
 Asp Ile Glu Gly Leu Gly Glu Thr Pro Pro Ala Lys Lys Leu Asn Phe
     155                 160                 165

 gac cag gcc tgaccct ggattctggc cttctcatga cctctgctga tcctcctctc      589
 Asp Gln Ala 
 170

 ctctcctgct gagccttcca cctctgacct ctcactgttc atgccggacc tgtggatctc    649

 ctgggactcc gagcaaggcc tgcacgagag agggctgaaa ggctgctggg gctgccacct    709

 cgctattccc gcataagcat ctgcccccaa cccctttgac cttcatctga tggacatttt    769

 tatacagaaa acaataaaga tttccctctc aaaaaaaaaa aa                       811




      <210> 59
      <211> 1252
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (706)..(939)

      <400> 59
 gcacgaggga tggcttgggg catgggaggg gccagggagg gaacctagtg caggtgtgag     60

 ctgccagtgt tgcagaccca tcacaaacct ccccctcaaa gaaagcacat ccgcctggca    120

 gagctcctaa gcctcgagca gctgccagga gactcatttc aattaggaca catgtctgga    180

 ggccacccca aggtggctgg gggcagagtg aggcaggagg ccctgcaatt ccagggttgc    240

 ccaggcactg agaatcctgg ctctcatcat aatgggctga ggttctgggg acaatctgag    300

 tggcggctct gagcaagctg agcccaggga ggctttgagg tacacagggt cccttggggg    360

 gcctgagagc agccatgagg aggcacagtg agacagatgt ggaagagcag acccaggagc    420

 tgaagaccat cactcagctc cagggtgagc ctgcaccgcc gtgaccagtc tccctttccc    480

 gtctgggggt ttctgggtgc acaacttttt gtggggaaaa gagagatcag attgttactg    540

 tctatgtaga aaaggaagac ataagaaact ccattttgat ctgtactaag aaaaattgtt    600

 tctgctttga gatgctatta acctgtaact ttagccccaa ctctgtgctc acagaaacat    660

 gtgctgtatt gaatcaaaga ttaatgcatt taggggccgt gcagg    atg tgc ttt     714
                                                      Met Cys Phe
                                                        1

 gtt aac aat gtg ttt gca ggc agt atg ctt ggt aaa agt cat ccc cat      762
 Val Asn Asn Val Phe Ala Gly Ser Met Leu Gly Lys Ser His Pro His
       5                  10                  15

 cct cca ttc ttg att aac cag gga cac agt gca ctg cag aaa gcc gca      810
 Pro Pro Phe Leu Ile Asn Gln Gly His Ser Ala Leu Gln Lys Ala Ala
  20                  25                  30                  35

 ggg acc tct gcc cag gaa agc ctg gga att gtc caa ggt ttc ccc cca      858
 Gly Thr Ser Ala Gln Glu Ser Leu Gly Ile Val Gln Gly Phe Pro Pro
                  40                  45                  50

 ctg aga cag cct gag ata tgg cct cgt ggg aaa gga aag atc tta cca      906
 Leu Arg Gln Pro Glu Ile Trp Pro Arg Gly Lys Gly Lys Ile Leu Pro
              55                  60                  65

 tcc ccc agc ccg aca cca gta aag ggt ctg tgc tgaggagt agtgaaagag      957
 Ser Pro Ser Pro Thr Pro Val Lys Gly Leu Cys 
          70                  75

 ggaggcctct ttgcagttga gataagagga aggcatctgt ctcctgctcg tccctgggaa   1017

 tggaatgtct cagtgtaaag ccgaccattc ccattcgttc tattctaaga taggagaaaa   1077

 ccgctctgtg gctagaggca agatatgctg gcagcaatac tgctctgtta ctctttgcta   1137

 cactgagatg tttgtgtaac gtgaaacaaa tctggcctac gtgcacatct gggcatagta   1197

 cctttccttg aacttattca tgataaagat tcctttgctc aaaaaaaaaa aaaaa        1252




      <210> 60
      <211> 1325
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (186)..(917)

      <400> 60
 gcggttgact gtagagccgc tctctctcac tggcacagcg aggttttgct cagcccttgt     60

 ctcgggaccg caggtacgtg cctggcgact tcttcgggtg gtccccgtcc gccctcctcg    120

 tccctaccca gtttcttgct tccctgcccc atctccgccg ctccccgcag cctccgccga    180

 gcgcc    atg gct cct agg aag ggc agt agt cgg gtg gcc aag acc aac     227
          Met Ala Pro Arg Lys Gly Ser Ser Arg Val Ala Lys Thr Asn
            1               5                  10

 tcc tta cgg agg cgg aag ctc gcc tcc ttt ctg aaa gac ttc gac cgt      275
 Ser Leu Arg Arg Arg Lys Leu Ala Ser Phe Leu Lys Asp Phe Asp Arg
  15                  20                  25                  30

 gaa gtg gaa ata cga atc aag caa att gag tca gac agg cag aac ctc      323
 Glu Val Glu Ile Arg Ile Lys Gln Ile Glu Ser Asp Arg Gln Asn Leu
                  35                  40                  45

 ctc aag gag gtg gat aac ctc tac aac atc gag atc ctg cgg ctc ccc      371
 Leu Lys Glu Val Asp Asn Leu Tyr Asn Ile Glu Ile Leu Arg Leu Pro
              50                  55                  60

 aag gct ctg cgc gag atg aac tgg ctt gac tac ttc gcc ctt gga gga      419
 Lys Ala Leu Arg Glu Met Asn Trp Leu Asp Tyr Phe Ala Leu Gly Gly
          65                  70                  75

 aac aaa cag gcc ctg gaa gag gcg gca aca gct gac ctg gat atc acc      467
 Asn Lys Gln Ala Leu Glu Glu Ala Ala Thr Ala Asp Leu Asp Ile Thr
      80                  85                  90

 gaa ata aac aaa cta aca gca gaa gct att cag aca ccc ctg aaa tct      515
 Glu Ile Asn Lys Leu Thr Ala Glu Ala Ile Gln Thr Pro Leu Lys Ser
  95                 100                 105                 110

 gcc aaa aca cga aag gta ata cag gta gat gaa atg ata gtg gaa gag      563
 Ala Lys Thr Arg Lys Val Ile Gln Val Asp Glu Met Ile Val Glu Glu
                 115                 120                 125

 gaa gaa gaa gaa gaa aat gaa cgt aag aat ctt caa act gca aga gtc      611
 Glu Glu Glu Glu Glu Asn Glu Arg Lys Asn Leu Gln Thr Ala Arg Val
             130                 135                 140

 aaa agg tgt cct cca tcc aag aag aga act cag tcc ata caa gga aaa      659
 Lys Arg Cys Pro Pro Ser Lys Lys Arg Thr Gln Ser Ile Gln Gly Lys
         145                 150                 155

 gga aaa ggg aaa agg tca agc cgt gct aac act gtt acc cca gcc gtg      707
 Gly Lys Gly Lys Arg Ser Ser Arg Ala Asn Thr Val Thr Pro Ala Val
     160                 165                 170

 ggc cga ttg gag gtg tcc atg gtc aaa cca act cca ggc ctg aca ccc      755
 Gly Arg Leu Glu Val Ser Met Val Lys Pro Thr Pro Gly Leu Thr Pro
 175                 180                 185                 190

 agg ttt gac tca agg gtc ttc aag acc cct ggc ctg cgt act cca gca      803
 Arg Phe Asp Ser Arg Val Phe Lys Thr Pro Gly Leu Arg Thr Pro Ala
                 195                 200                 205

 gca gga gag cgg att tac aac atc tca ggg aat ggc agc cct ctt gct      851
 Ala Gly Glu Arg Ile Tyr Asn Ile Ser Gly Asn Gly Ser Pro Leu Ala
             210                 215                 220

 gac agc aaa gag atc ttc ctc act gtg cca gtg ggc ggc gga gag agc      899
 Asp Ser Lys Glu Ile Phe Leu Thr Val Pro Val Gly Gly Gly Glu Ser
         225                 230                 235

 cct gcg att att ggc cag tgactt gcagaggcac agtattgccc agctggatcc      953
 Pro Ala Ile Ile Gly Gln 
     240

 agaggccttg ggaaacatta agaagctctc caaccgtctc gcccaaatct gcagcagcat   1013

 acggacccac aaatgagaca ccaaagttga caggatggac ttttaatggg cacttctggg   1073

 accctgaaga gacttcttcc cttcaggctt attgtttgag tgtgaagttc cagagcaagg   1133

 agccatgttc ctctaaggga attcaggaat tcagacgtgc tattcccaca ccagttaggt   1193

 agagctgtct gttcaccctc ccatcccagc tgatcccagt cactgcttgc tggggccatg   1253

 ccatggaagc ttcccatcag tctcccagct gaatcctccc tgctctctga gctgctgcct   1313

 tttgcctcct gc                                                       1325




      <210> 61
      <211> 4266
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (7)..(1476)

      <400> 61
 aacaag   atg gag gat tcg gcc tcg gcc tcg ctg tct tct gca gcc gct      48
          Met Glu Asp Ser Ala Ser Ala Ser Leu Ser Ser Ala Ala Ala
            1               5                  10

 act gga acc tcc acc tcg act cca gcg gcc ccg aca gca cgg aag cag       96
 Thr Gly Thr Ser Thr Ser Thr Pro Ala Ala Pro Thr Ala Arg Lys Gln
  15                  20                  25                  30

 ctg gat aaa gaa cag gtt aga aag gca gtg gac gct ctc ttg acg cat      144
 Leu Asp Lys Glu Gln Val Arg Lys Ala Val Asp Ala Leu Leu Thr His
                  35                  40                  45

 tgc aag tcc agg aaa aac aat tat ggg ttg ctt ttg aat gag aat gaa      192
 Cys Lys Ser Arg Lys Asn Asn Tyr Gly Leu Leu Leu Asn Glu Asn Glu
              50                  55                  60

 agt tta ttt tta atg gtg gta tta tgg aaa att cca agt aaa gaa ctg      240
 Ser Leu Phe Leu Met Val Val Leu Trp Lys Ile Pro Ser Lys Glu Leu
          65                  70                  75

 agg gtc aga ttg acc ttg cct cat agt att cga tca gat tca gaa gat      288
 Arg Val Arg Leu Thr Leu Pro His Ser Ile Arg Ser Asp Ser Glu Asp
      80                  85                  90

 atc tgt tta ttt acg aag gat gaa ccc aat tca act cct gaa aag aca      336
 Ile Cys Leu Phe Thr Lys Asp Glu Pro Asn Ser Thr Pro Glu Lys Thr
  95                 100                 105                 110

 gaa cag ttt tat aga aag ctt tta aac aag cat gga att aaa acc gtt      384
 Glu Gln Phe Tyr Arg Lys Leu Leu Asn Lys His Gly Ile Lys Thr Val
                 115                 120                 125

 tct cag att atc tcc ctc caa act cta aag aag gaa tat aaa tcc tat      432
 Ser Gln Ile Ile Ser Leu Gln Thr Leu Lys Lys Glu Tyr Lys Ser Tyr
             130                 135                 140

 gaa gcc aag ctc cgc ctt ctg agc agt ttt gat ttc ttc ctt act gat      480
 Glu Ala Lys Leu Arg Leu Leu Ser Ser Phe Asp Phe Phe Leu Thr Asp
         145                 150                 155

 gac aga att agg cgg ctc tta ccc tca ctc att ggg aga cat ttc tat      528
 Asp Arg Ile Arg Arg Leu Leu Pro Ser Leu Ile Gly Arg His Phe Tyr
     160                 165                 170

 caa aga aag aaa gtt cca gta tct gta aac ctt ctg tcc aag aat tta      576
 Gln Arg Lys Lys Val Pro Val Ser Val Asn Leu Leu Ser Lys Asn Leu
 175                 180                 185                 190

 tca aga gag atc aat gac tgt ata ggt gga acg gtc tta aac att tct      624
 Ser Arg Glu Ile Asn Asp Cys Ile Gly Gly Thr Val Leu Asn Ile Ser
                 195                 200                 205

 aaa agt ggt tct tgc agt gct ata cgt att ggt cac gtt gga atg caa      672
 Lys Ser Gly Ser Cys Ser Ala Ile Arg Ile Gly His Val Gly Met Gln
             210                 215                 220

 att gag cac atc att gaa aac att gtt gct gtc acc aaa gga ctt tca      720
 Ile Glu His Ile Ile Glu Asn Ile Val Ala Val Thr Lys Gly Leu Ser
         225                 230                 235

 gaa aaa ttg cca gag aag tgg gag agc gtg aaa ctc ctg ttt gtg aaa      768
 Glu Lys Leu Pro Glu Lys Trp Glu Ser Val Lys Leu Leu Phe Val Lys
     240                 245                 250

 act gag aaa tcg gct gca ctt ccc atc ttt tcc tcg ttt gtc agc aat      816
 Thr Glu Lys Ser Ala Ala Leu Pro Ile Phe Ser Ser Phe Val Ser Asn
 255                 260                 265                 270

 tgg gat gaa gcc acc aaa aga tct ttg ctt aat aag aag aaa aaa gag      864
 Trp Asp Glu Ala Thr Lys Arg Ser Leu Leu Asn Lys Lys Lys Lys Glu
                 275                 280                 285

 gca agg aga aaa cga aga gaa aga aat ttt gaa aaa caa aag gag agg      912
 Ala Arg Arg Lys Arg Arg Glu Arg Asn Phe Glu Lys Gln Lys Glu Arg
             290                 295                 300

 aag aag aag agg cag cag gct agg aag act gca tca gtt ctt agt aaa      960
 Lys Lys Lys Arg Gln Gln Ala Arg Lys Thr Ala Ser Val Leu Ser Lys
         305                 310                 315

 gat gat gtg gca cct gaa agt ggt gat act aca gtg aag aaa cct gaa     1008
 Asp Asp Val Ala Pro Glu Ser Gly Asp Thr Thr Val Lys Lys Pro Glu
     320                 325                 330

 tca aag aag gaa cag acc cca gag cat ggg aag aaa aaa cgt ggc aga     1056
 Ser Lys Lys Glu Gln Thr Pro Glu His Gly Lys Lys Lys Arg Gly Arg
 335                 340                 345                 350

 gga aaa gcc caa gtt aaa gca aca aat gaa tcc gaa gac gaa atc cca     1104
 Gly Lys Ala Gln Val Lys Ala Thr Asn Glu Ser Glu Asp Glu Ile Pro
                 355                 360                 365

 cag ctg gta cca ata gga aag aag act cca gct aat gaa aaa gta gag     1152
 Gln Leu Val Pro Ile Gly Lys Lys Thr Pro Ala Asn Glu Lys Val Glu
             370                 375                 380

 att caa aaa cat gcc aca gga aag aag tct cca gca aag agt cct aat     1200
 Ile Gln Lys His Ala Thr Gly Lys Lys Ser Pro Ala Lys Ser Pro Asn
         385                 390                 395

 ccc agc aca cct cgt ggg aag aaa aga aag gct ttg cca gca tct gag     1248
 Pro Ser Thr Pro Arg Gly Lys Lys Arg Lys Ala Leu Pro Ala Ser Glu
     400                 405                 410

 acc cca aaa gct gca gag tct gag acc cca ggg aaa agc cca gag aag     1296
 Thr Pro Lys Ala Ala Glu Ser Glu Thr Pro Gly Lys Ser Pro Glu Lys
 415                 420                 425                 430

 aag cca aaa atc aaa gaa gag gca gtg aag gaa aaa agt cct tcg ctg     1344
 Lys Pro Lys Ile Lys Glu Glu Ala Val Lys Glu Lys Ser Pro Ser Leu
                 435                 440                 445

 ggg aaa aaa gat gcg aga cag act cca aaa aag cca gag gcc aag ttt     1392
 Gly Lys Lys Asp Ala Arg Gln Thr Pro Lys Lys Pro Glu Ala Lys Phe
             450                 455                 460

 ttc acc act cct agt aaa tct gtg aga aaa gct tcc cac acc ccc aaa     1440
 Phe Thr Thr Pro Ser Lys Ser Val Arg Lys Ala Ser His Thr Pro Lys
         465                 470                 475

 aaa tgg ccc aaa aaa ccc aaa gta ccc cag tcg acc taaa gtcagtgatt     1490
 Lys Trp Pro Lys Lys Pro Lys Val Pro Gln Ser Thr 
     480                 485                 490

 caactggaag gaaacctcaa tgctgcctcc agagcttttt ggaaatactc agatcctggc   1550

 cgcctttgta accttctcta aacgtcaggc ctggacttaa aagatttttt aaaacctcca   1610

 taagtagtcc aggggcggtg gctcacgcct gtaatcccag cactttggga ggccgaggca   1670

 ggcggatcac aaggtcaacg agatcgagac catcctggcc aacatggtga aaccctgtct   1730

 gtaccaaaaa tacaaaaatt aattgggcat ggtggtggac acctgtaatc ccagctacta   1790

 gggaggctga ggcaggagaa ttgcttgaac ctgggaggcg gaggttgcag tgaggcgaga   1850

 tcgtgccact gcactccagc ctgggggagc caagcagacg gaaagtgagg gtagggtctc   1910

 tcagctcctg tagcagctga tccgagccta gagcccacac ctgcactcca tgcttccaga   1970

 aggcctgaag ctgacctcca accatagcca cggcctccac cgcttcggtc atggggatct   2030

 caggtgtgcg aagtccccgg actggggacc cctccggggt caccagcttc acagagccat   2090

 ccatcaacac catcaccata tcttcctcta cctgggtcac ctgcacgggt cccctgtgct   2150

 cggtgctcat ctcgcccagc cagcaagaga gcgcgccaaa gcgcaccgtg tggaagagca   2210

 ccgacttccc cggccgcccg gggctcacgc cgatgcacac agcgggcagc tcagagcctg   2270

 gcccggtcag cagcgcgaac acggacagag gcgtcggcag tgggaacagc acctgccgga   2330

 caagcaggaa tttgttcatg ggctggtacc actgaagcag gacaacggac gtctccaatg   2390

 caccgcacag gaacgggccc ccagagctcg caccctccgc cacacagcac gcccggcagc   2450

 ctttggtgtc ctggatcttg gtggaaacca tgttcttcct tgccagtagg cggtgggggc   2510

 taatgtgagc gatggggttt cctgctctgg tctctttccg ttccagcagg ccaaggatgc   2570

 tatgagaata caggtggggg gtctttcctg agagagacat gagaacgttg ttgatggagt   2630

 acacccacgt agtccggcta ggaaagagca tttccagcgt ggcctcctgg tcattccggt   2690

 tcaggatgaa gatgccttcc tctgccccca ggagcaggtg ctggtccttg gtggagggat   2750

 gtgtccaggc ggccgtgctg tggatccgga gggggcagcc attgaacaac tttacgagaa   2810

 gggcacatcc ctttctcttc atcttttcct tcttgggggg cagaagtggg ggcttgtcaa   2870

 gctcccggga gggtgggttc cagagtgagg gttctgaatg ggcggtgagg tgggggctgc   2930

 tggtggatgg gggaggccca ggacgggggc tgtttggtgg gggcccactg gcacaccgga   2990

 ccagcacccc cgggctcagc tgcccatcat cccccatgct cccaggaccc tcgtctgatg   3050

 gagaacggaa cttgggcttg gggggaagtg gaggaggtgt gtcctctgca ggggtgggga   3110

 tgtccacgtc gtcatagtca tcgtcagacg actctgacag ttgcttcctg gggctgctgc   3170

 tcctgaggtc tcgaggaggc tgtaggcgag cggtgttggc tgggggtctg gtctccattc   3230

 ctcggagctt cctgaactcc atgtgccgcc gacagcagtc tgcatctggg atccccagag   3290

 agctggagcg gtgggtggat ctgatccgcc gagggatagc agggggtagc tcgggctcct   3350

 catcctcaat gtccccaatg gagggtcctt tcccgggatt cttcagtttg tcaagaagat   3410

 ccaggatcag gcctcgattc agcccaggct gggataccag ttgatgactg agcatcttgg   3470

 tggcgctggg tcgtttcttg ggactcttag tcagagtgac tttgatgaag ttgtggaagg   3530

 cagccgacca tttgcctttt tccttcagtc ggggaggctg gtagccactc ttggtcatga   3590

 ggaagagaac tctgagaggg tgcacatcaa agagcggtgg ctgtagctcg gccagttcga   3650

 tggccgtgat gcccagggac cagatgtcac acagctcatt gtatcctccc ttcagggcca   3710

 cagctgccac ttccggagcc atccagtagg gtgtcccaat gaaagagagg cgtctggcca   3770

 gtgtagcccc aatctgggcc gagatgccaa agtcagccaa tctgacctcc ccagcatcat   3830

 tgatgaggat gttagctccc ttgatgtccc tgtgtatctt cttctgtgag tgcaaatagg   3890

 ccagtccctg gagcacttcc cggcagacat agctaatctg gagctctgac agggagcctg   3950

 tcacttggta gatgtcctgg agagaaccag ccccacagaa ttccatgcag atccagagtt   4010

 tctgcaacca gagataactc ccatggtagg ccacgatgtt ggcgtgccgg caagttttca   4070

 atatgaggat ttccttctga agggtggaga catcatcatc aggctccatc ttcaccatct   4130

 tcagtgccac caggtcccct gacaccttgt ctcgagcctt aaagacttcc ccatacgtgc   4190

 cgccacccag ccgctgtagc aggtcatagt ggtcccgggg gtctctattg aaaatgtcag   4250

 ggtccacgac gtccat                                                   4266




      <210> 62
      <211> 1191
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(1019)

      <400> 62
 ggggtccgga ggacgcccca ggcctcttgg ccagggcctc cctgatc  atg ctc ccg      56
                                                      Met Leu Pro
                                                        1

 tgg cca cta ccc ctg gcc tcc tcg gcc ctc acc ttg ctc ttc ggg gcc      104
 Trp Pro Leu Pro Leu Ala Ser Ser Ala Leu Thr Leu Leu Phe Gly Ala
       5                  10                  15

 ctc act tcc ctg ttc ctc tgg tac tgc tac cgc ctg ggc tcc caa gac      152
 Leu Thr Ser Leu Phe Leu Trp Tyr Cys Tyr Arg Leu Gly Ser Gln Asp
  20                  25                  30                  35

 atg cag gcc cta ggg gct ggg agc cga gct ggg ggt gtt cgt ggt ggg      200
 Met Gln Ala Leu Gly Ala Gly Ser Arg Ala Gly Gly Val Arg Gly Gly
                  40                  45                  50

 cct gtg gga tgc tcg gag gcc ggc ggg cca agc cca ggg ggt cct ggg      248
 Pro Val Gly Cys Ser Glu Ala Gly Gly Pro Ser Pro Gly Gly Pro Gly
              55                  60                  65

 gat ccc ggg gaa gga cct agg acg gaa ggc cta gtg agc cgg cgg ctt      296
 Asp Pro Gly Glu Gly Pro Arg Thr Glu Gly Leu Val Ser Arg Arg Leu
          70                  75                  80

 cgg gcc tac gca agg cgc tac tcc tgg gct ggg atg ggt aga gtg agg      344
 Arg Ala Tyr Ala Arg Arg Tyr Ser Trp Ala Gly Met Gly Arg Val Arg
      85                  90                  95

 cgg gca gct cag ggt ggt ggc cca ggc cct ggg aga ggg cca ggg gtc      392
 Arg Ala Ala Gln Gly Gly Gly Pro Gly Pro Gly Arg Gly Pro Gly Val
 100                 105                 110                 115

 cta ggt att cag cgc cca ggc ctg ctt ttc cta cca gac ctg cct tca      440
 Leu Gly Ile Gln Arg Pro Gly Leu Leu Phe Leu Pro Asp Leu Pro Ser
                 120                 125                 130

 gcc ccc ttt gtg ccg cgg gac gcc cag cgg cac gac gtg gag ctc ctg      488
 Ala Pro Phe Val Pro Arg Asp Ala Gln Arg His Asp Val Glu Leu Leu
             135                 140                 145

 gag agc agc ttc cct gcc att ttg cgg gac ttc ggg gct gtg agc tgg      536
 Glu Ser Ser Phe Pro Ala Ile Leu Arg Asp Phe Gly Ala Val Ser Trp
         150                 155                 160

 gac ttc tca ggg act acc cct ccg cct cgg ggc tgg tcc cca cct ctg      584
 Asp Phe Ser Gly Thr Thr Pro Pro Pro Arg Gly Trp Ser Pro Pro Leu
     165                 170                 175

 gcc ccc ggg tgc tac cag ctc ctg ctg tac caa gca ggc cgg tgc caa      632
 Ala Pro Gly Cys Tyr Gln Leu Leu Leu Tyr Gln Ala Gly Arg Cys Gln
 180                 185                 190                 195

 ccc agc aac tgc cgc cgg tgc ccg ggg gcc tat cgg gca ctg agg ggg      680
 Pro Ser Asn Cys Arg Arg Cys Pro Gly Ala Tyr Arg Ala Leu Arg Gly
                 200                 205                 210

 ctt cga agc ttt atg agt gcc aac acc ttc ggc aat gcc ggc ttt tcc      728
 Leu Arg Ser Phe Met Ser Ala Asn Thr Phe Gly Asn Ala Gly Phe Ser
             215                 220                 225

 gtt ctc ctg cct ggg gcc cgg ctc gag ggc cgc tgt ggg ccc acc aat      776
 Val Leu Leu Pro Gly Ala Arg Leu Glu Gly Arg Cys Gly Pro Thr Asn
         230                 235                 240

 gcc cgg gtc aga tgc cat ctg ggc cta aag atc cct cct ggc tgt gag      824
 Ala Arg Val Arg Cys His Leu Gly Leu Lys Ile Pro Pro Gly Cys Glu
     245                 250                 255

 ctg gtg gtc ggc ggt gag ccc cag tgc tgg gct gag ggg cac tgt cta      872
 Leu Val Val Gly Gly Glu Pro Gln Cys Trp Ala Glu Gly His Cys Leu
 260                 265                 270                 275

 ctg gtg gac gac tct ttt cta cac aca gtg gct cac aat ggc tcc ccc      920
 Leu Val Asp Asp Ser Phe Leu His Thr Val Ala His Asn Gly Ser Pro
                 280                 285                 290

 gaa gat ggg cct cga gtg gtc ttc atc gtg gac ctc tgg cac ccc aac      968
 Glu Asp Gly Pro Arg Val Val Phe Ile Val Asp Leu Trp His Pro Asn
             295                 300                 305

 gtg gca ggg gct gag cgc cag gcc ctc gac ttt gtc ttc gcc cca gac     1016
 Val Ala Gly Ala Glu Arg Gln Ala Leu Asp Phe Val Phe Ala Pro Asp
         310                 315                 320

 cct tgaa ggaaggtgct cccttcacac acccaggctg gagagacact gcgctcaggg     1073
 Pro 


 acggcttgat ggtagccagg acctcctctc tactgcgggg gtgggcgggg gcggaggatg   1133

 ggaactggct agtgagcact gaaatataaa ttctgaatcc tctcctaaaa aaaaaaaa     1191




      <210> 63
      <211> 3029
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (251)..(2854)

      <400> 63
 tacagggtaa actgggtcca ggtggcgtag ccgccgcgac accttcacgt gaccgcggac     60

 agcttaagga accccgcatc cagtgcgcct gcgctggagc tcccggaagt tgccggaccc    120

 ggaacgcagg cggagcgcaa gtctgtcagc cagtcagtcc gccagtccgc cagcccagta    180

 cctctctctc ctcggccctc gtaagctgtc cgcggtctgt ttggcccgaa cggcggcgga    240

 ggcgctgatc   atg gcg aca ttc atc tcg gtg cag ctg aaa aag acc tca     289
              Met Ala Thr Phe Ile Ser Val Gln Leu Lys Lys Thr Ser
                1               5                  10

 gag gtg gac ctg gcc aag ccg ctg gtg aag ttc atc cag cag act tac      337
 Glu Val Asp Leu Ala Lys Pro Leu Val Lys Phe Ile Gln Gln Thr Tyr
      15                  20                  25

 cca agc ggc ggg gaa gag cag gcc cag tac tgc cgc gcg gcg gag gag      385
 Pro Ser Gly Gly Glu Glu Gln Ala Gln Tyr Cys Arg Ala Ala Glu Glu
  30                  35                  40                  45

 ctc agc aag ctg cgc cgc gcc gca gtc ggt cgt ccg ctg gac aag cac      433
 Leu Ser Lys Leu Arg Arg Ala Ala Val Gly Arg Pro Leu Asp Lys His
                  50                  55                  60

 gag ggc gcg ctc gag acg ctc ctg aga tat tat gat cag att tgt tct      481
 Glu Gly Ala Leu Glu Thr Leu Leu Arg Tyr Tyr Asp Gln Ile Cys Ser
              65                  70                  75

 att gaa ccc aaa ttc cca ttt tct gaa aat cag atc tgc ttg aca ttt      529
 Ile Glu Pro Lys Phe Pro Phe Ser Glu Asn Gln Ile Cys Leu Thr Phe
          80                  85                  90

 acc tgg aag gat gct ttc gat aaa ggt tca ctt ttt gga ggc tct gta      577
 Thr Trp Lys Asp Ala Phe Asp Lys Gly Ser Leu Phe Gly Gly Ser Val
      95                 100                 105

 aaa ctg gct ctt gca agc tta gga tat gaa aag agc tgt gtg ttg ttc      625
 Lys Leu Ala Leu Ala Ser Leu Gly Tyr Glu Lys Ser Cys Val Leu Phe
 110                 115                 120                 125

 aat tgt gca gcc tta gct agc caa att gca gca gaa cag aac ctg gat      673
 Asn Cys Ala Ala Leu Ala Ser Gln Ile Ala Ala Glu Gln Asn Leu Asp
                 130                 135                 140

 aat gat gaa gga ttg aaa atc gct gct aaa cat tac cag ttt gct agt      721
 Asn Asp Glu Gly Leu Lys Ile Ala Ala Lys His Tyr Gln Phe Ala Ser
             145                 150                 155

 ggt gcc ttt tta cat att aaa gag acg gtt tta tct gcc tta agt cga      769
 Gly Ala Phe Leu His Ile Lys Glu Thr Val Leu Ser Ala Leu Ser Arg
         160                 165                 170

 gag ccg acc gtg gac ata tct cca gat act gtt ggg acc ctc agt ctt      817
 Glu Pro Thr Val Asp Ile Ser Pro Asp Thr Val Gly Thr Leu Ser Leu
     175                 180                 185

 att atg ctg gca cag gct caa gaa gta ttt ttt tta aaa gcc aca aga      865
 Ile Met Leu Ala Gln Ala Gln Glu Val Phe Phe Leu Lys Ala Thr Arg
 190                 195                 200                 205

 gat aaa atg aaa gat gcc atc ata gct aaa ttg gct aat cag gct gca      913
 Asp Lys Met Lys Asp Ala Ile Ile Ala Lys Leu Ala Asn Gln Ala Ala
                 210                 215                 220

 gat tat ttt ggt gat gct ttc aaa cag tgt caa tac aaa gat act ctc      961
 Asp Tyr Phe Gly Asp Ala Phe Lys Gln Cys Gln Tyr Lys Asp Thr Leu
             225                 230                 235

 ccc aag gag gtg ttc cct gtc ttg gct gca aag cac tgt atc atg cag     1009
 Pro Lys Glu Val Phe Pro Val Leu Ala Ala Lys His Cys Ile Met Gln
         240                 245                 250

 gcc aat gct gag tac cat cag tct atc ctg gca aaa cag cag aag aaa     1057
 Ala Asn Ala Glu Tyr His Gln Ser Ile Leu Ala Lys Gln Gln Lys Lys
     255                 260                 265

 ttt gga gaa gaa att gca agg tta cag cat gca gca gaa ctg att aaa     1105
 Phe Gly Glu Glu Ile Ala Arg Leu Gln His Ala Ala Glu Leu Ile Lys
 270                 275                 280                 285

 aca gtg gca tct cgc tat gat gaa tat gtt aat gtg aag gat ttt tct     1153
 Thr Val Ala Ser Arg Tyr Asp Glu Tyr Val Asn Val Lys Asp Phe Ser
                 290                 295                 300

 gac aaa atc aat cgt gcc ctt gct gca gca aag aag gat aat gac ttc     1201
 Asp Lys Ile Asn Arg Ala Leu Ala Ala Ala Lys Lys Asp Asn Asp Phe
             305                 310                 315

 att tat cat gat cga gtt cca gac ctt aaa gat cta gat cct att ggc     1249
 Ile Tyr His Asp Arg Val Pro Asp Leu Lys Asp Leu Asp Pro Ile Gly
         320                 325                 330

 aaa gcc aca ctt gtg aaa tct acc ccg gtc aat gta ccc atc agt cag     1297
 Lys Ala Thr Leu Val Lys Ser Thr Pro Val Asn Val Pro Ile Ser Gln
     335                 340                 345

 aaa ttt act gat ctg ttt gag aag atg gtt ccc gtg tca gta cag cag     1345
 Lys Phe Thr Asp Leu Phe Glu Lys Met Val Pro Val Ser Val Gln Gln
 350                 355                 360                 365

 tct ttg gct gcc tat aat cag agg aaa gcc gat ttg att aac aga tca     1393
 Ser Leu Ala Ala Tyr Asn Gln Arg Lys Ala Asp Leu Ile Asn Arg Ser
                 370                 375                 380

 att gct cag atg aga gaa gcc acc act ttg gca aat ggg gtg cta gct     1441
 Ile Ala Gln Met Arg Glu Ala Thr Thr Leu Ala Asn Gly Val Leu Ala
             385                 390                 395

 tcc ctt aat ctt cca gca gca att gaa gat gtg tct gga gac act gta     1489
 Ser Leu Asn Leu Pro Ala Ala Ile Glu Asp Val Ser Gly Asp Thr Val
         400                 405                 410

 cct cag tct ata ttg act aaa tcc aga tct gtg att gaa cag gga ggc     1537
 Pro Gln Ser Ile Leu Thr Lys Ser Arg Ser Val Ile Glu Gln Gly Gly
     415                 420                 425

 atc cag act gtt gat cag ttg att aaa gaa ctg cct gaa tta ctg caa     1585
 Ile Gln Thr Val Asp Gln Leu Ile Lys Glu Leu Pro Glu Leu Leu Gln
 430                 435                 440                 445

 cga aat aga gaa atc cta gat gag tca tta agg ttg ttg gat gaa gaa     1633
 Arg Asn Arg Glu Ile Leu Asp Glu Ser Leu Arg Leu Leu Asp Glu Glu
                 450                 455                 460

 gaa gca acc gat aat gat tta aga gca aaa ttt aag gaa cgt tgg caa     1681
 Glu Ala Thr Asp Asn Asp Leu Arg Ala Lys Phe Lys Glu Arg Trp Gln
             465                 470                 475

 agg aca cca tcc aat gaa ctg tat aag cct tta aga gca gag gga acc     1729
 Arg Thr Pro Ser Asn Glu Leu Tyr Lys Pro Leu Arg Ala Glu Gly Thr
         480                 485                 490

 aac ttc aga aca gtt tta gat aaa gct gtg cag gca gat gga caa gtg     1777
 Asn Phe Arg Thr Val Leu Asp Lys Ala Val Gln Ala Asp Gly Gln Val
     495                 500                 505

 aaa gaa tgt tac cag tct cat cgt gac acc atc gtg ctt ttg tgt aag     1825
 Lys Glu Cys Tyr Gln Ser His Arg Asp Thr Ile Val Leu Leu Cys Lys
 510                 515                 520                 525

 cca gag cct gag ctg aat gct gcc atc cct tct gct aat cca gca aag     1873
 Pro Glu Pro Glu Leu Asn Ala Ala Ile Pro Ser Ala Asn Pro Ala Lys
                 530                 535                 540

 acc atg cag ggc agt gag gtt gta aat gtc tta aaa tcc tta ttg tca     1921
 Thr Met Gln Gly Ser Glu Val Val Asn Val Leu Lys Ser Leu Leu Ser
             545                 550                 555

 aat ctt gat gaa gta aag aag gaa aga gag ggt ctg gag aat gac ttg     1969
 Asn Leu Asp Glu Val Lys Lys Glu Arg Glu Gly Leu Glu Asn Asp Leu
         560                 565                 570

 aaa tct gtg aat ttt gac atg aca agc aag ttt ttg aca gcc ctg gct     2017
 Lys Ser Val Asn Phe Asp Met Thr Ser Lys Phe Leu Thr Ala Leu Ala
     575                 580                 585

 caa gat ggt gtg ata aat gaa gaa gct ctt tct gtt act gaa cta gat     2065
 Gln Asp Gly Val Ile Asn Glu Glu Ala Leu Ser Val Thr Glu Leu Asp
 590                 595                 600                 605

 cga gtc tat gga ggt ctt aca act aaa gtc caa gaa tct cta aag aaa     2113
 Arg Val Tyr Gly Gly Leu Thr Thr Lys Val Gln Glu Ser Leu Lys Lys
                 610                 615                 620

 cag gag gga ctt ctt aaa aat att cag gtc tca cat cag gaa ttt tca     2161
 Gln Glu Gly Leu Leu Lys Asn Ile Gln Val Ser His Gln Glu Phe Ser
             625                 630                 635

 aaa atg aaa caa tct aat aat gaa gct aac tta aga gaa gaa gtt ttg     2209
 Lys Met Lys Gln Ser Asn Asn Glu Ala Asn Leu Arg Glu Glu Val Leu
         640                 645                 650

 aag aat tta gct act gca tat gac aac ttt gtt gaa ctt gta gct aat     2257
 Lys Asn Leu Ala Thr Ala Tyr Asp Asn Phe Val Glu Leu Val Ala Asn
     655                 660                 665

 ttg aag gaa ggc aca aag ttt tac aat gag ttg act gaa atc ctg gtc     2305
 Leu Lys Glu Gly Thr Lys Phe Tyr Asn Glu Leu Thr Glu Ile Leu Val
 670                 675                 680                 685

 agg ttc cag aac aaa tgc agt gat ata gtt ttt gca cgg aag aca gaa     2353
 Arg Phe Gln Asn Lys Cys Ser Asp Ile Val Phe Ala Arg Lys Thr Glu
                 690                 695                 700

 aga gat gaa ctc tta aag gac ttg caa caa agc att gcc aga gaa cct     2401
 Arg Asp Glu Leu Leu Lys Asp Leu Gln Gln Ser Ile Ala Arg Glu Pro
             705                 710                 715

 agt gct cct tca att cct aca cct gcg tat cag tcc tta cca gca gga     2449
 Ser Ala Pro Ser Ile Pro Thr Pro Ala Tyr Gln Ser Leu Pro Ala Gly
         720                 725                 730

 gga cat gca cca act cct cca act cca gcg cca aga acc atg ccg cct     2497
 Gly His Ala Pro Thr Pro Pro Thr Pro Ala Pro Arg Thr Met Pro Pro
     735                 740                 745

 act aag ccc cag ccc cca gcc agg cct cca cca cct gtg ctt cca gca     2545
 Thr Lys Pro Gln Pro Pro Ala Arg Pro Pro Pro Pro Val Leu Pro Ala
 750                 755                 760                 765

 aat cga gct cct tct gct act gct cca tct cca gtg ggg gct ggg act     2593
 Asn Arg Ala Pro Ser Ala Thr Ala Pro Ser Pro Val Gly Ala Gly Thr
                 770                 775                 780

 gct gcg cca gct cca tca caa acg cct ggc tca gct cct cct cca cag     2641
 Ala Ala Pro Ala Pro Ser Gln Thr Pro Gly Ser Ala Pro Pro Pro Gln
             785                 790                 795

 gcg cag gga cca ccc tat ccc acc tat cca gga tat cct ggg tat tgc     2689
 Ala Gln Gly Pro Pro Tyr Pro Thr Tyr Pro Gly Tyr Pro Gly Tyr Cys
         800                 805                 810

 caa atg ccc atg ccc atg ggc tat aat cct tat gcg tat ggc cag tat     2737
 Gln Met Pro Met Pro Met Gly Tyr Asn Pro Tyr Ala Tyr Gly Gln Tyr
     815                 820                 825

 aat atg cca tat cca cca gtg tat cac cag agt cct gga cag gct cca     2785
 Asn Met Pro Tyr Pro Pro Val Tyr His Gln Ser Pro Gly Gln Ala Pro
 830                 835                 840                 845

 tac ccg gga ccc cag cag cct tca tac ccc ttc cct cag ccc cca cag     2833
 Tyr Pro Gly Pro Gln Gln Pro Ser Tyr Pro Phe Pro Gln Pro Pro Gln
                 850                 855                 860

 cag tct tac tat cca cag cag ta atatgtctgc tcagcagctc agctgattca     2886
 Gln Ser Tyr Tyr Pro Gln Gln 
             865

 gatcagaggg aaagaaatac caaccctgca ataagtgtac taaactctac gctctggtta   2946

 atgtaatgta ctctcctgga ctgaatgcag tgtataattt ctgtctacag ctagaagctg   3006

 tgccccagtt ccacatttga tta                                           3029




      <210> 64
      <211> 1985
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (18)..(1856)

      <400> 64
 gcgtcggggc tggagcg   atg gcg gcg acc gcg gtg gcg gcg gct gtg gcg      50
                      Met Ala Ala Thr Ala Val Ala Ala Ala Val Ala
                        1               5                  10

 gga acc gag tcg gcc cag ggt ccc ccg ggc ccg gca gcg tcg ctg gag       98
 Gly Thr Glu Ser Ala Gln Gly Pro Pro Gly Pro Ala Ala Ser Leu Glu
              15                  20                  25

 atc tgg ctg aac aaa gcc aca gac cca agc atg tcg gaa cag gat tgg      146
 Ile Trp Leu Asn Lys Ala Thr Asp Pro Ser Met Ser Glu Gln Asp Trp
          30                  35                  40

 tca gct atc cag aat ttc tgt gag cag gtg aac act gac ccc aat ggc      194
 Ser Ala Ile Gln Asn Phe Cys Glu Gln Val Asn Thr Asp Pro Asn Gly
      45                  50                  55

 ccc aca cat gcg ccc tgg cta ctg gcc cac aag atc cag tct ccg caa      242
 Pro Thr His Ala Pro Trp Leu Leu Ala His Lys Ile Gln Ser Pro Gln
  60                  65                  70                  75

 gag aag gaa gct ctt tat gcc tta acg gtg ctg gag atg tgc atg aac      290
 Glu Lys Glu Ala Leu Tyr Ala Leu Thr Val Leu Glu Met Cys Met Asn
                  80                  85                  90

 cac tgt ggg gag aag ttc cac agc gag gtg gcc aaa ttt cgt ttc ctg      338
 His Cys Gly Glu Lys Phe His Ser Glu Val Ala Lys Phe Arg Phe Leu
              95                 100                 105

 aac gaa ctg atc aaa gtg ttg tcc cca aag tac ctg ggg tcc tgg gcc      386
 Asn Glu Leu Ile Lys Val Leu Ser Pro Lys Tyr Leu Gly Ser Trp Ala
         110                 115                 120

 aca gga aaa gtt aaa gga aga gtc att gaa ata ctc ttc agt tgg aca      434
 Thr Gly Lys Val Lys Gly Arg Val Ile Glu Ile Leu Phe Ser Trp Thr
     125                 130                 135

 gtc tgg ttt ccg gaa gac atc aag att cga gac gct tat cag atg ctg      482
 Val Trp Phe Pro Glu Asp Ile Lys Ile Arg Asp Ala Tyr Gln Met Leu
 140                 145                 150                 155

 aag aaa caa gga att ata aaa caa gac cct aaa cta cca gtg gat aaa      530
 Lys Lys Gln Gly Ile Ile Lys Gln Asp Pro Lys Leu Pro Val Asp Lys
                 160                 165                 170

 atc tta ccc cca cca tct ccc tgg ccc aag agc tcc atc ttt gat gct      578
 Ile Leu Pro Pro Pro Ser Pro Trp Pro Lys Ser Ser Ile Phe Asp Ala
             175                 180                 185

 gat gaa gaa aag tcc aag ctt ctg aca agg ctt cta aag agc aac cac      626
 Asp Glu Glu Lys Ser Lys Leu Leu Thr Arg Leu Leu Lys Ser Asn His
         190                 195                 200

 ccc gag gac ctt cag gct gca aac cgg tta atc aag aat ttg gtc aag      674
 Pro Glu Asp Leu Gln Ala Ala Asn Arg Leu Ile Lys Asn Leu Val Lys
     205                 210                 215

 gag gaa caa gaa aaa tcg gag aag gtg tcc aag agg gtc agt gcg gtg      722
 Glu Glu Gln Glu Lys Ser Glu Lys Val Ser Lys Arg Val Ser Ala Val
 220                 225                 230                 235

 gag gaa gtg cga agc cat gtg aag gtg ctg cag gag atg ctg agc atg      770
 Glu Glu Val Arg Ser His Val Lys Val Leu Gln Glu Met Leu Ser Met
                 240                 245                 250

 tac cgc agg cca ggg cag gcc ccg ccc gac cag gag gcc ctg cag gtc      818
 Tyr Arg Arg Pro Gly Gln Ala Pro Pro Asp Gln Glu Ala Leu Gln Val
             255                 260                 265

 gtg tat gag agg tgt gaa aag ctg cgg ccc acg ctg ttc cgg ttg gcg      866
 Val Tyr Glu Arg Cys Glu Lys Leu Arg Pro Thr Leu Phe Arg Leu Ala
         270                 275                 280

 agt gac acc act gat gac gat gat gca ctc gcg gaa att ctc cag gca      914
 Ser Asp Thr Thr Asp Asp Asp Asp Ala Leu Ala Glu Ile Leu Gln Ala
     285                 290                 295

 aat gac ctc ctc acc caa gga gtt ctg ctg tac aaa cag gtg atg gag      962
 Asn Asp Leu Leu Thr Gln Gly Val Leu Leu Tyr Lys Gln Val Met Glu
 300                 305                 310                 315

 ggc cgg gtc acc ttt gga aac aga gtg acc agc tca ttg gga gac atc     1010
 Gly Arg Val Thr Phe Gly Asn Arg Val Thr Ser Ser Leu Gly Asp Ile
                 320                 325                 330

 cct gtc tcc aga gtc ttt cag aat cca gca ggc tgc atg aag acc tgc     1058
 Pro Val Ser Arg Val Phe Gln Asn Pro Ala Gly Cys Met Lys Thr Cys
             335                 340                 345

 ccc ctg att gac ttg gag gtg gac aat gga cct gcg cag atg ggg act     1106
 Pro Leu Ile Asp Leu Glu Val Asp Asn Gly Pro Ala Gln Met Gly Thr
         350                 355                 360

 gtg gtg cca tct ttg ctt cat cag gac ctg gca gcc ttg gga atc agt     1154
 Val Val Pro Ser Leu Leu His Gln Asp Leu Ala Ala Leu Gly Ile Ser
     365                 370                 375

 gat gct cct gtt aca ggc atg gtt tct ggt cag aat tgc tgt gag gaa     1202
 Asp Ala Pro Val Thr Gly Met Val Ser Gly Gln Asn Cys Cys Glu Glu
 380                 385                 390                 395

 aag agg aat ccc tcc tcc agc acg ctg cca ggc ggt ggt gtt cag aac     1250
 Lys Arg Asn Pro Ser Ser Ser Thr Leu Pro Gly Gly Gly Val Gln Asn
                 400                 405                 410

 cct tct gca gac agg aat ttg ctg gac ctc ctc tca cca cag cca gct     1298
 Pro Ser Ala Asp Arg Asn Leu Leu Asp Leu Leu Ser Pro Gln Pro Ala
             415                 420                 425

 ccg tgc cct ctg aat tat gtt tcg cag aaa agt gtc ccc aag gaa gtg     1346
 Pro Cys Pro Leu Asn Tyr Val Ser Gln Lys Ser Val Pro Lys Glu Val
         430                 435                 440

 cca cca ggt act aag tcc tct cca ggt tgg tcc tgg gag gct ggc ccg     1394
 Pro Pro Gly Thr Lys Ser Ser Pro Gly Trp Ser Trp Glu Ala Gly Pro
     445                 450                 455

 ttg gct cct tcc cca tct tca cag aat aca cct ctg gct caa gtg ttt     1442
 Leu Ala Pro Ser Pro Ser Ser Gln Asn Thr Pro Leu Ala Gln Val Phe
 460                 465                 470                 475

 gtc cct ttg gag tct gtt aag ccc agc agc ctg ccg cct ctc att gtg     1490
 Val Pro Leu Glu Ser Val Lys Pro Ser Ser Leu Pro Pro Leu Ile Val
                 480                 485                 490

 tat gac cgg aat gga ttc aga att ctg ctc cac ttc tcc cag acg gga     1538
 Tyr Asp Arg Asn Gly Phe Arg Ile Leu Leu His Phe Ser Gln Thr Gly
             495                 500                 505

 gcc cct ggg cac cca gag gta cag gtg ctg ctc ttg acc atg atg agc     1586
 Ala Pro Gly His Pro Glu Val Gln Val Leu Leu Leu Thr Met Met Ser
         510                 515                 520

 acg gct ccc cag cct gtc tgg gat atc atg ttt caa gtg gct gtg cca     1634
 Thr Ala Pro Gln Pro Val Trp Asp Ile Met Phe Gln Val Ala Val Pro
     525                 530                 535

 aag tca atg aga gtg aag ctg cag ccg gca tcc agc tcc aag ctt cct     1682
 Lys Ser Met Arg Val Lys Leu Gln Pro Ala Ser Ser Ser Lys Leu Pro
 540                 545                 550                 555

 gca ttc agt cct ttg atg cct cca gct gtg ata tct cag atg ctg ctg     1730
 Ala Phe Ser Pro Leu Met Pro Pro Ala Val Ile Ser Gln Met Leu Leu
                 560                 565                 570

 ctt gac aat cca cac aaa gaa cct atc cgc tta cgg tac aag ctg aca     1778
 Leu Asp Asn Pro His Lys Glu Pro Ile Arg Leu Arg Tyr Lys Leu Thr
             575                 580                 585

 ttc aac caa ggt gga cag cct ttc agc gaa gta gga gaa gtg aaa gac     1826
 Phe Asn Gln Gly Gly Gln Pro Phe Ser Glu Val Gly Glu Val Lys Asp
         590                 595                 600

 ttc cca gac ctg gct gtc ttg ggc gca gcc t aacttttcac aagatggacc     1877
 Phe Pro Asp Leu Ala Val Leu Gly Ala Ala 
     605                 610

 cttcatttca agcttaggct ggcgttactt ttgctgtcta gtcaggacta atcacggtgt   1937

 ttcagtgcgg agtgccaaga gtcctatcct gacgtcaaaa aaaaaaaa                1985




      <210> 65
      <211> 2045
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (97)..(1683)

      <400> 65
 gccctccgtg gacaattgtg ttgaagcaga aattgttccg gatctcgggt cggacacgga     60

 agtcttcctg cagtgtttct ggatgcgggg acaggg  atg cgc agg aat tcc agt     114
                                          Met Arg Arg Asn Ser Ser
                                            1               5

 ctc agt ttc cag atg gag cga ccc ctc gag gag caa gtc cag agc aag      162
 Leu Ser Phe Gln Met Glu Arg Pro Leu Glu Glu Gln Val Gln Ser Lys
              10                  15                  20

 tgg tcg tct agt caa ggc cgc aca gga aca gga ggg tct gat gtc ctc      210
 Trp Ser Ser Ser Gln Gly Arg Thr Gly Thr Gly Gly Ser Asp Val Leu
          25                  30                  35

 cag atg cag aac agt gaa cac cat gga caa agc atc aag act caa act      258
 Gln Met Gln Asn Ser Glu His His Gly Gln Ser Ile Lys Thr Gln Thr
      40                  45                  50

 gac tcc atc tcc ctt gag gat gtg gct gtg aac ttc acc ctg gag gag      306
 Asp Ser Ile Ser Leu Glu Asp Val Ala Val Asn Phe Thr Leu Glu Glu
  55                  60                  65                  70

 tgg gct ttg ctg gat cct ggc cag agg aat atc tac aga gat gtg atg      354
 Trp Ala Leu Leu Asp Pro Gly Gln Arg Asn Ile Tyr Arg Asp Val Met
                  75                  80                  85

 cgg gca acc ttc aag aac ctg gcc tgt ata ggg gaa aaa tgg aaa gac      402
 Arg Ala Thr Phe Lys Asn Leu Ala Cys Ile Gly Glu Lys Trp Lys Asp
              90                  95                 100

 cag gat att gaa gat gaa cac aaa aac cag gga aga aat cta aga agt      450
 Gln Asp Ile Glu Asp Glu His Lys Asn Gln Gly Arg Asn Leu Arg Ser
         105                 110                 115

 cct atg gtt gaa gca ctc tgt gaa aat aaa gaa gat tgt cca tgt gga      498
 Pro Met Val Glu Ala Leu Cys Glu Asn Lys Glu Asp Cys Pro Cys Gly
     120                 125                 130

 aaa agc act agc cag att cct gat ctt aat acg aac ctg gaa act cct      546
 Lys Ser Thr Ser Gln Ile Pro Asp Leu Asn Thr Asn Leu Glu Thr Pro
 135                 140                 145                 150

 act gga tta aaa cca tgt gac tgc agt gtg tgt ggg gaa gtc ttc atg      594
 Thr Gly Leu Lys Pro Cys Asp Cys Ser Val Cys Gly Glu Val Phe Met
                 155                 160                 165

 cat cag gtc tcc ctt aat agg cac atg aga tct cac act gaa cag aaa      642
 His Gln Val Ser Leu Asn Arg His Met Arg Ser His Thr Glu Gln Lys
             170                 175                 180

 cca aat gag tgt cac gaa tat gga gag aag cca cat aaa tgc aaa gaa      690
 Pro Asn Glu Cys His Glu Tyr Gly Glu Lys Pro His Lys Cys Lys Glu
         185                 190                 195

 tgt ggg aaa acc ttc act cgc agc tcc agt att cga acc cat gaa aga      738
 Cys Gly Lys Thr Phe Thr Arg Ser Ser Ser Ile Arg Thr His Glu Arg
     200                 205                 210

 att cac act gga gag aaa ccc tat gaa tgt aag gaa tgt ggc aaa gcc      786
 Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala
 215                 220                 225                 230

 ttc gca ttt ctc ttt tcc ttt cga aac cat ata aga att cat act gga      834
 Phe Ala Phe Leu Phe Ser Phe Arg Asn His Ile Arg Ile His Thr Gly
                 235                 240                 245

 gag aca ccc tat gaa tgt aag gaa tgt ggg aag gca ttc aga tat ctc      882
 Glu Thr Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Arg Tyr Leu
             250                 255                 260

 act gct ctt cgg cgc cat gaa aaa aat cac act gga gag aaa ccc tac      930
 Thr Ala Leu Arg Arg His Glu Lys Asn His Thr Gly Glu Lys Pro Tyr
         265                 270                 275

 aaa tgt aaa cag tgt gga aaa gcc ttt ata tat tac cag cct ttt cta      978
 Lys Cys Lys Gln Cys Gly Lys Ala Phe Ile Tyr Tyr Gln Pro Phe Leu
     280                 285                 290

 acc cac gaa agg act cac act gga gag aaa cct tat gaa tgt aag caa     1026
 Thr His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln
 295                 300                 305                 310

 tgt ggg aaa gcc ttc agt tgt ccc acg tac tta cgg agt cat gag aaa     1074
 Cys Gly Lys Ala Phe Ser Cys Pro Thr Tyr Leu Arg Ser His Glu Lys
                 315                 320                 325

 act cat act gga gag aaa cct ttt gta tgt agg gaa tgt ggg aga gcc     1122
 Thr His Thr Gly Glu Lys Pro Phe Val Cys Arg Glu Cys Gly Arg Ala
             330                 335                 340

 ttc ttt tct cac tca agc ctt cga aaa cac gtg aaa acc cac acc gga     1170
 Phe Phe Ser His Ser Ser Leu Arg Lys His Val Lys Thr His Thr Gly
         345                 350                 355

 gtt caa cct tat aca tgt aag aaa tgt ggg gaa gcc ttc aag tca tct     1218
 Val Gln Pro Tyr Thr Cys Lys Lys Cys Gly Glu Ala Phe Lys Ser Ser
     360                 365                 370

 agt tcc tgt gaa gtg cac gaa aga act cat ttt gga gaa aaa ccc tat     1266
 Ser Ser Cys Glu Val His Glu Arg Thr His Phe Gly Glu Lys Pro Tyr
 375                 380                 385                 390

 gaa tgt aaa caa tgt ggt aaa gcc ttc aat tct tca agt tac ctt cag     1314
 Glu Cys Lys Gln Cys Gly Lys Ala Phe Asn Ser Ser Ser Tyr Leu Gln
                 395                 400                 405

 ttg cac gaa aga gtt cac act ggc gag aaa act tac gaa tgt aaa gaa     1362
 Leu His Glu Arg Val His Thr Gly Glu Lys Thr Tyr Glu Cys Lys Glu
             410                 415                 420

 tgt ggt aaa gcc ttt ctt tat tcc act cac ttt cga atc cat gaa aga     1410
 Cys Gly Lys Ala Phe Leu Tyr Ser Thr His Phe Arg Ile His Glu Arg
         425                 430                 435

 acc cat act aga gag aaa ccc tat gaa tgc aaa cag tgt ggt cgg gtc     1458
 Thr His Thr Arg Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Arg Val
     440                 445                 450

 ttc att tac ttc agt cac ctt cga agg cac gaa aga agt cac act gga     1506
 Phe Ile Tyr Phe Ser His Leu Arg Arg His Glu Arg Ser His Thr Gly
 455                 460                 465                 470

 gtg aaa cca tgt gag tgt aag cag tgt ggc aaa gct ttc act tgt tta     1554
 Val Lys Pro Cys Glu Cys Lys Gln Cys Gly Lys Ala Phe Thr Cys Leu
                 475                 480                 485

 aat tcc ctg aaa gta cac aaa aga att cat act gga gaa aga ccc ttt     1602
 Asn Ser Leu Lys Val His Lys Arg Ile His Thr Gly Glu Arg Pro Phe
             490                 495                 500

 cag tgt aga caa tgt ggt aaa gcc ttc agt tac tca aag tct ttg cac     1650
 Gln Cys Arg Gln Cys Gly Lys Ala Phe Ser Tyr Ser Lys Ser Leu His
         505                 510                 515

 gtg cac gaa agg act cat agt aga cag aag ccc taagaaag taaagtgtgg     1701
 Val His Glu Arg Thr His Ser Arg Gln Lys Pro 
     520                 525

 taatgctgtc agttgtatta gttccttttg gatgtatgag agtacttacg ctggagagaa   1761

 attcaaggaa tgtaaacggt gtgattaagc cttcagttgt cctaattccc tttgaagacg   1821

 tgactcatgc ggcaatgaaa tatttaacaa atgggggagg aacttgcact ctcctgcggg   1881

 attgcagata cgtgaatgga ctccatggac agaaaagcta cgaatgtatg gagtgtagga   1941

 aagccttcac ttcacgtaat cttttaaaga cacctgagaa tatatactgg agagaaacta   2001

 taaagaaaat tctatatcca tcccatcttt tgtggagttt ggtt                    2045




      <210> 66
      <211> 1525
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (60)..(1346)

      <400> 66
 ctcctgctac ctccctttcc ggcacccttc agagggaccc tcagtctggc cttgcaagc      59                                                                 
 atg gac tct tct gag gag cac gct ggg tgc ccc gcc cga ggg aca tgt      107
 Met Asp Ser Ser Glu Glu His Ala Gly Cys Pro Ala Arg Gly Thr Cys
   1               5                  10                  15

 ccc gtg ttc ctg gcc atg agt gca ggg act gtc cgc tac gcc cca tca      155
 Pro Val Phe Leu Ala Met Ser Ala Gly Thr Val Arg Tyr Ala Pro Ser
              20                  25                  30

 ggc ctg tgc cct gta ctt gag ggg aac ttg aga gaa gag ccc tgg ggc      203
 Gly Leu Cys Pro Val Leu Glu Gly Asn Leu Arg Glu Glu Pro Trp Gly
          35                  40                  45

 aca gac agc cca ccc cag cca gac cag ggc ctc ccg ccg ccc ctt gca      251
 Thr Asp Ser Pro Pro Gln Pro Asp Gln Gly Leu Pro Pro Pro Leu Ala
      50                  55                  60

 gct gtc ccg gtc ccc tgg aag agc acg gac ccc tgc caa ggc cac agg      299
 Ala Val Pro Val Pro Trp Lys Ser Thr Asp Pro Cys Gln Gly His Arg
  65                  70                  75                  80

 gag tcc cca gga gcc ctg gtg gag acc tct gca ggg gag gag gcc caa      347
 Glu Ser Pro Gly Ala Leu Val Glu Thr Ser Ala Gly Glu Glu Ala Gln
                  85                  90                  95

 ggc cag gag ggc ccc gca gcc gcc cag ctg gac gtg ttg cgc ctg cgc      395
 Gly Gln Glu Gly Pro Ala Ala Ala Gln Leu Asp Val Leu Arg Leu Arg
             100                 105                 110

 agc tct tcc atg gag atc cga gag aag ggc tcc gag ttc ctg aag gag      443
 Ser Ser Ser Met Glu Ile Arg Glu Lys Gly Ser Glu Phe Leu Lys Glu
         115                 120                 125

 gag ctg cac aga gcg cag aag gag ctg aag cta aag gac gag gaa tgt      491
 Glu Leu His Arg Ala Gln Lys Glu Leu Lys Leu Lys Asp Glu Glu Cys
     130                 135                 140

 gag cgg ctg tcc aag gtg cgg gag cag cta gaa cag gag ctg gaa gag      539
 Glu Arg Leu Ser Lys Val Arg Glu Gln Leu Glu Gln Glu Leu Glu Glu
 145                 150                 155                 160

 ctg acg gcc agc ctg ttt gag gaa gct cac aag atg gtt cga gaa gcc      587
 Leu Thr Ala Ser Leu Phe Glu Glu Ala His Lys Met Val Arg Glu Ala
                 165                 170                 175

 aac atg aag cag gcg gca tca gaa aag cag ctg aag gag gct cgg ggc      635
 Asn Met Lys Gln Ala Ala Ser Glu Lys Gln Leu Lys Glu Ala Arg Gly
             180                 185                 190

 aag atc gac atg ctg cag gca gag gtg aca gcc ttg aag acg ctg gtc      683
 Lys Ile Asp Met Leu Gln Ala Glu Val Thr Ala Leu Lys Thr Leu Val
         195                 200                 205

 atc acg tcc aca cca gcc tct ccc aac cgc gag ctt cac ccc cag ctg      731
 Ile Thr Ser Thr Pro Ala Ser Pro Asn Arg Glu Leu His Pro Gln Leu
     210                 215                 220

 ctg agc ccc acc aag gcc ggg ccc cga aag ggc cac tct cgc cac aag      779
 Leu Ser Pro Thr Lys Ala Gly Pro Arg Lys Gly His Ser Arg His Lys
 225                 230                 235                 240

 agc acc agc agc acc ctc tgc ccc gcc gtg tgt ccc gct gcg gga cac      827
 Ser Thr Ser Ser Thr Leu Cys Pro Ala Val Cys Pro Ala Ala Gly His
                 245                 250                 255

 acc ctc acc cca tac aga gag ggc aag gag gtg gac aca atc ctg ttt      875
 Thr Leu Thr Pro Tyr Arg Glu Gly Lys Glu Val Asp Thr Ile Leu Phe
             260                 265                 270

 gca gag ttc cag gcc tgg agg gaa tcc ccc acc ctg gac aag acc tgc      923
 Ala Glu Phe Gln Ala Trp Arg Glu Ser Pro Thr Leu Asp Lys Thr Cys
         275                 280                 285

 ccc ttc ctg gaa agg gtg tac cga gag gac gtg ggc ccc tgc ctg gac      971
 Pro Phe Leu Glu Arg Val Tyr Arg Glu Asp Val Gly Pro Cys Leu Asp
     290                 295                 300

 ttc aca atg cag gag ctc tcg gtg ctg gta cgg gcc gcc gtg gag gac     1019
 Phe Thr Met Gln Glu Leu Ser Val Leu Val Arg Ala Ala Val Glu Asp
 305                 310                 315                 320

 aac acg ccc acc att gag ccg gtg gct tcg cag acg ctg ccc aca gtg     1067
 Asn Thr Pro Thr Ile Glu Pro Val Ala Ser Gln Thr Leu Pro Thr Val
                 325                 330                 335

 aag gtg gcc gag gtt gac tgt agc agc acc aac aca tgt gcc ctg agc     1115
 Lys Val Ala Glu Val Asp Cys Ser Ser Thr Asn Thr Cys Ala Leu Ser
             340                 345                 350

 ggg ctg acc cgc acc tgc cgc cac cga atc cgg ctc ggg gac tcc aaa     1163
 Gly Leu Thr Arg Thr Cys Arg His Arg Ile Arg Leu Gly Asp Ser Lys
         355                 360                 365

 agc cat tac tac atc tcg cca tct tcc cgg gcc agg atc acc gca gtg     1211
 Ser His Tyr Tyr Ile Ser Pro Ser Ser Arg Ala Arg Ile Thr Ala Val
     370                 375                 380

 tgc aac ttc ttc acc tac atc cgc tac atc cag caa ggc ctg gtg cgg     1259
 Cys Asn Phe Phe Thr Tyr Ile Arg Tyr Ile Gln Gln Gly Leu Val Arg
 385                 390                 395                 400

 cag gac gca gag ccc atg ttc tgg gag atc atg agg ttg cgg aag gag     1307
 Gln Asp Ala Glu Pro Met Phe Trp Glu Ile Met Arg Leu Arg Lys Glu
                 405                 410                 415

 atg tca ctg gcc aag ctc ggc ttc ttc ccc cag gag gct tagggcgcgg      1356
 Met Ser Leu Ala Lys Leu Gly Phe Phe Pro Gln Glu Ala 
             420                 425

 cccaggcctg aaggggagct ctgagacaga gcaaacaccc accccagaac aagccgacac   1416

 acagggagac gggggcctgg agccagccct gagccagagg cagaatggat ggacagacag   1476

 gccatggagg cagcactgag ccagcaccac acgtccatcc tgggacaga               1525




      <210> 67
      <211> 1356
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (206)..(565)

      <400> 67
 aggacctact agcaactaaa agggagcgtt gagcgtaaag ggaactagct tgcggccgca     60

 aatctttttt tttttttttt tttgtcgatt tgatcttctt ttttgagagt cttgatcttt    120

 taatgtatgc tgtggcatct gttctgcatc agatatttca tctgaagact cattctttct    180

 tttttgtttc ttacccaatg taata  atg agt ttg cca att ttt gtc ttc tct     232
                              Met Ser Leu Pro Ile Phe Val Phe Ser
                                1               5

 ttt aac tta gaa cat gtt ttt gtt ttt ttg ctg tct ttg tcc ttt ggc      280
 Phe Asn Leu Glu His Val Phe Val Phe Leu Leu Ser Leu Ser Phe Gly
  10                  15                  20                  25

 ttg gat ttc atc ctt cta cct ttc ttt tcc tct ttt cct tca act gaa      328
 Leu Asp Phe Ile Leu Leu Pro Phe Phe Ser Ser Phe Pro Ser Thr Glu
                  30                  35                  40

 gca gta gga aag ttt tca ggg ctc att act cgt gga ata ttg cgt tcc      376
 Ala Val Gly Lys Phe Ser Gly Leu Ile Thr Arg Gly Ile Leu Arg Ser
              45                  50                  55

 cca cgc tcc ttt gct ttt gct atg gcc tct gat att ata cga tta gcc      424
 Pro Arg Ser Phe Ala Phe Ala Met Ala Ser Asp Ile Ile Arg Leu Ala
          60                  65                  70

 ttt tct tgc ttg ctt tct gat tcc acc ttt ttt ctc tgc ttc ttc tca      472
 Phe Ser Cys Leu Leu Ser Asp Ser Thr Phe Phe Leu Cys Phe Phe Ser
      75                  80                  85

 gac atg acc ctc acc tgg gta ttc tgc aac tta gta tat gtc cca gaa      520
 Asp Met Thr Leu Thr Trp Val Phe Cys Asn Leu Val Tyr Val Pro Glu
  90                  95                 100                 105

 cca tcg ctc ttc ttg gaa gat gga ggc tgt cgc tgt aaa cat agg tga      568
 Pro Ser Leu Phe Leu Glu Asp Gly Gly Cys Arg Cys Lys His Arg 
                 110                 115                 120

 tttctgtcat gtaaatgctg atgattagaa aatgatgaat gccaactccg agcctgactt    628

 tgcaactgag tctgagccat atcagaaggc cgtgttacca gatgcgaagt aaactgccga    688

 tcaaggtcat gatctaaaat gtgacttgaa ttatcttgtc cgaatgttga ctcatcaaag    748

 tgaggaagaa gaccctcctg aaggaggtcc tcggggtcaa gtcctgtgaa tggctcagtt    808

 tgagattcca cttgatgaag taaattctct tctaaagatg aaaagccatt agtttctaca    868

 tgatcattga aatggcccat ttgagttcct gagtcaacag gatctgggaa gttcatgtgc    928

 acaggagata attttgaatt gctataatta ccctgaggat gtgatgaatg caatatttgg    988

 aaattatttg aattcaatga tgtattgggg tttaggatat gctgagtaga ttcttgcttg   1048

 attcctctat gaggtgaaaa ggaattactt ccagtaaaat cagataaagt ctgatttgta   1108

 tgattagatg caagaactgc agaggactga agtagactgt ttggtgatat atgattactg   1168

 gaaaaggaat aatgtgaaga aaattgctgt gaattactga cagaacaaga agtcatattt   1228

 ggggaaggtc cattaaaatt tccttcttga tgactgctac acttgtggaa gtgtgctgaa   1288

 ggatttgacg tttgagaaaa ttgctgcatt gaaatagact gttgtgaatt agatgcatta   1348

 gtcatctg                                                            1356




      <210> 68
      <211> 1366
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (184)..(1284)

      <400> 68
 gagccaggag cgagtgggtg acaggtcatt ggtgactggg gaggttgctt gacaagtcag     60

 gattgtgcct ccagtcagaa ggaccatgaa gagagagaag agggcagagc cgtgcatggg    120

 gctgctcccc aggacctgag caggaacctg gagttttcag agctgcctga tcattgctac    180

 aga  atg aac tct agc cca gct ggg acc cca agt cca cag ccc tcc agg     228
      Met Asn Ser Ser Pro Ala Gly Thr Pro Ser Pro Gln Pro Ser Arg
        1               5                  10                  15

 gcc aat ggg aac atc aac ctg ggg cct tca gcc aac cca aat gcc cag      276
 Ala Asn Gly Asn Ile Asn Leu Gly Pro Ser Ala Asn Pro Asn Ala Gln
                  20                  25                  30

 ccc acg gac ttc gac ttc ctc aaa gtc atc ggc aaa ggg aac tac ggg      324
 Pro Thr Asp Phe Asp Phe Leu Lys Val Ile Gly Lys Gly Asn Tyr Gly
              35                  40                  45

 aag gtc cta ctg gcc aag cgc aag tct gat ggg gcg ttc tat gca gtg      372
 Lys Val Leu Leu Ala Lys Arg Lys Ser Asp Gly Ala Phe Tyr Ala Val
          50                  55                  60

 aag gta cta cag aaa aag tcc atc tta aag aag aaa gag cag agc cac      420
 Lys Val Leu Gln Lys Lys Ser Ile Leu Lys Lys Lys Glu Gln Ser His
      65                  70                  75

 atc atg gca gag cgc agt gtg ctt ctg aag aac gtg cgg cac ccc ttc      468
 Ile Met Ala Glu Arg Ser Val Leu Leu Lys Asn Val Arg His Pro Phe
  80                  85                  90                  95

 ctc gtg ggc ctg cgc tac tcc ttc cag aca cct gag aag ctc tac ttc      516
 Leu Val Gly Leu Arg Tyr Ser Phe Gln Thr Pro Glu Lys Leu Tyr Phe
                 100                 105                 110

 gtg ctc gac tat gtc aac ggg gga gag ctc ttc ttc cac ctg cag cgg      564
 Val Leu Asp Tyr Val Asn Gly Gly Glu Leu Phe Phe His Leu Gln Arg
             115                 120                 125

 gag cgc cgg ttc ctg gag ccc cgg gcc agg ttc tac gct gct gag gtg      612
 Glu Arg Arg Phe Leu Glu Pro Arg Ala Arg Phe Tyr Ala Ala Glu Val
         130                 135                 140

 gcc agc gcc att ggc tac ctg cac tcc ctc aac atc att tac agg gat      660
 Ala Ser Ala Ile Gly Tyr Leu His Ser Leu Asn Ile Ile Tyr Arg Asp
     145                 150                 155

 ctg aaa cca gag aac att ctc ttg gac tgc cag gga cac gtg gtg ctg      708
 Leu Lys Pro Glu Asn Ile Leu Leu Asp Cys Gln Gly His Val Val Leu
 160                 165                 170                 175

 acg gat ttt ggc ctc tgc aag gaa ggt gta gag cct gaa gac acc aca      756
 Thr Asp Phe Gly Leu Cys Lys Glu Gly Val Glu Pro Glu Asp Thr Thr
                 180                 185                 190

 tcc aca ttc tgt ggt acc cct gag tac ttg gca cct gaa gtg ctt cgg      804
 Ser Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu Arg
             195                 200                 205

 aaa gag cct tat gat cga gca gtg gac tgg tgg tgc ttg ggg gca gtc      852
 Lys Glu Pro Tyr Asp Arg Ala Val Asp Trp Trp Cys Leu Gly Ala Val
         210                 215                 220

 ctc tac gag atg ctc cat ggc ctg ccg ccc ttc tac agc caa gat gta      900
 Leu Tyr Glu Met Leu His Gly Leu Pro Pro Phe Tyr Ser Gln Asp Val
     225                 230                 235

 tcc cag atg tat gag aac att ctg cac cag ccg cta cag atc ccc gga      948
 Ser Gln Met Tyr Glu Asn Ile Leu His Gln Pro Leu Gln Ile Pro Gly
 240                 245                 250                 255

 ggc cgg aca gtg gcc gcc tgt gac ctc ctg caa agc ctt ctc cac aag      996
 Gly Arg Thr Val Ala Ala Cys Asp Leu Leu Gln Ser Leu Leu His Lys
                 260                 265                 270

 gac cag agg cag cgg ctg ggc tcc aaa gca gac ttt ctt gag att aag     1044
 Asp Gln Arg Gln Arg Leu Gly Ser Lys Ala Asp Phe Leu Glu Ile Lys
             275                 280                 285

 aac cat gta ttc ttc agc ccc ata aac tgg gat gac ctg tac cac aag     1092
 Asn His Val Phe Phe Ser Pro Ile Asn Trp Asp Asp Leu Tyr His Lys
         290                 295                 300

 agg cta act cca ccc ttc aac cca aat gtg aca gga cct gct gac ttg     1140
 Arg Leu Thr Pro Pro Phe Asn Pro Asn Val Thr Gly Pro Ala Asp Leu
     305                 310                 315

 aag cat ttt gac cca gag ttc acc cag gaa gct gtg tcc aag tcc att     1188
 Lys His Phe Asp Pro Glu Phe Thr Gln Glu Ala Val Ser Lys Ser Ile
 320                 325                 330                 335

 ggc tgt acc cct gac act gtg gcc agc agc tct ggg gcc tca agt gca     1236
 Gly Cys Thr Pro Asp Thr Val Ala Ser Ser Ser Gly Ala Ser Ser Ala
                 340                 345                 350

 ttc ctg gga ttt tct tat gcg cca gag gat gat gac atc ttg gat tgc     1284
 Phe Leu Gly Phe Ser Tyr Ala Pro Glu Asp Asp Asp Ile Leu Asp Cys 
             355                 360                 365

 tagaagagaa ggacctgtga aactactgag gccagctggt attagtaagg aattaccttc   1344

 agctgctagg aagagctgta tt                                            1366




      <210> 69
      <211> 7747
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (41)..(7414)

      <400> 69
 acatgtgact ttaccctctt cccctcgaag caacactcca  atg gga gac aag gat      55
                                              Met Gly Asp Lys Asp
                                                1               5

 gat gat gac gat gat gat gca gat gag aaa atg cag tca tca ggg atc      103
 Asp Asp Asp Asp Asp Asp Ala Asp Glu Lys Met Gln Ser Ser Gly Ile
                  10                  15                  20

 ccg aat ggt ggt cac atc cgt cag gaa agc cag gaa cag agt gag gtg      151
 Pro Asn Gly Gly His Ile Arg Gln Glu Ser Gln Glu Gln Ser Glu Val
              25                  30                  35

 gac cat gga gat ttt gag atg gtg tct gag tcg atg gtc ctg gag aca      199
 Asp His Gly Asp Phe Glu Met Val Ser Glu Ser Met Val Leu Glu Thr
          40                  45                  50

 gct gaa aat gtc aac aat ggc aac ccc tct ccc ctg gag gcc ctg ctg      247
 Ala Glu Asn Val Asn Asn Gly Asn Pro Ser Pro Leu Glu Ala Leu Leu
      55                  60                  65

 gca ggc gca gag ggc ttc ccc ccc atg ctg gac atc cca cct gat gca      295
 Ala Gly Ala Glu Gly Phe Pro Pro Met Leu Asp Ile Pro Pro Asp Ala
  70                  75                  80                  85

 gat gac gag acc atg gtt gaa cta gcc att gcc ctg agc ctg cag cag      343
 Asp Asp Glu Thr Met Val Glu Leu Ala Ile Ala Leu Ser Leu Gln Gln
                  90                  95                 100

 gac caa caa ggc agc agc agc agt gcc ctg ggc ctg cag agc ctg gga      391
 Asp Gln Gln Gly Ser Ser Ser Ser Ala Leu Gly Leu Gln Ser Leu Gly
             105                 110                 115

 ctg tcc ggc cag gca ccc agc tct tcc tct ctg gac gca gga acc ctc      439
 Leu Ser Gly Gln Ala Pro Ser Ser Ser Ser Leu Asp Ala Gly Thr Leu
         120                 125                 130

 tct gac acc aca gca tca gct cca gcc tca gac gac gag ggc agt aca      487
 Ser Asp Thr Thr Ala Ser Ala Pro Ala Ser Asp Asp Glu Gly Ser Thr
     135                 140                 145

 gca gcg aca gat ggt tct acc ctt cgg acc tct cct gct gac cac ggt      535
 Ala Ala Thr Asp Gly Ser Thr Leu Arg Thr Ser Pro Ala Asp His Gly
 150                 155                 160                 165

 ggt agt gtg ggc tcg gag agc ggg ggc agt gca gtg gac tca gtg gct      583
 Gly Ser Val Gly Ser Glu Ser Gly Gly Ser Ala Val Asp Ser Val Ala
                 170                 175                 180

 ggc gag cac agt gta tct ggc cgg agc agt gct tat ggc gat gct aca      631
 Gly Glu His Ser Val Ser Gly Arg Ser Ser Ala Tyr Gly Asp Ala Thr
             185                 190                 195

 gct gag ggg cat ccg gct gga cca gga agt gtc agc tca agc act gga      679
 Ala Glu Gly His Pro Ala Gly Pro Gly Ser Val Ser Ser Ser Thr Gly
         200                 205                 210

 gcc atc agc acc acc act ggg cac cag gag gga gat ggc tcc gag gga      727
 Ala Ile Ser Thr Thr Thr Gly His Gln Glu Gly Asp Gly Ser Glu Gly
     215                 220                 225

 gaa gga gaa gga gaa act gaa gga gat gtc cac act agc aac agg ctg      775
 Glu Gly Glu Gly Glu Thr Glu Gly Asp Val His Thr Ser Asn Arg Leu
 230                 235                 240                 245

 cac atg gtc cgt cta atg ctg ttg gag aga tta ctg cag acc ctg cct      823
 His Met Val Arg Leu Met Leu Leu Glu Arg Leu Leu Gln Thr Leu Pro
                 250                 255                 260

 caa tta cga aac gtt ggc ggt gtc cgg gcc atc cca tac atg cag gtc      871
 Gln Leu Arg Asn Val Gly Gly Val Arg Ala Ile Pro Tyr Met Gln Val
             265                 270                 275

 att cta atg ctc act aca gat ctg gat gga gaa gat gag aaa gac aag      919
 Ile Leu Met Leu Thr Thr Asp Leu Asp Gly Glu Asp Glu Lys Asp Lys
         280                 285                 290

 ggg gcc cta gac aac ctg ctc tcc cag ctt att gct gag ttg ggt atg      967
 Gly Ala Leu Asp Asn Leu Leu Ser Gln Leu Ile Ala Glu Leu Gly Met
     295                 300                 305

 gat aaa aag gat gtc tcc aag aag aat gag cgc agc gcc ctg aat gaa     1015
 Asp Lys Lys Asp Val Ser Lys Lys Asn Glu Arg Ser Ala Leu Asn Glu
 310                 315                 320                 325

 gtc cat ctg gta gta atg aga ctc ctg agt gtc ttc atg tcc cgc acc     1063
 Val His Leu Val Val Met Arg Leu Leu Ser Val Phe Met Ser Arg Thr
                 330                 335                 340

 aaa tct gga tcc aag tct tcc ata tgt gag tca tct tcc ctc atc tcc     1111
 Lys Ser Gly Ser Lys Ser Ser Ile Cys Glu Ser Ser Ser Leu Ile Ser
             345                 350                 355

 agt gcc aca gca gca gct cta ctg agc tct ggg gct gtg gac tac tgc     1159
 Ser Ala Thr Ala Ala Ala Leu Leu Ser Ser Gly Ala Val Asp Tyr Cys
         360                 365                 370

 ctg cac gtg ctc aaa tca ctg ctg gaa tat tgg aag agc caa cag aat     1207
 Leu His Val Leu Lys Ser Leu Leu Glu Tyr Trp Lys Ser Gln Gln Asn
     375                 380                 385

 gac gag gag cct gtg gct acc agc cag ttg ctg aaa cca cat act acc     1255
 Asp Glu Glu Pro Val Ala Thr Ser Gln Leu Leu Lys Pro His Thr Thr
 390                 395                 400                 405

 tcc tcc cca cct gac atg agc cca ttc ttt ctc cgc cag tat gtg aag     1303
 Ser Ser Pro Pro Asp Met Ser Pro Phe Phe Leu Arg Gln Tyr Val Lys
                 410                 415                 420

 ggt cat gct gct gat gtg ttt gag gcc tat act cag ctt cta aca gaa     1351
 Gly His Ala Ala Asp Val Phe Glu Ala Tyr Thr Gln Leu Leu Thr Glu
             425                 430                 435

 atg gta ctg agg ctt cct tac caa atc aaa aag att act gac acc aat     1399
 Met Val Leu Arg Leu Pro Tyr Gln Ile Lys Lys Ile Thr Asp Thr Asn
         440                 445                 450

 tct cga atc cca cct cct gtc ttt gac cac tcg tgg ttt tac ttt ctc     1447
 Ser Arg Ile Pro Pro Pro Val Phe Asp His Ser Trp Phe Tyr Phe Leu
     455                 460                 465

 tcc gag tac ctc atg atc cag cag act cca ttt gtg cgc cgt caa gtc     1495
 Ser Glu Tyr Leu Met Ile Gln Gln Thr Pro Phe Val Arg Arg Gln Val
 470                 475                 480                 485

 cgc aaa ctt ctg ctc ttc atc tgt gga tcc aaa gag aag tac cgc cag     1543
 Arg Lys Leu Leu Leu Phe Ile Cys Gly Ser Lys Glu Lys Tyr Arg Gln
                 490                 495                 500

 ctc cgg gat ttg cac acc ctg gac tct cac gtg cgt ggg atc aag aag     1591
 Leu Arg Asp Leu His Thr Leu Asp Ser His Val Arg Gly Ile Lys Lys
             505                 510                 515

 ctg cta gaa gag cag ggg ata ttc ctc cgg gca agt gtg gtt aca gcc     1639
 Leu Leu Glu Glu Gln Gly Ile Phe Leu Arg Ala Ser Val Val Thr Ala
         520                 525                 530

 agc tca ggc tcc gcc ttg caa tat gac aca ctc atc agc ctg atg gag     1687
 Ser Ser Gly Ser Ala Leu Gln Tyr Asp Thr Leu Ile Ser Leu Met Glu
     535                 540                 545

 cac ctg aaa gcc tgt gca gag att gcc gcc cag cga acc atc aac tgg     1735
 His Leu Lys Ala Cys Ala Glu Ile Ala Ala Gln Arg Thr Ile Asn Trp
 550                 555                 560                 565

 cag aaa ttc tgc atc aaa gat gac tcc gtc ctg tac ttc ctc ctc caa     1783
 Gln Lys Phe Cys Ile Lys Asp Asp Ser Val Leu Tyr Phe Leu Leu Gln
                 570                 575                 580

 gtc agt ttc ctt gtg gat gag ggc gtg tcc cca gtg ctg ctg caa ctg     1831
 Val Ser Phe Leu Val Asp Glu Gly Val Ser Pro Val Leu Leu Gln Leu
             585                 590                 595

 ctc tcc tgt gct ctg tgc ggc agc aag gtg ctc gct gca ctg gca gcc     1879
 Leu Ser Cys Ala Leu Cys Gly Ser Lys Val Leu Ala Ala Leu Ala Ala
         600                 605                 610

 tct tcg gga tcc tcc agt gct tct tcc tcc tca gcc cct gtg gct gcc     1927
 Ser Ser Gly Ser Ser Ser Ala Ser Ser Ser Ser Ala Pro Val Ala Ala
     615                 620                 625

 agt tct gga caa gcc aca aca cag tcc aag tct tcc act aaa aag agc     1975
 Ser Ser Gly Gln Ala Thr Thr Gln Ser Lys Ser Ser Thr Lys Lys Ser
 630                 635                 640                 645

 aag aaa gaa gaa aaa gaa aag gag aaa gat ggt gag acc tct ggc agc     2023
 Lys Lys Glu Glu Lys Glu Lys Glu Lys Asp Gly Glu Thr Ser Gly Ser
                 650                 655                 660

 cag gag gac cag ctg tgc aca gct ctg gtg aac cag ctg aac aaa ttt     2071
 Gln Glu Asp Gln Leu Cys Thr Ala Leu Val Asn Gln Leu Asn Lys Phe
             665                 670                 675

 gcc gat aag gaa acc ctg atc cag ttc ctg cgt tgt ttc ctg tta gag     2119
 Ala Asp Lys Glu Thr Leu Ile Gln Phe Leu Arg Cys Phe Leu Leu Glu
         680                 685                 690

 tcc aat tct tcc tcg gtg cgc tgg cag gcc cac tgt ctg aca ctg cac     2167
 Ser Asn Ser Ser Ser Val Arg Trp Gln Ala His Cys Leu Thr Leu His
     695                 700                 705

 atc tac aga aat tcc agc aaa tct caa cag gag ctc ctg cta gat ctg     2215
 Ile Tyr Arg Asn Ser Ser Lys Ser Gln Gln Glu Leu Leu Leu Asp Leu
 710                 715                 720                 725

 atg tgg tcc atc tgg cca gaa ctc cca gcc tat ggt cgt aag gct gcc     2263
 Met Trp Ser Ile Trp Pro Glu Leu Pro Ala Tyr Gly Arg Lys Ala Ala
                 730                 735                 740

 cag ttt gtg gac cta cta gga tat ttc tcc ctg aaa act cca caa aca     2311
 Gln Phe Val Asp Leu Leu Gly Tyr Phe Ser Leu Lys Thr Pro Gln Thr
             745                 750                 755

 gag aag aag ttg aag gag tat tca cag aag gct gtg gag att ctg cgg     2359
 Glu Lys Lys Leu Lys Glu Tyr Ser Gln Lys Ala Val Glu Ile Leu Arg
         760                 765                 770

 act caa aac cat att ctt acc aac cac ccc aac tcg aac att tat aac     2407
 Thr Gln Asn His Ile Leu Thr Asn His Pro Asn Ser Asn Ile Tyr Asn
     775                 780                 785

 act ttg tct ggc tta gtg gag ttt gat ggc tat tac ctg gag agc gat     2455
 Thr Leu Ser Gly Leu Val Glu Phe Asp Gly Tyr Tyr Leu Glu Ser Asp
 790                 795                 800                 805

 ccc tgc ctg gtg tgt aat aac ccg gaa gta ccg ttc tgt tat atc aag     2503
 Pro Cys Leu Val Cys Asn Asn Pro Glu Val Pro Phe Cys Tyr Ile Lys
                 810                 815                 820

 ctg tct tcc att aaa gtg gac acg cgg tac acc acc acc cag cag gtt     2551
 Leu Ser Ser Ile Lys Val Asp Thr Arg Tyr Thr Thr Thr Gln Gln Val
             825                 830                 835

 gtg aag ctc att ggc agt cac acc atc agc aaa gtg aca gtg aaa atc     2599
 Val Lys Leu Ile Gly Ser His Thr Ile Ser Lys Val Thr Val Lys Ile
         840                 845                 850

 ggg gat ctg aaa cgg acc aag atg gtg cgg acc atc aac ctg tat tat     2647
 Gly Asp Leu Lys Arg Thr Lys Met Val Arg Thr Ile Asn Leu Tyr Tyr
     855                 860                 865

 aac aac cga acc gtg cag gcc atc gtg gag ttg aaa aac aag cca gct     2695
 Asn Asn Arg Thr Val Gln Ala Ile Val Glu Leu Lys Asn Lys Pro Ala
 870                 875                 880                 885

 cgc tgg cac aaa gcc aag aag gtt cag ctg acc cct gga cag aca gag     2743
 Arg Trp His Lys Ala Lys Lys Val Gln Leu Thr Pro Gly Gln Thr Glu
                 890                 895                 900

 gtg aag att gac ctg ccg ttg ccc att gtg gcc tcc aat ctg atg att     2791
 Val Lys Ile Asp Leu Pro Leu Pro Ile Val Ala Ser Asn Leu Met Ile
             905                 910                 915

 gag ttt gca gac ttc tat gaa aac tac cag gcc tcc aca gag acc ctg     2839
 Glu Phe Ala Asp Phe Tyr Glu Asn Tyr Gln Ala Ser Thr Glu Thr Leu
         920                 925                 930

 cag tgc cct cgc tgt agt gcc tcg gtc cct gcc aac cca gga gtc tgt     2887
 Gln Cys Pro Arg Cys Ser Ala Ser Val Pro Ala Asn Pro Gly Val Cys
     935                 940                 945

 ggc aac tgt gga gag aat gtg tac cag tgt cac aaa tgc aga tcc atc     2935
 Gly Asn Cys Gly Glu Asn Val Tyr Gln Cys His Lys Cys Arg Ser Ile
 950                 955                 960                 965

 aac tac gat gaa aag gat ccc ttc ctc tgc aat gcc tgt ggc ttc tgt     2983
 Asn Tyr Asp Glu Lys Asp Pro Phe Leu Cys Asn Ala Cys Gly Phe Cys
                 970                 975                 980

 aaa tat gcc cgc ttc gac ttc atg ctc tat gcc aag cct tgc tgt gca     3031
 Lys Tyr Ala Arg Phe Asp Phe Met Leu Tyr Ala Lys Pro Cys Cys Ala
             985                 990                 995

 gtg gat ccc att gag aat gaa gaa gac cgg aag aag gct gta tcc aac     3079
 Val Asp Pro Ile Glu Asn Glu Glu Asp Arg Lys Lys Ala Val Ser Asn
        1000                1005                1010

 atc aat aca ctt ttg gac aaa gct gat cga gtg tat cat cag ctg atg     3127
 Ile Asn Thr Leu Leu Asp Lys Ala Asp Arg Val Tyr His Gln Leu Met
    1015                1020                1025

 gga cac cgg cca cag ctg gag aac ctg ctc tgc aaa gtg aat gag gca     3175
 Gly His Arg Pro Gln Leu Glu Asn Leu Leu Cys Lys Val Asn Glu Ala
1030                1035                1040                1045

 gct cca gaa aag cca cag gat gac tca gga aca gca ggg ggc atc agc     3223
 Ala Pro Glu Lys Pro Gln Asp Asp Ser Gly Thr Ala Gly Gly Ile Ser
                1050                1055                1060

 tcc act tct gcc agt gtg aat cgt tac atc ctg cag ttg gct cag gag     3271
 Ser Thr Ser Ala Ser Val Asn Arg Tyr Ile Leu Gln Leu Ala Gln Glu
            1065                1070                1075

 tat tgt gga gac tgc aag aac tct ttt gat gaa ctc tcc aaa atc atc     3319
 Tyr Cys Gly Asp Cys Lys Asn Ser Phe Asp Glu Leu Ser Lys Ile Ile
        1080                1085                1090

 cag aaa gtc ttt gct tcg cgc aaa gag ttg ttg gaa tat gac cta cag     3367
 Gln Lys Val Phe Ala Ser Arg Lys Glu Leu Leu Glu Tyr Asp Leu Gln
    1095                1100                1105

 cag agg gaa gca gcc act aaa tca tcc cgg acc tcc gtg cag ccc aca     3415
 Gln Arg Glu Ala Ala Thr Lys Ser Ser Arg Thr Ser Val Gln Pro Thr
1110                1115                1120                1125

 ttc act gcc agc cag tac cgt gcc tta tcc gtc ctg ggc tgt ggc cac     3463
 Phe Thr Ala Ser Gln Tyr Arg Ala Leu Ser Val Leu Gly Cys Gly His
                1130                1135                1140

 aca tcc tcc acc aag tgc tat ggc tgc gcc tcg gct gtc aca gaa cat     3511
 Thr Ser Ser Thr Lys Cys Tyr Gly Cys Ala Ser Ala Val Thr Glu His
            1145                1150                1155

 tgt atc aca cta ctt cgg gcc ctg gcc acc aac cca gcc ttg agg cac     3559
 Cys Ile Thr Leu Leu Arg Ala Leu Ala Thr Asn Pro Ala Leu Arg His
        1160                1165                1170

 atc ctt gtc tcc cag ggc ctt atc cgg gag ctc ttt gat tat aat ctt     3607
 Ile Leu Val Ser Gln Gly Leu Ile Arg Glu Leu Phe Asp Tyr Asn Leu
    1175                1180                1185

 cgc cga ggg gct gcg gcc atg cgg gag gag gtc cgc cag ctc atg tgc     3655
 Arg Arg Gly Ala Ala Ala Met Arg Glu Glu Val Arg Gln Leu Met Cys
1190                1195                1200                1205

 ctc cta act cga gac aac cca gaa gcc acc caa cag atg aat gac ctg     3703
 Leu Leu Thr Arg Asp Asn Pro Glu Ala Thr Gln Gln Met Asn Asp Leu
                1210                1215                1220

 att att ggc aag gtc tcc aca gcc ctg aag ggc cac tgg gcc aac ccc     3751
 Ile Ile Gly Lys Val Ser Thr Ala Leu Lys Gly His Trp Ala Asn Pro
            1225                1230                1235

 gat ctg gca agt agc ctg cag tat gaa atg ctg ctg ctg acg gat tct     3799
 Asp Leu Ala Ser Ser Leu Gln Tyr Glu Met Leu Leu Leu Thr Asp Ser
        1240                1245                1250

 atc tcc aag gag gac agc tgc tgg gag ctc cgg tta cgc tgt gct ctc     3847
 Ile Ser Lys Glu Asp Ser Cys Trp Glu Leu Arg Leu Arg Cys Ala Leu
    1255                1260                1265

 agc ctt ttc ctc atg gct gtg aac att aag act cct gtg gtg gtt gaa     3895
 Ser Leu Phe Leu Met Ala Val Asn Ile Lys Thr Pro Val Val Val Glu
1270                1275                1280                1285

 aac att acc ctc atg tgc ctg agg atc ttg cag aag ctg ata aaa cca     3943
 Asn Ile Thr Leu Met Cys Leu Arg Ile Leu Gln Lys Leu Ile Lys Pro
                1290                1295                1300

 cct gct ccc act agc aag aag aac aag gat gtc ccc gtt gag gcc ctc     3991
 Pro Ala Pro Thr Ser Lys Lys Asn Lys Asp Val Pro Val Glu Ala Leu
            1305                1310                1315

 acc acg gtg aag cca tac tgc aat gag atc cat gcc cag gct caa ctg     4039
 Thr Thr Val Lys Pro Tyr Cys Asn Glu Ile His Ala Gln Ala Gln Leu
        1320                1325                1330

 tgg ctc aag aga gac ccc aag gca tcc tat gat gcc tgg aag aag tgt     4087
 Trp Leu Lys Arg Asp Pro Lys Ala Ser Tyr Asp Ala Trp Lys Lys Cys
    1335                1340                1345

 ctt cct atc aga ggg ata gat ggc aat ggg aaa gcc ccc agc aaa tca     4135
 Leu Pro Ile Arg Gly Ile Asp Gly Asn Gly Lys Ala Pro Ser Lys Ser
1350                1355                1360                1365

 gag ctc cgc cat ctc tat ttg act gag aag tat gtg tgg agg tgg aaa     4183
 Glu Leu Arg His Leu Tyr Leu Thr Glu Lys Tyr Val Trp Arg Trp Lys
                1370                1375                1380

 cag ttc ctg agt cgt cgg ggg aag agg acc tcc ccc ttg gat ctc aaa     4231
 Gln Phe Leu Ser Arg Arg Gly Lys Arg Thr Ser Pro Leu Asp Leu Lys
            1385                1390                1395

 ctg ggg cat aac aac tgg ctg cga caa gtg ctt ttc act cca gca acg     4279
 Leu Gly His Asn Asn Trp Leu Arg Gln Val Leu Phe Thr Pro Ala Thr
        1400                1405                1410

 cag gcc gca cgg cag gca gcc tgt acc att gtg gaa gct cta gcc acc     4327
 Gln Ala Ala Arg Gln Ala Ala Cys Thr Ile Val Glu Ala Leu Ala Thr
    1415                1420                1425

 att ccc agc cgc aag cag cag gtc ctg gac ctg ctt acc agt tac ctg     4375
 Ile Pro Ser Arg Lys Gln Gln Val Leu Asp Leu Leu Thr Ser Tyr Leu
1430                1435                1440                1445

 gat gag ctg agc ata gct ggg gag tgt gca gct gag tac ctg gct ctc     4423
 Asp Glu Leu Ser Ile Ala Gly Glu Cys Ala Ala Glu Tyr Leu Ala Leu
                1450                1455                1460

 tac cag aag ctc atc act tct gcg cac tgg aaa gtc tac ttg gca gct     4471
 Tyr Gln Lys Leu Ile Thr Ser Ala His Trp Lys Val Tyr Leu Ala Ala
            1465                1470                1475

 cgg gga gtc cta ccc tat gtg ggc aac ctc atc acc aag gaa ata gct     4519
 Arg Gly Val Leu Pro Tyr Val Gly Asn Leu Ile Thr Lys Glu Ile Ala
        1480                1485                1490

 cgt ctg ctg gcc ctg gag gag gct acc ctg agt acc gat ctg cag cag     4567
 Arg Leu Leu Ala Leu Glu Glu Ala Thr Leu Ser Thr Asp Leu Gln Gln
    1495                1500                1505

 ggt tat gcc ctt aaa agt ctc aca ggc ctt ctc tcc tcc ttt gtt gag     4615
 Gly Tyr Ala Leu Lys Ser Leu Thr Gly Leu Leu Ser Ser Phe Val Glu
1510                1515                1520                1525

 gtg gaa tcc atc aaa aga cat ttt aaa agt cgc ttg gtg ggt act gtg     4663
 Val Glu Ser Ile Lys Arg His Phe Lys Ser Arg Leu Val Gly Thr Val
                1530                1535                1540

 ctg aat gga tac ctg tgc ttg cgg aag ctg gtg gtg cag agg acc aag     4711
 Leu Asn Gly Tyr Leu Cys Leu Arg Lys Leu Val Val Gln Arg Thr Lys
            1545                1550                1555

 ctg atc gat gag acg cag gac atg ctg ctg gag atg ctg gag gac atg     4759
 Leu Ile Asp Glu Thr Gln Asp Met Leu Leu Glu Met Leu Glu Asp Met
        1560                1565                1570

 acc aca ggt aca gaa tca gaa acc aag gcc ttc atg gct gtg tgc att     4807
 Thr Thr Gly Thr Glu Ser Glu Thr Lys Ala Phe Met Ala Val Cys Ile
    1575                1580                1585

 gag aca gcc aag cgc tac aat ctg gat gac tac cgg acc ccg gtg ttc     4855
 Glu Thr Ala Lys Arg Tyr Asn Leu Asp Asp Tyr Arg Thr Pro Val Phe
1590                1595                1600                1605

 atc ttc gag agg ctc tgc agc atc att tat cct gag gag aat gaa gtc     4903
 Ile Phe Glu Arg Leu Cys Ser Ile Ile Tyr Pro Glu Glu Asn Glu Val
                1610                1615                1620

 act gag ttc ttt gtg acc ctg gag aag gat ccc caa caa gaa gac ttc     4951
 Thr Glu Phe Phe Val Thr Leu Glu Lys Asp Pro Gln Gln Glu Asp Phe
            1625                1630                1635

 tta cag ggc agg atg cct ggg aac ccg tat agc agc aat gag cca ggc     4999
 Leu Gln Gly Arg Met Pro Gly Asn Pro Tyr Ser Ser Asn Glu Pro Gly
        1640                1645                1650

 atc ggg ccg ctg atg agg gat ata aag aac aag att tgc cag gac tgt     5047
 Ile Gly Pro Leu Met Arg Asp Ile Lys Asn Lys Ile Cys Gln Asp Cys
    1655                1660                1665

 gac tta gtg gcc ctc ctg gaa gat gac agt ggc atg gag ctt cta gtg     5095
 Asp Leu Val Ala Leu Leu Glu Asp Asp Ser Gly Met Glu Leu Leu Val
1670                1675                1680                1685

 aac aat aaa atc att agt ttg gac ctt cct gtg gct gaa gtt tac aag     5143
 Asn Asn Lys Ile Ile Ser Leu Asp Leu Pro Val Ala Glu Val Tyr Lys
                1690                1695                1700

 aaa gtc tgg tgt acc acg aat gag gga gag ccc atg agg att gtt tat     5191
 Lys Val Trp Cys Thr Thr Asn Glu Gly Glu Pro Met Arg Ile Val Tyr
            1705                1710                1715

 cgt atg cgg ggg ctg ctg ggc gat gcc aca gag gag ttc att gag tcc     5239
 Arg Met Arg Gly Leu Leu Gly Asp Ala Thr Glu Glu Phe Ile Glu Ser
        1720                1725                1730

 ctg gac tct act aca gat gaa gaa gaa gat gaa gaa gaa gtg tat aaa     5287
 Leu Asp Ser Thr Thr Asp Glu Glu Glu Asp Glu Glu Glu Val Tyr Lys
    1735                1740                1745

 atg gct ggt gtg atg gcc cag tgt ggg ggc ctg gaa tgc atg ctt aac     5335
 Met Ala Gly Val Met Ala Gln Cys Gly Gly Leu Glu Cys Met Leu Asn
1750                1755                1760                1765

 aga ctc gca ggg atc aga gat ttc aag cag gga cgc cac ctt cta aca     5383
 Arg Leu Ala Gly Ile Arg Asp Phe Lys Gln Gly Arg His Leu Leu Thr
                1770                1775                1780

 gtg cta ctg aaa ttg ttc agt tac tgc gtg aag gtg aaa gtc aac cgg     5431
 Val Leu Leu Lys Leu Phe Ser Tyr Cys Val Lys Val Lys Val Asn Arg
            1785                1790                1795

 cag caa ctg gtc aaa ctg gaa atg aac acc ttg aac gtc atg ctg ggg     5479
 Gln Gln Leu Val Lys Leu Glu Met Asn Thr Leu Asn Val Met Leu Gly
        1800                1805                1810

 acc cta aac ctg gcc ctt gta gct gaa caa gaa agc aag gac agt ggg     5527
 Thr Leu Asn Leu Ala Leu Val Ala Glu Gln Glu Ser Lys Asp Ser Gly
    1815                1820                1825

 ggt gca gct gtg gct gag cag gtg ctt agc atc atg gag atc att cta     5575
 Gly Ala Ala Val Ala Glu Gln Val Leu Ser Ile Met Glu Ile Ile Leu
1830                1835                1840                1845

 gat gag tcc aat gct gag ccc ctg agt gag gac aag ggc aac ctc ctc     5623
 Asp Glu Ser Asn Ala Glu Pro Leu Ser Glu Asp Lys Gly Asn Leu Leu
                1850                1855                1860

 ctg aca ggt gac aag gat caa ctg gtg atg ctc ttg gac cag atc aac     5671
 Leu Thr Gly Asp Lys Asp Gln Leu Val Met Leu Leu Asp Gln Ile Asn
            1865                1870                1875

 agc acc ttt gtt cgc tcc aac ccc agt gtg ctc cag ggc ctg ctt cgc     5719
 Ser Thr Phe Val Arg Ser Asn Pro Ser Val Leu Gln Gly Leu Leu Arg
        1880                1885                1890

 atc atc ccg tac ctt tcc ttt gga gag gtg gag aaa atg cag atc ttg     5767
 Ile Ile Pro Tyr Leu Ser Phe Gly Glu Val Glu Lys Met Gln Ile Leu
    1895                1900                1905

 gtg gag cga ttc aaa cca tac tgc aac ttt gat aaa tat gat gaa gat     5815
 Val Glu Arg Phe Lys Pro Tyr Cys Asn Phe Asp Lys Tyr Asp Glu Asp
1910                1915                1920                1925

 cac agt ggt gat gat aaa gtc ttc ctg gac tgc ttc tgt aaa ata gct     5863
 His Ser Gly Asp Asp Lys Val Phe Leu Asp Cys Phe Cys Lys Ile Ala
                1930                1935                1940

 gct ggc atc aag aac aac agc aat ggg cac cag ctg aag gat ctg att     5911
 Ala Gly Ile Lys Asn Asn Ser Asn Gly His Gln Leu Lys Asp Leu Ile
            1945                1950                1955

 ctc cag aag ggg atc acc cag aat gca ctt gac tac atg aaa aag cac     5959
 Leu Gln Lys Gly Ile Thr Gln Asn Ala Leu Asp Tyr Met Lys Lys His
        1960                1965                1970

 atc cct agc gcc aag aat ttg gat gcc gac atc tgg aaa aag ttt ttg     6007
 Ile Pro Ser Ala Lys Asn Leu Asp Ala Asp Ile Trp Lys Lys Phe Leu
    1975                1980                1985

 tct cgc cca gcc ttg cca ttt atc cta agg ctg ctt cgg ggc ctg gcc     6055
 Ser Arg Pro Ala Leu Pro Phe Ile Leu Arg Leu Leu Arg Gly Leu Ala
1990                1995                2000                2005

 atc cag cac cct ggc acc cag gtt ctg att gga act gat tcc atc ccg     6103
 Ile Gln His Pro Gly Thr Gln Val Leu Ile Gly Thr Asp Ser Ile Pro
                2010                2015                2020

 aac ctg cat aag ctg gag cag gtg tcc agt gat gag ggc att ggg acc     6151
 Asn Leu His Lys Leu Glu Gln Val Ser Ser Asp Glu Gly Ile Gly Thr
            2025                2030                2035

 ttg gca gag aac ctg ctg gaa gcc ctg cgg gaa cac cct gac gta aac     6199
 Leu Ala Glu Asn Leu Leu Glu Ala Leu Arg Glu His Pro Asp Val Asn
        2040                2045                2050

 aag aag att gac gca gcc cgc agg gag acc cgg gca gag aag aaa cgc     6247
 Lys Lys Ile Asp Ala Ala Arg Arg Glu Thr Arg Ala Glu Lys Lys Arg
    2055                2060                2065

 atg gcc atg gca atg agg cag aag gcc ctg ggc acc ctg ggc atg acg     6295
 Met Ala Met Ala Met Arg Gln Lys Ala Leu Gly Thr Leu Gly Met Thr
2070                2075                2080                2085

 aca aat gaa aag ggc cag gtc gtg acc aag aca gca ctc ctg aag cag     6343
 Thr Asn Glu Lys Gly Gln Val Val Thr Lys Thr Ala Leu Leu Lys Gln
                2090                2095                2100

 atg gaa gag ctg atc gag gag cct ggc ctc acg tgc tgc atc tgc agg     6391
 Met Glu Glu Leu Ile Glu Glu Pro Gly Leu Thr Cys Cys Ile Cys Arg
            2105                2110                2115

 gag gga tac aag ttc cag ccc aca aag gtc ctg ggc att tat acc ttc     6439
 Glu Gly Tyr Lys Phe Gln Pro Thr Lys Val Leu Gly Ile Tyr Thr Phe
        2120                2125                2130

 acg aag cgg gta gcc ttg gag gag atg gag aat aag ccc cgg aaa cag     6487
 Thr Lys Arg Val Ala Leu Glu Glu Met Glu Asn Lys Pro Arg Lys Gln
    2135                2140                2145

 cag ggc tac agc acc gtg tcc cac ttc aac att gtg cac tac gac tgc     6535
 Gln Gly Tyr Ser Thr Val Ser His Phe Asn Ile Val His Tyr Asp Cys
2150                2155                2160                2165

 cat ctg gct gcc gtc agg ttg gct cga ggc cgg gaa gag tgg gag agt     6583
 His Leu Ala Ala Val Arg Leu Ala Arg Gly Arg Glu Glu Trp Glu Ser
                2170                2175                2180

 gcc gcc ctg cag aat gcc aac acc aag tgc aac ggg ctc ctt ccg gtc     6631
 Ala Ala Leu Gln Asn Ala Asn Thr Lys Cys Asn Gly Leu Leu Pro Val
            2185                2190                2195

 tgg gga cct cat gtc cct gaa tca gct ttt gcc act tgc ttg gca aga     6679
 Trp Gly Pro His Val Pro Glu Ser Ala Phe Ala Thr Cys Leu Ala Arg
        2200                2205                2210

 cac aac act tac ctc cag gaa tgt aca ggc cag cgg gag ccc acg tat     6727
 His Asn Thr Tyr Leu Gln Glu Cys Thr Gly Gln Arg Glu Pro Thr Tyr
    2215                2220                2225

 cag ctc aac atc cat gac atc aaa ctg ctc ttc ctg cgc ttc gcc atg     6775
 Gln Leu Asn Ile His Asp Ile Lys Leu Leu Phe Leu Arg Phe Ala Met
2230                2235                2240                2245

 gag cag tcg ttc agc gca gac act ggc ggg ggc ggc cgg gag agc aac     6823
 Glu Gln Ser Phe Ser Ala Asp Thr Gly Gly Gly Gly Arg Glu Ser Asn
                2250                2255                2260

 atc cac ctg atc ccg tac atc att cac act gtg ctt tac gtc ctg aac     6871
 Ile His Leu Ile Pro Tyr Ile Ile His Thr Val Leu Tyr Val Leu Asn
            2265                2270                2275

 aca acc cga gca act tcc cga gaa gag aag aac ctc caa ggc ttt ctg     6919
 Thr Thr Arg Ala Thr Ser Arg Glu Glu Lys Asn Leu Gln Gly Phe Leu
        2280                2285                2290

 gaa cag ccc aag gag aag tgg gtg gag agt gcc ttt gaa gtg gac ggg     6967
 Glu Gln Pro Lys Glu Lys Trp Val Glu Ser Ala Phe Glu Val Asp Gly
    2295                2300                2305

 ccc tac tat ttc aca gtc ttg gcc ctt cac atc ctg ccc cct gag cag     7015
 Pro Tyr Tyr Phe Thr Val Leu Ala Leu His Ile Leu Pro Pro Glu Gln
2310                2315                2320                2325

 tgg aga gcc aca cgt gtg gaa atc ttg cgg agg ctg ttg gtg acc tcg     7063
 Trp Arg Ala Thr Arg Val Glu Ile Leu Arg Arg Leu Leu Val Thr Ser
                2330                2335                2340

 cag gct cgg gca gtg gct cca ggt gga gcc acc agg ctg aca gat aag     7111
 Gln Ala Arg Ala Val Ala Pro Gly Gly Ala Thr Arg Leu Thr Asp Lys
            2345                2350                2355

 gca gtg aag gac tat tcc gct tac cgt tct tcc ctt ctc ttt tgg gcc     7159
 Ala Val Lys Asp Tyr Ser Ala Tyr Arg Ser Ser Leu Leu Phe Trp Ala
        2360                2365                2370

 ctc gtc gat ctc att tac aac atg ttt aag aag gtg cct acc agt aac     7207
 Leu Val Asp Leu Ile Tyr Asn Met Phe Lys Lys Val Pro Thr Ser Asn
    2375                2380                2385

 aca gag gga ggc tgg tcc tgc tct ctc gct gag tac atc cgc cac aac     7255
 Thr Glu Gly Gly Trp Ser Cys Ser Leu Ala Glu Tyr Ile Arg His Asn
2390                2395                2400                2405

 gac atg ccc atc tac gaa gct gcc gac aaa gcc ctg aaa acc ttc cag     7303
 Asp Met Pro Ile Tyr Glu Ala Ala Asp Lys Ala Leu Lys Thr Phe Gln
                2410                2415                2420

 gag gag ttc atg cca gtg gag acc ttc tca gag ttc ctc gat gtg gcc     7351
 Glu Glu Phe Met Pro Val Glu Thr Phe Ser Glu Phe Leu Asp Val Ala
            2425                2430                2435

 ggt ctt tta tca gaa atc acc gat cca gag agc ttc ctg aag gac ctg     7399
 Gly Leu Leu Ser Glu Ile Thr Asp Pro Glu Ser Phe Leu Lys Asp Leu
        2440                2445                2450

 ttg aac tca gtc ccc tgaccaccac acagcagctg cggcggcgaa gacgaagctg     7454
 Leu Asn Ser Val Pro 
    2455

 gcttgccttc caccctctgt tctccctcct tgtgcattaa gttccctccg cgggatgctg   7514

 cattgttacc ccgccctccc ctctctcatt tttcttggtg tggcttgggg tttttaggct   7574

 tcctgtttta tctcgtgtgt gtggtgcacc agctatgagg ttgtctgtaa cccaagccat   7634

 caaagggcct gtacatacct aggagccatg agttgtcccg gccagcttca tacttgagtg   7694

 tgcacatctt gagaaataaa caagtgactt aacacacatt gaaaaaaaaa aaa          7747




      <210> 70
      <211> 1707
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1437)

      <400> 70
  atg aaa gtg agg tcg gcc ggc ggc gat gga gat gcc ttg tgc gtt aca      48
  Met Lys Val Arg Ser Ala Gly Gly Asp Gly Asp Ala Leu Cys Val Thr
    1               5                  10                  15

 gaa gag gac ctg gcg ggt gac gac gag gac atg ccg acc ttc cca tgc       96
 Glu Glu Asp Leu Ala Gly Asp Asp Glu Asp Met Pro Thr Phe Pro Cys
              20                  25                  30

 acc cag aag ggc cgg cca ggg ccc cgc tgc agc cgc tgc cag aag aac      144
 Thr Gln Lys Gly Arg Pro Gly Pro Arg Cys Ser Arg Cys Gln Lys Asn
          35                  40                  45

 cta tct ttg cac aca tcg gtg cgg att ctt tac ctc ttc ctg gcc ctg      192
 Leu Ser Leu His Thr Ser Val Arg Ile Leu Tyr Leu Phe Leu Ala Leu
      50                  55                  60

 ctc ctg gtg gcc gtg gct gtg ttg gcc tct ctg gtt ttc aga aaa gtg      240
 Leu Leu Val Ala Val Ala Val Leu Ala Ser Leu Val Phe Arg Lys Val
  65                  70                  75                  80

 gac tct ctc tcc gaa gac atc tcc ttg acc cag tct att tat gac aag      288
 Asp Ser Leu Ser Glu Asp Ile Ser Leu Thr Gln Ser Ile Tyr Asp Lys
                  85                  90                  95

 aag ctt gtg tta atg cag aaa aat ctc cag ggc ctg gat ccg aaa gcc      336
 Lys Leu Val Leu Met Gln Lys Asn Leu Gln Gly Leu Asp Pro Lys Ala
             100                 105                 110

 ctg aac aac tgc tct ttc tgc cat gaa gct ggg cag ctg ggg cca gag      384
 Leu Asn Asn Cys Ser Phe Cys His Glu Ala Gly Gln Leu Gly Pro Glu
         115                 120                 125

 atc cga aaa ctg cag gag gag ctg gag gga att cag aag ctg ctt ctg      432
 Ile Arg Lys Leu Gln Glu Glu Leu Glu Gly Ile Gln Lys Leu Leu Leu
     130                 135                 140

 gcc cag gag gtg cag ctg gac cag acc tta cag gcc cag gag gtg ctc      480
 Ala Gln Glu Val Gln Leu Asp Gln Thr Leu Gln Ala Gln Glu Val Leu
 145                 150                 155                 160

 tcc acc acc agc aga caa atc tcc cag gag atg ggc agt tgc tcc ttc      528
 Ser Thr Thr Ser Arg Gln Ile Ser Gln Glu Met Gly Ser Cys Ser Phe
                 165                 170                 175

 tcc atc cac cag gtt aac cag tct ctg ggg ctc ttc ctg gcc cag gtg      576
 Ser Ile His Gln Val Asn Gln Ser Leu Gly Leu Phe Leu Ala Gln Val
             180                 185                 190

 aga ggc tgg cag gcc acc aca gct ggc ctg gac ctc tct ctg aag gac      624
 Arg Gly Trp Gln Ala Thr Thr Ala Gly Leu Asp Leu Ser Leu Lys Asp
         195                 200                 205

 ctc acc cag gag tgc tac gat gtc aag gct gca gtg cac cag atc aac      672
 Leu Thr Gln Glu Cys Tyr Asp Val Lys Ala Ala Val His Gln Ile Asn
     210                 215                 220

 ttc acc gtg ggg cag act tcc gag tgg atc cac ggg atc cag cgg aag      720
 Phe Thr Val Gly Gln Thr Ser Glu Trp Ile His Gly Ile Gln Arg Lys
 225                 230                 235                 240

 aca gac gag gag acc ctg acc ctc cag aag att gtc acc gac tgg cag      768
 Thr Asp Glu Glu Thr Leu Thr Leu Gln Lys Ile Val Thr Asp Trp Gln
                 245                 250                 255

 aac tac aca cgg ctc ttc agc ggc ctg cgc acc acc tcc acc aag act      816
 Asn Tyr Thr Arg Leu Phe Ser Gly Leu Arg Thr Thr Ser Thr Lys Thr
             260                 265                 270

 gga gag gcg gtc aag aac atc cag gcc acc ctg ggg gcc tcc tca cag      864
 Gly Glu Ala Val Lys Asn Ile Gln Ala Thr Leu Gly Ala Ser Ser Gln
         275                 280                 285

 cgc atc agc cag aac tca gag agc atg cac gac ctg gta ctc cag gtc      912
 Arg Ile Ser Gln Asn Ser Glu Ser Met His Asp Leu Val Leu Gln Val
     290                 295                 300

 atg ggc ttg cag ctg cag ctg gat aac atc tcg tcc ttc ctg gat gac      960
 Met Gly Leu Gln Leu Gln Leu Asp Asn Ile Ser Ser Phe Leu Asp Asp
 305                 310                 315                 320

 cac gaa gag aac atg cat gat ctt cag tac cat acc cac tac gcc cag     1008
 His Glu Glu Asn Met His Asp Leu Gln Tyr His Thr His Tyr Ala Gln
                 325                 330                 335

 aac cgc act gtg gag agg ttt gag tct ctg gaa gga cgc atg gct tct     1056
 Asn Arg Thr Val Glu Arg Phe Glu Ser Leu Glu Gly Arg Met Ala Ser
             340                 345                 350

 cac gag att gaa att ggc acc atc ttc acc aac atc aat gcc acc gac     1104
 His Glu Ile Glu Ile Gly Thr Ile Phe Thr Asn Ile Asn Ala Thr Asp
         355                 360                 365

 aac cac gtg cac agc atg ctc aag tac ctg gat gac gtg cgg ctc tcc     1152
 Asn His Val His Ser Met Leu Lys Tyr Leu Asp Asp Val Arg Leu Ser
     370                 375                 380

 tgc acg ctg ggc ttc cac acc cat gcc gag gag ctc tac tac ctg aac     1200
 Cys Thr Leu Gly Phe His Thr His Ala Glu Glu Leu Tyr Tyr Leu Asn
 385                 390                 395                 400

 aag tct gtc tcc atc atg ctg ggc acc aca gac ctg ctc cgg gag cgc     1248
 Lys Ser Val Ser Ile Met Leu Gly Thr Thr Asp Leu Leu Arg Glu Arg
                 405                 410                 415

 ttc agc ctg ctc agt gcc cgg ctg gac ctc aac gtc cgg aac ctc tcc     1296
 Phe Ser Leu Leu Ser Ala Arg Leu Asp Leu Asn Val Arg Asn Leu Ser
             420                 425                 430

 atg atc gtg gag gag atg aag gca gtg gac aca cag cat gga gaa atc     1344
 Met Ile Val Glu Glu Met Lys Ala Val Asp Thr Gln His Gly Glu Ile
         435                 440                 445

 ctt cgc aat gtc acc atc cta cga gga aac aga aac ttg gat ctg caa     1392
 Leu Arg Asn Val Thr Ile Leu Arg Gly Asn Arg Asn Leu Asp Leu Gln
     450                 455                 460

 gaa gga gtg gag agc agc aga agt ggt aaa tta gaa cgt aaa tat taa     1440
 Glu Gly Val Glu Ser Ser Arg Ser Gly Lys Leu Glu Arg Lys Tyr 
 465                 470                 475

 aatgcatgga tttttttctc tctgaattct cttgagagac aactgactat tgtaagggaa   1500

 gattatttta agactatttt aagataagac tggagattgg atttataatg tgtcaagttg   1560

 atatgacaac aagagcacca gggatagcta attgcaaatt taatggtgga agtctaaatg   1620

 ttttccctta taaaccagaa ataaggcaag gatctcatct cccaacactt ttattctatt   1680

 tgactagagg tcctccccaa cattgta                                       1707




      <210> 71
      <211> 1835
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (212)..(1549)

      <400> 71
 cgtggagttt ctctgagaca aacacaggaa taccccgaga taatgtgagc agtatctcca     60

 aagtccaggc tgagtcatat ggtaggtgct gtttggaata tctagcctgc ctgccttgca    120

 gattcaaatg cctcgggcag gagggtgagc tagctgccga tcctgctctg ctcctgggtt    180

 tgctgtgtgg cccttggtag aacgtcatga c   atg aat acc tta agc ctg ccc     232
                                      Met Asn Thr Leu Ser Leu Pro
                                        1               5

 ctg aac ata cgc cga ggg ggg tca gac acc aac ctc aac ttt gat gtc      280
 Leu Asn Ile Arg Arg Gly Gly Ser Asp Thr Asn Leu Asn Phe Asp Val
          10                  15                  20

 ccg gat ggc atc ctg gac ttc cac aag gtc aaa ctc act gca gac agc      328
 Pro Asp Gly Ile Leu Asp Phe His Lys Val Lys Leu Thr Ala Asp Ser
      25                  30                  35

 ctg aag caa aaa att cta aag gta aca gag cag ata aaa att gag caa      376
 Leu Lys Gln Lys Ile Leu Lys Val Thr Glu Gln Ile Lys Ile Glu Gln
  40                  45                  50                  55

 aca tcg cgc gat ggg aat gtt gcg gag tat ctg aaa cta gtg aac aac      424
 Thr Ser Arg Asp Gly Asn Val Ala Glu Tyr Leu Lys Leu Val Asn Asn
                  60                  65                  70

 gca gac aag cag cag gcg gga cgt atc aag caa gtc ttt gag aag aag      472
 Ala Asp Lys Gln Gln Ala Gly Arg Ile Lys Gln Val Phe Glu Lys Lys
              75                  80                  85

 aat cag agg gca gct cac tcc atc gcc cag ctg cag aag aag tta gag      520
 Asn Gln Arg Ala Ala His Ser Ile Ala Gln Leu Gln Lys Lys Leu Glu
          90                  95                 100

 cag tat cat cga aag ctc aga gag atc gag cag aat gga gcc tct agg      568
 Gln Tyr His Arg Lys Leu Arg Glu Ile Glu Gln Asn Gly Ala Ser Arg
     105                 110                 115

 agc tca aag gac att tcc aaa gac cac ctg aag gat ata cat cgc tct      616
 Ser Ser Lys Asp Ile Ser Lys Asp His Leu Lys Asp Ile His Arg Ser
 120                 125                 130                 135

 ttg aaa gat gcc cac gtg aaa tct cga act gcc ccc cat tgc atg gag      664
 Leu Lys Asp Ala His Val Lys Ser Arg Thr Ala Pro His Cys Met Glu
                 140                 145                 150

 agc agc aaa tcg ggc atg cca ggg gtc tca ctt act cca cct gtg ttc      712
 Ser Ser Lys Ser Gly Met Pro Gly Val Ser Leu Thr Pro Pro Val Phe
             155                 160                 165

 gtt ttc aat aag tcc aga gag ttt gcc aac ctg atc cgg aat aag ttt      760
 Val Phe Asn Lys Ser Arg Glu Phe Ala Asn Leu Ile Arg Asn Lys Phe
         170                 175                 180

 ggc agc gcc gac aac att gct cac ttg aaa aat tcc tta gag gag ttt      808
 Gly Ser Ala Asp Asn Ile Ala His Leu Lys Asn Ser Leu Glu Glu Phe
     185                 190                 195

 agg cca gag gcg agt gcc agg gcc tac ggg ggc agc gct acc atc gtg      856
 Arg Pro Glu Ala Ser Ala Arg Ala Tyr Gly Gly Ser Ala Thr Ile Val
 200                 205                 210                 215

 aac aaa ccc aag tat ggc agt gat gat gaa tgt tcg agt ggc acg tca      904
 Asn Lys Pro Lys Tyr Gly Ser Asp Asp Glu Cys Ser Ser Gly Thr Ser
                 220                 225                 230

 ggc tcg gcc gac agt aac gga aac cag tcg ttt ggg gct ggt gga gcc      952
 Gly Ser Ala Asp Ser Asn Gly Asn Gln Ser Phe Gly Ala Gly Gly Ala
             235                 240                 245

 agc aca ctg gac agc cag ggc aag ctc gcc gtg atc ctg gag gaa ctg     1000
 Ser Thr Leu Asp Ser Gln Gly Lys Leu Ala Val Ile Leu Glu Glu Leu
         250                 255                 260

 agg gag atc aag gat acc caa gct cag ctg gct gag gac atc gag gca     1048
 Arg Glu Ile Lys Asp Thr Gln Ala Gln Leu Ala Glu Asp Ile Glu Ala
     265                 270                 275

 ctg aag gtg cag ttt aag aga gaa tat ggt ttt att tct cag acc ctg     1096
 Leu Lys Val Gln Phe Lys Arg Glu Tyr Gly Phe Ile Ser Gln Thr Leu
 280                 285                 290                 295

 caa gag gaa aga tac agg tat gag cga ctg gag gac cag ctg cat gac     1144
 Gln Glu Glu Arg Tyr Arg Tyr Glu Arg Leu Glu Asp Gln Leu His Asp
                 300                 305                 310

 ctg acg gac ctg cat cag cat gag aca gcc aac ctg aag cag gag ctg     1192
 Leu Thr Asp Leu His Gln His Glu Thr Ala Asn Leu Lys Gln Glu Leu
             315                 320                 325

 gcc agc att gag gag aag gtg gcc tac cag gcc tac gag cgc tcg cgg     1240
 Ala Ser Ile Glu Glu Lys Val Ala Tyr Gln Ala Tyr Glu Arg Ser Arg
         330                 335                 340

 gac atc cag gaa gcc ttg gaa tcc tgc cag act cgc att tct aag ctg     1288
 Asp Ile Gln Glu Ala Leu Glu Ser Cys Gln Thr Arg Ile Ser Lys Leu
     345                 350                 355

 gag ctc cac cag caa gag cag caa gct ctg cag aca gac acc gtg aat     1336
 Glu Leu His Gln Gln Glu Gln Gln Ala Leu Gln Thr Asp Thr Val Asn
 360                 365                 370                 375

 gct aaa gtt ctc ctg ggg agg tgc atc aac gtg atc ctg gcc ttc atg     1384
 Ala Lys Val Leu Leu Gly Arg Cys Ile Asn Val Ile Leu Ala Phe Met
                 380                 385                 390

 act gtc atc tta gtg tgt gtg tcc acc atc gcg aag ttc gtc tca ccc     1432
 Thr Val Ile Leu Val Cys Val Ser Thr Ile Ala Lys Phe Val Ser Pro
             395                 400                 405

 atg atg aag agt cgc tgc cac att ctt ggc acc ttc ttt gcc gtg act     1480
 Met Met Lys Ser Arg Cys His Ile Leu Gly Thr Phe Phe Ala Val Thr
         410                 415                 420

 ctt ctt gct ata ttt tgt aaa aac tgg gac cat atc ctg tgt gcc ata     1528
 Leu Leu Ala Ile Phe Cys Lys Asn Trp Asp His Ile Leu Cys Ala Ile
     425                 430                 435

 gaa agg atg ata ata cca aga tg aagccactgg ttcctgcctt caagttcttt     1581
 Glu Arg Met Ile Ile Pro Arg 
 440                 445

 caagttttta ttttaaagaa aactctgtgc atactaccaa attttacagt gaatgattgt   1641

 gcggactcgt gtgtaagaaa aactaggact gtgtggtgta aataactaca attctcttaa   1701

 ctcggtagca gttgccaact cagtccttgt acttcgttaa cacggatctg tttcagagct   1761

 ctcctacctt gctcactgcc ttaatcagac cgatttcctg cccacctgac cagcccaacg   1821

 tggtaaacct ctgt                                                     1835




      <210> 72
      <211> 5824
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (590)..(5821)

      <400> 72
 ttcgagatcc ctagtcagtg tggtggaatt cctttacacc agacaggcct cattttaaat     60

 cctgtctcta ccgtttacta gctgtgtgat cttgggcaag atacttaacc tctctgagtt    120

 tctgtttcct catctatcaa tgaagatgat actatgaacc caataaggct gttaaaacag    180

 gttttttatt acctaccacg gcgggctgta catctctgac gtacagaagg aggacgccct    240

 ctccacctat cgctgcatca ccaagcacaa gtatagcggg gagacccggc agagcaatgg    300

 ggcacgcctc tctgtgacag accctgctga gtcgatcccc accatcctgg atggcttcca    360

 ctcccaggaa gtgtgggccg gccacaccgt ggagctgccc tgcaccgcct cgggctaccc    420

 tatccccgcc atccgctggc tcaaggatgg ccggcccctc ccggctgaca gccgctggac    480

 caagcgcatc acagggctga ccatcagcga cttgcggacc gaggacagcg gcacctacat    540

 ttgtgaggtc accaacacct tcggttcggc agaggccaca ggcatcctc    atg gtc     595
                                                          Met Val
                                                            1

 att gat ccc ctt cat gtg acc ctg aca cca aag aag ctg aag acc ggc      643
 Ile Asp Pro Leu His Val Thr Leu Thr Pro Lys Lys Leu Lys Thr Gly
           5                  10                  15

 att ggc agc acg gtc atc ctc tcc tgt gcc ctg acg ggc tcc cca gag      691
 Ile Gly Ser Thr Val Ile Leu Ser Cys Ala Leu Thr Gly Ser Pro Glu
      20                  25                  30

 ttc acc atc cgc tgg tat cgc aac acg gag ctg gtg ctg cct gac gag      739
 Phe Thr Ile Arg Trp Tyr Arg Asn Thr Glu Leu Val Leu Pro Asp Glu
  35                  40                  45                  50

 gcc atc tcc atc cgc ggg ctc agc aac gag acg ctg ctc atc acc tcg      787
 Ala Ile Ser Ile Arg Gly Leu Ser Asn Glu Thr Leu Leu Ile Thr Ser
                  55                  60                  65

 gcc cag aag agc cat tcc ggg gcc tac cag tgc ttc gct acc cgc aag      835
 Ala Gln Lys Ser His Ser Gly Ala Tyr Gln Cys Phe Ala Thr Arg Lys
              70                  75                  80

 gcc cag acc gcc cag gac ttt gcc atc att gca ctt gag gat ggc acg      883
 Ala Gln Thr Ala Gln Asp Phe Ala Ile Ile Ala Leu Glu Asp Gly Thr
          85                  90                  95

 ccc cgc atc gtc tcg tcc ttc agc gag aag gtg gtc aac ccc ggg gag      931
 Pro Arg Ile Val Ser Ser Phe Ser Glu Lys Val Val Asn Pro Gly Glu
     100                 105                 110

 cag ttc tca ctg atg tgt gcg gcc aag ggc gcc ccg ccc ccc acg gtc      979
 Gln Phe Ser Leu Met Cys Ala Ala Lys Gly Ala Pro Pro Pro Thr Val
 115                 120                 125                 130

 acc tgg gcc ctc gac gat gag ccc atc gtg cgg gat ggc agc cac cgc     1027
 Thr Trp Ala Leu Asp Asp Glu Pro Ile Val Arg Asp Gly Ser His Arg
                 135                 140                 145

 acc aac cag tac acc atg tcg gac ggc acc acc atc agc cac atg aac     1075
 Thr Asn Gln Tyr Thr Met Ser Asp Gly Thr Thr Ile Ser His Met Asn
             150                 155                 160

 gtc aca ggc ccc cag atc cgc gac ggg ggc gtg tac cgg tgc aca gcg     1123
 Val Thr Gly Pro Gln Ile Arg Asp Gly Gly Val Tyr Arg Cys Thr Ala
         165                 170                 175

 cgg aac ttg gtg ggc agt gct gaa tat cag gcg cga ata aac gta aga     1171
 Arg Asn Leu Val Gly Ser Ala Glu Tyr Gln Ala Arg Ile Asn Val Arg
     180                 185                 190

 ggc cca ccc agc atc cgg gct atg cgg aac atc aca gca gtc gcc ggg     1219
 Gly Pro Pro Ser Ile Arg Ala Met Arg Asn Ile Thr Ala Val Ala Gly
 195                 200                 205                 210

 cgg gac acc ctt atc aac tgc agg gtc atc ggc tat ccc tac tac tcc     1267
 Arg Asp Thr Leu Ile Asn Cys Arg Val Ile Gly Tyr Pro Tyr Tyr Ser
                 215                 220                 225

 atc aag tgg tac aag gat gcc ctg ctg ctg cca gac aac cac cgc cag     1315
 Ile Lys Trp Tyr Lys Asp Ala Leu Leu Leu Pro Asp Asn His Arg Gln
             230                 235                 240

 gtg gtg ttt gag aat ggg acc ctc aag ctg act gac gtg cag aag ggc     1363
 Val Val Phe Glu Asn Gly Thr Leu Lys Leu Thr Asp Val Gln Lys Gly
         245                 250                 255

 atg gat gag ggg gag tac ctg tgc agt gtc ctc atc cag ccc cag ctc     1411
 Met Asp Glu Gly Glu Tyr Leu Cys Ser Val Leu Ile Gln Pro Gln Leu
     260                 265                 270

 tcc atc agc cag agc gtt cac gta gcc gtc aaa gtg ccc cct ctg atc     1459
 Ser Ile Ser Gln Ser Val His Val Ala Val Lys Val Pro Pro Leu Ile
 275                 280                 285                 290

 cag ccc ttc gaa ttc cca ccc gcc tcc atc ggc cag ctg ctc tac att     1507
 Gln Pro Phe Glu Phe Pro Pro Ala Ser Ile Gly Gln Leu Leu Tyr Ile
                 295                 300                 305

 ccc tgt gtg gtg tcc tcg ggg gac atg ccc atc cgt atc acc tgg agg     1555
 Pro Cys Val Val Ser Ser Gly Asp Met Pro Ile Arg Ile Thr Trp Arg
             310                 315                 320

 aag gac gga cag gtg atc atc tca ggc tcg ggc gtg acc atc gag agc     1603
 Lys Asp Gly Gln Val Ile Ile Ser Gly Ser Gly Val Thr Ile Glu Ser
         325                 330                 335

 aag gaa ttc atg agc tcc ctg cag atc tct agc gtc tcc ctc aag cac     1651
 Lys Glu Phe Met Ser Ser Leu Gln Ile Ser Ser Val Ser Leu Lys His
     340                 345                 350

 aac ggc aac tat aca tgc atc gcc agc aac gca gcc gcc acc gtg agc     1699
 Asn Gly Asn Tyr Thr Cys Ile Ala Ser Asn Ala Ala Ala Thr Val Ser
 355                 360                 365                 370

 cgg gag cgc cag ctc atc gtg cgt gtg ccc cct cga ttt gtg gtg caa     1747
 Arg Glu Arg Gln Leu Ile Val Arg Val Pro Pro Arg Phe Val Val Gln
                 375                 380                 385

 ccc aac aac cag gat ggc atc tac ggc aaa gct ggt gtg ctc aac tgc     1795
 Pro Asn Asn Gln Asp Gly Ile Tyr Gly Lys Ala Gly Val Leu Asn Cys
             390                 395                 400

 tcg gtg gac ggc tac ccc cca ccc aag gtc atg tgg aag cat gcc aag     1843
 Ser Val Asp Gly Tyr Pro Pro Pro Lys Val Met Trp Lys His Ala Lys
         405                 410                 415

 ggg agc ggg aac ccc cag cag tac cac cct gtg ccc ctc act ggc cgc     1891
 Gly Ser Gly Asn Pro Gln Gln Tyr His Pro Val Pro Leu Thr Gly Arg
     420                 425                 430

 atc cag atc ctg ccc aac agc tcg ctg ctg atc cgc cac gtc cta gaa     1939
 Ile Gln Ile Leu Pro Asn Ser Ser Leu Leu Ile Arg His Val Leu Glu
 435                 440                 445                 450

 gag gac atc ggc tac tac ctc tgc cag gcc agc aac ggc gta ggc acc     1987
 Glu Asp Ile Gly Tyr Tyr Leu Cys Gln Ala Ser Asn Gly Val Gly Thr
                 455                 460                 465

 gac atc agc aag tcc atg ttc ctc aca gtc aag atc ccg gcc atg atc     2035
 Asp Ile Ser Lys Ser Met Phe Leu Thr Val Lys Ile Pro Ala Met Ile
             470                 475                 480

 act tcc cac ccc aac acc acc atc gcc atc aag ggc cat gcg aag gag     2083
 Thr Ser His Pro Asn Thr Thr Ile Ala Ile Lys Gly His Ala Lys Glu
         485                 490                 495

 cta aac tgc acg gca cgg ggt gag cgg ccc atc atc atc cgc tgg gag     2131
 Leu Asn Cys Thr Ala Arg Gly Glu Arg Pro Ile Ile Ile Arg Trp Glu
     500                 505                 510

 aag ggg gac aca gtc atc gac cct gac cgc gtc atg cgg tat gcc atc     2179
 Lys Gly Asp Thr Val Ile Asp Pro Asp Arg Val Met Arg Tyr Ala Ile
 515                 520                 525                 530

 gcc acc aag gac aac ggc gac gag gtc gtc tcc aca ctg aag ctc aag     2227
 Ala Thr Lys Asp Asn Gly Asp Glu Val Val Ser Thr Leu Lys Leu Lys
                 535                 540                 545

 ccc gct gac cgt ggg gac tct gtg ttc ttc agc tgc cat gcc atc aac     2275
 Pro Ala Asp Arg Gly Asp Ser Val Phe Phe Ser Cys His Ala Ile Asn
             550                 555                 560

 tcg tat ggg gag gac cgg ggc ttg atc caa ctc act gtg caa gag ccc     2323
 Ser Tyr Gly Glu Asp Arg Gly Leu Ile Gln Leu Thr Val Gln Glu Pro
         565                 570                 575

 ccc gac ccc cca gag ctg gag atc cgg gag gtg aag gcc cgg agc atg     2371
 Pro Asp Pro Pro Glu Leu Glu Ile Arg Glu Val Lys Ala Arg Ser Met
     580                 585                 590

 aac ctg cgc tgg acc cag cga ttc gac ggg aac agc atc atc acg ggc     2419
 Asn Leu Arg Trp Thr Gln Arg Phe Asp Gly Asn Ser Ile Ile Thr Gly
 595                 600                 605                 610

 ttc gac att gaa tac aag aac aaa tca gat tcc tgg gac ttc aag cag     2467
 Phe Asp Ile Glu Tyr Lys Asn Lys Ser Asp Ser Trp Asp Phe Lys Gln
                 615                 620                 625

 tcc aca cgc aac atc tcc ccc acc atc aac cag gcc aac att gtg gac     2515
 Ser Thr Arg Asn Ile Ser Pro Thr Ile Asn Gln Ala Asn Ile Val Asp
             630                 635                 640

 ttg cac ccg gca tct gtg tac agc atc cgc atg tac tct ttc aac aag     2563
 Leu His Pro Ala Ser Val Tyr Ser Ile Arg Met Tyr Ser Phe Asn Lys
         645                 650                 655

 att ggc cgc agt gaa cca agc aag gag ctc acc atc agc act gag gag     2611
 Ile Gly Arg Ser Glu Pro Ser Lys Glu Leu Thr Ile Ser Thr Glu Glu
     660                 665                 670

 gcc gct ccc gat ggg ccc ccc atg gat gtt acc ttg cag cca gtg acc     2659
 Ala Ala Pro Asp Gly Pro Pro Met Asp Val Thr Leu Gln Pro Val Thr
 675                 680                 685                 690

 tca cag agc atc cag gtg acc tgg aag gca ccc aag aag gag ctg cag     2707
 Ser Gln Ser Ile Gln Val Thr Trp Lys Ala Pro Lys Lys Glu Leu Gln
                 695                 700                 705

 aac ggt gtc atc cgg ggc tac cag att ggc tac aga gag aac agc ccc     2755
 Asn Gly Val Ile Arg Gly Tyr Gln Ile Gly Tyr Arg Glu Asn Ser Pro
             710                 715                 720

 ggc agc aac ggg cag tac agc atc gtg gag atg aag gcc acg ggg gac     2803
 Gly Ser Asn Gly Gln Tyr Ser Ile Val Glu Met Lys Ala Thr Gly Asp
         725                 730                 735

 agc gag gtc tac acc ctg gac aac ctc aag aag ttc gcc cag tat ggg     2851
 Ser Glu Val Tyr Thr Leu Asp Asn Leu Lys Lys Phe Ala Gln Tyr Gly
     740                 745                 750

 gtg gtg gtc caa gcc ttc aat cgg gct ggc acg ggg ccc tct tcc agc     2899
 Val Val Val Gln Ala Phe Asn Arg Ala Gly Thr Gly Pro Ser Ser Ser
 755                 760                 765                 770

 gag atc aat gcc acc act ctg gag gat gtg ccc agc cag ccc cct gag     2947
 Glu Ile Asn Ala Thr Thr Leu Glu Asp Val Pro Ser Gln Pro Pro Glu
                 775                 780                 785

 aac gtc cgg gcc ctg tcc atc act tct gac gtg gcc gtc atc tcc tgg     2995
 Asn Val Arg Ala Leu Ser Ile Thr Ser Asp Val Ala Val Ile Ser Trp
             790                 795                 800

 tca gag ccc ccg cgc agc acc ctc aat ggc gtc ctc aaa ggc tat cgg     3043
 Ser Glu Pro Pro Arg Ser Thr Leu Asn Gly Val Leu Lys Gly Tyr Arg
         805                 810                 815

 gtc atc ttc tgg tcc ctc tat gtt gat ggg gag tgg ggc gag atg cag     3091
 Val Ile Phe Trp Ser Leu Tyr Val Asp Gly Glu Trp Gly Glu Met Gln
     820                 825                 830

 aac atc acc acc acg cgg gag cgg gtg gag ctg cgg ggc atg gag aag     3139
 Asn Ile Thr Thr Thr Arg Glu Arg Val Glu Leu Arg Gly Met Glu Lys
 835                 840                 845                 850

 ttc acc aac tac agc gtc cag gtg ctg gcc tac acc cag gct ggg gac     3187
 Phe Thr Asn Tyr Ser Val Gln Val Leu Ala Tyr Thr Gln Ala Gly Asp
                 855                 860                 865

 ggc gta cgc agc agt gtg ctc tac atc cag acc aag gag gac gtt cca     3235
 Gly Val Arg Ser Ser Val Leu Tyr Ile Gln Thr Lys Glu Asp Val Pro
             870                 875                 880

 ggt ccc cct gct ggc atc aaa gct gtc cct tca tca gct agc agt gtg     3283
 Gly Pro Pro Ala Gly Ile Lys Ala Val Pro Ser Ser Ala Ser Ser Val
         885                 890                 895

 gtt gtg tct tgg ctc ccc cct acc aag ccc aac ggg gtg atc cgc aag     3331
 Val Val Ser Trp Leu Pro Pro Thr Lys Pro Asn Gly Val Ile Arg Lys
     900                 905                 910

 tac acc atc ttc tgt tcc agc ccc ggg tct ggc cag ccg gct ccc agc     3379
 Tyr Thr Ile Phe Cys Ser Ser Pro Gly Ser Gly Gln Pro Ala Pro Ser
 915                 920                 925                 930

 gag tac gag acg agt cca gag cag ctc ttc tac cgg atc gcc cac cta     3427
 Glu Tyr Glu Thr Ser Pro Glu Gln Leu Phe Tyr Arg Ile Ala His Leu
                 935                 940                 945

 aac cgc ggt cag cag tat ctg ctg tgg gtg gcc gcc gtc acc tct gcc     3475
 Asn Arg Gly Gln Gln Tyr Leu Leu Trp Val Ala Ala Val Thr Ser Ala
             950                 955                 960

 ggc cgg ggc aac agc agc gag aag gtg acc atc gag cct gct ggc aag     3523
 Gly Arg Gly Asn Ser Ser Glu Lys Val Thr Ile Glu Pro Ala Gly Lys
         965                 970                 975

 gcc cca gca aag atc atc tcc ttt ggg ggc acc gtg aca aca cct tgg     3571
 Ala Pro Ala Lys Ile Ile Ser Phe Gly Gly Thr Val Thr Thr Pro Trp
     980                 985                 990

 atg aaa gat gtt cgg ctg cct tgc aat tca gtg gga gat cca gcc cct     3619
 Met Lys Asp Val Arg Leu Pro Cys Asn Ser Val Gly Asp Pro Ala Pro
 995                1000                1005                1010

 gct gtg aag tgg acc aag gac agt gaa gac tcg gcc att cca gtg tcc     3667
 Ala Val Lys Trp Thr Lys Asp Ser Glu Asp Ser Ala Ile Pro Val Ser
                1015                1020                1025

 atg gat ggg cac cgg ctc atc cac acc aat ggc aca ctg ctg ctg cgt     3715
 Met Asp Gly His Arg Leu Ile His Thr Asn Gly Thr Leu Leu Leu Arg
            1030                1035                1040

 gca gtg aag gct gag gac tct ggc tac tac acg tgc acg gcc acc aac     3763
 Ala Val Lys Ala Glu Asp Ser Gly Tyr Tyr Thr Cys Thr Ala Thr Asn
        1045                1050                1055

 act ggt ggc ttt gac acc atc atc gtc aac ctt ctg gtg caa gtt ccc     3811
 Thr Gly Gly Phe Asp Thr Ile Ile Val Asn Leu Leu Val Gln Val Pro
    1060                1065                1070

 ccg gac cag ccc cgc ctc act gtc tcc aaa acc tca gct tcg tcc atc     3859
 Pro Asp Gln Pro Arg Leu Thr Val Ser Lys Thr Ser Ala Ser Ser Ile
1075                1080                1085                1090

 acc ctg acc tgg att cca ggt gac aat ggg ggc agc tcc atc cga ggc     3907
 Thr Leu Thr Trp Ile Pro Gly Asp Asn Gly Gly Ser Ser Ile Arg Gly
                1095                1100                1105

 ttc gtg cta cag tac tcg gtg gac aac agc gag gag tgg aag gat gtg     3955
 Phe Val Leu Gln Tyr Ser Val Asp Asn Ser Glu Glu Trp Lys Asp Val
            1110                1115                1120

 ttc atc agc tcc agc gag cgc tcc ttc aag ctg gac agc ctc aag tgt     4003
 Phe Ile Ser Ser Ser Glu Arg Ser Phe Lys Leu Asp Ser Leu Lys Cys
        1125                1130                1135

 ggc acg tgg tac aag gtg aag ctg gca gcc aag aac agc gtg ggc tct     4051
 Gly Thr Trp Tyr Lys Val Lys Leu Ala Ala Lys Asn Ser Val Gly Ser
    1140                1145                1150

 ggg cgc atc agc gag atc atc gag gcc aag acc cac ggg cgg gag ccc     4099
 Gly Arg Ile Ser Glu Ile Ile Glu Ala Lys Thr His Gly Arg Glu Pro
1155                1160                1165                1170

 tcc ttc agc aaa gac caa cac ctc ttc acc cac atc aac tcc acg cat     4147
 Ser Phe Ser Lys Asp Gln His Leu Phe Thr His Ile Asn Ser Thr His
                1175                1180                1185

 gct cgg ctt aac ctg cag ggc tgg aac aat ggg ggc tgc cct atc aca     4195
 Ala Arg Leu Asn Leu Gln Gly Trp Asn Asn Gly Gly Cys Pro Ile Thr
            1190                1195                1200

 gcc atc gtt ctg gag tac cgg ccc aag ggg acc tgg gcc tgg cag ggc     4243
 Ala Ile Val Leu Glu Tyr Arg Pro Lys Gly Thr Trp Ala Trp Gln Gly
        1205                1210                1215

 ctc cgg gcc aac agc tcc ggg gag gtg ttt ctg acg gaa ctg cga gag     4291
 Leu Arg Ala Asn Ser Ser Gly Glu Val Phe Leu Thr Glu Leu Arg Glu
    1220                1225                1230

 gcc acg tgg tac gag ctg cgc atg agg gct tgc aac agt gcg ggc tgc     4339
 Ala Thr Trp Tyr Glu Leu Arg Met Arg Ala Cys Asn Ser Ala Gly Cys
1235                1240                1245                1250

 ggc aat gaa aca gcc cag ttc gcc acc ctg gac tac gat ggc agc acc     4387
 Gly Asn Glu Thr Ala Gln Phe Ala Thr Leu Asp Tyr Asp Gly Ser Thr
                1255                1260                1265

 att cca ccc atc aag tct gct caa ggt gaa ggg gat gat gtg aag aag     4435
 Ile Pro Pro Ile Lys Ser Ala Gln Gly Glu Gly Asp Asp Val Lys Lys
            1270                1275                1280

 ctg ttc acc atc ggc tgc cct gtc atc ctg gcc aca ctg ggg gtg gca     4483
 Leu Phe Thr Ile Gly Cys Pro Val Ile Leu Ala Thr Leu Gly Val Ala
        1285                1290                1295

 ctg ctc ttc atc gta cgc aag aag agg aag gag aaa cgg ctg aag cga     4531
 Leu Leu Phe Ile Val Arg Lys Lys Arg Lys Glu Lys Arg Leu Lys Arg
    1300                1305                1310

 ctc cga gat gca aag agt ttg gca gaa atg ttg ata agc aag aac aat     4579
 Leu Arg Asp Ala Lys Ser Leu Ala Glu Met Leu Ile Ser Lys Asn Asn
1315                1320                1325                1330

 aga agc ttt gac acc cct gtg aaa ggg cca ccc cag ggc cca cgg cta     4627
 Arg Ser Phe Asp Thr Pro Val Lys Gly Pro Pro Gln Gly Pro Arg Leu
                1335                1340                1345

 cac att gac atc ccc agg gtc cag ctg ctc atc gag gac aaa gaa ggc     4675
 His Ile Asp Ile Pro Arg Val Gln Leu Leu Ile Glu Asp Lys Glu Gly
            1350                1355                1360

 atc aag caa ctg gga gat gac aag gcc acc atc cct gtg aca gat gct     4723
 Ile Lys Gln Leu Gly Asp Asp Lys Ala Thr Ile Pro Val Thr Asp Ala
        1365                1370                1375

 gag ttc agc caa gct gtc aac cca cag agc ttc tgt act ggc gtc tcc     4771
 Glu Phe Ser Gln Ala Val Asn Pro Gln Ser Phe Cys Thr Gly Val Ser
    1380                1385                1390

 ttg cac cac cca acc ctc atc cag agc aca gga ccc ctc atc gac atg     4819
 Leu His His Pro Thr Leu Ile Gln Ser Thr Gly Pro Leu Ile Asp Met
1395                1400                1405                1410

 tct gac atc cgg cca gga acc aat cca gtg tcc agg aag aat gtg aag     4867
 Ser Asp Ile Arg Pro Gly Thr Asn Pro Val Ser Arg Lys Asn Val Lys
                1415                1420                1425

 tca gcc cac agc acc cgg aac cgg tac tca agc cag tgg acc ctg acc     4915
 Ser Ala His Ser Thr Arg Asn Arg Tyr Ser Ser Gln Trp Thr Leu Thr
            1430                1435                1440

 aag tgc cag gcc tcc aca cct gcc cgc acc ctc acc tcc gac tgg cgc     4963
 Lys Cys Gln Ala Ser Thr Pro Ala Arg Thr Leu Thr Ser Asp Trp Arg
        1445                1450                1455

 acc gtg ggc tcc cag cat ggt gtc acg gtc act gag agt gac agc tac     5011
 Thr Val Gly Ser Gln His Gly Val Thr Val Thr Glu Ser Asp Ser Tyr
    1460                1465                1470

 agt gcc agc ctg tcc cag gac aca gac aaa gga agg aac agc atg gtg     5059
 Ser Ala Ser Leu Ser Gln Asp Thr Asp Lys Gly Arg Asn Ser Met Val
1475                1480                1485                1490

 tcc act gag agt gcc tct tcc acc tac gag gag ctg gcc cgg gcc tat     5107
 Ser Thr Glu Ser Ala Ser Ser Thr Tyr Glu Glu Leu Ala Arg Ala Tyr
                1495                1500                1505

 gag cat gcc aag ctg gag gag cag ctg cag cac gcc aag ttt gag atc     5155
 Glu His Ala Lys Leu Glu Glu Gln Leu Gln His Ala Lys Phe Glu Ile
            1510                1515                1520

 acc gag tgc ttc atc tct gac agt tcc tct gac cag atg acc aca ggc     5203
 Thr Glu Cys Phe Ile Ser Asp Ser Ser Ser Asp Gln Met Thr Thr Gly
        1525                1530                1535

 acc aac gag aac gcc gac agc atg aca tcc atg agc aca ccc tca gag     5251
 Thr Asn Glu Asn Ala Asp Ser Met Thr Ser Met Ser Thr Pro Ser Glu
    1540                1545                1550

 cct ggc atc tgc cgc ttt acc gcc tca cca ccc aag ccc cag gat gcg     5299
 Pro Gly Ile Cys Arg Phe Thr Ala Ser Pro Pro Lys Pro Gln Asp Ala
1555                1560                1565                1570

 gac cgg ggc aaa aac gtg gct gtg ccc atc cct cac cgg gcc aac aag     5347
 Asp Arg Gly Lys Asn Val Ala Val Pro Ile Pro His Arg Ala Asn Lys
                1575                1580                1585

 agt gac tac tgc aac ctg ccc ctg tat gcc aag tca gag gcc ttc ttt     5395
 Ser Asp Tyr Cys Asn Leu Pro Leu Tyr Ala Lys Ser Glu Ala Phe Phe
            1590                1595                1600

 cga aag gca gat gga cgt gag ccc tgc ccc gtg gtc cca ccc cgt gag     5443
 Arg Lys Ala Asp Gly Arg Glu Pro Cys Pro Val Val Pro Pro Arg Glu
        1605                1610                1615

 gcc tcc atc cgg aac ctg gct cga acc tac cac acc cag gct cgc cac     5491
 Ala Ser Ile Arg Asn Leu Ala Arg Thr Tyr His Thr Gln Ala Arg His
    1620                1625                1630

 ctg acc ctg gac cct gcc agc aag tcc ttg ggc ctt ccc cac cca ggg     5539
 Leu Thr Leu Asp Pro Ala Ser Lys Ser Leu Gly Leu Pro His Pro Gly
1635                1640                1645                1650

 gcc ccc gct gcc gcc tcc aca gcc acc tta cct cag agg act ctg gcc     5587
 Ala Pro Ala Ala Ala Ser Thr Ala Thr Leu Pro Gln Arg Thr Leu Ala
                1655                1660                1665

 atg cca gcc ccc cca gcc ggc aca gcc ccc cca gcc ccc ggc ccc acc     5635
 Met Pro Ala Pro Pro Ala Gly Thr Ala Pro Pro Ala Pro Gly Pro Thr
            1670                1675                1680

 cct gct gag cca ccc acc gcc ccc agc gct gcc cct ccg gcc ccc agc     5683
 Pro Ala Glu Pro Pro Thr Ala Pro Ser Ala Ala Pro Pro Ala Pro Ser
        1685                1690                1695

 acc gag cct cca cga gcc ggg ggc cca cac acc aaa atg ggg ggc tcc     5731
 Thr Glu Pro Pro Arg Ala Gly Gly Pro His Thr Lys Met Gly Gly Ser
    1700                1705                1710

 agg gac tcg ctt ctc gag atg agc aca tcg ggg gta ggg agg tct cag     5779
 Arg Asp Ser Leu Leu Glu Met Ser Thr Ser Gly Val Gly Arg Ser Gln
1715                1720                1725                1730

 aag cag ggg gcc ggg gcc tac tcc aaa tcc tac acc ctg gtg tag         5824
 Lys Gln Gly Ala Gly Ala Tyr Ser Lys Ser Tyr Thr Leu Val 
                1735                1740





      <210> 73
      <211> 2818
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (449)..(2815)

      <400> 73
 aaggatcctt aattaaatta atcccccccc cccccctggc tcgtctgaac ttgaagacac     60

 cccacattcc aagatgcccg aggttcctgg gaatgcctgg ggttcttcga tccggaaaat    120

 cctaccggca tcctcctagg gagggattat tattattatt tttctttaat ctggaagaga    180

 agagaacaag ttgtgctttt ccccccttct tcttgctaaa tgccatggat ataactgaat    240

 aagcggctca gggctttccc cgcgtggacg tccgaggcca ccatctgcct gcattcgccg    300

 gagccgccgg agggtttagc tcgagtctgt ctcgggcggg gaaggatgcg tggccgagcc    360

 ggggagcccg ggcgccccgc ggagccggcc tcggtgccac ccagccgggg gtagatgctg    420

 cctcgcccag gcgctgagtg accagacc   atg gag acc ctg ctt ggt ggc ctg     472
                                  Met Glu Thr Leu Leu Gly Gly Leu
                                    1               5

 cta gcg ttt ggc atg gcg ttt gcc gtg gtc gac gcc tgc ccc aag tac      520
 Leu Ala Phe Gly Met Ala Phe Ala Val Val Asp Ala Cys Pro Lys Tyr
      10                  15                  20

 tgt gtc tgc cag aat ctg tct gag tca ctg ggg acc ctg tgc ccc tcc      568
 Cys Val Cys Gln Asn Leu Ser Glu Ser Leu Gly Thr Leu Cys Pro Ser
  25                  30                  35                  40

 aag ggg ctg ctc ttt gta ccc cct gat att gac cgg cgg aca gtg gag      616
 Lys Gly Leu Leu Phe Val Pro Pro Asp Ile Asp Arg Arg Thr Val Glu
                  45                  50                  55

 ctg cgc ctg ggc ggc aac ttc atc atc cac atc agc cgc cag gac ttt      664
 Leu Arg Leu Gly Gly Asn Phe Ile Ile His Ile Ser Arg Gln Asp Phe
              60                  65                  70

 gcc aac atg acg ggg ctg gtg gac ctg acc ctg tcc agg aac acc atc      712
 Ala Asn Met Thr Gly Leu Val Asp Leu Thr Leu Ser Arg Asn Thr Ile
          75                  80                  85

 agc cac atc cag ccc ttt tcc ttt ctg gac ctc gag agc ctc cgc tcc      760
 Ser His Ile Gln Pro Phe Ser Phe Leu Asp Leu Glu Ser Leu Arg Ser
      90                  95                 100

 ctg cat ctt gac agc aat cgg ctg cca agc ctt ggg gag gac acc ctc      808
 Leu His Leu Asp Ser Asn Arg Leu Pro Ser Leu Gly Glu Asp Thr Leu
 105                 110                 115                 120

 cgg ggc ctg gtc aac ctg cag cac ctt atc gtg aac aac aac cag ctg      856
 Arg Gly Leu Val Asn Leu Gln His Leu Ile Val Asn Asn Asn Gln Leu
                 125                 130                 135

 ggc ggc atc gca gat gag gct ttt gag gac ttc ctg ctg aca ttg gag      904
 Gly Gly Ile Ala Asp Glu Ala Phe Glu Asp Phe Leu Leu Thr Leu Glu
             140                 145                 150

 gat ctg gac ctc tcc tac aac aac ctc cat ggc ctg ccg tgg gac tcc      952
 Asp Leu Asp Leu Ser Tyr Asn Asn Leu His Gly Leu Pro Trp Asp Ser
         155                 160                 165

 gtg cga cgc atg gtc aac ctc cac cag ctg agc ctg gac cac aac ctg     1000
 Val Arg Arg Met Val Asn Leu His Gln Leu Ser Leu Asp His Asn Leu
     170                 175                 180

 ctg gat cac atc gcc gag ggc acc ttt gca gac ctg cag aaa ctg gcc     1048
 Leu Asp His Ile Ala Glu Gly Thr Phe Ala Asp Leu Gln Lys Leu Ala
 185                 190                 195                 200

 cgc ctg gat ctc acc tcc aat cgg ctg cag aag ctg ccc cct gat ccc     1096
 Arg Leu Asp Leu Thr Ser Asn Arg Leu Gln Lys Leu Pro Pro Asp Pro
                 205                 210                 215

 atc ttt gcc cgc tcc cag gct tcg gct ttg aca gcc aca ccc ttt gcc     1144
 Ile Phe Ala Arg Ser Gln Ala Ser Ala Leu Thr Ala Thr Pro Phe Ala
             220                 225                 230

 cca ccc ttg tcc ttt agt ttt ggg ggt aac cca ctt cac tgc aat tgt     1192
 Pro Pro Leu Ser Phe Ser Phe Gly Gly Asn Pro Leu His Cys Asn Cys
         235                 240                 245

 gag ctt ctc tgg ctg cgg agg ctc gag cgg gac gat gac ctg gaa acc     1240
 Glu Leu Leu Trp Leu Arg Arg Leu Glu Arg Asp Asp Asp Leu Glu Thr
     250                 255                 260

 tgt ggc tcc cca ggg ggc ctc aag ggt cgc tac ttc tgg cat gtg cgt     1288
 Cys Gly Ser Pro Gly Gly Leu Lys Gly Arg Tyr Phe Trp His Val Arg
 265                 270                 275                 280

 gag gag gag ttt gtg tgc gag ccg cct ctc atc acc cag cac aca cac     1336
 Glu Glu Glu Phe Val Cys Glu Pro Pro Leu Ile Thr Gln His Thr His
                 285                 290                 295

 aag ttg ctg gtt ctg gag ggc cag gcg gcc aca ctc aag tgc aaa gcc     1384
 Lys Leu Leu Val Leu Glu Gly Gln Ala Ala Thr Leu Lys Cys Lys Ala
             300                 305                 310

 att ggg gac ccc agc ccc ctt atc cac tgg gta gcc ccc gat gac cgc     1432
 Ile Gly Asp Pro Ser Pro Leu Ile His Trp Val Ala Pro Asp Asp Arg
         315                 320                 325

 ctg gta ggg aac tcc tca agg acc gct gtc tat gac aat ggc acc ccg     1480
 Leu Val Gly Asn Ser Ser Arg Thr Ala Val Tyr Asp Asn Gly Thr Pro
     330                 335                 340

 gac atc ttc atc acc aca tct cag gac agt ggt gcc ttc acc tgc att     1528
 Asp Ile Phe Ile Thr Thr Ser Gln Asp Ser Gly Ala Phe Thr Cys Ile
 345                 350                 355                 360

 gct gcc aat gct gcc gga gag gcc acg gcc atg gtg gag gtc tcc atc     1576
 Ala Ala Asn Ala Ala Gly Glu Ala Thr Ala Met Val Glu Val Ser Ile
                 365                 370                 375

 gtc cag ctg cca cac ctc agc aac agc acc agc cgc act gca ccc ccc     1624
 Val Gln Leu Pro His Leu Ser Asn Ser Thr Ser Arg Thr Ala Pro Pro
             380                 385                 390

 aag tcc cgc ctc tca gac atc act ggc tcc agc aag acc agc cgg gga     1672
 Lys Ser Arg Leu Ser Asp Ile Thr Gly Ser Ser Lys Thr Ser Arg Gly
         395                 400                 405

 ggt gga ggc agt ggg ggc gga gag cct ccc aaa agc ccc ccg gaa cgg     1720
 Gly Gly Gly Ser Gly Gly Gly Glu Pro Pro Lys Ser Pro Pro Glu Arg
     410                 415                 420

 gct gtg ctt gtg tct gaa gtg acc acc acc tcg gcc ctg gtc aag tgg     1768
 Ala Val Leu Val Ser Glu Val Thr Thr Thr Ser Ala Leu Val Lys Trp
 425                 430                 435                 440

 tct gtc agc aag tca gca ccc cgg gtg aag atg tac cag ctg cag tac     1816
 Ser Val Ser Lys Ser Ala Pro Arg Val Lys Met Tyr Gln Leu Gln Tyr
                 445                 450                 455

 aac tgc tct gac gat gag gta ctg att tac agg atg atc cca gcc tcc     1864
 Asn Cys Ser Asp Asp Glu Val Leu Ile Tyr Arg Met Ile Pro Ala Ser
             460                 465                 470

 aac aag gcc ttc gtg gtc aac aac ctg gtg tca ggg act ggc tac gac     1912
 Asn Lys Ala Phe Val Val Asn Asn Leu Val Ser Gly Thr Gly Tyr Asp
         475                 480                 485

 ttg tgt gtg ctg gcc atg tgg gat gac aca gcc acg aca ctc acg gcc     1960
 Leu Cys Val Leu Ala Met Trp Asp Asp Thr Ala Thr Thr Leu Thr Ala
     490                 495                 500

 acc aac atc gtg ggc tgc gcc cag ttc ttc acc aag gct gac tac ccg     2008
 Thr Asn Ile Val Gly Cys Ala Gln Phe Phe Thr Lys Ala Asp Tyr Pro
 505                 510                 515                 520

 cag tgc cag tcc atg cac agc cag att ctg ggc ggc acc atg atc ctg     2056
 Gln Cys Gln Ser Met His Ser Gln Ile Leu Gly Gly Thr Met Ile Leu
                 525                 530                 535

 gtc atc ggg ggc atc atc gtg gcc acg ctg ctg gtc ttc atc gtc atc     2104
 Val Ile Gly Gly Ile Ile Val Ala Thr Leu Leu Val Phe Ile Val Ile
             540                 545                 550

 ctc atg gtg cgc tac aag gtc tgc aac cac gag gcc ccc agc aag atg     2152
 Leu Met Val Arg Tyr Lys Val Cys Asn His Glu Ala Pro Ser Lys Met
         555                 560                 565

 gca gcg gcc gtg agc aat gtg tac tcg cag acc aac ggc gcc cag cca     2200
 Ala Ala Ala Val Ser Asn Val Tyr Ser Gln Thr Asn Gly Ala Gln Pro
     570                 575                 580

 ccg cct cca agc agc gca cca gcc ggg gcc ccg ccg cag ggc ccg ccg     2248
 Pro Pro Pro Ser Ser Ala Pro Ala Gly Ala Pro Pro Gln Gly Pro Pro
 585                 590                 595                 600

 aag gtg gtg gtg cgc aac gag ctc ctg gac ttc acc gcc agc ctg gcc     2296
 Lys Val Val Val Arg Asn Glu Leu Leu Asp Phe Thr Ala Ser Leu Ala
                 605                 610                 615

 cgc gcc agt gac tcc tct tcc tcc agc tcc ctg ggc agt ggg gag gct     2344
 Arg Ala Ser Asp Ser Ser Ser Ser Ser Ser Leu Gly Ser Gly Glu Ala
             620                 625                 630

 gcg ggg ctg gga cgg gcc ccc tgg agg atc cca ccc tcc gcc ccg cgc     2392
 Ala Gly Leu Gly Arg Ala Pro Trp Arg Ile Pro Pro Ser Ala Pro Arg
         635                 640                 645

 ccc aag ccc agc ctt gac cgc ctg atg ggg gcc ttc gcc tcc ctg gac     2440
 Pro Lys Pro Ser Leu Asp Arg Leu Met Gly Ala Phe Ala Ser Leu Asp
     650                 655                 660

 ctc aag agt cag aga aag gag gag ctg ctg gac tcc agg act cca gcc     2488
 Leu Lys Ser Gln Arg Lys Glu Glu Leu Leu Asp Ser Arg Thr Pro Ala
 665                 670                 675                 680

 ggg aga ggg gct ggg acg tcg gcc cgg ggc cac cac tcg gac cga gag     2536
 Gly Arg Gly Ala Gly Thr Ser Ala Arg Gly His His Ser Asp Arg Glu
                 685                 690                 695

 cca ctg ctg ggg ccc cct gcg gcc cgg gcc agg agc ctg ctc ccc ttg     2584
 Pro Leu Leu Gly Pro Pro Ala Ala Arg Ala Arg Ser Leu Leu Pro Leu
             700                 705                 710

 ccg ttg gag ggc aag gcc aaa cgc agc cac tcc ttc gac atg ggg gac     2632
 Pro Leu Glu Gly Lys Ala Lys Arg Ser His Ser Phe Asp Met Gly Asp
         715                 720                 725

 ttt gct gct gcg gcg gcg gga ggg gtc gtg ccg ggc ggc tac agt cct     2680
 Phe Ala Ala Ala Ala Ala Gly Gly Val Val Pro Gly Gly Tyr Ser Pro
     730                 735                 740

 cct cgg aag gtc tcg aac atc tgg acg aag cgc agc ctc tct gtc aac     2728
 Pro Arg Lys Val Ser Asn Ile Trp Thr Lys Arg Ser Leu Ser Val Asn
 745                 750                 755                 760

 ggc atg ctc ttg ccc ttt gag gag agt gac ctg gtg ggg gcc cgg ggg     2776
 Gly Met Leu Leu Pro Phe Glu Glu Ser Asp Leu Val Gly Ala Arg Gly
                 765                 770                 775

 act ttt ggc agc tcc gaa tgg gtg atg gag agc acg gtc tag             2818
 Thr Phe Gly Ser Ser Glu Trp Val Met Glu Ser Thr Val 
             780                 785





      <210> 74
      <211> 2506
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (79)..(1557)

      <400> 74
 acagcctgaa tagaagggct ggtccagcgg cggcggaggc tggcgctgtc ctgagaggga     60

 gggctctgtg cggaagag  atg aat cgg aca aag ggt gat gag gag gag tat     111
                      Met Asn Arg Thr Lys Gly Asp Glu Glu Glu Tyr
                        1               5                  10

 tgg aac agc tcc aag ttc aag gct ttt acc ttt gac gat gaa gac gat      159
 Trp Asn Ser Ser Lys Phe Lys Ala Phe Thr Phe Asp Asp Glu Asp Asp
              15                  20                  25

 gag ctt tca cag tta aag gag tcc aag cgg gcg gtg aac agc ctc cga      207
 Glu Leu Ser Gln Leu Lys Glu Ser Lys Arg Ala Val Asn Ser Leu Arg
          30                  35                  40

 gac ttc gtg gat gat gat gac gat gat gac ctg gag cga gtc agc tgg      255
 Asp Phe Val Asp Asp Asp Asp Asp Asp Asp Leu Glu Arg Val Ser Trp
      45                  50                  55

 agt ggg gaa cct gtg gga agt atc tca tgg tcc atc aga gag act gct      303
 Ser Gly Glu Pro Val Gly Ser Ile Ser Trp Ser Ile Arg Glu Thr Ala
  60                  65                  70                  75

 ggt aat agc ggc tca acc cac gag ggg cgt gaa cag cta aag agc cga      351
 Gly Asn Ser Gly Ser Thr His Glu Gly Arg Glu Gln Leu Lys Ser Arg
                  80                  85                  90

 aac agc ttc tcc tcc tat gca caa cta ccc aag cct act tct acc tac      399
 Asn Ser Phe Ser Ser Tyr Ala Gln Leu Pro Lys Pro Thr Ser Thr Tyr
              95                 100                 105

 tcc ctg agc agc ttt ttt aga ggt aga act aga cct gga agt ttc cag      447
 Ser Leu Ser Ser Phe Phe Arg Gly Arg Thr Arg Pro Gly Ser Phe Gln
         110                 115                 120

 tcc ctt tct gat gct ctg tca gac aca cct gcc aaa agc tat gct cca      495
 Ser Leu Ser Asp Ala Leu Ser Asp Thr Pro Ala Lys Ser Tyr Ala Pro
     125                 130                 135

 gag ctg ggg aga ccc aaa ggg gag tat agg gat tac agc aat gac tgg      543
 Glu Leu Gly Arg Pro Lys Gly Glu Tyr Arg Asp Tyr Ser Asn Asp Trp
 140                 145                 150                 155

 agc ccc agt gat aca gtg cga cgt ctc cgg aag ggc aag gtt tgc tca      591
 Ser Pro Ser Asp Thr Val Arg Arg Leu Arg Lys Gly Lys Val Cys Ser
                 160                 165                 170

 cta gag aga ttc cgc tcc tta cag gac aaa cta caa ctc cta gaa gag      639
 Leu Glu Arg Phe Arg Ser Leu Gln Asp Lys Leu Gln Leu Leu Glu Glu
             175                 180                 185

 gca gta agc atg cat gat gga aac gtc att act gca gtt ctg att ttc      687
 Ala Val Ser Met His Asp Gly Asn Val Ile Thr Ala Val Leu Ile Phe
         190                 195                 200

 ctg aag agg aca ctg agc aaa gag atc ctc ttc cga gag ctg gag gtg      735
 Leu Lys Arg Thr Leu Ser Lys Glu Ile Leu Phe Arg Glu Leu Glu Val
     205                 210                 215

 cga cag gtt gcc ctg aga cat ctt att cac ttc ctt aag gaa ata ggg      783
 Arg Gln Val Ala Leu Arg His Leu Ile His Phe Leu Lys Glu Ile Gly
 220                 225                 230                 235

 gat caa aag ttg ctt tta gac ctc ttc agg ttc cta gat aga aca gaa      831
 Asp Gln Lys Leu Leu Leu Asp Leu Phe Arg Phe Leu Asp Arg Thr Glu
                 240                 245                 250

 gag ctt gcg cta tct cat tat cga gag cat ttg aac att cag gac cct      879
 Glu Leu Ala Leu Ser His Tyr Arg Glu His Leu Asn Ile Gln Asp Pro
             255                 260                 265

 gac aaa cga aaa gaa ttt ctt aaa acc tgt gtt ggt ttg cca ttt tca      927
 Asp Lys Arg Lys Glu Phe Leu Lys Thr Cys Val Gly Leu Pro Phe Ser
         270                 275                 280

 gca gaa gat tcc gca cac ata cag gac cat tac acg ctc ctg gaa cgt      975
 Ala Glu Asp Ser Ala His Ile Gln Asp His Tyr Thr Leu Leu Glu Arg
     285                 290                 295

 cag atc att att gag gca aat gat cgc cat cta gaa tca gca gga cag     1023
 Gln Ile Ile Ile Glu Ala Asn Asp Arg His Leu Glu Ser Ala Gly Gln
 300                 305                 310                 315

 act gag atc ttc cga aag cac ccc cgc aaa gcc tcc atc ctc aac atg     1071
 Thr Glu Ile Phe Arg Lys His Pro Arg Lys Ala Ser Ile Leu Asn Met
                 320                 325                 330

 cca cta gtg aca aca ctt ttc tac tcc tgc ttc tat cac tac aca gag     1119
 Pro Leu Val Thr Thr Leu Phe Tyr Ser Cys Phe Tyr His Tyr Thr Glu
             335                 340                 345

 gct gag ggg aca ttc agc agt ccc gtc aac ctg aag aag aca ttt aag     1167
 Ala Glu Gly Thr Phe Ser Ser Pro Val Asn Leu Lys Lys Thr Phe Lys
         350                 355                 360

 atc cca gat aaa cag tat gtg ctg aca gcc ctg gct gct cgt gcc aag     1215
 Ile Pro Asp Lys Gln Tyr Val Leu Thr Ala Leu Ala Ala Arg Ala Lys
     365                 370                 375

 ctt cga gcc tgg aat gat gta gat gcc cta ttc acc aca aag aac tgg     1263
 Leu Arg Ala Trp Asn Asp Val Asp Ala Leu Phe Thr Thr Lys Asn Trp
 380                 385                 390                 395

 ctg ggc tat acc aag aag aga gca ccc att ggc ttc cat cgg gtt gtc     1311
 Leu Gly Tyr Thr Lys Lys Arg Ala Pro Ile Gly Phe His Arg Val Val
                 400                 405                 410

 gaa att ttg cac aag aac aat gcc cct gtg cag ata tta cag gag tat     1359
 Glu Ile Leu His Lys Asn Asn Ala Pro Val Gln Ile Leu Gln Glu Tyr
             415                 420                 425

 gtc aat ctg gtg gaa gat gtg gac acg aag ttg aac tta gcc act aag     1407
 Val Asn Leu Val Glu Asp Val Asp Thr Lys Leu Asn Leu Ala Thr Lys
         430                 435                 440

 ttc aag tgc cat gat gtc gtc att gat acc tac cgg gac ctg aag gat     1455
 Phe Lys Cys His Asp Val Val Ile Asp Thr Tyr Arg Asp Leu Lys Asp
     445                 450                 455

 cgt caa cag ttg cta gca tac agg agt aag gta gat aaa gga tca gca     1503
 Arg Gln Gln Leu Leu Ala Tyr Arg Ser Lys Val Asp Lys Gly Ser Ala
 460                 465                 470                 475

 gag gag gag aag att gat gct ctt ctc agc agc tcg caa att cga tgg     1551
 Glu Glu Glu Lys Ile Asp Ala Leu Leu Ser Ser Ser Gln Ile Arg Trp
                 480                 485                 490

 aag aat taagtggcat tgactacctt gaagcctgcc tcatttcctc ctctcctgcc      1607
 Lys Asn 


 tgtgaaagca gagagagctc ttctttggga gagctgcggc atcacatcgc ttgggcccat   1667

 tacccatggg cagtgccagc tactcttgac acagataact tcagactgat cttctgtcca   1727

 aggaacatca tctgaggatc gagatctaaa gctttgagtc atgagaatga ttctctccac   1787

 ctggtgctca tatgaaggtg ggagtgattt ctagattggg cccctactgg gtaagatctc   1847

 acttggtctg agaaaagtga ctgctccaga aaggaagagg tatgggagtc atagggtggc   1907

 tactgcattc cactcagcta attatgatcc aggacttggc gctggacatt ggcagttctg   1967

 ctctgaatga agtcagaaca gaaccaaaat ggcctcagga aggaatgcca gtgtttccca   2027

 agacctcctg gagatgcact cacaccagac tgcacagacc cctccacatt atgccacaca   2087

 cggcctagac gttgtgtttc ctcagccatt ttccctctgc tgccccagtt tactctgtcc   2147

 aaaaccctaa ggttcttctc tcacttgaac acagacgacc ttgcttgggt gatgagacat   2207

 cccctttatc tcttcctcta ctgctggcca agacccgtca ctttataaga agctcagatg   2267

 cagcagtgct ggagagctct ctctttatgc aaaaatctca tttcaccagg agctttcaga   2327

 agtttcacct gggctaaatt cagcagcatt tctgttagga tatttagatg gaggttttat   2387

 tttcacactt ggattcttgc tctgtaccaa tatttgcctc cttttctgtg actgaactgg   2447

 gtttttctga catgcctaga ctcctaataa aggtatttct tccttggaaa aaaaaaaaa    2506




      <210> 75
      <211> 496
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (44)..(262)

      <400> 75
 ctactaaatt cgcggccggt cgactttttt tttttttttt gag  atg gag tct cgc      55
                                                  Met Glu Ser Arg
                                                    1

 tct gtc acc cag gct gga gtg cag tgg cgc tat ctc agc tca ctg caa      103
 Ser Val Thr Gln Ala Gly Val Gln Trp Arg Tyr Leu Ser Ser Leu Gln
   5                  10                  15                  20

 gct tgg cct cca ggg ttc acg cca ttc tcc tgc ctc agc ctc ccg agt      151
 Ala Trp Pro Pro Gly Phe Thr Pro Phe Ser Cys Leu Ser Leu Pro Ser
                  25                  30                  35

 agc tgg gac tac agg cat ccg cca cca cgc ccg gct aat ttt ttg tat      199
 Ser Trp Asp Tyr Arg His Pro Pro Pro Arg Pro Ala Asn Phe Leu Tyr
              40                  45                  50

 ttt tct tta gta gag acg gag ttt cag cgt gct agc cag gat ggt ctc      247
 Phe Ser Leu Val Glu Thr Glu Phe Gln Arg Ala Ser Gln Asp Gly Leu
          55                  60                  65

 aat ctc ctg acc tcg tgatctgcct gcctcggcct cccagagtgc tgggattaca      302
 Asn Leu Leu Thr Ser 
      70

 ggtgtgaagc agctgtgccg ggaggatgag ggccgtagaa gggtttgtgt gagaaaaggg    362

 atgtgctggg gatccagggt gggggggcag gggcgtgatt ggggcgcagt gagagctgag    422

 gctgccgggg agagagagtc tgcggagtta aggtgcccga ggagtgtggg ccaaagttgt    482

 ggggaagaaa gcgg                                                      496




      <210> 76
      <211> 646
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (134)..(406)

      <400> 76
 ctgtgctgtg tagatggaga tgaattgttt ctaattttta gctaatacag ataaagatac     60

 tatgaatatt catgtataag tttttatatg gacatatgca ttcttttctt ttgagtgaat    120

 tcctgggaat gga   atg gta ggt aga ttt ttt tta ctt ttt gtt ttt tat     169
                  Met Val Gly Arg Phe Phe Leu Leu Phe Val Phe Tyr
                    1               5                  10

 ttt att ttt ttt ttt tta ttt ttt ttt aag aca gag tct cac tct gtt      217
 Phe Ile Phe Phe Phe Leu Phe Phe Phe Lys Thr Glu Ser His Ser Val
          15                  20                  25

 gtc cag gct gga gtg cag tgg tgc aat ctt ggc tca ctg caa cct cca      265
 Val Gln Ala Gly Val Gln Trp Cys Asn Leu Gly Ser Leu Gln Pro Pro
      30                  35                  40

 cct ccc agg ttc aag caa ttc tcc tgc cac agc ctc ata agt agc tgg      313
 Pro Pro Arg Phe Lys Gln Phe Ser Cys His Ser Leu Ile Ser Ser Trp
  45                  50                  55                  60

 gat tac agg agt gtg cca cca agc cca ggt aat ttt tta att ttt agt      361
 Asp Tyr Arg Ser Val Pro Pro Ser Pro Gly Asn Phe Leu Ile Phe Ser
                  65                  70                  75

 agc aaa tgg ggt ttc acc atg gtg gcc agg ctg gtc tgg aac tcc tga      409
 Ser Lys Trp Gly Phe Thr Met Val Ala Arg Leu Val Trp Asn Ser 
              80                  85                  90

 cctcaagtga tccacccgcc ttgacctccc aaagtgctgg gattacagac gtgagccacc    469

 acgcccagcc tttttttatt ttttaagaag ctgctaaaac cgttttccaa agtagttatt    529

 aacaggtaat tgaataacaa aattgtggta tatctataca atggaatact cctcagcaat    589

 atttgtgaca aagtggatga accccagaac aattacgcta tgtgaaagaa gccagac       646




      <210> 77
      <211> 968
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (679)..(918)

      <220>
      <221> misc_feature
      <222> (1)...(968)
      <223> n = a,t,c or g

      <400> 77
 aaaaaaaaaa aaactgaatg tcaaacccna cccctgttcc gggccccgca ataatagaaa     60

 agtaaacttt gaaaatgatg aaatctgggc ccctgtgcca aggttgtcac gccctgtaat    120

 ccccagcact ttgggaggct gaggcaggca aattgcttga gcccaagggt ttcccagtcc    180

 caacctgggt aacatactga gaccctgtct ccacaaaaaa tacaaaaatt agccaggtgt    240

 ggtggtgtgc tcctgtagtc ccagctactt gggggcttag atgggaggat cacttgagct    300

 caggaggtgg tggctgcagt gagccatgat tgtgggattg gacttcagcc tggatgacag    360

 agtgagatcc tgtctcaaaa aaaaaaaaat caatcttttt ttttgttctt catttctttc    420

 tgcctttgac agccccttcc tgtctataaa actaacctct tctacccagc tcattgcagc    480

 actctctgta ttttatggag tgaatctgtt cctgattcaa tgagtctgtt gcctgattct    540

 agaattgcca ataacgctaa ttgagacctt taaactaaat ttgttgtaat ctggtgtttt    600

 gacaggctgc tgctctgagg gaggtggaag taaaggccga gagtatcagg atcactctgg    660

 ctgctaggtg cagatgag  atg gga gga gag caa gag aga gga agg aca ggg     711
                      Met Gly Gly Glu Gln Glu Arg Gly Arg Thr Gly
                        1               5                  10

 gcc agt tgg aaa act att aca gca att ctc cag cct ggc caa cat ggt      759
 Ala Ser Trp Lys Thr Ile Thr Ala Ile Leu Gln Pro Gly Gln His Gly
              15                  20                  25

 gaa act ctg ttt cta ata aaa aca caa aaa tta ggg cca ggc atg gtg      807
 Glu Thr Leu Phe Leu Ile Lys Thr Gln Lys Leu Gly Pro Gly Met Val
          30                  35                  40

 gct cac acc tgt aat ccc agc act ttg gga ggc caa ggc ggg tgg atc      855
 Ala His Thr Cys Asn Pro Ser Thr Leu Gly Gly Gln Gly Gly Trp Ile
      45                  50                  55

 cca agg tca aga gat cga gat cat cct ggc caa cgc agt gaa acc cca      903
 Pro Arg Ser Arg Asp Arg Asp His Pro Gly Gln Arg Ser Glu Thr Pro
  60                  65                  70                  75

 tct cta cta aaa tta taaaaattag ctgtgcgtgg tggcacgcgc atgtagttcc      958
 Ser Leu Leu Lys Leu 
                  80

 agctactcag                                                           968




      <210> 78
      <211> 2126
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (21)..(965)

      <400> 78
 accggctcgc gagcgcagct    atg gct gct ggc gta ccc tgt gcg tta gtc      50
                          Met Ala Ala Gly Val Pro Cys Ala Leu Val
                            1               5                  10

 acc agc tgc tcc tcc gtc ttc tca gga gac cag ctg gtc caa cat atc       98
 Thr Ser Cys Ser Ser Val Phe Ser Gly Asp Gln Leu Val Gln His Ile
                  15                  20                  25

 ctt gga aca gaa gat ctt att gtg gaa gtg act tcc aat gat gct gtg      146
 Leu Gly Thr Glu Asp Leu Ile Val Glu Val Thr Ser Asn Asp Ala Val
              30                  35                  40

 aga ttt tat ccc tgg acc att gat aat aaa tac tat tca gca gac atc      194
 Arg Phe Tyr Pro Trp Thr Ile Asp Asn Lys Tyr Tyr Ser Ala Asp Ile
          45                  50                  55

 aat cta tgt gtg gtg cca aac aaa ttt ctt gtt act gca gag att gca      242
 Asn Leu Cys Val Val Pro Asn Lys Phe Leu Val Thr Ala Glu Ile Ala
      60                  65                  70

 gaa tct gtc caa gca ttt gtg gtt tac ttt gac agc aca caa aaa tcg      290
 Glu Ser Val Gln Ala Phe Val Val Tyr Phe Asp Ser Thr Gln Lys Ser
  75                  80                  85                  90

 ggc ctt gat agt gtc tcc tca tgg ctt cca ctg gca aaa gca tgg tta      338
 Gly Leu Asp Ser Val Ser Ser Trp Leu Pro Leu Ala Lys Ala Trp Leu
                  95                 100                 105

 cct gag gtg atg atc ttg gtc tgc gat aga gtg tct gaa gat ggt ata      386
 Pro Glu Val Met Ile Leu Val Cys Asp Arg Val Ser Glu Asp Gly Ile
             110                 115                 120

 aac cga caa aaa gct caa gaa tgg tgc atc aaa cat ggc ttt gaa ttg      434
 Asn Arg Gln Lys Ala Gln Glu Trp Cys Ile Lys His Gly Phe Glu Leu
         125                 130                 135

 gta gaa ctt agt cca gag gag ttg cct gag gag gat gat gac ttc cca      482
 Val Glu Leu Ser Pro Glu Glu Leu Pro Glu Glu Asp Asp Asp Phe Pro
     140                 145                 150

 gaa tct aca gga gta aag cga att gtc caa gcc ctg aat gcc aat gtg      530
 Glu Ser Thr Gly Val Lys Arg Ile Val Gln Ala Leu Asn Ala Asn Val
 155                 160                 165                 170

 tgg tcc aat gta gtg atg aag aat gat agg aac caa ggc ttt agc ctt      578
 Trp Ser Asn Val Val Met Lys Asn Asp Arg Asn Gln Gly Phe Ser Leu
                 175                 180                 185

 ctc aac tca ttg act gga aca aac cat agc att ggg tca gca gat ccc      626
 Leu Asn Ser Leu Thr Gly Thr Asn His Ser Ile Gly Ser Ala Asp Pro
             190                 195                 200

 tgt cac cca gag caa ccc cat ttg cca gca gca gat agt act gaa tcc      674
 Cys His Pro Glu Gln Pro His Leu Pro Ala Ala Asp Ser Thr Glu Ser
         205                 210                 215

 ctc tct gat cat cgg ggt ggt gca tct aac aca aca gat gcc cag gtt      722
 Leu Ser Asp His Arg Gly Gly Ala Ser Asn Thr Thr Asp Ala Gln Val
     220                 225                 230

 gat agc att gtg gat ccc atg tta gat ctg gat att caa gaa tta gcc      770
 Asp Ser Ile Val Asp Pro Met Leu Asp Leu Asp Ile Gln Glu Leu Ala
 235                 240                 245                 250

 agt ctt acc act gga gga gga gat gtg gag aat ttt gaa aga ctc ttt      818
 Ser Leu Thr Thr Gly Gly Gly Asp Val Glu Asn Phe Glu Arg Leu Phe
                 255                 260                 265

 tca aag tta aag gaa atg aaa gac aag gct gcg acg ctt cct cat gag      866
 Ser Lys Leu Lys Glu Met Lys Asp Lys Ala Ala Thr Leu Pro His Glu
             270                 275                 280

 caa aga aaa gtg cat gca gaa aag gtg gcc aaa gca ttc tgg atg gca      914
 Gln Arg Lys Val His Ala Glu Lys Val Ala Lys Ala Phe Trp Met Ala
         285                 290                 295

 atc ggg gga gac aga gat gaa att gaa ggc ctt tca tct gat gaa gag      962
 Ile Gly Gly Asp Arg Asp Glu Ile Glu Gly Leu Ser Ser Asp Glu Glu
     300                 305                 310

 cac tgaa ttattcatac tagggtttga ccaacaaaga tgctagctgt ctctgagata     1019
 His 
 315

 cctctctact cagcccagtc atattttgcc aaaattgccc ttatcatgtt ggctgcctga   1079

 cttgtttata gggtcccctt aattttagtt tttagtagga ggttaaggag aaatcttttt   1139

 tttcctcagt atattgtaag agagtgagga atacagtgat agtaatgagt gaggatttct   1199

 taaatatact ttttttttgt tctaggaatg agggtaggat aaatctcaga ggtctgtgtg   1259

 atttactcaa gttgaagaca acctccaggc cattcctggt caacctttta agtagcattt   1319

 ccagcattca cacttgatac tgcacatcag gagttgtgtc acctttcctg ggtgatttgg   1379

 gttttctcca ttcaaggagc ttgtagctct gagctatgat gcttttattg ggaggaaagg   1439

 aggcagctgc agaattgatg tgagctatgt ggggccgaag tctcagcccg cagctaagtc   1499

 tctacctaag aaaatgcctc tgggcattct tttgaagtat agtgtctgag ctcatgctag   1559

 aaagaatcaa aaagccagtg tggattttta gactgtaata aatgaggcaa aggatttcta   1619

 ttccagtggg aagaaaacct ctctactgag ttgtggggga tatgttgtat gttagagaga   1679

 accttaagga gtccttgtat gggccatgga gacagtatgt gataacatac cgtgattttc   1739

 atgaagaaat tcttctgtct tagagttctc ccctgctgct tgagatgcca gagctgtgtt   1799

 gttgcacacc tgcaaaacaa ggcacatttc cccctttctc tttaaagcca aagagagatc   1859

 actgccaaag tgggagcact aaggggtggg tggggaagtg aaatgttagg cgatgaattc   1919

 ctgagcacct tgtttttctt ccaaggttcg tagctcctct ctgcccttcc aagcctgtaa   1979

 cctcggagga ctatcttttg ttctttatcc tttgtcttgt ttgagtgggt cagccccaga   2039

 ggaactgata agcaaatggc aagtttttaa aggaagagtg gaaagtactg caaataaaaa   2099

 tccttatttg tttttgtaaa aaaaaaa                                       2126




      <210> 79
      <211> 1014
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (20)..(871)

      <400> 79
 ggcggctccg ggagccaac atg cct cgg tat gcg cag ctg gtc atg ggc ccc      52
                      Met Pro Arg Tyr Ala Gln Leu Val Met Gly Pro
                        1               5                  10

 gcg ggc agc ggg aag agc acc tac tgt gcc acc atg gtc cag cac tgt      100
 Ala Gly Ser Gly Lys Ser Thr Tyr Cys Ala Thr Met Val Gln His Cys
              15                  20                  25

 gaa gcc ctc aac cgg tct gtc caa gtt gta aac ctg gat cca gca gca      148
 Glu Ala Leu Asn Arg Ser Val Gln Val Val Asn Leu Asp Pro Ala Ala
          30                  35                  40

 gaa cac ttc aac tac tcc gtg atg gct gac atc cgg gaa ctg atc gag      196
 Glu His Phe Asn Tyr Ser Val Met Ala Asp Ile Arg Glu Leu Ile Glu
      45                  50                  55

 gtg gat gat gta atg gag gat gat tct ctg cga ttc ggt ccc aac gga      244
 Val Asp Asp Val Met Glu Asp Asp Ser Leu Arg Phe Gly Pro Asn Gly
  60                  65                  70                  75

 gga ttg gta ttt tgc atg gag tac ttt gcc aat aat ttt gac tgg ctg      292
 Gly Leu Val Phe Cys Met Glu Tyr Phe Ala Asn Asn Phe Asp Trp Leu
                  80                  85                  90

 gag aac tgt ctt ggc cat gta gag gac gac tat atc ctt ttt gat tgt      340
 Glu Asn Cys Leu Gly His Val Glu Asp Asp Tyr Ile Leu Phe Asp Cys
              95                 100                 105

 cca ggt cag att gag ttg tac act cac ctg cct gtg atg aaa cag ctg      388
 Pro Gly Gln Ile Glu Leu Tyr Thr His Leu Pro Val Met Lys Gln Leu
         110                 115                 120

 gtc cag cag ctc gag cag tgg gag ttc cga gtc tgt gga gtt ttt ctt      436
 Val Gln Gln Leu Glu Gln Trp Glu Phe Arg Val Cys Gly Val Phe Leu
     125                 130                 135

 gtt gat tct cag ttc atg gtg gag tca ttc aag ttt att tct ggc atc      484
 Val Asp Ser Gln Phe Met Val Glu Ser Phe Lys Phe Ile Ser Gly Ile
 140                 145                 150                 155

 ttg gca gcc ctg agt gcc atg atc tct cta gaa att ccg caa gtc aac      532
 Leu Ala Ala Leu Ser Ala Met Ile Ser Leu Glu Ile Pro Gln Val Asn
                 160                 165                 170

 atc atg aca aaa atg gat ctg ctg agt aaa aaa gca aaa aag gaa att      580
 Ile Met Thr Lys Met Asp Leu Leu Ser Lys Lys Ala Lys Lys Glu Ile
             175                 180                 185

 gag aaa ttt tta gat cca gac atg tat tct tta tta gaa gat tct aca      628
 Glu Lys Phe Leu Asp Pro Asp Met Tyr Ser Leu Leu Glu Asp Ser Thr
         190                 195                 200

 agt gac tta aga agc aaa aaa ttc aag aaa ctg act aaa gct ata tgt      676
 Ser Asp Leu Arg Ser Lys Lys Phe Lys Lys Leu Thr Lys Ala Ile Cys
     205                 210                 215

 gga ctg att gat gac tac agc atg gtt cga ttt tta cct tac gat cag      724
 Gly Leu Ile Asp Asp Tyr Ser Met Val Arg Phe Leu Pro Tyr Asp Gln
 220                 225                 230                 235

 tca gat gaa gaa agc atg aac att gta ttg cag cat att gat ttt gcc      772
 Ser Asp Glu Glu Ser Met Asn Ile Val Leu Gln His Ile Asp Phe Ala
                 240                 245                 250

 att caa tat gga gaa gac cta gaa ttt aaa gaa cca aag gaa cgt gaa      820
 Ile Gln Tyr Gly Glu Asp Leu Glu Phe Lys Glu Pro Lys Glu Arg Glu
             255                 260                 265

 gat gag tct tcc tct atg ttt gac gaa tat ttt caa gaa tgc cag gat      868
 Asp Glu Ser Ser Ser Met Phe Asp Glu Tyr Phe Gln Glu Cys Gln Asp
         270                 275                 280

 gaa tgaa gagtttacta aaagtaacca tctaaagagc ttgtggccaa accagcagaa      925
 Glu 


 cattcttctc ttcaaaggat gcaatagtag aaagctactt attttaatga aaaaaagtaa    985

 aacttcgttc tttatcagca aaaaaaaaa                                     1014




      <210> 80
      <211> 1055
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (139)..(795)

      <400> 80
 catacaacaa gaggaagagt ctgcacgcag aagcaccacc ttctagggat aaataaaggg     60

 tcaagctaag gaagggcaga acaaacttca gacactcact tctttgcctc aacttcagcc    120

 tgctctcaca acctcact  atg tct tgc ccc aac tac tgc tcg gga aac tcc     171
                      Met Ser Cys Pro Asn Tyr Cys Ser Gly Asn Ser
                        1               5                  10

 aac tca gga tct ctc aga acc tcc cgc cat att cct ctc acc tcc atc      219
 Asn Ser Gly Ser Leu Arg Thr Ser Arg His Ile Pro Leu Thr Ser Ile
              15                  20                  25

 gac ctc tgc cct acc agc gtg agc tgt gga gat gtc ctc tac tta ccc      267
 Asp Leu Cys Pro Thr Ser Val Ser Cys Gly Asp Val Leu Tyr Leu Pro
          30                  35                  40

 act agc tct caa gac cat acc tgg gtc aca gac aac tgc caa gag acc      315
 Thr Ser Ser Gln Asp His Thr Trp Val Thr Asp Asn Cys Gln Glu Thr
      45                  50                  55

 tgc ggt gaa cca acc agc tgc cag ccg gtc cac tgt gag acc ggc aat      363
 Cys Gly Glu Pro Thr Ser Cys Gln Pro Val His Cys Glu Thr Gly Asn
  60                  65                  70                  75

 ctt gaa acc tct tgc ggt tct tcc act gct tac tac gtg ccc agg cct      411
 Leu Glu Thr Ser Cys Gly Ser Ser Thr Ala Tyr Tyr Val Pro Arg Pro
                  80                  85                  90

 tgc caa gga agc agt ttt ctt cct gct tct ttc ttc tcc agt tcc tgc      459
 Cys Gln Gly Ser Ser Phe Leu Pro Ala Ser Phe Phe Ser Ser Ser Cys
              95                 100                 105

 ctt cca gta tcc tgt aga cca cag agg tat gtg tcc agc ggc tgt cgt      507
 Leu Pro Val Ser Cys Arg Pro Gln Arg Tyr Val Ser Ser Gly Cys Arg
         110                 115                 120

 cca ctg agg ccg ctg ctc aat agt tac cag ccc ata ggg aga ctg tgt      555
 Pro Leu Arg Pro Leu Leu Asn Ser Tyr Gln Pro Ile Gly Arg Leu Cys
     125                 130                 135

 gcc caa tgc cta tcg ccc cca att ctc ctt gtc caa gag ttg cca gcc      603
 Ala Gln Cys Leu Ser Pro Pro Ile Leu Leu Val Gln Glu Leu Pro Ala
 140                 145                 150                 155

 cca aaa cct cct cac ttc tgg atg cca acc ctc gag ttg ctt ggc cta      651
 Pro Lys Pro Pro His Phe Trp Met Pro Thr Leu Glu Leu Leu Gly Leu
                 160                 165                 170

 tcg tcc tca aag tct tca cgt tgt gtc cag cag cct cag acc tct ggg      699
 Ser Ser Ser Lys Ser Ser Arg Cys Val Gln Gln Pro Gln Thr Ser Gly
             175                 180                 185

 gac tct gtt cag tgg ttg cca acc tct gac cca tgt gtt cag cac gtg      747
 Asp Ser Val Gln Trp Leu Pro Thr Ser Asp Pro Cys Val Gln His Val
         190                 195                 200

 tcg tcc atc ttg ctc tgg act gtg aaa cca gca gct tct ttg ttc cag      795
 Ser Ser Ile Leu Leu Trp Thr Val Lys Pro Ala Ala Ser Leu Phe Gln 
     205                 210                 215

 tgaataatca ctctgagcat ccacaacaaa aattcaaact ccatggactt ttgcttcttt    855

 gctagtagca actgatgttt cttagtttta ctgtgcctga tctaatgcaa gctgcttctc    915

 tcgcatgttt tatcttgttt tcatctttcc ttgacatcaa aaaaattagt ttacaatgct    975

 attcaatgtt gctctggtct gggaagaatg tatttgtttt gcactataat aaatgcgatt   1035

 aagtccaaat aggtacccga                                               1055




      <210> 81
      <211> 2390
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (140)..(2041)

      <400> 81
 cggacgcgtg ggcggacgcg tgggcgcagc cgcctccagg gcaatttgca tatttctcca     60

 aagaaccatc cagaacctga gcagcctgtc ttcagacaga gagaggccca cggctgtttc    120

 ttgaaatctg gcgctggga atg gcc atg tgg aac agg cca tgc cag agg ctg     172
                      Met Ala Met Trp Asn Arg Pro Cys Gln Arg Leu
                        1               5                  10

 cct cag cag cct ctg gta gct gag ccc act gca gag ggg gag cca cac      220
 Pro Gln Gln Pro Leu Val Ala Glu Pro Thr Ala Glu Gly Glu Pro His
              15                  20                  25

 ctg ccc acg ggc cgg gag ctg act gag gcc aac cgc ttc gcc tat gct      268
 Leu Pro Thr Gly Arg Glu Leu Thr Glu Ala Asn Arg Phe Ala Tyr Ala
          30                  35                  40

 gcc ctc tgt ggc atc tcc ctg tcc cag tta ttt cct gaa ccc gaa cac      316
 Ala Leu Cys Gly Ile Ser Leu Ser Gln Leu Phe Pro Glu Pro Glu His
      45                  50                  55

 agc tcc ttc tgc aca gag ttc atg gca ggc ctg gtg cag tgg ctg gag      364
 Ser Ser Phe Cys Thr Glu Phe Met Ala Gly Leu Val Gln Trp Leu Glu
  60                  65                  70                  75

 ttg tct gaa gct gtc ttg cca acc atg act gct ttt gcg agc ggc ctg      412
 Leu Ser Glu Ala Val Leu Pro Thr Met Thr Ala Phe Ala Ser Gly Leu
                  80                  85                  90

 gga ggt gaa gga gca gat gtg ttt gtt caa att tta ctg aag gac ccc      460
 Gly Gly Glu Gly Ala Asp Val Phe Val Gln Ile Leu Leu Lys Asp Pro
              95                 100                 105

 atc ttg aag gac gac ccg acg gtg atc act cag gac ctt ctg agc ttc      508
 Ile Leu Lys Asp Asp Pro Thr Val Ile Thr Gln Asp Leu Leu Ser Phe
         110                 115                 120

 tca ctc aag gat ggg cac tat gac gcc cgg gcc aga gtc ctc gtt tgc      556
 Ser Leu Lys Asp Gly His Tyr Asp Ala Arg Ala Arg Val Leu Val Cys
     125                 130                 135

 cac atg acc tcc ctg ctc caa gtg ccc ttg gag gag ctg gat gtc ctt      604
 His Met Thr Ser Leu Leu Gln Val Pro Leu Glu Glu Leu Asp Val Leu
 140                 145                 150                 155

 gaa gag atg ttc ctg gag agc ctg aag gaa atc aaa gaa gag gaa tct      652
 Glu Glu Met Phe Leu Glu Ser Leu Lys Glu Ile Lys Glu Glu Glu Ser
                 160                 165                 170

 gaa atg gcc gag gca tcc cga aag aag aaa gaa aac cgg agg aaa tgg      700
 Glu Met Ala Glu Ala Ser Arg Lys Lys Lys Glu Asn Arg Arg Lys Trp
             175                 180                 185

 aag cgt tat ctc ctg ata ggc ctg gcg act gtc gga ggc gga acg gtg      748
 Lys Arg Tyr Leu Leu Ile Gly Leu Ala Thr Val Gly Gly Gly Thr Val
         190                 195                 200

 atc ggt gtg act gga ggt cta gct gca ccc ctt gtt gcc gct gga gca      796
 Ile Gly Val Thr Gly Gly Leu Ala Ala Pro Leu Val Ala Ala Gly Ala
     205                 210                 215

 gcg acg att att ggc agc gcc ggg gca gcg gct ctg ggc tca gca gcc      844
 Ala Thr Ile Ile Gly Ser Ala Gly Ala Ala Ala Leu Gly Ser Ala Ala
 220                 225                 230                 235

 ggc ata gcc atc atg acc tcg ctg ttt ggt gca gct gga gct ggc ctg      892
 Gly Ile Ala Ile Met Thr Ser Leu Phe Gly Ala Ala Gly Ala Gly Leu
                 240                 245                 250

 aca gga tac aag atg aag aag cga gtg gga gcc att gaa gag ttc acg      940
 Thr Gly Tyr Lys Met Lys Lys Arg Val Gly Ala Ile Glu Glu Phe Thr
             255                 260                 265

 ttt ctg cct ctg acg gag ggc agg cag ctg cac atc acc atc gcc gtc      988
 Phe Leu Pro Leu Thr Glu Gly Arg Gln Leu His Ile Thr Ile Ala Val
         270                 275                 280

 acg ggg tgg ctc gct tct ggc aaa tac cgc acc ttc agt gcc ccg tgg     1036
 Thr Gly Trp Leu Ala Ser Gly Lys Tyr Arg Thr Phe Ser Ala Pro Trp
     285                 290                 295

 gct gcc ctg gcc cac agc cgt gag cag tac tgc ctg gcc tgg gaa gcc     1084
 Ala Ala Leu Ala His Ser Arg Glu Gln Tyr Cys Leu Ala Trp Glu Ala
 300                 305                 310                 315

 aag tac ctg atg gag ctc ggc aat gcc ctg gag acc atc ctc agt ggt     1132
 Lys Tyr Leu Met Glu Leu Gly Asn Ala Leu Glu Thr Ile Leu Ser Gly
                 320                 325                 330

 ctc gcc aac atg gtg gcc cag gag gcc cta aag tac aca gtg ttg tct     1180
 Leu Ala Asn Met Val Ala Gln Glu Ala Leu Lys Tyr Thr Val Leu Ser
             335                 340                 345

 ggc att gtg gct gcc ctg acc tgg cca gcc tca ctc ctc agt gtc gcc     1228
 Gly Ile Val Ala Ala Leu Thr Trp Pro Ala Ser Leu Leu Ser Val Ala
         350                 355                 360

 aat gtc atc gac aac ccc tgg ggg gtg tgt ctc cat cga tca gca gag     1276
 Asn Val Ile Asp Asn Pro Trp Gly Val Cys Leu His Arg Ser Ala Glu
     365                 370                 375

 gtt ggc aag cac ctg gcc cac atc ctg ctc tcc cgg cag cag ggg cga     1324
 Val Gly Lys His Leu Ala His Ile Leu Leu Ser Arg Gln Gln Gly Arg
 380                 385                 390                 395

 cga cct gtc acc ttg att ggc ttc agc ctg gga gcc aga gtc atc tac     1372
 Arg Pro Val Thr Leu Ile Gly Phe Ser Leu Gly Ala Arg Val Ile Tyr
                 400                 405                 410

 ttc tgt ctg cag gag atg gct caa gag aaa gat tgc caa gga atc atc     1420
 Phe Cys Leu Gln Glu Met Ala Gln Glu Lys Asp Cys Gln Gly Ile Ile
             415                 420                 425

 gag gac gtc atc ctg ctg ggt gcg cct gtg gag gga gaa gcc aag cat     1468
 Glu Asp Val Ile Leu Leu Gly Ala Pro Val Glu Gly Glu Ala Lys His
         430                 435                 440

 tgg gag cct ttc cgg aag gtg gtg tcc ggg agg atc atc aac ggc tac     1516
 Trp Glu Pro Phe Arg Lys Val Val Ser Gly Arg Ile Ile Asn Gly Tyr
     445                 450                 455

 tgc agg gga gac tgg ctg ctg agt ttc gtg tac cgc aca tcc tcg gtg     1564
 Cys Arg Gly Asp Trp Leu Leu Ser Phe Val Tyr Arg Thr Ser Ser Val
 460                 465                 470                 475

 cag ctc cac gtc gcc ggc cta cag ccc gtg ctg ctg cag gac agg agg     1612
 Gln Leu His Val Ala Gly Leu Gln Pro Val Leu Leu Gln Asp Arg Arg
                 480                 485                 490

 gtg gag aac gtg gac ctg acc tct gtg gtc agc ggc cac ctg gac tat     1660
 Val Glu Asn Val Asp Leu Thr Ser Val Val Ser Gly His Leu Asp Tyr
             495                 500                 505

 gcc aag cag atg gat gcc atc ctg aag gcc gtg ggc atc cgc acc aag     1708
 Ala Lys Gln Met Asp Ala Ile Leu Lys Ala Val Gly Ile Arg Thr Lys
         510                 515                 520

 cca ggc tgg gac gag aag ggg ctc ttg ctg gcc cca ggc tgc ctg ccc     1756
 Pro Gly Trp Asp Glu Lys Gly Leu Leu Leu Ala Pro Gly Cys Leu Pro
     525                 530                 535

 tcc gag gag cct cgc cag gca gca gct gcc gcc tca tca ggc gag acc     1804
 Ser Glu Glu Pro Arg Gln Ala Ala Ala Ala Ala Ser Ser Gly Glu Thr
 540                 545                 550                 555

 ccc cac cag gtt ggg caa acc cag ggt ccc ata tcc gga gac acc tcc     1852
 Pro His Gln Val Gly Gln Thr Gln Gly Pro Ile Ser Gly Asp Thr Ser
                 560                 565                 570

 aaa ttg gcc atg tcc aca gac ccc agc caa gcc cag gtg cca gta ggg     1900
 Lys Leu Ala Met Ser Thr Asp Pro Ser Gln Ala Gln Val Pro Val Gly
             575                 580                 585

 ctg gac cag tct gaa ggg gcc tcc ctt cct gct gct gcc agc cct gaa     1948
 Leu Asp Gln Ser Glu Gly Ala Ser Leu Pro Ala Ala Ala Ser Pro Glu
         590                 595                 600

 agg ccc ccc atc tgc agc cat ggc atg gac ccc aac cca ctg ggc tgc     1996
 Arg Pro Pro Ile Cys Ser His Gly Met Asp Pro Asn Pro Leu Gly Cys
     605                 610                 615

 ccc gat tgt gcc tgc aag acc cag ggc ccc agc acg ggg ctg gac tga     2044
 Pro Asp Cys Ala Cys Lys Thr Gln Gly Pro Ser Thr Gly Leu Asp 
 620                 625                 630

 ccacagcagg ggacctgagc cgtcttcccc agtctccata tgcagctctc tcttataccc   2104

 tcgggttcct cccaggagct ctggaggtac aggatttcca caggcctctt tcctaaatgg   2164

 aaggaattgg aactgaaagg gaaaggaaat ggaaggaagg ggaatttgga ggagagaaca   2224

 cgcccaccct tgggaagctg cctgtcccca gaggagcccc accagggagc agctgccccc   2284

 tcatcagaga cctgcagagt caaccaagca caggttagag tcccaggacc ggaaaccaac   2344

 tgtgggcttt ctgtacttct catagctttg gagtctggct gtccat                  2390




      <210> 82
      <211> 902
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (12)..(863)

      <400> 82
 gggaagggag a atg gcg gcg ccc ggg ctg cgg ctg gga gcg gga aga ctc      50
              Met Ala Ala Pro Gly Leu Arg Leu Gly Ala Gly Arg Leu
                1               5                  10

 ttt gaa atg cct gcg gtg cta gag cga ctg agc cgc tat aat agc acg       98
 Phe Glu Met Pro Ala Val Leu Glu Arg Leu Ser Arg Tyr Asn Ser Thr
      15                  20                  25

 tcc caa gct ttt gct gag gtg ctg cgg ctg ccg aag cag cag ctg agg      146
 Ser Gln Ala Phe Ala Glu Val Leu Arg Leu Pro Lys Gln Gln Leu Arg
  30                  35                  40                  45

 aag ctg ctg tac ccg ctg cag gaa gta gag cgg ttc ctc gcc ccc tac      194
 Lys Leu Leu Tyr Pro Leu Gln Glu Val Glu Arg Phe Leu Ala Pro Tyr
                  50                  55                  60

 ggg agg caa gac ctt cac ctg cgt atc ttt gac cca agc ccg gag gac      242
 Gly Arg Gln Asp Leu His Leu Arg Ile Phe Asp Pro Ser Pro Glu Asp
              65                  70                  75

 ata gcc agg gcg gac aac atc ttc acg gcc act gaa cgg aac cgc atc      290
 Ile Ala Arg Ala Asp Asn Ile Phe Thr Ala Thr Glu Arg Asn Arg Ile
          80                  85                  90

 gac tac gtc agc tcc gcc gtc cgt atc gac cac gcc ccg gac ctt ccg      338
 Asp Tyr Val Ser Ser Ala Val Arg Ile Asp His Ala Pro Asp Leu Pro
      95                 100                 105

 cgg cca gag gtg tgt ttt ata ggc aga agc aat gtt gga aaa tca tct      386
 Arg Pro Glu Val Cys Phe Ile Gly Arg Ser Asn Val Gly Lys Ser Ser
 110                 115                 120                 125

 cta atc aag gct tta ttt tca ctg gcc cct gag gtt gaa gtc aga gtc      434
 Leu Ile Lys Ala Leu Phe Ser Leu Ala Pro Glu Val Glu Val Arg Val
                 130                 135                 140

 tcc aaa aaa cca gga cac aca aag aaa atg aat ttt ttc aaa gtt gga      482
 Ser Lys Lys Pro Gly His Thr Lys Lys Met Asn Phe Phe Lys Val Gly
             145                 150                 155

 aaa cat ttt aca gtg gtg gac atg cca ggt tat ggc ttt aga gca cct      530
 Lys His Phe Thr Val Val Asp Met Pro Gly Tyr Gly Phe Arg Ala Pro
         160                 165                 170

 gaa gat ttt gtt gac atg gta gag acc tat cta aaa gaa cga agg aac      578
 Glu Asp Phe Val Asp Met Val Glu Thr Tyr Leu Lys Glu Arg Arg Asn
     175                 180                 185

 ttg aag aga aca ttt tta tta gtg gat agc gtt gtt gga att caa aaa      626
 Leu Lys Arg Thr Phe Leu Leu Val Asp Ser Val Val Gly Ile Gln Lys
 190                 195                 200                 205

 aca gac aat att gcc ata gaa atg tgt gaa gaa ttt gca tta cct tat      674
 Thr Asp Asn Ile Ala Ile Glu Met Cys Glu Glu Phe Ala Leu Pro Tyr
                 210                 215                 220

 gtg att gta tta aca aaa att gac aaa tct tcc aag gga cat ctt tta      722
 Val Ile Val Leu Thr Lys Ile Asp Lys Ser Ser Lys Gly His Leu Leu
             225                 230                 235

 aaa caa gtg ctt cag atc cag aaa ttt gtt aac atg aaa act caa gga      770
 Lys Gln Val Leu Gln Ile Gln Lys Phe Val Asn Met Lys Thr Gln Gly
         240                 245                 250

 tgt ttt cct cag ttg ttt cct gta agt gct gtg acc ttt tct gga atc      818
 Cys Phe Pro Gln Leu Phe Pro Val Ser Ala Val Thr Phe Ser Gly Ile
     255                 260                 265

 cac ctg ttg aga tgc ttt ata gcc agt gta aca gga agt ctt gac taa      866
 His Leu Leu Arg Cys Phe Ile Ala Ser Val Thr Gly Ser Leu Asp 
 270                 275                 280

 tggttcccgg tttagctgaa gattcaaaaa aaaaaa                              902




      <210> 83
      <211> 1416
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (547)..(1299)

      <400> 83
 gatatccttc agaacattag aattctcgtg cggtgttacg ttgaagtgga ccggtttagt     60

 cagcaatggc cagacccacc taaatgaaca cagacccata tggtggtctg tccttttaca    120

 gccagtagtg ctcgccgcag tcgagcgaca gggcgaagcc ctcgagtgag cgaggaagcc    180

 ccagggaaca gcacttatat attctgcttc cacacgatgc ctgaaaaaac ttcccctgtg    240

 gggttatcca cttatccacg gggatatttt tataattatt ttttttatag tttttagatc    300

 ttctttttta gagcgccttg taggccttta tccatgctgg ttctagagaa ggtgttgtga    360

 caaattgccc tttcagtgtg acaaatcacc ctcaaatgac agtcctgtct gtgacaaatt    420

 gcccttaacc ctgtgacaaa ttgccctcag aagaagctgt tttttcacaa agttatccct    480

 gcttattgac tcttttttat ttagtgtgac aatctaaaaa cttgtcacac ttcacatgga    540

 tctgtc   atg gcg gaa aca gcg gtt atc aat cac aag aaa cgt aaa aat     588
          Met Ala Glu Thr Ala Val Ile Asn His Lys Lys Arg Lys Asn
            1               5                  10

 agc ccg cga atc gtc cag tca aac gac ctc act gag gcg gca tat agt      636
 Ser Pro Arg Ile Val Gln Ser Asn Asp Leu Thr Glu Ala Ala Tyr Ser
  15                  20                  25                  30

 ctc tcc cgg gat caa aaa cgt atg ctg tat ctg ttc gtt gac cag atc      684
 Leu Ser Arg Asp Gln Lys Arg Met Leu Tyr Leu Phe Val Asp Gln Ile
                  35                  40                  45

 aga aaa tct gat ggc acc cta cag gaa cat gac ggt atc tgc gag atc      732
 Arg Lys Ser Asp Gly Thr Leu Gln Glu His Asp Gly Ile Cys Glu Ile
              50                  55                  60

 cat gtt gct aaa tat gct gaa ata ttc gga ttg acc tct gcg gaa gcc      780
 His Val Ala Lys Tyr Ala Glu Ile Phe Gly Leu Thr Ser Ala Glu Ala
          65                  70                  75

 agt aag gat ata cgg cag gca ttg aag agt ttc gcg ggg aag gaa gtg      828
 Ser Lys Asp Ile Arg Gln Ala Leu Lys Ser Phe Ala Gly Lys Glu Val
      80                  85                  90

 gtt ttt tat cgc cct gaa gag gat gcc ggc gat gaa aaa ggc tat gaa      876
 Val Phe Tyr Arg Pro Glu Glu Asp Ala Gly Asp Glu Lys Gly Tyr Glu
  95                 100                 105                 110

 tct ttt cct tgg ttt atc aaa cgt gcg cac agt cca tcc aga ggg ctt      924
 Ser Phe Pro Trp Phe Ile Lys Arg Ala His Ser Pro Ser Arg Gly Leu
                 115                 120                 125

 tac agt gta cat atc aac cca tat ctc att ccc ttc ttt atc ggg tta      972
 Tyr Ser Val His Ile Asn Pro Tyr Leu Ile Pro Phe Phe Ile Gly Leu
             130                 135                 140

 cag aac cgg ttt acg cag ttt cgg ctt agt gaa aca aaa gaa atc acc     1020
 Gln Asn Arg Phe Thr Gln Phe Arg Leu Ser Glu Thr Lys Glu Ile Thr
         145                 150                 155

 aat ccg tat gcc atg cgt tta tac gaa tcc ctg tgt cag tat cgt aag     1068
 Asn Pro Tyr Ala Met Arg Leu Tyr Glu Ser Leu Cys Gln Tyr Arg Lys
     160                 165                 170

 ccg gat ggc tca ggc atc gtc tct ctg aaa atc gac tgg atc ata gag     1116
 Pro Asp Gly Ser Gly Ile Val Ser Leu Lys Ile Asp Trp Ile Ile Glu
 175                 180                 185                 190

 cgt tac cag ctg cct caa agt tac cag cgt atg cct gac ttc cgc cgc     1164
 Arg Tyr Gln Leu Pro Gln Ser Tyr Gln Arg Met Pro Asp Phe Arg Arg
                 195                 200                 205

 cgc ttc ctg cag gtc tgt gtt aat gag atc aac agc aga act cca atg     1212
 Arg Phe Leu Gln Val Cys Val Asn Glu Ile Asn Ser Arg Thr Pro Met
             210                 215                 220

 cgc ctc tca tac att gag aaa aag aaa ggc cgc cag acg act cat aac     1260
 Arg Leu Ser Tyr Ile Glu Lys Lys Lys Gly Arg Gln Thr Thr His Asn
         225                 230                 235

 gca ttt tcc ttc cgc gat atc act tcc atg acg aca gga tagtctgagg      1309
 Ala Phe Ser Phe Arg Asp Ile Thr Ser Met Thr Thr Gly 
     240                 245                 250

 gtatctgtca cagattgaga ggggggttcg tccatttggt ctggacctac ggaggggaat   1369

 tgggcccaag tttggtggtt ccttcacccc gggggatttt tcaaact                 1416




      <210> 84
      <211> 1642
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (773)..(1525)

      <400> 84
 gccacttcat ggggcggcgt tgggaggcgg cgagaatggg gcgcaggggc gtgaagtggg     60

 tacgcagggt ggtcccgctc ccgacgtgtt aaagcgcggc ccagggccaa gttgcaggct    120

 cggggcgcct ttagaggatc cgccttatta ttcccagagc ctgggaagcg tttatagaag    180

 tagtgttctg tcattatgcc tgcaaccggt aacaaaaacg atttgaatat gcttcaggga    240

 ccaatagaaa tcttggtgcg gtgttacgtt gaagtggagc ggattatgtc agcaatggac    300

 agaacaacgt aatgaacaca gacccatgat gtggtctgtc cttttacagc cagtagtgct    360

 cgccgcagtc gagcgacagg gcgaagccct cgagtgagcg aggaagcacc agggaacagc    420

 acttatatat tctgcttaca cacgatgcct gaaaaaactt cccttggggt tatccactta    480

 tccacgggga tatttttata attatttttt ttatagtttt tagatcttct tttttagagc    540

 gccttgtagg cctttatcca tgctggttct agagaaggtg ttgtgacaaa ttgccctttc    600

 agtgtgacaa atcaccctca aatgacagtc ctgtctgtga caaattgccc ttaaccctgt    660

 gacaaattgc cctcagaaga agctgttttt tcacaaagtt atccctgctt attgactctt    720

 ttttatttag tgtgacaatc taaaaacttg tcacacttca catggatctg tc    atg     775
                                                              Met
                                                                1

 gcg gaa aca gcg gtt atc aat cac aag aaa cgt aaa aat agc ccg cga      823
 Ala Glu Thr Ala Val Ile Asn His Lys Lys Arg Lys Asn Ser Pro Arg
               5                  10                  15

 atc gtc cag tca aac gac ctc act gag gcg gca tat agt ctc tcc cgg      871
 Ile Val Gln Ser Asn Asp Leu Thr Glu Ala Ala Tyr Ser Leu Ser Arg
          20                  25                  30

 gat caa aaa cgt atg ctg tat ctg ttc gtt gac cag atc aga aaa tct      919
 Asp Gln Lys Arg Met Leu Tyr Leu Phe Val Asp Gln Ile Arg Lys Ser
      35                  40                  45

 gat ggc acc cta cag gaa cat gac ggt atc tgc gag atc cat gtt gct      967
 Asp Gly Thr Leu Gln Glu His Asp Gly Ile Cys Glu Ile His Val Ala
  50                  55                  60                  65

 aaa tat gct gaa ata ttc gga ttg acc tct gcg gaa gcc agt aag gat     1015
 Lys Tyr Ala Glu Ile Phe Gly Leu Thr Ser Ala Glu Ala Ser Lys Asp
                  70                  75                  80

 ata cgg cag gca ttg aag agt ttc gcg ggg aag gaa gtg gtt ttt tat     1063
 Ile Arg Gln Ala Leu Lys Ser Phe Ala Gly Lys Glu Val Val Phe Tyr
              85                  90                  95

 cgc cct gaa gag gat gcc ggc gat gaa aaa ggc tat gaa tct ttt cct     1111
 Arg Pro Glu Glu Asp Ala Gly Asp Glu Lys Gly Tyr Glu Ser Phe Pro
         100                 105                 110

 tgg ttt atc aaa cgt gcg cac agt cca tcc aga ggg ctt tac agt gta     1159
 Trp Phe Ile Lys Arg Ala His Ser Pro Ser Arg Gly Leu Tyr Ser Val
     115                 120                 125

 cat atc aac cca tat ctc att ccc ttc ttt atc ggg tta cag aac cgg     1207
 His Ile Asn Pro Tyr Leu Ile Pro Phe Phe Ile Gly Leu Gln Asn Arg
 130                 135                 140                 145

 ttt acg cag ttt cgg ctt agt gaa aca aaa gaa atc acc aat ccg tat     1255
 Phe Thr Gln Phe Arg Leu Ser Glu Thr Lys Glu Ile Thr Asn Pro Tyr
                 150                 155                 160

 gcc atg cgt tta tac gaa tcc ctg tgt cag tat cgt aag ccg gat ggc     1303
 Ala Met Arg Leu Tyr Glu Ser Leu Cys Gln Tyr Arg Lys Pro Asp Gly
             165                 170                 175

 tca ggc atc gtc tct ctg aaa atc gac tgg atc ata gag cgt tac cag     1351
 Ser Gly Ile Val Ser Leu Lys Ile Asp Trp Ile Ile Glu Arg Tyr Gln
         180                 185                 190

 ctg cct caa agt tac cag cgt atg cct gac ttc cgc cgc cgc ttc ctg     1399
 Leu Pro Gln Ser Tyr Gln Arg Met Pro Asp Phe Arg Arg Arg Phe Leu
     195                 200                 205

 cag gtc tgt gtt aat gag atc aac agc aga act cca atg cgc ctc tca     1447
 Gln Val Cys Val Asn Glu Ile Asn Ser Arg Thr Pro Met Arg Leu Ser
 210                 215                 220                 225

 tac att gag aaa aag aaa ggc cgc cag acg act cat atc gta ttt tcc     1495
 Tyr Ile Glu Lys Lys Lys Gly Arg Gln Thr Thr His Ile Val Phe Ser
                 230                 235                 240

 ttc cgc gat atc act tcc atg acg aca gga t agtctgaggg tatctgtcac     1546
 Phe Arg Asp Ile Thr Ser Met Thr Thr Gly 
             245                 250

 agattgagag gggggttcgt ccatttggtc tggacctacg gaggggaatt gggcccaagt   1606

 ttggtggttc cttcaccccg ggggattttt caaact                             1642




      <210> 85
      <211> 3363
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (187)..(2814)

      <400> 85
 gctgggtggt cgggcgcttg gtccggtagt tgttcggtgg accagcggcc cgtcgctcgc     60

 ttctgggctc tcatgtttga aggtgggagg gacacgggag cggcccgcac acctgagccg    120

 cccggagagg agcctcggcc ccgtacccag taagaagagg aggaggccag gcaggcaaaa    180

 ggagtc   atg gct tct gat gct agt cat gcg ctg gaa gct gcc ctg gag     228
          Met Ala Ser Asp Ala Ser His Ala Leu Glu Ala Ala Leu Glu
            1               5                  10

 caa atg gac ggg atc att gca ggc act aaa aca ggt gca gat ctt agt      276
 Gln Met Asp Gly Ile Ile Ala Gly Thr Lys Thr Gly Ala Asp Leu Ser
  15                  20                  25                  30

 gat ggt act tgt gag cct gga ctg gct tcc ccg gcc tcc tac atg aac      324
 Asp Gly Thr Cys Glu Pro Gly Leu Ala Ser Pro Ala Ser Tyr Met Asn
                  35                  40                  45

 ccc ttc ccg gtg ctc cat ctc atc gag gac ttg agg ctg gcc ttg gag      372
 Pro Phe Pro Val Leu His Leu Ile Glu Asp Leu Arg Leu Ala Leu Glu
              50                  55                  60

 atg ctg gag ctt cct cag gag aga gca gcc ctc ctg agc cag atc cct      420
 Met Leu Glu Leu Pro Gln Glu Arg Ala Ala Leu Leu Ser Gln Ile Pro
          65                  70                  75

 ggc cca aca gct gcc tac ata aag gaa tgg ttt gaa gag agc ttg tcc      468
 Gly Pro Thr Ala Ala Tyr Ile Lys Glu Trp Phe Glu Glu Ser Leu Ser
      80                  85                  90

 cag gta aac cac cac agt gct gct agt aat gaa acc tac cag gaa cgc      516
 Gln Val Asn His His Ser Ala Ala Ser Asn Glu Thr Tyr Gln Glu Arg
  95                 100                 105                 110

 ttg gca cgt cta gaa ggg gat aag gag tcc ctc ata ttg cag gtg agt      564
 Leu Ala Arg Leu Glu Gly Asp Lys Glu Ser Leu Ile Leu Gln Val Ser
                 115                 120                 125

 gtc ctc aca gac caa gta gaa gcc cag gga gaa aag att cga gac ctg      612
 Val Leu Thr Asp Gln Val Glu Ala Gln Gly Glu Lys Ile Arg Asp Leu
             130                 135                 140

 gaa gtg tgt ctg gaa gga cac cag gtg aaa ctc aat gct gct gaa gag      660
 Glu Val Cys Leu Glu Gly His Gln Val Lys Leu Asn Ala Ala Glu Glu
         145                 150                 155

 atg ctt caa cag gag ctg cta agc cgc aca tct ctt gag acc cag aag      708
 Met Leu Gln Gln Glu Leu Leu Ser Arg Thr Ser Leu Glu Thr Gln Lys
     160                 165                 170

 ctc gat ctg atg act gaa gtg tct gag ctg aag ctc aag ctg gtt ggc      756
 Leu Asp Leu Met Thr Glu Val Ser Glu Leu Lys Leu Lys Leu Val Gly
 175                 180                 185                 190

 atg gag aag gag cag aga gag cag gag gag aag cag aga aaa gca gag      804
 Met Glu Lys Glu Gln Arg Glu Gln Glu Glu Lys Gln Arg Lys Ala Glu
                 195                 200                 205

 gag tta ctg caa gag ctc agg cac ctc aaa atc aaa gtg gaa gag ttg      852
 Glu Leu Leu Gln Glu Leu Arg His Leu Lys Ile Lys Val Glu Glu Leu
             210                 215                 220

 gaa aat gaa agg aat cag tat gaa tgg aag cta aag gcc act aag gct      900
 Glu Asn Glu Arg Asn Gln Tyr Glu Trp Lys Leu Lys Ala Thr Lys Ala
         225                 230                 235

 gaa gtc gcc cag ctg caa gaa cag gtg gcc ctg aaa gat gca gaa att      948
 Glu Val Ala Gln Leu Gln Glu Gln Val Ala Leu Lys Asp Ala Glu Ile
     240                 245                 250

 gag cgt ctg cac agc cag ctc tcc cgg aca gca gct ctc cac agt gag      996
 Glu Arg Leu His Ser Gln Leu Ser Arg Thr Ala Ala Leu His Ser Glu
 255                 260                 265                 270

 agt cac aca gag aga gac caa gaa att caa cgt ctg aaa atg ggg atg     1044
 Ser His Thr Glu Arg Asp Gln Glu Ile Gln Arg Leu Lys Met Gly Met
                 275                 280                 285

 gaa act ttg ctg ctt gcc aat gaa gat aag gac cgt cgg ata gag gag     1092
 Glu Thr Leu Leu Leu Ala Asn Glu Asp Lys Asp Arg Arg Ile Glu Glu
             290                 295                 300

 ctt acg ggg ctg tta aac cag tac cgg aag gta aag gag att gtg atg     1140
 Leu Thr Gly Leu Leu Asn Gln Tyr Arg Lys Val Lys Glu Ile Val Met
         305                 310                 315

 gtc act caa ggg cct tcg gag aga act ctc tca atc aat gaa gaa gaa     1188
 Val Thr Gln Gly Pro Ser Glu Arg Thr Leu Ser Ile Asn Glu Glu Glu
     320                 325                 330

 ccg gag gga ggt ttc agc aag tgg aac gct aca aat aag gac cct gaa     1236
 Pro Glu Gly Gly Phe Ser Lys Trp Asn Ala Thr Asn Lys Asp Pro Glu
 335                 340                 345                 350

 gaa tta ttt aaa caa gag atg cct cca aga tgt agc tct cct aca gtg     1284
 Glu Leu Phe Lys Gln Glu Met Pro Pro Arg Cys Ser Ser Pro Thr Val
                 355                 360                 365

 ggg cca cct cca ttg cca cag aaa tca ctg gaa acc agg gct cag aaa     1332
 Gly Pro Pro Pro Leu Pro Gln Lys Ser Leu Glu Thr Arg Ala Gln Lys
             370                 375                 380

 aag ctc tct tgt agt cta gaa gac ttg aga agt gaa tct gtg gat aag     1380
 Lys Leu Ser Cys Ser Leu Glu Asp Leu Arg Ser Glu Ser Val Asp Lys
         385                 390                 395

 tgt atg gat ggg aac cag ccc ttc ccg gtg tta gaa ccc aag gac agc     1428
 Cys Met Asp Gly Asn Gln Pro Phe Pro Val Leu Glu Pro Lys Asp Ser
     400                 405                 410

 cct ttc ttg gcg gag cac aaa tat ccc act tta cct ggg aag ctt tca     1476
 Pro Phe Leu Ala Glu His Lys Tyr Pro Thr Leu Pro Gly Lys Leu Ser
 415                 420                 425                 430

 gga gcc acg ccc aat gga gag gct gcc aaa tct cct ccc acc atc tgc     1524
 Gly Ala Thr Pro Asn Gly Glu Ala Ala Lys Ser Pro Pro Thr Ile Cys
                 435                 440                 445

 cag cct gac gcc acg ggg agc agc ctg ctg agg ctg aga gac aca gaa     1572
 Gln Pro Asp Ala Thr Gly Ser Ser Leu Leu Arg Leu Arg Asp Thr Glu
             450                 455                 460

 agt ggc tgg gat gac act gct gtg gtc aat gac ctc tca tcc aca tca     1620
 Ser Gly Trp Asp Asp Thr Ala Val Val Asn Asp Leu Ser Ser Thr Ser
         465                 470                 475

 tcg ggc act gaa tca ggt cct cag tct cct ctg aca cca gat ggt aaa     1668
 Ser Gly Thr Glu Ser Gly Pro Gln Ser Pro Leu Thr Pro Asp Gly Lys
     480                 485                 490

 cgg aat ccc aaa ggc att aag aag ttc tgg gga aaa atc cga aga act     1716
 Arg Asn Pro Lys Gly Ile Lys Lys Phe Trp Gly Lys Ile Arg Arg Thr
 495                 500                 505                 510

 cag tca gga aat ttc tac act gac acg ctg ggg atg gca gag ttt cga     1764
 Gln Ser Gly Asn Phe Tyr Thr Asp Thr Leu Gly Met Ala Glu Phe Arg
                 515                 520                 525

 cga ggt ggg ctc cgg gca acc gca ggg cca aga ctc tct agg acc agg     1812
 Arg Gly Gly Leu Arg Ala Thr Ala Gly Pro Arg Leu Ser Arg Thr Arg
             530                 535                 540

 gac tcc aag gga cag aaa agt gac gcc aat gcc ccc ttt gcc cag tgg     1860
 Asp Ser Lys Gly Gln Lys Ser Asp Ala Asn Ala Pro Phe Ala Gln Trp
         545                 550                 555

 agc aca gag cgt gtg tgt gca tgg ctg gag gac ttt ggc ctg gct cag     1908
 Ser Thr Glu Arg Val Cys Ala Trp Leu Glu Asp Phe Gly Leu Ala Gln
     560                 565                 570

 tat gtg atc ttt gcc agg cag tgg gta tct tct ggc cac acc tta ttg     1956
 Tyr Val Ile Phe Ala Arg Gln Trp Val Ser Ser Gly His Thr Leu Leu
 575                 580                 585                 590

 aca gcc acc cct cag gac atg gaa aag gag cta gga att aag cac cca     2004
 Thr Ala Thr Pro Gln Asp Met Glu Lys Glu Leu Gly Ile Lys His Pro
                 595                 600                 605

 ctc cac agg aag aag ctt gtt tta gca gtg aaa gcc atc aac acc aaa     2052
 Leu His Arg Lys Lys Leu Val Leu Ala Val Lys Ala Ile Asn Thr Lys
             610                 615                 620

 cag gag gag aag tct gca ctg cta gac cac att tgg gtg aca agg tgg     2100
 Gln Glu Glu Lys Ser Ala Leu Leu Asp His Ile Trp Val Thr Arg Trp
         625                 630                 635

 ctt gat gat att ggc tta ccc cag tac aaa gac cag ttt cat gaa tct     2148
 Leu Asp Asp Ile Gly Leu Pro Gln Tyr Lys Asp Gln Phe His Glu Ser
     640                 645                 650

 aga gtt gac gga cga atg ctg caa tac cta act gtg aac gat tta ctc     2196
 Arg Val Asp Gly Arg Met Leu Gln Tyr Leu Thr Val Asn Asp Leu Leu
 655                 660                 665                 670

 ttc tta aaa gtc acc agc caa cta cat cat ctc agc atc aaa tgt gcc     2244
 Phe Leu Lys Val Thr Ser Gln Leu His His Leu Ser Ile Lys Cys Ala
                 675                 680                 685

 att cac gtg ctg cat gtc aac aag ttc aac ccc cac tgc ctg cac ctg     2292
 Ile His Val Leu His Val Asn Lys Phe Asn Pro His Cys Leu His Leu
             690                 695                 700

 cgg cca gct gat gag agt aac ctt tct cct tca gaa gtt gta cag tgg     2340
 Arg Pro Ala Asp Glu Ser Asn Leu Ser Pro Ser Glu Val Val Gln Trp
         705                 710                 715

 tcc aac cac agg gtg atg gag tgg tta cga tct gtg gac ctg gca gag     2388
 Ser Asn His Arg Val Met Glu Trp Leu Arg Ser Val Asp Leu Ala Glu
     720                 725                 730

 tat gca ccc aat ctt cga ggg agt gga gtc cat gga ggc ctc att atc     2436
 Tyr Ala Pro Asn Leu Arg Gly Ser Gly Val His Gly Gly Leu Ile Ile
 735                 740                 745                 750

 ctg gag cca cgc ttc act ggg gac acc ctg gct atg ctt ctc aac atc     2484
 Leu Glu Pro Arg Phe Thr Gly Asp Thr Leu Ala Met Leu Leu Asn Ile
                 755                 760                 765

 ccc cca caa aag acg ctc ctc agg cgc cac ctg acc acc aag ttc aat     2532
 Pro Pro Gln Lys Thr Leu Leu Arg Arg His Leu Thr Thr Lys Phe Asn
             770                 775                 780

 gcc ttg att ggt ccg gag gct gaa cag gag aag cga gag aaa atg gcc     2580
 Ala Leu Ile Gly Pro Glu Ala Glu Gln Glu Lys Arg Glu Lys Met Ala
         785                 790                 795

 tca cca gct tac aca cca ctg acc acc aca gcc aaa gtc cgg cca agg     2628
 Ser Pro Ala Tyr Thr Pro Leu Thr Thr Thr Ala Lys Val Arg Pro Arg
     800                 805                 810

 aaa cta gga ttt tca cac ttc gga aac ata aga aaa aag aag ttc gat     2676
 Lys Leu Gly Phe Ser His Phe Gly Asn Ile Arg Lys Lys Lys Phe Asp
 815                 820                 825                 830

 gaa tcg acg gac tac att tgc cca atg gag ccc agt gac ggt gtc agt     2724
 Glu Ser Thr Asp Tyr Ile Cys Pro Met Glu Pro Ser Asp Gly Val Ser
                 835                 840                 845

 gat agt cac agg gtc tac agt ggc tac cgg ggc ctc agc ccc ctt gat     2772
 Asp Ser His Arg Val Tyr Ser Gly Tyr Arg Gly Leu Ser Pro Leu Asp
             850                 855                 860

 gcc cct gaa ctg gat ggg ctg gac cag gtg gga cag att agc tgatgcc     2821
 Ala Pro Glu Leu Asp Gly Leu Asp Gln Val Gly Gln Ile Ser 
         865                 870                 875

 cttgtcacct gccctctgtg caccctgaga gctcacagta acactgtgtg tgtcaccata   2881

 taactgcacc tcacccccgc acgtgtgcat gactcgcaga gaatattcca gcaattgtgt   2941

 acccctgggc cagtctcttt gaaccctgag ggtggccagg atctggagct gcatctctaa   3001

 ggggccaggc tttggggacc attgccaaag gtggactcag gaggaaagac acttaaagac   3061

 acttttacat gtctagtaat tcttgatgtt catcttcagc accagtggaa acacatgaac   3121

 ttcgatgcag gtccagagac catggacact cccacgaggc tcagctctca ggcaccccct   3181

 acacttcagt tgagggaaaa gctcaagtgc cttaggcccg tggaccacag tcttggctga   3241

 gatcaaaggg atgagcaaca gggacttctg ccacagtgac aatggaattg tgttgtgcct   3301

 tacttcagag gtggtctctt ctttcttgta ataaaagcaa tatttatgcg gaaaaaaaaa   3361

 aa                                                                  3363




      <210> 86
      <211> 6586
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2943)

      <220>
      <221> misc_feature
      <222> (1)...(6586)
      <223> n = a,t,c or g

      <400> 86
  atg ggc tgc agg tcc ccg gac cta gct agt aag gac agc tat tat ctt      48
  Met Gly Cys Arg Ser Pro Asp Leu Ala Ser Lys Asp Ser Tyr Tyr Leu
    1               5                  10                  15

 aaa ggt ggc aga gag gcc cag agc cct tgg gcc tac cag ttc ctg agt       96
 Lys Gly Gly Arg Glu Ala Gln Ser Pro Trp Ala Tyr Gln Phe Leu Ser
              20                  25                  30

 aag act ggc tgg gct gca gac ttc tgg aat gca ggg atg gct cat gca      144
 Lys Thr Gly Trp Ala Ala Asp Phe Trp Asn Ala Gly Met Ala His Ala
          35                  40                  45

 cga gat ggc tgc agg ggc tgg gga gtg ggc tgc acc agc atc agt cct      192
 Arg Asp Gly Cys Arg Gly Trp Gly Val Gly Cys Thr Ser Ile Ser Pro
      50                  55                  60

 aca gct gaa ctg ggg ctg gtg ctg cca ggt gag ctg cca gct gcc cac      240
 Thr Ala Glu Leu Gly Leu Val Leu Pro Gly Glu Leu Pro Ala Ala His
  65                  70                  75                  80

 atc agc gtg gcg ctc cag gcg caa gga gtg agt aag ctg ccg cgc aaa      288
 Ile Ser Val Ala Leu Gln Ala Gln Gly Val Ser Lys Leu Pro Arg Lys
                  85                  90                  95

 gtc atg gct ggc aga ggg ttg agc agc ccc agg gat cgt ttc atc tct      336
 Val Met Ala Gly Arg Gly Leu Ser Ser Pro Arg Asp Arg Phe Ile Ser
             100                 105                 110

 aac ctc tca atc cac caa gga gca agc cag ggc cag agg gag ggt cct      384
 Asn Leu Ser Ile His Gln Gly Ala Ser Gln Gly Gln Arg Glu Gly Pro
         115                 120                 125

 ccc tgc atc gcc atc ctg gca gaa ctt gtg cca gcc ttt ttg gct ctt      432
 Pro Cys Ile Ala Ile Leu Ala Glu Leu Val Pro Ala Phe Leu Ala Leu
     130                 135                 140

 ctg ttt gag cag gcg gtt gga ccc gtg ccc ctc gcc tgc tgc cag cac      480
 Leu Phe Glu Gln Ala Val Gly Pro Val Pro Leu Ala Cys Cys Gln His
 145                 150                 155                 160

 aga ctg ccc act gtg ggg ctc ctg gct gct ggc tgg ggt tca agt ttg      528
 Arg Leu Pro Thr Val Gly Leu Leu Ala Ala Gly Trp Gly Ser Ser Leu
                 165                 170                 175

 ttg ggg gaa gca cct tgg ctg ggc cct gag ctc tgg gag aca cca cat      576
 Leu Gly Glu Ala Pro Trp Leu Gly Pro Glu Leu Trp Glu Thr Pro His
             180                 185                 190

 cag ctg gct ggg cct ctg gca gac ccc agc tcc aag tct ggt cct gag      624
 Gln Leu Ala Gly Pro Leu Ala Asp Pro Ser Ser Lys Ser Gly Pro Glu
         195                 200                 205

 gag ctg cag gcc cag att cct tca ggg gtg cta gcc gga gcc ctc ccg      672
 Glu Leu Gln Ala Gln Ile Pro Ser Gly Val Leu Ala Gly Ala Leu Pro
     210                 215                 220

 gag cgc tcg ggg ttc gac ccc cga gca cgg cgg gag gag ggc gcc ccc      720
 Glu Arg Ser Gly Phe Asp Pro Arg Ala Arg Arg Glu Glu Gly Ala Pro
 225                 230                 235                 240

 ctg cgg cac agc cac gtc cac gaa gcc cct ccc ggg gtt cta gaa agc      768
 Leu Arg His Ser His Val His Glu Ala Pro Pro Gly Val Leu Glu Ser
                 245                 250                 255

 gga ggc ctc cgc tgt gat ttg gac aga aat cag ctg cca cgt gca aca      816
 Gly Gly Leu Arg Cys Asp Leu Asp Arg Asn Gln Leu Pro Arg Ala Thr
             260                 265                 270

 ttc tcc cat ggg aac atg tgt ccg cag tac cta tct cag agc cca aat      864
 Phe Ser His Gly Asn Met Cys Pro Gln Tyr Leu Ser Gln Ser Pro Asn
         275                 280                 285

 cct tcc tgc ccc aca gcc ttc tcc tgg aac ctg cct tgg gct tac aca      912
 Pro Ser Cys Pro Thr Ala Phe Ser Trp Asn Leu Pro Trp Ala Tyr Thr
     290                 295                 300

 gct tac ctc tca gga atg cta cgt ttt gaa cat caa gaa tgg aaa gct      960
 Ala Tyr Leu Ser Gly Met Leu Arg Phe Glu His Gln Glu Trp Lys Ala
 305                 310                 315                 320

 gcc att gag gct ttt aac aaa tgc aaa act atc tat gag aag cta gcc     1008
 Ala Ile Glu Ala Phe Asn Lys Cys Lys Thr Ile Tyr Glu Lys Leu Ala
                 325                 330                 335

 agt gct ttc aca gag gag cag gct gtg ctg tat aac caa cgt gtg gaa     1056
 Ser Ala Phe Thr Glu Glu Gln Ala Val Leu Tyr Asn Gln Arg Val Glu
             340                 345                 350

 gag att tca ccc aac atc cgc tat tgt gca tat aat att ggg gac cag     1104
 Glu Ile Ser Pro Asn Ile Arg Tyr Cys Ala Tyr Asn Ile Gly Asp Gln
         355                 360                 365

 tca gcc atc aat gaa ctc atg cag atg aga ttg agg tct ggg ggc act     1152
 Ser Ala Ile Asn Glu Leu Met Gln Met Arg Leu Arg Ser Gly Gly Thr
     370                 375                 380

 gaa ggt ctc ttg gct gaa aaa ttg gag gct ttg atc act cag act cga     1200
 Glu Gly Leu Leu Ala Glu Lys Leu Glu Ala Leu Ile Thr Gln Thr Arg
 385                 390                 395                 400

 gcc aaa cag gca gct acc atg agt gaa gtg gag tgg aga ggg aga acg     1248
 Ala Lys Gln Ala Ala Thr Met Ser Glu Val Glu Trp Arg Gly Arg Thr
                 405                 410                 415

 gtt cca gtg aag att gac aaa gtg cgc att ttc tta tta gga ctg gct     1296
 Val Pro Val Lys Ile Asp Lys Val Arg Ile Phe Leu Leu Gly Leu Ala
             420                 425                 430

 gat aac gaa gca gct att gtc cag gct gaa agc gaa gaa act aag gag     1344
 Asp Asn Glu Ala Ala Ile Val Gln Ala Glu Ser Glu Glu Thr Lys Glu
         435                 440                 445

 cgc ctg ttt gaa tca atg ctc agc gag tgt cgg gac gcc atc cag gtg     1392
 Arg Leu Phe Glu Ser Met Leu Ser Glu Cys Arg Asp Ala Ile Gln Val
     450                 455                 460

 gtt cgg gag gag ctc aag cca gat cag aaa cag aga gat tat atc ctt     1440
 Val Arg Glu Glu Leu Lys Pro Asp Gln Lys Gln Arg Asp Tyr Ile Leu
 465                 470                 475                 480

 gaa gga gag cca ggg aag gtg tct aat ctt caa tac ttg cat agc tac     1488
 Glu Gly Glu Pro Gly Lys Val Ser Asn Leu Gln Tyr Leu His Ser Tyr
                 485                 490                 495

 ctg act tac atc aag cta tca acg gca atc aag cgt aat gag aac atg     1536
 Leu Thr Tyr Ile Lys Leu Ser Thr Ala Ile Lys Arg Asn Glu Asn Met
             500                 505                 510

 gcc aaa ggt ctg cag agg gct ctg ctg cag cag cag cca gag gat gac     1584
 Ala Lys Gly Leu Gln Arg Ala Leu Leu Gln Gln Gln Pro Glu Asp Asp
         515                 520                 525

 agc aag cgc tca ccc cgg ccc cag gac ctg atc cga ctc tat gac atc     1632
 Ser Lys Arg Ser Pro Arg Pro Gln Asp Leu Ile Arg Leu Tyr Asp Ile
     530                 535                 540

 atc tta cag aat ctg gtg gaa ttg ctc cag ctt cct ggt tta gag gaa     1680
 Ile Leu Gln Asn Leu Val Glu Leu Leu Gln Leu Pro Gly Leu Glu Glu
 545                 550                 555                 560

 gac aaa gcc ttc cag aaa gag ata ggc ctc aag act ctg gtg ttc aaa     1728
 Asp Lys Ala Phe Gln Lys Glu Ile Gly Leu Lys Thr Leu Val Phe Lys
                 565                 570                 575

 gct tac agg tgt ttt ttc att gct cag tcc tat gtg ctg gtg aag aag     1776
 Ala Tyr Arg Cys Phe Phe Ile Ala Gln Ser Tyr Val Leu Val Lys Lys
             580                 585                 590

 tgg agc gaa gcc ctt gtc ctg tat gac aga gtc ctg aaa tat gca aat     1824
 Trp Ser Glu Ala Leu Val Leu Tyr Asp Arg Val Leu Lys Tyr Ala Asn
         595                 600                 605

 gaa gta aat tct gat gct ggc gcc ttc aag aac agc cta aag gag gca     1872
 Glu Val Asn Ser Asp Ala Gly Ala Phe Lys Asn Ser Leu Lys Glu Ala
     610                 615                 620

 tcc gct cga cgg cgg gag att gag gac aag ctg aag cag gag gag gag     1920
 Ser Ala Arg Arg Arg Glu Ile Glu Asp Lys Leu Lys Gln Glu Glu Glu
 625                 630                 635                 640

 act ctg tcc ttc atc cga gac agc ctg gag aag agc gac cag ctc act     1968
 Thr Leu Ser Phe Ile Arg Asp Ser Leu Glu Lys Ser Asp Gln Leu Thr
                 645                 650                 655

 aag aac atg ggg aga ctg gaa aag cac aaa gtg tct atc tta tca tcc     2016
 Lys Asn Met Gly Arg Leu Glu Lys His Lys Val Ser Ile Leu Ser Ser
             660                 665                 670

 ttt gag agc cgc ctt atg aag ctg gag aac tcc atc atc cct gtg cac     2064
 Phe Glu Ser Arg Leu Met Lys Leu Glu Asn Ser Ile Ile Pro Val His
         675                 680                 685

 aag cag acg gag aat ctg cag cgg ctg cag gag aat gtt gag aag acg     2112
 Lys Gln Thr Glu Asn Leu Gln Arg Leu Gln Glu Asn Val Glu Lys Thr
     690                 695                 700

 ctg tcc tgc ctg gac cat gtc atc agc tac tac cat gtg gcc agt gac     2160
 Leu Ser Cys Leu Asp His Val Ile Ser Tyr Tyr His Val Ala Ser Asp
 705                 710                 715                 720

 act gag aag atc atc aga gag ggc ccc aca ggt agg ctg gaa gag tac     2208
 Thr Glu Lys Ile Ile Arg Glu Gly Pro Thr Gly Arg Leu Glu Glu Tyr
                 725                 730                 735

 ctg gga agc atg gcc aag att cag aag gca gtg gag tat ttc cag gac     2256
 Leu Gly Ser Met Ala Lys Ile Gln Lys Ala Val Glu Tyr Phe Gln Asp
             740                 745                 750

 aac agc cca gac agc ccg gaa ctc aac aaa gtg aaa ctg ctc ttt gag     2304
 Asn Ser Pro Asp Ser Pro Glu Leu Asn Lys Val Lys Leu Leu Phe Glu
         755                 760                 765

 cgc ggg aag gag gcc ctg gag tcc gaa ttt cgc agc ctg atg acg cgg     2352
 Arg Gly Lys Glu Ala Leu Glu Ser Glu Phe Arg Ser Leu Met Thr Arg
     770                 775                 780

 cac agt aag gtc gtc tcg ccc gtg ctc atc ttg gat ctg atc agt ggt     2400
 His Ser Lys Val Val Ser Pro Val Leu Ile Leu Asp Leu Ile Ser Gly
 785                 790                 795                 800

 gac gat gat ctg gag gcc cag gag gac gtg acc ctg gag cac ctg ccc     2448
 Asp Asp Asp Leu Glu Ala Gln Glu Asp Val Thr Leu Glu His Leu Pro
                 805                 810                 815

 gag agc gtg ctc cag gat gtc att cgc atc tcc cgc tgg ctg gtg gaa     2496
 Glu Ser Val Leu Gln Asp Val Ile Arg Ile Ser Arg Trp Leu Val Glu
             820                 825                 830

 tat ggc cgc aac caa gat ttc atg aac gtc tac tac cag ata cgc tcc     2544
 Tyr Gly Arg Asn Gln Asp Phe Met Asn Val Tyr Tyr Gln Ile Arg Ser
         835                 840                 845

 agc cag ctg gac cgc tcc atc aaa gga ctg aag gag cat ttc cat aag     2592
 Ser Gln Leu Asp Arg Ser Ile Lys Gly Leu Lys Glu His Phe His Lys
     850                 855                 860

 agc agt tct tcc tct ggg gtt ccc tac tcc cct gct atc ccc aac aag     2640
 Ser Ser Ser Ser Ser Gly Val Pro Tyr Ser Pro Ala Ile Pro Asn Lys
 865                 870                 875                 880

 agg aaa gac aca cct acc aag aag cca gtc aag cgg cca ggg acg atc     2688
 Arg Lys Asp Thr Pro Thr Lys Lys Pro Val Lys Arg Pro Gly Thr Ile
                 885                 890                 895

 cgt aag gct cag aac ctt ctg aaa cag tat tcc cag cat ggt cta gat     2736
 Arg Lys Ala Gln Asn Leu Leu Lys Gln Tyr Ser Gln His Gly Leu Asp
             900                 905                 910

 ggg aaa aag ggg ggc tct aac ctc att cct ctg gaa ggg aga gat gac     2784
 Gly Lys Lys Gly Gly Ser Asn Leu Ile Pro Leu Glu Gly Arg Asp Asp
         915                 920                 925

 atg ctg gac gtg gag acc gat gcc tac atc cac tgc cgt cag tgc ctt     2832
 Met Leu Asp Val Glu Thr Asp Ala Tyr Ile His Cys Arg Gln Cys Leu
     930                 935                 940

 cgt caa gct ggc gca gag cga gta cca gct gct ggc cga cat cat ccc     2880
 Arg Gln Ala Gly Ala Glu Arg Val Pro Ala Ala Gly Arg His His Pro
 945                 950                 955                 960

 cga gca cca cca gaa gaa gac ctt cga ctc cct gat aca gga tgc cct     2928
 Arg Ala Pro Pro Glu Glu Asp Leu Arg Leu Pro Asp Thr Gly Cys Pro
                 965                 970                 975

 gga tgg gct gat gct tgaaggggag aacatcgtgt ctgctgcccg gaaggccatt     2983
 Gly Trp Ala Asp Ala 
             980

 gtgcgacacg acttctccac ggtgctcacc gtcttcccca tcctgcgaca cctcaagcag   3043

 accaagcctg agtttgacca ggtgctccag ggcacggctg ccagcacaaa gaacaagctg   3103

 cctggcctca tcacatccat ggagaccatc ggtgccaaag cgctggagga cttcgcagac   3163

 aacatcaaga atgacccgga caaggagtac aacatgccga aggacggcac cgtacacgag   3223

 ctcaccagca atgccatcct cttcctgcag cagcttttgg acttccagga gacggcaggc   3283

 gccatgctgg cctcccaaga gaccagctct tcggccacca gctacagctc tgagttcagc   3343

 aagcggctgc taagcaccta tatctgtaaa gtgctgggca acctgcagtt gaacttgctg   3403

 agcaagtcca aggtgtacga ggacccagct ctgagcgcca tcttcctgca caacaactac   3463

 aattacatcc tcaagtccct ggagaagtct gaactgatcc agctggtggc agtgacacag   3523

 aagactgctg agcgctccta ccgggagcac attgagcagc agatccagac ctaccagcgc   3583

 agctggttaa aggtgactga ttacatcgca gagaagaatc tacctgtgtt ccagccggga   3643

 gtcaagctcc gggacaagga gcggcagatt atcaaggagc gttttaaggg cttcaatgat   3703

 ggcctcgaag aactgtgcaa aatccagaag gcctgggcta ttccagacac agagcagagg   3763

 gacaggattc gccaggccca gaagaccatt gtcaaggaga cctacggggc ctttctacag   3823

 aagtttggca gcgtgccctt caccaagaac ccggagaagt acatcaagta cggggtggag   3883

 caggtgggcg acatgatcga tcgccttttc gacacctctg cctgagcctg ctgctagccc   3943

 tgcctggttc caccagactg gcgtgtcatt ggacagataa accagtgtta gcttgcctct   4003

 gggctgggtg agcttgaagt cctctgggac agagacctgt ctccacgcct ccgggagctg   4063

 tgtccctgag ccccctagtc ctggctcctg ctttttcccc acagcccgtg ttcccagccg   4123

 aaccagcact ctcccggaag cctggggtcc ctccacacct tggcttttat gaccctgatg   4183

 gcttctgaaa caggaaaaga gagaaggaag acagaggcct gtgcccactg ctgctccatg   4243

 tgtaccaaga gcagcagggc agaagggccc tccctccagc ctaggtcaga ggtggggaca   4303

 gagaactccc ctacagccca gagatgtggc agggctcaga gaagcagcca gagctcctgg   4363

 aggaaaggca gtcgggactg accccctctc ttaaaacaca ttcccgcccg cccacaggcc   4423

 tgaggtctgg gacctttccc tcccaggagt cccctatgtg gctgggggag gcaggctcac   4483

 tggccatttt ccctagagtc cagcacactg caggaggcgt tcggaggagg agttccgccc   4543

 caccctctac agccttcctc aggcccctgt ctctggcccc cagcctcagt gcctcttggc   4603

 ccagggccag gcagtcgtgg ttgcagaagg agcaattagg ctgcctgcct gtgggctggg   4663

 agacagggac aatggggaaa agttaaggag caaaatgggg gttggaagca aaaaataggg   4723

 ccccacctat ttaggacgag attgaagact gacccttgag gcacacttgc actggagatg   4783

 ggtttatttc acgctctgtg cttgtgtgct agcggaggga gagctcaggg tggcttaatc   4843

 cagaggccct gtcatggccc gcccccagcc atgggaaagc aaacttcatc ctaaggtgtg   4903

 cagcccaggc cctgcccctt tacagtctag gccgcctgcc atggggtgca gcctctccag   4963

 gggctgcgtc agacttgcac gctgcccaca tccagattcc tgcaaagacg aattgggtgc   5023

 acagcacccc aaccacatac acgaggaaga agatgcggtc agcagtctca ggccagcttc   5083

 tctgtgaccc ctttactcct ctggagggct ctgtggggag agatacaggg aaaggagctg   5143

 ttcttcaagg tcccctcaac atgagcggaa gagcgaaccc caggggtcat cagcctgtat   5203

 cgcttccttt cttagattct cagctgatga aaatttgggt ctggcccatt tcaggccatc   5263

 ttcagttgaa gaaacaccct cttaggctgt gcaaggcatg ggttatcagg ggattgaggt   5323

 cacctgggac ttcagggagg ctcagcttgc tccctgcccc agacctgttt cttctaaggg   5383

 aggaggacat ggtggagacc agggacagga gagccagcag ggtggatgca aggggcctct   5443

 acccacacct ggacctccgt gccctcaccc cagccctagg tgtgcaccta ggcctcattc   5503

 cttacccccc agcccctgcc caccttcagc aggatgaggc cctgggttgc cgtgctctcg   5563

 ctgttcccct ctcggggctg ggctggggcc gctcttggcc ccaaggttgc cccgggccag   5623

 cagcccagcc agcagcacag tctctatggt gctgaggaag agcagcagca gcaggatggt   5683

 gaagtagtaa actgggggag gcagggcaca gggagatgct caggggccag tccctgtgtc   5743

 tctggtgccc agcgagctga gcaccagtgg gtgaccgggg agaaacaggg cagactgggt   5803

 aagggagcag ggcttactga gcagtgggtt gcaggaggag gagctgggca gggcctgcac   5863

 cagggaggag tggaggacga ggtaactcag cagcaatgtc accttgtagc ctatgcgctc   5923

 aatggcccgg aggggcagca accccccgca cacgtcagcc aacagcagtg cctctgcagg   5983

 caccaagaga gcgatgatgg acttgagcgc cgtgttcttc agcctcagct ggaaggggaa   6043

 aagtcagggc cttcccggcg ggggggaagg aggtgggcat cgggggcatg gggcctggcc   6103

 tctggccgtg catcctcact cccacccgcc tccagcagcc ctctgtcggc ctcctcccga   6163

 cttgactcac cgtcacctgg aagcagggca ccagctgctg gggtgggact tgggtcttca   6223

 gatcataaac tacgtattcc ctcttgacac tcacaatctc gttcaccacg tgggcctgga   6283

 actctaactc catcgctgag gggtgggaat gagaactatg aaccaggaag gagagatccc   6343

 agctgccaag tctgggggta gcagactgga gcccaggggt gatggagact tttgatggct   6403

 tttggcaggg acagacttgg acacaaaacc gatccataga agggcttccc aaaccttgtt   6463

 ttgcaacatc ccaaattgtc tccagttgaa ggaaggcctt tatcagattc atagatgagc   6523

 ttacattgta aaaataaatg tactttgcac cacttcnnnn nnnnnnnnng ggggcgccct   6583

 ttc                                                                 6586




      <210> 87
      <211> 1182
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (427)..(687)

      <400> 87
 gacgcgtggg taaaattgga agaactaaaa gttttagatt agagtcatag ccttaatagc     60

 cctaggtgtc atcctgggag acaggcaaca gtagagatat ttgagagcct aaagagaggt    120

 ttggcctgtg ggtttttaag tggttattga attggtatca ggagatcctg aggctggtag    180

 gggaaggtaa ttctttctaa gttacctctg tatttttcaa gttttctata aggaatacac    240

 atacacccac atgcacacac catagttttt atacaaacag caataacaaa accaaaaaga    300

 tgcccctttt tttgtaggga taagaaatac atttgtttta tacttctatg ctatattttg    360

 ctattcaaaa tttagtgggc attacttaac attgtttcta attattttgt ggctgctgta    420

 tgtttt   atg tgt tgg gag ccc att gta tta ggc cgt tct tgg att gct     468
          Met Cys Trp Glu Pro Ile Val Leu Gly Arg Ser Trp Ile Ala
            1               5                  10

 ata aag aaa tac ctg aga ctg ggt aat ttg gtt ttt tgg ttt ttt ggg      516
 Ile Lys Lys Tyr Leu Arg Leu Gly Asn Leu Val Phe Trp Phe Phe Gly
  15                  20                  25                  30

 gtt ttt ttt gag acg gag cct tgc tct gtc gcc cag gct gga gtg cag      564
 Val Phe Phe Glu Thr Glu Pro Cys Ser Val Ala Gln Ala Gly Val Gln
                  35                  40                  45

 tgg cgc gat ctc ggc tct atg caa cct cca cct cct ggg ttc atg cca      612
 Trp Arg Asp Leu Gly Ser Met Gln Pro Pro Pro Pro Gly Phe Met Pro
              50                  55                  60

 ttc tcc tgc ctc agc ctc ccg agt agc tgg gac tac agg cgc ccg cca      660
 Phe Ser Cys Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg Arg Pro Pro
          65                  70                  75

 cca tgc ctg gct aat ttt tta tat ttt tagta gagatggggt ttcaccgtat      712
 Pro Cys Leu Ala Asn Phe Leu Tyr Phe 
      80                  85

 gagccaggat ggtctcgatc tcctgacctc atgatccaca agactgggta atctgtaaag    772

 aaaagaggtt taattggctc atggctctgc aggctttaca ggaagcatgg tactggcatc    832

 tgcttggttt ctggggaggc ctccggaagc ttatagtcat ggcagaaggt gaagggggag    892

 caggcacatc acatgacaaa agcaggaaca agactcagag caagaagtca cttatcacca    952

 aggggatggc ccaggccatt caatgagggg atcaaccttg gtgctcaaaa aacctcccac   1012

 caggccccac ctccagaatg ggggattaca tttcaattta agtttgtgcc ggaacaaatt   1072

 acccaattta tttccccact tcaatggttc ccttttccta gaatgggagg tccacgaata   1132

 aattctgggc acctccaaat cttcccatga atgcaagggg tcttttggta              1182




      <210> 88
      <211> 537
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (170)..(412)

      <400> 88
 aaacggaaag gttcggaatt tgcctctgcg ccatcttttt ttgcctgtta cctgtgacgt     60

 ccttggaagc agaatctgaa actttctgag gagagcattt gagcttcaga tttctaacag    120

 cctctttgca acaaaataga ccagtagctg aaggcaactg caatccttc    atg atg     175
                                                          Met Met
                                                            1

 ttt ccc ttg gcc aga aat gca cta agc agt ctc aag att caa agc att      223
 Phe Pro Leu Ala Arg Asn Ala Leu Ser Ser Leu Lys Ile Gln Ser Ile
           5                  10                  15

 ctg caa agc atg gca aga cat agc cat gta aaa cac tca cca gat ttt      271
 Leu Gln Ser Met Ala Arg His Ser His Val Lys His Ser Pro Asp Phe
      20                  25                  30

 cat gat aaa tat ggt aat gct gtg cta gcc agt gga act gct ttc tgt      319
 His Asp Lys Tyr Gly Asn Ala Val Leu Ala Ser Gly Thr Ala Phe Cys
  35                  40                  45                  50

 gtt gct aca tgg gtg ttt aca gcc act cag att gga ata gaa tgg aac      367
 Val Ala Thr Trp Val Phe Thr Ala Thr Gln Ile Gly Ile Glu Trp Asn
                  55                  60                  65

 cta tcc cct gtt ggc aga gtt acc cca aaa gag tgg aaa cat cag taa      415
 Leu Ser Pro Val Gly Arg Val Thr Pro Lys Glu Trp Lys His Gln 
              70                  75                  80

 ccatcacagt tgctgtaatg acagaattgt ttaaaaaacc aacttgtcat gtaagcactc    475

 tactgcttat taaaatatag cacaattgaa aaaataaaat gtgttttaaa tctttaaaaa    535

 aa                                                                   537




      <210> 89
      <211> 1344
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (365)..(1174)

      <400> 89
 gaggctggac tcccgggtct gagggatgta tgggctggga tgctggactc ccgaatctga     60

 aggaggaggg gctgggggcc tggactcccg agtctgaggg aggagggact gaggcttctg    120

 gattcctggg tctgtgggag gagggactgg ggctcctgga ttcctgggtc tgtgggaaga    180

 gaggagtgtc tgagggagga ggggctgggg acaaacttcc aggtctctag ccttcctggc    240

 aacgcccccc gaggccggac ttccaggatc cagcctctat tgaggatttg atgcgacggc    300

 ctcacggggc tttggaggtg aaagaggccc agagtagaga gagagagaga ccgacgtaca    360

 cggg atg gct acg gga acg cgc tat gcc ggg aag gtg gtg gtc gtg acc     409
      Met Ala Thr Gly Thr Arg Tyr Ala Gly Lys Val Val Val Val Thr
        1               5                  10                  15

 ggg ggc ggg cgc ggc atc gga gct ggg atc gtg cgc gcc ttc gtg aac      457
 Gly Gly Gly Arg Gly Ile Gly Ala Gly Ile Val Arg Ala Phe Val Asn
                  20                  25                  30

 agc ggg gcc cga gtg gtt atc tgc gac aag gat gag tct ggg ggc cgg      505
 Ser Gly Ala Arg Val Val Ile Cys Asp Lys Asp Glu Ser Gly Gly Arg
              35                  40                  45

 gcc ctg gag cag gag ctc cct gga gct gtc ttt atc ctc tgt gat gtg      553
 Ala Leu Glu Gln Glu Leu Pro Gly Ala Val Phe Ile Leu Cys Asp Val
          50                  55                  60

 act cag gaa gat gat gtg aag acc ctg gtt tct gag acc atc cgc cga      601
 Thr Gln Glu Asp Asp Val Lys Thr Leu Val Ser Glu Thr Ile Arg Arg
      65                  70                  75

 ttt ggc cgc ctg gat tgt gtt gtc aac aac gct ggc cac cac cca ccc      649
 Phe Gly Arg Leu Asp Cys Val Val Asn Asn Ala Gly His His Pro Pro
  80                  85                  90                  95

 cca cag agg cct gag gag acc tct gcc cag gga ttc cgc cag ctg ctg      697
 Pro Gln Arg Pro Glu Glu Thr Ser Ala Gln Gly Phe Arg Gln Leu Leu
                 100                 105                 110

 gag ctg aac cta ctg ggg acg tac acc ttg acc aag ctc gcc ctc ccc      745
 Glu Leu Asn Leu Leu Gly Thr Tyr Thr Leu Thr Lys Leu Ala Leu Pro
             115                 120                 125

 tac ctg cgg aag agt caa ggg aat gtc atc aac atc tcc agc ctg gtg      793
 Tyr Leu Arg Lys Ser Gln Gly Asn Val Ile Asn Ile Ser Ser Leu Val
         130                 135                 140

 ggg gca atc ggc cag gcc cag gca gtt ccc tat gtg gcc acc aag ggg      841
 Gly Ala Ile Gly Gln Ala Gln Ala Val Pro Tyr Val Ala Thr Lys Gly
     145                 150                 155

 gca gta aca gcc atg acc aaa gct ttg gcc ctg gat gaa agt cca tat      889
 Ala Val Thr Ala Met Thr Lys Ala Leu Ala Leu Asp Glu Ser Pro Tyr
 160                 165                 170                 175

 ggt gtc cga gtc aac tgt atc tcc cca gga aac atc tgg acc ccg ctg      937
 Gly Val Arg Val Asn Cys Ile Ser Pro Gly Asn Ile Trp Thr Pro Leu
                 180                 185                 190

 tgg gag gag ctg gca gcc tta atg cca gac cct agg gcc aca atc cga      985
 Trp Glu Glu Leu Ala Ala Leu Met Pro Asp Pro Arg Ala Thr Ile Arg
             195                 200                 205

 gag ggc atg ctg gcc cag cca ctg ggc cgc atg ggc cag ccc gct gag     1033
 Glu Gly Met Leu Ala Gln Pro Leu Gly Arg Met Gly Gln Pro Ala Glu
         210                 215                 220

 gtc ggg gct gcg gca gtg ttc ctg gcc tcc gaa gcc aac ttc tgc acg     1081
 Val Gly Ala Ala Ala Val Phe Leu Ala Ser Glu Ala Asn Phe Cys Thr
     225                 230                 235

 ggc att gaa ctg ctc gtg acg ggg ggt gca gag ctg ggg tac ggg tgc     1129
 Gly Ile Glu Leu Leu Val Thr Gly Gly Ala Glu Leu Gly Tyr Gly Cys
 240                 245                 250                 255

 aag gcc agt cgg agc acc ccc gtg gac gcc ccc gat atc cct tcc tga     1177
 Lys Ala Ser Arg Ser Thr Pro Val Asp Ala Pro Asp Ile Pro Ser 
                 260                 265                 270

 tttctctcat ttctacttgg ggcccccttc ctaggactct cccaccccaa actccaacct   1237

 gtatcagatg cagcccccaa gcccttagac tctaagccca gttagcaagg tgccgggtca   1297

 ccctgcaggt tcccataaaa acgatttgca gccagaaaaa aaaaaaa                 1344




      <210> 90
      <211> 703
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (186)..(416)

      <220>
      <221> misc_feature
      <222> (1)...(703)
      <223> n = a,t,c or g

      <400> 90
 tttttttttt tttttagacg gagtctcact ctgtcaccca ggctggagtg cagtggtgcc     60

 attttggctc actgcagagg tttctgcctc ccgggttcaa gcgattctcc tgcctcatcc    120

 tcctgagtag ctgggactat aggccaggcc accatgcccg gctaattttt gtattttcag    180

 tagag    atg ggg ttt cac cat gtt tgc cag gct ggt ctc gaa ctc ctg     227
          Met Gly Phe His His Val Cys Gln Ala Gly Leu Glu Leu Leu
            1               5                  10

 acc tca ggt gat cca ccc gcc tca gcc tcc caa agt gct ggg att aca      275
 Thr Ser Gly Asp Pro Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr
  15                  20                  25                  30

 ggc atg agc cac cac gcc cag cct aac cat gga ctc tta ttt cct tcc      323
 Gly Met Ser His His Ala Gln Pro Asn His Gly Leu Leu Phe Pro Ser
                  35                  40                  45

 ctg cag aca tat caa aat tta aag aaa agg ttg gat att act tgg gca      371
 Leu Gln Thr Tyr Gln Asn Leu Lys Lys Arg Leu Asp Ile Thr Trp Ala
              50                  55                  60

 ttg gtc cct gtt tcc att ttg atg ata act gca gga ctg agt agt taa      419
 Leu Val Pro Val Ser Ile Leu Met Ile Thr Ala Gly Leu Ser Ser 
          65                  70                  75

 ctaattatga catcttctca cttcttttct caatataaat aaccaaacat caactctgta    479

 aacatttaga actcttgaac anttcanagt ttcaaataca ctcacgagaa atgaagatgt    539

 ggtcttgtac aaagaacctg tgcatgtagg tagacactga agtcacttcc aaggcacata    599

 aggcataacc tacctgctct catagagcct ttccctgcca gtcgaacgag gccctttctt    659

 tccaacatga aactccctcc attgaaaatg ctggagcctc atac                     703




      <210> 91
      <211> 2073
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (561)..(1343)

      <220>
      <221> misc_feature
      <222> (1)...(2073)
      <223> n = a,t,c or g

      <400> 91
 tatattttaa aaaccagcaa gtaaacggga aagggaggaa gcaagaagca cttcgaggtg     60

 ccagcgagca ccctggcgtc caagagcagc gcgcgggacc cgctgagccc agggcccggg    120

 ccgagctccg cccctttctc caggctcccc gccnccggag ggagagaggg aggacccgtc    180

 acaggtaacg atgcgcccag tgagcgtcct ttcctctggg gccaaccagc gtctccgcgc    240

 cgctgccgcc aacctcgcgc cgaactacgc cctgagattt gggcgggtag cgattggggg    300

 aaaacaggca acctaagagt tattaccgtt agcagcgaag actgcgacta acgtcaacga    360

 cggagactgc gtctgccttc gcttccgcct cgtagccccg ggaaccggaa atccgtctgc    420

 cccgggtcac gtgcttagga gccatattgt cgctagtggc cgctggggct gggaggggtg    480

 tgctagagag gcgcagcttc tctgggcgtg gtttttatcc tgggggaagg atcggtggaa    540

 tgtgagggga ggtggaggag    atg gcg gcg acg gcc cgg gaa gat ggc gcc     590
                          Met Ala Ala Thr Ala Arg Glu Asp Gly Ala
                            1               5                  10

 agc ggt caa gag cga ggt cag cgg ggc tgc gag cac tat gac aga gga      638
 Ser Gly Gln Glu Arg Gly Gln Arg Gly Cys Glu His Tyr Asp Arg Gly
                  15                  20                  25

 tgt ctc cta aag gca cct tgc tgt gac aag ctt tat act tgc cgc ttg      686
 Cys Leu Leu Lys Ala Pro Cys Cys Asp Lys Leu Tyr Thr Cys Arg Leu
              30                  35                  40

 tgt cat gat aac aat gaa gat cat caa cta gat cgc ttt aaa gtg aag      734
 Cys His Asp Asn Asn Glu Asp His Gln Leu Asp Arg Phe Lys Val Lys
          45                  50                  55

 gaa gtg cag tgc ata aac tgt gaa aaa att caa cat gcc caa cag act      782
 Glu Val Gln Cys Ile Asn Cys Glu Lys Ile Gln His Ala Gln Gln Thr
      60                  65                  70

 tgt gaa gaa tgt agc aca ttg ttt gga gaa tat tat tgc gat ata tgc      830
 Cys Glu Glu Cys Ser Thr Leu Phe Gly Glu Tyr Tyr Cys Asp Ile Cys
  75                  80                  85                  90

 cat ttg ttt gac aaa gat aag aag cag tat cac tgt gaa aac tgt gga      878
 His Leu Phe Asp Lys Asp Lys Lys Gln Tyr His Cys Glu Asn Cys Gly
                  95                 100                 105

 att tgt agg att ggt cca aag gaa gat ttt ttc cat tgt ttg aaa tgt      926
 Ile Cys Arg Ile Gly Pro Lys Glu Asp Phe Phe His Cys Leu Lys Cys
             110                 115                 120

 aac tta tgc cta gct atg aat ctt caa gga aga cac aag tgt att gaa      974
 Asn Leu Cys Leu Ala Met Asn Leu Gln Gly Arg His Lys Cys Ile Glu
         125                 130                 135

 aat gtg tcc cga cag aat tgt cca ata tgt ttg gag gac att cac aca     1022
 Asn Val Ser Arg Gln Asn Cys Pro Ile Cys Leu Glu Asp Ile His Thr
     140                 145                 150

 tcc cgt gtt gtt gct cat gtc ttg cca tgt gga cat ctt tta cat aga     1070
 Ser Arg Val Val Ala His Val Leu Pro Cys Gly His Leu Leu His Arg
 155                 160                 165                 170

 acg tgt tat gaa gaa atg ttg aaa gaa ggc tac aga tgt cca tta tgt     1118
 Thr Cys Tyr Glu Glu Met Leu Lys Glu Gly Tyr Arg Cys Pro Leu Cys
                 175                 180                 185

 atg cac tct gct tta gat atg acc agg tat tgg aga cag ctg gat gat     1166
 Met His Ser Ala Leu Asp Met Thr Arg Tyr Trp Arg Gln Leu Asp Asp
             190                 195                 200

 gaa gta gca cag act cct atg cca tca gaa tat cag aac atg act gtg     1214
 Glu Val Ala Gln Thr Pro Met Pro Ser Glu Tyr Gln Asn Met Thr Val
         205                 210                 215

 gat att ctc tgc aat gac tgt aat gga cga tcc act gtt cag ttt cat     1262
 Asp Ile Leu Cys Asn Asp Cys Asn Gly Arg Ser Thr Val Gln Phe His
     220                 225                 230

 ata tta ggc atg aaa tgt aag att tgt gaa tcc tat aat act gct caa     1310
 Ile Leu Gly Met Lys Cys Lys Ile Cys Glu Ser Tyr Asn Thr Ala Gln
 235                 240                 245                 250

 gct gga gga cgt aga att tca ctg gat cag caa tgacgagc ctacacagta     1361
 Ala Gly Gly Arg Arg Ile Ser Leu Asp Gln Gln 
                 255                 260

 ctggagaact tggcattttc tgatatagaa aaaggctttc cttggtatcg tgttatcatg   1421

 tgtcgtcatc tatgcattag agttgatgtg ttttgtacta gtgtcacagc ataaaatcat   1481

 attacaagta cgtaaggatt cagggtctct tgatagactt atcatagctc tatattgaat   1541

 gaaagccact gtgcttgtgt tttgattgga aattccttta gtgtcagttt tttggaagcc   1601

 aatgatgttt gccactgata cattcataga agtgtattat attttcatga agctttgctt   1661

 taagtgacac tacgcgtgca gttcatttct agttcttgat agaactgcac ttaattttca   1721

 gtagtagtct tgacttttta agggctgtgt tatattaagt tctcccttac tgttaaaacc   1781

 taattaaata tgctttagaa ttttctaaga cagtcctctg gatcctctaa atgtgaattt   1841

 tgatgtaata actgctaata aaattatatt gaaactgttt tatagaaagt tttttccaaa   1901

 gttttctatg tttggctcaa ttagggcagt atcatcagtt ctataatgta aaagaaattt   1961

 tctttctttt gaggtattcc ataaaagtag ttgggaaaat tattatgtaa aataataaga   2021

 ctcttccaaa gccttaataa aaacatcaac attgaaaaca aaaaaaaaaa aa           2073




      <210> 92
      <211> 1503
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (812)..(1384)

      <400> 92
 gacgcgtggg cagcgtcgga agtggaagct gaacctgatt gcagagttgg agtccagagt     60

 tctggctgag cctgtccctc tgccagccga gtgagtgcat ggctgccccc ctagggcctg    120

 ttttacttga gttcaacagc agagccctgg cttctgctgg ccagcttgcc ccttttggtg    180

 ggacttttag tcactgcctt gacctcaggt gggagctctc attatcagtc atctgttggg    240

 cttgctgttg acacctgact gcccttgtga agctacctga gaccgcctcc tgacatatgg    300

 aggaaagtct tattttgagt cctgggtgtc accctttttt caggtatagt aaacttatcc    360

 tccacagggc ccaaggccct gtggctgagg gcagataatg taggtctcac cgtgaggtgg    420

 tcgtttgaaa aagtgccctg aatgatttgt ctgctctctc cctagaatat gccctacaga    480

 gataggtata ttcagccaca ttttccattc agggtagcaa acagtatgcc agatttggct    540

 tgcagatggg gttttggccc acatattttt taaaatttca cataaaatat tcattgagga    600

 gtccagattt ttagcctctc ttgtaaagtt ggactctggc agtgcagatc cacattccca    660

 catggcatca aagttcccct ttgaagagca cgccctttgc ctttctcctt cacttgtctg    720

 gccctggtgg gctgtgtagt ctgccaccct caggggattc gttttccagc caaaccttgc    780

 tcggccactg ttcttatctc catgcagccc a   atg gaa ctg aaa aat ctg gag     832
                                      Met Glu Leu Lys Asn Leu Glu
                                        1               5

 tat agg cca gtg aag gtc agg ggg tgc ttt gac cat tcc aag gag ctg      880
 Tyr Arg Pro Val Lys Val Arg Gly Cys Phe Asp His Ser Lys Glu Leu
          10                  15                  20

 tat atg atg ccc cgg acc atg gtg gac cct gtc cgg gag gcc cgg gag      928
 Tyr Met Met Pro Arg Thr Met Val Asp Pro Val Arg Glu Ala Arg Glu
      25                  30                  35

 ggc ggc ctc atc tcc tcc tca act cag agt ggg gcc tat gtg gtc act      976
 Gly Gly Leu Ile Ser Ser Ser Thr Gln Ser Gly Ala Tyr Val Val Thr
  40                  45                  50                  55

 ccc ttc cac tgc acc gac ctg gga gtc acc atc ctg gta aat aga ggg     1024
 Pro Phe His Cys Thr Asp Leu Gly Val Thr Ile Leu Val Asn Arg Gly
                  60                  65                  70

 ttc gtt ccc agg aag aaa gtg aat cct gaa acc cgg cag aaa ggc cag     1072
 Phe Val Pro Arg Lys Lys Val Asn Pro Glu Thr Arg Gln Lys Gly Gln
              75                  80                  85

 att gag gga gaa gtg gac ctc att ggg atg gtg agg ctg aca gaa acc     1120
 Ile Glu Gly Glu Val Asp Leu Ile Gly Met Val Arg Leu Thr Glu Thr
          90                  95                 100

 agg cag cct ttt gtc cct gag aac aat cca gaa agg aac cac tgg cat     1168
 Arg Gln Pro Phe Val Pro Glu Asn Asn Pro Glu Arg Asn His Trp His
     105                 110                 115

 tat cga gac ctg gaa gct atg gcc aga atc aca ggc gca gag ccc atc     1216
 Tyr Arg Asp Leu Glu Ala Met Ala Arg Ile Thr Gly Ala Glu Pro Ile
 120                 125                 130                 135

 ttc att gat gcc aac ttc cag agc aca gtc cct gga gga ccc att gga     1264
 Phe Ile Asp Ala Asn Phe Gln Ser Thr Val Pro Gly Gly Pro Ile Gly
                 140                 145                 150

 ggg caa acc aga gtt act ctg agg aac gag cat ctg cag tac atc gtg     1312
 Gly Gln Thr Arg Val Thr Leu Arg Asn Glu His Leu Gln Tyr Ile Val
             155                 160                 165

 acc tgg tat gga ctc tct gca gct aca tcc tac ctg tgg ttt aag aaa     1360
 Thr Trp Tyr Gly Leu Ser Ala Ala Thr Ser Tyr Leu Trp Phe Lys Lys
         170                 175                 180

 ttc cta cgt ggg aca cct ggt gtg tgacagatca gctgctgaag ccctgtccct    1414
 Phe Leu Arg Gly Thr Pro Gly Val 
     185                 190

 ggataatgca gtatttcaag actgccttta tgctggatca tgtgctactg gtataaagtt   1474

 ctggccttct accttaaaaa aaaaaaaaa                                     1503




      <210> 93
      <211> 1721
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (284)..(1339)

      <220>
      <221> misc_feature
      <222> (1)...(1721)
      <223> n = a,t,c or g

      <400> 93
 gttctagatc gcgagcggcc gctcgcgatc tataatgcct cttctgaagc agccatcccg     60

 gcctcttggt actgctgacc ccagccaggc tacagggatc gattggagct gtccttgggg    120

 ctgtaattgg ccccagctga gcagggcaaa cactgaggtc aactacaagc cacaggcccc    180

 ttccccagcc tcagttcaca gctgccctgt tgcagggagg cggtggccct tctgttgcta    240

 gaccgagcct gtgggatata ccaaggcaga ggagcccata gcc  atg agg agc ctc     295
                                                  Met Arg Ser Leu
                                                    1

 ggg gcc ctg ctc ttg ctg ctg agc gcc tgc ctg gcg gtg agc gct ggc      343
 Gly Ala Leu Leu Leu Leu Leu Ser Ala Cys Leu Ala Val Ser Ala Gly
   5                  10                  15                  20

 cct gtg cca acg ccg ccc gac aac atc caa gtg cag gaa aac ttc aat      391
 Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe Asn
                  25                  30                  35

 atc tct cgg atc tat ggg aag tgg tac aac ctg gcc atc ggt tcc acc      439
 Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr
              40                  45                  50

 tgc ccc tgg ctg aag aag atc atg gac agg atg aca gtg agc acg ctg      487
 Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val Ser Thr Leu
          55                  60                  65

 gtg ctg gga gag ggc gct aca gag gcg gag atc agc atg acc agc act      535
 Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser Thr
      70                  75                  80

 cgt tgg cgg aaa ggt gtc tgt gag gag acg tct gga gct tat gag aaa      583
 Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys
  85                  90                  95                 100

 aca gat act gat ggg aag ttt ctc tat cac aaa tcc aaa tgg aac ata      631
 Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asn Ile
                 105                 110                 115

 acc atg gag tcc tat gtg gtc cac acc aac tat gat gag tat gcc att      679
 Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile
             120                 125                 130

 ttc ctg acc aag aaa ttc agc cgc cat cat gga ccc acc att act gcc      727
 Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr Ala
         135                 140                 145

 aag ctc tac ggg cgg gcg ccg cag ctg agg gaa act ctc ctg cag gac      775
 Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp
     150                 155                 160

 ttc aga gtg gtt gcc cag ggt gtg ggc atc cct gag gac tcc atc ttc      823
 Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile Phe
 165                 170                 175                 180

 acc atg gct gac cga ggt gaa tgt gtc cct ggg gag cag gaa cca gag      871
 Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro Glu
                 185                 190                 195

 ccc atc tta atc ccg aga gtc cgg agg gct gtg cta ccc caa gaa gag      919
 Pro Ile Leu Ile Pro Arg Val Arg Arg Ala Val Leu Pro Gln Glu Glu
             200                 205                 210

 gaa gga tca ggg ggt ggg caa ctg gta act gaa gtc acc aag aaa gaa      967
 Glu Gly Ser Gly Gly Gly Gln Leu Val Thr Glu Val Thr Lys Lys Glu
         215                 220                 225

 gat tcc tgc cag ctg ggc tac tcg gcc ggt ccc tgc atg gga atg acc     1015
 Asp Ser Cys Gln Leu Gly Tyr Ser Ala Gly Pro Cys Met Gly Met Thr
     230                 235                 240

 agc agg tat ttc tat aat ggt aca tcc atg gcc tgt gag act ttc cag     1063
 Ser Arg Tyr Phe Tyr Asn Gly Thr Ser Met Ala Cys Glu Thr Phe Gln
 245                 250                 255                 260

 tac ggc ggc tgc atg ggc aac ggt aac aac ttc gtc aca gaa aag gag     1111
 Tyr Gly Gly Cys Met Gly Asn Gly Asn Asn Phe Val Thr Glu Lys Glu
                 265                 270                 275

 tgt ctg cag acc tgc cga act gtg gcg gcc tgc aat ctc ccc ata gtc     1159
 Cys Leu Gln Thr Cys Arg Thr Val Ala Ala Cys Asn Leu Pro Ile Val
             280                 285                 290

 cgg ggc ccc tgc cga gcc ttc atc cag ctc tgg gca ttt gat gct gtc     1207
 Arg Gly Pro Cys Arg Ala Phe Ile Gln Leu Trp Ala Phe Asp Ala Val
         295                 300                 305

 aag ggg aag tgc gtc ctc ttc ccc tac ggg ggc tgc cag ggc aac ggg     1255
 Lys Gly Lys Cys Val Leu Phe Pro Tyr Gly Gly Cys Gln Gly Asn Gly
     310                 315                 320

 aac aag ttc tac tca gag aag gag tgc aga gag tac tgc ggt gtc cct     1303
 Asn Lys Phe Tyr Ser Glu Lys Glu Cys Arg Glu Tyr Cys Gly Val Pro
 325                 330                 335                 340

 ggt gat ggt gat gag gag ctg ctg cgc ttc tcc aac tgac aactggccgg     1353
 Gly Asp Gly Asp Glu Glu Leu Leu Arg Phe Ser Asn 
                 345                 350

 tctgcaagtc agaggatggc cagtgtctgt cccggggtcc tgtggcaggc agcgccaagc   1413

 aacctgggtc caaataaaaa ctaaattgta aactcctaaa aaaaaaaaaa aaaaaaaaaa   1473

 agggggggcc gtttaaaaga atcaaatttt acttccccgg gaatgaaaaa aaaaattttt   1533

 tttatggggc ccccaaaatt aaatccctgg gccggctttt aaaaacgcgg gaaggggaaa   1593

 aacctggggg tacccaaatt aaatcccttt gaaaaaaatc cccttttccc cgggggggga   1653

 aaaacaaaaa agcgccggnn nnnnnnnntt nnnnnnnttc nttgaatata atctcggcca   1713

 cccccaaa                                                            1721




      <210> 94
      <211> 2535
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (85)..(2262)

      <400> 94
 gcacgaggcg acttccgggg cggcggttgc atcagattct aggaagtgtc tgtagccgca     60

 gctgcgggtc cgggattccc agcc   atg gca gat tcc tcc ggg cag cag ggc     111
                              Met Ala Asp Ser Ser Gly Gln Gln Gly
                                1               5

 aaa ggc cgg cgt gtg cag ccc cag tgg tcc cct cct gct ggg acc cag      159
 Lys Gly Arg Arg Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln
  10                  15                  20                  25

 cca tgc aga ctc cac ctt tac aac agc ctc acc agg aac aag gaa gtg      207
 Pro Cys Arg Leu His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Glu Val
                  30                  35                  40

 ttc ata cct caa gat ggg aaa aag gtg acg tgg tat tgc tgt ggg cca      255
 Phe Ile Pro Gln Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro
              45                  50                  55

 acc gtc tat gac gca tct cac atg ggg cac gcc agg tcc tac atc tct      303
 Thr Val Tyr Asp Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser
          60                  65                  70

 ttt gat atc ttg aga aga gtg ttg aag gat tac ttc aaa ttt gat gtc      351
 Phe Asp Ile Leu Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val
      75                  80                  85

 ttt tat tgc atg aac att acg gat att gat gac aag atc atc aag agg      399
 Phe Tyr Cys Met Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg
  90                  95                 100                 105

 gcc cgg cag aac cac ctg ttc gag cag tat cgg gag aag agg cct gaa      447
 Ala Arg Gln Asn His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu
                 110                 115                 120

 gcg gca cag ctc ttg gag gat gtt cag gcc gcc ctg aag cca ttt tca      495
 Ala Ala Gln Leu Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser
             125                 130                 135

 gta aaa tta aat gag acc acg gat ccc gat aaa aag cag atg ctc gaa      543
 Val Lys Leu Asn Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu
         140                 145                 150

 cgg att cag cac gca gtg cag ctt gcc aca gag cca ctt gag aaa gct      591
 Arg Ile Gln His Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala
     155                 160                 165

 gtg cag tcc aga ctc acg gga gag gaa gtc aac agc tgt gtg gag gtg      639
 Val Gln Ser Arg Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val
 170                 175                 180                 185

 ttg ctg gaa gaa gcc aag gat ttg ctc tct gac tgg ctg gat tct aca      687
 Leu Leu Glu Glu Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr
                 190                 195                 200

 ctt ggc tgt gat gtc act gac aat tcc atc ttc tcc aag ctg ccc aag      735
 Leu Gly Cys Asp Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys
             205                 210                 215

 ttc tgg gag ggg gac ttc cac aga gac atg gaa gct ctg aat gtt ctc      783
 Phe Trp Glu Gly Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu
         220                 225                 230

 cct cca gat gtc tta acc cgg gtt agt gag tat gtg cca gaa att gtg      831
 Pro Pro Asp Val Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val
     235                 240                 245

 aac ttt gtc cag aag att gtg gac aac ggt tac ggc tat gtc tcc aat      879
 Asn Phe Val Gln Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn
 250                 255                 260                 265

 ggg tct gtc tac ttt gat aca gcg aag ttt gct tct agc gag aag cac      927
 Gly Ser Val Tyr Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His
                 270                 275                 280

 tcc tat ggg aag ctg gtg cct gag gcc gtt gga gat cag aaa gcc ctt      975
 Ser Tyr Gly Lys Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu
             285                 290                 295

 caa gaa ggg gaa ggt gac ctg agc atc tct gca gac cgc ctg agt gag     1023
 Gln Glu Gly Glu Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu Ser Glu
         300                 305                 310

 aag cgc tct ccc aac gac ttt gcc tta tgg aag gcc tct aag ccc gga     1071
 Lys Arg Ser Pro Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys Pro Gly
     315                 320                 325

 gaa ccg tcc tgg ccg tgc cct tgg gga aag ggt cgt ccg ggc tgg cat     1119
 Glu Pro Ser Trp Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly Trp His
 330                 335                 340                 345

 atc gag tgc tcg gcc atg gca ggc acc ctc cta ggg gct tcg atg gac     1167
 Ile Glu Cys Ser Ala Met Ala Gly Thr Leu Leu Gly Ala Ser Met Asp
                 350                 355                 360

 att cac gga ggt ggg ttc gac ctc cgg ttc ccc cac cat gac aat gag     1215
 Ile His Gly Gly Gly Phe Asp Leu Arg Phe Pro His His Asp Asn Glu
             365                 370                 375

 ctg gca cag tcg gag gcc tac ttt gaa aac gac tgc tgg gtc agg tac     1263
 Leu Ala Gln Ser Glu Ala Tyr Phe Glu Asn Asp Cys Trp Val Arg Tyr
         380                 385                 390

 ttc ctg cac aca ggc cac ctg acc att gca ggc tgc aaa atg tca aag     1311
 Phe Leu His Thr Gly His Leu Thr Ile Ala Gly Cys Lys Met Ser Lys
     395                 400                 405

 tca cta aaa aac ttc atc acc att aaa gat gcc ttg aaa aag cac tca     1359
 Ser Leu Lys Asn Phe Ile Thr Ile Lys Asp Ala Leu Lys Lys His Ser
 410                 415                 420                 425

 gca cgg cag ttg cgg ctg gcc ttc ctc atg cac tcg tgg aag gac acc     1407
 Ala Arg Gln Leu Arg Leu Ala Phe Leu Met His Ser Trp Lys Asp Thr
                 430                 435                 440

 ctg gac tac tcc agc aac acc atg gag tca gcg ctt caa tat gag aag     1455
 Leu Asp Tyr Ser Ser Asn Thr Met Glu Ser Ala Leu Gln Tyr Glu Lys
             445                 450                 455

 ttc ttg aat gag ttt ttc tta aat gtg aaa gat atc ctt cgc gct cct     1503
 Phe Leu Asn Glu Phe Phe Leu Asn Val Lys Asp Ile Leu Arg Ala Pro
         460                 465                 470

 gtt gac atc act ggt cag ttt gag aag tgg gga gaa gaa gaa gca gaa     1551
 Val Asp Ile Thr Gly Gln Phe Glu Lys Trp Gly Glu Glu Glu Ala Glu
     475                 480                 485

 ctg aat aag aac ttt tat gac aag aag aca gca att cac aaa gcc ctc     1599
 Leu Asn Lys Asn Phe Tyr Asp Lys Lys Thr Ala Ile His Lys Ala Leu
 490                 495                 500                 505

 tgt gac aat gtt gac acc cgc acc gtc atg gaa gag atg cgg gcc ttg     1647
 Cys Asp Asn Val Asp Thr Arg Thr Val Met Glu Glu Met Arg Ala Leu
                 510                 515                 520

 gtc agt cag tgc aac ctc tat atg gca gcc cgg aaa gcc gtg agg aag     1695
 Val Ser Gln Cys Asn Leu Tyr Met Ala Ala Arg Lys Ala Val Arg Lys
             525                 530                 535

 agg ccc aac cag gct ctg ctg gag aac atc gcc ctg tac ctc acc cat     1743
 Arg Pro Asn Gln Ala Leu Leu Glu Asn Ile Ala Leu Tyr Leu Thr His
         540                 545                 550

 atg ctg aag atc ttt ggg gcc gta gaa gag gac agc tcc ctg gga ttc     1791
 Met Leu Lys Ile Phe Gly Ala Val Glu Glu Asp Ser Ser Leu Gly Phe
     555                 560                 565

 ccg gtc gga ggg cct gga acc agc ctc agt ctc gag gcc aca gtc atg     1839
 Pro Val Gly Gly Pro Gly Thr Ser Leu Ser Leu Glu Ala Thr Val Met
 570                 575                 580                 585

 ccc tac ctt cag gtg tta tca gaa ttc cga gaa gga gtg cgg aag att     1887
 Pro Tyr Leu Gln Val Leu Ser Glu Phe Arg Glu Gly Val Arg Lys Ile
                 590                 595                 600

 gcc cga gag caa aaa gtc cct gag att ctg cag ctc agc gat gcc ctg     1935
 Ala Arg Glu Gln Lys Val Pro Glu Ile Leu Gln Leu Ser Asp Ala Leu
             605                 610                 615

 cgg gac aac atc ctg ccc gag ctt ggg gtg cgg ttt gaa gac cac gaa     1983
 Arg Asp Asn Ile Leu Pro Glu Leu Gly Val Arg Phe Glu Asp His Glu
         620                 625                 630

 gga ctg ccc aca gtg gtg aaa ctg gta gac aga aac acc tta tta aaa     2031
 Gly Leu Pro Thr Val Val Lys Leu Val Asp Arg Asn Thr Leu Leu Lys
     635                 640                 645

 gag aga gaa gaa aag aga cgg gtt gaa gag gag aag agg aag aag aaa     2079
 Glu Arg Glu Glu Lys Arg Arg Val Glu Glu Glu Lys Arg Lys Lys Lys
 650                 655                 660                 665

 gag gag gcg gcc cgg agg aaa cag gaa caa gaa gca gca aag ctg gcc     2127
 Glu Glu Ala Ala Arg Arg Lys Gln Glu Gln Glu Ala Ala Lys Leu Ala
                 670                 675                 680

 aag atg aag att ccc ccc agt gag atg ttc ttg tca gaa acc gac aaa     2175
 Lys Met Lys Ile Pro Pro Ser Glu Met Phe Leu Ser Glu Thr Asp Lys
             685                 690                 695

 tac tcc aag ttt gat gaa aat gta agc atg gtc tgc cca cac atg aca     2223
 Tyr Ser Lys Phe Asp Glu Asn Val Ser Met Val Cys Pro His Met Thr
         700                 705                 710

 tgg agg gca aag agc tca gca aag ggc aag cca aga agc tgaagaagct      2272
 Trp Arg Ala Lys Ser Ser Ala Lys Gly Lys Pro Arg Ser 
     715                 720                 725

 cttcgaggct caggagaagc tctacaagga atatctgcag atggcccaga atggaagctt   2332

 ccagtgaggg ggcacaggac tgacttttta aaccattgtg gactagtggc tgctgtctgc   2392

 ctcagtgaca atgtcccagc gctcctatca tgtttacagt cacccttggg tcctaaatta   2452

 agagttgtgt tcatgtaggt tcgtgtcgtc gttggctctg agacattgat aataaatttt   2512

 tctcaacagt gaaaaaaaaa aaa                                           2535




      <210> 95
      <211> 874
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (86)..(634)

      <400> 95
 cgcggagggc cggagacgct gcagacccgc gacccggagc agctcggagg cggtgaataa     60

 tagctcttca agtctgcaat aaaaa  atg gcc tcc aac aaa act aca ttg caa     112
                              Met Ala Ser Asn Lys Thr Thr Leu Gln
                                1               5

 aaa atg gga aaa aaa cag aat gga aag agt aaa aaa gtt gaa gag gca      160
 Lys Met Gly Lys Lys Gln Asn Gly Lys Ser Lys Lys Val Glu Glu Ala
  10                  15                  20                  25

 gag cct gaa gaa ttt gtc gtg gaa aaa gta cta gat cga cgt gta gtg      208
 Glu Pro Glu Glu Phe Val Val Glu Lys Val Leu Asp Arg Arg Val Val
                  30                  35                  40

 aat ggg aaa gtg gaa tat ttc ctg aag tgg aag gga ttt aca gat gct      256
 Asn Gly Lys Val Glu Tyr Phe Leu Lys Trp Lys Gly Phe Thr Asp Ala
              45                  50                  55

 gac aat act tgg gaa cct gaa gaa aat tta gat tgt cca gaa ttg att      304
 Asp Asn Thr Trp Glu Pro Glu Glu Asn Leu Asp Cys Pro Glu Leu Ile
          60                  65                  70

 gaa gcg ttt ctt aac tct cag aaa gct ggc aaa gaa aaa gat ggt aca      352
 Glu Ala Phe Leu Asn Ser Gln Lys Ala Gly Lys Glu Lys Asp Gly Thr
      75                  80                  85

 aaa aga aaa tct tta tct gac agt gaa tct gat gac agc aaa tca aag      400
 Lys Arg Lys Ser Leu Ser Asp Ser Glu Ser Asp Asp Ser Lys Ser Lys
  90                  95                 100                 105

 aag aaa aga gat gct gct gac aaa cca aga gga ttt gcc aga ggt ctt      448
 Lys Lys Arg Asp Ala Ala Asp Lys Pro Arg Gly Phe Ala Arg Gly Leu
                 110                 115                 120

 gat cct gaa aga ata att ggt gcc aca gac agc agt gga gaa ttg atg      496
 Asp Pro Glu Arg Ile Ile Gly Ala Thr Asp Ser Ser Gly Glu Leu Met
             125                 130                 135

 ttt ctc atg aaa tgg aaa gat tca gat gag gca gac ttg gtg ctg gcg      544
 Phe Leu Met Lys Trp Lys Asp Ser Asp Glu Ala Asp Leu Val Leu Ala
         140                 145                 150

 aaa gag gca aat atg aag tgt cct caa att gta att gct ttt tat gaa      592
 Lys Glu Ala Asn Met Lys Cys Pro Gln Ile Val Ile Ala Phe Tyr Glu
     155                 160                 165

 gag aga cta act tgg cat tct tgt cca gaa gat gaa gct caa taattgt      641
 Glu Arg Leu Thr Trp His Ser Cys Pro Glu Asp Glu Ala Gln 
 170                 175                 180

 tcacattgtt cttttatata tatttatata tatatataaa aattgggtct tagattttga    701

 tttactagtg tgacaaaata actacatcct aatgaaaatc aagtttgata tgtttgtttt    761

 gaaagtagcg ttggaagagt tgttgggggt tttttgcatc catagcactg gttactttga    821

 acaaataaat aaaagctttc tgtagttgct tcctttatca gaaaaaaaaa aaa           874




      <210> 96
      <211> 1553
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (83)..(1198)

      <400> 96
 gcacgaggtc ccgccgccgc ccgctgcgtc cgcccagcgc cactccgcgt cccgaccggc     60

 ccgcggcagc ctgcgccgcg cc atg gcc acc tcc ccg cag aag tcg cct tct     112
                          Met Ala Thr Ser Pro Gln Lys Ser Pro Ser
                            1               5                  10

 gtc ccc aag tct ccc act ccc aag tcg ccc ccg tcc cgc aag aaa gat      160
 Val Pro Lys Ser Pro Thr Pro Lys Ser Pro Pro Ser Arg Lys Lys Asp
                  15                  20                  25

 gat tcc ttc ttg ggg aaa ctc gga ggg acc ctg gcc cgg agg aag aaa      208
 Asp Ser Phe Leu Gly Lys Leu Gly Gly Thr Leu Ala Arg Arg Lys Lys
              30                  35                  40

 gcc aag gag gtg tcc gag ctg cag gag gag gga atg aac gcc atc aac      256
 Ala Lys Glu Val Ser Glu Leu Gln Glu Glu Gly Met Asn Ala Ile Asn
          45                  50                  55

 ctg ccc ctc agc cca att ccc ttt gag ctg gac ccc gag gac acg atg      304
 Leu Pro Leu Ser Pro Ile Pro Phe Glu Leu Asp Pro Glu Asp Thr Met
      60                  65                  70

 ctg gag gag aat gag gtg cga aca atg gtg gat cca aac tca cgc agt      352
 Leu Glu Glu Asn Glu Val Arg Thr Met Val Asp Pro Asn Ser Arg Ser
  75                  80                  85                  90

 gac ccc aag ctt caa gaa ctg atg aag gta tta att gac tgg att aat      400
 Asp Pro Lys Leu Gln Glu Leu Met Lys Val Leu Ile Asp Trp Ile Asn
                  95                 100                 105

 gat gtg ttg gtt gga gaa aga atc att gtg aaa gac cta gct gaa gat      448
 Asp Val Leu Val Gly Glu Arg Ile Ile Val Lys Asp Leu Ala Glu Asp
             110                 115                 120

 ttg tat gat gga caa gtc ctg cag aag ctt ttc gag aaa ctg gag agt      496
 Leu Tyr Asp Gly Gln Val Leu Gln Lys Leu Phe Glu Lys Leu Glu Ser
         125                 130                 135

 gag aag cta aat gtg gct gag gtc acc cag tca gag att gct cag aag      544
 Glu Lys Leu Asn Val Ala Glu Val Thr Gln Ser Glu Ile Ala Gln Lys
     140                 145                 150

 caa aaa ctg cag act gtc ctg gag aag atc aat gaa acc ctg aaa ctt      592
 Gln Lys Leu Gln Thr Val Leu Glu Lys Ile Asn Glu Thr Leu Lys Leu
 155                 160                 165                 170

 cct ccc agg agc atc aag tgg aat gtg gat tct gtt cat gcc aag agc      640
 Pro Pro Arg Ser Ile Lys Trp Asn Val Asp Ser Val His Ala Lys Ser
                 175                 180                 185

 ctg gtg gcc atc tta cac ctg ctc gtt gct ctg tct cag tat ttc cgt      688
 Leu Val Ala Ile Leu His Leu Leu Val Ala Leu Ser Gln Tyr Phe Arg
             190                 195                 200

 gca cca att cga ctc cca gac cat gtt tcc atc caa gtg gtt gtg gtc      736
 Ala Pro Ile Arg Leu Pro Asp His Val Ser Ile Gln Val Val Val Val
         205                 210                 215

 cag aaa cga gaa gga atc ctc cag tct cgg caa atc caa gag gaa ata      784
 Gln Lys Arg Glu Gly Ile Leu Gln Ser Arg Gln Ile Gln Glu Glu Ile
     220                 225                 230

 act ggt aac aca gag gct ctt tcc ggg agg cat gaa cgt gat gcc ttt      832
 Thr Gly Asn Thr Glu Ala Leu Ser Gly Arg His Glu Arg Asp Ala Phe
 235                 240                 245                 250

 gac acc ttg ttc gac cat gcc cca gac aag ctg aat gtg gtg aaa aag      880
 Asp Thr Leu Phe Asp His Ala Pro Asp Lys Leu Asn Val Val Lys Lys
                 255                 260                 265

 aca ctc atc act ttc gtg aac aag cac ctg aat aaa ctg aac ctg gag      928
 Thr Leu Ile Thr Phe Val Asn Lys His Leu Asn Lys Leu Asn Leu Glu
             270                 275                 280

 gtc aca gaa ctg gaa acc cag ttt gca gat ggg gtg tac ctg gtg ctg      976
 Val Thr Glu Leu Glu Thr Gln Phe Ala Asp Gly Val Tyr Leu Val Leu
         285                 290                 295

 ctc atg ggg ctc ctg gag ggc tac ttt gtg ccc ctg cac agc ttc ttc     1024
 Leu Met Gly Leu Leu Glu Gly Tyr Phe Val Pro Leu His Ser Phe Phe
     300                 305                 310

 ctg acc ccg gac agc ttt gaa cag aag gtc ttg aat gtc tcc ttt gcc     1072
 Leu Thr Pro Asp Ser Phe Glu Gln Lys Val Leu Asn Val Ser Phe Ala
 315                 320                 325                 330

 ttt gag ctc atg caa gat gga ggg ttg gaa aag cca aaa ccg cgg cca     1120
 Phe Glu Leu Met Gln Asp Gly Gly Leu Glu Lys Pro Lys Pro Arg Pro
                 335                 340                 345

 gaa gac ata gtc aac tgt gac ctg aaa tct aca cta cga gtg ttg tac     1168
 Glu Asp Ile Val Asn Cys Asp Leu Lys Ser Thr Leu Arg Val Leu Tyr
             350                 355                 360

 aac ctc ttc acc aag tac cgt aac gtg gag t gaggggctgc cctgggccca     1219
 Asn Leu Phe Thr Lys Tyr Arg Asn Val Glu 
         365                 370

 ccactgccca agagttcttg ctgttggcgt actggaccct cctccgaact gccttaccct   1279

 gcttattcct gtctcttgca ctgtgctctc ccacaagtcc agctgcaacc cagagatagt   1339

 ggaaactgaa attaggaagg aaatcatcaa taactcagtg ggctgaccca tccctcccag   1399

 gcgctgggga ccaacctagc aatgaaggtt gggaaggttg ttcccttccc ggtgccaggt   1459

 ccagatttcc ctccatgatt tgggaaccag cttaggcaaa agagtcccca caagatgaaa   1519

 ataaagatcc tagttaccat tcaaaaaaaa aaaa                               1553




      <210> 97
      <211> 883
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (164)..(808)

      <400> 97
 attgaacgcc tgcggaattc gtacgaggct ctctctctct ctctctctct ctctctctcc     60

 tgaggctgct ccagcagggc gccgccgccg tctcctgggg cggcttgggg tagccgggag    120

 atcctgtgcc ttcaaaccct acgagtccat actttaaaac aaa  atg aag aaa gta     175
                                                  Met Lys Lys Val
                                                    1

 agg ctt aag gaa cta gag agt cgc ctg caa caa gtg gat gga ttt gaa      223
 Arg Leu Lys Glu Leu Glu Ser Arg Leu Gln Gln Val Asp Gly Phe Glu
   5                  10                  15                  20

 aag ccc aag cta ctt ctg gaa cag tat cct acc agg ccg cac att gca      271
 Lys Pro Lys Leu Leu Leu Glu Gln Tyr Pro Thr Arg Pro His Ile Ala
                  25                  30                  35

 gca tgt atg ctc tat aca atc cat aac act tat gat gac att gaa aat      319
 Ala Cys Met Leu Tyr Thr Ile His Asn Thr Tyr Asp Asp Ile Glu Asn
              40                  45                  50

 aaa gtc gtt gca gat cta gga tgt ggt tgt gga gta ctt agc atc gga      367
 Lys Val Val Ala Asp Leu Gly Cys Gly Cys Gly Val Leu Ser Ile Gly
          55                  60                  65

 act gca atg tta gga gca ggg ttg tgt gtt gga ttt gac ata gat gaa      415
 Thr Ala Met Leu Gly Ala Gly Leu Cys Val Gly Phe Asp Ile Asp Glu
      70                  75                  80

 gac gca ttg gaa ata ttt aat agg aat gca gaa gag ttt gag tta aca      463
 Asp Ala Leu Glu Ile Phe Asn Arg Asn Ala Glu Glu Phe Glu Leu Thr
  85                  90                  95                 100

 aat att gac atg gtt caa tgt gat gtg tgc tta tta tct aac aga atg      511
 Asn Ile Asp Met Val Gln Cys Asp Val Cys Leu Leu Ser Asn Arg Met
                 105                 110                 115

 tcc aag tca ttc gat aca gta att atg aat cct ccc ttt ggg acc aaa      559
 Ser Lys Ser Phe Asp Thr Val Ile Met Asn Pro Pro Phe Gly Thr Lys
             120                 125                 130

 aat aat aaa ggg aca gat atg gct ttt cta aag act gct ttg gaa atg      607
 Asn Asn Lys Gly Thr Asp Met Ala Phe Leu Lys Thr Ala Leu Glu Met
         135                 140                 145

 gca aga aca gca gta tat tcc tta cac aaa tcc tca act aga gaa cat      655
 Ala Arg Thr Ala Val Tyr Ser Leu His Lys Ser Ser Thr Arg Glu His
     150                 155                 160

 gtt caa aag aaa gct gca gaa tgg aaa atc aag ata gat att ata gca      703
 Val Gln Lys Lys Ala Ala Glu Trp Lys Ile Lys Ile Asp Ile Ile Ala
 165                 170                 175                 180

 ggt ggc ttt tgt ttt aca gaa ctt cga tat gac ctg cca gca tca tac      751
 Gly Gly Phe Cys Phe Thr Glu Leu Arg Tyr Asp Leu Pro Ala Ser Tyr
                 185                 190                 195

 aag ttt cac aaa aag aaa tca gtg gac att gaa gtg gac cta att cgg      799
 Lys Phe His Lys Lys Lys Ser Val Asp Ile Glu Val Asp Leu Ile Arg
             200                 205                 210

 ttt tcc ttt taaaagc cccgcaaaca aaagtcgttt aaaacctatt taaaatgaat      855
 Phe Ser Phe 
         215

 aaaaaattgg tttactaaaa aaaaaaaa                                       883




      <210> 98
      <211> 812
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (67)..(507)

      <400> 98
 gagcgcaccc ggccggaagc cgctgtcggg gagccggcgg tggggctgga cgcaggtgca     60

 actgac   atg ggt gaa ccc cag gga tcc atg cgg att cta gtg aca ggg     108
          Met Gly Glu Pro Gln Gly Ser Met Arg Ile Leu Val Thr Gly
            1               5                  10

 ggc tct ggg ctg gta ggc aaa gcc atc cag aag gtg gta gca gat gga      156
 Gly Ser Gly Leu Val Gly Lys Ala Ile Gln Lys Val Val Ala Asp Gly
  15                  20                  25                  30

 gct gga ctt cct gga gag gac tgg gtg ttt gtc tcc tct aaa gac gcc      204
 Ala Gly Leu Pro Gly Glu Asp Trp Val Phe Val Ser Ser Lys Asp Ala
                  35                  40                  45

 gat ctc acg gat aca gca cag acc cgc gcc ctg ttt gag aag gtc caa      252
 Asp Leu Thr Asp Thr Ala Gln Thr Arg Ala Leu Phe Glu Lys Val Gln
              50                  55                  60

 ccc aca cac atc atc ctc tcc gtg ggc gag gaa gat gag gtc tcc atc      300
 Pro Thr His Ile Ile Leu Ser Val Gly Glu Glu Asp Glu Val Ser Ile
          65                  70                  75

 aag gag gca gcc gag gcg gtg gtg gag gcc atg gac ttc cat ggg gaa      348
 Lys Glu Ala Ala Glu Ala Val Val Glu Ala Met Asp Phe His Gly Glu
      80                  85                  90

 gtc acc ttt gat aca acc aag tcg gat ggg cag ttt aag aag aca gcc      396
 Val Thr Phe Asp Thr Thr Lys Ser Asp Gly Gln Phe Lys Lys Thr Ala
  95                 100                 105                 110

 agt aac agc aag ctg agg acc tac ctg ccc gac ttc cgg ttc aca ccc      444
 Ser Asn Ser Lys Leu Arg Thr Tyr Leu Pro Asp Phe Arg Phe Thr Pro
                 115                 120                 125

 ttc aag cag gcg gtg aag gag acc tgt gct tgg ttc act gac aac tac      492
 Phe Lys Gln Ala Val Lys Glu Thr Cys Ala Trp Phe Thr Asp Asn Tyr
             130                 135                 140

 gag cag gcc cgg aag tgaagctgga agacaggatc aggtgccagc ggaccatcgg      547
 Glu Gln Ala Arg Lys 
         145

 ctggcagagc ccagcggcca ccacccgtca accctgccag gagctgaggg caccacccag    607

 caacctgggc ctgcattcca tccgctctgc agccccaagc atctttccag tggggccccc    667

 attcacgttg gtcctcaggg aaaccagggt ccggggcagg cccggcgctt tgctccccac    727

 accagccccc tgcgcgtgtc cactctgatc ctgcatccca ctccctggga gccaataaag    787

 tgcattttca cagaaaaaaa aaaaa                                          812




      <210> 99
      <211> 3479
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (201)..(2543)

      <400> 99
 gtggcagcag cgttggcccg gccccgggag cggagagcga ggggaggcgg agacggagga     60

 aggtctgagg agcagcttca gtccccgccg agccgccacc gcaggtcgag gacggtcgga    120

 ctcccgcggc gggaggagcc tgttcccctg agggtatttg aagtatacca tacaactgtt    180

 ttgaaaatcc agcgtggaca    atg gct act caa gct gat ttg atg gag ttg     230
                          Met Ala Thr Gln Ala Asp Leu Met Glu Leu
                            1               5                  10

 gac atg gcc atg gaa cca gac aga aaa gcg gct gtt agt cac tgg cag      278
 Asp Met Ala Met Glu Pro Asp Arg Lys Ala Ala Val Ser His Trp Gln
                  15                  20                  25

 caa cag tct tac ctg gac tct gga atc cat tct ggt gcc act acc aca      326
 Gln Gln Ser Tyr Leu Asp Ser Gly Ile His Ser Gly Ala Thr Thr Thr
              30                  35                  40

 gct cct tct ctg agt ggt aaa ggc aat cct gag gaa gag gat gtg gat      374
 Ala Pro Ser Leu Ser Gly Lys Gly Asn Pro Glu Glu Glu Asp Val Asp
          45                  50                  55

 acc tcc caa gtc ctg tat gag tgg gaa cag gga ttt tct cag tcc ttc      422
 Thr Ser Gln Val Leu Tyr Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe
      60                  65                  70

 act caa gaa caa gta gct gat att gat gga cag tat gca atg act cga      470
 Thr Gln Glu Gln Val Ala Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg
  75                  80                  85                  90

 gct cag agg gta cga gct gct atg ttc cct gag aca tta gat gag ggc      518
 Ala Gln Arg Val Arg Ala Ala Met Phe Pro Glu Thr Leu Asp Glu Gly
                  95                 100                 105

 atg cag atc cca tct aca cag ttt gat gct gct cat ccc act aat gtc      566
 Met Gln Ile Pro Ser Thr Gln Phe Asp Ala Ala His Pro Thr Asn Val
             110                 115                 120

 cag cgt ttg gct gaa cca tca cag atg ctg aaa cat gca gtt gta aac      614
 Gln Arg Leu Ala Glu Pro Ser Gln Met Leu Lys His Ala Val Val Asn
         125                 130                 135

 ttg att aac tat caa gat gat gca gaa ctt gcc aca cgt gca atc cct      662
 Leu Ile Asn Tyr Gln Asp Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro
     140                 145                 150

 gaa ctg aca aaa ctg cta aat gac gag gac cag gtg gtg gtt aat aag      710
 Glu Leu Thr Lys Leu Leu Asn Asp Glu Asp Gln Val Val Val Asn Lys
 155                 160                 165                 170

 gct gca gtt atg gtc cat cag ctt tct aaa aag gaa gct tcc aga cac      758
 Ala Ala Val Met Val His Gln Leu Ser Lys Lys Glu Ala Ser Arg His
                 175                 180                 185

 gct atc atg cgt tct cct cag atg gtg tct gct att gta cgt acc atg      806
 Ala Ile Met Arg Ser Pro Gln Met Val Ser Ala Ile Val Arg Thr Met
             190                 195                 200

 cag aat aca aat gat gta gaa aca gct cgt tgt acc gct ggg acc ttg      854
 Gln Asn Thr Asn Asp Val Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu
         205                 210                 215

 cat aac ctt tcc cat cat cgt gag ggc tta ctg gcc atc ttt aag tct      902
 His Asn Leu Ser His His Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser
     220                 225                 230

 gga ggc att cct gcc ctg gtg aaa atg ctt ggt tca cca gtg gat tct      950
 Gly Gly Ile Pro Ala Leu Val Lys Met Leu Gly Ser Pro Val Asp Ser
 235                 240                 245                 250

 gtg ttg ttt tat gcc att aca act ctc cac aac ctt tta tta cat caa      998
 Val Leu Phe Tyr Ala Ile Thr Thr Leu His Asn Leu Leu Leu His Gln
                 255                 260                 265

 gaa gga gct aaa atg gca gtg cgt tta gct ggt ggg ctg cag aaa atg     1046
 Glu Gly Ala Lys Met Ala Val Arg Leu Ala Gly Gly Leu Gln Lys Met
             270                 275                 280

 gtt gcc ttg ctc aac aaa aca aat gtt aaa ttc ttg gct att acg aca     1094
 Val Ala Leu Leu Asn Lys Thr Asn Val Lys Phe Leu Ala Ile Thr Thr
         285                 290                 295

 gac tgc ctt caa att tta gct tat ggc aac caa gaa agc aag ctc atc     1142
 Asp Cys Leu Gln Ile Leu Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile
     300                 305                 310

 ata ctg gct agt ggt gga ccc caa gct tta gta aat ata atg agg acc     1190
 Ile Leu Ala Ser Gly Gly Pro Gln Ala Leu Val Asn Ile Met Arg Thr
 315                 320                 325                 330

 tat act tac gaa aaa cta ctg tgg acc aca agc aga gtg ctg aag gtg     1238
 Tyr Thr Tyr Glu Lys Leu Leu Trp Thr Thr Ser Arg Val Leu Lys Val
                 335                 340                 345

 cta tct gtc tgc tct agt aat aag ccg gct att gta gaa gct ggt gga     1286
 Leu Ser Val Cys Ser Ser Asn Lys Pro Ala Ile Val Glu Ala Gly Gly
             350                 355                 360

 atg caa gct tta gga ctt cac ctg aca gat cca agt caa cgt ctt gtt     1334
 Met Gln Ala Leu Gly Leu His Leu Thr Asp Pro Ser Gln Arg Leu Val
         365                 370                 375

 cag aac tgt ctt tgg act ctc agg aat ctt tca gat gct gca act aaa     1382
 Gln Asn Cys Leu Trp Thr Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys
     380                 385                 390

 cag gaa ggg atg gaa ggt ctc ctt ggg act ctt gtt cag ctt ctg ggt     1430
 Gln Glu Gly Met Glu Gly Leu Leu Gly Thr Leu Val Gln Leu Leu Gly
 395                 400                 405                 410

 tca gat gat ata aat gtg gtc acc tgt gca gct gga att ctt tct aac     1478
 Ser Asp Asp Ile Asn Val Val Thr Cys Ala Ala Gly Ile Leu Ser Asn
                 415                 420                 425

 ctc act tgc aat aat tat aag aac aag atg atg gtc tgc caa gtg ggt     1526
 Leu Thr Cys Asn Asn Tyr Lys Asn Lys Met Met Val Cys Gln Val Gly
             430                 435                 440

 ggt ata gag gct ctt gtg cgt act gtc ctt cgg gct ggt gac agg gaa     1574
 Gly Ile Glu Ala Leu Val Arg Thr Val Leu Arg Ala Gly Asp Arg Glu
         445                 450                 455

 gac atc act gag cct gcc atc tgt gct ctt cgt cat ctg acc agc cga     1622
 Asp Ile Thr Glu Pro Ala Ile Cys Ala Leu Arg His Leu Thr Ser Arg
     460                 465                 470

 cac caa gaa gca gag atg gcc cag aat gca gtt cgc ctt cac tat gga     1670
 His Gln Glu Ala Glu Met Ala Gln Asn Ala Val Arg Leu His Tyr Gly
 475                 480                 485                 490

 cta cca gtt gtg gtt aag ctc tta cac cca cca tcc cac tgg cct ctg     1718
 Leu Pro Val Val Val Lys Leu Leu His Pro Pro Ser His Trp Pro Leu
                 495                 500                 505

 ata aag gct act gtt gga ttg att cga aat ctt gcc ctt tgt ccc gca     1766
 Ile Lys Ala Thr Val Gly Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala
             510                 515                 520

 aat cat gca cct ttg cgt gag cag ggt gcc att cca cga cta gtt cag     1814
 Asn His Ala Pro Leu Arg Glu Gln Gly Ala Ile Pro Arg Leu Val Gln
         525                 530                 535

 ttg ctt gtt cgt gca cat cag gat acc cag cgc cgt acg tcc atg ggt     1862
 Leu Leu Val Arg Ala His Gln Asp Thr Gln Arg Arg Thr Ser Met Gly
     540                 545                 550

 ggg aca cag cag caa ttt gtg gag ggg gtc cgc atg gaa gaa ata gtt     1910
 Gly Thr Gln Gln Gln Phe Val Glu Gly Val Arg Met Glu Glu Ile Val
 555                 560                 565                 570

 gaa ggt tgt acc gga gcc ctt cac atc cta gct cgg gat gtt cac aac     1958
 Glu Gly Cys Thr Gly Ala Leu His Ile Leu Ala Arg Asp Val His Asn
                 575                 580                 585

 cga att gtt atc aga gga cta aat acc att cca ttg ttt gtg cag ctg     2006
 Arg Ile Val Ile Arg Gly Leu Asn Thr Ile Pro Leu Phe Val Gln Leu
             590                 595                 600

 ctt tat tct ccc att gaa aac atc caa aga gta gct gca ggg gtc ctc     2054
 Leu Tyr Ser Pro Ile Glu Asn Ile Gln Arg Val Ala Ala Gly Val Leu
         605                 610                 615

 tgt gaa ctt gct cag gac aag gaa gct gca gaa gct att gaa gct gag     2102
 Cys Glu Leu Ala Gln Asp Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu
     620                 625                 630

 gga gcc aca gct cct ctg aca gag tta ctt cac tct agg aat gaa ggt     2150
 Gly Ala Thr Ala Pro Leu Thr Glu Leu Leu His Ser Arg Asn Glu Gly
 635                 640                 645                 650

 gtg gcg aca tat gca gct gct gtt ttg ttc cga atg tct gag gac aag     2198
 Val Ala Thr Tyr Ala Ala Ala Val Leu Phe Arg Met Ser Glu Asp Lys
                 655                 660                 665

 cca caa gat tac aag aaa cgg ctt tca gtt gag ctg acc agc tct ctc     2246
 Pro Gln Asp Tyr Lys Lys Arg Leu Ser Val Glu Leu Thr Ser Ser Leu
             670                 675                 680

 ttc aga aca gag cca atg gct tgg aat gag act gct gat ctt gga ctt     2294
 Phe Arg Thr Glu Pro Met Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu
         685                 690                 695

 gat att ggt gcc cag gga gaa ccc ctt gga tat cgc cag gat gat cct     2342
 Asp Ile Gly Ala Gln Gly Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro
     700                 705                 710

 agc tat cgt tct ttt cac tct ggt gga tat ggc cag gat gcc ttg ggt     2390
 Ser Tyr Arg Ser Phe His Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly
 715                 720                 725                 730

 atg gac ccc atg atg gaa cat gag atg ggt ggc cac cac cct ggt gct     2438
 Met Asp Pro Met Met Glu His Glu Met Gly Gly His His Pro Gly Ala
                 735                 740                 745

 gac tat cca gtt gat ggg ctg cca gat ctg ggg cat gcc cag gac ctc     2486
 Asp Tyr Pro Val Asp Gly Leu Pro Asp Leu Gly His Ala Gln Asp Leu
             750                 755                 760

 atg gat ggg ctg cct cca ggt gac agc aat cag ctg gcc tgg ttt gat     2534
 Met Asp Gly Leu Pro Pro Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp
         765                 770                 775

 act gac ctg taaatca tcctttagga gtaacaatac aaatggattt tgggagtgac     2590
 Thr Asp Leu 
     780

 tcaagaagtg aagaatgcac aagaatggat cacaagatgg aatttatcaa accctaacct   2650

 tgcttggtta aatttttttt tttttttttt taagaatatc tgtaatggta ctgactttgc   2710

 ttgctttgaa gtagctcttt tttttttttt tttttttttg cagtaactgt tttttaagtc   2770

 tctcgtagtg ttaagttata gtgaatactg ctacagcaat ttctaatttt taagaattga   2830

 gtaatggtgt agaacactaa ttcataatca ctctaattaa ttgtaatctg aataaagtgt   2890

 aacaattgtg tagccttttt gtataaaata gacaaataga aaatggtcca attagtttcc   2950

 tttttaatat gcttaaaata agcaggtgga tctatttcat gtttttgatc aaaaactatt   3010

 tgggatatgt atgggtaggg taaatcagta agaggtgtta tttggaacct tgttttggac   3070

 agtttaccag ttgcctttta tcccaaagtt gttgtaacct gctgtgatac gatgcttcaa   3130

 gagaaaatgc ggttataaaa aatggttcag aattaaactt ttaattcatt cgattgtgtc   3190

 actctttctt tttttcttgt cattaataaa tggtttgtga gggtggtaag taagtttatc   3250

 caactcaact ttatcctgaa ctttatcctg agatagatag atacatagtg aagtaatttg   3310

 ttgtagcgat agagagggcc ctacttctct agatgcaatt tgccaagttt ctttagcatt   3370

 tggccctgga ttacgctgga cccctaaaaa agtgtttcag ccttgcacat tgtgattagt   3430

 tctgggcttt ggtgggagaa agccaagcag actatccatc tatctctac               3479




      <210> 100
      <211> 3766
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (259)..(3711)

      <400> 100
 cctttcctgt tctgattggt tgcttacgtg agcgtgacta ctttcttgcc tcatgattgg     60

 ctgaaatcag tagcgtcatc ggcggccggg agggcggagg gacgagggaa gtcggcgaga    120

 gggagactgg gttgggggag gggttcaggc ctgttccccg cggctgcggc agcaccaggg    180

 ccggccgcca ccgcctctag aacgcggagg aggtgggtcc tgggaagcgg gatgtccatc    240

 gctccagctt ggtggtga  atg ctg agg aga gtc act gtt gct gca gtc tgt     291
                      Met Leu Arg Arg Val Thr Val Ala Ala Val Cys
                        1               5                  10

 gcc acc cgg agg aag ttg tgt gag gcc ggg cgg gag ctc gcg gcg ctc      339
 Ala Thr Arg Arg Lys Leu Cys Glu Ala Gly Arg Glu Leu Ala Ala Leu
              15                  20                  25

 tgg gga atc gaa acg cgg ggt cgg tgc gaa gac tct gct gct gcc aga      387
 Trp Gly Ile Glu Thr Arg Gly Arg Cys Glu Asp Ser Ala Ala Ala Arg
          30                  35                  40

 ccc ttt cct att ctg gcc atg cct gga agg aac aag gcg aag tct acc      435
 Pro Phe Pro Ile Leu Ala Met Pro Gly Arg Asn Lys Ala Lys Ser Thr
      45                  50                  55

 tgc agc tgc cct gac ctg cag ccc aat gga cag gat ctg ggc gag aac      483
 Cys Ser Cys Pro Asp Leu Gln Pro Asn Gly Gln Asp Leu Gly Glu Asn
  60                  65                  70                  75

 agc cgg gtt gcc cgt cta gga gcg gat gaa tct gag gaa gag gga cgg      531
 Ser Arg Val Ala Arg Leu Gly Ala Asp Glu Ser Glu Glu Glu Gly Arg
                  80                  85                  90

 agg ggg tct ctc agt aat gct ggg gac cct gag atc gtc aag tct ccc      579
 Arg Gly Ser Leu Ser Asn Ala Gly Asp Pro Glu Ile Val Lys Ser Pro
              95                 100                 105

 agc gac ccc aag caa tac cga tac atc aaa tta cag aat ggc ttg cag      627
 Ser Asp Pro Lys Gln Tyr Arg Tyr Ile Lys Leu Gln Asn Gly Leu Gln
         110                 115                 120

 gca ctt ctg att tca gac cta agt aat atg gaa ggt aaa aca gga aat      675
 Ala Leu Leu Ile Ser Asp Leu Ser Asn Met Glu Gly Lys Thr Gly Asn
     125                 130                 135

 aca aca gat gat gaa gaa gaa gag gag gtg gag gaa gaa gaa gaa gat      723
 Thr Thr Asp Asp Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Asp
 140                 145                 150                 155

 gat gat gaa gat tct gga gct gaa ata gaa gat gac gat gaa gag ggt      771
 Asp Asp Glu Asp Ser Gly Ala Glu Ile Glu Asp Asp Asp Glu Glu Gly
                 160                 165                 170

 ttt gat gat gaa gat gag ttt gat gat gaa cat gat gat gat ctt gat      819
 Phe Asp Asp Glu Asp Glu Phe Asp Asp Glu His Asp Asp Asp Leu Asp
             175                 180                 185

 act gag gat aat gaa ttg gaa gaa tta gaa gag aga gca gaa gct aga      867
 Thr Glu Asp Asn Glu Leu Glu Glu Leu Glu Glu Arg Ala Glu Ala Arg
         190                 195                 200

 aaa aaa act act gaa aaa cag tct gca gcg gct ctt tgt gtt gga gtt      915
 Lys Lys Thr Thr Glu Lys Gln Ser Ala Ala Ala Leu Cys Val Gly Val
     205                 210                 215

 ggg agt ttc gct gat cca gat gac ctg ccg ggg ctg gca cac ttt ttg      963
 Gly Ser Phe Ala Asp Pro Asp Asp Leu Pro Gly Leu Ala His Phe Leu
 220                 225                 230                 235

 gag cac atg gta ttc atg ggt agt ttg aaa tat cca gat gag aat gga     1011
 Glu His Met Val Phe Met Gly Ser Leu Lys Tyr Pro Asp Glu Asn Gly
                 240                 245                 250

 ttt gat gcc ttc ctg aag aag cat ggg ggt agt gat aat gcc tca act     1059
 Phe Asp Ala Phe Leu Lys Lys His Gly Gly Ser Asp Asn Ala Ser Thr
             255                 260                 265

 gat tgt gaa cgc act gtc ttt cag ttt gat gtc cag agg aag tac ttc     1107
 Asp Cys Glu Arg Thr Val Phe Gln Phe Asp Val Gln Arg Lys Tyr Phe
         270                 275                 280

 aag gaa gct ctt gat aga tgg gcg cag ttc ttc atc cac cca cta atg     1155
 Lys Glu Ala Leu Asp Arg Trp Ala Gln Phe Phe Ile His Pro Leu Met
     285                 290                 295

 atc aga gat gca att gac cgt gaa gtt gaa gct gtt gat agt gaa tat     1203
 Ile Arg Asp Ala Ile Asp Arg Glu Val Glu Ala Val Asp Ser Glu Tyr
 300                 305                 310                 315

 caa ctt gca agg cct tct gat gca aac aga aag gaa atg ttg ttt gga     1251
 Gln Leu Ala Arg Pro Ser Asp Ala Asn Arg Lys Glu Met Leu Phe Gly
                 320                 325                 330

 agc ctt gct aga cct gga cat cct atg gga aaa ttt ttt tgg gga aat     1299
 Ser Leu Ala Arg Pro Gly His Pro Met Gly Lys Phe Phe Trp Gly Asn
             335                 340                 345

 gct gag acg ctc aag cat gag cca aga aag aat aat att gat aca cat     1347
 Ala Glu Thr Leu Lys His Glu Pro Arg Lys Asn Asn Ile Asp Thr His
         350                 355                 360

 gct aga ttg aga gaa ttc tgg atg cgt tac tac tct tct cat tac atg     1395
 Ala Arg Leu Arg Glu Phe Trp Met Arg Tyr Tyr Ser Ser His Tyr Met
     365                 370                 375

 act tta gtg gtt caa tcc aaa gaa aca ctg gat act ttg gaa aag tgg     1443
 Thr Leu Val Val Gln Ser Lys Glu Thr Leu Asp Thr Leu Glu Lys Trp
 380                 385                 390                 395

 gtg act gaa atc ttc tct cag ata cca aac aat ggg tta ccc aga cca     1491
 Val Thr Glu Ile Phe Ser Gln Ile Pro Asn Asn Gly Leu Pro Arg Pro
                 400                 405                 410

 aac ttt ggc cat tta acg gat cca ttt gac aca cca gca ttt aac aaa     1539
 Asn Phe Gly His Leu Thr Asp Pro Phe Asp Thr Pro Ala Phe Asn Lys
             415                 420                 425

 ctt tat aga gtt gtt cca atc aga aaa att cat gct ctg acc atc aca     1587
 Leu Tyr Arg Val Val Pro Ile Arg Lys Ile His Ala Leu Thr Ile Thr
         430                 435                 440

 tgg gca ctt cct cct caa cag caa cat tac agg gtg aag cca ctt cat     1635
 Trp Ala Leu Pro Pro Gln Gln Gln His Tyr Arg Val Lys Pro Leu His
     445                 450                 455

 tat ata tcc tgg ctg gtt gga cat gaa ggc aaa ggc agc att ctt tct     1683
 Tyr Ile Ser Trp Leu Val Gly His Glu Gly Lys Gly Ser Ile Leu Ser
 460                 465                 470                 475

 ttc ctt agg aaa aaa tgc tgg gct ctt gca ctg ttt ggt gga aat ggt     1731
 Phe Leu Arg Lys Lys Cys Trp Ala Leu Ala Leu Phe Gly Gly Asn Gly
                 480                 485                 490

 gag aca gga ttt gag caa aat tct act tat tca gtg ttc agc att tct     1779
 Glu Thr Gly Phe Glu Gln Asn Ser Thr Tyr Ser Val Phe Ser Ile Ser
             495                 500                 505

 att aca ttg act gat gag ggt tat gaa cat ttt tat gag gtt gct tac     1827
 Ile Thr Leu Thr Asp Glu Gly Tyr Glu His Phe Tyr Glu Val Ala Tyr
         510                 515                 520

 act gtc ttt cag tat tta aaa atg ctg cag aag cta ggc cca gaa aaa     1875
 Thr Val Phe Gln Tyr Leu Lys Met Leu Gln Lys Leu Gly Pro Glu Lys
     525                 530                 535

 aga att ttt gaa gag att cgg aaa att gag gat aat gaa ttt cat tac     1923
 Arg Ile Phe Glu Glu Ile Arg Lys Ile Glu Asp Asn Glu Phe His Tyr
 540                 545                 550                 555

 caa gaa cag aca gat cca gtt gag tat gtg gaa aac atg tgt gag aac     1971
 Gln Glu Gln Thr Asp Pro Val Glu Tyr Val Glu Asn Met Cys Glu Asn
                 560                 565                 570

 atg cag ctg tac cca ttg cag gac att ctc act gga gat cag ctt ctt     2019
 Met Gln Leu Tyr Pro Leu Gln Asp Ile Leu Thr Gly Asp Gln Leu Leu
             575                 580                 585

 ttt gaa tac aag cca gaa gtc att ggt gaa gcc ttg aat cag cta gtt     2067
 Phe Glu Tyr Lys Pro Glu Val Ile Gly Glu Ala Leu Asn Gln Leu Val
         590                 595                 600

 cct caa aaa gca aat ctt gtt tta ctg tct ggt gct aat gag gga aaa     2115
 Pro Gln Lys Ala Asn Leu Val Leu Leu Ser Gly Ala Asn Glu Gly Lys
     605                 610                 615

 tgt gac ctc aag gag aaa tgg ttt gga act caa tat agt ata gaa gat     2163
 Cys Asp Leu Lys Glu Lys Trp Phe Gly Thr Gln Tyr Ser Ile Glu Asp
 620                 625                 630                 635

 att gaa aac tct tgg gct gaa ctg tgg aat agt aat ttc gaa tta aat     2211
 Ile Glu Asn Ser Trp Ala Glu Leu Trp Asn Ser Asn Phe Glu Leu Asn
                 640                 645                 650

 cca gat ctt cat ctt cca gct gaa aac aag tac ata gcc acg gac ttt     2259
 Pro Asp Leu His Leu Pro Ala Glu Asn Lys Tyr Ile Ala Thr Asp Phe
             655                 660                 665

 acg ttg aag gct ttc gat tgc ccg gaa aca gaa tac cca gtt aaa att     2307
 Thr Leu Lys Ala Phe Asp Cys Pro Glu Thr Glu Tyr Pro Val Lys Ile
         670                 675                 680

 gtg aat act cca caa ggt tgc ctg tgg tat aag aaa gac aac aaa ttc     2355
 Val Asn Thr Pro Gln Gly Cys Leu Trp Tyr Lys Lys Asp Asn Lys Phe
     685                 690                 695

 aaa atc ccc aaa gca tat ata cgt ttc cat cta att tca ccg ttg ata     2403
 Lys Ile Pro Lys Ala Tyr Ile Arg Phe His Leu Ile Ser Pro Leu Ile
 700                 705                 710                 715

 cag aaa tct gca gca aat gtg gtc ctc ttt gat atc ttt gtc aat atc     2451
 Gln Lys Ser Ala Ala Asn Val Val Leu Phe Asp Ile Phe Val Asn Ile
                 720                 725                 730

 ctt acg cat aac ctt gcg gaa cca gct tat gaa gca gat gtg gca cag     2499
 Leu Thr His Asn Leu Ala Glu Pro Ala Tyr Glu Ala Asp Val Ala Gln
             735                 740                 745

 ctg gag tat aaa ctg gta gct gga gaa cat ggt tta att att cga gtg     2547
 Leu Glu Tyr Lys Leu Val Ala Gly Glu His Gly Leu Ile Ile Arg Val
         750                 755                 760

 aaa gga ttt aac cac aaa cta cct cta ctg ttt cag ctc att att gac     2595
 Lys Gly Phe Asn His Lys Leu Pro Leu Leu Phe Gln Leu Ile Ile Asp
     765                 770                 775

 tac tta gct gag ttc aat tcc aca cca gct gtc ttt aca atg ata act     2643
 Tyr Leu Ala Glu Phe Asn Ser Thr Pro Ala Val Phe Thr Met Ile Thr
 780                 785                 790                 795

 gag cag ttg aag aag acc tac ttt aac atc ctc atc aag ccc gag act     2691
 Glu Gln Leu Lys Lys Thr Tyr Phe Asn Ile Leu Ile Lys Pro Glu Thr
                 800                 805                 810

 ttg gcc aaa gat gta cgg ctt tta atc ttg gaa tat gcc cgt tgg tct     2739
 Leu Ala Lys Asp Val Arg Leu Leu Ile Leu Glu Tyr Ala Arg Trp Ser
             815                 820                 825

 atg att gac aag tac cag gct ttg atg gac ggc ctt tcc ctt gag tct     2787
 Met Ile Asp Lys Tyr Gln Ala Leu Met Asp Gly Leu Ser Leu Glu Ser
         830                 835                 840

 ctg ctg agc ttc gtc aaa gaa ttc aaa tcc cag ctc ttt gtg gag ggc     2835
 Leu Leu Ser Phe Val Lys Glu Phe Lys Ser Gln Leu Phe Val Glu Gly
     845                 850                 855

 ctg gta caa ggg aat gtc aca agc aca gaa tct atg gat ttc ctg aaa     2883
 Leu Val Gln Gly Asn Val Thr Ser Thr Glu Ser Met Asp Phe Leu Lys
 860                 865                 870                 875

 tat gtt gtt gac aaa cta aac ttc aag cct ctg gag cag gag atg cct     2931
 Tyr Val Val Asp Lys Leu Asn Phe Lys Pro Leu Glu Gln Glu Met Pro
                 880                 885                 890

 gtg cag ttc cag gtg gta gag ctg ccc agt ggc cac cat cta tgc aaa     2979
 Val Gln Phe Gln Val Val Glu Leu Pro Ser Gly His His Leu Cys Lys
             895                 900                 905

 gtg aaa gct ctg aac aag ggt gat gcc aac tct gaa gtc act gtg tac     3027
 Val Lys Ala Leu Asn Lys Gly Asp Ala Asn Ser Glu Val Thr Val Tyr
         910                 915                 920

 tac cag tca ggt acc agg agt cta aga gaa tat acg ctt atg gag ctg     3075
 Tyr Gln Ser Gly Thr Arg Ser Leu Arg Glu Tyr Thr Leu Met Glu Leu
     925                 930                 935

 ctt gtg atg cac atg gaa gaa cct tgt ttt gac ttc ctt cga acc aag     3123
 Leu Val Met His Met Glu Glu Pro Cys Phe Asp Phe Leu Arg Thr Lys
 940                 945                 950                 955

 cag acc ctt ggg tac cat gtc tac cct acc tgt agg aac aca tcc ggg     3171
 Gln Thr Leu Gly Tyr His Val Tyr Pro Thr Cys Arg Asn Thr Ser Gly
                 960                 965                 970

 att cta gga ttt tct gtc act gtg ggg act cag gca acc aaa tac aat     3219
 Ile Leu Gly Phe Ser Val Thr Val Gly Thr Gln Ala Thr Lys Tyr Asn
             975                 980                 985

 tct gaa gtt gtt gat aag aag ata gaa gag ttt ctt tct agc ttt gag     3267
 Ser Glu Val Val Asp Lys Lys Ile Glu Glu Phe Leu Ser Ser Phe Glu
         990                 995                1000

 gag aag att gag aac ctc act gaa gag gca ttc aac acc cag gtc aca     3315
 Glu Lys Ile Glu Asn Leu Thr Glu Glu Ala Phe Asn Thr Gln Val Thr
    1005                1010                1015

 gct ctc atc aag ctg aag gag tgt gag gat acc cac ctt ggg gag gag     3363
 Ala Leu Ile Lys Leu Lys Glu Cys Glu Asp Thr His Leu Gly Glu Glu
1020                1025                1030                1035

 gtg gat agg aac tgg aat gaa gtg gtt aca cag cag tac ctc ttt gac     3411
 Val Asp Arg Asn Trp Asn Glu Val Val Thr Gln Gln Tyr Leu Phe Asp
                1040                1045                1050

 cgc ctt gcc cac gag att gaa gca ctg aag tca ttc tca aaa tca gac     3459
 Arg Leu Ala His Glu Ile Glu Ala Leu Lys Ser Phe Ser Lys Ser Asp
            1055                1060                1065

 ctg gtc aac tgg ttc aag gcc cat aga ggg cca gga agt aaa atg ctc     3507
 Leu Val Asn Trp Phe Lys Ala His Arg Gly Pro Gly Ser Lys Met Leu
        1070                1075                1080

 agc gtt cat gtt gtt gga tat ggg aag tat gaa ctg gaa gag gat ggt     3555
 Ser Val His Val Val Gly Tyr Gly Lys Tyr Glu Leu Glu Glu Asp Gly
    1085                1090                1095

 acc cct tct agt gag gat tca aat tct tct tgt gaa gtg atg cag ctg     3603
 Thr Pro Ser Ser Glu Asp Ser Asn Ser Ser Cys Glu Val Met Gln Leu
1100                1105                1110                1115

 acc tac ctg cca acc tct cct ctg ctg gca gat tgt atc atc ccc att     3651
 Thr Tyr Leu Pro Thr Ser Pro Leu Leu Ala Asp Cys Ile Ile Pro Ile
                1120                1125                1130

 act gat atc agg gct ttc aca aca aca ctc aac ctt ctc ccc tac cat     3699
 Thr Asp Ile Arg Ala Phe Thr Thr Thr Leu Asn Leu Leu Pro Tyr His
            1135                1140                1145

 aaa ata gtc aaa taa ataaactgca gtcacgttgg cctgaagcaa tgtgtatttt     3754
 Lys Ile Val Lys 
        1150

 aaaaaaaaaa aa                                                       3766




      <210> 101
      <211> 3970
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (259)..(3915)

      <400> 101
 cctttcctgt tctgattggt tgcttacgtg agcgtgacta ctttcttgcc tcatgattgg     60

 ctgaaatcag tagcgtcatc ggcggccggg agggcggagg gacgagggaa gtcggcgaga    120

 gggagactgg gttgggggag gggttcaggc ctgttccccg cggctgcggc agcaccaggg    180

 ccggccgcca ccgcctctag aacgcggagg aggtgggtcc tgggaagcgg gatgtccatc    240

 gctccagctt ggtggtga  atg ctg agg aga gtc act gtt gct gca gtc tgt     291
                      Met Leu Arg Arg Val Thr Val Ala Ala Val Cys
                        1               5                  10

 gcc acc cgg agg aag ttg tgt gag gcc ggg cgg gag ctc gcg gcg ctc      339
 Ala Thr Arg Arg Lys Leu Cys Glu Ala Gly Arg Glu Leu Ala Ala Leu
              15                  20                  25

 tgg gga atc gaa acg cgg ggt cgg tgc gaa gac tct gct gct gcc aga      387
 Trp Gly Ile Glu Thr Arg Gly Arg Cys Glu Asp Ser Ala Ala Ala Arg
          30                  35                  40

 ccc ttt cct att ctg gcc atg cct gga agg aac aag gcg aag tct acc      435
 Pro Phe Pro Ile Leu Ala Met Pro Gly Arg Asn Lys Ala Lys Ser Thr
      45                  50                  55

 tgc agc tgc cct gac ctg cag ccc aat gga cag gat ctg ggc gag aac      483
 Cys Ser Cys Pro Asp Leu Gln Pro Asn Gly Gln Asp Leu Gly Glu Asn
  60                  65                  70                  75

 agc cgg gtt gcc cgt cta gga gcg gat gaa tct gag gaa gag gga cgg      531
 Ser Arg Val Ala Arg Leu Gly Ala Asp Glu Ser Glu Glu Glu Gly Arg
                  80                  85                  90

 agg ggg tct ctc agt aat gct ggg gac cct gag atc gtc aag tct ccc      579
 Arg Gly Ser Leu Ser Asn Ala Gly Asp Pro Glu Ile Val Lys Ser Pro
              95                 100                 105

 agc gac ccc aag caa tac cga tac atc aaa tta cag aat ggc ttg cag      627
 Ser Asp Pro Lys Gln Tyr Arg Tyr Ile Lys Leu Gln Asn Gly Leu Gln
         110                 115                 120

 gca ctt ctg att tca gac cta agt aat atg gaa ggt aaa aca gga aat      675
 Ala Leu Leu Ile Ser Asp Leu Ser Asn Met Glu Gly Lys Thr Gly Asn
     125                 130                 135

 aca aca gat gat gaa gaa gaa gag gag gtg gag gaa gaa gaa gaa gat      723
 Thr Thr Asp Asp Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Asp
 140                 145                 150                 155

 gat gat gaa gat tct gga gct gaa ata gaa gat gac gat gaa gag ggt      771
 Asp Asp Glu Asp Ser Gly Ala Glu Ile Glu Asp Asp Asp Glu Glu Gly
                 160                 165                 170

 ttt gat gat gaa gat gag ttt gat gat gaa cat gat gat gat ctt gat      819
 Phe Asp Asp Glu Asp Glu Phe Asp Asp Glu His Asp Asp Asp Leu Asp
             175                 180                 185

 act gag gat aat gaa ttg gaa gaa tta gaa gag aga gca gaa gct aga      867
 Thr Glu Asp Asn Glu Leu Glu Glu Leu Glu Glu Arg Ala Glu Ala Arg
         190                 195                 200

 aaa aaa act act gaa aaa cag caa ttg cag agc ctg ttt ttg ctg tgg      915
 Lys Lys Thr Thr Glu Lys Gln Gln Leu Gln Ser Leu Phe Leu Leu Trp
     205                 210                 215

 tca aag ctg act gat aga ctg tgg ttt aag tca act tat tca aaa atg      963
 Ser Lys Leu Thr Asp Arg Leu Trp Phe Lys Ser Thr Tyr Ser Lys Met
 220                 225                 230                 235

 tct tca acc ctg ctg gtc gag aca aga aat ctt tat ggg gta gtt gga     1011
 Ser Ser Thr Leu Leu Val Glu Thr Arg Asn Leu Tyr Gly Val Val Gly
                 240                 245                 250

 gct gaa agc agg tct gca cct gtt cag cat ttg gca gga tgg caa gcg     1059
 Ala Glu Ser Arg Ser Ala Pro Val Gln His Leu Ala Gly Trp Gln Ala
             255                 260                 265

 gag gag cag cag ggt gaa act gac aca gtt ctg tct gca gcg gct ctt     1107
 Glu Glu Gln Gln Gly Glu Thr Asp Thr Val Leu Ser Ala Ala Ala Leu
         270                 275                 280

 tgt gtt gga gtt ggg agt ttc gct gat cca gat gac ctg ccg ggg ctg     1155
 Cys Val Gly Val Gly Ser Phe Ala Asp Pro Asp Asp Leu Pro Gly Leu
     285                 290                 295

 gca cac ttt ttg gag cac atg gta ttc atg ggt agt ttg aaa tat cca     1203
 Ala His Phe Leu Glu His Met Val Phe Met Gly Ser Leu Lys Tyr Pro
 300                 305                 310                 315

 gat gag aat gga ttt gat gcc ttc ctg aag aag cat ggg ggt agt gat     1251
 Asp Glu Asn Gly Phe Asp Ala Phe Leu Lys Lys His Gly Gly Ser Asp
                 320                 325                 330

 aat gcc tca act gat tgt gaa cgc act gtc ttt cag ttt gat gtc cag     1299
 Asn Ala Ser Thr Asp Cys Glu Arg Thr Val Phe Gln Phe Asp Val Gln
             335                 340                 345

 agg aag tac ttc aag gaa gct ctt gat aga tgg gcg cag ttc ttc atc     1347
 Arg Lys Tyr Phe Lys Glu Ala Leu Asp Arg Trp Ala Gln Phe Phe Ile
         350                 355                 360

 cac cca cta atg atc aga gat gca att gac cgt gaa gtt gaa gct gtt     1395
 His Pro Leu Met Ile Arg Asp Ala Ile Asp Arg Glu Val Glu Ala Val
     365                 370                 375

 gat agt gaa tat caa ctt gca agg cct tct gat gca aac aga aag gaa     1443
 Asp Ser Glu Tyr Gln Leu Ala Arg Pro Ser Asp Ala Asn Arg Lys Glu
 380                 385                 390                 395

 atg ttg ttt gga agc ctt gct aga cct gga cat cct atg gga aaa ttt     1491
 Met Leu Phe Gly Ser Leu Ala Arg Pro Gly His Pro Met Gly Lys Phe
                 400                 405                 410

 ttt tgg gga aat gct gag acg ctc aag cat gag cca aga aag aat aat     1539
 Phe Trp Gly Asn Ala Glu Thr Leu Lys His Glu Pro Arg Lys Asn Asn
             415                 420                 425

 att gat aca cat gct aga ttg aga gaa ttc tgg atg cgt tac tac tct     1587
 Ile Asp Thr His Ala Arg Leu Arg Glu Phe Trp Met Arg Tyr Tyr Ser
         430                 435                 440

 tct cat tac atg act tta gtg gtt caa tcc aaa gaa aca ctg gat act     1635
 Ser His Tyr Met Thr Leu Val Val Gln Ser Lys Glu Thr Leu Asp Thr
     445                 450                 455

 ttg gaa aag tgg gtg act gaa atc ttc tct cag ata cca aac aat ggg     1683
 Leu Glu Lys Trp Val Thr Glu Ile Phe Ser Gln Ile Pro Asn Asn Gly
 460                 465                 470                 475

 tta ccc aga cca aac ttt ggc cat tta acg gat cca ttt gac aca cca     1731
 Leu Pro Arg Pro Asn Phe Gly His Leu Thr Asp Pro Phe Asp Thr Pro
                 480                 485                 490

 gca ttt aac aaa ctt tat aga gtt gtt cca atc aga aaa att cat gct     1779
 Ala Phe Asn Lys Leu Tyr Arg Val Val Pro Ile Arg Lys Ile His Ala
             495                 500                 505

 ctg acc atc aca tgg gca ctt cct cct caa cag caa cat tac agg gtg     1827
 Leu Thr Ile Thr Trp Ala Leu Pro Pro Gln Gln Gln His Tyr Arg Val
         510                 515                 520

 aag cca ctt cat tat ata tcc tgg ctg gtt gga cat gaa ggc aaa ggc     1875
 Lys Pro Leu His Tyr Ile Ser Trp Leu Val Gly His Glu Gly Lys Gly
     525                 530                 535

 agc att ctt tct ttc ctt agg aaa aaa tgc tgg gct ctt gca ctg ttt     1923
 Ser Ile Leu Ser Phe Leu Arg Lys Lys Cys Trp Ala Leu Ala Leu Phe
 540                 545                 550                 555

 ggt gga aat ggt gag aca gga ttt gag caa aat tct act tat tca gtg     1971
 Gly Gly Asn Gly Glu Thr Gly Phe Glu Gln Asn Ser Thr Tyr Ser Val
                 560                 565                 570

 ttc agc att tct att aca ttg act gat gag ggt tat gaa cat ttt tat     2019
 Phe Ser Ile Ser Ile Thr Leu Thr Asp Glu Gly Tyr Glu His Phe Tyr
             575                 580                 585

 gag gtt gct tac act gtc ttt cag tat tta aaa atg ctg cag aag cta     2067
 Glu Val Ala Tyr Thr Val Phe Gln Tyr Leu Lys Met Leu Gln Lys Leu
         590                 595                 600

 ggc cca gaa aaa aga att ttt gaa gag att cgg aaa att gag gat aat     2115
 Gly Pro Glu Lys Arg Ile Phe Glu Glu Ile Arg Lys Ile Glu Asp Asn
     605                 610                 615

 gaa ttt cat tac caa gaa cag aca gat cca gtt gag tat gtg gaa aac     2163
 Glu Phe His Tyr Gln Glu Gln Thr Asp Pro Val Glu Tyr Val Glu Asn
 620                 625                 630                 635

 atg tgt gag aac atg cag ctg tac cca ttg cag gac att ctc act gga     2211
 Met Cys Glu Asn Met Gln Leu Tyr Pro Leu Gln Asp Ile Leu Thr Gly
                 640                 645                 650

 gat cag ctt ctt ttt gaa tac aag cca gaa gtc att ggt gaa gcc ttg     2259
 Asp Gln Leu Leu Phe Glu Tyr Lys Pro Glu Val Ile Gly Glu Ala Leu
             655                 660                 665

 aat cag cta gtt cct caa aaa gca aat ctt gtt tta ctg tct ggt gct     2307
 Asn Gln Leu Val Pro Gln Lys Ala Asn Leu Val Leu Leu Ser Gly Ala
         670                 675                 680

 aat gag gga aaa tgt gac ctc aag gag aaa tgg ttt gga act caa tat     2355
 Asn Glu Gly Lys Cys Asp Leu Lys Glu Lys Trp Phe Gly Thr Gln Tyr
     685                 690                 695

 agt ata gaa gat att gaa aac tct tgg gct gaa ctg tgg aat agt aat     2403
 Ser Ile Glu Asp Ile Glu Asn Ser Trp Ala Glu Leu Trp Asn Ser Asn
 700                 705                 710                 715

 ttc gaa tta aat cca gat ctt cat ctt cca gct gaa aac aag tac ata     2451
 Phe Glu Leu Asn Pro Asp Leu His Leu Pro Ala Glu Asn Lys Tyr Ile
                 720                 725                 730

 gcc acg gac ttt acg ttg aag gct ttc gat tgc ccg gaa aca gaa tac     2499
 Ala Thr Asp Phe Thr Leu Lys Ala Phe Asp Cys Pro Glu Thr Glu Tyr
             735                 740                 745

 cca gtt aaa att gtg aat act cca caa ggt tgc ctg tgg tat aag aaa     2547
 Pro Val Lys Ile Val Asn Thr Pro Gln Gly Cys Leu Trp Tyr Lys Lys
         750                 755                 760

 gac aac aaa ttc aaa atc ccc aaa gca tat ata cgt ttc cat cta att     2595
 Asp Asn Lys Phe Lys Ile Pro Lys Ala Tyr Ile Arg Phe His Leu Ile
     765                 770                 775

 tca ccg ttg ata cag aaa tct gca gca aat gtg gtc ctc ttt gat atc     2643
 Ser Pro Leu Ile Gln Lys Ser Ala Ala Asn Val Val Leu Phe Asp Ile
 780                 785                 790                 795

 ttt gtc aat atc ctt acg cat aac ctt gcg gaa cca gct tat gaa gca     2691
 Phe Val Asn Ile Leu Thr His Asn Leu Ala Glu Pro Ala Tyr Glu Ala
                 800                 805                 810

 gat gtg gca cag ctg gag tat aaa ctg gta gct gga gaa cat ggt tta     2739
 Asp Val Ala Gln Leu Glu Tyr Lys Leu Val Ala Gly Glu His Gly Leu
             815                 820                 825

 att att cga gtg aaa gga ttt aac cac aaa cta cct cta ctg ttt cag     2787
 Ile Ile Arg Val Lys Gly Phe Asn His Lys Leu Pro Leu Leu Phe Gln
         830                 835                 840

 ctc att att gac tac tta gct gag ttc aat tcc aca cca gct gtc ttt     2835
 Leu Ile Ile Asp Tyr Leu Ala Glu Phe Asn Ser Thr Pro Ala Val Phe
     845                 850                 855

 aca atg ata act gag cag ttg aag aag acc tac ttt aac atc ctc atc     2883
 Thr Met Ile Thr Glu Gln Leu Lys Lys Thr Tyr Phe Asn Ile Leu Ile
 860                 865                 870                 875

 aag ccc gag act ttg gcc aaa gat gta cgg ctt tta atc ttg gaa tat     2931
 Lys Pro Glu Thr Leu Ala Lys Asp Val Arg Leu Leu Ile Leu Glu Tyr
                 880                 885                 890

 gcc cgt tgg tct atg att gac aag tac cag gct ttg atg gac ggc ctt     2979
 Ala Arg Trp Ser Met Ile Asp Lys Tyr Gln Ala Leu Met Asp Gly Leu
             895                 900                 905

 tcc ctt gag tct ctg ctg agc ttc gtc aaa gaa ttc aaa tcc cag ctc     3027
 Ser Leu Glu Ser Leu Leu Ser Phe Val Lys Glu Phe Lys Ser Gln Leu
         910                 915                 920

 ttt gtg gag ggc ctg gta caa ggg aat gtc aca agc aca gaa tct atg     3075
 Phe Val Glu Gly Leu Val Gln Gly Asn Val Thr Ser Thr Glu Ser Met
     925                 930                 935

 gat ttc ctg aaa tat gtt gtt gac aaa cta aac ttc aag cct ctg gag     3123
 Asp Phe Leu Lys Tyr Val Val Asp Lys Leu Asn Phe Lys Pro Leu Glu
 940                 945                 950                 955

 cag gag atg cct gtg cag ttc cag gtg gta gag ctg ccc agt ggc cac     3171
 Gln Glu Met Pro Val Gln Phe Gln Val Val Glu Leu Pro Ser Gly His
                 960                 965                 970

 cat cta tgc aaa gtg aaa gct ctg aac aag ggt gat gcc aac tct gaa     3219
 His Leu Cys Lys Val Lys Ala Leu Asn Lys Gly Asp Ala Asn Ser Glu
             975                 980                 985

 gtc act gtg tac tac cag tca ggt acc agg agt cta aga gaa tat acg     3267
 Val Thr Val Tyr Tyr Gln Ser Gly Thr Arg Ser Leu Arg Glu Tyr Thr
         990                 995                1000

 ctt atg gag ctg ctt gtg atg cac atg gaa gaa cct tgt ttt gac ttc     3315
 Leu Met Glu Leu Leu Val Met His Met Glu Glu Pro Cys Phe Asp Phe
    1005                1010                1015

 ctt cga acc aag cag acc ctt ggg tac cat gtc tac cct acc tgt agg     3363
 Leu Arg Thr Lys Gln Thr Leu Gly Tyr His Val Tyr Pro Thr Cys Arg
1020                1025                1030                1035

 aac aca tcc ggg att cta gga ttt tct gtc act gtg ggg act cag gca     3411
 Asn Thr Ser Gly Ile Leu Gly Phe Ser Val Thr Val Gly Thr Gln Ala
                1040                1045                1050

 acc aaa tac aat tct gaa gtt gtt gat aag aag ata gaa gag ttt ctt     3459
 Thr Lys Tyr Asn Ser Glu Val Val Asp Lys Lys Ile Glu Glu Phe Leu
            1055                1060                1065

 tct agc ttt gag gag aag att gag aac ctc act gaa gag gca ttc aac     3507
 Ser Ser Phe Glu Glu Lys Ile Glu Asn Leu Thr Glu Glu Ala Phe Asn
        1070                1075                1080

 acc cag gtc aca gct ctc atc aag ctg aag gag tgt gag gat acc cac     3555
 Thr Gln Val Thr Ala Leu Ile Lys Leu Lys Glu Cys Glu Asp Thr His
    1085                1090                1095

 ctt ggg gag gag gtg gat agg aac tgg aat gaa gtg gtt aca cag cag     3603
 Leu Gly Glu Glu Val Asp Arg Asn Trp Asn Glu Val Val Thr Gln Gln
1100                1105                1110                1115

 tac ctc ttt gac cgc ctt gcc cac gag att gaa gca ctg aag tca ttc     3651
 Tyr Leu Phe Asp Arg Leu Ala His Glu Ile Glu Ala Leu Lys Ser Phe
                1120                1125                1130

 tca aaa tca gac ctg gtc aac tgg ttc aag gcc cat aga ggg cca gga     3699
 Ser Lys Ser Asp Leu Val Asn Trp Phe Lys Ala His Arg Gly Pro Gly
            1135                1140                1145

 agt aaa atg ctc agc gtt cat gtt gtt gga tat ggg aag tat gaa ctg     3747
 Ser Lys Met Leu Ser Val His Val Val Gly Tyr Gly Lys Tyr Glu Leu
        1150                1155                1160

 gaa gag gat ggt acc cct tct agt gag gat tca aat tct tct tgt gaa     3795
 Glu Glu Asp Gly Thr Pro Ser Ser Glu Asp Ser Asn Ser Ser Cys Glu
    1165                1170                1175

 gtg atg cag ctg acc tac ctg cca acc tct cct ctg ctg gca gat tgt     3843
 Val Met Gln Leu Thr Tyr Leu Pro Thr Ser Pro Leu Leu Ala Asp Cys
1180                1185                1190                1195

 atc atc ccc att act gat atc agg gct ttc aca aca aca ctc aac ctt     3891
 Ile Ile Pro Ile Thr Asp Ile Arg Ala Phe Thr Thr Thr Leu Asn Leu
                1200                1205                1210

 ctc ccc tac cat aaa ata gtc aaa taaataaact gcagtcacgt tggcctgaag    3945
 Leu Pro Tyr His Lys Ile Val Lys 
            1215

 caatgtgtat tttaaaaaaa aaaaa                                         3970




      <210> 102
      <211> 1199
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (96)..(611)

      <400> 102
 tggagtccag acccgacggc cggcccagtt ccacgcaccc agcgagccca agcgccttct     60

 ccgcaccagg gaagccccac ccaccagaag ccaag   atg tcc agc aag cgg gcc     113
                                          Met Ser Ser Lys Arg Ala
                                            1               5

 aaa gcc aag acc acc aag aag cgg cca cag cgg gcc aca tcc aat gtc      161
 Lys Ala Lys Thr Thr Lys Lys Arg Pro Gln Arg Ala Thr Ser Asn Val
              10                  15                  20

 ttc gca atg ttt gac cag tcc cag atc cag gag ttt aag gag gct ttc      209
 Phe Ala Met Phe Asp Gln Ser Gln Ile Gln Glu Phe Lys Glu Ala Phe
          25                  30                  35

 aac atg att gac cag aac cgt gat ggc ttc att gac aag gag gac ctg      257
 Asn Met Ile Asp Gln Asn Arg Asp Gly Phe Ile Asp Lys Glu Asp Leu
      40                  45                  50

 cac gac atg ctg gcc tcg ctg ggg aag aac ccc aca gac gaa tac ctg      305
 His Asp Met Leu Ala Ser Leu Gly Lys Asn Pro Thr Asp Glu Tyr Leu
  55                  60                  65                  70

 gag ggc atg atg agc gag gcc ccg ggg ccc atc aac ttc acc atg ttc      353
 Glu Gly Met Met Ser Glu Ala Pro Gly Pro Ile Asn Phe Thr Met Phe
                  75                  80                  85

 ctc acc atg ttt ggg gag aag ctg aac ggc acg gac ccc gag gat gtg      401
 Leu Thr Met Phe Gly Glu Lys Leu Asn Gly Thr Asp Pro Glu Asp Val
              90                  95                 100

 att cgc aac gcc ttt gcc tgc ttc gac gag gaa gcc tca ggt ttc atc      449
 Ile Arg Asn Ala Phe Ala Cys Phe Asp Glu Glu Ala Ser Gly Phe Ile
         105                 110                 115

 cat gag gac cac ctc cgg gag ctg ctc acc acc atg ggt gac cgc ttc      497
 His Glu Asp His Leu Arg Glu Leu Leu Thr Thr Met Gly Asp Arg Phe
     120                 125                 130

 aca gat gag gaa gtg gac gag atg tac cgg gag gca ccc att gat aag      545
 Thr Asp Glu Glu Val Asp Glu Met Tyr Arg Glu Ala Pro Ile Asp Lys
 135                 140                 145                 150

 aaa ggc aac ttc aac tac gtg gag ttc acc cgc atc ctc aaa cat ggc      593
 Lys Gly Asn Phe Asn Tyr Val Glu Phe Thr Arg Ile Leu Lys His Gly
                 155                 160                 165

 gcc aag gat aaa gac gac taggcc accccagccc cctgacaccc cagcccccgc      647
 Ala Lys Asp Lys Asp Asp 
             170

 cagtcacccc tccccgcaca cacccgtcca taccagctcc ctgcccatga ccctcgctca    707

 gggatccccc tttgaggggt tagggtccca gttcccagtg gaagaaacag gccaggagaa    767

 gtgcgtgccg agctgaggca gatgttccca cagtgacccc agagccctgg gctatagtct    827

 ctgacccctc caaggaaaga ccaccttctg gggacatggg ctggagggca ggacctagag    887

 gcaccaaggg aaggccccat tccggggctg ttccccgagg aggaagggaa ggggctctgt    947

 gtgcccccca ggaggaagag gccctgagtc ctgggatcag acaccccttc acgtgtatcc   1007

 ccacacaaat gcaagctcac caaggtcccc tctcagtccc cttccctaca ccctgaccgg   1067

 ccactgccgc acacccaccc agagcacgcc acccgccatg ggagtgtgct caggagtcgc   1127

 gggcagcgtg gacatctgtc ccagaggggg cagaatctcc aatagaggac tgagcactga   1187

 aaaaaaaaaa aa                                                       1199




      <210> 103
      <211> 1484
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (994)..(1365)

      <400> 103
 ctgccccacc accgctgctc ctcagcaggc gcctcaccag cctccacacc ccttgcgccc     60

 gcagaaacgc gcctggccct gagctgtcac caccgacact ctccaggctc cggacacgat    120

 gcaggccatc aagtgtgtgg tggtgggaga tggggccgtg ggcaagacct gccttctcat    180

 cagctacacc accaacgcct ttcccggaga gtacatcccc accgtgtttg acaactattc    240

 agccaatgtg atggtggaca gcaagccagt gaacctgggg ctgtgggaca ctgctgggca    300

 ggaggactac gaccgtctcc ggccgctctc ctatccacag acggacgtct tcctcatctg    360

 cttctccctc gtcagcccag cctcttatga gaacgtccgc gccaagtggt tcccagaagt    420

 gcggcaccac tgccccagca cacccatcat cctggtgggc accaagctgg acctgcggga    480

 cgacaaggac accatcgaga aactgaagga gaagaagctg gctcccatca cctacccgca    540

 gggcctggca ctggccaagg agattgactc ggtgaaatac ctggagtgct cagctctcac    600

 ccagagaggc ctgaaaaccg tgttcgacga ggccatccgg gccgtgctgt gccctcagcc    660

 cacgcggcag cagaagcgcg cctgcagcct cctctagggg ttgcacccca gcgctcccac    720

 ctagatgggt ctgatcctcc aggatcccca cccaaagcct gatggcaccc cggctggcca    780

 tgctgtcccc tccctgtggc gtttcttagc agatggctgc agagcttcgt tgatggtctt    840

 ttctgtactg gaggcctcct gaggccagga acgtgcaaat ttgcaggtgc tgcatcccaa    900

 gcccctcatg ctcctgcctt cctgagggcc agaggggagc cccaggaccc attaagccac    960

 ccccgtgttc ctgccgtcag tgccaactgc cgc atg tgg aag cat cta ccc gtt    1014
                                      Met Trp Lys His Leu Pro Val
                                        1               5

 cac tcc agt ccc acc cca cgc ctg act ccc ctc tgg aaa ctg cag gcc     1062
 His Ser Ser Pro Thr Pro Arg Leu Thr Pro Leu Trp Lys Leu Gln Ala
          10                  15                  20

 aga tgg ttg ctg cca caa ctt gtg tac ctt cag gga tgg ggc tct tac     1110
 Arg Trp Leu Leu Pro Gln Leu Val Tyr Leu Gln Gly Trp Gly Ser Tyr
      25                  30                  35

 tcc ctc ctg agg cca gct gct cta ata tcg atg gtc ctg ctt gcc aga     1158
 Ser Leu Leu Arg Pro Ala Ala Leu Ile Ser Met Val Leu Leu Ala Arg
  40                  45                  50                  55

 gag ttc ctc tac cca gca aaa atg agt gtc tca gaa gtg tgc tcc tct     1206
 Glu Phe Leu Tyr Pro Ala Lys Met Ser Val Ser Glu Val Cys Ser Ser
                  60                  65                  70

 ggc ctc agt tct cct ctt ttg gaa caa cat aaa aca aat tta att ttc     1254
 Gly Leu Ser Ser Pro Leu Leu Glu Gln His Lys Thr Asn Leu Ile Phe
              75                  80                  85

 tac gcc tct ggg gat atc tgc tca gcc aat gga aaa tct ggg ttc aac     1302
 Tyr Ala Ser Gly Asp Ile Cys Ser Ala Asn Gly Lys Ser Gly Phe Asn
          90                  95                 100

 cag ccc ctg cca ttt ctt aag act ttc tgc tcc act cac agg atc ctg     1350
 Gln Pro Leu Pro Phe Leu Lys Thr Phe Cys Ser Thr His Arg Ile Leu
     105                 110                 115

 agc tgc act tac ctg tgagagtctt caaactttta aaccttgcca gtcaggactt     1405
 Ser Cys Thr Tyr Leu 
 120

 ttgctattgc aaatagaaaa cccaactcaa cctgcttaag cagaaaataa atttattgat   1465

 tcaaaaaaaa aaaaaaagg                                                1484




      <210> 104
      <211> 1072
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(642)

      <400> 104
  atg gtg tcc aag tca ctt tgg agg aaa tgg gag cag aag ctg gat tgt      48
  Met Val Ser Lys Ser Leu Trp Arg Lys Trp Glu Gln Lys Leu Asp Cys
    1               5                  10                  15

 gaa ttg aag aaa caa ata cac aat tat cca gag tgc aga att ctt cag       96
 Glu Leu Lys Lys Gln Ile His Asn Tyr Pro Glu Cys Arg Ile Leu Gln
              20                  25                  30

 gat gaa atc tgt agg aca atg agc tgg ttg gag cag ctc atc agt gac      144
 Asp Glu Ile Cys Arg Thr Met Ser Trp Leu Glu Gln Leu Ile Ser Asp
          35                  40                  45

 tgt cac act ctg act acg gag ctg gcc agc ccc acg ctt ctt acc atg      192
 Cys His Thr Leu Thr Thr Glu Leu Ala Ser Pro Thr Leu Leu Thr Met
      50                  55                  60

 gaa atg gac ctt cgt cgc ctg cca caa cct gct ctt gct tgt gaa agg      240
 Glu Met Asp Leu Arg Arg Leu Pro Gln Pro Ala Leu Ala Cys Glu Arg
  65                  70                  75                  80

 cag agg gct gcc tat aaa gag gag agc tgg ttt cag act tca gaa gga      288
 Gln Arg Ala Ala Tyr Lys Glu Glu Ser Trp Phe Gln Thr Ser Glu Gly
                  85                  90                  95

 cac ggg cag cag aca gtg gtc agt cct ttc ttg gct ctg ctg aca ctc      336
 His Gly Gln Gln Thr Val Val Ser Pro Phe Leu Ala Leu Leu Thr Leu
             100                 105                 110

 gag ccc aca ttc cgt cac ctg ctc aga atc atg cag gtc tcc act gct      384
 Glu Pro Thr Phe Arg His Leu Leu Arg Ile Met Gln Val Ser Thr Ala
         115                 120                 125

 gcc ctt gct gtc ctc ctc tgc acc atg gct ctc tgc aac cag ttc tct      432
 Ala Leu Ala Val Leu Leu Cys Thr Met Ala Leu Cys Asn Gln Phe Ser
     130                 135                 140

 gca tca ctt gct gct gac acg ccg acc gcc tgc tgc ttc agc tac acc      480
 Ala Ser Leu Ala Ala Asp Thr Pro Thr Ala Cys Cys Phe Ser Tyr Thr
 145                 150                 155                 160

 tcc cgg cag att cca cag aat ttc ata gct gac tac ttt gag acg agc      528
 Ser Arg Gln Ile Pro Gln Asn Phe Ile Ala Asp Tyr Phe Glu Thr Ser
                 165                 170                 175

 agc cag tgc tcc aag ccc ggt gtc atc ttc cta acc aag cga agc cgg      576
 Ser Gln Cys Ser Lys Pro Gly Val Ile Phe Leu Thr Lys Arg Ser Arg
             180                 185                 190

 cag gtc tgt gct gac ccc agt gag gag tgg gtc cag aaa tat gtc agc      624
 Gln Val Cys Ala Asp Pro Ser Glu Glu Trp Val Gln Lys Tyr Val Ser
         195                 200                 205

 gac ctg gag ctg agt gcc tgaggg gtccagaagc ttcgaggccc agcgacctcg      678
 Asp Leu Glu Leu Ser Ala 
     210

 gtgggcccag tggggaggag caggagcctg agccttggga acatgcgtgt gacctccaca    738

 gctacctctt ctatggactg gttgttgcca aacagccaca ctgtgggact cttcttaact    798

 taaattttaa tttatttata ctatttagtt tttgtaattt attttcgatt tcacagtgtg    858

 tttgtgattg tttgctctga gagttcccct gtcccctccc ccttccctca caccgcgtct    918

 ggtgacaacc gagtggctgt catcagcctg tgtaggcagt catggcacca aagccaccag    978

 actgacaaat gtgtatcgga tgcttttgtt cagggctgtg atcggcctgg ggaaataata   1038

 aagatgctct tttaaaaggt aaaaaaaaaa aaaa                               1072




      <210> 105
      <211> 620
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (197)..(472)

      <400> 105
 gaaaggtgat accatctgac agtcattttc tcacgttggt cttctaaagt cacctatttc     60

 ttgtgtgtgc acatcacacc atttcctgtt tctttataac ccgacaaggg taggagtgcc    120

 tgtttcccct gctgggcaca ccagacaatc gtaatcacaa aacagacact gagccaggga    180

 cccaaagggt gtgatc    atg aga gtt acc ggg aca gca gta ggc atg aca     229
                      Met Arg Val Thr Gly Thr Ala Val Gly Met Thr
                        1               5                  10

 gtc acc agg aag gac aag ggt gct ctg ttg tta gtg gcc aca cac caa      277
 Val Thr Arg Lys Asp Lys Gly Ala Leu Leu Leu Val Ala Thr His Gln
              15                  20                  25

 ttt gac aag gag tgt tgc gaa att ttt att tat tta ttt att tat ttt      325
 Phe Asp Lys Glu Cys Cys Glu Ile Phe Ile Tyr Leu Phe Ile Tyr Phe
          30                  35                  40

 gag atg gag ttt cac tct tgt tgc cca ggc tgg agt gcg gtg gta caa      373
 Glu Met Glu Phe His Ser Cys Cys Pro Gly Trp Ser Ala Val Val Gln
      45                  50                  55

 tct cgg ctc act gca acc tcc acc tcc cag gtt caa gcg att ctc ctg      421
 Ser Arg Leu Thr Ala Thr Ser Thr Ser Gln Val Gln Ala Ile Leu Leu
  60                  65                  70                  75

 cct cag cct ccc aag tac ctg gga cta cag gtg cgt gcc acc aca ccc      469
 Pro Gln Pro Pro Lys Tyr Leu Gly Leu Gln Val Arg Ala Thr Thr Pro
                  80                  85                  90

 agc taaa ttttgtgttt ttagtagaga tggggtttca ccatgttggc caggatggtc      526
 Ser 


 ttgaacccct gacctcatga tctgcctgcc tcggcctccc aaagtgctgg gattacaggc    586

 atgagccacc acgcccagcc aaaatatttt ttta                                620




      <210> 106
      <211> 2191
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (422)..(1954)

      <400> 106
 cccacgcgtc cgcagagagc aagagagagg aactggggtt tgcgaacctt gtggctttgt     60

 ctgtttcctg tttcagcaag gctgctgtgc aaaaagaaag acggtaccaa gaagggacgt    120

 gttaatgggg cccagaccta tggattgaaa gcgtgtgctt tacccatctg ctgtcttgct    180

 ccatcttgag accatagcca agatctgtcc aggactggaa tgctttcccg agtggcttga    240

 gttggagcct gggactacga gcagccttat tgaggtacaa ttcatgtgct tgtgggtttg    300

 gatggcacaa tctgtgtctg ggctaaggaa agcagacttg gcaccaacat tatacctgac    360

 agatccatgc atctattgca ggaacttgta agccaagcgc aacaggtgct tggaggtcat    420

 c    atg atc agc cca gac ccc agg ccc tcc cct ggc ttg gcc cgg ggg     466
      Met Ile Ser Pro Asp Pro Arg Pro Ser Pro Gly Leu Ala Arg Gly
        1               5                  10                  15

 gct gag agc tat gag gcc aag tgt gag cgc agg caa gag atc cgg gaa      514
 Ala Glu Ser Tyr Glu Ala Lys Cys Glu Arg Arg Gln Glu Ile Arg Glu
                  20                  25                  30

 agc cgc cgc tgc cgt ccc aat gtg acc act tgc cgc cag gtg ggg aag      562
 Ser Arg Arg Cys Arg Pro Asn Val Thr Thr Cys Arg Gln Val Gly Lys
              35                  40                  45

 acg ctg agg atc cag cag aga gag cag ctc cag aga gct cga ctg cag      610
 Thr Leu Arg Ile Gln Gln Arg Glu Gln Leu Gln Arg Ala Arg Leu Gln
          50                  55                  60

 cag ttc ttc agg agg agg aac ctg gag cta gag gag aag ggc aaa gcg      658
 Gln Phe Phe Arg Arg Arg Asn Leu Glu Leu Glu Glu Lys Gly Lys Ala
      65                  70                  75

 cag cat ccc cag gcc agg gag caa ggg ccc tcc agg cgg cca gga cag      706
 Gln His Pro Gln Ala Arg Glu Gln Gly Pro Ser Arg Arg Pro Gly Gln
  80                  85                  90                  95

 gtg aca ggc acc agc tct gaa gtc ttt cca gcc cag cat cct cct ccc      754
 Val Thr Gly Thr Ser Ser Glu Val Phe Pro Ala Gln His Pro Pro Pro
                 100                 105                 110

 tca ggc atc tgc agg gat ctg tct gac cac ctc tcc tca cag gct ggg      802
 Ser Gly Ile Cys Arg Asp Leu Ser Asp His Leu Ser Ser Gln Ala Gly
             115                 120                 125

 ggc ctt cct cca cag gac act ccc atc aag aag cca ccc aaa cac cac      850
 Gly Leu Pro Pro Gln Asp Thr Pro Ile Lys Lys Pro Pro Lys His His
         130                 135                 140

 cgt ggt act cag aca aag gca gaa gga cca aca att aag aac gat gcc      898
 Arg Gly Thr Gln Thr Lys Ala Glu Gly Pro Thr Ile Lys Asn Asp Ala
     145                 150                 155

 agt cag caa acc aat tac gga gtt gca gtt ctg gat aag gaa atc atc      946
 Ser Gln Gln Thr Asn Tyr Gly Val Ala Val Leu Asp Lys Glu Ile Ile
 160                 165                 170                 175

 cag ctt tct gat tac ctc aaa gag gcc cta caa agg gag ctg gtc cta      994
 Gln Leu Ser Asp Tyr Leu Lys Glu Ala Leu Gln Arg Glu Leu Val Leu
                 180                 185                 190

 aaa cag aaa atg gtg att ctc caa gac cta ctg tcc act ctg att cag     1042
 Lys Gln Lys Met Val Ile Leu Gln Asp Leu Leu Ser Thr Leu Ile Gln
             195                 200                 205

 gcc tct gac agc tct tgg aag gga cag ctt aat gaa gac aaa ctg aag     1090
 Ala Ser Asp Ser Ser Trp Lys Gly Gln Leu Asn Glu Asp Lys Leu Lys
         210                 215                 220

 ggg aaa ctg aga tcc tta gaa aac cag cta tac acc tgt acc cag aaa     1138
 Gly Lys Leu Arg Ser Leu Glu Asn Gln Leu Tyr Thr Cys Thr Gln Lys
     225                 230                 235

 tac tcc cct tgg gga atg aaa aaa gta cta ctg gag atg gaa gac cag     1186
 Tyr Ser Pro Trp Gly Met Lys Lys Val Leu Leu Glu Met Glu Asp Gln
 240                 245                 250                 255

 aaa aac agc tat gag cag aag gcc aag gag tca ctg cag aaa gtg ctg     1234
 Lys Asn Ser Tyr Glu Gln Lys Ala Lys Glu Ser Leu Gln Lys Val Leu
                 260                 265                 270

 gag gag aaa atg aat gca gag cag caa cta cag agc aca cag cga tcc     1282
 Glu Glu Lys Met Asn Ala Glu Gln Gln Leu Gln Ser Thr Gln Arg Ser
             275                 280                 285

 ctg gcc ctg gca gag cag aag tgt gaa gag tgg agg agc cag tat gag     1330
 Leu Ala Leu Ala Glu Gln Lys Cys Glu Glu Trp Arg Ser Gln Tyr Glu
         290                 295                 300

 gct ctg aag gag gac tgg agg acc ctt ggg acc cag cac agg gag ctg     1378
 Ala Leu Lys Glu Asp Trp Arg Thr Leu Gly Thr Gln His Arg Glu Leu
     305                 310                 315

 gag agc caa ctc cac gtg ctt cag tcc aaa ctg cag gga gca gat agc     1426
 Glu Ser Gln Leu His Val Leu Gln Ser Lys Leu Gln Gly Ala Asp Ser
 320                 325                 330                 335

 agg gac tta cag atg aac cag gcc ctg cga ttt ttg gaa aat gag cac     1474
 Arg Asp Leu Gln Met Asn Gln Ala Leu Arg Phe Leu Glu Asn Glu His
                 340                 345                 350

 cag caa ctg cag gcc aag att gaa tgc ctg caa ggg gac aga gac ctg     1522
 Gln Gln Leu Gln Ala Lys Ile Glu Cys Leu Gln Gly Asp Arg Asp Leu
             355                 360                 365

 tgc agc ttg gat acc cag gac cta caa gat caa cta aaa agg tca gag     1570
 Cys Ser Leu Asp Thr Gln Asp Leu Gln Asp Gln Leu Lys Arg Ser Glu
         370                 375                 380

 gca gag aaa ctc acc ctg gtg acc aga gta cag cag ttg cag ggt ttg     1618
 Ala Glu Lys Leu Thr Leu Val Thr Arg Val Gln Gln Leu Gln Gly Leu
     385                 390                 395

 ctt caa aat caa tcc tta cag ctt caa gaa cag gag aaa ctc tta aca     1666
 Leu Gln Asn Gln Ser Leu Gln Leu Gln Glu Gln Glu Lys Leu Leu Thr
 400                 405                 410                 415

 aag aaa gat cag gct ttg ccc gtg tgg agt cca aag tcc ttc cct aac     1714
 Lys Lys Asp Gln Ala Leu Pro Val Trp Ser Pro Lys Ser Phe Pro Asn
                 420                 425                 430

 gaa gtg gag cct gag ggt aca ggg aag gag aaa gac tgg gat ctc aga     1762
 Glu Val Glu Pro Glu Gly Thr Gly Lys Glu Lys Asp Trp Asp Leu Arg
             435                 440                 445

 gac cag ctg caa aag aag act ttg cag ctc cag gcc aag gaa aag gag     1810
 Asp Gln Leu Gln Lys Lys Thr Leu Gln Leu Gln Ala Lys Glu Lys Glu
         450                 455                 460

 tgc aga gaa ctg cat tca gaa tta gac aac ctc agt gac gag tat ctc     1858
 Cys Arg Glu Leu His Ser Glu Leu Asp Asn Leu Ser Asp Glu Tyr Leu
     465                 470                 475

 tcc tgc ctg cgt aag ctg cag cac tgt cga gaa gag ctg aac cag agc     1906
 Ser Cys Leu Arg Lys Leu Gln His Cys Arg Glu Glu Leu Asn Gln Ser
 480                 485                 490                 495

 cag cag ctg cct ccc aga agg cca atg tgg gca aag gcc tcc cag tgc     1954
 Gln Gln Leu Pro Pro Arg Arg Pro Met Trp Ala Lys Ala Ser Gln Cys 
                 500                 505                 510

 taatggtggt gattgctcca gcactggcag tgttcctggc caataaaaac aacctgatga   2014

 tttgaataat ttgtgacaac tgccttgggt gaaaatcaaa agcaagcaac tcagcgaaaa   2074

 actcaaaagg tttgggtaca ttacagcttg ggttttccaa ctgacttagg atttctgact   2134

 ttttattaat ttcttaacct actgtaaata aacttcacct gaccagattg ttgcaat      2191




      <210> 107
      <211> 1405
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (284)..(1366)

      <400> 107
 gtatttttca aataaaatga ttaattctac taccaaataa atcttaattt ctagtctact     60

 tctagtttgc aagaggagct ttaaatgtat ttgtttactt aacatttaaa aatccatttc    120

 tccttaaaat gaaacacttt ttttaaggta ggtaatattt taatttgact agaagttagt    180

 ttttctttct tagtttaagc tactttgtta gtcttacaat tttaataagt atagttatta    240

 cctagtgaca tttctgtttg tttttttaag gttaacattc aag  atg gta cat gct     295
                                                  Met Val His Ala
                                                    1

 gaa gcc ttt tct cgt cct ttg agt cgg aat gaa gtt gtt ggt tta att      343
 Glu Ala Phe Ser Arg Pro Leu Ser Arg Asn Glu Val Val Gly Leu Ile
   5                  10                  15                  20

 ttc cgt ttg aca ata ttt ggt gca gtg aca tac ttt act atc aaa tgg      391
 Phe Arg Leu Thr Ile Phe Gly Ala Val Thr Tyr Phe Thr Ile Lys Trp
                  25                  30                  35

 atg gta gat gca att gat cca acc aga aag caa aaa gta gaa gct cag      439
 Met Val Asp Ala Ile Asp Pro Thr Arg Lys Gln Lys Val Glu Ala Gln
              40                  45                  50

 aaa cag gca gaa aaa cta atg aag caa att gga gtg aaa aat gtg aag      487
 Lys Gln Ala Glu Lys Leu Met Lys Gln Ile Gly Val Lys Asn Val Lys
          55                  60                  65

 ctc tca gaa tat gaa atg agt att gct gct cat ctt gta gac cct ctt      535
 Leu Ser Glu Tyr Glu Met Ser Ile Ala Ala His Leu Val Asp Pro Leu
      70                  75                  80

 aat atg cat gtt act tgg agt gat ata gca ggt tta gat gat gtc att      583
 Asn Met His Val Thr Trp Ser Asp Ile Ala Gly Leu Asp Asp Val Ile
  85                  90                  95                 100

 acg gat ctg aaa gac aca gtc atc tta cct atc aaa aag aaa cat ttg      631
 Thr Asp Leu Lys Asp Thr Val Ile Leu Pro Ile Lys Lys Lys His Leu
                 105                 110                 115

 ttt gag aat tcc agg ctt ctg cag cct cca aaa ggt gtt ctt ctc tat      679
 Phe Glu Asn Ser Arg Leu Leu Gln Pro Pro Lys Gly Val Leu Leu Tyr
             120                 125                 130

 ggg cct cca ggc tgt ggt aaa acg ttg att gcc aag gcc aca gcc aaa      727
 Gly Pro Pro Gly Cys Gly Lys Thr Leu Ile Ala Lys Ala Thr Ala Lys
         135                 140                 145

 gaa gca ggc tgt cga ttt att aac ctt cag cct tcg aca ctg acc gat      775
 Glu Ala Gly Cys Arg Phe Ile Asn Leu Gln Pro Ser Thr Leu Thr Asp
     150                 155                 160

 aag tgg tat gga gaa tct cag aaa ttg gct gct gct gtc ttc tcc ctt      823
 Lys Trp Tyr Gly Glu Ser Gln Lys Leu Ala Ala Ala Val Phe Ser Leu
 165                 170                 175                 180

 gcc ata aag cta caa cca tcc atc atc ttt ata gat gaa ata gac tcc      871
 Ala Ile Lys Leu Gln Pro Ser Ile Ile Phe Ile Asp Glu Ile Asp Ser
                 185                 190                 195

 ttt cta cga aac cgt tca agt tct gac cat gaa gct aca gcc atg atg      919
 Phe Leu Arg Asn Arg Ser Ser Ser Asp His Glu Ala Thr Ala Met Met
             200                 205                 210

 aaa gct cag ttt atg agt ctc tgg gat gga ttg gat act gat cac agc      967
 Lys Ala Gln Phe Met Ser Leu Trp Asp Gly Leu Asp Thr Asp His Ser
         215                 220                 225

 tgc cag gtc ata gta atg gga gct acc aat cgt cct cag gac ctt gac     1015
 Cys Gln Val Ile Val Met Gly Ala Thr Asn Arg Pro Gln Asp Leu Asp
     230                 235                 240

 tcg gct ata atg aga aga atg cct aca aga ttt cat atc aac cag cct     1063
 Ser Ala Ile Met Arg Arg Met Pro Thr Arg Phe His Ile Asn Gln Pro
 245                 250                 255                 260

 gct tta aaa cag aga gaa gca atc ctg aaa ctc atc ttg aaa aat gaa     1111
 Ala Leu Lys Gln Arg Glu Ala Ile Leu Lys Leu Ile Leu Lys Asn Glu
                 265                 270                 275

 aat gtg gat agg cat gta gac ctg cta gaa gtt gcc cag gaa act gat     1159
 Asn Val Asp Arg His Val Asp Leu Leu Glu Val Ala Gln Glu Thr Asp
             280                 285                 290

 ggg ttt tca gga agt gac cta aaa gag atg tgt cga gat gct gcc ctc     1207
 Gly Phe Ser Gly Ser Asp Leu Lys Glu Met Cys Arg Asp Ala Ala Leu
         295                 300                 305

 ctc tgt gtt aga gaa tat gtt aat tct aca tca gaa gaa agc cat gac     1255
 Leu Cys Val Arg Glu Tyr Val Asn Ser Thr Ser Glu Glu Ser His Asp
     310                 315                 320

 gaa gat gaa att cgg cct gtt caa cag cag gac ctg cat cgg gca att     1303
 Glu Asp Glu Ile Arg Pro Val Gln Gln Gln Asp Leu His Arg Ala Ile
 325                 330                 335                 340

 gaa aag atg aag aaa tca aag gat gca gca ttt cag aat gtt tta aca     1351
 Glu Lys Met Lys Lys Ser Lys Asp Ala Ala Phe Gln Asn Val Leu Thr
                 345                 350                 355

 cat gtt tgt tta gat taagagtaaa gatcatttgt acagttcaaa aaaaaaaaa      1405
 His Val Cys Leu Asp 
             360





      <210> 108
      <211> 1206
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (95)..(976)

      <400> 108
 gcacgagcac aggtgacgct cctcccgcct gcctagcaga gctccaggcg cacatccgca     60

 gtcagccacc tcgcgcgcgc ctccaggagc aagg    atg gag agg ctg act ctg     112
                                          Met Glu Arg Leu Thr Leu
                                            1               5

 acc agg aca att ggg ggc cct ctc ctt aca gct aca ctc cta ggg aag      160
 Thr Arg Thr Ile Gly Gly Pro Leu Leu Thr Ala Thr Leu Leu Gly Lys
              10                  15                  20

 acc acc atc aat gat tac cag gtg atc agg atg ccc ttc tgt cat ctg      208
 Thr Thr Ile Asn Asp Tyr Gln Val Ile Arg Met Pro Phe Cys His Leu
          25                  30                  35

 tct acc tac agc ctg gtt tgg gtc atg gca gca gtg gtg ctg tgc aca      256
 Ser Thr Tyr Ser Leu Val Trp Val Met Ala Ala Val Val Leu Cys Thr
      40                  45                  50

 gca caa gtg caa gtg gtg acc cag gat gaa aga gag cag ctg tac aca      304
 Ala Gln Val Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr
  55                  60                  65                  70

 cct gct tcc tta aaa tgc tct ctg caa aat gcc cag gaa gcc ctc att      352
 Pro Ala Ser Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile
                  75                  80                  85

 gtg aca tgg cag aaa aag aaa gct gta agc cca gaa aac atg gtc acc      400
 Val Thr Trp Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr
              90                  95                 100

 ttc agc gag aac cat ggg gtg gtg atc cag cct gcc tat aag gac aag      448
 Phe Ser Glu Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys
         105                 110                 115

 ata aac att acc cag ctg gga ctc caa aac tca acc atc acc ttc tgg      496
 Ile Asn Ile Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp
     120                 125                 130

 aat atc acc ctg gag gat gaa ggg tgt tac atg tgt ctc ttc aat acc      544
 Asn Ile Thr Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr
 135                 140                 145                 150

 ttt ggt ttt ggg aag atc tca gga acg gcc tgc ctc acc gtc tat gta      592
 Phe Gly Phe Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val
                 155                 160                 165

 cag ccc ata gta tcc ctt cac tac aaa ttc tct gaa gac cac cta aat      640
 Gln Pro Ile Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn
             170                 175                 180

 atc act tgc tct gcc act gcc cgc cca gcc ccc atg gtc ttc tgg aag      688
 Ile Thr Cys Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys
         185                 190                 195

 gtc cct cgg tca ggg att gaa aat agt aca gtg act ctg tct cac cca      736
 Val Pro Arg Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro
     200                 205                 210

 aat ggg acc aca tct gtt acc agc atc ctc cat atc aaa gac cct aag      784
 Asn Gly Thr Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys
 215                 220                 225                 230

 aat cag gtg ggg aag gag gtg atc tgc cag gtg ctg cac ctg ggg act      832
 Asn Gln Val Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr
                 235                 240                 245

 gtg acc gac ttt aag caa acc gtc aac aaa ggc tat tgg ttt tca gtt      880
 Val Thr Asp Phe Lys Gln Thr Val Asn Lys Gly Tyr Trp Phe Ser Val
             250                 255                 260

 ccg cta ttg cta agc att gtt tcc ctg gta att ctt ctc gtc cta atc      928
 Pro Leu Leu Leu Ser Ile Val Ser Leu Val Ile Leu Leu Val Leu Ile
         265                 270                 275

 tca atc tta ctg tac tgg aaa cgt cac cgg aat cag gac cga gag ccc      976
 Ser Ile Leu Leu Tyr Trp Lys Arg His Arg Asn Gln Asp Arg Glu Pro 
     280                 285                 290

 taaataagtc acacagcacc ctgaaagtga ttccctggtc tacttgaatt tgacacaaga   1036

 gaaaagcagg aggaaaaggg gccattctcc aaaggacctg aaagagcaaa agaggtggga   1096

 gcgaaagcct taaggatccc acgacttttt actgccatct gagctactca gtgtttgaat   1156

 cccaagagga agcagtttac ctctcaagtc tgttgtagga cttgattttg              1206




      <210> 109
      <211> 1273
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (251)..(1189)

      <400> 109
 tccgggtcga cccacgcgtc cggagcgggg cgtgggacgt gctgcggcgt cctagctggc     60

 ttacagggcg gcggcggggt gtgtgtcctc tgttaagagt gctactcgcc cggggttgat    120

 ctgtgcatgc cactcctggg tcagacggtg aggtcggcgt ctgcgaggac gcggcggtgg    180

 agtagaaggg cagccggaga caggcccggc gccccttccg aggctagacg gccccagctt    240

 cgcggggatc   atg gca ttg ctg gtg gac cga gtg cgg ggc cac tgg cga     289
              Met Ala Leu Leu Val Asp Arg Val Arg Gly His Trp Arg
                1               5                  10

 atc gcc gcc ggg ctc ctg ttc aac ctg ctg gtg tcc atc tgc att gtg      337
 Ile Ala Ala Gly Leu Leu Phe Asn Leu Leu Val Ser Ile Cys Ile Val
      15                  20                  25

 ttc ctc aac aaa tgg att tat gtg tac cac ggc ttc ccc aac atg agc      385
 Phe Leu Asn Lys Trp Ile Tyr Val Tyr His Gly Phe Pro Asn Met Ser
  30                  35                  40                  45

 ctg acc ctg gtg cac ttc gtg gtc acc tgg ctg ggc ttg tat atc tgc      433
 Leu Thr Leu Val His Phe Val Val Thr Trp Leu Gly Leu Tyr Ile Cys
                  50                  55                  60

 cag aag ctg gac atc ttt gcc ccc aaa agt ctg ccg ccc tcc agg ctc      481
 Gln Lys Leu Asp Ile Phe Ala Pro Lys Ser Leu Pro Pro Ser Arg Leu
              65                  70                  75

 ctc ctc ctg gcc ctc agc ttc tgt ggc ttt gtg gtc ttc act aac ctt      529
 Leu Leu Leu Ala Leu Ser Phe Cys Gly Phe Val Val Phe Thr Asn Leu
          80                  85                  90

 tct ctg cag aac aac acc ata ggc acc tat cag ctg gcc aag gcc atg      577
 Ser Leu Gln Asn Asn Thr Ile Gly Thr Tyr Gln Leu Ala Lys Ala Met
      95                 100                 105

 acc acg ccg gtg atc ata gcc atc cag acc ttc tgc tac cag aaa acc      625
 Thr Thr Pro Val Ile Ile Ala Ile Gln Thr Phe Cys Tyr Gln Lys Thr
 110                 115                 120                 125

 ttc tcc acc aga atc cag ctc acg ctg att cct ata act tta ggt gta      673
 Phe Ser Thr Arg Ile Gln Leu Thr Leu Ile Pro Ile Thr Leu Gly Val
                 130                 135                 140

 atc cta aat tct tat tac gat gtg aag ttt aat ttc ctt gga atg gtg      721
 Ile Leu Asn Ser Tyr Tyr Asp Val Lys Phe Asn Phe Leu Gly Met Val
             145                 150                 155

 ttt gct gct ctt ggt gtt tta gtt aca tcc ctt tat caa gtg tgg gta      769
 Phe Ala Ala Leu Gly Val Leu Val Thr Ser Leu Tyr Gln Val Trp Val
         160                 165                 170

 gga gcc aaa cag cat gaa tta caa gtg aac tca atg cag ctg ctg tac      817
 Gly Ala Lys Gln His Glu Leu Gln Val Asn Ser Met Gln Leu Leu Tyr
     175                 180                 185

 tac cag gct ccg atg tca tct gcc atg ttg ctg gtt gct gtg ccc ttc      865
 Tyr Gln Ala Pro Met Ser Ser Ala Met Leu Leu Val Ala Val Pro Phe
 190                 195                 200                 205

 ttt gag cca gtg ttt gga gaa gga gga ata ttt ggt ccc tgg tca gtt      913
 Phe Glu Pro Val Phe Gly Glu Gly Gly Ile Phe Gly Pro Trp Ser Val
                 210                 215                 220

 tct gct ttg ctt atg gtg ctg cta tct gga gta ata gct ttc atg gtg      961
 Ser Ala Leu Leu Met Val Leu Leu Ser Gly Val Ile Ala Phe Met Val
             225                 230                 235

 aac tta tca att tat tgg atc att ggg aac act tca cct gtc acc tat     1009
 Asn Leu Ser Ile Tyr Trp Ile Ile Gly Asn Thr Ser Pro Val Thr Tyr
         240                 245                 250

 aac atg ttc gga cac ttc aag ttc tgc att act tta ttc gga gga tat     1057
 Asn Met Phe Gly His Phe Lys Phe Cys Ile Thr Leu Phe Gly Gly Tyr
     255                 260                 265

 gtt tta ttt aag gat cca ctg tcc att aat cag gcc ctt ggc att tta     1105
 Val Leu Phe Lys Asp Pro Leu Ser Ile Asn Gln Ala Leu Gly Ile Leu
 270                 275                 280                 285

 tgt aca tta ttt ggc att ctc gcc tat acc cac ttt aag ctc agt gaa     1153
 Cys Thr Leu Phe Gly Ile Leu Ala Tyr Thr His Phe Lys Leu Ser Glu
                 290                 295                 300

 cag gaa gga agt agg agt aaa ctg gca caa cgt cct taat tgggtttttg     1203
 Gln Glu Gly Ser Arg Ser Lys Leu Ala Gln Arg Pro 
             305                 310

 tggagaaaag aatgttgtcc caagaagata aaaaatattg ttaagtgtgc aagttattaa   1263

 aaaaaaaaaa                                                          1273




      <210> 110
      <211> 644
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (26)..(364)

      <400> 110
 tttttttttt ttttttttca catct  atg gaa cac ttt att tta aat tct ttt      52
                              Met Glu His Phe Ile Leu Asn Ser Phe
                                1               5

 aat aat att att att ttt cag ctg agt ctg ggt ctc act ctg tcg ccc      100
 Asn Asn Ile Ile Ile Phe Gln Leu Ser Leu Gly Leu Thr Leu Ser Pro
  10                  15                  20                  25

 agg ctg gaa tgc agt ggc atg atc aca gct cac tgc ggc ctc caa ctc      148
 Arg Leu Glu Cys Ser Gly Met Ile Thr Ala His Cys Gly Leu Gln Leu
                  30                  35                  40

 ctg ggc tca agt gat tct cct gcc cca gcc tcc cga gta gct ggg act      196
 Leu Gly Ser Ser Asp Ser Pro Ala Pro Ala Ser Arg Val Ala Gly Thr
              45                  50                  55

 aca ggc ttg cgc cac cat gcc cgg ctt ata ggg cac ttt aga tgg aaa      244
 Thr Gly Leu Arg His His Ala Arg Leu Ile Gly His Phe Arg Trp Lys
          60                  65                  70

 caa atg act gga tct tta act cct acc ttt ctc tcc tct ctt cct gta      292
 Gln Met Thr Gly Ser Leu Thr Pro Thr Phe Leu Ser Ser Leu Pro Val
      75                  80                  85

 atg ttg tta ctg aag gca gga agg gag act cct tgg cta aag agc aga      340
 Met Leu Leu Leu Lys Ala Gly Arg Glu Thr Pro Trp Leu Lys Ser Arg
  90                  95                 100                 105

 gca aga gcc tca aag tgg tct ttg tgagccaccc tggactactg gttcagtaga     394
 Ala Arg Ala Ser Lys Trp Ser Leu 
                 110

 gggttgagtc aagcaatatt tgaggacggg atataaacag tatttcttaa agttgtcacc    454

 aatttttccc ccgatgaggc cattccagac ccaaattagt cataacagag ccaggacaat    514

 aatcacatct cctgattctg agcctgaatg cttcccacag gactgcgtcg ctcccactgc    574

 tctgaggtcc attgtggggg agagttgcca ctgggattcc acctcaaggc gtggggacca    634

 agacggattc                                                           644




      <210> 111
      <211> 1160
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (362)..(769)

      <400> 111
 gcacgagggg ccctgagggg cgccgagatg tgggagctgc tggccgcggc gtgggcagtt     60

 caggggctgg gcggctgagg gtgcaaatag ctatgggcaa cttggcctcg gccataagga    120

 agatgtgctg ttgccccagc aactgaatga cttctgtaaa cccaggagtg tcaggaggat    180

 cacaggagga gggggccact ctgcagttgt cacagatgga ggagacctct ttgtttgtgg    240

 cctgaacaaa gatgggcaac tggggcttgg tcacacagag gatatcccat attttacccc    300

 ctgcaaatcc ctctttggct gtcccatcca acaggtggcc tgtggctggg attttacgat    360

 t    atg ctc aca gaa aat ggt caa gtt cta tca tgt gga tcc aac tcc     406
      Met Leu Thr Glu Asn Gly Gln Val Leu Ser Cys Gly Ser Asn Ser
        1               5                  10                  15

 ttt ggc cag tta gga gtt cct cat gga cct cga aga tgt gtg gtt ccc      454
 Phe Gly Gln Leu Gly Val Pro His Gly Pro Arg Arg Cys Val Val Pro
                  20                  25                  30

 cag gcc att gag ctc cat aaa gag aag gtt gtt tgt att gct gct gga      502
 Gln Ala Ile Glu Leu His Lys Glu Lys Val Val Cys Ile Ala Ala Gly
              35                  40                  45

 ctg agg cat gca gta gct gct aca ggt cta gag aat tct aaa gca atg      550
 Leu Arg His Ala Val Ala Ala Thr Gly Leu Glu Asn Ser Lys Ala Met
          50                  55                  60

 tgt gtt ctt gct ggc tca gac cac tca gct tca tta aca gat gca gga      598
 Cys Val Leu Ala Gly Ser Asp His Ser Ala Ser Leu Thr Asp Ala Gly
      65                  70                  75

 gag gtg tat gtt tgg gga agc aac aag cat ggg caa ctg gct aat gag      646
 Glu Val Tyr Val Trp Gly Ser Asn Lys His Gly Gln Leu Ala Asn Glu
  80                  85                  90                  95

 gct gct ttc ctt cct gtg ccc cag aaa ata gaa gca cat tgt ttc cag      694
 Ala Ala Phe Leu Pro Val Pro Gln Lys Ile Glu Ala His Cys Phe Gln
                 100                 105                 110

 aat gaa aag gtc act gcc atc tgg agt gga tgg aca cac ctg gtt gct      742
 Asn Glu Lys Val Thr Ala Ile Trp Ser Gly Trp Thr His Leu Val Ala
             115                 120                 125

 cag aca ggt ctc ttg tgg ctc aga gca taatt tggcaataat tggtggagtg      794
 Gln Thr Gly Leu Leu Trp Leu Arg Ala 
         130                 135

 tgttactctt ggggctggaa tgagcatggc atgtgcggag atggcactga agccaacgtc    854

 tgggccccaa agccggtgca ggctctgctg tcatcgtcag gactccttgt gggctgtggg    914

 gctggccact ccttggccct ctgccagctg ccagctcacc ctgcattggt ccaggacccc    974

 aaggtcacct acctttcccc agatgccatc gaggacactg aatctcagaa agccatggac   1034

 aaagagagaa actggaagga aagacaatca gaaacttcaa cccaaagcca atctgactgg   1094

 tccagaaatg ggggactgtg atagagaatc tttaataaag tggcttttcc caccaaaaaa   1154

 aaaaaa                                                              1160




      <210> 112
      <211> 1274
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (362)..(883)

      <400> 112
 gcacgagggg ccctgagggg cgccgagatg tgggagctgc tggccgcggc gtgggcagtt     60

 caggggctgg gcggctgagg gtgcaaatag ctatgggcaa cttggcctcg gccataagga    120

 agatgtgctg ttgccccagc aactgaatga cttctgtaaa cccaggagtg tcaggaggat    180

 cacaggagga gggggccact ctgcagttgt cacagatgga ggagacctct ttgtttgtgg    240

 cctgaacaaa gatgggcaac tggggcttgg tcacacagag gatatcccat attttacccc    300

 ctgcaaatcc ctctttggct gtcccatcca acaggtggcc tgtggctggg attttacgat    360

 t    atg ctc aca gaa aat ggt caa gtt cta tca tgt gga tcc aac tcc     406
      Met Leu Thr Glu Asn Gly Gln Val Leu Ser Cys Gly Ser Asn Ser
        1               5                  10                  15

 ttt ggc cag tta gga gtt cct cat gga cct cga aga tgt gtg gtt ccc      454
 Phe Gly Gln Leu Gly Val Pro His Gly Pro Arg Arg Cys Val Val Pro
                  20                  25                  30

 cag gcc att gag ctc cat aaa gag aag gtt gtt tgt att gct gct gga      502
 Gln Ala Ile Glu Leu His Lys Glu Lys Val Val Cys Ile Ala Ala Gly
              35                  40                  45

 ctg agg cat gca gta gct gct aca gcg agt ggc atc gtg ttc cag tgg      550
 Leu Arg His Ala Val Ala Ala Thr Ala Ser Gly Ile Val Phe Gln Trp
          50                  55                  60

 ggg act ggt ttg gca tca tgt gga cga cgg ttg tgc cct ggg cag act      598
 Gly Thr Gly Leu Ala Ser Cys Gly Arg Arg Leu Cys Pro Gly Gln Thr
      65                  70                  75

 ctt cca ttg ttt ttc aca gca aag gaa cca agc aga gtg aca ggt cta      646
 Leu Pro Leu Phe Phe Thr Ala Lys Glu Pro Ser Arg Val Thr Gly Leu
  80                  85                  90                  95

 gag aat tct aaa gca atg tgt gtt ctt gct ggc tca gac cac tca gct      694
 Glu Asn Ser Lys Ala Met Cys Val Leu Ala Gly Ser Asp His Ser Ala
                 100                 105                 110

 tca tta aca gat gca gga gag gtg tat gtt tgg gga agc aac aag cat      742
 Ser Leu Thr Asp Ala Gly Glu Val Tyr Val Trp Gly Ser Asn Lys His
             115                 120                 125

 ggg caa ctg gct aat gag gct gct ttc ctt cct gtg ccc cag aaa ata      790
 Gly Gln Leu Ala Asn Glu Ala Ala Phe Leu Pro Val Pro Gln Lys Ile
         130                 135                 140

 gaa gca cat tgt ttc cag aat gaa aag gtc act gcc atc tgg agt gga      838
 Glu Ala His Cys Phe Gln Asn Glu Lys Val Thr Ala Ile Trp Ser Gly
     145                 150                 155

 tgg aca cac ctg gtt gct cag aca ggt ctc ttg tgg ctc aga gca taa      886
 Trp Thr His Leu Val Ala Gln Thr Gly Leu Leu Trp Leu Arg Ala 
 160                 165                 170

 tttggcaata attggtggag tgtgttactc ttggggctgg aatgagcatg gcatgtgcgg    946

 agatggcact gaagccaacg tctgggcccc aaagccggtg caggctctgc tgtcatcgtc   1006

 aggactcctt gtgggctgtg gggctggcca ctccttggcc ctctgccagc tgccagctca   1066

 ccctgcattg gtccaggacc ccaaggtcac ctacctttcc ccagatgcca tcgaggacac   1126

 tgaatctcag aaagccatgg acaaagagag aaactggaag gaaagacaat cagaaacttc   1186

 aacccaaagc caatctgact ggtccagaaa tgggggactg tgatagagaa tctttaataa   1246

 agtggctttt cccaccaaaa aaaaaaaa                                      1274




      <210> 113
      <211> 672
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (201)..(305)

      <400> 113
 gcacgagcgg acgtagctgt cgccacctcg cgccgggtcc gccggcccac gggacccccc     60

 actgacgccc ccggcagcgg tccacatgga cgtgcggggc cctgaagccc cggcggcgcg    120

 cgctgcggga cgcggcagaa aatctatttc aggaacttca ggaacatttt caagctctga    180

 cggcaacatt aaacctcaga    atg gaa gaa atg gga aat cgc att gag gac     230
                          Met Glu Glu Met Gly Asn Arg Ile Glu Asp
                            1               5                  10

 tta cag aag aat gtc aat gac tta atg gtg caa gct ggc att gaa aat      278
 Leu Gln Lys Asn Val Asn Asp Leu Met Val Gln Ala Gly Ile Glu Asn
                  15                  20                  25

 tct att aaa gaa caa atg ctg aag acc taact gcagcatgtc tgtatttgga      330
 Ser Ile Lys Glu Gln Met Leu Lys Thr 
              30                  35

 gatggggcct ctacagaagt cattaaggtt acatcggtcc tgagggtggg gccctcatcc    390

 aacaggattc gtctttctga gaagagacgc aaggggctcg cctgctctcc ccccgtgcct    450

 gcaccagaga aggaggccat cggcaagcca aggagagccc tccccagaaa tcacacggac    510

 cagcaccttg atctgggact tccagaaaac agaactgtga aaagacaagt ttctgttgtt    570

 taaaccaccc aatctgaagt attttgttat ggcagtcctg ggcagactaa tacaatatgc    630

 aacacattta caataaatat acaataaact taaaaaaaaa aa                       672




      <210> 114
      <211> 389
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (54)..(236)

      <400> 114
 tgccctgact tctcatatct tgcctaggaa ctccaggctt gtcttggctc caa   atg      56
                                                              Met
                                                                1

 gat ccc aac tgc tcc tgc acc aca ggt ggc tcc tgt gcc tgc gcc ggc      104
 Asp Pro Asn Cys Ser Cys Thr Thr Gly Gly Ser Cys Ala Cys Ala Gly
               5                  10                  15

 tcc tgc aag tgc aaa gag tgc aaa tgt acc tcc tgc aag aag tgc tgc      152
 Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Cys Cys
          20                  25                  30

 tgc tct tgc tgc ccc gtg ggc tgt gcc aag tgt gcc cag ggc tgt gtc      200
 Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly Cys Val
      35                  40                  45

 tgc aaa ggc tca tca gag aag tgc cgc tgc tgt gcc tgat gttgggagag      250
 Cys Lys Gly Ser Ser Glu Lys Cys Arg Cys Cys Ala 
  50                  55                  60

 ccctgctccc agacataaat agagcaacca gtactaacct ggattttttt ttttaactac    310

 cctgaccggt ttgctacatt cttttttcta ttcaatatgt gaaagacaat aaaacacttt    370

 tgacttgaaa aaaaaaaaa                                                 389




      <210> 115
      <211> 2183
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (433)..(1440)

      <220>
      <221> misc_feature
      <222> (1)...(2183)
      <223> n = a,t,c or g

      <400> 115
 atgcgatatc tctgtaactt ctcaattttt ctgtaaactc taactactct atattagtct     60

 ttaaaaaatc gcttatctta cgaatgattt tgaataagcg ttttgggaat gttctagaga    120

 tgaatctcct ccccatgtcc tacgctgggt gaggaagtgt cgggtacccg ggcgacctgt    180

 cctcaggtgt tctaggaacg cggccccatc ccttgtcagc ctctgtctct gtgtggtgag    240

 aaggcgcact ggctcgtgcn tgcgcgaaac tcgcgcacac agaaaagacc aatcaaggac    300

 gggtcattcc cgccccccgc gcgccttttg cgaccgccca ctcgacaggt tgacaaccta    360

 gacagctccc ccggacttgc cttacttttc catctcctcc cacccagcta taccctccca    420

 ctggcggcgc gg    atg gca cgc cgg cgg agc cag cga gtc tgc gcg agc     468
                  Met Ala Arg Arg Arg Ser Gln Arg Val Cys Ala Ser
                    1               5                  10

 ggt ccg agc atg ctc aat agc gcg cgc ggc gcc ccg gag ctt ctc cgc      516
 Gly Pro Ser Met Leu Asn Ser Ala Arg Gly Ala Pro Glu Leu Leu Arg
          15                  20                  25

 gga acc gcg acc aac gcg gag gtc tcg gcg gcc gct gcg gga gcc aca      564
 Gly Thr Ala Thr Asn Ala Glu Val Ser Ala Ala Ala Ala Gly Ala Thr
      30                  35                  40

 gga agt gaa gag ctt ccg ccg gga gac cgc ggc tgc agg aac gga ggc      612
 Gly Ser Glu Glu Leu Pro Pro Gly Asp Arg Gly Cys Arg Asn Gly Gly
  45                  50                  55                  60

 gga agg ggc cct gcg gcg acg acg tcg tcg acg ggg gtg gcc gtg gga      660
 Gly Arg Gly Pro Ala Ala Thr Thr Ser Ser Thr Gly Val Ala Val Gly
                  65                  70                  75

 gct gag cac gga gaa gac tcc ctc tct cgg aag ccg gat ccc gag ccg      708
 Ala Glu His Gly Glu Asp Ser Leu Ser Arg Lys Pro Asp Pro Glu Pro
              80                  85                  90

 ggc agg atg gat cac cac cag ccg ggg act ggg cgc tac cag gtg ctt      756
 Gly Arg Met Asp His His Gln Pro Gly Thr Gly Arg Tyr Gln Val Leu
          95                 100                 105

 ctt aat gaa gag gat aac tca gaa tca tcg gct ata gag cag cca cct      804
 Leu Asn Glu Glu Asp Asn Ser Glu Ser Ser Ala Ile Glu Gln Pro Pro
     110                 115                 120

 act tca aac cca gca ccg cag att gtg cag gct gcg tct tca gca cca      852
 Thr Ser Asn Pro Ala Pro Gln Ile Val Gln Ala Ala Ser Ser Ala Pro
 125                 130                 135                 140

 gca ctt gaa act gac tct tcc cct cca cca tat agt agt att act gtg      900
 Ala Leu Glu Thr Asp Ser Ser Pro Pro Pro Tyr Ser Ser Ile Thr Val
                 145                 150                 155

 gaa gta cct aca act tca gat aca gaa gtt tac ggt gag ttt tat ccc      948
 Glu Val Pro Thr Thr Ser Asp Thr Glu Val Tyr Gly Glu Phe Tyr Pro
             160                 165                 170

 gtg cca cct ccc tat agc gtt gct acc tct ctt cct aca tac gat gaa      996
 Val Pro Pro Pro Tyr Ser Val Ala Thr Ser Leu Pro Thr Tyr Asp Glu
         175                 180                 185

 gct gag aag gct aaa gct gct gca atg gca gct gca gca gca gaa aca     1044
 Ala Glu Lys Ala Lys Ala Ala Ala Met Ala Ala Ala Ala Ala Glu Thr
     190                 195                 200

 tct caa aga att cag gag gaa gag tgt cca cca aga gat gac ttc agt     1092
 Ser Gln Arg Ile Gln Glu Glu Glu Cys Pro Pro Arg Asp Asp Phe Ser
 205                 210                 215                 220

 gat gca gac cag ctc aga gtg ggg aat gat ggc att ttc atg ctg gca     1140
 Asp Ala Asp Gln Leu Arg Val Gly Asn Asp Gly Ile Phe Met Leu Ala
                 225                 230                 235

 ttt ttc atg gca ttt att ttc aac tgg ctt gga ttt tgt tta tcc ttc     1188
 Phe Phe Met Ala Phe Ile Phe Asn Trp Leu Gly Phe Cys Leu Ser Phe
             240                 245                 250

 tgt atc acc aat acc ata gct gga agg tat ggt gct atc tgc gga ttt     1236
 Cys Ile Thr Asn Thr Ile Ala Gly Arg Tyr Gly Ala Ile Cys Gly Phe
         255                 260                 265

 ggc ctt tcc ttg atc aaa tgg atc ctt att gtc agg ttt tct gat tat     1284
 Gly Leu Ser Leu Ile Lys Trp Ile Leu Ile Val Arg Phe Ser Asp Tyr
     270                 275                 280

 ttt act gga tat ttc aat gga cag tat tgg ctt tgg tgg ata ttt ctt     1332
 Phe Thr Gly Tyr Phe Asn Gly Gln Tyr Trp Leu Trp Trp Ile Phe Leu
 285                 290                 295                 300

 gta ctt ggc ctg ctc ctt ttc ttc aga gga ttt gtt aat tat cta aaa     1380
 Val Leu Gly Leu Leu Leu Phe Phe Arg Gly Phe Val Asn Tyr Leu Lys
                 305                 310                 315

 gtc aga aac atg tct gaa agt atg gca gct gct cat aga aca agg tat     1428
 Val Arg Asn Met Ser Glu Ser Met Ala Ala Ala His Arg Thr Arg Tyr
             320                 325                 330

 ttc ttc tta ttg tag agactgcatc aacccgacat tcctttctta taccaatgtg     1483
 Phe Phe Leu Leu 
         335

 aaatttccag atcatctgta aacctacaac tttaatagaa gactactaat aacagaagac   1543

 aaattagtga agaaaagacg gagtttcgaa attgaatggc agggtggttt ttgcttacaa   1603

 gccatttctg ttcattcttt aagtatctat atttcatttg ttttgcacat atgcatatgt   1663

 gcccatttaa gatatttgca tatacttgat agaaaccata aagttgtagc agttaagtcc   1723

 agtcacattt ggttaatcag tgtttgatat aattgaaaga gttgagtgga taaacagtct   1783

 tccagcttgt aaatgccatt gacttctgac ctgacattta gtataataaa aatgaaattc   1843

 ttaaccatgt caaatgattt agtttctggc tcttagactc atctggcagt tctacacatg   1903

 aaacatcttt tgttatataa ggtgtattga aacctgcagt gctgattatt agaaaggatt   1963

 tgtcagattt ttgaacatga tatttacatt attatttagg aaaactcttc ctgtaaataa   2023

 ccatgcataa cttactttct gcaatgtttt cttagaaatt gtgtccagat agctgtcact   2083

 aattgtaaat taagtgaact aaatatatat gtgtatatgt atacacatat atatacacac   2143

 acacatatat atatttagaa acgtgagtgt taaagataga                         2183




      <210> 116
      <211> 1909
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (135)..(941)

      <400> 116
 ctcggcgtcc cccttcagcc ccgcagcccc cgcctccgcc tccgggggcc ggcggaggct     60

 ccgggaacgc cccggggccc agccccatag cccaatcgcc gactacctgc tgctgcccct    120

 agccgagcgc gagc  atg tgt ccc ggg cgc tgt gca tcc aca ctg gga cgc     170
                  Met Cys Pro Gly Arg Cys Ala Ser Thr Leu Gly Arg
                    1               5                  10

 cga gtg cgc tgc aag gtg ttt ccc att aaa cac tac cag gac aaa atc      218
 Arg Val Arg Cys Lys Val Phe Pro Ile Lys His Tyr Gln Asp Lys Ile
          15                  20                  25

 agg cct tac atc cag ctg cca tcg cac agc aac att act ggc att gtg      266
 Arg Pro Tyr Ile Gln Leu Pro Ser His Ser Asn Ile Thr Gly Ile Val
      30                  35                  40

 gaa gtg atc ctt ggg gaa acc aag gcc tat gtc ttc ttt gag aag gac      314
 Glu Val Ile Leu Gly Glu Thr Lys Ala Tyr Val Phe Phe Glu Lys Asp
  45                  50                  55                  60

 ttt ggg gac atg cac tcc tat gtg cga agc cgg aag agg ctg cgg gaa      362
 Phe Gly Asp Met His Ser Tyr Val Arg Ser Arg Lys Arg Leu Arg Glu
                  65                  70                  75

 gag gaa gcc gcc cgg ctc ttc aag cag att gtc tcc gcc gtc gcc cac      410
 Glu Glu Ala Ala Arg Leu Phe Lys Gln Ile Val Ser Ala Val Ala His
              80                  85                  90

 tgc cac cag tca gcc atc gtg ctg ggg gac ctg aag ctt agg aag ttc      458
 Cys His Gln Ser Ala Ile Val Leu Gly Asp Leu Lys Leu Arg Lys Phe
          95                 100                 105

 gtc ttc tcc acg gag gag aga acc cag ctt aga cta gaa agt cta gaa      506
 Val Phe Ser Thr Glu Glu Arg Thr Gln Leu Arg Leu Glu Ser Leu Glu
     110                 115                 120

 gac aca cac ata atg aag ggg gaa gat gat gct ttg tca gac aaa cat      554
 Asp Thr His Ile Met Lys Gly Glu Asp Asp Ala Leu Ser Asp Lys His
 125                 130                 135                 140

 ggc tgc cca gcc tac gtg agc cct gag atc ctc aac acc act ggg acc      602
 Gly Cys Pro Ala Tyr Val Ser Pro Glu Ile Leu Asn Thr Thr Gly Thr
                 145                 150                 155

 tac tcc gga aag gct gcg gac gtt tgg agc ctg ggg gtg atg ctc tac      650
 Tyr Ser Gly Lys Ala Ala Asp Val Trp Ser Leu Gly Val Met Leu Tyr
             160                 165                 170

 acc ctt ctg gtt gga cga tac ccc ttc cat gac tca gac ccc agt gcc      698
 Thr Leu Leu Val Gly Arg Tyr Pro Phe His Asp Ser Asp Pro Ser Ala
         175                 180                 185

 ctt ttc tcc aaa att cgg cgt gga cag ttc tgc att cct gag cac att      746
 Leu Phe Ser Lys Ile Arg Arg Gly Gln Phe Cys Ile Pro Glu His Ile
     190                 195                 200

 tcc ccc aaa gcc agg tgc ctc att cgc agc ctc ttg aga cgg gag ccc      794
 Ser Pro Lys Ala Arg Cys Leu Ile Arg Ser Leu Leu Arg Arg Glu Pro
 205                 210                 215                 220

 tcc gag aga ctc act gcc ccc gag atc cta ctg cac ccc tgg ttt gag      842
 Ser Glu Arg Leu Thr Ala Pro Glu Ile Leu Leu His Pro Trp Phe Glu
                 225                 230                 235

 tcc gtc ttg gaa ccc ggg tac atc gac tca gaa ata gga act tca gac      890
 Ser Val Leu Glu Pro Gly Tyr Ile Asp Ser Glu Ile Gly Thr Ser Asp
             240                 245                 250

 cag att gtt cca gag tac cag gag gac agt gac att agt tcc ttc ttc      938
 Gln Ile Val Pro Glu Tyr Gln Glu Asp Ser Asp Ile Ser Ser Phe Phe
         255                 260                 265

 tgc taat ccccaaaacc tcagaaacct cataattctt aacacctggc atttccattt      995
 Cys 


 ctaaagatgg acaggccctt tggcgtggta ccaaccagat aatgactgca tcaggatgaa   1055

 agctgctgaa ctcggcatgg cgcctcctct tctctgttgg gatgagtgac tttattgatt   1115

 tgagcagcat atgctgtgat tggctgccct gcaaatttgt ttcccttaag gaaccctcac   1175

 caactatctc tgctggattt gggagttccg catcttttgt ggagggcaga gtatggacat   1235

 cttacacccg gtggtcaagt gtgtaataaa cttgagcatt cgaatgggag aaaaagcaaa   1295

 tcgcacaatg acatattttg agtaataacc gtatttttca cagggtgaca aattgggcca   1355

 ataaatctgc catctttgaa ctcatctttg gtggctagac tgctacggca gcttctctga   1415

 tgggaaagtt ccttttttgg cttaacactc accctttctt cacactcaca tttaccaatg   1475

 actctgctcc gtttttggag cagactgttt taagttgctc aggagcctga tggaaccatg   1535

 aaccgagact cttctctgtt tcctgccaag acctcatctg cactaatgcc ttctccctga   1595

 ccttgacact tcccccttta gctataaaag cacttaccag ccgaacgtgg aacagtatca   1655

 caaaagattc catctcccaa cgatttcaga actctgagct cagagagact ccagatttta   1715

 aaaaataatt tgagtgcttg gaaactatta gctttttaag ttccttccaa atatgttagt   1775

 acctaccctt tactttttcc ccaagaccat ctcagggtgg agcattctgt ctaagagaag   1835

 aaagataagg aggctcccac ccacctctcc caagagcaga cattaaacat ctttgtgctt   1895

 tgaaaaaaaa aaaa                                                     1909




      <210> 117
      <211> 519
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (103)..(468)

      <400> 117
 gatcccgaag cagcgctggg agcgtaagtg cgggcagagc actgcgccgt ttgggaacgc     60

 aactttgagg agacagtgcg gtggacttca gtgaagttcc tt   atg act tcc cct     114
                                                  Met Thr Ser Pro
                                                    1

 gaa att gct tcc tta tca tgg ggg caa atg aaa gta aaa ggc tct aat      162
 Glu Ile Ala Ser Leu Ser Trp Gly Gln Met Lys Val Lys Gly Ser Asn
   5                  10                  15                  20

 aca acc tat aag gac tgc aaa gta tgg cca ggg ggt agt cgg act tgg      210
 Thr Thr Tyr Lys Asp Cys Lys Val Trp Pro Gly Gly Ser Arg Thr Trp
                  25                  30                  35

 gat tgg aga gaa aca gga act gag cat tct cct ggt gtg cag cct gca      258
 Asp Trp Arg Glu Thr Gly Thr Glu His Ser Pro Gly Val Gln Pro Ala
              40                  45                  50

 gat gtg aag gaa gtt gtt gag aag ggt gta cag act ctt gtg att ggc      306
 Asp Val Lys Glu Val Val Glu Lys Gly Val Gln Thr Leu Val Ile Gly
          55                  60                  65

 cga ggg atg agt gag gcc ttg aag gtg cct tca tca act gtg gag tac      354
 Arg Gly Met Ser Glu Ala Leu Lys Val Pro Ser Ser Thr Val Glu Tyr
      70                  75                  80

 ctc aag aaa cat ggc att gat gtg cgg gtc ctc cag aca gag cag gca      402
 Leu Lys Lys His Gly Ile Asp Val Arg Val Leu Gln Thr Glu Gln Ala
  85                  90                  95                 100

 gtg aag gag tat aat gcc ttg gtt gcc caa ggg gtc agg gtg gga ggt      450
 Val Lys Glu Tyr Asn Ala Leu Val Ala Gln Gly Val Arg Val Gly Gly
                 105                 110                 115

 gtc ttc cat tcc acc tgc tgatgg agccttaaga ggagaataaa tcactaagtg      504
 Val Phe His Ser Thr Cys 
             120

 cctaaaaaaa aaaaa                                                     519




      <210> 118
      <211> 5884
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (284)..(4426)

      <400> 118
 tttgagcact ctgagatatg cagatcgtgc aaaacaaatt aaatgcaatg ctgttatcaa     60

 tgaggacccc aatgccaaac tggttcgtga attaaaggag gaggtgacac ggctgaagga    120

 ccttcttcgt gctcagggcc tgggagatat tattgatatt gatccattga tcgatgatta    180

 ctctggaagt ggaagcaaat atctgaaaga ttttcagaac aataagcata gatacttgct    240

 agcctctgag aatcaacgcc ctggccattt ttccacagca tcc  atg ggg tcc ctc     295
                                                  Met Gly Ser Leu
                                                    1

 act tca tcc cca tct tcc tgc tca ctc agt agt cag gtg ggc ttg acg      343
 Thr Ser Ser Pro Ser Ser Cys Ser Leu Ser Ser Gln Val Gly Leu Thr
   5                  10                  15                  20

 tct gtg acc agt att caa gag agg atc atg tct aca cct gga gga gag      391
 Ser Val Thr Ser Ile Gln Glu Arg Ile Met Ser Thr Pro Gly Gly Glu
                  25                  30                  35

 gaa gct att gaa cgt tta aag gaa tca gag aag atc att gct gag ttg      439
 Glu Ala Ile Glu Arg Leu Lys Glu Ser Glu Lys Ile Ile Ala Glu Leu
              40                  45                  50

 aat gaa act tgg gaa gag aag ctt cgt aaa aca gag gcc atc aga atg      487
 Asn Glu Thr Trp Glu Glu Lys Leu Arg Lys Thr Glu Ala Ile Arg Met
          55                  60                  65

 gag aga gag gct ttg ttg gct gag atg gga gtt gcc att cgg gaa gat      535
 Glu Arg Glu Ala Leu Leu Ala Glu Met Gly Val Ala Ile Arg Glu Asp
      70                  75                  80

 gga gga acc cta ggg gtt ttc tca cct aaa aag acc cca cat ctt gtt      583
 Gly Gly Thr Leu Gly Val Phe Ser Pro Lys Lys Thr Pro His Leu Val
  85                  90                  95                 100

 aac ctc aat gaa gac cca cta atg tct gag tgc cta ctt tat tac atc      631
 Asn Leu Asn Glu Asp Pro Leu Met Ser Glu Cys Leu Leu Tyr Tyr Ile
                 105                 110                 115

 aaa gat gga att aca agg gtt ggc caa gca gat gct gag cgg cgc cag      679
 Lys Asp Gly Ile Thr Arg Val Gly Gln Ala Asp Ala Glu Arg Arg Gln
             120                 125                 130

 gac ata gtg ctg agc ggg gct cac att aaa gaa gag cat tgt atc ttc      727
 Asp Ile Val Leu Ser Gly Ala His Ile Lys Glu Glu His Cys Ile Phe
         135                 140                 145

 cgg agt gag aga agc aac agc ggg gaa gtt atc gtg acc tta gag ccc      775
 Arg Ser Glu Arg Ser Asn Ser Gly Glu Val Ile Val Thr Leu Glu Pro
     150                 155                 160

 tgt gag cgc tca gaa acc tac gta aat ggc aag agg gtg tcc cag cct      823
 Cys Glu Arg Ser Glu Thr Tyr Val Asn Gly Lys Arg Val Ser Gln Pro
 165                 170                 175                 180

 gtt cag ctg cgc tca gga aac cgt atc atc atg ggt aaa aac cat gtt      871
 Val Gln Leu Arg Ser Gly Asn Arg Ile Ile Met Gly Lys Asn His Val
                 185                 190                 195

 ttc cgc ttt aac cac ccg gaa caa gca cga gct gag cga gag aag act      919
 Phe Arg Phe Asn His Pro Glu Gln Ala Arg Ala Glu Arg Glu Lys Thr
             200                 205                 210

 cct tct gct gag acc ccc tct gag cct gtg gac tgg aca ttt gcc cag      967
 Pro Ser Ala Glu Thr Pro Ser Glu Pro Val Asp Trp Thr Phe Ala Gln
         215                 220                 225

 agg gag ctt ctg gaa aaa caa gga att gat atg aaa caa gag atg gag     1015
 Arg Glu Leu Leu Glu Lys Gln Gly Ile Asp Met Lys Gln Glu Met Glu
     230                 235                 240

 aaa agg cta cag gaa atg gag atc tta tac aaa aag gag aag gaa gaa     1063
 Lys Arg Leu Gln Glu Met Glu Ile Leu Tyr Lys Lys Glu Lys Glu Glu
 245                 250                 255                 260

 gca gat ctt ctt ttg gag cag cag aga ctg gac tat gag agt aaa ttg     1111
 Ala Asp Leu Leu Leu Glu Gln Gln Arg Leu Asp Tyr Glu Ser Lys Leu
                 265                 270                 275

 cag gcc ttg cag aag cag gtt gaa acc cga tct ctg gct gca gaa aca     1159
 Gln Ala Leu Gln Lys Gln Val Glu Thr Arg Ser Leu Ala Ala Glu Thr
             280                 285                 290

 act gaa gag gag gaa gaa gag gaa gaa gtt cct tgg aca cag cat gaa     1207
 Thr Glu Glu Glu Glu Glu Glu Glu Glu Val Pro Trp Thr Gln His Glu
         295                 300                 305

 ttt gag ttg gcc caa tgg gcc ttc cgg aaa tgg aag tct cat cag ttt     1255
 Phe Glu Leu Ala Gln Trp Ala Phe Arg Lys Trp Lys Ser His Gln Phe
     310                 315                 320

 act tca tta cgg gac tta ctc tgg ggc aat gcc gtg tac cta aag gag     1303
 Thr Ser Leu Arg Asp Leu Leu Trp Gly Asn Ala Val Tyr Leu Lys Glu
 325                 330                 335                 340

 gcc aat gcc atc agt gtg gaa ctg aaa aag aag gtg cag ttt cag ttt     1351
 Ala Asn Ala Ile Ser Val Glu Leu Lys Lys Lys Val Gln Phe Gln Phe
                 345                 350                 355

 gtt ctg ctg act gac aca ctg tac tcc cct ttg cct cct gaa tta ctt     1399
 Val Leu Leu Thr Asp Thr Leu Tyr Ser Pro Leu Pro Pro Glu Leu Leu
             360                 365                 370

 ccc act gag atg gaa aaa act cat gag gac agg cct ttc cct cgc aca     1447
 Pro Thr Glu Met Glu Lys Thr His Glu Asp Arg Pro Phe Pro Arg Thr
         375                 380                 385

 gtg gta gca gta gaa gtc cag gat ttg aag aat gga gca aca cac tat     1495
 Val Val Ala Val Glu Val Gln Asp Leu Lys Asn Gly Ala Thr His Tyr
     390                 395                 400

 tgg tct ttg gag aaa ctc aag cag agg ctg gat ttg atg cga gag atg     1543
 Trp Ser Leu Glu Lys Leu Lys Gln Arg Leu Asp Leu Met Arg Glu Met
 405                 410                 415                 420

 tat gat agg gca ggg gag atg gcc tcc agt gcc caa gac gaa agc gaa     1591
 Tyr Asp Arg Ala Gly Glu Met Ala Ser Ser Ala Gln Asp Glu Ser Glu
                 425                 430                 435

 acc act gtg act ggc agc gat ccc ttc tat gat cgg ttc cac tgg ttc     1639
 Thr Thr Val Thr Gly Ser Asp Pro Phe Tyr Asp Arg Phe His Trp Phe
             440                 445                 450

 aaa ctt gtg ggg agc tcc ccc att ttc cac ggc tgt gtg aac gag cgc     1687
 Lys Leu Val Gly Ser Ser Pro Ile Phe His Gly Cys Val Asn Glu Arg
         455                 460                 465

 ctt gcc gac cgc aca ccc tcc ccc act ttt tcc acg gcc gat tcc gac     1735
 Leu Ala Asp Arg Thr Pro Ser Pro Thr Phe Ser Thr Ala Asp Ser Asp
     470                 475                 480

 atc act gag ctg gct gac gag cag caa gat gag atg gag gat ttt gat     1783
 Ile Thr Glu Leu Ala Asp Glu Gln Gln Asp Glu Met Glu Asp Phe Asp
 485                 490                 495                 500

 gat gag gca ttc gtg gat gac gcc ggc tct gac gca ggg acg gag gag     1831
 Asp Glu Ala Phe Val Asp Asp Ala Gly Ser Asp Ala Gly Thr Glu Glu
                 505                 510                 515

 gga tca gat ctc ttc agt gac ggg cat gac ccg ttt tac gac cga tcc     1879
 Gly Ser Asp Leu Phe Ser Asp Gly His Asp Pro Phe Tyr Asp Arg Ser
             520                 525                 530

 cct tgg ttc att tta gtg gga agg gca ttt gtt tac ctg agc aat ctg     1927
 Pro Trp Phe Ile Leu Val Gly Arg Ala Phe Val Tyr Leu Ser Asn Leu
         535                 540                 545

 ctg tat ccc gtg ccc ctg atc cac agg gtg gcc atc gtc agt gag aaa     1975
 Leu Tyr Pro Val Pro Leu Ile His Arg Val Ala Ile Val Ser Glu Lys
     550                 555                 560

 ggt gaa gtg cgg gga ttt ctg cgt gtg gct gta cag gcc atc gca gcg     2023
 Gly Glu Val Arg Gly Phe Leu Arg Val Ala Val Gln Ala Ile Ala Ala
 565                 570                 575                 580

 gat gaa gaa gct cct gat tat ggc tct gga att cga cag tca gga aca     2071
 Asp Glu Glu Ala Pro Asp Tyr Gly Ser Gly Ile Arg Gln Ser Gly Thr
                 585                 590                 595

 gct aaa ata tct ttt gat aat gaa tac ttt aat cag agt gac ttt tcg     2119
 Ala Lys Ile Ser Phe Asp Asn Glu Tyr Phe Asn Gln Ser Asp Phe Ser
             600                 605                 610

 tct gtt gca atg act cgt tct ggt ctg tcc ttg gag gag ttg agg att     2167
 Ser Val Ala Met Thr Arg Ser Gly Leu Ser Leu Glu Glu Leu Arg Ile
         615                 620                 625

 gtg gaa gga cag ggt cag agt tct gag gtc atc act cct cca gaa gaa     2215
 Val Glu Gly Gln Gly Gln Ser Ser Glu Val Ile Thr Pro Pro Glu Glu
     630                 635                 640

 atc agt cga att aat gac ttg gat ttg aag tca agc act ttg ctg gat     2263
 Ile Ser Arg Ile Asn Asp Leu Asp Leu Lys Ser Ser Thr Leu Leu Asp
 645                 650                 655                 660

 ggt aag atg gta atg gaa ggg ttt tct gaa gag att ggc aac cac ctg     2311
 Gly Lys Met Val Met Glu Gly Phe Ser Glu Glu Ile Gly Asn His Leu
                 665                 670                 675

 aaa ctg ggc agt gcc ttc act ttc cga gta aca gtg ttg cag gcc agt     2359
 Lys Leu Gly Ser Ala Phe Thr Phe Arg Val Thr Val Leu Gln Ala Ser
             680                 685                 690

 gga atc ctc cca gag tat gca gat atc ttc tgt cag ttc aac ttt ttg     2407
 Gly Ile Leu Pro Glu Tyr Ala Asp Ile Phe Cys Gln Phe Asn Phe Leu
         695                 700                 705

 cat cgc cat gat gaa gca ttc tcc acg gag ccc ctc aaa aac aat ggc     2455
 His Arg His Asp Glu Ala Phe Ser Thr Glu Pro Leu Lys Asn Asn Gly
     710                 715                 720

 aga gga agt ccc ctg gcc ttt tat cat gtg cag aat att gca gtg gag     2503
 Arg Gly Ser Pro Leu Ala Phe Tyr His Val Gln Asn Ile Ala Val Glu
 725                 730                 735                 740

 atc act gaa tca ttt gtg gat tac atc aaa acc aag cct att gta ttt     2551
 Ile Thr Glu Ser Phe Val Asp Tyr Ile Lys Thr Lys Pro Ile Val Phe
                 745                 750                 755

 gaa gtc ttt ggg cat tat cag cag cac cca ctt cat ctg caa gga cag     2599
 Glu Val Phe Gly His Tyr Gln Gln His Pro Leu His Leu Gln Gly Gln
             760                 765                 770

 gag ctt aac agt ccg cct cag ccg tgc cgc cga ttc ttc cct cca ccc     2647
 Glu Leu Asn Ser Pro Pro Gln Pro Cys Arg Arg Phe Phe Pro Pro Pro
         775                 780                 785

 atg cca ctg tcc aag cca gtt cca gcc acc aag tta aac acg atg agc     2695
 Met Pro Leu Ser Lys Pro Val Pro Ala Thr Lys Leu Asn Thr Met Ser
     790                 795                 800

 aaa acc agc ctt ggc cag agc atg agc aag tat gac ctc ctg gtt tgg     2743
 Lys Thr Ser Leu Gly Gln Ser Met Ser Lys Tyr Asp Leu Leu Val Trp
 805                 810                 815                 820

 ttt gag atc agt gaa ctg gag cct aca gga gag tat atc cca gct gtg     2791
 Phe Glu Ile Ser Glu Leu Glu Pro Thr Gly Glu Tyr Ile Pro Ala Val
                 825                 830                 835

 gtt gac cac aca gca ggc ttg cct tgc cag ggg aca ttt ttg ctt cat     2839
 Val Asp His Thr Ala Gly Leu Pro Cys Gln Gly Thr Phe Leu Leu His
             840                 845                 850

 cag ggc atc cag cga agg atc aca gtg acc att atc cat gag aag ggg     2887
 Gln Gly Ile Gln Arg Arg Ile Thr Val Thr Ile Ile His Glu Lys Gly
         855                 860                 865

 agc gag ctc cat tgg aaa gat gtt cgt gaa ctg gtg gta ggt cgt att     2935
 Ser Glu Leu His Trp Lys Asp Val Arg Glu Leu Val Val Gly Arg Ile
     870                 875                 880

 cgg aat aag cct gag gtg gat gaa gct gca gtt gat gcc atc ctc tcc     2983
 Arg Asn Lys Pro Glu Val Asp Glu Ala Ala Val Asp Ala Ile Leu Ser
 885                 890                 895                 900

 cta aat att att tct gcc aag tac ctg aag tct tcc cac aac tct agc     3031
 Leu Asn Ile Ile Ser Ala Lys Tyr Leu Lys Ser Ser His Asn Ser Ser
                 905                 910                 915

 agg acc ttc tac cgc ttt gag gct gtg tgg gat agc tct ctg cat aac     3079
 Arg Thr Phe Tyr Arg Phe Glu Ala Val Trp Asp Ser Ser Leu His Asn
             920                 925                 930

 tcc ctt ctt ctg aac cga gtg aca ccc tat gga gaa aag atc tac atg     3127
 Ser Leu Leu Leu Asn Arg Val Thr Pro Tyr Gly Glu Lys Ile Tyr Met
         935                 940                 945

 acc ttg tcg gcc tac cta gag ctg gat cat tgc atc cag ccg gct gtc     3175
 Thr Leu Ser Ala Tyr Leu Glu Leu Asp His Cys Ile Gln Pro Ala Val
     950                 955                 960

 atc acc aag gat gtg tgc atg gtc ttc tac tcc cga gat gcc aag atc     3223
 Ile Thr Lys Asp Val Cys Met Val Phe Tyr Ser Arg Asp Ala Lys Ile
 965                 970                 975                 980

 tca cca cca cgc tct ctg cgt agc ctc ttt ggc agc ggc tac tca aag     3271
 Ser Pro Pro Arg Ser Leu Arg Ser Leu Phe Gly Ser Gly Tyr Ser Lys
                 985                 990                 995

 tca cca gat tcg aat cga gtc act ggc att tac gaa ctc agc tta tgc     3319
 Ser Pro Asp Ser Asn Arg Val Thr Gly Ile Tyr Glu Leu Ser Leu Cys
            1000                1005                1010

 aaa atg tca gac aca ggt agt cca ggt atg cag aga agg aga aga aaa     3367
 Lys Met Ser Asp Thr Gly Ser Pro Gly Met Gln Arg Arg Arg Arg Lys
        1015                1020                1025

 atc tta gat acg tca gtg gca tat gtg cgg gga gaa gag aac tta gca     3415
 Ile Leu Asp Thr Ser Val Ala Tyr Val Arg Gly Glu Glu Asn Leu Ala
    1030                1035                1040

 ggc tgg cgg ccc cgt gga gac agc ctc atc ctt gag cac cag tgg gag     3463
 Gly Trp Arg Pro Arg Gly Asp Ser Leu Ile Leu Glu His Gln Trp Glu
1045                1050                1055                1060

 ctg gag aag ctg gag ctc cta cat gag gtg gaa aaa acc cgc cac ttt     3511
 Leu Glu Lys Leu Glu Leu Leu His Glu Val Glu Lys Thr Arg His Phe
                1065                1070                1075

 ttg ctg ctg cgt gag aga ctt ggt gac agc atc ccc aaa tcc ctg agc     3559
 Leu Leu Leu Arg Glu Arg Leu Gly Asp Ser Ile Pro Lys Ser Leu Ser
            1080                1085                1090

 gac tcg tta tcc ccc agc ctc agc agt ggg acc ctc agc acc tcc acc     3607
 Asp Ser Leu Ser Pro Ser Leu Ser Ser Gly Thr Leu Ser Thr Ser Thr
        1095                1100                1105

 agt atc tcc tct cag atc tca acc act acc ttt gaa agc gcc atc aca     3655
 Ser Ile Ser Ser Gln Ile Ser Thr Thr Thr Phe Glu Ser Ala Ile Thr
    1110                1115                1120

 cct agc gag agc agt ggc tat gat tca gga gac atc gaa agc ctg gtg     3703
 Pro Ser Glu Ser Ser Gly Tyr Asp Ser Gly Asp Ile Glu Ser Leu Val
1125                1130                1135                1140

 gac cga gag aaa gag ctg gct acc aag tgc ctg caa ctt ctc acc cac     3751
 Asp Arg Glu Lys Glu Leu Ala Thr Lys Cys Leu Gln Leu Leu Thr His
                1145                1150                1155

 act ttc aac aga gaa ttc agc cag gtg cac ggc agc gtc agt gac tgt     3799
 Thr Phe Asn Arg Glu Phe Ser Gln Val His Gly Ser Val Ser Asp Cys
            1160                1165                1170

 aag ttg tct gat atc tct cca att gga cgg gat ccc tct gag tcc agt     3847
 Lys Leu Ser Asp Ile Ser Pro Ile Gly Arg Asp Pro Ser Glu Ser Ser
        1175                1180                1185

 ttc agc agt gcc acc ctc act ccc tcc tcc acc tgt ccc tct ctg gta     3895
 Phe Ser Ser Ala Thr Leu Thr Pro Ser Ser Thr Cys Pro Ser Leu Val
    1190                1195                1200

 gac tct agg agc aac tct ctg gat cag aag acc cca gaa gcc aat tcc     3943
 Asp Ser Arg Ser Asn Ser Leu Asp Gln Lys Thr Pro Glu Ala Asn Ser
1205                1210                1215                1220

 cgg gcc tct agt ccc tgc cca gaa ttt gaa cag ttt cag att gtc cca     3991
 Arg Ala Ser Ser Pro Cys Pro Glu Phe Glu Gln Phe Gln Ile Val Pro
                1225                1230                1235

 gct gtg gaa aca cca tat ttg gcc cga gca gga aaa aac gaa ttt ctc     4039
 Ala Val Glu Thr Pro Tyr Leu Ala Arg Ala Gly Lys Asn Glu Phe Leu
            1240                1245                1250

 aat ctt gtt cca gat att gaa gaa att aga cca agc tca gtg gtc tct     4087
 Asn Leu Val Pro Asp Ile Glu Glu Ile Arg Pro Ser Ser Val Val Ser
        1255                1260                1265

 aag aaa gga tac ctt cat ttc aag gag cct ctt tac agt aac tgg gct     4135
 Lys Lys Gly Tyr Leu His Phe Lys Glu Pro Leu Tyr Ser Asn Trp Ala
    1270                1275                1280

 aaa cat ttt gtt gtc gtc cgt cgg cct tat gtc ttc atc tat aac agt     4183
 Lys His Phe Val Val Val Arg Arg Pro Tyr Val Phe Ile Tyr Asn Ser
1285                1290                1295                1300

 gac aaa gac cct gtg gag cgt gga atc att aac ctg tcc aca gca cag     4231
 Asp Lys Asp Pro Val Glu Arg Gly Ile Ile Asn Leu Ser Thr Ala Gln
                1305                1310                1315

 gtg gag tac agt gag gac cag cag gcc atg gtg aag aca cca aac acc     4279
 Val Glu Tyr Ser Glu Asp Gln Gln Ala Met Val Lys Thr Pro Asn Thr
            1320                1325                1330

 ttt gct gtc tgc aca aag cac cgt ggg gtc ctt ttg cag gcc ctc aat     4327
 Phe Ala Val Cys Thr Lys His Arg Gly Val Leu Leu Gln Ala Leu Asn
        1335                1340                1345

 gac aaa gac atg aac gac tgg ttg tat gcc ttc aac cca ctt cta gct     4375
 Asp Lys Asp Met Asn Asp Trp Leu Tyr Ala Phe Asn Pro Leu Leu Ala
    1350                1355                1360

 ggc aca ata cgg tca aag ctt tcc cgc aga tgc ccg agc cag tcg aaa     4423
 Gly Thr Ile Arg Ser Lys Leu Ser Arg Arg Cys Pro Ser Gln Ser Lys
1365                1370                1375                1380

 tac taag tgactctgcc gagtgccctc actcgccttc gagagataaa gaaagcgtta     4480
 Tyr 


 cctctcattt ctctttgtga ttcttgacgg tgactcttgt atgtaatcct gtggcttaac   4540

 tacttctccc tccttgtcca gcacttttct agctctcccg ttccccatct ccattgctct   4600

 gtactctttt cttttttctt gtgctgagaa tctcgttagt agcatgtggc ctaacaaaag   4660

 gaaaaaatgt ttttaaacac acacacacac ttgcacccac cacacacaca cacacacaca   4720

 cacacacaaa aactctgagg ggatctggtg aatctccaaa ttattgtggg tgtactttgg   4780

 cttccttttg tatgataggt ccccatcatg accacctctg atgtctgtgc tgctgtcacc   4840

 aggcaccttt gtttttcaag acaacatact ttttttttct tttctctgtt tgtgatatca   4900

 ctttaatttt tcttgggtgg cttagagact aagggaggag acatctggcc tttttagaac   4960

 ctgagaggaa aaaaagagtc tttttttccc ctctgtctct ttttgccatg gctaatccct   5020

 gcatttccat tcagggaaaa ggtggtagtg agcatagaac tgcaacagtt atattctgag   5080

 tcaaagttgg ggctttttac ggcataatta tggaattttt atttactggt agagaggaga   5140

 cgagaggctt tttcagtggg cctgggacag tggctgctct tgactttgtg tgaagggaaa   5200

 tgccaaggat gcttctggtg gacttcaggg gaccccaggg tttggccgtg ggccgtgatg   5260

 gcagcaggcg gtgggatgct tgtagctcct cacagcagga ttcctgccca ctgttttttc   5320

 tctgttggga gggaagctct tttctaggag tgtctcagtt ctgcttttgg cattagtgat   5380

 ggtggtggta cagttggaat tagtgccatg tcatacacaa atgttccaca aggcgggagt   5440

 gtttcacttt ctggtgataa acttgatggt cattgttatg attaagataa tgccgggcag   5500

 gccgggcaca gtggctcacg cctgtaatcc aagcacttgg ggaggccgag gcgggcagat   5560

 cacgagatca ggagttcaag accagcctgg ccaatatgat gaaaccccgt ctctactaaa   5620

 aatacaaaat tagtcgggta tggtggcaca tgcctgtaat tccagctgct tgggagcctg   5680

 aggcaggaga actgcttgaa cccaggaggc agaggttgca gtgagccaag atcgcgctat   5740

 tgcactccag cctgggtgac agagcaagac tctgcctcag aaaagcaaga agtaataata   5800

 atgctgggta gtgaccttgt gattgttaca gctccctttg atcaaagaaa tatagctttc   5860

 aggcataaac cttggaagtc tcct                                          5884




      <210> 119
      <211> 1112
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (40)..(699)

      <400> 119
 gctcgtcgct gcagccggcg gctagcgggc gtccgcgcc   atg gag cgc tac gcg      54
                                              Met Glu Arg Tyr Ala
                                                1               5

 ggc gcc ttg gag gag gtg gcg gac ggt gcc cgg cag cag gag cga cac      102
 Gly Ala Leu Glu Glu Val Ala Asp Gly Ala Arg Gln Gln Glu Arg His
                  10                  15                  20

 tac cag ctg ctg tcg gcg tta cag agc ctg gtg aag gag ttg ccc agc      150
 Tyr Gln Leu Leu Ser Ala Leu Gln Ser Leu Val Lys Glu Leu Pro Ser
              25                  30                  35

 tca ttc cag cag cgc ttg tcc tac acc acg ctg agc gac ctg gcc ctg      198
 Ser Phe Gln Gln Arg Leu Ser Tyr Thr Thr Leu Ser Asp Leu Ala Leu
          40                  45                  50

 gcg ctt ctc gac ggc acc gtg ttc gaa atc gtg cag ggg cta ctg gag      246
 Ala Leu Leu Asp Gly Thr Val Phe Glu Ile Val Gln Gly Leu Leu Glu
      55                  60                  65

 atc cag cac ctc acc gaa aag agc ctg tac aac cag cgc ctg cgc cta      294
 Ile Gln His Leu Thr Glu Lys Ser Leu Tyr Asn Gln Arg Leu Arg Leu
  70                  75                  80                  85

 cag aac gag cat cga gtg ctc agg cag gcg ctg cgg cag aag cac cag      342
 Gln Asn Glu His Arg Val Leu Arg Gln Ala Leu Arg Gln Lys His Gln
                  90                  95                 100

 gaa gcc cag cag gcc tgc cgg ccc cat aac ctg cct gtg ctt cag gcg      390
 Glu Ala Gln Gln Ala Cys Arg Pro His Asn Leu Pro Val Leu Gln Ala
             105                 110                 115

 gct cag cag cga gaa cta gag gcg gtg gag cac cgg atc cgt gag gag      438
 Ala Gln Gln Arg Glu Leu Glu Ala Val Glu His Arg Ile Arg Glu Glu
         120                 125                 130

 cag cgg gcg atg gac cag aag atc gtc ctg gag ctg gac cgg aag gtg      486
 Gln Arg Ala Met Asp Gln Lys Ile Val Leu Glu Leu Asp Arg Lys Val
     135                 140                 145

 gct gac cag cag agc aca ctg gag aag gcg ggg gtg gct ggc ttc tac      534
 Ala Asp Gln Gln Ser Thr Leu Glu Lys Ala Gly Val Ala Gly Phe Tyr
 150                 155                 160                 165

 gtg acc acc aac cca cag gag ctg atg ctg cag atg aac ctg ctg gaa      582
 Val Thr Thr Asn Pro Gln Glu Leu Met Leu Gln Met Asn Leu Leu Glu
                 170                 175                 180

 ctc atc cgg aag ctg cag cag agg ggc tgc tgg gca ggg aag gca gcc      630
 Leu Ile Arg Lys Leu Gln Gln Arg Gly Cys Trp Ala Gly Lys Ala Ala
             185                 190                 195

 ctg ggg cta gga ggt ccc tgg cag ttg cct gct gcc cag tgt gac cag      678
 Leu Gly Leu Gly Gly Pro Trp Gln Leu Pro Ala Ala Gln Cys Asp Gln
         200                 205                 210

 aaa ggc agc cct gtc cca cca ta gccacaggca gcagaagtct gggcagagtt      731
 Lys Gly Ser Pro Val Pro Pro 
     215                 220

 catcttcttg acctttggcc actgccttcc cagctgcccg cagggggttc cccctgctga    791

 ggagagacca ggtggacccc agctgcctgt cacccttcat ctgggacttg ctgtcaaacc    851

 ctaggatagt ctcataaagg ggaggctggg ccagcctgct gctgtctgct tcagggccag    911

 gcagagagtg aggctggggg ttctcacacc ttactccacc gggcacatcc caacctgcac    971

 tggggcccac tcgagtgctt gttctggtct cagccgctcc cttggcagct gcagccccca   1031

 tgcagaagag gctcccaggc ccaagctctg tgtgacccag agaaataaag atgcctcagt   1091

 gtggcccgca aaaaaaaaaa a                                             1112




      <210> 120
      <211> 1601
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (57)..(1043)

      <400> 120
 ggcacgaggt ttccggcgac ggcgcggggg cagctgggaa tccggaatgc tgcccg         56                                                                 
 atg gcc ctg ggt cct cgc tgt ggg gca atc cgg gct tgc aga cga gtt      104
 Met Ala Leu Gly Pro Arg Cys Gly Ala Ile Arg Ala Cys Arg Arg Val
   1               5                  10                  15

 tta gaa aga gcg ttt tcg cta cgt aaa gca cat tcg ata aag gat atg      152
 Leu Glu Arg Ala Phe Ser Leu Arg Lys Ala His Ser Ile Lys Asp Met
              20                  25                  30

 gaa aat act ttg cag ctg gtg aga aat atc ata cct cct ctg tct tcc      200
 Glu Asn Thr Leu Gln Leu Val Arg Asn Ile Ile Pro Pro Leu Ser Ser
          35                  40                  45

 aca aag cac aaa ggg caa gat gga aga ata ggc gta gtt gga ggc tgt      248
 Thr Lys His Lys Gly Gln Asp Gly Arg Ile Gly Val Val Gly Gly Cys
      50                  55                  60

 cag gag tac act gga gcc cca tat ttt gca gca atc tca gct ctc aaa      296
 Gln Glu Tyr Thr Gly Ala Pro Tyr Phe Ala Ala Ile Ser Ala Leu Lys
  65                  70                  75                  80

 gtg ggc gca gac ttg tcc cac gtg ttc tgt gcc agt gcg gcc gca cct      344
 Val Gly Ala Asp Leu Ser His Val Phe Cys Ala Ser Ala Ala Ala Pro
                  85                  90                  95

 gtg att aag gcc tac agc ccg gag ctg atc gtc cac cca gtt ctt gac      392
 Val Ile Lys Ala Tyr Ser Pro Glu Leu Ile Val His Pro Val Leu Asp
             100                 105                 110

 agc ccc aat gct gtt cat gag gtg gag aag tgg ctg ccc cgg ctg cat      440
 Ser Pro Asn Ala Val His Glu Val Glu Lys Trp Leu Pro Arg Leu His
         115                 120                 125

 gct ctt gtc gta gga cct ggc ttg ggt aga gat gat gcg ctt ctc aga      488
 Ala Leu Val Val Gly Pro Gly Leu Gly Arg Asp Asp Ala Leu Leu Arg
     130                 135                 140

 aat gtc cag ggc att ttg gaa gtg tca aag gcc agg gac atc cct gtt      536
 Asn Val Gln Gly Ile Leu Glu Val Ser Lys Ala Arg Asp Ile Pro Val
 145                 150                 155                 160

 gtc atc gac gcg gat ggc ctg tgg ctg gtc gct cag cag ccg gcc ctc      584
 Val Ile Asp Ala Asp Gly Leu Trp Leu Val Ala Gln Gln Pro Ala Leu
                 165                 170                 175

 atc cat ggc tac cgg aag gct gtg ctc act ccc aac cac gtg gag ttc      632
 Ile His Gly Tyr Arg Lys Ala Val Leu Thr Pro Asn His Val Glu Phe
             180                 185                 190

 agc aga ctg tat gac gct gtg ctc aga ggc cct atg gac agc gat gac      680
 Ser Arg Leu Tyr Asp Ala Val Leu Arg Gly Pro Met Asp Ser Asp Asp
         195                 200                 205

 agc cat gga tct gtg cta aga ctc agc caa gcc ctg ggc aac gtg acg      728
 Ser His Gly Ser Val Leu Arg Leu Ser Gln Ala Leu Gly Asn Val Thr
     210                 215                 220

 gtg gtc cag aaa gga gag cgc gac atc ctc tcc aac ggc cag cag gtg      776
 Val Val Gln Lys Gly Glu Arg Asp Ile Leu Ser Asn Gly Gln Gln Val
 225                 230                 235                 240

 ctt gtg tgc agc cag gaa ggc agc agc cgc agg tgt gga ggg caa ggg      824
 Leu Val Cys Ser Gln Glu Gly Ser Ser Arg Arg Cys Gly Gly Gln Gly
                 245                 250                 255

 gac ctc ctg tcg ggc tcc ctg ggc gtc ctg gta cac tgg gcg ctc ctt      872
 Asp Leu Leu Ser Gly Ser Leu Gly Val Leu Val His Trp Ala Leu Leu
             260                 265                 270

 gct gga cca cag aaa aca aat ggg tcc agc cct ctc ctg gtg gcc gcg      920
 Ala Gly Pro Gln Lys Thr Asn Gly Ser Ser Pro Leu Leu Val Ala Ala
         275                 280                 285

 ttt ggc gcc tgc tct ctc acc agg cag tgc aac cac caa gcc ttc cag      968
 Phe Gly Ala Cys Ser Leu Thr Arg Gln Cys Asn His Gln Ala Phe Gln
     290                 295                 300

 aag cac ggt cgc tcc acc acc acc tcc gac atg atc gcc gag gtg ggg     1016
 Lys His Gly Arg Ser Thr Thr Thr Ser Asp Met Ile Ala Glu Val Gly
 305                 310                 315                 320

 gcc gcc ttc agc aag ctc ttt gaa acc tgagc ccgcgcagac cagaagtaaa     1068
 Ala Ala Phe Ser Lys Leu Phe Glu Thr 
                 325

 caggcacctt ggacggggga gagcgtgtgt gtgatgggaa aatccggacc cacgcgtgtg   1128

 ctgaaggcgt acggtgcttg ccagattttc aacttgagca taaattggtt gccattgaga   1188

 atttaagaat ctggaatatt gcagcttttg gttaaactta atgcatggtt ggagatgtta   1248

 tggcgacact aaacaaagta ttcctgaact ttccttagct ccttggtagt aactgggaag   1308

 acagaaatga agaaaatcac atgagaatga agaattcttt agcagctcaa cagagtttct   1368

 cggcctgctc ccagatcggc gaagtttcta cttgttactc tctctgccgg cgcccttcgt   1428

 tcctcctctg cttcccttcc ctagtctttc ctccggcagg gagctgggca ggggtccccg   1488

 ggtgtctccc tgagtcccga ctgcactgac tgggtccatc agaggggtgc ttcgttcttc   1548

 agctcagttc ttttaaagtt gtgactactt ggtggtatct ggtctttggt ttt          1601




      <210> 121
      <211> 1995
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (263)..(1420)

      <400> 121
 aggactcttg gtggggtagc gagggggacg gtcccacgac tgctccgaag ggccgggact     60

 cccagtgggg gcgggacccc cggagtgccc gcctgcggac tcccaagcct ggagcctggg    120

 gagagggtgg gcacctccgt tcccgcacac ccgtccatgg tgtgtgcgcc gagcgtccag    180

 gagccacggc ggtgtcttcc ttgcgcgtct tttacacgtg tgggggtagg ctgctcctcg    240

 gggctgagcc gtggccaggg tt atg gag agg ccc gcc tct ccc cag atg gcg     292
                          Met Glu Arg Pro Ala Ser Pro Gln Met Ala
                            1               5                  10

 tcg tcg agc cct gac tcc cca tgt tcc tgc gac tgc ttt gtc tcc gtg      340
 Ser Ser Ser Pro Asp Ser Pro Cys Ser Cys Asp Cys Phe Val Ser Val
                  15                  20                  25

 ccc ccg gcc tca gcc atc ccg gct gtg atc ttt gcc aag aac tcg gac      388
 Pro Pro Ala Ser Ala Ile Pro Ala Val Ile Phe Ala Lys Asn Ser Asp
              30                  35                  40

 cga ccc cgg gac gag gtg cag gag ggg gtg ttt gtc ccc gca ggc act      436
 Arg Pro Arg Asp Glu Val Gln Glu Gly Val Phe Val Pro Ala Gly Thr
          45                  50                  55

 cac act cct ggg agc cgg ctc cag tgc acc tac att gaa gtg gaa cag      484
 His Thr Pro Gly Ser Arg Leu Gln Cys Thr Tyr Ile Glu Val Glu Gln
      60                  65                  70

 gtg tcg aag acg cac gct gtg att ctg agc cgt cct tct tgg cta tgg      532
 Val Ser Lys Thr His Ala Val Ile Leu Ser Arg Pro Ser Trp Leu Trp
  75                  80                  85                  90

 ggg gct gag atg ggc gcc aac gag cat ggt gtc tgc att ggc aac gag      580
 Gly Ala Glu Met Gly Ala Asn Glu His Gly Val Cys Ile Gly Asn Glu
                  95                 100                 105

 gct gtg tgg acg aag gag cca gtt ggg gag ggg gaa gcc ctg ctg ggc      628
 Ala Val Trp Thr Lys Glu Pro Val Gly Glu Gly Glu Ala Leu Leu Gly
             110                 115                 120

 atg gac cta ctc agg ctg gct ttg gaa cgg agc agc tct gcc cag gag      676
 Met Asp Leu Leu Arg Leu Ala Leu Glu Arg Ser Ser Ser Ala Gln Glu
         125                 130                 135

 gcc ttg cat gtg atc aca ggg tta ctg gag cac tat ggg cag ggg ggc      724
 Ala Leu His Val Ile Thr Gly Leu Leu Glu His Tyr Gly Gln Gly Gly
     140                 145                 150

 aac tgc ctg gag gat gct gcg cca ttc tcc tac cat agc acc ttc ctg      772
 Asn Cys Leu Glu Asp Ala Ala Pro Phe Ser Tyr His Ser Thr Phe Leu
 155                 160                 165                 170

 ctg gct gac cgc act gag gcg tgg gtg ctg gag aca gct ggg agg ctc      820
 Leu Ala Asp Arg Thr Glu Ala Trp Val Leu Glu Thr Ala Gly Arg Leu
                 175                 180                 185

 tgg gct gca cag agg atc cag gag ggg gcc cgc aac atc tcc aac cag      868
 Trp Ala Ala Gln Arg Ile Gln Glu Gly Ala Arg Asn Ile Ser Asn Gln
             190                 195                 200

 ctg agc att ggc acg gac atc tcg gcc caa cac ccg gag ctg cgg act      916
 Leu Ser Ile Gly Thr Asp Ile Ser Ala Gln His Pro Glu Leu Arg Thr
         205                 210                 215

 cat gcc cag gcc aag ggc tgg tgg gat ggg cag ggt gcc ttt gac ttt      964
 His Ala Gln Ala Lys Gly Trp Trp Asp Gly Gln Gly Ala Phe Asp Phe
     220                 225                 230

 gct cag atc ttc tcc ctg acc cag cag cct gtg cgc atg gag gct gcc     1012
 Ala Gln Ile Phe Ser Leu Thr Gln Gln Pro Val Arg Met Glu Ala Ala
 235                 240                 245                 250

 aag gcc cgc ttc cag gca ggg cgg gag ctg ctg cgg caa cgg caa ggg     1060
 Lys Ala Arg Phe Gln Ala Gly Arg Glu Leu Leu Arg Gln Arg Gln Gly
                 255                 260                 265

 ggc atc acg gca gag gtg atg atg ggc atc ctc aga gac aag gag agt     1108
 Gly Ile Thr Ala Glu Val Met Met Gly Ile Leu Arg Asp Lys Glu Ser
             270                 275                 280

 ggt atc tgt atg gac tcg gga ggc ttt cgc acc acg gcc agc atg gtg     1156
 Gly Ile Cys Met Asp Ser Gly Gly Phe Arg Thr Thr Ala Ser Met Val
         285                 290                 295

 tct gtc ctg ccc cag gat ccc acg cag ccc tgc gtg cac ttt ctt acc     1204
 Ser Val Leu Pro Gln Asp Pro Thr Gln Pro Cys Val His Phe Leu Thr
     300                 305                 310

 gcc acg cca gac cca tcc agg tct gtg ttc aaa cct ttc atc ttc ggg     1252
 Ala Thr Pro Asp Pro Ser Arg Ser Val Phe Lys Pro Phe Ile Phe Gly
 315                 320                 325                 330

 gtg ggg gtg gcc cag gcc ccc cag gtg ctg tcc ccc act ttt gga gca     1300
 Val Gly Val Ala Gln Ala Pro Gln Val Leu Ser Pro Thr Phe Gly Ala
                 335                 340                 345

 caa gac cct gtt cgg acc ctg ccc cga ttc cag act cag gta gat cgt     1348
 Gln Asp Pro Val Arg Thr Leu Pro Arg Phe Gln Thr Gln Val Asp Arg
             350                 355                 360

 cgg cat acc ctc tac cgt gga cac cag gca gcc ctg ggg ctg atg gag     1396
 Arg His Thr Leu Tyr Arg Gly His Gln Ala Ala Leu Gly Leu Met Glu
         365                 370                 375

 aga gat cag gta tcc ccc agg gag taggggctac cttgagggga tgatagacct    1450
 Arg Asp Gln Val Ser Pro Arg Glu 
     380                 385

 cccccactcc cagtgggact ctggaaatat gaaggaacta gggagtggaa gagatttcag   1510

 agctggggag aggagttcct cccttcaaag ccagcaactg cctttgggga atgtcggggg   1570

 gtatctcctt tctcctgctt gtgtgaggtg gtacacagtc cccccttcac ctggcgggaa   1630

 gcctgtcccg gacagactca tctcagcttt cccttggggc aggatcgggg gcagcagctc   1690

 cagcagaaac agcaggatct ggagcaggaa ggcctcgagg ccacacaggg gctgctggcc   1750

 ggcgagtggg ccccacccct ctgggagctg ggcagcctct tccaggcctt cgtgaagagg   1810

 gagagccagg cttatgcgta agcttcatag cttctgctgg cctggggtgg acccaggacc   1870

 cctggggcct gggtgccctg agtggtggta aagtggagca atcccttcac gctccttggc   1930

 catgttctga gcggccagct tggcctttgc cttaataaat gtgctttatt ttcaaaaaaa   1990

 aaaaa                                                               1995




      <210> 122
      <211> 2495
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (193)..(1641)

      <400> 122
 acgaggacag gaggctcaag ggggcggagg cggcgttgcc gggctctccg gaaggagacg     60

 tggcggcggt tgggccggtg atacccgggc gctttatagt cccgccgcct cctcctccac    120

 ctcctcctcc tcctcctctc ctcctggagc agaggaggtt gtggcggtgg ctggagaaag    180

 cggcggcgga gg    atg gag gaa gga ggc ggc ggc gta cgg agt ctg gtc     228
                  Met Glu Glu Gly Gly Gly Gly Val Arg Ser Leu Val
                    1               5                  10

 ccg ggc ggg ccg gtg tta ctg gtc ctc tgc ggc ctc ctg gag gcg tcc      276
 Pro Gly Gly Pro Val Leu Leu Val Leu Cys Gly Leu Leu Glu Ala Ser
          15                  20                  25

 ggc ggc ggc cga gcc ctt cct caa ctc agc gat gac atc cct ttc cga      324
 Gly Gly Gly Arg Ala Leu Pro Gln Leu Ser Asp Asp Ile Pro Phe Arg
      30                  35                  40

 gtc aac tgg ccc ggc acc gag ttc tct ctg ccc aca act gga gtt tta      372
 Val Asn Trp Pro Gly Thr Glu Phe Ser Leu Pro Thr Thr Gly Val Leu
  45                  50                  55                  60

 tat aaa gaa gat aat tat gtc atc atg aca act gca cat aaa gaa aaa      420
 Tyr Lys Glu Asp Asn Tyr Val Ile Met Thr Thr Ala His Lys Glu Lys
                  65                  70                  75

 tat aaa tgc ata ctt ccc ctt gtg aca agt ggg gat gag gaa gaa gaa      468
 Tyr Lys Cys Ile Leu Pro Leu Val Thr Ser Gly Asp Glu Glu Glu Glu
              80                  85                  90

 aag gat tat aaa ggc cct aat cca aga gag ctt ttg gag cca cta ttt      516
 Lys Asp Tyr Lys Gly Pro Asn Pro Arg Glu Leu Leu Glu Pro Leu Phe
          95                 100                 105

 aaa caa agc agt tgt tcc tac aga att gag tct tat tgg act tac gaa      564
 Lys Gln Ser Ser Cys Ser Tyr Arg Ile Glu Ser Tyr Trp Thr Tyr Glu
     110                 115                 120

 gta tgt cat gga aaa cac att cgg cag tac cat gaa gag aaa gaa act      612
 Val Cys His Gly Lys His Ile Arg Gln Tyr His Glu Glu Lys Glu Thr
 125                 130                 135                 140

 ggt cag aaa ata aat att cac gag tac tac ctt ggg aat atg ttg gcc      660
 Gly Gln Lys Ile Asn Ile His Glu Tyr Tyr Leu Gly Asn Met Leu Ala
                 145                 150                 155

 aag aac ctt cta ttt gaa aaa gaa cga gaa gca gaa gaa aag gaa aaa      708
 Lys Asn Leu Leu Phe Glu Lys Glu Arg Glu Ala Glu Glu Lys Glu Lys
             160                 165                 170

 tca aat gag att ccc act aaa aat atc gaa ggt cag atg aca cca tac      756
 Ser Asn Glu Ile Pro Thr Lys Asn Ile Glu Gly Gln Met Thr Pro Tyr
         175                 180                 185

 tat cct gtg gga atg gga aat ggt aca cct tgt agt ttg aaa cag aac      804
 Tyr Pro Val Gly Met Gly Asn Gly Thr Pro Cys Ser Leu Lys Gln Asn
     190                 195                 200

 cgg ccc aga tca agt act gtg atg tac ata tgt cat cct gaa tct aag      852
 Arg Pro Arg Ser Ser Thr Val Met Tyr Ile Cys His Pro Glu Ser Lys
 205                 210                 215                 220

 cat gaa att ctt tca gta gct gaa gtt aca act tgt gaa tat gaa gtt      900
 His Glu Ile Leu Ser Val Ala Glu Val Thr Thr Cys Glu Tyr Glu Val
                 225                 230                 235

 gtc att ttg aca cca ctc ttg tgc agt cat cct aaa tat agg ttc aga      948
 Val Ile Leu Thr Pro Leu Leu Cys Ser His Pro Lys Tyr Arg Phe Arg
             240                 245                 250

 gca tct cct gtg aat gac ata ttt tgt caa tca ctg cca gga tct cca      996
 Ala Ser Pro Val Asn Asp Ile Phe Cys Gln Ser Leu Pro Gly Ser Pro
         255                 260                 265

 ttt aag ccc ctc acc ctg agg cag ctg gag cag cag gaa gaa ata cta     1044
 Phe Lys Pro Leu Thr Leu Arg Gln Leu Glu Gln Gln Glu Glu Ile Leu
     270                 275                 280

 agg gtg cct ttt agg aga aat aaa gag gaa gat ttg caa tca act aaa     1092
 Arg Val Pro Phe Arg Arg Asn Lys Glu Glu Asp Leu Gln Ser Thr Lys
 285                 290                 295                 300

 gaa gag aga ttt cca gcg atc cac aag tcg att gct att ggc tct cag     1140
 Glu Glu Arg Phe Pro Ala Ile His Lys Ser Ile Ala Ile Gly Ser Gln
                 305                 310                 315

 cca gtg ctc act gtt ggg aca acc cac ata tcc aaa ttg aca gat gac     1188
 Pro Val Leu Thr Val Gly Thr Thr His Ile Ser Lys Leu Thr Asp Asp
             320                 325                 330

 caa ctc ata aaa gag ttt ctt agt ggt tct tac tgc ttt cgt ggg ggt     1236
 Gln Leu Ile Lys Glu Phe Leu Ser Gly Ser Tyr Cys Phe Arg Gly Gly
         335                 340                 345

 gtc ggt tgg tgg aaa tat gaa ttc tgc tat ggc aaa cat gta cat caa     1284
 Val Gly Trp Trp Lys Tyr Glu Phe Cys Tyr Gly Lys His Val His Gln
     350                 355                 360

 tac cat gag gac aag gat agt ggg aaa acc tct gtg gtt gtc ggg aca     1332
 Tyr His Glu Asp Lys Asp Ser Gly Lys Thr Ser Val Val Val Gly Thr
 365                 370                 375                 380

 tgg aac caa gaa gag cat att gaa tgg gct aag aag aat act gct aga     1380
 Trp Asn Gln Glu Glu His Ile Glu Trp Ala Lys Lys Asn Thr Ala Arg
                 385                 390                 395

 gct tat cat ctt caa gac gat ggt acc cag aca gtc agg atg gtg tca     1428
 Ala Tyr His Leu Gln Asp Asp Gly Thr Gln Thr Val Arg Met Val Ser
             400                 405                 410

 cat ttt tat gga aat gga gat att tgt gat ata act gac aaa cca aga     1476
 His Phe Tyr Gly Asn Gly Asp Ile Cys Asp Ile Thr Asp Lys Pro Arg
         415                 420                 425

 cag gtg act gta aaa cta aag tgc aaa gaa tca gat tca cct cat gct     1524
 Gln Val Thr Val Lys Leu Lys Cys Lys Glu Ser Asp Ser Pro His Ala
     430                 435                 440

 gtt act gta tat atg cta gag cct cac tcc tgt caa tat att ctt ggg     1572
 Val Thr Val Tyr Met Leu Glu Pro His Ser Cys Gln Tyr Ile Leu Gly
 445                 450                 455                 460

 gtt gaa tct cca gtg atc tgt aaa atc tta gat aca gca gat gaa aat     1620
 Val Glu Ser Pro Val Ile Cys Lys Ile Leu Asp Thr Ala Asp Glu Asn
                 465                 470                 475

 gga ctt ctt tct ctc ccc aac ta aaggatatta aagttagggg aaagaaaaga     1673
 Gly Leu Leu Ser Leu Pro Asn 
             480

 tcattgaaag tcatgataat ttctgtccca ctgtgtctca ttatagagtt ctcagccatt   1733

 ggacctcttc taaaggatgg tataaaatga ctctcaacca ctttgtgaat acatatgtgt   1793

 atataagagg ttattgataa acttctgagg cagacatttg tctcgctttt tttcattttt   1853

 gttgtgtctt ataaactgac tgtttttctt tgcttggata ctgtgattcc aaaataaatc   1913

 tcatccaagc aagttagagt ccagcctaat caaatgtcat aattgttgta cctattgaaa   1973

 gtttttaaat aatagattta ttatgtaaat tatagtatat gtaagtagct aatgaagtaa   2033

 agatcatgaa gaaagaaatt gataggtgta aatgagagac catgtaaaat atgtaaattc   2093

 tagtacctga aatcctttca acagattttt atatagcaac tgctctctgc aagtagttaa   2153

 actagaaact gggcacatgg tagaggctca catgggagtt gtcctcaccc ttgttaatct   2213

 caagaaactc ttatttataa taggttgctt ctctctcaga acttttatct attacttttt   2273

 tcttcttatg agtatgttta ctctcagagt atctatctga tgtagacagt tggtgatgct   2333

 tctgagactc agaatggttt actctaacaa aacactgtgc tgtctatccc ttgtacttgc   2393

 ctactgtaat atggatttca cttctgaaca gtttacagca caatatttat tttaaagtga   2453

 ataaaatgtc cacaagcagt gttgtcatgt aaaaaaaaaa aa                      2495




      <210> 123
      <211> 809
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (202)..(462)

      <400> 123
 ggaaatgacc cgaactgcca gcctgcgcct ttgcagccgg ccctcgcttt gctgaagacg     60

 agcagctccc accaaagtct tgcctcccct taccccgaaa gccccgctca gttcaatatt    120

 tcaagtgaaa atctgcctgt tcgaaaagaa aatattcaca aatgagcagt gtattagaag    180

 acaactgaat tgcttctaag a  atg ggt ctc act ctg cca tca ccc agg ctg     231
                          Met Gly Leu Thr Leu Pro Ser Pro Arg Leu
                            1               5                  10

 gag tgt ggt ggc acc atc atg gct cac tgc agc ctt gaa ctc ctg agc      279
 Glu Cys Gly Gly Thr Ile Met Ala His Cys Ser Leu Glu Leu Leu Ser
                  15                  20                  25

 tca agt cat cct ccc acc tca gcc ttc cga gta gct gga act gca ggt      327
 Ser Ser His Pro Pro Thr Ser Ala Phe Arg Val Ala Gly Thr Ala Gly
              30                  35                  40

 gtg agc cac cat gcc tgg ctg att tgt ctt ttt aaa ttt ttt ata gag      375
 Val Ser His His Ala Trp Leu Ile Cys Leu Phe Lys Phe Phe Ile Glu
          45                  50                  55

 acc gag tct caa cta tat tgt cca ggc tgg aaa aga act tct ttc cct      423
 Thr Glu Ser Gln Leu Tyr Cys Pro Gly Trp Lys Arg Thr Ser Phe Pro
      60                  65                  70

 cca agt gat aac ctt ttc cag aca agt cag ctt aaa aac tgacccaaag       472
 Pro Ser Asp Asn Leu Phe Gln Thr Ser Gln Leu Lys Asn 
  75                  80                  85

 gccctgaagt acacagtttt cttggagaaa gaaaaaaata agtgaaaagg acttgctgac    532

 ttgctaattc attttggggc ctgtgggtaa catcagaatg gcaaagcact tggggctttt    592

 tttctaattt gtattttttt aatcttctga gaaatgactt ttatatgcca agattcattc    652

 catgattagt ttttatgacc aagttatgaa cgcttttgaa tatggggacc tagaatagaa    712

 atgctaacct acctgcaagg agagctctgt gattggcatc cccatcatgc tgtaactgac    772

 acaaaataaa cttagggtaa ttgccaaaaa aaaaaaa                             809




      <210> 124
      <211> 865
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (80)..(280)

      <220>
      <221> misc_feature
      <222> (1)...(865)
      <223> n = a,t,c or g

      <400> 124
 aggatactct ccaaaaagtt cgagaaaatc tagatagacg ctaacaggaa ttggaaaata     60

 acacccctgg taccaaaac atg ttt aac tgg aat cta tgg cta act act cta     112
                      Met Phe Asn Trp Asn Leu Trp Leu Thr Thr Leu
                        1               5                  10

 atc act gga ttg gcg gga ccc ctt ctc ctc ctc ttg tta ggt tta gtc      160
 Ile Thr Gly Leu Ala Gly Pro Leu Leu Leu Leu Leu Leu Gly Leu Val
              15                  20                  25

 ttc ggg cct tgt ata tta aat tgg ttt ctt aaa ttt ata aag cag ttc      208
 Phe Gly Pro Cys Ile Leu Asn Trp Phe Leu Lys Phe Ile Lys Gln Phe
          30                  35                  40

 ata gct tct gtc aaa ctt acg tat ctt aaa acc caa tat aac tcc ctt      256
 Ile Ala Ser Val Lys Leu Thr Tyr Leu Lys Thr Gln Tyr Asn Ser Leu
      45                  50                  55

 gtt gtg act gaa gaa tca atg att tgattaccca aaacatgagt ggggaatgtg     310
 Val Val Thr Glu Glu Ser Met Ile 
  60                  65

 atacctaccc tattttaacc tgccccaagt ttacgtgtac agtgggtcag aagggtgact    370

 tctgaccctt ctgctcagag tgactctctc ttagctgaga tagctggaca ctctccattt    430

 tagcttcttc acttgcagtc cccttatccc cctcccttaa gggaataact agtgcaagct    490

 gactccaagc acatccagga atgcacttac tgataagata ttgaggcaag ctgtaccagc    550

 agctcctggg gacgtgctcg gcggatggta cccaagcccc tgcatttatc tctttgtgat    610

 agtttaagcc cctgcacctg gaactgtatt tttctgtaac tatctctgta accattaatt    670

 tttttaactt tttgcctgtt ctgcttctgt aaaaattgct tcaagtaggc tccccctccc    730

 ctatttagac catggtttaa aaagaaatct atcccgttct tcgaggccaa gagaattttg    790

 agctctagcc atctctcggt cgccggcaat aaaaggactc ctgaattann cnnannnnna    850

 naaaaaaaaa aaaaa                                                     865




      <210> 125
      <211> 369
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (70)..(306)

      <400> 125
 atctggtcga tcgtttcctg gccctcgcct cctgcgctgt gtccctggaa ttcttgcacg     60

 tcgcccaag    atg tct gat gct gac gtt gag aaa gct gcc aag gat gtt     108
              Met Ser Asp Ala Asp Val Glu Lys Ala Ala Lys Asp Val
                1               5                  10

 acg cac ctt aag acc att cct tcg gat gag gag atg ctg ctc atc tat      156
 Thr His Leu Lys Thr Ile Pro Ser Asp Glu Glu Met Leu Leu Ile Tyr
      15                  20                  25

 ggc cac tac tat caa gca act ggg ggc gac ata aat aca gaa cgg gcc      204
 Gly His Tyr Tyr Gln Ala Thr Gly Gly Asp Ile Asn Thr Glu Arg Ala
  30                  35                  40                  45

 ggc atg ttg gac ttc act ggc aat gac acg tgg gat gcc tgg aat gag      252
 Gly Met Leu Asp Phe Thr Gly Asn Asp Thr Trp Asp Ala Trp Asn Glu
                  50                  55                  60

 ctg aaa ggg act tcc aag gaa gat gcc atg cta gct tac atc agc aaa      300
 Leu Lys Gly Thr Ser Lys Glu Asp Ala Met Leu Ala Tyr Ile Ser Lys
              65                  70                  75

 gtt gta tagctattga aaaaatacgg gatattgaga gactggactt gatactgtgc       356
 Val Val 


 catgcgatat gcc                                                       369




      <210> 126
      <211> 5442
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2251)..(2817)

      <400> 126
 atggagaacg tttttactgt gtcatcagat cctcatccct ctcctgcagc ccctccttca     60

 ctttctttac ccttatcttc atcttctacc tcatctggga ctaaaaaaca aaagaggacc    120

 ccaacttatc agagatctat gagctttgat ccaaaccttc tccacaacaa tggacataat    180

 gggtacccta atggtacttc agcagcactg cgtgaaactg gggttattga aaaactgtta    240

 acctcttacg gatttattca gtgttcagaa cgtcaagcta gacttttctt ccactgttca    300

 cagtataatg gcaacctgca agacttaaaa gtaggagatg atgttgaatt tgaagtatca    360

 tcggaccgac ggactgggaa acccattgct gttaaactgg tgaagataaa acaagaaatc    420

 ctccctgaag aacgaatgaa tggacaagaa gtgttttatc tgacttacac ccctgaagat    480

 gtcgaaggga acgttcagct ggaaactgga gataaaataa actttgtaat tgataacaat    540

 aaacatactg gtgctgtaag tgctcgcaac attatgctgt tgaaaaagaa acaagcccgc    600

 tgtcagggag tagtttgtgc catgaaggag gcatttggct ttattgaaag aggtgatgtt    660

 gtaaaagaga tattctttca ctatagtgaa tttaagggtg acttagaaac cttacagcct    720

 ggcgatgatg tggaattcac aatcaaggac agaaatggta aagaagttgc aacagatgtc    780

 agactattgc ctcaaggaac agtcattttt gaagatatca gcattgaaca ttttgaagga    840

 actgtaacca aagttatccc aaaagtaccc agtaaaaacc agaatgaccc attgccagga    900

 cgcatcaaag ttgactttgt gatccctaaa gaacttccct ttggagacaa agatacgaaa    960

 tccaaggtga ccctgctgga aggtgaccat gttaggttta atatttcaac agaccgacgt   1020

 gacaaattag agcgagcaac caatatagaa gttctgtcaa atacatttca gttcactaat   1080

 gaagcccgag aaatgggtgt gattgctgcc atgagagatg gttttggttt catcaagtgt   1140

 gtggatcgtg atgttcgtat gttcttccac ttcagtgaaa ttctggatgg gaaccagctc   1200

 catattgcag atgaagtaga gtttactgtg gttcctgttg aatttagtat tagtgacaaa   1260

 cagaggcctg gacagcaggt tgcaacttgt gtgcgacttt taggtcgtaa ttctaactcc   1320

 aagaggctct tgggttatgt ggcaactctg aaggataatt ttggatttat tgaaacagcc   1380

 aatcatgata aggaaatctt tttccattac agtgagttct ctggtgatgt tgatagcctg   1440

 gaactggggg acatggtcga gtatagcttg tccaaaggca aaggcaacaa agtcagtgca   1500

 gaaaaagtga acaaaacaca ctcagtgaat ggcattactg aggaagctga tcccaccatt   1560

 tactctggca aagtaattcg ccccctgagg agtgttgatc caacacagac tgagtaccaa   1620

 ggaatgattg agattgtgga ggagggcgat atgaaaggtg aggtctatcc atttggcatc   1680

 gttgggatgg ccaacaaagg ggattgcctg cagaaagggg agagcgtcaa gttccaattg   1740

 tgtgtcctgg gccaaaatgc acaaactatg gcttacaaca tcacacccct gcgcagggcc   1800

 acagtggaat gtgtgaaaga tcagtttggc ttcattaact atgaagtagg agatagcaag   1860

 aagctctttt tccatgtgaa agaagttcag gatggcattg agctacaggc aggagatgag   1920

 gtggagttct cagtgattct taatcagcgc actggcaagt gcagcgcctg taatgtttgg   1980

 cgagtctgtg agggccccaa ggctgttgca gctcctcgac ctgatcggtt ggtcaatcgc   2040

 ttgaagaata tcactctgga tgatgccagt gctcctcgcc taatggttct tcgtcagcca   2100

 aggggaccag ataactcaat gttttctgtt aatggcgaaa gaatggaagc gaataaagtt   2160

 ttactgattt ttgagacact agcacctagc gctttcatgc acgaggtcca aagcagaggc   2220

 agtggagctt gaggttcttg ctggtgtgaa     atg act gag tac aaa ctg gtg    2271
                                      Met Thr Glu Tyr Lys Leu Val
                                        1               5

 gtg gtt gga gca ggt ggt gtt ggg aaa agc gca ctg aca atc cag cta     2319
 Val Val Gly Ala Gly Gly Val Gly Lys Ser Ala Leu Thr Ile Gln Leu
          10                  15                  20

 atc cag aac cac ttt gta gat gaa tat gat ccc acc ata gag gat tct     2367
 Ile Gln Asn His Phe Val Asp Glu Tyr Asp Pro Thr Ile Glu Asp Ser
      25                  30                  35

 tac aga aaa caa gtg gtt ata gat ggt gaa acc tgt ttg ttg gac ata     2415
 Tyr Arg Lys Gln Val Val Ile Asp Gly Glu Thr Cys Leu Leu Asp Ile
  40                  45                  50                  55

 ctg gat aca gct gga caa gaa gag tac agt gcc atg aga gac caa tac     2463
 Leu Asp Thr Ala Gly Gln Glu Glu Tyr Ser Ala Met Arg Asp Gln Tyr
                  60                  65                  70

 atg agg aca ggc gaa ggc ttc ctc tgt gta ttt gcc atc aat aat agc     2511
 Met Arg Thr Gly Glu Gly Phe Leu Cys Val Phe Ala Ile Asn Asn Ser
              75                  80                  85

 aag tca ttt gcg gat att aac ctc tac agg gag cag att aag cga gta     2559
 Lys Ser Phe Ala Asp Ile Asn Leu Tyr Arg Glu Gln Ile Lys Arg Val
          90                  95                 100

 aaa gac tcg gat gat gta cct atg gtg cta gtg gga aac aag tgt gat     2607
 Lys Asp Ser Asp Asp Val Pro Met Val Leu Val Gly Asn Lys Cys Asp
     105                 110                 115

 ttg cca aca agg aca gtt gat aca aaa caa gcc cac gaa ctg gcc aag     2655
 Leu Pro Thr Arg Thr Val Asp Thr Lys Gln Ala His Glu Leu Ala Lys
 120                 125                 130                 135

 agt tac ggg att cca ttc att gaa acc tca gcc aag acc aga cag ggt     2703
 Ser Tyr Gly Ile Pro Phe Ile Glu Thr Ser Ala Lys Thr Arg Gln Gly
                 140                 145                 150

 gtt gaa gat gct ttt tac aca ctg gta aga gaa ata cgc cag tac cga     2751
 Val Glu Asp Ala Phe Tyr Thr Leu Val Arg Glu Ile Arg Gln Tyr Arg
             155                 160                 165

 atg aaa aaa ctc aac agc agt gat gat ggg act cag ggt tgt atg gga     2799
 Met Lys Lys Leu Asn Ser Ser Asp Asp Gly Thr Gln Gly Cys Met Gly
         170                 175                 180

 ttg cca tgt gtg gtg atg taacaa gatactttta aagttttgtc agaaaagagc     2853
 Leu Pro Cys Val Val Met 
     185

 cactttcaag ctgcactgac accctggtcc tgacttccct ggaggagaag tattcctgtt   2913

 gctgtcttca gtctcacaga gaagctcctg ctacttcccc agctctcagt agtttagtac   2973

 aataatctct atttgagaag ttctcagaat aactacctcc tcacttggct gtctgaccag   3033

 agaatgcacc tcttgttact ccctgttatt tttctgccct gggttcttcc acagcacaaa   3093

 cacacctctg ccaccccagg tttttcatct gaaaagcagt tcatgtctga aacagagaac   3153

 caaaccgcaa acgtgaaatt ctattgaaaa cagtgtcttg agctctaaag tagcaactgc   3213

 tggtgatttt ttttttcttt ttactgttga acttctggga aaagggagcc tctggggagg   3273

 cacggagtct ctggggaaaa gaaggaccca agcagaccta ggatagtgag aagggttgca   3333

 gatagcataa accaaccaaa gaaaacagat ccagagaaag agagagggaa gagaaaaaag   3393

 aaggaaccag agaaaagaag gaagatgaga gagagaacag ttggtcaatt aataaatctc   3453

 tgccacatgg acttgcagaa tcagcatcat attggtgaaa ctgctgtgca gccgtccgtc   3513

 gatgctccaa atatagtttt aatgaccagt gctgggtccc cttctcatgt aactgaccca   3573

 cttagggtta cagttgaaga ttttgaaatt gtttgcaaag gtctgtatcg ggcactatgc   3633

 atacgtgaga aatacatgca gaagtcgttt cagaggttcc ctaaaacccc ttccaaatac   3693

 ttgcggaaca ttgatggtga ggcttgggta gcaaatgaga gcttctatcc agtctttact   3753

 cctcctgtga agaagggaga ggaccccttc cgaacagaca accttcctga aaacctgggc   3813

 tatcacctca aaatgaagga cggtgtagtt tacgtctatc ctaatgaagc agcagtcagc   3873

 aaagatgagc ctaagccact tccttaccca aatctggaca ccttcttaga cgatatgaat   3933

 tttttacttg ctttaattgc tcaaggacct gttaagacct atacccaccg gcgcctgaag   3993

 ttcctctcct ccaagttcca ggtccatcag atgcttaacg agatggacga gttaaaggag   4053

 ctgaaaaaca acccccaccg agatttttat aactgcagga aggtggacac ccatatccat   4113

 gcagccgctt gcatgaacca gaaacatctg ctgcgtttta ttaagaaatc ttaccaaatt   4173

 gatgctgaca gagtggtcta tagcaccaaa gagaagaatc tgaccctaaa ggaacttttt   4233

 gctaaattaa aaatgcatcc ttatgacctg actgttgatt ctctggatgt tcatgctgga   4293

 cgccagacct tccagcgttt tgataagttc aatgacaaat ataatcctgt aggagcaagt   4353

 gagctacggg acctctactt gaagacagac aattacatta atggggaata ttttgccact   4413

 atcatcaagg aggtaggtgc ggacctggtg gaggccaagt accagcatgc tgagccccgc   4473

 ctgtccatct atggccgcag tcctgatgag tggagcaaac tctcctcctg gttcgtctgc   4533

 aatcgcatcc actgccccaa catgacatgg atgatccagg ttcccaggat ctatgatgtg   4593

 ttccgttcca agaatttcct tccacatttt ggaaaaatgc tggagaatat tttcatgcca   4653

 gtgtttgagg ccaccatcaa cccccaggct gacccagaac tcagtgtctt cctcaagcat   4713

 atcactggct ttgacagtgt ggatgatgag tccaaacaca gtggccacat gttctcctcc   4773

 aagagtccca agccccagga gtggacattg gaaaagaatc catcttacac ttactatgcc   4833

 tactacatgt atgcaaacat catggtgctc aacagcctga gaaaggaacg aggcatgaat   4893

 acgtttctgt tccgacctca ctgtggagaa gctggagccc tcacccatct catgacagca   4953

 ttcatgatag cagatgatat ctctcatggc ctaaatttaa aaaagagtcc cgtgctacag   5013

 tacttgtttt tcttagccca aattcccatc gccatgtcac cactaagtaa caatagccta   5073

 tttctagagt atgccaaaaa tccttttttg gatttccttc agaaagggct aatgatctca   5133

 ctgtctacag atgacccaat gcaattccac tttaccaagg agcccctaat ggaagaatat   5193

 gctattgctg cacaagtctt caagctgagc acctgtgata tgtgcgaagt ggcaaggaac   5253

 agtgtcttgc agtgtggaat ttctcatgag gagaaagtaa agtttctggg cgacaattac   5313

 cttgaggaag gccctgctgg aaatgatatc cggaggacaa atgtagccca aatccgcatg   5373

 gcctatcgct atgaaacctg gtgttatgaa ctcaatttaa ttgctgaggg tcttaaatca   5433

 acagaataa                                                           5442




      <210> 127
      <211> 1599
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (203)..(1351)

      <400> 127
 ggctgcattc cagtatggta tcaaaatgtc tgaagggcgg aaaaccaggc gcttcaagga     60

 aaccaatgac aaagcagagc ttgatcgcca gtggaagaag attagtgcaa tcattgagaa    120

 gaggaagaag atggaagctg atggtgtggg tggttccgag gctgactacc ctgcggcggc    180

 gcggctcgca gtccttctca gc atg gac cgc act tgt gag gag agg ccc gct     232
                          Met Asp Arg Thr Cys Glu Glu Arg Pro Ala
                            1               5                  10

 gag gat ggg agc gac gag gag gac cca gac tcc atg gaa gcc cca acc      280
 Glu Asp Gly Ser Asp Glu Glu Asp Pro Asp Ser Met Glu Ala Pro Thr
                  15                  20                  25

 cgg atc cgg gac act ccg gaa gac atc gtg ctg gaa gct ccg gct agt      328
 Arg Ile Arg Asp Thr Pro Glu Asp Ile Val Leu Glu Ala Pro Ala Ser
              30                  35                  40

 ggg ctg gcg ttc cat ccg gcc cgt gac cta ctg gct gca ggg gac gtg      376
 Gly Leu Ala Phe His Pro Ala Arg Asp Leu Leu Ala Ala Gly Asp Val
          45                  50                  55

 gac ggg gac gtg ttc gtc ttt tcc tac tct tgc caa gag gga gaa acc      424
 Asp Gly Asp Val Phe Val Phe Ser Tyr Ser Cys Gln Glu Gly Glu Thr
      60                  65                  70

 aag gag ctc tgg tca tca ggt cac cat ctc aag gcc tgc cga gct gtg      472
 Lys Glu Leu Trp Ser Ser Gly His His Leu Lys Ala Cys Arg Ala Val
  75                  80                  85                  90

 gcc ttc tct gaa gat ggg cag aag ctc att act gtc tcc aag gac aaa      520
 Ala Phe Ser Glu Asp Gly Gln Lys Leu Ile Thr Val Ser Lys Asp Lys
                  95                 100                 105

 gcc atc cat gtt cta gat gtg gag cag ggc caa ctg gaa aga cgt gtt      568
 Ala Ile His Val Leu Asp Val Glu Gln Gly Gln Leu Glu Arg Arg Val
             110                 115                 120

 tcc aag gct cat ggt gcc ccc atc aat agt ctt ctg ctg gtg gat gag      616
 Ser Lys Ala His Gly Ala Pro Ile Asn Ser Leu Leu Leu Val Asp Glu
         125                 130                 135

 aat gtt ctg gcc act ggg gat gac aca ggt ggt atc cgt ctc tgg gac      664
 Asn Val Leu Ala Thr Gly Asp Asp Thr Gly Gly Ile Arg Leu Trp Asp
     140                 145                 150

 cag cgg aag gag ggc ccc tta atg gat atg agg caa cat gaa gag tac      712
 Gln Arg Lys Glu Gly Pro Leu Met Asp Met Arg Gln His Glu Glu Tyr
 155                 160                 165                 170

 atc gca gac atg gct ctg gat cca gcc aaa aag ctg ctg ctg aca gcc      760
 Ile Ala Asp Met Ala Leu Asp Pro Ala Lys Lys Leu Leu Leu Thr Ala
                 175                 180                 185

 agc ggg gat ggc tgc ctt ggc atc ttc aac att aag agg cgt cgg ttt      808
 Ser Gly Asp Gly Cys Leu Gly Ile Phe Asn Ile Lys Arg Arg Arg Phe
             190                 195                 200

 gag ctg ctc tca gaa cct cag tct ggg gac ctg acc tct gtc act ctc      856
 Glu Leu Leu Ser Glu Pro Gln Ser Gly Asp Leu Thr Ser Val Thr Leu
         205                 210                 215

 atg aaa tgg ggg aag aag gta gcc tgt ggc tcc agt gaa ggt acc atc      904
 Met Lys Trp Gly Lys Lys Val Ala Cys Gly Ser Ser Glu Gly Thr Ile
     220                 225                 230

 tac ctc ttc aat tgg aat ggc ttt ggg gcc aca agt gac cgc ttt gcc      952
 Tyr Leu Phe Asn Trp Asn Gly Phe Gly Ala Thr Ser Asp Arg Phe Ala
 235                 240                 245                 250

 ctg aga gct gaa tct atc gac tgc atg gtt cca gtc acc gag agt ctg     1000
 Leu Arg Ala Glu Ser Ile Asp Cys Met Val Pro Val Thr Glu Ser Leu
                 255                 260                 265

 ctg tgt act ggc tcc act gat gga gtc atc agg gct gtg aac atc cta     1048
 Leu Cys Thr Gly Ser Thr Asp Gly Val Ile Arg Ala Val Asn Ile Leu
             270                 275                 280

 ccg aac cga gtg gtg ggc agt gtg ggc cag cac act ggg gag cct gtg     1096
 Pro Asn Arg Val Val Gly Ser Val Gly Gln His Thr Gly Glu Pro Val
         285                 290                 295

 gag gag ctg gcc ctc tcc cac tgt ggc cgc ttc ctg gcc agt agt ggc     1144
 Glu Glu Leu Ala Leu Ser His Cys Gly Arg Phe Leu Ala Ser Ser Gly
     300                 305                 310

 cat gac cag cgc ctc aag ttt tgg gac atg gcc cag ctg cga gct gtg     1192
 His Asp Gln Arg Leu Lys Phe Trp Asp Met Ala Gln Leu Arg Ala Val
 315                 320                 325                 330

 gtg gtg gat gac tac cgt cgg cgc aaa aaa aag gga gga cca ctg cgg     1240
 Val Val Asp Asp Tyr Arg Arg Arg Lys Lys Lys Gly Gly Pro Leu Arg
                 335                 340                 345

 gct ctg agc agc aag act tgg agc acc gat gac ttc ttc gca gga ctg     1288
 Ala Leu Ser Ser Lys Thr Trp Ser Thr Asp Asp Phe Phe Ala Gly Leu
             350                 355                 360

 agg gaa gag gga gaa gac tcc atg gct cag gaa gaa aag gag gag act     1336
 Arg Glu Glu Gly Glu Asp Ser Met Ala Gln Glu Glu Lys Glu Glu Thr
         365                 370                 375

 ggg gat gac agt gac tgaaggaatg aattgaatct tgagacgggt cctcaccagg     1391
 Gly Asp Asp Ser Asp 
     380

 caagagtctt gcttattggg ctgcatcccc agagaggata tgaattattt tttgaaaaga   1451

 cagggttttg ccatcgtcca ggctggagtg cgctggcttg atcttggctc actgcagcct   1511

 caatgtcccc aggctcagat tgtccttcca ccttagcctc tggagcagct gggactacag   1571

 gtgtgcacta ccacaccagg ccctgtat                                      1599




      <210> 128
      <211> 862
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (148)..(516)

      <400> 128
 cagagcggcc cggtcgccgg catggtttct ccgtcctgct gcagccggcg ggaggcagcc     60

 agtccaggcg cccgctagct tcggcggcga cccagacggg gaaagcggaa ggaatgtcgc    120

 gtgcaagcag gcagctggtg tggaaga    atg gcg gtg agc cat tca gtg aag     171
                                  Met Ala Val Ser His Ser Val Lys
                                    1               5

 gag cgg acc atc tct gag aac agc ctg atc atc cta ctg cag ggc ctc      219
 Glu Arg Thr Ile Ser Glu Asn Ser Leu Ile Ile Leu Leu Gln Gly Leu
      10                  15                  20

 cag ggc cgg gta acc act gtg gac ctg cgg gat gag agc gtg gcc cac      267
 Gln Gly Arg Val Thr Thr Val Asp Leu Arg Asp Glu Ser Val Ala His
  25                  30                  35                  40

 gga cgc ata gac aat gtc gat gct ttc atg aac atc cgc ctg gcc aaa      315
 Gly Arg Ile Asp Asn Val Asp Ala Phe Met Asn Ile Arg Leu Ala Lys
                  45                  50                  55

 gtc acc tac acg gac cgt tgg ggg cat cag gtc aag ctg gat gac ctc      363
 Val Thr Tyr Thr Asp Arg Trp Gly His Gln Val Lys Leu Asp Asp Leu
              60                  65                  70

 ttt gtg aca ggc cgc aat gtc cgc tac gtc cac atc cca gat gac gtg      411
 Phe Val Thr Gly Arg Asn Val Arg Tyr Val His Ile Pro Asp Asp Val
          75                  80                  85

 aac atc acc tcg acc att gag cag cag ctg cag att atc cat cgg gtg      459
 Asn Ile Thr Ser Thr Ile Glu Gln Gln Leu Gln Ile Ile His Arg Val
      90                  95                 100

 cga aac ttt ggt ggc aag ggc caa ggc cgg tgg gaa ttt ccc cca aaa      507
 Arg Asn Phe Gly Gly Lys Gly Gln Gly Arg Trp Glu Phe Pro Pro Lys
 105                 110                 115                 120

 aac tgt aag tgaggcc ctcagcaagc cctggcccca actcggagtc ctccagtgat      563
 Asn Cys Lys 


 ctccggagct agttccctgc cctcacaccc tgtctggtac ccgagaagaa agcagggcca    623

 ggccagaagc tggtgtccaa cagacaccac ctgtcaaagc tgcctttcac agggttccac    683

 ctcccagact cactctggga cccagaatcc tatatgtggc cttggggtag gtgacaatcc    743

 ccctttttga tgatctgaat ctctgactta ttgattatgg aacctgtcaa gtagttttca    803

 actctcccag tgaggataat taaacatgct cagcctgagc cacctctaaa aaaaaaaaa     862




      <210> 129
      <211> 623
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (36)..(551)

      <400> 129
 gcttataatt tggctaatta tccaccttaa tcacc   atg aaa att tat aag gat      53
                                          Met Lys Ile Tyr Lys Asp
                                            1               5

 ctt att act gat gat gaa ctt ttc tca gac acc tat ccc atg aaa ctt      101
 Leu Ile Thr Asp Asp Glu Leu Phe Ser Asp Thr Tyr Pro Met Lys Leu
              10                  15                  20

 att gat ggt gta atc tat gaa gta aca gga agg ctt gtc act cgt aaa      149
 Ile Asp Gly Val Ile Tyr Glu Val Thr Gly Arg Leu Val Thr Arg Lys
          25                  30                  35

 gtt gga gat gtc cag tta att ggt tct aac cct tct gct gaa gat gtt      197
 Val Gly Asp Val Gln Leu Ile Gly Ser Asn Pro Ser Ala Glu Asp Val
      40                  45                  50

 gat gaa gga act gaa gaa gca gtt gaa tca gga tgt gat ata gtt ctg      245
 Asp Glu Gly Thr Glu Glu Ala Val Glu Ser Gly Cys Asp Ile Val Leu
  55                  60                  65                  70

 aat cat aga cta caa gaa agt tat gct ttt ggt gat aaa aag gga tac      293
 Asn His Arg Leu Gln Glu Ser Tyr Ala Phe Gly Asp Lys Lys Gly Tyr
                  75                  80                  85

 acc ttg tat ttg aag gaa tat atg aaa agg att gtt gat aag ctt caa      341
 Thr Leu Tyr Leu Lys Glu Tyr Met Lys Arg Ile Val Asp Lys Leu Gln
              90                  95                 100

 gaa acg aat cct tca gaa gta gac aca ttt aaa act aac att aat aaa      389
 Glu Thr Asn Pro Ser Glu Val Asp Thr Phe Lys Thr Asn Ile Asn Lys
         105                 110                 115

 tat atg aag gat gtc ctt gga agg ttc aag gat ctt caa ttc ttt act      437
 Tyr Met Lys Asp Val Leu Gly Arg Phe Lys Asp Leu Gln Phe Phe Thr
     120                 125                 130

 ggt gaa tct aca gac ata gat ggc atg gtc gct ctt ctt gaa tac aga      485
 Gly Glu Ser Thr Asp Ile Asp Gly Met Val Ala Leu Leu Glu Tyr Arg
 135                 140                 145                 150

 gat tta aac ggt gaa agc aga ccc gtg atg atg ttt ttc aag cat ggc      533
 Asp Leu Asn Gly Glu Ser Arg Pro Val Met Met Phe Phe Lys His Gly
                 155                 160                 165

 ctt att caa gaa aaa tgc taatgt attccaattg ttaacacctt ttgttattct      587
 Leu Ile Gln Glu Lys Cys 
             170

 tggaaacaaa ggtctttgaa agccaaaaaa aaaaaa                              623




      <210> 130
      <211> 472
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (24)..(272)

      <400> 130
 gcacgagtaa caaccgagcc aag    atg ttg cgg aat ctg ctg gcc ctt cgt      50
                              Met Leu Arg Asn Leu Leu Ala Leu Arg
                                1               5

 cag att gcc cag agg acc atc agc acc act tca cga agg cat ttt gaa       98
 Gln Ile Ala Gln Arg Thr Ile Ser Thr Thr Ser Arg Arg His Phe Glu
  10                  15                  20                  25

 aac aag gtt cca gag aaa caa aag ctg ttt cag gag gat aat ggg atg      146
 Asn Lys Val Pro Glu Lys Gln Lys Leu Phe Gln Glu Asp Asn Gly Met
                  30                  35                  40

 cca gtt cat ctg aaa ggc ggg gca tct gat gcc ctc ctc tac aga gcc      194
 Pro Val His Leu Lys Gly Gly Ala Ser Asp Ala Leu Leu Tyr Arg Ala
              45                  50                  55

 aca atg gct ctg acg ctt ggt ggc aca gcc tat gcc atc tat ctg tta      242
 Thr Met Ala Leu Thr Leu Gly Gly Thr Ala Tyr Ala Ile Tyr Leu Leu
          60                  65                  70

 gct atg gct gca ttt ccc aag aag cag aac t aatgtcgtca tcccagtctt      293
 Ala Met Ala Ala Phe Pro Lys Lys Gln Asn 
      75                  80

 cacgtggttc agtttcatca acgctcgatg gaccaggaat ctgatgagta actgagctct    353

 tctttgggga tcaatattta ttgatgtgta ttaactgctg ccaataaagc aatccttaac    413

 cattttgtgt ctcccttttc acttgagaat aaattcctgg taataccaaa aaaaaaaaa     472




      <210> 131
      <211> 1187
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (27)..(1064)

      <400> 131
 aattctgctg gcgctgcagc tgcaga atg gtc ggc ggt ggc ggg aag cgc agg      53
                              Met Val Gly Gly Gly Gly Lys Arg Arg
                                1               5

 ccc ggc gga gag ggg ccg cag tgt gaa aaa aca act gat gtg aag aaa      101
 Pro Gly Gly Glu Gly Pro Gln Cys Glu Lys Thr Thr Asp Val Lys Lys
  10                  15                  20                  25

 agt aaa ttc tgt gaa gct gat gtc tcc agt gac ctt cga aaa gaa gta      149
 Ser Lys Phe Cys Glu Ala Asp Val Ser Ser Asp Leu Arg Lys Glu Val
                  30                  35                  40

 gaa aat cat tat aag ctt tct tta cct gaa gat ttc tat cac ttc tgg      197
 Glu Asn His Tyr Lys Leu Ser Leu Pro Glu Asp Phe Tyr His Phe Trp
              45                  50                  55

 aag ttc tgt gaa gaa ctt gat cct gaa aag cca tct gat tca ctt tct      245
 Lys Phe Cys Glu Glu Leu Asp Pro Glu Lys Pro Ser Asp Ser Leu Ser
          60                  65                  70

 gca agc ctt gga ctt caa tta gtt ggt cct tat gat atc ctt gct gga      293
 Ala Ser Leu Gly Leu Gln Leu Val Gly Pro Tyr Asp Ile Leu Ala Gly
      75                  80                  85

 aaa cat aaa acg aag aaa aaa tca aca ggc ctg aat ttt aac ctt cac      341
 Lys His Lys Thr Lys Lys Lys Ser Thr Gly Leu Asn Phe Asn Leu His
  90                  95                 100                 105

 tgg agg ttt tac tat gat cct cct gag ttc cag acc att att att gga      389
 Trp Arg Phe Tyr Tyr Asp Pro Pro Glu Phe Gln Thr Ile Ile Ile Gly
                 110                 115                 120

 gat aat aaa act cag tac cac atg ggg tat ttc agg gat tct cct gat      437
 Asp Asn Lys Thr Gln Tyr His Met Gly Tyr Phe Arg Asp Ser Pro Asp
             125                 130                 135

 gaa ttt cct gta tat gtt ggt ata aat gaa gca aag aaa aat tgt ata      485
 Glu Phe Pro Val Tyr Val Gly Ile Asn Glu Ala Lys Lys Asn Cys Ile
         140                 145                 150

 att gtt cca aat gga gat aat gta ttt gct gca gtc aaa tta ttt ttg      533
 Ile Val Pro Asn Gly Asp Asn Val Phe Ala Ala Val Lys Leu Phe Leu
     155                 160                 165

 acg aaa aaa ctt aaa gaa ata acg gat aaa aag aaa atc aat ctc ttg      581
 Thr Lys Lys Leu Lys Glu Ile Thr Asp Lys Lys Lys Ile Asn Leu Leu
 170                 175                 180                 185

 aaa aac ata gat gaa aaa ctc aca gaa gca gcc aga gaa ttg ggg tac      629
 Lys Asn Ile Asp Glu Lys Leu Thr Glu Ala Ala Arg Glu Leu Gly Tyr
                 190                 195                 200

 tcg ctt gaa cag aga acc gtg aag atg aaa cag aga gat aag aaa gtt      677
 Ser Leu Glu Gln Arg Thr Val Lys Met Lys Gln Arg Asp Lys Lys Val
             205                 210                 215

 gtg aca aag acc ttt cat ggt gca ggc ttg gtt gtt cca gta gat aaa      725
 Val Thr Lys Thr Phe His Gly Ala Gly Leu Val Val Pro Val Asp Lys
         220                 225                 230

 aat gat gtt ggg tac cga gag ctc cct gaa aca gat gct gac ctc aag      773
 Asn Asp Val Gly Tyr Arg Glu Leu Pro Glu Thr Asp Ala Asp Leu Lys
     235                 240                 245

 aga att tgc aag aca ata gtt gag gct gca agt gat gag gag aga cta      821
 Arg Ile Cys Lys Thr Ile Val Glu Ala Ala Ser Asp Glu Glu Arg Leu
 250                 255                 260                 265

 aaa gct ttt gct ccc att cag gaa atg atg act ttt gtg cag ttt gct      869
 Lys Ala Phe Ala Pro Ile Gln Glu Met Met Thr Phe Val Gln Phe Ala
                 270                 275                 280

 aat gat gaa tgt gat tat ggc atg ggg ctt gaa ttg gga atg gat ctc      917
 Asn Asp Glu Cys Asp Tyr Gly Met Gly Leu Glu Leu Gly Met Asp Leu
             285                 290                 295

 ttt tgc tat ggc tca cat tat ttt cat aaa gtt gct ggc cag ctt tta      965
 Phe Cys Tyr Gly Ser His Tyr Phe His Lys Val Ala Gly Gln Leu Leu
         300                 305                 310

 cct ctt gca tat aat ctg ttg aag agg aat ctg ttt gca gaa att att     1013
 Pro Leu Ala Tyr Asn Leu Leu Lys Arg Asn Leu Phe Ala Glu Ile Ile
     315                 320                 325

 gag gag cat ctg gca aac aga agt caa gag aac ata gac caa ctt gct     1061
 Glu Glu His Leu Ala Asn Arg Ser Gln Glu Asn Ile Asp Gln Leu Ala
 330                 335                 340                 345

 gca tgag taaggtggct ttgattggtg tacagtattt caaaggacta gtattaaact     1118
 Ala 


 tgtgattttt gttttgtttt taaggaatac aaaaaataaa catttactaa aaacgttaaa   1178

 aaaaaaaaa                                                           1187




      <210> 132
      <211> 994
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (8)..(844)

      <400> 132
 acgaaag  atg gcg gcg ccc gta agg cgg acg ctg tta ggg gtg gcg ggg      49
          Met Ala Ala Pro Val Arg Arg Thr Leu Leu Gly Val Ala Gly
            1               5                  10

 ggt tgg cgg cgg ttc gag agg ctc tgg gcc ggc agt cta agc tct cgc       97
 Gly Trp Arg Arg Phe Glu Arg Leu Trp Ala Gly Ser Leu Ser Ser Arg
  15                  20                  25                  30

 agc ctg gct ctt gca gcc gca ccc tca agc aac gga tcc cca tgg cgc      145
 Ser Leu Ala Leu Ala Ala Ala Pro Ser Ser Asn Gly Ser Pro Trp Arg
                  35                  40                  45

 ttg ttg ggc gcg ttg tgc ctg cag cgg cca cct gta gtc tcc aag ccg      193
 Leu Leu Gly Ala Leu Cys Leu Gln Arg Pro Pro Val Val Ser Lys Pro
              50                  55                  60

 ttg acc cca ttg cag gaa gag atg gcg tct cta ctg cag cag att gag      241
 Leu Thr Pro Leu Gln Glu Glu Met Ala Ser Leu Leu Gln Gln Ile Glu
          65                  70                  75

 ata gag aga agc ctg tat tca gac cac gag ctt cgt gct ctg gat gaa      289
 Ile Glu Arg Ser Leu Tyr Ser Asp His Glu Leu Arg Ala Leu Asp Glu
      80                  85                  90

 aac cag cga ctg gca aag aag aaa gct gac ctt cat gat gaa gaa gat      337
 Asn Gln Arg Leu Ala Lys Lys Lys Ala Asp Leu His Asp Glu Glu Asp
  95                 100                 105                 110

 gaa cag gat ata ttg ctg gcg caa gat ttg gaa gat atg tgg gag cag      385
 Glu Gln Asp Ile Leu Leu Ala Gln Asp Leu Glu Asp Met Trp Glu Gln
                 115                 120                 125

 aaa ttt cta cag ttc aaa ctt gga gct cgc ata aca gaa gct gat gaa      433
 Lys Phe Leu Gln Phe Lys Leu Gly Ala Arg Ile Thr Glu Ala Asp Glu
             130                 135                 140

 aag aat gac cga aca tcc ctg aac agg aag cta gac agg aac ctt gtc      481
 Lys Asn Asp Arg Thr Ser Leu Asn Arg Lys Leu Asp Arg Asn Leu Val
         145                 150                 155

 ctg tta gtc aga gag aag ttt gga gac cag gat gtt tgg ata ctg ccc      529
 Leu Leu Val Arg Glu Lys Phe Gly Asp Gln Asp Val Trp Ile Leu Pro
     160                 165                 170

 cag gca gag tgg cag cct ggg gag acc ctt cga gga aca gct gaa cga      577
 Gln Ala Glu Trp Gln Pro Gly Glu Thr Leu Arg Gly Thr Ala Glu Arg
 175                 180                 185                 190

 acc ctg gcc aca ctc tca gaa aac aac atg gaa gcc aag ttc cta gga      625
 Thr Leu Ala Thr Leu Ser Glu Asn Asn Met Glu Ala Lys Phe Leu Gly
                 195                 200                 205

 aat gca ccc tgt ggg cac tac aca ttc aag ttc ccc cag gca atg cgg      673
 Asn Ala Pro Cys Gly His Tyr Thr Phe Lys Phe Pro Gln Ala Met Arg
             210                 215                 220

 aca gag agt aac ctc gga gcc aag gtg ttc ttc ttc aaa gca ctg cta      721
 Thr Glu Ser Asn Leu Gly Ala Lys Val Phe Phe Phe Lys Ala Leu Leu
         225                 230                 235

 tta act gga gac ttt tcc cag gct ggg aat aag ggc cat cat gtg tgg      769
 Leu Thr Gly Asp Phe Ser Gln Ala Gly Asn Lys Gly His His Val Trp
     240                 245                 250

 gtc act aag gat gag ctg ggt gac tat ttg aaa cca aaa tac ctg gcc      817
 Val Thr Lys Asp Glu Leu Gly Asp Tyr Leu Lys Pro Lys Tyr Leu Ala
 255                 260                 265                 270

 caa gtt agg agg ttt gtt tca gac ctc tgatg ggccgagctg cctgtggacg      869
 Gln Val Arg Arg Phe Val Ser Asp Leu 
                 275

 gtgctcagac aagtctggga ttagagcctc aaggacattg tgtgattgcc tcacatttgc    929

 aggtaatatc aagcagcaaa ctaaattctg agaaataaac gagtctatta ctgaaaaaaa    989

 aaaaa                                                                994




      <210> 133
      <211> 1367
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (33)..(632)

      <400> 133
 caccaccact gacctgggac agtgaatcga ca  atg ccg tct tct gtc tcg tgg      53
                                      Met Pro Ser Ser Val Ser Trp
                                        1               5

 ggc atc ctc ctg ctg gca ggc ctg tgc tgc ctg gtc cct gtc tcc ctg      101
 Gly Ile Leu Leu Leu Ala Gly Leu Cys Cys Leu Val Pro Val Ser Leu
          10                  15                  20

 gct gag gat ccc cag gga gat gct gcc cag aag aca gat aca tcc cac      149
 Ala Glu Asp Pro Gln Gly Asp Ala Ala Gln Lys Thr Asp Thr Ser His
      25                  30                  35

 cat gat cag gat cac cca acc ttc aac aag atc acc ccc aac ctg gct      197
 His Asp Gln Asp His Pro Thr Phe Asn Lys Ile Thr Pro Asn Leu Ala
  40                  45                  50                  55

 gag ttc gcc ttc agc cta tac cgc cag ctg gca cac cag tcc aac agc      245
 Glu Phe Ala Phe Ser Leu Tyr Arg Gln Leu Ala His Gln Ser Asn Ser
                  60                  65                  70

 acc aat atc ttc ttc tcc cca gtg agc atc gct aca gcc ttt gca atg      293
 Thr Asn Ile Phe Phe Ser Pro Val Ser Ile Ala Thr Ala Phe Ala Met
              75                  80                  85

 ctc tcc ctg ggg acc aag gct gac act cac gat gaa atc ctg gag ggc      341
 Leu Ser Leu Gly Thr Lys Ala Asp Thr His Asp Glu Ile Leu Glu Gly
          90                  95                 100

 ctg aat ttc aac ctc acg gag att ccg gag gct cag atc cat gaa ggc      389
 Leu Asn Phe Asn Leu Thr Glu Ile Pro Glu Ala Gln Ile His Glu Gly
     105                 110                 115

 ttc cag gaa ctc ctc cgt acc ctc aac cag cca gac agc cag ctc cag      437
 Phe Gln Glu Leu Leu Arg Thr Leu Asn Gln Pro Asp Ser Gln Leu Gln
 120                 125                 130                 135

 ctg acc acc ggc aat ggc ctg ttc ctc agc gag ggc ctg aag cta gtg      485
 Leu Thr Thr Gly Asn Gly Leu Phe Leu Ser Glu Gly Leu Lys Leu Val
                 140                 145                 150

 gat aag ttt ttg gag gat gtt aaa aag ttg tac cac tca gaa gcc ttc      533
 Asp Lys Phe Leu Glu Asp Val Lys Lys Leu Tyr His Ser Glu Ala Phe
             155                 160                 165

 act gtc aac ttc ggg gat cac cga aga ggc caa gaa aca gat caa cga      581
 Thr Val Asn Phe Gly Asp His Arg Arg Gly Gln Glu Thr Asp Gln Arg
         170                 175                 180

 tta cgt gga gaa ggg tac tca agg gaa aat tgt gga ttt ggt caa gga      629
 Leu Arg Gly Glu Gly Tyr Ser Arg Glu Asn Cys Gly Phe Gly Gln Gly
     185                 190                 195

 gct tgac agagacacag tttttgctct ggtgaattac atcttcttta aaggcaaatg      686
 Ala 
 200

 ggagagacct tttgaagtca aggacaccga ggacgaggac ttccacgtgg accaggtgac    746

 caccgtgaag gtccctatga tgaagcgttt aggcatgttt aacatccagc actgtaagaa    806

 gctgtccagc tgggtactgc taatgaaata cctgggcaat gccaccgcca tcttcttcct    866

 acctgatgag gggaaactac agcacctgga aaatgaactc acccacgata tcatcaccaa    926

 gttcctggaa aatgaagaca gaaggtctgc cagcttacat ttacccaaac tgtccattac    986

 tggaacctat gatctgaaga gcgtcctggg tcaactgggc atcactaagg tcttcagcaa   1046

 tggggctgac ctctccgggg tcacagagga ggcacccctg aagctctcca aggccgtgca   1106

 taaggctgtg ctgaccatcg acgagaaggg gactgaagct gctggggcca tgtttttaga   1166

 ggccatacca atgtctatcc ccccagaggt caagttcaac aaaccctttg tcttcttaat   1226

 gattgaacaa aataccaagt ctcccctctt catgggaaaa gtggtgaatc ccacccaaaa   1286

 ataactgcct ctcgctcctc aacccctccc ctccatccct ggccccctcc ctggatgaca   1346

 ttaaagaagg gttgagctgg a                                             1367




      <210> 134
      <211> 843
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (65)..(634)

      <400> 134
 agttgctcta ggtcgtaacc agcctttgaa aaaggagaaa ccaaaatgga aaagcgatta     60

 tcct atg aca gat gga caa cta cgc agc aag agg gat gaa ttt tgg gat     109
      Met Thr Asp Gly Gln Leu Arg Ser Lys Arg Asp Glu Phe Trp Asp
        1               5                  10                  15

 aca gca cca gct ttt gaa ggc cgg aaa gag att tgg gat gcc ttg aag      157
 Thr Ala Pro Ala Phe Glu Gly Arg Lys Glu Ile Trp Asp Ala Leu Lys
                  20                  25                  30

 gct gct gca cat gct ttt gag agc aat gat cat gaa ctg gca caa gca      205
 Ala Ala Ala His Ala Phe Glu Ser Asn Asp His Glu Leu Ala Gln Ala
              35                  40                  45

 atc att gat ggt gca aac ata aca tta cca cat ggt gca ctt aca gag      253
 Ile Ile Asp Gly Ala Asn Ile Thr Leu Pro His Gly Ala Leu Thr Glu
          50                  55                  60

 tgc tac gat gaa ctg ggg aac aga tat cag ctt cca gtg tat tgc ttg      301
 Cys Tyr Asp Glu Leu Gly Asn Arg Tyr Gln Leu Pro Val Tyr Cys Leu
      65                  70                  75

 gca ccg cca atc aac atg ata gag gaa aag agc gac ata gag act ctg      349
 Ala Pro Pro Ile Asn Met Ile Glu Glu Lys Ser Asp Ile Glu Thr Leu
  80                  85                  90                  95

 gat att cct gag cca cca ccc aat tct gga tat gaa tgt cag ctt cgt      397
 Asp Ile Pro Glu Pro Pro Pro Asn Ser Gly Tyr Glu Cys Gln Leu Arg
                 100                 105                 110

 ttg cgc ctt tcc aca ggc aaa gac ctc aag ctt gtg gtt cgc agc aca      445
 Leu Arg Leu Ser Thr Gly Lys Asp Leu Lys Leu Val Val Arg Ser Thr
             115                 120                 125

 gac aca gta ttc cac atg aag aga cgg ttg cat gca gca gag gga gtg      493
 Asp Thr Val Phe His Met Lys Arg Arg Leu His Ala Ala Glu Gly Val
         130                 135                 140

 gaa cca ggt agt cag cgg tgg ttt ttt tct ggc aga cct ctc act gac      541
 Glu Pro Gly Ser Gln Arg Trp Phe Phe Ser Gly Arg Pro Leu Thr Asp
     145                 150                 155

 aaa atg aag ttc gaa gag ctg aag atc cca aag gac tat gtt gta cag      589
 Lys Met Lys Phe Glu Glu Leu Lys Ile Pro Lys Asp Tyr Val Val Gln
 160                 165                 170                 175

 gtt ata gtg agc caa cct gtg cag aac cca aca cca gtg gag aac tga      637
 Val Ile Val Ser Gln Pro Val Gln Asn Pro Thr Pro Val Glu Asn 
                 180                 185                 190

 actgagccct gttggccagc tcccacatcc ctctgctcct ttttatggtt cttgttgtca    697

 tttcctactc tgcggcgtga aatctatttc actgctctaa attccctatg aatggattta    757

 gttctgagga attaccagtg aaaaattcca tctgtgatgg agaccaacaa aaataataaa    817

 acacaaagag ccagaaaaaa aaaaaa                                         843




      <210> 135
      <211> 1298
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (59)..(673)

      <400> 135
 cacgcgtccg gtccagtcgg tcttcctccg gcccgggccc tggcccagct agccggcc       58                                                                 
 atg gaa ggt aat ggc ccc gct gct gtc cac tac cag ccg gcc agc ccc      106
 Met Glu Gly Asn Gly Pro Ala Ala Val His Tyr Gln Pro Ala Ser Pro
   1               5                  10                  15

 ccg cgg gac gcc tgc gtc tac agc agc tgc tac tgt gaa gaa aat att      154
 Pro Arg Asp Ala Cys Val Tyr Ser Ser Cys Tyr Cys Glu Glu Asn Ile
              20                  25                  30

 tgg aag ctc tgt gaa tac atc aaa aac cat gac cag tat cct tta gaa      202
 Trp Lys Leu Cys Glu Tyr Ile Lys Asn His Asp Gln Tyr Pro Leu Glu
          35                  40                  45

 gaa tgt tat gct gtc ttc ata tct aat gag agg aag atg ata cct atc      250
 Glu Cys Tyr Ala Val Phe Ile Ser Asn Glu Arg Lys Met Ile Pro Ile
      50                  55                  60

 tgg aaa caa cag gcg aga cct gga gat gga cct gtg atc tgg gat tac      298
 Trp Lys Gln Gln Ala Arg Pro Gly Asp Gly Pro Val Ile Trp Asp Tyr
  65                  70                  75                  80

 cat gtt gtt ttg ctt cat gtt tca agt gga gga cag aac ttc att tat      346
 His Val Val Leu Leu His Val Ser Ser Gly Gly Gln Asn Phe Ile Tyr
                  85                  90                  95

 gat ctc gat act gtc ttg cca ttt ccc tgc ctc ttt gac act tat gta      394
 Asp Leu Asp Thr Val Leu Pro Phe Pro Cys Leu Phe Asp Thr Tyr Val
             100                 105                 110

 gaa gat gcc ttt aag tct gat gat gac att cac cca cag ttt agg agg      442
 Glu Asp Ala Phe Lys Ser Asp Asp Asp Ile His Pro Gln Phe Arg Arg
         115                 120                 125

 aaa ttt aga gtg atc cgt gca gat tca tat ttg aag aac ttt gct tct      490
 Lys Phe Arg Val Ile Arg Ala Asp Ser Tyr Leu Lys Asn Phe Ala Ser
     130                 135                 140

 gac cga tct cac atg aaa gac tcc agt ggg aat tgg aga gag cct ccg      538
 Asp Arg Ser His Met Lys Asp Ser Ser Gly Asn Trp Arg Glu Pro Pro
 145                 150                 155                 160

 ccg cca tat ccc tgc att gag act gga gat tcc aaa atg aac ctg aac      586
 Pro Pro Tyr Pro Cys Ile Glu Thr Gly Asp Ser Lys Met Asn Leu Asn
                 165                 170                 175

 gat ttc atc agt atg gat ccc aag gta gga tgg ggc gcc gtc tac aca      634
 Asp Phe Ile Ser Met Asp Pro Lys Val Gly Trp Gly Ala Val Tyr Thr
             180                 185                 190

 cta tcc gaa ttt aca cat cgg ttt ggc agt aaa aac tgc tgaacttggt       683
 Leu Ser Glu Phe Thr His Arg Phe Gly Ser Lys Asn Cys 
         195                 200                 205

 ctcaagatgt ggaactgtgg agaaattcta ggacatgaac aagctatcct ttcatcgagg    743

 acagcaaaca ttatggtaca gttggcttgg aattatgtct ttctctttta atttgattga    803

 gtggaaatct gagtgaatac aaatataaat gaacaacata aaaacttttg ttttgacatg    863

 tcaaattgaa acttgataaa gtgcgtactt gctaagatat tcctgtggct catgcgttac    923

 aacacgagga cttaagccag taatcgtttt tgttcagata gaggtgtgga ggtagagcca    983

 gcccctcatg tctgttttgg atgttttgtg tctctccagc tacattgtaa gttccttgag   1043

 ggcagggcca tggcccattg ctctgtgaat ctcaaatgcc cataaaaggt gcccataaaa   1103

 tgttttcttg aacatttgaa tgtgctgttg tctggaaagg ggtaatattg tgagctgaat   1163

 cagcaataag tattagtctt tttggactat ggtattgtta aaaagactgc agccctctca   1223

 gacttgagcg ttaattggct tatttattta tggctttaaa taaaatcgat ttaacgttaa   1283

 aaaaaaaaaa aaaaa                                                    1298




      <210> 136
      <211> 690
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (376)..(576)

      <400> 136
 ctcttctcat accctgtgct aacaactttt aacaaaaaat ttgcatcact tttaagaatc     60

 aagaaaaatt tctgaaggtc atatgggaca gaaaaaaaaa ccaagggaaa aatcacgcca    120

 cttgggaaaa aaagattcga aatctgcctt tttatagatt tgtaattaat aaggtccagg    180

 ctttctaagc aacttaaatg ttttgtttcg aaacaaagta cttgtctgga tgtaggagga    240

 aagggagtga tgtcactgcc attatgatgc cccttgaata taagacccta cttgctatct    300

 cccctgcacc agccaggagc cacccatcct ccagcacact gagcagcaag ctggacacac    360

 ggcacactga tccaa atg ggt aag ggg atg gtg gcg atg ctc att ctg ggt     411
                  Met Gly Lys Gly Met Val Ala Met Leu Ile Leu Gly
                    1               5                  10

 ctg cta ctt ctg gcg ctg ctc cta ccc gtg cag gtt tct tca ttt gtt      459
 Leu Leu Leu Leu Ala Leu Leu Leu Pro Val Gln Val Ser Ser Phe Val
          15                  20                  25

 cct tta acc agt atg ccg gaa gct act gca gcc gaa acc aca aag ccc      507
 Pro Leu Thr Ser Met Pro Glu Ala Thr Ala Ala Glu Thr Thr Lys Pro
      30                  35                  40

 tcc aac agt gcc cta cag cct aca gcc ggt ctc ctt gtg gtc ttg ctt      555
 Ser Asn Ser Ala Leu Gln Pro Thr Ala Gly Leu Leu Val Val Leu Leu
  45                  50                  55                  60

 gcc ctt cta cat ctc tac cat ta agaggcaggt caagaaacag ctacagttct      608
 Ala Leu Leu His Leu Tyr His 
                  65

 ccaacccata cactaaaacc gaatccaaat ggtgcctaga agttcaatgt ggcaatcccg    668

 aaaaaaaaga ccaaaaaaag ac                                             690




      <210> 137
      <211> 1089
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (126)..(836)

      <400> 137
 taagcttgcg ccgatctttt ttttcttttt tttttttttg gaaccgcggt tgtttaaaag     60

 cctgagggaa cctggagggg ggctcccact ctctaccttc tttcctccga gtttgtgact    120

 ccgag    atg gac aaa gtg tgt gct gtt ttt gga ggc tcc cga ggc att     167
          Met Asp Lys Val Cys Ala Val Phe Gly Gly Ser Arg Gly Ile
            1               5                  10

 ggc aga gct gtg gcc cag tta atg gcc cgg aaa ggc tac cga ctg gcg      215
 Gly Arg Ala Val Ala Gln Leu Met Ala Arg Lys Gly Tyr Arg Leu Ala
  15                  20                  25                  30

 gtc att gcc aga aac ctg gaa ggg gcc aaa gcc gcc gcc ggt gac ctc      263
 Val Ile Ala Arg Asn Leu Glu Gly Ala Lys Ala Ala Ala Gly Asp Leu
                  35                  40                  45

 ggc gga gat cat ttg gca ttt agc tgt gat gtt gct aaa gaa cat gat      311
 Gly Gly Asp His Leu Ala Phe Ser Cys Asp Val Ala Lys Glu His Asp
              50                  55                  60

 gtt caa aat aca ttt gaa gag atg gag aaa cat tta ggt cga gta aat      359
 Val Gln Asn Thr Phe Glu Glu Met Glu Lys His Leu Gly Arg Val Asn
          65                  70                  75

 ttc ttg gta aat gca gct ggt att aac agg gat ggt ctt tta gta aga      407
 Phe Leu Val Asn Ala Ala Gly Ile Asn Arg Asp Gly Leu Leu Val Arg
      80                  85                  90

 aca aaa act gaa gat atg gta tct cag ctt cat act aac ctc ttg ggt      455
 Thr Lys Thr Glu Asp Met Val Ser Gln Leu His Thr Asn Leu Leu Gly
  95                 100                 105                 110

 tcc atg ctg acc tgt aaa gct gcc atg agg act atg att caa caa cag      503
 Ser Met Leu Thr Cys Lys Ala Ala Met Arg Thr Met Ile Gln Gln Gln
                 115                 120                 125

 gga ggg tct att gtt aat gta gga agc att gtt ggc tta aaa ggc aac      551
 Gly Gly Ser Ile Val Asn Val Gly Ser Ile Val Gly Leu Lys Gly Asn
             130                 135                 140

 tct ggc cag tcc gtt tac agt gcc agt aaa gga gga tta gtt gga ttt      599
 Ser Gly Gln Ser Val Tyr Ser Ala Ser Lys Gly Gly Leu Val Gly Phe
         145                 150                 155

 tca cgt gct ctt gct aaa gag gta gca aga aag aaa att aga gtg aat      647
 Ser Arg Ala Leu Ala Lys Glu Val Ala Arg Lys Lys Ile Arg Val Asn
     160                 165                 170

 gta gtt gca cca gga ttt gta cac aca gat atg acg aaa gac ttg aaa      695
 Val Val Ala Pro Gly Phe Val His Thr Asp Met Thr Lys Asp Leu Lys
 175                 180                 185                 190

 gaa gaa cat tta aag aaa aat att cct ctt ggg agg ttt gga gaa act      743
 Glu Glu His Leu Lys Lys Asn Ile Pro Leu Gly Arg Phe Gly Glu Thr
                 195                 200                 205

 att gag gtg gca cat gcg gtt gtg ttt ctt tta gaa tca ccg tat att      791
 Ile Glu Val Ala His Ala Val Val Phe Leu Leu Glu Ser Pro Tyr Ile
             210                 215                 220

 aca ggg cat gtt ctg gta gtg gat ggg gga tta caa ctc att ttg taa      839
 Thr Gly His Val Leu Val Val Asp Gly Gly Leu Gln Leu Ile Leu 
         225                 230                 235

 tttgcagatt attcagttat aggggtgatt agcatcaagg gcacactttg gctactgatt    899

 agacaattat acctacatgg gtaacatgtg ctaatcaaac ctgctgatgc tacaaatgtt    959

 aatttctgtc tttataaaaa tatgtctcaa aagaacaatg tgtgacaaat tgtggttttt   1019

 tttttttggg tcaaagcaac atcagggtgg tttggttaaa aaagccttta tgaaatacaa   1079

 ttcacatact                                                          1089




      <210> 138
      <211> 1024
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (111)..(698)

      <400> 138
 ccagagaagt cttggtggaa acgtatgaag agagtgtgcc tgtgtccagt taccagcagg     60

 caggaattcc cgtggacttg aaaaggaaga ttgcacggct ggggatcaac   atg ctc     116
                                                          Met Leu
                                                            1

 ctg aag atg ata ttt gtg gat aac ttt gtc cat gca gac ctt cac cct      164
 Leu Lys Met Ile Phe Val Asp Asn Phe Val His Ala Asp Leu His Pro
           5                  10                  15

 gga aac atc ctg gtt cag ggt gcc aac ggc ctg tcc tcg agt cag gag      212
 Gly Asn Ile Leu Val Gln Gly Ala Asn Gly Leu Ser Ser Ser Gln Glu
      20                  25                  30

 gcg cag ctg cag cag gcg gac atc tgt gac act ctg gtg gtg gcc gtg      260
 Ala Gln Leu Gln Gln Ala Asp Ile Cys Asp Thr Leu Val Val Ala Val
  35                  40                  45                  50

 cca tct tcc ctc tgc ccg ctg cga ctg gtg ctg ctg gat gct ggc att      308
 Pro Ser Ser Leu Cys Pro Leu Arg Leu Val Leu Leu Asp Ala Gly Ile
                  55                  60                  65

 gtg gcg gag ctg cag gcc cct gac ctg agg aat ttc cgg gca gtt ttc      356
 Val Ala Glu Leu Gln Ala Pro Asp Leu Arg Asn Phe Arg Ala Val Phe
              70                  75                  80

 atg gct gtg gtg atg ggg cag ggc cag aga gtg gct gag ctg atc ctg      404
 Met Ala Val Val Met Gly Gln Gly Gln Arg Val Ala Glu Leu Ile Leu
          85                  90                  95

 cat cat gcc cgg gcc agc gag tgc agg gac gtg gag ggg ttc aaa acc      452
 His His Ala Arg Ala Ser Glu Cys Arg Asp Val Glu Gly Phe Lys Thr
     100                 105                 110

 gag atg gcc atg ctg gtg acc cag gcc agg aag aac acc atc acc ctg      500
 Glu Met Ala Met Leu Val Thr Gln Ala Arg Lys Asn Thr Ile Thr Leu
 115                 120                 125                 130

 gag aag ctt cat gtg tcc agc ctt ctc tct agt gtc ttt aag ttg ctg      548
 Glu Lys Leu His Val Ser Ser Leu Leu Ser Ser Val Phe Lys Leu Leu
                 135                 140                 145

 atg act cac aag gta aag ctt gag agc aac ttt gcc tcc att gtg ttt      596
 Met Thr His Lys Val Lys Leu Glu Ser Asn Phe Ala Ser Ile Val Phe
             150                 155                 160

 gcc atc atg gtg ttg gag ggg ctt ggc cgc tca ctg gac ccc aaa ctg      644
 Ala Ile Met Val Leu Glu Gly Leu Gly Arg Ser Leu Asp Pro Lys Leu
         165                 170                 175

 gac atc ctg gag gca gcg agg ccc ttc ctc ctc acg ggc cca gtg tgc      692
 Asp Ile Leu Glu Ala Ala Arg Pro Phe Leu Leu Thr Gly Pro Val Cys
     180                 185                 190

 ccc ccg tgatggggca gtggcctctg tgggcccttg tcaagagctg gaggccactc       748
 Pro Pro 
 195

 ccaagagcct ctcctatggc agctgggacg ttttaaaatt gggacaccaa tttcaaatgt    808

 aaccctccag tggtggaagg cacaccatgg cttcctctgc ttggtttgag ggtctgttca    868

 aaagctttgg gccaattagg gagtaaaagg agggaagggg cctatccatt ccattgtgga    928

 agctgggcca ggtgccaggg acactctcct tcagggaaaa tgttatgtgg aggaggacga    988

 ataaatttat tttgttttaa aaaaaaaaaa aaaagg                             1024




      <210> 139
      <211> 913
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (184)..(912)

      <400> 139
 aagctgatgt gttattcctt ctctgcatcg aaggatcagg aagtttgtgc tctctgcgtg     60

 gctaagtttt tcacctacta ggacgggggt ggggtgggga gaacaggtgt ccttctaaaa    120

 tacagcacaa gctacagcct gcgtccagcc ataacccagg agtaacatca gaaacaggtg    180

 aga  atg acc act tta act cac cgg gcc cgt cgc act gaa ata agc aag     228
      Met Thr Thr Leu Thr His Arg Ala Arg Arg Thr Glu Ile Ser Lys
        1               5                  10                  15

 aac tct gaa aag aag atg gaa agt gag gaa gac agt aat tgg gag aaa      276
 Asn Ser Glu Lys Lys Met Glu Ser Glu Glu Asp Ser Asn Trp Glu Lys
                  20                  25                  30

 agt cca gac aat gaa gat tct gga gac tct aag gat atc cgc ctt act      324
 Ser Pro Asp Asn Glu Asp Ser Gly Asp Ser Lys Asp Ile Arg Leu Thr
              35                  40                  45

 ctt atg gaa gaa gta ttg ctt ctg gga cta aaa gat aaa gag ggg tac      372
 Leu Met Glu Glu Val Leu Leu Leu Gly Leu Lys Asp Lys Glu Gly Tyr
          50                  55                  60

 aca tct ttc tgg aat gac tgc ata tca tca ggc ctg cga ggg ggc atc      420
 Thr Ser Phe Trp Asn Asp Cys Ile Ser Ser Gly Leu Arg Gly Gly Ile
      65                  70                  75

 ctg ata gag ctg gcc atg cgg ggt cga atc tat ctg gaa ccc ccg acc      468
 Leu Ile Glu Leu Ala Met Arg Gly Arg Ile Tyr Leu Glu Pro Pro Thr
  80                  85                  90                  95

 atg cgt aag aag cga cta cta gac aga aag gta ctg cta aag tca gac      516
 Met Arg Lys Lys Arg Leu Leu Asp Arg Lys Val Leu Leu Lys Ser Asp
                 100                 105                 110

 agc cca aca ggt gat gtt tta ctg gat gaa act ctg aaa cac atc aaa      564
 Ser Pro Thr Gly Asp Val Leu Leu Asp Glu Thr Leu Lys His Ile Lys
             115                 120                 125

 gca act gaa ccc aca gaa act gtc caa aca tgg ata gag cta ctc act      612
 Ala Thr Glu Pro Thr Glu Thr Val Gln Thr Trp Ile Glu Leu Leu Thr
         130                 135                 140

 ggt gag acc tgg aac ccc ttc aaa tta cag tac cag ctg aga aat gta      660
 Gly Glu Thr Trp Asn Pro Phe Lys Leu Gln Tyr Gln Leu Arg Asn Val
     145                 150                 155

 cga gag cgc atc gca aag aac cta gta gag aaa ggt att cta acc act      708
 Arg Glu Arg Ile Ala Lys Asn Leu Val Glu Lys Gly Ile Leu Thr Thr
 160                 165                 170                 175

 gag aag cag aat ttc ctg cta ttt gac atg act act cat cca gtg acc      756
 Glu Lys Gln Asn Phe Leu Leu Phe Asp Met Thr Thr His Pro Val Thr
                 180                 185                 190

 aat aca aca gag aaa cag cga cta gtg aaa aaa ctt caa gat agt gta      804
 Asn Thr Thr Glu Lys Gln Arg Leu Val Lys Lys Leu Gln Asp Ser Val
             195                 200                 205

 cta gag cgg tgg gta aat gac cct cag cgt atg gac aag cga aca cta      852
 Leu Glu Arg Trp Val Asn Asp Pro Gln Arg Met Asp Lys Arg Thr Leu
         210                 215                 220

 gca ctc ctg gtg cta gcc cac tcc tct gat gtg cta gag aat gtc ttc      900
 Ala Leu Leu Val Leu Ala His Ser Ser Asp Val Leu Glu Asn Val Phe
     225                 230                 235

 tcc tct ctg aca g                                                    913
 Ser Ser Leu Thr 
 240





      <210> 140
      <211> 1644
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (249)..(1532)

      <220>
      <221> misc_feature
      <222> (1)...(1644)
      <223> n = a,t,c or g

      <400> 140
 atcctcgcgg gtccacgatt tcgtcccgcg gtcccacggc gcctggttgc ccccagcccc     60

 ctccctcctc ccaccttcat tgtgtcccac ccttcctagc tttgtgcccg gggtgctgag    120

 cccttccccg tcagccgggc cgcgggagga gggagccgtc accgaggagc tgccgctcgc    180

 tgccccgggc aggggcacag gcttcatcca gtgaatacta gagggattgt acagttgcaa    240

 ccaaggca atg tct tac tac ctc agc tca gaa aac cac ctg gac cca ggg     290
          Met Ser Tyr Tyr Leu Ser Ser Glu Asn His Leu Asp Pro Gly
            1               5                  10

 ccc atc tac atg cga gaa aat ggg cag ctg cac atg gtc aat ctg gct      338
 Pro Ile Tyr Met Arg Glu Asn Gly Gln Leu His Met Val Asn Leu Ala
  15                  20                  25                  30

 ctg gat ggt gtc agg agt agc ctg cag aag cca agg cct ttc aga ctg      386
 Leu Asp Gly Val Arg Ser Ser Leu Gln Lys Pro Arg Pro Phe Arg Leu
                  35                  40                  45

 ttc ccc aaa ggc ttt tct gtg gag ctt tgc atg aac agg gaa gac gac      434
 Phe Pro Lys Gly Phe Ser Val Glu Leu Cys Met Asn Arg Glu Asp Asp
              50                  55                  60

 act gca cgg aaa gag aag act gat cat ttc atc ttc aca tac acc cga      482
 Thr Ala Arg Lys Glu Lys Thr Asp His Phe Ile Phe Thr Tyr Thr Arg
          65                  70                  75

 gag ggg aat ctt cgg tac tcc gcc aaa tcc ctc ttc agc ctt gtc ctg      530
 Glu Gly Asn Leu Arg Tyr Ser Ala Lys Ser Leu Phe Ser Leu Val Leu
      80                  85                  90

 ggt ttc atc tcc gac aat gtg gat cac att gat tcc ctt att ggc ttt      578
 Gly Phe Ile Ser Asp Asn Val Asp His Ile Asp Ser Leu Ile Gly Phe
  95                 100                 105                 110

 cct gag cag att gct gaa aag ctg ttc tct gct gct gaa gcc aga cag      626
 Pro Glu Gln Ile Ala Glu Lys Leu Phe Ser Ala Ala Glu Ala Arg Gln
                 115                 120                 125

 aaa ttc act gag cca ggt gca ggg ctg agg gct tta cag aaa ttc act      674
 Lys Phe Thr Glu Pro Gly Ala Gly Leu Arg Ala Leu Gln Lys Phe Thr
             130                 135                 140

 gag gcc tat gga agt ttg gtg ctt tgc tcc ctg tgt ttg cga aac agg      722
 Glu Ala Tyr Gly Ser Leu Val Leu Cys Ser Leu Cys Leu Arg Asn Arg
         145                 150                 155

 tat ctc gtg att tca gaa aag ctt gag gag att aag tct ttc cgg gag      770
 Tyr Leu Val Ile Ser Glu Lys Leu Glu Glu Ile Lys Ser Phe Arg Glu
     160                 165                 170

 ctg acc tgc ctg gat ctt tcc tgt tgc aag ctt gga gat gag cat gaa      818
 Leu Thr Cys Leu Asp Leu Ser Cys Cys Lys Leu Gly Asp Glu His Glu
 175                 180                 185                 190

 ctt cta gaa cat ctc acc aat gaa gcc ctg tct agt gta act cag ctc      866
 Leu Leu Glu His Leu Thr Asn Glu Ala Leu Ser Ser Val Thr Gln Leu
                 195                 200                 205

 cac ctg aag gat aat tgt tta tct gat gct ggg gtg cgg aag atg aca      914
 His Leu Lys Asp Asn Cys Leu Ser Asp Ala Gly Val Arg Lys Met Thr
             210                 215                 220

 gca cca gtt cga gtg atg aaa aga ggc ctt gag aat cta aca tta tta      962
 Ala Pro Val Arg Val Met Lys Arg Gly Leu Glu Asn Leu Thr Leu Leu
         225                 230                 235

 gac tta tca tgt aac cct gag atc aca gat gca ggc att gga tac ctc     1010
 Asp Leu Ser Cys Asn Pro Glu Ile Thr Asp Ala Gly Ile Gly Tyr Leu
     240                 245                 250

 ttt ttt ttt agg aaa cta aac tgc tta gat atc tct ggg aca ggg ctc     1058
 Phe Phe Phe Arg Lys Leu Asn Cys Leu Asp Ile Ser Gly Thr Gly Leu
 255                 260                 265                 270

 aag gac atc aaa acc gtc aag cac aag ctc cag acc cac ata ggc ctt     1106
 Lys Asp Ile Lys Thr Val Lys His Lys Leu Gln Thr His Ile Gly Leu
                 275                 280                 285

 gtt cac tcc aaa gtg cct ttg aag gaa ttt gat cat agt aac tgc aag     1154
 Val His Ser Lys Val Pro Leu Lys Glu Phe Asp His Ser Asn Cys Lys
             290                 295                 300

 aca gag ggc tgg gct gac cag atc gtt ctg cag tgg gag cgt gtg act     1202
 Thr Glu Gly Trp Ala Asp Gln Ile Val Leu Gln Trp Glu Arg Val Thr
         305                 310                 315

 gcg gaa gct gtg aag cca cgg gag acc tcg gag cct aga gca gca gct     1250
 Ala Glu Ala Val Lys Pro Arg Glu Thr Ser Glu Pro Arg Ala Ala Ala
     320                 325                 330

 cag cgc ttc tat ggg aag cgg tct cga gca gaa gcc cca ctg aag tgt     1298
 Gln Arg Phe Tyr Gly Lys Arg Ser Arg Ala Glu Ala Pro Leu Lys Cys
 335                 340                 345                 350

 ccc ctg gca gac acc cac atg aac tct tcc gag aaa ctc cag ttc tat     1346
 Pro Leu Ala Asp Thr His Met Asn Ser Ser Glu Lys Leu Gln Phe Tyr
                 355                 360                 365

 aaa gag aaa gcc cca gat tgc cat ggg cca gtg ttg aaa cac gaa gct     1394
 Lys Glu Lys Ala Pro Asp Cys His Gly Pro Val Leu Lys His Glu Ala
             370                 375                 380

 atc tca agc cag gag tca aag aag agc aag aag aga cct ttt gag gag     1442
 Ile Ser Ser Gln Glu Ser Lys Lys Ser Lys Lys Arg Pro Phe Glu Glu
         385                 390                 395

 tca gag aca gaa cag aat aac tct tca caa cct tca aag cag aaa tat     1490
 Ser Glu Thr Glu Gln Asn Asn Ser Ser Gln Pro Ser Lys Gln Lys Tyr
     400                 405                 410

 gta tgt ctt gct gtg gaa gac tgg gac ttg tta aat tcc tat tgattag     1539
 Val Cys Leu Ala Val Glu Asp Trp Asp Leu Leu Asn Ser Tyr 
 415                 420                 425

 tagatacaag ttgacctttc tctggccccc agctctagtg tttgagtaaa ggagactgag   1599

 gatgatttac ttttggttga atntacctat ggcattagca tagta                   1644




      <210> 141
      <211> 390
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (20)..(343)

      <400> 141
 gcgcgtcgac gtcaccgcc atg gct gcc ccg tgt ttg ctg cgg caa gga cga      52
                      Met Ala Ala Pro Cys Leu Leu Arg Gln Gly Arg
                        1               5                  10

 gcc ggg gcg ctg aag act atg ctc cag gaa gcc cag gtg ttt cga gga      100
 Ala Gly Ala Leu Lys Thr Met Leu Gln Glu Ala Gln Val Phe Arg Gly
              15                  20                  25

 ctt gct tct acg gtt tct ttg tct gcg gaa tca ggg aag agt gaa aag      148
 Leu Ala Ser Thr Val Ser Leu Ser Ala Glu Ser Gly Lys Ser Glu Lys
          30                  35                  40

 ggt cag cca cag aat tcc aag aag caa agt cca cca aaa aag cca gcc      196
 Gly Gln Pro Gln Asn Ser Lys Lys Gln Ser Pro Pro Lys Lys Pro Ala
      45                  50                  55

 cca gtg cct gct gag ccg ttt gac aac act acc tac aag aac ctg cag      244
 Pro Val Pro Ala Glu Pro Phe Asp Asn Thr Thr Tyr Lys Asn Leu Gln
  60                  65                  70                  75

 cat cat gac tac agc acg tac acc ttc tta gac ctc aac ctc gaa ctc      292
 His His Asp Tyr Ser Thr Tyr Thr Phe Leu Asp Leu Asn Leu Glu Leu
                  80                  85                  90

 tca aaa ttc agg atg cct cag ccc tcc tca ggc cgg gag tca cct cga      340
 Ser Lys Phe Arg Met Pro Gln Pro Ser Ser Gly Arg Glu Ser Pro Arg
              95                 100                 105

 cac tgagggccct cggtgtgaag atgaaccttc caccgtcttc actgcat              390
 His 






      <210> 142
      <211> 453
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (20)..(406)

      <400> 142
 gcgcgtcgac gtcaccgcc atg gct gcc ccg tgt ttg ctg cgg caa gga cga      52
                      Met Ala Ala Pro Cys Leu Leu Arg Gln Gly Arg
                        1               5                  10

 gcc ggg gcg ctg aag act atg ctc cag gaa gcc cag gtg ttt cga gga      100
 Ala Gly Ala Leu Lys Thr Met Leu Gln Glu Ala Gln Val Phe Arg Gly
              15                  20                  25

 ctt gct tct acg gtt tct ttg tct gcg gaa tca ggg aag agt gaa aag      148
 Leu Ala Ser Thr Val Ser Leu Ser Ala Glu Ser Gly Lys Ser Glu Lys
          30                  35                  40

 ggt cag cca cag aat tcc aag aag caa agt cca cca aaa agt gtc cct      196
 Gly Gln Pro Gln Asn Ser Lys Lys Gln Ser Pro Pro Lys Ser Val Pro
      45                  50                  55

 aca cca cac cga aga tac tca cct tgt gga gat tgg aag gat gcc agc      244
 Thr Pro His Arg Arg Tyr Ser Pro Cys Gly Asp Trp Lys Asp Ala Ser
  60                  65                  70                  75

 tct tta aag cca gcc cca gtg cct gct gag ccg ttt gac aac act acc      292
 Ser Leu Lys Pro Ala Pro Val Pro Ala Glu Pro Phe Asp Asn Thr Thr
                  80                  85                  90

 tac aag aac ctg cag cat cat gac tac agc acg tac acc ttc tta gac      340
 Tyr Lys Asn Leu Gln His His Asp Tyr Ser Thr Tyr Thr Phe Leu Asp
              95                 100                 105

 ctc aac ctc gaa ctc tca aaa ttc agg atg cct cag ccc tcc tca ggc      388
 Leu Asn Leu Glu Leu Ser Lys Phe Arg Met Pro Gln Pro Ser Ser Gly
         110                 115                 120

 cgg gag tca cct cga cac tgaggg ccctcggtgt gaagatgaac cttccaccgt      442
 Arg Glu Ser Pro Arg His 
     125

 cttcactgca t                                                         453




      <210> 143
      <211> 470
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (137)..(250)

      <400> 143
 ggggggggga atatggactt tatggctcaa gtgcaaactc tgatgatgtc cagtcagtat     60

 gaggctgcat tgaagaaggc gaacctgaaa ggctacggcc gataattggt cgcccgagaa    120

 gttacggaga gtaaaa    atg aaa gtt cgt gct tcc gtc aag aaa tta tgc     169
                      Met Lys Val Arg Ala Ser Val Lys Lys Leu Cys
                        1               5                  10

 cgt aac tgc aaa atc gtt aag cgt gat ggt gtc atc cgt gtg att tgc      217
 Arg Asn Cys Lys Ile Val Lys Arg Asp Gly Val Ile Arg Val Ile Cys
              15                  20                  25

 agt gcc gag ccg aag cat aaa cag cgc caa ggc tgattttt tcgcatattt      268
 Ser Ala Glu Pro Lys His Lys Gln Arg Gln Gly 
          30                  35

 ttcttgcaaa gttgggttga gctggctaga ttagccagcc aatcttttgt atgtctgtgc    328

 gtttccattt gagtatcctg aaaacgggct tttcagcatg gaacgtacat attaaacagt    388

 aggagtaaat agggtcccgc aaagcaggcc ccagcattcc tgttctccgg gtacggacat    448

 agaatccgta atgatggtca ca                                             470




      <210> 144
      <211> 637
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (379)..(573)

      <400> 144
 atctgcaccg cgtcagtgct cgccgggcta tatccagcaa aggcagtacc cgcgaaacag     60

 cgagtgatgt cgtagccact ttgggagtgc agtgatgatg aagctgatta atcgcagtaa    120

 gcaatcacct attggtcgcc gcgcttgcga tgttgcgctg gcagctcact tgcaaacata    180

 tggcgactat gggcgaagca agatgaaaga gacttatacg gtgaaggttg aaggcgtgaa    240

 agtctgggtg gaggtggtga accgaaaggc gagctacgtg gccacagcga tgaccggcat    300

 gcgccgtctc cgctccctgc ccgggcaggt tggttgaaaa agattttgaa tggcccgaac    360

 gggcaactgg agagagct  atg gat gat att ttg gta acg tca gac ctg acc     411
                      Met Asp Asp Ile Leu Val Thr Ser Asp Leu Thr
                        1               5                  10

 agt cgc tac aaa att tca cgc aaa acc ctt tgg tca tgg caa agt gca      459
 Ser Arg Tyr Lys Ile Ser Arg Lys Thr Leu Trp Ser Trp Gln Ser Ala
              15                  20                  25

 gac aca atg cct cgg ggc ttc gta tgc ccg ttc cca ccc cct gac tgg      507
 Asp Thr Met Pro Arg Gly Phe Val Cys Pro Phe Pro Pro Pro Asp Trp
          30                  35                  40

 ccc ggc aac cct aac cgc tgg cgc tct gag tca atc aaa gag tgg gag      555
 Pro Gly Asn Pro Asn Arg Trp Arg Ser Glu Ser Ile Lys Glu Trp Glu
      45                  50                  55

 gat aaa aag aag ata aat taactg aagggctctc cgatgatctc ttcaagatgg      609
 Asp Lys Lys Lys Ile Asn 
  60                  65

 ctctgccaaa cgcggagcca gtgtttct                                       637




      <210> 145
      <211> 1961
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (108)..(650)

      <400> 145
 cgtctggcag gccgcgtggc gcccgcgccg gccttcctgc aggggactcc accggagcct     60

 tgccaattcc gtttgtttcc ctgttgtcgc ccgcttcacc ctggatc  atg ttc aag     116
                                                      Met Phe Lys
                                                        1

 aag ttt gat gaa aag gaa agt gtg tcc aac tgc atc cag ttg aaa acg      164
 Lys Phe Asp Glu Lys Glu Ser Val Ser Asn Cys Ile Gln Leu Lys Thr
       5                  10                  15

 tca gtt att aag ggc att aag agc caa ctg gta gag caa ttt cca ggt      212
 Ser Val Ile Lys Gly Ile Lys Ser Gln Leu Val Glu Gln Phe Pro Gly
  20                  25                  30                  35

 att gaa cca tgg ctt aat caa atc atg cct aag aaa gat cct gtc aaa      260
 Ile Glu Pro Trp Leu Asn Gln Ile Met Pro Lys Lys Asp Pro Val Lys
                  40                  45                  50

 ata gtc cga tgc cac gaa cat aca gaa atc ctt acc gta agt ggg gaa      308
 Ile Val Arg Cys His Glu His Thr Glu Ile Leu Thr Val Ser Gly Glu
              55                  60                  65

 tta ttg ttt ttt aga caa aga aag ggg cct ttt tgt cca act cta agg      356
 Leu Leu Phe Phe Arg Gln Arg Lys Gly Pro Phe Cys Pro Thr Leu Arg
          70                  75                  80

 ttg ctt cac aaa tac cct ttt atc ctg cca cac cag cag gtt gat aaa      404
 Leu Leu His Lys Tyr Pro Phe Ile Leu Pro His Gln Gln Val Asp Lys
      85                  90                  95

 gga gct atc aaa ttt gta ctc agt ggc gca aat att atg tgt cca ggt      452
 Gly Ala Ile Lys Phe Val Leu Ser Gly Ala Asn Ile Met Cys Pro Gly
 100                 105                 110                 115

 tta act tct cct gga gct aag ctg tac cct gct gca gta gat acg att      500
 Leu Thr Ser Pro Gly Ala Lys Leu Tyr Pro Ala Ala Val Asp Thr Ile
                 120                 125                 130

 gta gca gtc aca gcg gaa gga aaa cag cat gct ctg tgt gtt ggg gtc      548
 Val Ala Val Thr Ala Glu Gly Lys Gln His Ala Leu Cys Val Gly Val
             135                 140                 145

 atg aag atg tct gca gaa gat att gag aaa gtc aac aaa gga att ggc      596
 Met Lys Met Ser Ala Glu Asp Ile Glu Lys Val Asn Lys Gly Ile Gly
         150                 155                 160

 att gaa aat atc cat tat tta aat gat ggg ctg tgg cac atg aag aca      644
 Ile Glu Asn Ile His Tyr Leu Asn Asp Gly Leu Trp His Met Lys Thr
     165                 170                 175

 tat aaa tgagcctcag aaggaatgca tttggggggc taaatgtgga tattgattgt       700
 Tyr Lys 
 180

 gtcgtatgtg tgtttgtgtc tgtgtgtgac agcgtgaata caatgcctct gtggttatgc    760

 taaataagtt taacagatac tttatagaaa acaaatcagg gtgctcttac cacagatgaa    820

 aaaacaaatt aggggacaag cagcaagcag tctgctaaca ctctggaatg tgaaaggagt    880

 gtctggactc tgtgactccc ggcaaactcc acagcctcta gttgtcttct taggaagctt    940

 ggaagcaatt gagaatggtc taacatcaag atgtctacca cagggccccc cacaaaagca   1000

 gcctcgggga ctccggcctt tccttgagac ctgcatctct tcccttcttc atcgcctgct   1060

 agtgaactga ggctgccgct aaccttcttc atcctttggt ggcaaagtag aaagattcca   1120

 gaattaactc gacctttcta aagacctggg ctcagaggca gctggcactg actgagcacc   1180

 cactatgtgc caggcactgt gctgaatgca ttagatcatc aattatgaat ttgacaccaa   1240

 ggacctggtg tgcctgggcc tgagcagcat cgttggcgtc tggtacctgc tgaggaagca   1300

 ctggattgcc aacaaccttt ttggcctggc cttctccctt aatggagtag agctcctgca   1360

 cctcaacaat gtcagcactg gctgcatcct gctgggcgga ctcttcatct acgatgtctt   1420

 ctgggtattt ggcaccaatg tgatggtgac agtggccaag tccttcgagg caccaataaa   1480

 atgtgacaaa actaaggcag tggtgtttcc ccaggatctg ctggagaaag gcctcgaagc   1540

 aaacaacttt gccatgctgg gacttggaga tgtcgtcatt ccagggatct tcattgcctt   1600

 gctgctgcgc tttgacatca gcttgaagaa gaatacccac acctacttct acaccagctt   1660

 tgcagcctac atcttcggcc tgggccttac catcttcatc atgcacatct tcaagcatgc   1720

 tcagcctgcc ctcctatacc tggtccccgc ctgcatcggt tttcctgtcc tggtggcgct   1780

 ggccaaggga gaagtgacag agatgttcag ctacgagtcc tcggcggaaa tcctgcctca   1840

 taccccgagg ctcacccact tccccacagt ctcgggctcc ccagccagcc tggccgactc   1900

 catgcagcag aagctagctg gccctcgccg ccggcgcccg cagaatccca gcgccatgta   1960

 a                                                                   1961




      <210> 146
      <211> 2699
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (292)..(1149)

      <400> 146
 acctagtggg tcttggggac cttcgaaatc gccgccgctc tcacaatggc ttgggtccag     60

 actgcgccac agcctctcgg gagacgtggg ccctcggaac ctttttagtg ccggactccg    120

 ggccgcaggc agtcccgcgg cagcaggatc acagaacctc tggatggact cttcctggga    180

 agctttgcta ctttgcagca gctggaccat gttcctcatt aacatctgtc tgtccgctta    240

 gtcatcacat catttcactg tgctcttgag gctagtgcgc ctctaggcaa g atg tcc     297
                                                          Met Ser
                                                            1

 ctg ccc atc ggg ata tac cgc cgg gca gtc agc tat gat gat acc ctc      345
 Leu Pro Ile Gly Ile Tyr Arg Arg Ala Val Ser Tyr Asp Asp Thr Leu
           5                  10                  15

 gag gac cct gcg ccc atg act cct cct cca tcg gac atg ggc agc gtc      393
 Glu Asp Pro Ala Pro Met Thr Pro Pro Pro Ser Asp Met Gly Ser Val
      20                  25                  30

 cct tgg aag cca gtg att cca gag cgc aag tat cag cac ctc gcc aag      441
 Pro Trp Lys Pro Val Ile Pro Glu Arg Lys Tyr Gln His Leu Ala Lys
  35                  40                  45                  50

 gtg gag gaa gga gag gcc agt cta ccc tcc cct gcc atg acc ctg tca      489
 Val Glu Glu Gly Glu Ala Ser Leu Pro Ser Pro Ala Met Thr Leu Ser
                  55                  60                  65

 tca gcc att gac agt gtg gac aag gtc cca gtg gtg aag gct aaa gct      537
 Ser Ala Ile Asp Ser Val Asp Lys Val Pro Val Val Lys Ala Lys Ala
              70                  75                  80

 acc cat gtc atc atg aat tct ctg atc aca aaa cag acc cag gaa agc      585
 Thr His Val Ile Met Asn Ser Leu Ile Thr Lys Gln Thr Gln Glu Ser
          85                  90                  95

 att cag cat ttt gag cga cag gca ggg ctg aga gat gct ggc tac aca      633
 Ile Gln His Phe Glu Arg Gln Ala Gly Leu Arg Asp Ala Gly Tyr Thr
     100                 105                 110

 ccc cac aag ggc ctc acc acc gag gag acc aag tac ctt cga gtg gcc      681
 Pro His Lys Gly Leu Thr Thr Glu Glu Thr Lys Tyr Leu Arg Val Ala
 115                 120                 125                 130

 gaa gca ctc cac aaa cta aag tta cag agt gga gag gta aca aaa gaa      729
 Glu Ala Leu His Lys Leu Lys Leu Gln Ser Gly Glu Val Thr Lys Glu
                 135                 140                 145

 gag agg cag cct gca tca gcc cag tcc acc cca agc acc act ccg cac      777
 Glu Arg Gln Pro Ala Ser Ala Gln Ser Thr Pro Ser Thr Thr Pro His
             150                 155                 160

 tct tca cct aag cag agg ccc agg ggc tgg ttc act tct ggt tct tcc      825
 Ser Ser Pro Lys Gln Arg Pro Arg Gly Trp Phe Thr Ser Gly Ser Ser
         165                 170                 175

 aca gcc tta cct ggc cca aat cct agc acc atg gac tct gga agt ggg      873
 Thr Ala Leu Pro Gly Pro Asn Pro Ser Thr Met Asp Ser Gly Ser Gly
     180                 185                 190

 gat aag gac aga aac ttg tca gat aag tgg agc ctc ttt gga ccg aga      921
 Asp Lys Asp Arg Asn Leu Ser Asp Lys Trp Ser Leu Phe Gly Pro Arg
 195                 200                 205                 210

 tcc ctt cag aag tac gat tct gga agt ttt gcc acc cag gcc tac cga      969
 Ser Leu Gln Lys Tyr Asp Ser Gly Ser Phe Ala Thr Gln Ala Tyr Arg
                 215                 220                 225

 gga gcc cag aag ccc tct cca ttg gaa ctg ata cgt gcc cag gcc aac     1017
 Gly Ala Gln Lys Pro Ser Pro Leu Glu Leu Ile Arg Ala Gln Ala Asn
             230                 235                 240

 cga atg gct gaa gat cca gca gcc ttg aag ccc ccc aag atg gac atc     1065
 Arg Met Ala Glu Asp Pro Ala Ala Leu Lys Pro Pro Lys Met Asp Ile
         245                 250                 255

 cca gtg atg gaa gga aag aaa cag cca cca cgg gcc cat aac ctc aaa     1113
 Pro Val Met Glu Gly Lys Lys Gln Pro Pro Arg Ala His Asn Leu Lys
     260                 265                 270

 ccc cgt gac ctg aat gtg ctc aca ccc act ggc ttc taga gccctctttc     1163
 Pro Arg Asp Leu Asn Val Leu Thr Pro Thr Gly Phe 
 275                 280                 285

 cagggattct ggtaaaggtg gtttcttgca tcccactccc cttttacctt ggctttgaca   1223

 taggaaaggt atatttaaaa acttaatcag ctgggcgtgg tggctcacgc ctgtaatccc   1283

 agcactttgg gaggccaagg taggtggata cctgaggtca ggagttcaag accagcctgg   1343

 ccaacatggt gaaaccccgt ctctactaaa aatacaaaaa ttagctgggc gtggtggtgg   1403

 gcgcctgtag tcccagctac ttgggaggct gaggcaggag aatcgcctga acccaggaag   1463

 cagatgttgt accgagctga gatcatgcca ttacactcca gcctgggcga cagaacgaga   1523

 cgccatcaat aaataaataa ataaagtaaa gtaaaaaacc tattaaattg aggctagagc   1583

 tggagatgta attggttttt gagaaacatt agtataaagc ttgcccttgt tgtgtggaag   1643

 aagccatttt gtactgcttt aaagttagac taatattctc agcacgggtg tatggggacc   1703

 tcattaccta tttttttcat catttaccct aggtaagaac tttgatcact gcttactagg   1763

 taaagaatgt ttgtactgtt ccaaaaccca ggcttcttta ttcctttacc actatccatg   1823

 tgagcattga caaatcatgg cttagaggtg ctcactgact cgctaagacg actttggccc   1883

 tgttgatgac tggtgctgtg ctccagcctt atcagttagg ggacccaagg tttgtttggg   1943

 acctgggtac aggtaaaagc cagacttggc agggacccct ctttctaggc tgaaccttga   2003

 gtccccctgc tttttggcag acctaatgga tcactgtctt gcagctagtt cttcatgtgg   2063

 ggcctcttag gccagtgccg gaggaggcat gctcctcttt ctatgccaca gaacaaacac   2123

 tactctagca gagcctttct tgcactttaa agtgagatta atttagctgt aatttggtta   2183

 aaaacttcct aagagagaaa attaagtcta ctgatttggt ataggtaaat ggacattaaa   2243

 cttttttaaa gtaaaggaga tggtagatac cgttagatta tagtcttgag gttcatgtga   2303

 agccagtggt gttaacttac tttgatttcc ttgttcaggt cagggcctgg aacgcctgtg   2363

 cggggaggtc actcaattca aaattttctg tatgaaagca tttttcacca aaatgagcct   2423

 catcccttta tgcaacacat aaccttactg agggagggaa atacagaagc caccttttta   2483

 tttctcttca ctgtgtacaa gttcacttgt tgtcttgaac actgtctcaa atacctgctt   2543

 tttgttttgg atagtacctt gtctgtataa gaagctggcc tttccataga gaggccctgg   2603

 agtctaaaat tatgagaaca attaatttat ttgtgtcttc tattatgatc tcgttttgac   2663

 aataaaaatc cttactactt tctcaaaaaa aaaaaa                             2699




      <210> 147
      <211> 7037
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (9)..(4919)

      <400> 147
 ccacctcc atg tgt acg gca gaa cag ttc cgc tgt cac tca ggc cgc tgt      50
          Met Cys Thr Ala Glu Gln Phe Arg Cys His Ser Gly Arg Cys
            1               5                  10

 gtc cgc ctg tcc tgg cgc tgt gat ggg gag gac gac tgt gca gac aac       98
 Val Arg Leu Ser Trp Arg Cys Asp Gly Glu Asp Asp Cys Ala Asp Asn
  15                  20                  25                  30

 agc gat gaa gag aac tgt gag aat aca gga agc ccc caa tgt gcc ttg      146
 Ser Asp Glu Glu Asn Cys Glu Asn Thr Gly Ser Pro Gln Cys Ala Leu
                  35                  40                  45

 gac cag ttc ctg tgt tgg aat ggg cgc tgc att ggg cag agg aag ctg      194
 Asp Gln Phe Leu Cys Trp Asn Gly Arg Cys Ile Gly Gln Arg Lys Leu
              50                  55                  60

 tgc aac ggg gtc aac gac tgt ggt gac aac agc gac gaa agc cca cag      242
 Cys Asn Gly Val Asn Asp Cys Gly Asp Asn Ser Asp Glu Ser Pro Gln
          65                  70                  75

 cag aat tgc cgg ccc cgg acg ggt gag gag aac tgc aat gtt aac aac      290
 Gln Asn Cys Arg Pro Arg Thr Gly Glu Glu Asn Cys Asn Val Asn Asn
      80                  85                  90

 ggt ggc tgt gcc cag aag tgc cag atg gtg cgg ggg gca gtg cag tgt      338
 Gly Gly Cys Ala Gln Lys Cys Gln Met Val Arg Gly Ala Val Gln Cys
  95                 100                 105                 110

 acc tgc cac aca ggc tac cgg ctc aca gag gat ggg cac acg tgc caa      386
 Thr Cys His Thr Gly Tyr Arg Leu Thr Glu Asp Gly His Thr Cys Gln
                 115                 120                 125

 gat gtg aat gaa tgt gcc gag gag ggg tat tgc agc cag ggc tgc acc      434
 Asp Val Asn Glu Cys Ala Glu Glu Gly Tyr Cys Ser Gln Gly Cys Thr
             130                 135                 140

 aac agc gaa ggg gct ttc caa tgc tgg tgt gaa aca ggc tat gaa cta      482
 Asn Ser Glu Gly Ala Phe Gln Cys Trp Cys Glu Thr Gly Tyr Glu Leu
         145                 150                 155

 cgg ccc gac cgg cgc agc tgc aag gct ctg ggg cca gag cct gtg ctg      530
 Arg Pro Asp Arg Arg Ser Cys Lys Ala Leu Gly Pro Glu Pro Val Leu
     160                 165                 170

 ctg ttc gcc aat cgc atc gac atc cgg cag gtg ctg cca cac cgc tct      578
 Leu Phe Ala Asn Arg Ile Asp Ile Arg Gln Val Leu Pro His Arg Ser
 175                 180                 185                 190

 gag tac aca ctg ctg ctt aac aac ctg gag aat gcc att gcc ctt gat      626
 Glu Tyr Thr Leu Leu Leu Asn Asn Leu Glu Asn Ala Ile Ala Leu Asp
                 195                 200                 205

 ttc cac cac cgc cgc gag ctt gtc ttc tgg tca gat gtc acc ctg gac      674
 Phe His His Arg Arg Glu Leu Val Phe Trp Ser Asp Val Thr Leu Asp
             210                 215                 220

 cgg atc ctc cgt gcc aac ctc aac ggc agc aac gtg gag gag gtt gtg      722
 Arg Ile Leu Arg Ala Asn Leu Asn Gly Ser Asn Val Glu Glu Val Val
         225                 230                 235

 tct act ggg ctg gag agc cca ggg ggc ctg gct gtg gat tgg gtc cat      770
 Ser Thr Gly Leu Glu Ser Pro Gly Gly Leu Ala Val Asp Trp Val His
     240                 245                 250

 gac aaa ctc tac tgg acc gac tca ggc acc tcg agg att gag gtg gcc      818
 Asp Lys Leu Tyr Trp Thr Asp Ser Gly Thr Ser Arg Ile Glu Val Ala
 255                 260                 265                 270

 aat ctg gac ggg gcc cac cgg aag gtg ttg ctg tgg cag aac ctg gag      866
 Asn Leu Asp Gly Ala His Arg Lys Val Leu Leu Trp Gln Asn Leu Glu
                 275                 280                 285

 aag ccc cgg gcc att gcc ttg cat ccc atg gag ggt acc att tac tgg      914
 Lys Pro Arg Ala Ile Ala Leu His Pro Met Glu Gly Thr Ile Tyr Trp
             290                 295                 300

 aca gac tgg ggc aac acc ccc cgt att gag gcc tcc agc atg gat ggc      962
 Thr Asp Trp Gly Asn Thr Pro Arg Ile Glu Ala Ser Ser Met Asp Gly
         305                 310                 315

 tct gga cgc cgc atc att gcc gat acc cat ctc ttc tgg ccc aat ggc     1010
 Ser Gly Arg Arg Ile Ile Ala Asp Thr His Leu Phe Trp Pro Asn Gly
     320                 325                 330

 ctc acc atc gac tat gcc ggg cgc cgt atg tac tgg gtg gat gct aag     1058
 Leu Thr Ile Asp Tyr Ala Gly Arg Arg Met Tyr Trp Val Asp Ala Lys
 335                 340                 345                 350

 cac cat gtc atc gag agg gcc aat ctg gat ggg agt cac cgt aag gct     1106
 His His Val Ile Glu Arg Ala Asn Leu Asp Gly Ser His Arg Lys Ala
                 355                 360                 365

 gtc att agc cag ggc ctc ccg cat ccc ttc gcc atc aca gtg ttt gaa     1154
 Val Ile Ser Gln Gly Leu Pro His Pro Phe Ala Ile Thr Val Phe Glu
             370                 375                 380

 gac agc ctg tac tgg aca gac tgg cac acc aag agc atc aat agc gct     1202
 Asp Ser Leu Tyr Trp Thr Asp Trp His Thr Lys Ser Ile Asn Ser Ala
         385                 390                 395

 aac aaa ttt acg ggg aag aac cag gaa atc att cgc aac aaa ctc cac     1250
 Asn Lys Phe Thr Gly Lys Asn Gln Glu Ile Ile Arg Asn Lys Leu His
     400                 405                 410

 ttc cct atg gac atc cac acc ttg cac ccc cag cgc caa cct gca ggg     1298
 Phe Pro Met Asp Ile His Thr Leu His Pro Gln Arg Gln Pro Ala Gly
 415                 420                 425                 430

 aaa aac cgc tgt ggg gac aac aac gga ggc tgc acg cac ctg tgt ctg     1346
 Lys Asn Arg Cys Gly Asp Asn Asn Gly Gly Cys Thr His Leu Cys Leu
                 435                 440                 445

 ccc agt ggc cag aac tac acc tgt gcc tgc ccc act ggc ttc cgc aag     1394
 Pro Ser Gly Gln Asn Tyr Thr Cys Ala Cys Pro Thr Gly Phe Arg Lys
             450                 455                 460

 atc agc agc cac gcc tgt gcc cag agt ctt gac aag ttc ctg ctt ttt     1442
 Ile Ser Ser His Ala Cys Ala Gln Ser Leu Asp Lys Phe Leu Leu Phe
         465                 470                 475

 gcc cga agg atg gac atc cgt cga atc agc ttt gac aca gag gac ctg     1490
 Ala Arg Arg Met Asp Ile Arg Arg Ile Ser Phe Asp Thr Glu Asp Leu
     480                 485                 490

 tct gat gat gtc atc cca ctg gct gac gtg cgc agt gct gtg gcc ctt     1538
 Ser Asp Asp Val Ile Pro Leu Ala Asp Val Arg Ser Ala Val Ala Leu
 495                 500                 505                 510

 gac tgg gac tcc cgg gat gac cac gtg tac tgg aca gat gtc agc act     1586
 Asp Trp Asp Ser Arg Asp Asp His Val Tyr Trp Thr Asp Val Ser Thr
                 515                 520                 525

 gat acc atc agc agg gcc aag tgg gat gga aca gga cag gag gtg gta     1634
 Asp Thr Ile Ser Arg Ala Lys Trp Asp Gly Thr Gly Gln Glu Val Val
             530                 535                 540

 gtg gat acc agt ttg gag agc cca gct ggc ctg gcc att gat tgg gtc     1682
 Val Asp Thr Ser Leu Glu Ser Pro Ala Gly Leu Ala Ile Asp Trp Val
         545                 550                 555

 acc aac aaa ctg tac tgg aca gat gca ggt aca gac cgg att gaa gta     1730
 Thr Asn Lys Leu Tyr Trp Thr Asp Ala Gly Thr Asp Arg Ile Glu Val
     560                 565                 570

 gcc aac aca gat ggc agc atg aga aca gta ctc atc tgg gag aac ctt     1778
 Ala Asn Thr Asp Gly Ser Met Arg Thr Val Leu Ile Trp Glu Asn Leu
 575                 580                 585                 590

 gat cgt cct cgg gac atc gtg gtg gaa ccc atg ggc ggg tac atg tat     1826
 Asp Arg Pro Arg Asp Ile Val Val Glu Pro Met Gly Gly Tyr Met Tyr
                 595                 600                 605

 tgg act gac tgg ggt gcg agc ccc aag att gaa cga gct ggc atg gat     1874
 Trp Thr Asp Trp Gly Ala Ser Pro Lys Ile Glu Arg Ala Gly Met Asp
             610                 615                 620

 gcc tca ggc cgc caa gtc att atc tct tct aat ctg acc tgg cct aat     1922
 Ala Ser Gly Arg Gln Val Ile Ile Ser Ser Asn Leu Thr Trp Pro Asn
         625                 630                 635

 ggg tta gct att gat tat ggg tcc cag cgt cta tac tgg gct gac gcc     1970
 Gly Leu Ala Ile Asp Tyr Gly Ser Gln Arg Leu Tyr Trp Ala Asp Ala
     640                 645                 650

 ggc atg aag aca att gaa ttt gct gga ctg gat ggc agt aag agg aag     2018
 Gly Met Lys Thr Ile Glu Phe Ala Gly Leu Asp Gly Ser Lys Arg Lys
 655                 660                 665                 670

 gtg ctg att gga agc cag ctc ccc cac cca ttt ggg ctg acc ctc tat     2066
 Val Leu Ile Gly Ser Gln Leu Pro His Pro Phe Gly Leu Thr Leu Tyr
                 675                 680                 685

 gga gag cgc atc tat tgg act gac tgg cag acc aag agc ata cag agc     2114
 Gly Glu Arg Ile Tyr Trp Thr Asp Trp Gln Thr Lys Ser Ile Gln Ser
             690                 695                 700

 gct gac cgg ctg aca ggg ctg gac cgg gag act ctg cag gag aac ctg     2162
 Ala Asp Arg Leu Thr Gly Leu Asp Arg Glu Thr Leu Gln Glu Asn Leu
         705                 710                 715

 gaa aac cta atg gac atc cat gtc ttc cac cgc cgc cgg ccc cca gtg     2210
 Glu Asn Leu Met Asp Ile His Val Phe His Arg Arg Arg Pro Pro Val
     720                 725                 730

 tct aca cca tgt gct atg gag aat ggc ggc tgt agc cac ctg tgt ctt     2258
 Ser Thr Pro Cys Ala Met Glu Asn Gly Gly Cys Ser His Leu Cys Leu
 735                 740                 745                 750

 agg tcc cca aat cca agc gga ttc agc tgt acc tgc ccc aca ggc atc     2306
 Arg Ser Pro Asn Pro Ser Gly Phe Ser Cys Thr Cys Pro Thr Gly Ile
                 755                 760                 765

 aac ctg ctg tct gat ggc aag acc tgc tca cca ggc atg aac agt ttc     2354
 Asn Leu Leu Ser Asp Gly Lys Thr Cys Ser Pro Gly Met Asn Ser Phe
             770                 775                 780

 ctc atc ttc gcc agg agg ata gac att cgc atg gtc tcc ctg gac atc     2402
 Leu Ile Phe Ala Arg Arg Ile Asp Ile Arg Met Val Ser Leu Asp Ile
         785                 790                 795

 cct tat ttt gct gat gtg gtg gta cca atc aac att acc atg aag aac     2450
 Pro Tyr Phe Ala Asp Val Val Val Pro Ile Asn Ile Thr Met Lys Asn
     800                 805                 810

 acc att gcc gtt gga gta gac ccc cag gaa gga aag gtg tac tgg tct     2498
 Thr Ile Ala Val Gly Val Asp Pro Gln Glu Gly Lys Val Tyr Trp Ser
 815                 820                 825                 830

 gac agc aca ctg cac agg atc agt cgt gcc aat ctg gat ggc tca cag     2546
 Asp Ser Thr Leu His Arg Ile Ser Arg Ala Asn Leu Asp Gly Ser Gln
                 835                 840                 845

 cat gag gac atc atc acc aca ggg cta cag acc aca gat ggg ctc gcg     2594
 His Glu Asp Ile Ile Thr Thr Gly Leu Gln Thr Thr Asp Gly Leu Ala
             850                 855                 860

 gtt gat gcc att ggc cgg aaa gta tac tgg aca gac acg gga aca aac     2642
 Val Asp Ala Ile Gly Arg Lys Val Tyr Trp Thr Asp Thr Gly Thr Asn
         865                 870                 875

 cgg att gaa gtg ggc aac ctg gac ggg tcc atg cgg aaa gtg ttg gtg     2690
 Arg Ile Glu Val Gly Asn Leu Asp Gly Ser Met Arg Lys Val Leu Val
     880                 885                 890

 tgg cag aac ctt gac agt ccc cgg gcc atc gta ctg tac cat gag atg     2738
 Trp Gln Asn Leu Asp Ser Pro Arg Ala Ile Val Leu Tyr His Glu Met
 895                 900                 905                 910

 ggg ttt atg tac tgg aca gac tgg ggg gag aat gcc aag tta gag cgg     2786
 Gly Phe Met Tyr Trp Thr Asp Trp Gly Glu Asn Ala Lys Leu Glu Arg
                 915                 920                 925

 tcc gga atg gat ggc tca gac cgc gcg gtg ctc atc aac aac aac cta     2834
 Ser Gly Met Asp Gly Ser Asp Arg Ala Val Leu Ile Asn Asn Asn Leu
             930                 935                 940

 gga tgg ccc aat gga ctg act gtg gac aag gcc agc tcc caa ctg cta     2882
 Gly Trp Pro Asn Gly Leu Thr Val Asp Lys Ala Ser Ser Gln Leu Leu
         945                 950                 955

 tgg gcc gat gcc cac acc gag cga att gag gct gct gac ctg aat ggt     2930
 Trp Ala Asp Ala His Thr Glu Arg Ile Glu Ala Ala Asp Leu Asn Gly
     960                 965                 970

 gcc aat cgg cat aca ttg gtg tca ccg gtg cag cac cca tat ggc ctc     2978
 Ala Asn Arg His Thr Leu Val Ser Pro Val Gln His Pro Tyr Gly Leu
 975                 980                 985                 990

 acc ctg ctc gac tcc tat atc tac tgg act gac tgg cag act cgg agc     3026
 Thr Leu Leu Asp Ser Tyr Ile Tyr Trp Thr Asp Trp Gln Thr Arg Ser
                 995                1000                1005

 atc cac cgt gct gac aag ggt act ggc agc aat gtc atc ctc gtg agg     3074
 Ile His Arg Ala Asp Lys Gly Thr Gly Ser Asn Val Ile Leu Val Arg
            1010                1015                1020

 tcc aac ctg cca ggc ctc atg gac atg cag gct gtg gac cgg gca cag     3122
 Ser Asn Leu Pro Gly Leu Met Asp Met Gln Ala Val Asp Arg Ala Gln
        1025                1030                1035

 cca cta ggt ttt aac aag tgc ggc tcg aga aat ggc ggc tgc tcc cac     3170
 Pro Leu Gly Phe Asn Lys Cys Gly Ser Arg Asn Gly Gly Cys Ser His
    1040                1045                1050

 ctc tgc ttg cct cgg cct tct ggc ttc tcc tgt gcc tgc ccc act ggc     3218
 Leu Cys Leu Pro Arg Pro Ser Gly Phe Ser Cys Ala Cys Pro Thr Gly
1055                1060                1065                1070

 atc cag ctg aag gga gat ggg aag acc tgt gat ccc tct cct gag acc     3266
 Ile Gln Leu Lys Gly Asp Gly Lys Thr Cys Asp Pro Ser Pro Glu Thr
                1075                1080                1085

 tac ctg ctc ttc tcc agc cgt ggc tcc atc cgg cgt atc tca ctg gac     3314
 Tyr Leu Leu Phe Ser Ser Arg Gly Ser Ile Arg Arg Ile Ser Leu Asp
            1090                1095                1100

 acc agt gac cac acc gat gtg cat gtc cct gtt cct gag ctc aac aat     3362
 Thr Ser Asp His Thr Asp Val His Val Pro Val Pro Glu Leu Asn Asn
        1105                1110                1115

 gtc atc tcc ctg gac tat gac agc gtg gat gga aag gtc tat tac aca     3410
 Val Ile Ser Leu Asp Tyr Asp Ser Val Asp Gly Lys Val Tyr Tyr Thr
    1120                1125                1130

 gat gtg ttc ctg gat gtt atc agg cga gca gac ctg aac ggc agc aac     3458
 Asp Val Phe Leu Asp Val Ile Arg Arg Ala Asp Leu Asn Gly Ser Asn
1135                1140                1145                1150

 atg gag aca gtg atc ggg cga ggg ctg aag acc act gac ggg ctg gca     3506
 Met Glu Thr Val Ile Gly Arg Gly Leu Lys Thr Thr Asp Gly Leu Ala
                1155                1160                1165

 gtg gac tgg gtg gcc agg aac ctg tac tgg aca gac aca ggt cga aat     3554
 Val Asp Trp Val Ala Arg Asn Leu Tyr Trp Thr Asp Thr Gly Arg Asn
            1170                1175                1180

 acc att gag gcg tcc agg ctg gat ggt tcc tgc cgc aaa gta ctg atc     3602
 Thr Ile Glu Ala Ser Arg Leu Asp Gly Ser Cys Arg Lys Val Leu Ile
        1185                1190                1195

 aac aat agc ctg gat gag ccc cgg gcc att gct gtt ttc ccc agg aag     3650
 Asn Asn Ser Leu Asp Glu Pro Arg Ala Ile Ala Val Phe Pro Arg Lys
    1200                1205                1210

 ggg tac ctc ttc tgg aca gac tgg ggc cac att gcc aag atc gaa cgg     3698
 Gly Tyr Leu Phe Trp Thr Asp Trp Gly His Ile Ala Lys Ile Glu Arg
1215                1220                1225                1230

 gca aac ttg gat ggt tct gag cgg aag gtc ctc atc aac aca gac ctg     3746
 Ala Asn Leu Asp Gly Ser Glu Arg Lys Val Leu Ile Asn Thr Asp Leu
                1235                1240                1245

 ggt tgg ccc aat ggc ctt acc ctg gac tat gat acc cgc agg atc tac     3794
 Gly Trp Pro Asn Gly Leu Thr Leu Asp Tyr Asp Thr Arg Arg Ile Tyr
            1250                1255                1260

 tgg gtg gat gcg cat ctg gac cgg atc gag agt gct gac ctc aat ggg     3842
 Trp Val Asp Ala His Leu Asp Arg Ile Glu Ser Ala Asp Leu Asn Gly
        1265                1270                1275

 aaa ctg cgg cag gtc ttg gtc ggc cat gtg tcc cac ccc ttt gcc ctc     3890
 Lys Leu Arg Gln Val Leu Val Gly His Val Ser His Pro Phe Ala Leu
    1280                1285                1290

 aca cag caa gac agg tgg atc tac tgg aca gac tgg cag acc aag tca     3938
 Thr Gln Gln Asp Arg Trp Ile Tyr Trp Thr Asp Trp Gln Thr Lys Ser
1295                1300                1305                1310

 atc cag cgt gtt gac aaa tac tca ggc cgg aac aag gag aca gtg ctg     3986
 Ile Gln Arg Val Asp Lys Tyr Ser Gly Arg Asn Lys Glu Thr Val Leu
                1315                1320                1325

 gca aat gtg gaa gga ctc atg gat atc atc gtg gtt tcc cct cag cgg     4034
 Ala Asn Val Glu Gly Leu Met Asp Ile Ile Val Val Ser Pro Gln Arg
            1330                1335                1340

 cag aca ggg acc aat gcc tgt ggt gtg aac aat ggt ggc tgc acc cac     4082
 Gln Thr Gly Thr Asn Ala Cys Gly Val Asn Asn Gly Gly Cys Thr His
        1345                1350                1355

 ctc tgc ttt gcc aga gcc tcg gac ttc gta tgt gcc tgt cct gac gaa     4130
 Leu Cys Phe Ala Arg Ala Ser Asp Phe Val Cys Ala Cys Pro Asp Glu
    1360                1365                1370

 cct gat agc cgg ccc tgc tcc ctt gtg cct ggc ctg gta cca cca gct     4178
 Pro Asp Ser Arg Pro Cys Ser Leu Val Pro Gly Leu Val Pro Pro Ala
1375                1380                1385                1390

 cct agg gct act ggc atg agt gaa aag agc cca gtg cta ccc aac aca     4226
 Pro Arg Ala Thr Gly Met Ser Glu Lys Ser Pro Val Leu Pro Asn Thr
                1395                1400                1405

 cca cct acc acc ttg tat tct tca acc acc cgg acc cgc acg tct ctg     4274
 Pro Pro Thr Thr Leu Tyr Ser Ser Thr Thr Arg Thr Arg Thr Ser Leu
            1410                1415                1420

 gag gag gtg gaa gga aga tgc tct gaa agg gat gcc agg ctg ggc ctc     4322
 Glu Glu Val Glu Gly Arg Cys Ser Glu Arg Asp Ala Arg Leu Gly Leu
        1425                1430                1435

 tgt gca cgt tcc aat gac gct gtt cct gct gct cca ggg gaa gga ctt     4370
 Cys Ala Arg Ser Asn Asp Ala Val Pro Ala Ala Pro Gly Glu Gly Leu
    1440                1445                1450

 cat atc agc tac gcc att ggt gga ctc ctc agt att ctg ctg att ttg     4418
 His Ile Ser Tyr Ala Ile Gly Gly Leu Leu Ser Ile Leu Leu Ile Leu
1455                1460                1465                1470

 gtg gtg att gca gct ttg atg ctg tac aga cac aaa aaa tcc aag ttc     4466
 Val Val Ile Ala Ala Leu Met Leu Tyr Arg His Lys Lys Ser Lys Phe
                1475                1480                1485

 act gat cct gga atg ggg aac ctc acc tac agc aac ccc tcc tac cga     4514
 Thr Asp Pro Gly Met Gly Asn Leu Thr Tyr Ser Asn Pro Ser Tyr Arg
            1490                1495                1500

 aca tcc aca cag gaa gtg aag att gaa gca atc ccc aaa cca gcc atg     4562
 Thr Ser Thr Gln Glu Val Lys Ile Glu Ala Ile Pro Lys Pro Ala Met
        1505                1510                1515

 tac aac cag ctg tgc tat aag aaa gag gga ggg cct gac cat aac tac     4610
 Tyr Asn Gln Leu Cys Tyr Lys Lys Glu Gly Gly Pro Asp His Asn Tyr
    1520                1525                1530

 acc aag gag aag atc aag atc gta gag gga atc tgc ctc ctg tct ggg     4658
 Thr Lys Glu Lys Ile Lys Ile Val Glu Gly Ile Cys Leu Leu Ser Gly
1535                1540                1545                1550

 gat gat gct gag tgg gat gac ctc aag caa ctg cga agc tca cgg ggg     4706
 Asp Asp Ala Glu Trp Asp Asp Leu Lys Gln Leu Arg Ser Ser Arg Gly
                1555                1560                1565

 ggc ctc ctc cgg gat cat gta tgc atg aag aca gac acg gtg tcc atc     4754
 Gly Leu Leu Arg Asp His Val Cys Met Lys Thr Asp Thr Val Ser Ile
            1570                1575                1580

 cag gcc agc tct ggc tcc ctg gat gac aca gag atg gag cag ctg tta     4802
 Gln Ala Ser Ser Gly Ser Leu Asp Asp Thr Glu Met Glu Gln Leu Leu
        1585                1590                1595

 cag gaa gag cag tct gag tgt agc agc gtc cat act gca gcc act cca     4850
 Gln Glu Glu Gln Ser Glu Cys Ser Ser Val His Thr Ala Ala Thr Pro
    1600                1605                1610

 gaa aga cga ggc tct ctg cca gac acg ggc tgg aaa cat gaa cgc aag     4898
 Glu Arg Arg Gly Ser Leu Pro Asp Thr Gly Trp Lys His Glu Arg Lys
1615                1620                1625                1630

 ctc tcc tca gag agc cag gtc ta aatgcccaca ttctcttccc tgcctgcctg     4951
 Leu Ser Ser Glu Ser Gln Val 
                1635

 ttccttctcc tttatggacg tctagtcctt gtgctcgctt acaccgcagg ccccgcttct   5011

 gtgtgcttgt cctcctcctc ctcccacccc ataactgttc ctaagccttc accggagctg   5071

 tttaccacgt gagtccataa ctacctgtgc acaagaaatg atggcacatc acgagaattt   5131

 agacctggat tttaccatga acctcacatc ttgtactcca tcctgggccc cctgaaactg   5191

 cttattcgtg attcctcacc agcgtagagc tccacctccc ctttccccag taccctcagt   5251

 gcctgcttct cagtgctgat gcagctgatg acccaggact gcgctctgcc ccatcacagc   5311

 cagcatgact gcttctctga gagaacttgc ccatcagggg ctgggacatg ggggtgtggg   5371

 taaagacagg gatgaaggat agaggctgag agaagaagga agaatcagcc cagcaggtat   5431

 gggcatctgg gaaacctcca gcctcaagtg tgttggtaac atgaaaaagc tctggggggt   5491

 agttggatct gggtgtctgg tccattgctg gcagtggaca ttattcttgc cctaagagac   5551

 actgcctttt cagcagcaga tactggtgag atgggggtgg ctcaggctgt tcttcctcct   5611

 cctagaatgt ctggagctgt ttctacattc agataactgg gtcccctatc acaaggctac   5671

 tggctaatag gaattccctc ctggtgccac cactggccag tacctttcct aagtctttgc   5731

 tcaaattaac caggttgtga gccagtggct tgagtgaatg ttaggccttg ggggctgagt   5791

 ctctgaaaag tctaagaagc tctgcctaga ccaaatatgg tatacctcct gacccctctc   5851

 tccctcatgt cctgggattc tggggaagag acctagaaac aagctttcaa agaaaaacca   5911

 gaagttgtca taaatggtca gaaagaacga tcaggttgga gacttgggaa acccagggcc   5971

 taaagagaag tatccatgag ggtcaaactt cctgttgaac ttcctatgtt ctttctcaag   6031

 tgctcaggga tctaagttag tggacagcaa gcctgtggct acggggtggt gatgttcctc   6091

 ttccagctgt cccctcagct aaggggctta gtttccatgt gggatgccat cacttggttc   6151

 atgctcattc acacaaaggg cacgtgtctc agcctggtat cagggaaatt gagacttatt   6211

 tttgccctaa aacgtctccc tagctgttct tcgtggggtt tttttgtttg tttttttgcc   6271

 taatttgctt tttctgacca agccttgtgg caccagcaat ctccaaagtc ctgtggtggg   6331

 agggctgaat aaataaaaat acaaagaggt gggtaaggag taggaaggta gagagcacca   6391

 ctgatgaggc cctcctagcc catggcagac ccagacctct tctcccccag gaattagaag   6451

 tggcaggaga gaacaacagg ggctgggaat ggaggggaga atttctaggg gaagtttcct   6511

 gagttgaaac ttctcctgtg gttactggta ttgagaaatc agctaccaaa gtgaaaaagg   6571

 acaagatcaa ttcttttcta gtcagttcta agactgctag agagagatac caggccctta   6631

 gccttgctct cagtagcgtc agccccagtt ctgagcctcc ccacattaca cttaacaagc   6691

 agtaaaggag tgagcacttt gggtccttag actcatgtct ggggaggaag agcaagtaga   6751

 aaagtggcat tttcttgatt ggaaaggggg aaggatctta ttgcacttgg gctgttcaga   6811

 atgtagaaag gacatatttg aggaagtatc tatttgagca ctgatttact ctgtaaaaag   6871

 caaaatctct ctgtcctaaa ctaatggaag cgattctccc atgctcatgt gtaatggttt   6931

 taacgttact cactggagag attggacttt ctggagttat ttaaccacta tgttcagtat   6991

 tttaggactt tatgataatt taatataaat ttagcttttc ttaatc                  7037




      <210> 148
      <211> 6779
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (14)..(1963)

      <400> 148
 tcgtggcgag aag   atg gcg act tcg aac aat ccg cgg aaa ttc agc gag      49
                  Met Ala Thr Ser Asn Asn Pro Arg Lys Phe Ser Glu
                    1               5                  10

 aag atc gcg ctg cac aat cag aag cag gcg gag gag acg gcg gcc ttc       97
 Lys Ile Ala Leu His Asn Gln Lys Gln Ala Glu Glu Thr Ala Ala Phe
          15                  20                  25

 gag gag gtc atg aag gac ctg agc ctg acg cgg gcc gcg cgg ctc cag      145
 Glu Glu Val Met Lys Asp Leu Ser Leu Thr Arg Ala Ala Arg Leu Gln
      30                  35                  40

 ctc cag aaa tcc cag tac ctg caa ctg ggc ccc agc cga ggc cag tac      193
 Leu Gln Lys Ser Gln Tyr Leu Gln Leu Gly Pro Ser Arg Gly Gln Tyr
  45                  50                  55                  60

 tat ggc ggg tcc ctg ccc aac gtg aac cag atc ggg agt ggc acc atg      241
 Tyr Gly Gly Ser Leu Pro Asn Val Asn Gln Ile Gly Ser Gly Thr Met
                  65                  70                  75

 gac ctg ccc ttc cag ccc agc gga ttt ctg ggg gag gcc ctg gca gcg      289
 Asp Leu Pro Phe Gln Pro Ser Gly Phe Leu Gly Glu Ala Leu Ala Ala
              80                  85                  90

 gct cct gtc tct ctg acc ccc ttc caa tcc tcg ggc ctg gac acc agc      337
 Ala Pro Val Ser Leu Thr Pro Phe Gln Ser Ser Gly Leu Asp Thr Ser
          95                 100                 105

 cgg acc acc cgg cac cat ggg ctg gtg gac agg gtg tac cgg gag cgt      385
 Arg Thr Thr Arg His His Gly Leu Val Asp Arg Val Tyr Arg Glu Arg
     110                 115                 120

 ggc cgg ctc ggc tcc cca cac cgc cgg ccc ctg tca gtg gac aaa cac      433
 Gly Arg Leu Gly Ser Pro His Arg Arg Pro Leu Ser Val Asp Lys His
 125                 130                 135                 140

 gga cgg cag gcc gac agc tgc ccc tat ggc acc atg tac ctc tca cca      481
 Gly Arg Gln Ala Asp Ser Cys Pro Tyr Gly Thr Met Tyr Leu Ser Pro
                 145                 150                 155

 ccc gcg gac acc agc tgg aga agg acc aat tct gac tcc gcc ctg cac      529
 Pro Ala Asp Thr Ser Trp Arg Arg Thr Asn Ser Asp Ser Ala Leu His
             160                 165                 170

 cag agc aca atg acg ccc acg cag cca gaa tcc ttt agc agt ggg tcc      577
 Gln Ser Thr Met Thr Pro Thr Gln Pro Glu Ser Phe Ser Ser Gly Ser
         175                 180                 185

 cag gac gtg cac cag aaa aga gtc tta ctg tta aca gtc cca gga atg      625
 Gln Asp Val His Gln Lys Arg Val Leu Leu Leu Thr Val Pro Gly Met
     190                 195                 200

 gaa gag acc aca tca gag gca gac aaa aac ctt tcc aag caa gca tgg      673
 Glu Glu Thr Thr Ser Glu Ala Asp Lys Asn Leu Ser Lys Gln Ala Trp
 205                 210                 215                 220

 gac acc aag aag acg ggg tcc agg ccc aag tcc tgt gag gtc ccc gga      721
 Asp Thr Lys Lys Thr Gly Ser Arg Pro Lys Ser Cys Glu Val Pro Gly
                 225                 230                 235

 atc aac atc ttc ccg tct gcc gac cag gaa aac act aca gcc ctg atc      769
 Ile Asn Ile Phe Pro Ser Ala Asp Gln Glu Asn Thr Thr Ala Leu Ile
             240                 245                 250

 ccc gcc acc cac aac aca ggg ggg tcc ctg ccc gac ctg acc aac atc      817
 Pro Ala Thr His Asn Thr Gly Gly Ser Leu Pro Asp Leu Thr Asn Ile
         255                 260                 265

 cac ttc ccc tcc ccg ctc ccg acc ccg ctg gac ccc gag gag ccc acc      865
 His Phe Pro Ser Pro Leu Pro Thr Pro Leu Asp Pro Glu Glu Pro Thr
     270                 275                 280

 ttc cct gca ctg agc agc tcc agc agc acc ggc aac ctc gcg gcc aac      913
 Phe Pro Ala Leu Ser Ser Ser Ser Ser Thr Gly Asn Leu Ala Ala Asn
 285                 290                 295                 300

 ctg acg cac ctg ggc atc ggt ggc gcc ggc cag gga atg agc aca cct      961
 Leu Thr His Leu Gly Ile Gly Gly Ala Gly Gln Gly Met Ser Thr Pro
                 305                 310                 315

 ggc tcc tct cca cag cac cgc cca gct ggc gtc agc ccc ctg tcc ctg     1009
 Gly Ser Ser Pro Gln His Arg Pro Ala Gly Val Ser Pro Leu Ser Leu
             320                 325                 330

 agc aca gag gca agg cgt cag cag gca tcg ccc acc ctg tcc ccg ctg     1057
 Ser Thr Glu Ala Arg Arg Gln Gln Ala Ser Pro Thr Leu Ser Pro Leu
         335                 340                 345

 tca ccc atc act cag gct gta gcc atg gac gcc ctg tct ctg gag cag     1105
 Ser Pro Ile Thr Gln Ala Val Ala Met Asp Ala Leu Ser Leu Glu Gln
     350                 355                 360

 cag ctg ccc tac gcc ttc ttc acc cag gcg ggc tcc cag cag cca ccg     1153
 Gln Leu Pro Tyr Ala Phe Phe Thr Gln Ala Gly Ser Gln Gln Pro Pro
 365                 370                 375                 380

 ccg cag ccc cag ccc ccg ccg cct cct cca ccc gcg tcc cag cag cca     1201
 Pro Gln Pro Gln Pro Pro Pro Pro Pro Pro Pro Ala Ser Gln Gln Pro
                 385                 390                 395

 cca ccc ccg cca ccc cca cag gcg ccc gtc cgc ctg ccc cct ggt ggc     1249
 Pro Pro Pro Pro Pro Pro Gln Ala Pro Val Arg Leu Pro Pro Gly Gly
             400                 405                 410

 ccc ctg ttg ccc agc gcc agc ctg act cgt ggg cca cag ccg ccc ccg     1297
 Pro Leu Leu Pro Ser Ala Ser Leu Thr Arg Gly Pro Gln Pro Pro Pro
         415                 420                 425

 ctt gca gtc acg gta ccg tcc tct ctc ccc cag tcc ccc cca gag aac     1345
 Leu Ala Val Thr Val Pro Ser Ser Leu Pro Gln Ser Pro Pro Glu Asn
     430                 435                 440

 cct ggc cag cca tcg atg ggg atc gac atc gcc tcg gcg ccg gct ctg     1393
 Pro Gly Gln Pro Ser Met Gly Ile Asp Ile Ala Ser Ala Pro Ala Leu
 445                 450                 455                 460

 cag cag tac cgc act agc gcc ggc tcc ccg gcc aac cag tct ccc acc     1441
 Gln Gln Tyr Arg Thr Ser Ala Gly Ser Pro Ala Asn Gln Ser Pro Thr
                 465                 470                 475

 tcg cca gtc tcc aat caa ggc ttc tcc cca ggg agc tcc ccg caa cac     1489
 Ser Pro Val Ser Asn Gln Gly Phe Ser Pro Gly Ser Ser Pro Gln His
             480                 485                 490

 act tcc acc ctg ggc agc gtg ttt ggg gac gcg tac tat gag cag cag     1537
 Thr Ser Thr Leu Gly Ser Val Phe Gly Asp Ala Tyr Tyr Glu Gln Gln
         495                 500                 505

 atg gcg gcc agg cag gcc aat gct ctg tcc cac cag ctg gag cag ttc     1585
 Met Ala Ala Arg Gln Ala Asn Ala Leu Ser His Gln Leu Glu Gln Phe
     510                 515                 520

 aac atg atg gag aac gcc atc agc tcc agc agc ctg tac agc ccg ggc     1633
 Asn Met Met Glu Asn Ala Ile Ser Ser Ser Ser Leu Tyr Ser Pro Gly
 525                 530                 535                 540

 tcc aca ctc aac tac tcg cag gcg gcc atg atg ggc ctc acg ggc agc     1681
 Ser Thr Leu Asn Tyr Ser Gln Ala Ala Met Met Gly Leu Thr Gly Ser
                 545                 550                 555

 cac ggg agc ctg ccg gac tcg cag caa ctg gga tac gcc agc cac agt     1729
 His Gly Ser Leu Pro Asp Ser Gln Gln Leu Gly Tyr Ala Ser His Ser
             560                 565                 570

 ggc atc ccc aac atc atc ctc aca gtg aca gga gag tcc ccc ccc agc     1777
 Gly Ile Pro Asn Ile Ile Leu Thr Val Thr Gly Glu Ser Pro Pro Ser
         575                 580                 585

 ctc tct aaa gaa ctg acc agc tct ctg gcc ggg gtc ggc gac gtc agc     1825
 Leu Ser Lys Glu Leu Thr Ser Ser Leu Ala Gly Val Gly Asp Val Ser
     590                 595                 600

 ttc gac tcc gac agc cag ttt ccc ctg gac gaa ctc aag atc gac ccc     1873
 Phe Asp Ser Asp Ser Gln Phe Pro Leu Asp Glu Leu Lys Ile Asp Pro
 605                 610                 615                 620

 ctg acc ctc gac gga ctg cac atg ctc aac gac ccc gac atg gtt ctg     1921
 Leu Thr Leu Asp Gly Leu His Met Leu Asn Asp Pro Asp Met Val Leu
                 625                 630                 635

 gcc gac cca gcc acc gag gac acc ttc cgg atg gac cgc ctg tgagcgg     1970
 Ala Asp Pro Ala Thr Glu Asp Thr Phe Arg Met Asp Arg Leu 
             640                 645                 650

 gcacgccggc accctgccgc tcagccgtcc cgacggcgcc tccccagccc ggggacggcc   2030

 gtgctccgtc cctcgccaac ggccgagctt gtgattctga gcttgcaatg ccgccaagcg   2090

 ccccccgcca gcccgccccc ggttgtccac ctcccgcgaa gcccaatcgc gaggccgcga   2150

 gccgggccgt ccacccaccc gcccgcccag ggctgggctg ggatcggagg ccgtgagcct   2210

 cccgcccctg cagaccctcc ctgcactggc tccctcgccc ccagccccgg ggcctgagcc   2270

 gtcccctgta agatgcggga agtgtcagct cccggcgtgg cgggcaggct caggggaggg   2330

 gcgcgcatgg tccgccaggg ctgtgggccg tggcgcattt tccgactgtt tgtccagctc   2390

 tcactgcctt ccttggttcc cggtccccca gcccatccgc catccccagc ccgtggtcag   2450

 gtagagagtg agccccacgc cgccccaggg aggaggcgcc agagcgcggg gcagacgcaa   2510

 agtgaaataa acactatttt gacggctgtc ttttatattt ctgagcacac acagagccct   2570

 ggcgtccacc ggggcaggcg caaagtggac agagcatgca gggcggcgga cccccccacg   2630

 accctcctcg ccctgtctcc atcccctcga agccctgcct caccgcaggc aggcccatcg   2690

 gtggccacct ttgccgggaa gtgaccggaa ggccccgtga ggggtcgaac gcggaggcag   2750

 gggttacctc ttggggcttt acaatccgtg gcccctcctg tcctgcactg tggtcaccgg   2810

 tcctgtcata gatgctgtta atttaaggta caggcagagg tggccagggg agtttcattg   2870

 tggtttttct ttccttttag tttctagtta cattttggtt gtagatgact cgcttaatct   2930

 tttaagccaa cacttgcctg agagcatgtt tttatttcag aaatccaact ttacctattt   2990

 tttaagctaa ctggaaatgg aggccatgcg ccccaaagca gcccgccacc cacctgagtg   3050

 taagaagtga gtccggcttt tgggtttcac cccaagttat ctcaaaacaa aagggctggt   3110

 caggctgggc agggccttgt caggagctca cggtaggcag aggtgcctct gccagggcca   3170

 cagaacagac ttccgggaag gggccttggc ttttattgag ggtctctcaa agacccagcc   3230

 tgccagcctc tcccagaggt gcctgctagt ccttagagtg tgtgtgtgaa gatgccatga   3290

 ccagtggcag ctgagacctc tctgccccaa gagtgtgggg gactggcagg gagcgagggt   3350

 ccccgagacg aggaccacgg tcctccctga gaacctgggt ggaactggca tttcatcccc   3410

 tctccaccct accctctggc tcctagccca caccccctct cttgggcagc gtggtctgct   3470

 ggctgcccct tcttggcagc tcagggtcgt ggcaggtgga cttggagaca cacagcagtg   3530

 tgtgttttag tggcaggttt caggagcacc tctaagacca gggtgacagg gtacttggga   3590

 gctgtcctgg accctcccca taccacgggc cctgcaaggg aggcatcagg gctggctttg   3650

 ttttctgctg ttcttggaat aggaactgct gttctgatcc ccccaaaact gcattgcggc   3710

 tctcgctcgc tcctgcctgc cgggacagcg ccttctgctg agtccgttta tttgtagtgt   3770

 catggctgct gctttcactg gggtcctggg caccctggct tctgtcctca gagctgggtt   3830

 tgatcctagc aaccatccct tcctctcttt gcccggcaat gcctttggca tgtgtctgag   3890

 cagccaagtg gccactcata ggagaaggct ccctggtcac gttgctcctg ctgccgtctt   3950

 gttccaaggt gcggggggga cactgttggt ctgtccaggt caaggtccct ttctcttacc   4010

 atgacagagg ctgggggcag acagcgggga cttttttttt tttttaagaa aaactacatg   4070

 tacataggag agtttcatta ccattagact tgtatgtagg acttaaaaaa aaatggcctt   4130

 aataaaatta caagcaaccc gcctggatgc ggttttcaaa agaaggcatt gaggaccatg   4190

 ctaggaaacc tcatacccca tccgtccaac ctccggcggg cgccactgct tgtcctctgg   4250

 tcttcggtgt ggacagatag gagaggaggg atgcccacct cggagcatcc caggcccgtg   4310

 gcccattttc agcatcctga agccagattc acagtgacat tgtgttaacg tgacgacctt   4370

 ggtccattat ggagttcttt ttccaataag aacctggtgg accgaggtcc gagcttgcca   4430

 gggacagtgg ggcccacgcg agtacccggg gcccagccag gagccagcag ccaggcgtcc   4490

 ctgtgttcca gaaggattca cgcccctcct ggacctgggc gggcctccca gggggtctgt   4550

 atcacggcct tttgtgtgtg cgtacgtgtg gtttttttaa atatcactac tacatattct   4610

 tgaattgcca agactttctg aaacaagaca gcttaaggga atcagccttt tgctttgtga   4670

 tgtgaaaata ctgtgatttg acgagccgct tcctgagggg caggcccacg tggggaggtt   4730

 gcgccgtgta catagacccg ccgtctgtgt ccttggtcag gcccggatgc ttggtctaca   4790

 ctgggttaga ggctgctctc cccacgcacc catgtgctca tggcttctgc agaccctctg   4850

 ctgggtacat cggtccccta cggcgaagtt cagccagggc tctccctcct gagagcatgg   4910

 cgtccccacc ttcctgtttc gccgacgtca ctacccaggg tggcaagtct tgcaggcaga   4970

 gggtgtagcc caagttcagc ctctctctgt gtcctccaga gaagagggtt ctttgccctc   5030

 atcagggccc tgcttgtggg ttttcggctc tggggaggag agtgttggca tcagtgtgtt   5090

 tggcctgatt tcttcagggg gccaagctcc cgggaggacc cctagccagg agggcccccc   5150

 atgtccatcc atccctcctg ctggggcttg gatgtcaggc ttgggggctg tgagctggga   5210

 cctcgcctga gcccggtcag gtgggacagg agcctgccag aagcccatgg ggggccaggc   5270

 cgggtggctt ctattttatt tttttagaga tggggtcttg ctgtgttgcc caggctggtc   5330

 tcggactcct gggctcaagc agtcctccct cctcggcctc ccaaagttct ggggctacag   5390

 gtgtgagcca cttctgccca gcatcccagg cctgaacagc cttggcagga cccgtcccta   5450

 gagggggctc tggtgcctcc cttaggtggg ccttgagctg gtttttaacc aaacatcctt   5510

 ccaaactcgg gctgcgacct gcttcctgag ttttctgtat ttccaaggag ccctccgacc   5570

 agggagaggc tggtggagta aggtccagcg gtattcgggg gtcctctgtc acctcgccct   5630

 gaaaacagca gctcccatca ccttcactgg gtcccgatgg agccgtctca gaggccgagg   5690

 ggccctctgt gtgggggtgg gacgcagggg ctctcagagc aagggccaca aagccgatgg   5750

 cacagatgtg cccctgggcc tggcccgtca cccacatgtg gtgccctggg ccagggcgtg   5810

 cgggcgccag agccttccct acacagccta agagcagggg caagactcgg cccctcactc   5870

 accctgggag gcctgcctgg gctacatgga cacctgggtc tctttctacc cccattcacc   5930

 atggaccagg ggcctccatt tcctgggggc tcttgcggca tgtgatttgg gggtccctgg   5990

 gacattctcc cgtcagctcc acctgagcca agtgtcctgt tccctgcggc ccttggcctt   6050

 ccagggtcct ggccaggcag gggtcaggca ccccatactc ttccgtgtgg cacaggtgtc   6110

 cacccacccc cactggccac agacaccatt ctccccctgg gagcaggagg tggagtaagt   6170

 tgtaccccca ggcctgggtg ctggggagtt cctgagggca tgggtggggc aggagtgagt   6230

 gcctcgtgat cccagcctca gtttctctct tgtcactttc tcaaacctgc aggtctcagg   6290

 gccccgggct cctcctgggc aggatggggg gcaggggctg ggccttgggg tggtgctggc   6350

 tctgatgatt ccagagcctg tatccacctt ctgggctcct ggccagcacc ccacccccag   6410

 gagccaggga caggtggcat gtgttggggt cgggggatgg cccccatctc gaagtgttct   6470

 ggaatttggg ggcaaccctt gcccagccca gacatcaaga acttctgatc tcctgcccac   6530

 caggagggga cttagccatg gacttggcca gtaggcctgg ggagggaggg ctttggcagc   6590

 caaagtccac tggccctgcc gtgcccctga gtaggaaact gtcccctagg ggctgggtgg   6650

 ccccactgat atatgcaaac ccgccggtcc gagccctgtt cctgcctgtg ctcctctgtg   6710

 cccaggctgg ctctccccca accctagcat gtatactctg ccacggacgt cccgtgggcc   6770

 atgattgtg                                                           6779




      <210> 149
      <211> 2235
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (258)..(668)

      <400> 149
 taagcttgcg gccgccccgg ccgcccccgc gggggacacc tcctcgccgc cacagcttta     60

 ggaaacacct ctacctcctg cgaggcctcc cgggctccgg gaaaactaca ctggccagac    120

 aattgcagca tgactttccc agggccctga ttttcagcac ggatgatttt ttcttcaggg    180

 aagatggtgc ctatgagttc aatcctgact tcctggagga agctcatgaa tggaaccaaa    240

 aaagagcaag aaaagca   atg agg aat ggc ata tcc ccc att att att gat     290
                      Met Arg Asn Gly Ile Ser Pro Ile Ile Ile Asp
                        1               5                  10

 aat acc aac ctc cac gcc tgg gaa atg aag ccc tat gca gtc atg gca      338
 Asn Thr Asn Leu His Ala Trp Glu Met Lys Pro Tyr Ala Val Met Ala
              15                  20                  25

 ctt gaa aat aac tat gaa gtt ata ttc cga gaa cct gac act cgc tgg      386
 Leu Glu Asn Asn Tyr Glu Val Ile Phe Arg Glu Pro Asp Thr Arg Trp
          30                  35                  40

 aaa ttc aac gtt caa gag tta gca aga aga aac att cat ggt gtc tca      434
 Lys Phe Asn Val Gln Glu Leu Ala Arg Arg Asn Ile His Gly Val Ser
      45                  50                  55

 aga gaa aaa atc cac cga atg aaa gaa cgg tat gaa cac gat gtt act      482
 Arg Glu Lys Ile His Arg Met Lys Glu Arg Tyr Glu His Asp Val Thr
  60                  65                  70                  75

 ttt cac agt gtg ctt cat gca gaa aag cca agc aga atg aac aga aac      530
 Phe His Ser Val Leu His Ala Glu Lys Pro Ser Arg Met Asn Arg Asn
                  80                  85                  90

 cag gac agg aat aat gca ttg cct tcc aac aat gcc aga tac tgg aat      578
 Gln Asp Arg Asn Asn Ala Leu Pro Ser Asn Asn Ala Arg Tyr Trp Asn
              95                 100                 105

 tcc tac aca gag ttt cca aac cgg agg gcc cac ggt gga ttt aca aat      626
 Ser Tyr Thr Glu Phe Pro Asn Arg Arg Ala His Gly Gly Phe Thr Asn
         110                 115                 120

 gag agc tcc tat cac aga agg ggc ggt tgt cac cat gga tat tagaggc      675
 Glu Ser Ser Tyr His Arg Arg Gly Gly Cys His His Gly Tyr 
     125                 130                 135

 ctatcttaca gccaggcaga attttcctaa gtcagtttct acttcagttt ttgttatttt    735

 ttgttgcatt ttagtcagag ctccaattcc agtgtaaata gctgaactca aaagtttctg    795

 agcaaagtca ttatattcac tttcttcacc aaaatttgtt aaagtgcttc tatatgcatg    855

 gtctgatgct gggaattctg cagatttgag taaacagtct ctttctctag ggtaagaatt    915

 tgaaaccaaa acttgagaac acacccaaga atatatttac ataggttcat agatgaaata    975

 aagtgtttat attatatata agcttcagta ccatttgctc tgaagtgatc tatttatttt   1035

 ttcaggaaat tcatctccat cggtaaagtt gggaaggtgg agagaagtgg tgggggggca   1095

 ttgctactta tcaaagtgcc attgctactt tgataatcta tgtatctaaa aatgtgagat   1155

 gtgcgactct tatgatactg attttccttt aatgttaata tgccagaaag catacatcta   1215

 agggaacatt gtccttcaaa gtagacactt tgggaagtta tttctttatt ttaatgatgt   1275

 atcattgtta aaaatgctgt caaatcctta atagctacag gagctactga gggaaatcag   1335

 tgtcattatt taaagtcacg ccttgtgttt ttactacttt attcagcagg attaaacctg   1395

 aataactttt ggctgttgtg ctaatagtgt aaataaaata agcctgcctt cataaaacac   1455

 taacttttaa aaggaataaa cgacttctaa aattatgcct attaacatgt gtaattagtc   1515

 ggcagctcaa atgtttggga gtgcaagaaa ttaggcaccc caggatatag gtcatacagg   1575

 gatatataaa agccatgctc attacaaaat gagcagttga tgttttatgt ggcattaaga   1635

 caatcaagtc ctcacaactc tggaatgtct tcttatactg atgctgaatt tatgaatcca   1695

 aattaatttc caacaggttg gaatcagatt taatgtgaga tcatgataga caagaccaca   1755

 gaggacgtat gctctatttc ttgttggcca acagcttctt tctaatgttc tgtgaaaaat   1815

 tattttaagt gtcttatata atggtgcttt tatggttatt aaaaattgta aatggtatca   1875

 catttatatg gatttgtcat tggatctttt tttggttcaa caataaaaaa atttaattac   1935

 ctaaatgcca agaaactcaa caatatacca gtttttctgt atcacaggct tatttaccag   1995

 tctttttttt aataaatagg aatcgtaaag gtaatgacaa aagcagcctt ataatttagt   2055

 tgcttatata tttgatctgt gtacatgaga ctgttttaac gttatctgac actactgaaa   2115

 cctgctcgac atctccatga ctaccaacac catgtgtaat gttttcttca ctaacatttt   2175

 aaaaactggt atctcctttg agtaagtttg gctgacaata gtaaatccca atgaatctaa   2235




      <210> 150
      <211> 4348
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (349)..(4302)

      <400> 150
 ttcaaggtca cgggccgtgc cagtccctac ccctagtgcc ccgcagcgtg ccagcccact     60

 gatgccggca ggccgttacg ctatgcctgt ggcagcctcc cacctgggag aggactggcg    120

 gccacgaggg caacttcgtg ggagaggtgg tggcgggctc ggggttcaga ggctgaagct    180

 gggtcgcagc tcgaccgggg cgctgatctg tggctgtccg ttccttgctg gagaatttgg    240

 ccacaaagag ctgccaagat agctgggcca ggaagaaagc gccgcagccc tgacccagac    300

 gctgttgccg accccggggc actctggctg tcgaccaagc ggctcaag atg tct ggc     357
                                                      Met Ser Gly
                                                        1

 ggg gcc agt gcc aca ggc cca agg aga ggg ccc cca gga ctg gag gac      405
 Gly Ala Ser Ala Thr Gly Pro Arg Arg Gly Pro Pro Gly Leu Glu Asp
       5                  10                  15

 acc act agt aag aag aag cag aag gat cga gca aac cag gag agc aag      453
 Thr Thr Ser Lys Lys Lys Gln Lys Asp Arg Ala Asn Gln Glu Ser Lys
  20                  25                  30                  35

 gat gga gat cct agg aaa gag aca ggg tct cga tat gtt gcc cag gct      501
 Asp Gly Asp Pro Arg Lys Glu Thr Gly Ser Arg Tyr Val Ala Gln Ala
                  40                  45                  50

 ggt ctt gaa cct ctg gcc tca ggt gat cct tct gcc tca gcc tcc cat      549
 Gly Leu Glu Pro Leu Ala Ser Gly Asp Pro Ser Ala Ser Ala Ser His
              55                  60                  65

 gca gct ggg atc aca ggc tca cgc cac cgt acc cgg ctg ttc ttt cct      597
 Ala Ala Gly Ile Thr Gly Ser Arg His Arg Thr Arg Leu Phe Phe Pro
          70                  75                  80

 tca tcg tca ggg tca gca tcc act cct caa gag gag cag acc aaa gag      645
 Ser Ser Ser Gly Ser Ala Ser Thr Pro Gln Glu Glu Gln Thr Lys Glu
      85                  90                  95

 gga gct tgt gaa gac cct cat gat ctc ttg gct act ccc act cca gag      693
 Gly Ala Cys Glu Asp Pro His Asp Leu Leu Ala Thr Pro Thr Pro Glu
 100                 105                 110                 115

 ttg ttg ctc gat tgg agg cag agt gca gaa gag gtg att gtc aag ctt      741
 Leu Leu Leu Asp Trp Arg Gln Ser Ala Glu Glu Val Ile Val Lys Leu
                 120                 125                 130

 cgt gtg gga gta ggt ccc ctg cag ctg gag gat gta gat gct gct ttc      789
 Arg Val Gly Val Gly Pro Leu Gln Leu Glu Asp Val Asp Ala Ala Phe
             135                 140                 145

 aca gat aca gac tgt gtg gtg cgg ttt gca ggt ggt cag cag tgg ggt      837
 Thr Asp Thr Asp Cys Val Val Arg Phe Ala Gly Gly Gln Gln Trp Gly
         150                 155                 160

 ggt gtc ttc tat gct gag ata aaa agc tct tgt gct aaa gtg caa acc      885
 Gly Val Phe Tyr Ala Glu Ile Lys Ser Ser Cys Ala Lys Val Gln Thr
     165                 170                 175

 cgc aag ggc agt ctc ctg cac ctg aca ctg ccc aaa aag gtg cct atg      933
 Arg Lys Gly Ser Leu Leu His Leu Thr Leu Pro Lys Lys Val Pro Met
 180                 185                 190                 195

 ctc acg tgg ccc tcc ctc ctg gtt gag gct gat gaa cag ctt tgc ata      981
 Leu Thr Trp Pro Ser Leu Leu Val Glu Ala Asp Glu Gln Leu Cys Ile
                 200                 205                 210

 cca ccg ctg aac tcc caa acc tgc ctc ctg ggc tca gag gag aat tta     1029
 Pro Pro Leu Asn Ser Gln Thr Cys Leu Leu Gly Ser Glu Glu Asn Leu
             215                 220                 225

 gcc cct ttg gca gga gag aaa gca gtg cct ccc ggg aat gac cca gtc     1077
 Ala Pro Leu Ala Gly Glu Lys Ala Val Pro Pro Gly Asn Asp Pro Val
         230                 235                 240

 tct cca gcc atg gtc cgg agc aga aac cct ggg aaa gat gac tgt gcc     1125
 Ser Pro Ala Met Val Arg Ser Arg Asn Pro Gly Lys Asp Asp Cys Ala
     245                 250                 255

 aag gag gag atg gca gtg gca gca gat gct gca acc ttg gtg gat gag     1173
 Lys Glu Glu Met Ala Val Ala Ala Asp Ala Ala Thr Leu Val Asp Glu
 260                 265                 270                 275

 ccc gag tcg atg gtg aac ctg gcg ttt gtc aag aat gac tcg tat gag     1221
 Pro Glu Ser Met Val Asn Leu Ala Phe Val Lys Asn Asp Ser Tyr Glu
                 280                 285                 290

 aag ggc ccg gat tca gtg gtg gtg cac gtg tac gtg aag gag atc tgc     1269
 Lys Gly Pro Asp Ser Val Val Val His Val Tyr Val Lys Glu Ile Cys
             295                 300                 305

 agg gac acc tca aga gta ctt ttc cgt gag cag gac ttc acg ctc atc     1317
 Arg Asp Thr Ser Arg Val Leu Phe Arg Glu Gln Asp Phe Thr Leu Ile
         310                 315                 320

 ttc cag acc agg gat gga aac ttc ctg agg ctg cac ccg ggc tgt ggg     1365
 Phe Gln Thr Arg Asp Gly Asn Phe Leu Arg Leu His Pro Gly Cys Gly
     325                 330                 335

 ccc cac acc acc ttc cgt tgg cag gtg aag ctc agg aat ctg att gag     1413
 Pro His Thr Thr Phe Arg Trp Gln Val Lys Leu Arg Asn Leu Ile Glu
 340                 345                 350                 355

 cca gag cag tgc acc ttc tgt ttc acg gct tct cgc atc gac atc tgc     1461
 Pro Glu Gln Cys Thr Phe Cys Phe Thr Ala Ser Arg Ile Asp Ile Cys
                 360                 365                 370

 ctt cgt aag agg cag agt cag cgc tgg ggg ggc ctg gag gcc ccg gct     1509
 Leu Arg Lys Arg Gln Ser Gln Arg Trp Gly Gly Leu Glu Ala Pro Ala
             375                 380                 385

 gca cga gtg ggt ggt gca aag gtt gcc gtg ccg aca ggt cca acc cct     1557
 Ala Arg Val Gly Gly Ala Lys Val Ala Val Pro Thr Gly Pro Thr Pro
         390                 395                 400

 ctg gat tca acc cca cca gga ggt gct ccc cac ccc ctg aca ggc cag     1605
 Leu Asp Ser Thr Pro Pro Gly Gly Ala Pro His Pro Leu Thr Gly Gln
     405                 410                 415

 gag gag gcc cgg gct gtg gag aag gat aaa tcc aag gca cga tct gag     1653
 Glu Glu Ala Arg Ala Val Glu Lys Asp Lys Ser Lys Ala Arg Ser Glu
 420                 425                 430                 435

 gac aca ggg cta gac agt gtg gca acc cgc aca ccc atg gag cat gta     1701
 Asp Thr Gly Leu Asp Ser Val Ala Thr Arg Thr Pro Met Glu His Val
                 440                 445                 450

 acc cca aag cca gag aca cac ctg gcc tcg ccc aag cct aca tgc atg     1749
 Thr Pro Lys Pro Glu Thr His Leu Ala Ser Pro Lys Pro Thr Cys Met
             455                 460                 465

 gtg cct ccc atg ccc cac agc cca gtt agt gga gac agc gtg gag gag     1797
 Val Pro Pro Met Pro His Ser Pro Val Ser Gly Asp Ser Val Glu Glu
         470                 475                 480

 gag gaa gag gaa gag aag aag gtg tgt ctg cca ggc ttc act ggc ctt     1845
 Glu Glu Glu Glu Glu Lys Lys Val Cys Leu Pro Gly Phe Thr Gly Leu
     485                 490                 495

 gtc aat tta ggc aac acc tgc ttc atg aac agc gtc att cag tct ctg     1893
 Val Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Val Ile Gln Ser Leu
 500                 505                 510                 515

 tcc aac act cgg gaa ctc cgg gac ttc ttc cat gac cgc tcc ttt gag     1941
 Ser Asn Thr Arg Glu Leu Arg Asp Phe Phe His Asp Arg Ser Phe Glu
                 520                 525                 530

 gct gag atc aac tac aac aac cca cta ggg act ggt ggg cgt ctg gcc     1989
 Ala Glu Ile Asn Tyr Asn Asn Pro Leu Gly Thr Gly Gly Arg Leu Ala
             535                 540                 545

 att ggc ttt gcc gtg ctg ctt cgg gcg ctg tgg aag ggc acc cac cat     2037
 Ile Gly Phe Ala Val Leu Leu Arg Ala Leu Trp Lys Gly Thr His His
         550                 555                 560

 gcc ttc cag cct tcc aag ttg aag gcc att gtg gcg agt aag gcc agc     2085
 Ala Phe Gln Pro Ser Lys Leu Lys Ala Ile Val Ala Ser Lys Ala Ser
     565                 570                 575

 cag ttc aca ggc tat gca cag cat gat gcc cag gag ttc atg gct ttc     2133
 Gln Phe Thr Gly Tyr Ala Gln His Asp Ala Gln Glu Phe Met Ala Phe
 580                 585                 590                 595

 ctg ctg gat ggg ctg cac gag gac ctg aat cgc att cag aac aag ccc     2181
 Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Ile Gln Asn Lys Pro
                 600                 605                 610

 tac aca gag acc gtg gat tca gat ggg cgg ccc gat gag gtg gta gct     2229
 Tyr Thr Glu Thr Val Asp Ser Asp Gly Arg Pro Asp Glu Val Val Ala
             615                 620                 625

 gag gaa gca tgg cag cgg cac aag atg agg aat gac tct ttc atc gtg     2277
 Glu Glu Ala Trp Gln Arg His Lys Met Arg Asn Asp Ser Phe Ile Val
         630                 635                 640

 gac cta ttt cag ggg cag tac aag tcg aag ctg gtg tgc cct gtg tgt     2325
 Asp Leu Phe Gln Gly Gln Tyr Lys Ser Lys Leu Val Cys Pro Val Cys
     645                 650                 655

 gcc aag gtc tcc atc act ttt gac ccg ttt ctt tat ctg ccg gtg ccc     2373
 Ala Lys Val Ser Ile Thr Phe Asp Pro Phe Leu Tyr Leu Pro Val Pro
 660                 665                 670                 675

 ttg cca caa aag caa aag gtt ctc cct gtc ttt tat ttt gcc cga gag     2421
 Leu Pro Gln Lys Gln Lys Val Leu Pro Val Phe Tyr Phe Ala Arg Glu
                 680                 685                 690

 ccc cac agc aag ccc atc aag ttc ctg gtg agc gtc agc aag gag aac     2469
 Pro His Ser Lys Pro Ile Lys Phe Leu Val Ser Val Ser Lys Glu Asn
             695                 700                 705

 tcc act gcg agc gaa gta ttg gac tcc ctc tct cag agt gtt cat gtg     2517
 Ser Thr Ala Ser Glu Val Leu Asp Ser Leu Ser Gln Ser Val His Val
         710                 715                 720

 aag cct gag aac ctg cgt ttg gcg gag gta att aag aat cgt ttt cat     2565
 Lys Pro Glu Asn Leu Arg Leu Ala Glu Val Ile Lys Asn Arg Phe His
     725                 730                 735

 cgt gtg ttc cta ccc tcc cac tca ctg gac act gtg tcc cca tct gat     2613
 Arg Val Phe Leu Pro Ser His Ser Leu Asp Thr Val Ser Pro Ser Asp
 740                 745                 750                 755

 acg ctc ctc tgc ttt gag ctg cta tcc tca gag ttg gct aag gag cgg     2661
 Thr Leu Leu Cys Phe Glu Leu Leu Ser Ser Glu Leu Ala Lys Glu Arg
                 760                 765                 770

 gta gtg gtg cta gag gtg caa cag cgc ccc cag gtg ccc agc gtc ccc     2709
 Val Val Val Leu Glu Val Gln Gln Arg Pro Gln Val Pro Ser Val Pro
             775                 780                 785

 atc tcc aag tgt gca gcc tgc cag cgg aag caa cag tcg gag gat gaa     2757
 Ile Ser Lys Cys Ala Ala Cys Gln Arg Lys Gln Gln Ser Glu Asp Glu
         790                 795                 800

 aag ctg aag cgc tgt acc cgg tgc tac cgt gtg ggc tac tgc aac cag     2805
 Lys Leu Lys Arg Cys Thr Arg Cys Tyr Arg Val Gly Tyr Cys Asn Gln
     805                 810                 815

 ctc tgc cag aaa acc cac tgg cct gac cac aag ggc ctc tgc cga cct     2853
 Leu Cys Gln Lys Thr His Trp Pro Asp His Lys Gly Leu Cys Arg Pro
 820                 825                 830                 835

 gag aac att ggc tac ccc ttc ctg gtc agt gta cct gcc tca cgc ctc     2901
 Glu Asn Ile Gly Tyr Pro Phe Leu Val Ser Val Pro Ala Ser Arg Leu
                 840                 845                 850

 act tat gcc cgc ctc gct cag ttg cta gag ggc tat gcc cgg tac tct     2949
 Thr Tyr Ala Arg Leu Ala Gln Leu Leu Glu Gly Tyr Ala Arg Tyr Ser
             855                 860                 865

 gtg agt gta ttc cag cca ccc ttt cag cca ggc cgc atg gcc ttg gag     2997
 Val Ser Val Phe Gln Pro Pro Phe Gln Pro Gly Arg Met Ala Leu Glu
         870                 875                 880

 tct cag agc cct ggc tgc acc aca ctg ctc tcc aca ggt tcc ctg gag     3045
 Ser Gln Ser Pro Gly Cys Thr Thr Leu Leu Ser Thr Gly Ser Leu Glu
     885                 890                 895

 gct ggg gac agc gag aga gac ccc att cag cca cct gag ctc cag ctg     3093
 Ala Gly Asp Ser Glu Arg Asp Pro Ile Gln Pro Pro Glu Leu Gln Leu
 900                 905                 910                 915

 gtg acc cct atg gct gag ggg gac aca ggg ctt ccc cgg gtg tgg gca     3141
 Val Thr Pro Met Ala Glu Gly Asp Thr Gly Leu Pro Arg Val Trp Ala
                 920                 925                 930

 gcc cct gac cgg ggt cct gtg ccc agc acc agt gga att tct tct gag     3189
 Ala Pro Asp Arg Gly Pro Val Pro Ser Thr Ser Gly Ile Ser Ser Glu
             935                 940                 945

 atg ctg gcc agt ggg ccc att gag gtt ggc tcc ttg cca gct ggc gag     3237
 Met Leu Ala Ser Gly Pro Ile Glu Val Gly Ser Leu Pro Ala Gly Glu
         950                 955                 960

 agg gtg tcc cga ccc gaa gct gct gtg cct ggg tac cag cat cca agt     3285
 Arg Val Ser Arg Pro Glu Ala Ala Val Pro Gly Tyr Gln His Pro Ser
     965                 970                 975

 gaa gct atg aat gcc cac aca ccc cag ttc ttc atc tat aaa att gat     3333
 Glu Ala Met Asn Ala His Thr Pro Gln Phe Phe Ile Tyr Lys Ile Asp
 980                 985                 990                 995

 tca tcc aac cga gag cag cgg cta gag gac aaa gga gac acc cca ctg     3381
 Ser Ser Asn Arg Glu Gln Arg Leu Glu Asp Lys Gly Asp Thr Pro Leu
                1000                1005                1010

 gag ctg ggt gac gac tgt agc ctg gct ctc gtc tgg cgg aac aat gag     3429
 Glu Leu Gly Asp Asp Cys Ser Leu Ala Leu Val Trp Arg Asn Asn Glu
            1015                1020                1025

 cgc ttg cag gag ttt gtg ttg gta gcc tcc aag gag ctg gaa tgt gct     3477
 Arg Leu Gln Glu Phe Val Leu Val Ala Ser Lys Glu Leu Glu Cys Ala
        1030                1035                1040

 gag gat cca ggc tct gcc ggt gag gct gcc cgg gcc ggc cac ttc acc     3525
 Glu Asp Pro Gly Ser Ala Gly Glu Ala Ala Arg Ala Gly His Phe Thr
    1045                1050                1055

 ctg gac cag tgc ctc aac ctc ttc aca cgg cct gag gtg ctg gca ccc     3573
 Leu Asp Gln Cys Leu Asn Leu Phe Thr Arg Pro Glu Val Leu Ala Pro
1060                1065                1070                1075

 gag gag gcc tgg tac tgc cca cag tgc aaa cag cac cgt gag gcc tcc     3621
 Glu Glu Ala Trp Tyr Cys Pro Gln Cys Lys Gln His Arg Glu Ala Ser
                1080                1085                1090

 aag cag ctg ttg cta tgg cgc ctg cca aat gtt ctc atc gtg cag ctc     3669
 Lys Gln Leu Leu Leu Trp Arg Leu Pro Asn Val Leu Ile Val Gln Leu
            1095                1100                1105

 aag cgc ttc tcc ttt cgt agt ttt atc tgg cgt gac aag atc aat gac     3717
 Lys Arg Phe Ser Phe Arg Ser Phe Ile Trp Arg Asp Lys Ile Asn Asp
        1110                1115                1120

 ttg gtg gag ttc cct gtt agg aac ctg gac ctg agc aag ttc tgc att     3765
 Leu Val Glu Phe Pro Val Arg Asn Leu Asp Leu Ser Lys Phe Cys Ile
    1125                1130                1135

 ggt cag aaa gag gag cag ctg ccc agc tac gat cta tat gct gtc atc     3813
 Gly Gln Lys Glu Glu Gln Leu Pro Ser Tyr Asp Leu Tyr Ala Val Ile
1140                1145                1150                1155

 aac cac tat gga ggc atg att ggt ggc cac tac act gcc tgt gca cgc     3861
 Asn His Tyr Gly Gly Met Ile Gly Gly His Tyr Thr Ala Cys Ala Arg
                1160                1165                1170

 ctg ccc aat gat cgt agc agt cag cgc agt gac gtg ggc tgg cgc ttg     3909
 Leu Pro Asn Asp Arg Ser Ser Gln Arg Ser Asp Val Gly Trp Arg Leu
            1175                1180                1185

 ttt gat gac agc aca gtg aca acg gta gac gag agc cag gtt gtg acg     3957
 Phe Asp Asp Ser Thr Val Thr Thr Val Asp Glu Ser Gln Val Val Thr
        1190                1195                1200

 cgt tat gcc tat gta ctc ttc tac cgc cgg cgg aac tct cct gtg gag     4005
 Arg Tyr Ala Tyr Val Leu Phe Tyr Arg Arg Arg Asn Ser Pro Val Glu
    1205                1210                1215

 agg ccc ccc agg gca ggt cac tct gag cac cac cca gac cta ggc cct     4053
 Arg Pro Pro Arg Ala Gly His Ser Glu His His Pro Asp Leu Gly Pro
1220                1225                1230                1235

 gca gct gag gct gct gcc agc cag gct tcc cgg att tgg cag gag ctg     4101
 Ala Ala Glu Ala Ala Ala Ser Gln Ala Ser Arg Ile Trp Gln Glu Leu
                1240                1245                1250

 gag gct gag gag gag ccg gtg cct gag ggg tct ggg ccc ctg ggt ccc     4149
 Glu Ala Glu Glu Glu Pro Val Pro Glu Gly Ser Gly Pro Leu Gly Pro
            1255                1260                1265

 tgg ggg ccc caa gac tgg gtg ggc ccc cta cca cgt ggc cct acc aca     4197
 Trp Gly Pro Gln Asp Trp Val Gly Pro Leu Pro Arg Gly Pro Thr Thr
        1270                1275                1280

 cca gat gag ggc tgc ctc cgg tac ttt gtc ctg ggc acc gtg gcg gct     4245
 Pro Asp Glu Gly Cys Leu Arg Tyr Phe Val Leu Gly Thr Val Ala Ala
    1285                1290                1295

 ttg gtg gcc ctc gtg ctc aac gtg ttc tat cct ctg gta tcc cag agt     4293
 Leu Val Ala Leu Val Leu Asn Val Phe Tyr Pro Leu Val Ser Gln Ser
1300                1305                1310                1315

 cgc tgg aga tgagctcgcc tgcaggcagc tgctgtgagc tggcctacct gcctgc      4348
 Arg Trp Arg 






      <210> 151
      <211> 2641
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (93)..(2132)

      <400> 151
 tcgtcgcggc cggctgagtc ctctccagcc gcgagaggcg tttctccatc cgcggctcgc     60

 gcgctcgctc tgagcccccg cgcccaggtg gg  atg gaa gaa gcc tgt cag gtg     113
                                      Met Glu Glu Ala Cys Gln Val
                                        1               5

 cag aca act aag cga ggg gat cct cat gag tta aga aac ata ttt cta      161
 Gln Thr Thr Lys Arg Gly Asp Pro His Glu Leu Arg Asn Ile Phe Leu
          10                  15                  20

 cag tat gcc agt act gag gtt gat gga gag cgt tac atg acc cca gaa      209
 Gln Tyr Ala Ser Thr Glu Val Asp Gly Glu Arg Tyr Met Thr Pro Glu
      25                  30                  35

 gac ttt gtt cag cgc tat ctt gga ctg tat aat gat cca aat agt aac      257
 Asp Phe Val Gln Arg Tyr Leu Gly Leu Tyr Asn Asp Pro Asn Ser Asn
  40                  45                  50                  55

 cca aag atc gtg cag ctc ttg gca gga gta gct gat caa acc aag gat      305
 Pro Lys Ile Val Gln Leu Leu Ala Gly Val Ala Asp Gln Thr Lys Asp
                  60                  65                  70

 ggg ttg atc tcc tat caa gag ttt ttg gca ttt gaa tct gtt tta tgt      353
 Gly Leu Ile Ser Tyr Gln Glu Phe Leu Ala Phe Glu Ser Val Leu Cys
              75                  80                  85

 gct cca gat tcc atg ttc ata gtg gct ttc cag ttg ttt gac aag agt      401
 Ala Pro Asp Ser Met Phe Ile Val Ala Phe Gln Leu Phe Asp Lys Ser
          90                  95                 100

 gga aat gga gag gtg aca ttt gaa aat gtc aaa gaa att ttt gga cag      449
 Gly Asn Gly Glu Val Thr Phe Glu Asn Val Lys Glu Ile Phe Gly Gln
     105                 110                 115

 act att att cat cat cat atc cct ttt aac tgg gat tgt gaa ttt atc      497
 Thr Ile Ile His His His Ile Pro Phe Asn Trp Asp Cys Glu Phe Ile
 120                 125                 130                 135

 cga ctg cat ttt ggg cat aac cgg aag aag cat ctt aac tac aca gaa      545
 Arg Leu His Phe Gly His Asn Arg Lys Lys His Leu Asn Tyr Thr Glu
                 140                 145                 150

 ttc acg cag ttt ctc cag gag ctg caa ttg gaa cat gca aga caa gcc      593
 Phe Thr Gln Phe Leu Gln Glu Leu Gln Leu Glu His Ala Arg Gln Ala
             155                 160                 165

 ttt gca ctc aaa gac aaa agc aaa agt ggc atg att tct ggt ctg gat      641
 Phe Ala Leu Lys Asp Lys Ser Lys Ser Gly Met Ile Ser Gly Leu Asp
         170                 175                 180

 ttc agt gac atc atg gtt acc att aga tct cac atg ctt act cct ttt      689
 Phe Ser Asp Ile Met Val Thr Ile Arg Ser His Met Leu Thr Pro Phe
     185                 190                 195

 gtg gag gag aac tta gtt tca gca gct gga gga agt atc tca cac cag      737
 Val Glu Glu Asn Leu Val Ser Ala Ala Gly Gly Ser Ile Ser His Gln
 200                 205                 210                 215

 gtt agc ttc tcc tac ttc aat gca ttt aac tcg tta ctg aat aac atg      785
 Val Ser Phe Ser Tyr Phe Asn Ala Phe Asn Ser Leu Leu Asn Asn Met
                 220                 225                 230

 gag ctt gtt cgt aag ata tat agc act cta gct ggc aca agg aaa gat      833
 Glu Leu Val Arg Lys Ile Tyr Ser Thr Leu Ala Gly Thr Arg Lys Asp
             235                 240                 245

 gtt gaa gtc aca aag gag gaa ttt gcc cag agt gcc ata cgc tat gga      881
 Val Glu Val Thr Lys Glu Glu Phe Ala Gln Ser Ala Ile Arg Tyr Gly
         250                 255                 260

 caa gtc aca cca cta gaa att gat att cta tat cag ctt gca gac tta      929
 Gln Val Thr Pro Leu Glu Ile Asp Ile Leu Tyr Gln Leu Ala Asp Leu
     265                 270                 275

 tat aat gct tca ggg cgc ttg act ttg gca gat att gag aga ata gcc      977
 Tyr Asn Ala Ser Gly Arg Leu Thr Leu Ala Asp Ile Glu Arg Ile Ala
 280                 285                 290                 295

 cca ttg gct gag ggg gcc tta cct tac aac ctg gca gaa ctt cag aga     1025
 Pro Leu Ala Glu Gly Ala Leu Pro Tyr Asn Leu Ala Glu Leu Gln Arg
                 300                 305                 310

 cag cag tct cct ggg tta ggc agg cct atc tgg ctc cag att gcc gag     1073
 Gln Gln Ser Pro Gly Leu Gly Arg Pro Ile Trp Leu Gln Ile Ala Glu
             315                 320                 325

 tct gct tac aga ttc act ctg ggc tca gtt gct gga gct gtg gga gcc     1121
 Ser Ala Tyr Arg Phe Thr Leu Gly Ser Val Ala Gly Ala Val Gly Ala
         330                 335                 340

 act gca gtg tat cct ata gat ctg gtg aag acc cga atg caa aac cag     1169
 Thr Ala Val Tyr Pro Ile Asp Leu Val Lys Thr Arg Met Gln Asn Gln
     345                 350                 355

 cgt ggc tct ggc tct gtt gtt ggg gag cta atg tac aaa aac agc ttt     1217
 Arg Gly Ser Gly Ser Val Val Gly Glu Leu Met Tyr Lys Asn Ser Phe
 360                 365                 370                 375

 gac tgt ttt aag aaa gtc ttg cgt tat gag ggc ttc ttt gga ctc tac     1265
 Asp Cys Phe Lys Lys Val Leu Arg Tyr Glu Gly Phe Phe Gly Leu Tyr
                 380                 385                 390

 agg ggt ctg ata cca caa ctt ata ggg gtt gct cca gaa aag gcc att     1313
 Arg Gly Leu Ile Pro Gln Leu Ile Gly Val Ala Pro Glu Lys Ala Ile
             395                 400                 405

 aaa ctg act gtt aat gat ttt gtt cgg gac aaa ttt acc aga aga gat     1361
 Lys Leu Thr Val Asn Asp Phe Val Arg Asp Lys Phe Thr Arg Arg Asp
         410                 415                 420

 ggc tct gtt cca ctt cca gca gaa gtt ctt gct gga ggc tgt gct gga     1409
 Gly Ser Val Pro Leu Pro Ala Glu Val Leu Ala Gly Gly Cys Ala Gly
     425                 430                 435

 ggc tct cag gtc att ttt acc aac cca ttg gag ata gtg aag att cgt     1457
 Gly Ser Gln Val Ile Phe Thr Asn Pro Leu Glu Ile Val Lys Ile Arg
 440                 445                 450                 455

 ctg caa gta gct gga gag atc acc acg gga ccc aga gtc agc gcc ctg     1505
 Leu Gln Val Ala Gly Glu Ile Thr Thr Gly Pro Arg Val Ser Ala Leu
                 460                 465                 470

 aat gtg ctc cgg gac ttg gga att ttt ggt ctg tat aag ggt gcc aaa     1553
 Asn Val Leu Arg Asp Leu Gly Ile Phe Gly Leu Tyr Lys Gly Ala Lys
             475                 480                 485

 gcg tgt ttc ctc cga gac att ccc ttc tct gca atc tat ttt cct gtt     1601
 Ala Cys Phe Leu Arg Asp Ile Pro Phe Ser Ala Ile Tyr Phe Pro Val
         490                 495                 500

 tat gct cat tgc aaa cta ctt ctg gct gat gaa aat gga cac gtg gga     1649
 Tyr Ala His Cys Lys Leu Leu Leu Ala Asp Glu Asn Gly His Val Gly
     505                 510                 515

 ggt tta aat ctt ctt gca gct gga gcc atg gca ggt gtc cca gct gca     1697
 Gly Leu Asn Leu Leu Ala Ala Gly Ala Met Ala Gly Val Pro Ala Ala
 520                 525                 530                 535

 tct ctg gtg acc cct gct gat gtc atc aag aca aga ctg cag gtg gct     1745
 Ser Leu Val Thr Pro Ala Asp Val Ile Lys Thr Arg Leu Gln Val Ala
                 540                 545                 550

 gcc cgc gct ggc cag acg aca tac agt ggt gtc atc gac tgt ttc agg     1793
 Ala Arg Ala Gly Gln Thr Thr Tyr Ser Gly Val Ile Asp Cys Phe Arg
             555                 560                 565

 aag att ctc cgg gaa gaa ggg ccc tca gca ttt tgg aaa ggg act gca     1841
 Lys Ile Leu Arg Glu Glu Gly Pro Ser Ala Phe Trp Lys Gly Thr Ala
         570                 575                 580

 gct cga gtg ttt cga tcc tct ccc cag ttt ggt gtt acc ttg gtc act     1889
 Ala Arg Val Phe Arg Ser Ser Pro Gln Phe Gly Val Thr Leu Val Thr
     585                 590                 595

 tat gaa ctt ctc cag cgg tgg ttt tac att gat ttt gga ggc ctc aaa     1937
 Tyr Glu Leu Leu Gln Arg Trp Phe Tyr Ile Asp Phe Gly Gly Leu Lys
 600                 605                 610                 615

 ccc gct ggt tca gaa cca aca cct aag tca cgc att gca gac ctt cct     1985
 Pro Ala Gly Ser Glu Pro Thr Pro Lys Ser Arg Ile Ala Asp Leu Pro
                 620                 625                 630

 cct gcc aac cct gat cac atc ggt gga tac aga ctc gcc aca gcc acg     2033
 Pro Ala Asn Pro Asp His Ile Gly Gly Tyr Arg Leu Ala Thr Ala Thr
             635                 640                 645

 ttt gca ggc atc gaa aac aaa ttt ggc ctt tat ctc ccg aaa ttt aag     2081
 Phe Ala Gly Ile Glu Asn Lys Phe Gly Leu Tyr Leu Pro Lys Phe Lys
         650                 655                 660

 tct cct agt gtt gct gtg gtt cag cca aag gca gca gtg gca gcc act     2129
 Ser Pro Ser Val Ala Val Val Gln Pro Lys Ala Ala Val Ala Ala Thr
     665                 670                 675

 cag tgat gagacaactg ttgagtgtgg caaaatggcg ccttgaagaa agagcctagg     2186
 Gln 
 680

 agagcagccc tgtaatgtat ccagtcagct gcatggtact gactgagctg aggagtcaaa   2246

 ctcttctttc tgtatgacat atacatatac ttgtttataa aataatcatt tgcccaggga   2306

 aaaaaccaca acgctgtttc aagctttagt cttatgtgtt gaaatgtttt tgtaagcctt   2366

 ggcatgaatt agtgttctag actctgcttt gcacagcttg cacttacagt gattgtacat   2426

 attgtacatc tttgtacaga gacatcttgg cacctcatcc caacaaatca catttgtaga   2486

 aatgtaatgc ggttctgagt ggcttgaaat gtacagaatg ttttgaaagt gttttattaa   2546

 gaatcacaca aaaataaatg tattaaaatt aaattcattc tcttattggt gacttatgga   2606

 aataaagcat caatattgga tgtaaaaaaa aaaaa                              2641




      <210> 152
      <211> 6833
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (19)..(2361)

      <220>
      <221> misc_feature
      <222> (1)...(6833)
      <223> n = a,t,c or g

      <400> 152
 cgcgaggcaa canatgac  atg ttg gcc ttc ctg tct ggg atg ccg gtg acc      51
                      Met Leu Ala Phe Leu Ser Gly Met Pro Val Thr
                        1               5                  10

 aga aac acc aag tac ctc gac ctc aag aat tca caa gag atg ctc cgc       99
 Arg Asn Thr Lys Tyr Leu Asp Leu Lys Asn Ser Gln Glu Met Leu Arg
              15                  20                  25

 tac aaa gag gtc tgc tac tac atg ctc ttt gcc ctg gct gcc tac ggg      147
 Tyr Lys Glu Val Cys Tyr Tyr Met Leu Phe Ala Leu Ala Ala Tyr Gly
          30                  35                  40

 tgg ccc atg tac ctg atg cgg aag ccc gcc tgc ggc ctc tgc caa ctg      195
 Trp Pro Met Tyr Leu Met Arg Lys Pro Ala Cys Gly Leu Cys Gln Leu
      45                  50                  55

 gct cgg tcc tgc tcg tgt tgc ctg tgt cct gcg agg ccg cgg ttc gcc      243
 Ala Arg Ser Cys Ser Cys Cys Leu Cys Pro Ala Arg Pro Arg Phe Ala
  60                  65                  70                  75

 cct gga gtc acc atc gag gaa gac aac tgc tgt ggc tgt aat gcc att      291
 Pro Gly Val Thr Ile Glu Glu Asp Asn Cys Cys Gly Cys Asn Ala Ile
                  80                  85                  90

 gcc atc cgg cgc cac ttc ctg gac gag aac atg act gcg gtg gac atc      339
 Ala Ile Arg Arg His Phe Leu Asp Glu Asn Met Thr Ala Val Asp Ile
              95                 100                 105

 gtc tat acc tcc tgc cat gat gcg gtc tat gaa acg ccc ttc tac gtg      387
 Val Tyr Thr Ser Cys His Asp Ala Val Tyr Glu Thr Pro Phe Tyr Val
         110                 115                 120

 gcg gtg gac cat gac aag aag aaa gtg gtg atc agt atc cgg ggg acc      435
 Ala Val Asp His Asp Lys Lys Lys Val Val Ile Ser Ile Arg Gly Thr
     125                 130                 135

 ctg tcc ccc aag gat gcc ctg act gac ctg acg ggt gat gct gag cgc      483
 Leu Ser Pro Lys Asp Ala Leu Thr Asp Leu Thr Gly Asp Ala Glu Arg
 140                 145                 150                 155

 ctc ccc gtg gag ggg cac cac ggc acc tgg ctg ggc cac aag ggt atg      531
 Leu Pro Val Glu Gly His His Gly Thr Trp Leu Gly His Lys Gly Met
                 160                 165                 170

 gtc ctc tca gct gag tac atc aag aag aaa ctg gag cag gag atg gtc      579
 Val Leu Ser Ala Glu Tyr Ile Lys Lys Lys Leu Glu Gln Glu Met Val
             175                 180                 185

 ctg tcc cag gcc ttt ggg cga gac ctg ggc cgc gga acc aaa cac tac      627
 Leu Ser Gln Ala Phe Gly Arg Asp Leu Gly Arg Gly Thr Lys His Tyr
         190                 195                 200

 ggc ctg att gtg gtg ggc cac tcc ctg ggc gcg ggc act gct gcc atc      675
 Gly Leu Ile Val Val Gly His Ser Leu Gly Ala Gly Thr Ala Ala Ile
     205                 210                 215

 ctc tcc ttc ctt ctg cgc cca cag tat ccg acc ctc aag tgc ttt gcc      723
 Leu Ser Phe Leu Leu Arg Pro Gln Tyr Pro Thr Leu Lys Cys Phe Ala
 220                 225                 230                 235

 tac tcc ccg cca ggg ggc ctg ctg agt gag gat gcg atg gag tat tcc      771
 Tyr Ser Pro Pro Gly Gly Leu Leu Ser Glu Asp Ala Met Glu Tyr Ser
                 240                 245                 250

 aag gag ttc gtg act gct gtg gtt ctg ggc aaa gac ctc gtc ccc agg      819
 Lys Glu Phe Val Thr Ala Val Val Leu Gly Lys Asp Leu Val Pro Arg
             255                 260                 265

 att ggc ctc tct cag ctg gaa ggc ttc cgc aga cag ctc ctg gat gtc      867
 Ile Gly Leu Ser Gln Leu Glu Gly Phe Arg Arg Gln Leu Leu Asp Val
         270                 275                 280

 ctg cag cga agc acc aag ccc aaa tgg cgg atc atc gtg ggg gcc acc      915
 Leu Gln Arg Ser Thr Lys Pro Lys Trp Arg Ile Ile Val Gly Ala Thr
     285                 290                 295

 aaa tgc atc ccc aag tcg gag ctg cct gag gag gta gag gtg acc acc      963
 Lys Cys Ile Pro Lys Ser Glu Leu Pro Glu Glu Val Glu Val Thr Thr
 300                 305                 310                 315

 ctg gcc agc acg cgg ctc tgg acc cac ccc agc gac cta act ata gcc     1011
 Leu Ala Ser Thr Arg Leu Trp Thr His Pro Ser Asp Leu Thr Ile Ala
                 320                 325                 330

 ctc tca gcc agc act cca ctc tac ccg ccc ggc cgc atc atc cac gtg     1059
 Leu Ser Ala Ser Thr Pro Leu Tyr Pro Pro Gly Arg Ile Ile His Val
             335                 340                 345

 gtc cac aac cac cct gca gag cag tgc tgc tgc tgt gag cag gag gag     1107
 Val His Asn His Pro Ala Glu Gln Cys Cys Cys Cys Glu Gln Glu Glu
         350                 355                 360

 ccc aca tac ttt gcc atc tgg ggc gac aac aag gcc ttc aat gag gtg     1155
 Pro Thr Tyr Phe Ala Ile Trp Gly Asp Asn Lys Ala Phe Asn Glu Val
     365                 370                 375

 atc atc tcg cca gcc atg ctg cat gag cac ctg ccc tat gtg gtc atg     1203
 Ile Ile Ser Pro Ala Met Leu His Glu His Leu Pro Tyr Val Val Met
 380                 385                 390                 395

 gag ggg ctc aac aag gtg ctg gag aac tac aac aag ggg aag acc gct     1251
 Glu Gly Leu Asn Lys Val Leu Glu Asn Tyr Asn Lys Gly Lys Thr Ala
                 400                 405                 410

 ctg ctc tct gca gcc aag gtc atg gtg agc cct acc gag gtg gac ctg     1299
 Leu Leu Ser Ala Ala Lys Val Met Val Ser Pro Thr Glu Val Asp Leu
             415                 420                 425

 act cct gag ctc atc ttc cag cag cag cca ctc ccc acg ggg ccg ccc     1347
 Thr Pro Glu Leu Ile Phe Gln Gln Gln Pro Leu Pro Thr Gly Pro Pro
         430                 435                 440

 atg ccc act ggc ctt gcc ctg gag ctg ccg act gca gac cac cgc aac     1395
 Met Pro Thr Gly Leu Ala Leu Glu Leu Pro Thr Ala Asp His Arg Asn
     445                 450                 455

 agc agc gtc agg agc aag tcc cag tct gag atg agc ctg gag ggc ttc     1443
 Ser Ser Val Arg Ser Lys Ser Gln Ser Glu Met Ser Leu Glu Gly Phe
 460                 465                 470                 475

 tcg gag ggg cgg ctg ctg tcg cca gtg gtt gcg gcg gcg gcc cgc cag     1491
 Ser Glu Gly Arg Leu Leu Ser Pro Val Val Ala Ala Ala Ala Arg Gln
                 480                 485                 490

 gac ccg gtg gag ctg ctg ctg ctg tct acc cag gag cgg ctg gca gcg     1539
 Asp Pro Val Glu Leu Leu Leu Leu Ser Thr Gln Glu Arg Leu Ala Ala
             495                 500                 505

 gag ctg cag gcc cgg cgg gca cca ctg gcc acc atg gag agc ctc tcg     1587
 Glu Leu Gln Ala Arg Arg Ala Pro Leu Ala Thr Met Glu Ser Leu Ser
         510                 515                 520

 gac act gag tcc ctg tac agc ttc gac tcg cgc cgc tcc tca ggc ttc     1635
 Asp Thr Glu Ser Leu Tyr Ser Phe Asp Ser Arg Arg Ser Ser Gly Phe
     525                 530                 535

 cgc agc atc cgg ggc tcc ccc agc ctc cac gct gtg ctg gag cgt gat     1683
 Arg Ser Ile Arg Gly Ser Pro Ser Leu His Ala Val Leu Glu Arg Asp
 540                 545                 550                 555

 gaa ggc cac ctc ttc tac att gac cct gcc atc ccc gag gaa aac cca     1731
 Glu Gly His Leu Phe Tyr Ile Asp Pro Ala Ile Pro Glu Glu Asn Pro
                 560                 565                 570

 tcc ctg agc tcg cgc act gag ctg ctg gcg gcc gac agc ctg tcc aag     1779
 Ser Leu Ser Ser Arg Thr Glu Leu Leu Ala Ala Asp Ser Leu Ser Lys
             575                 580                 585

 cac tca cag gac acg cag ccc ctg gag gcg gcc ctg ggc agt ggc ggc     1827
 His Ser Gln Asp Thr Gln Pro Leu Glu Ala Ala Leu Gly Ser Gly Gly
         590                 595                 600

 gtc act cct gag cgg ccc ccc agt gct gcg gcc aat gac gag gag gaa     1875
 Val Thr Pro Glu Arg Pro Pro Ser Ala Ala Ala Asn Asp Glu Glu Glu
     605                 610                 615

 gag gtt ggc ggt ggg ggt ggc ggg ccg gcc tcc cgc ggg gag ctg gcg     1923
 Glu Val Gly Gly Gly Gly Gly Gly Pro Ala Ser Arg Gly Glu Leu Ala
 620                 625                 630                 635

 ctg cac aat ggg cgc ctg ggg gac tcg ccc agt cct cag gtg ctg gaa     1971
 Leu His Asn Gly Arg Leu Gly Asp Ser Pro Ser Pro Gln Val Leu Glu
                 640                 645                 650

 ttc gcc gag ttc atc gac agc ctc ttc aac ctg gac agc aag agc agc     2019
 Phe Ala Glu Phe Ile Asp Ser Leu Phe Asn Leu Asp Ser Lys Ser Ser
             655                 660                 665

 tcc ttc caa gac ctc tac tgc atg gtg gtg ccc gag agc ccc acc agt     2067
 Ser Phe Gln Asp Leu Tyr Cys Met Val Val Pro Glu Ser Pro Thr Ser
         670                 675                 680

 gac tac gct gag ggc ccc aag tcc ccc agc cag caa gag atc ctg ctc     2115
 Asp Tyr Ala Glu Gly Pro Lys Ser Pro Ser Gln Gln Glu Ile Leu Leu
     685                 690                 695

 cgt gcc cag ttc gag ccc aac ctg gtg ccc aag ccc cca cgg ctc ttt     2163
 Arg Ala Gln Phe Glu Pro Asn Leu Val Pro Lys Pro Pro Arg Leu Phe
 700                 705                 710                 715

 gcc ggc tca gcc gac ccc tcc tcg ggc atc tca ctc tcg ccc tcc ttc     2211
 Ala Gly Ser Ala Asp Pro Ser Ser Gly Ile Ser Leu Ser Pro Ser Phe
                 720                 725                 730

 ccg ctc agc tcc tcg ggt gag ctc atg gac ctg acg ccc acg ggc ctc     2259
 Pro Leu Ser Ser Ser Gly Glu Leu Met Asp Leu Thr Pro Thr Gly Leu
             735                 740                 745

 agt agc cag gaa tgc ctg gcg gct gac aag atc cgg act tct acc ccc     2307
 Ser Ser Gln Glu Cys Leu Ala Ala Asp Lys Ile Arg Thr Ser Thr Pro
         750                 755                 760

 act ggc cac gga gcc agc ccc gcc aag caa gat gag ctg gtc atc tca     2355
 Thr Gly His Gly Ala Ser Pro Ala Lys Gln Asp Glu Leu Val Ile Ser
     765                 770                 775

 gca cgc tagcacccca gttgcgtggc cagccgggcc caggcaggag caggtggccc      2411
 Ala Arg 
 780

 tgtgggcacc tggtgcctgc cccctgccgg gcagctttaa ggacagaccc ccaggggcag   2471

 tttagcctca ggcacaggca tcgctgctga gctgggggtc cgcatcccta cctcagctta   2531

 ggacccccag agccaaggtg gctgggatct ggccccacag atggggaaag atggggaagg   2591

 gtgtggagtg gggaggagcc tgggcagcct gctgggtggg ccacactcag cctgactgcc   2651

 ctccatgggg gcattctggc accccctgct ccaggacagg ccatgggcaa gctgcctccc   2711

 atcactgcct gctggctgct ctcccagggg ccaggtggag agcagtgccc cccgacacat   2771

 gtattctcat ctgtggtcca ggccggcatc gtcctggcca ccccccagat ctggtgcctg   2831

 ctggccggcc ccctggggtg cccctgccga ggtggcctgc agtgctgtac atgtttacag   2891

 aagctgctgg gcttggctca ggatgtgttc tgggcttgca agccccccgc ccaatcatgt   2951

 gttcagtagc catcctctga gcagggccca aggcagccag gggcctggag gggccagagg   3011

 agggtggggt cagggccgcc ccttctctgc cttgtgcctc tcatgctgcc tcctctgccc   3071

 atgggtcctg ggcacccagg cctgccctgc ctgctggcta cttcctggct taccttctac   3131

 ccccaaggat cctcaccacc caaagggtgg tgggcactgc tgtgaccacc ccagctgcag   3191

 agtcagtgcc ctgggtggaa ggaaggcact gagagccccc ttcctctgag ggccccacct   3251

 caccccttgg tgtcaccccc accacgccta ggcagctctg ggccctggga tctggaacca   3311

 acacacccct gttcccctca gctttccctc ctcgctggcc tgggcaccct cctgggagca   3371

 ggccttcctc cctcccaccc ccaatgtcct gttggtagga ggtggggcca agagtggggt   3431

 atggtgggcc ttggctggag acctctgtcc actgcccagg gaggggcctg gggctgggag   3491

 cagtcccggt ttagcctgag gtccccatag ggcttcctcc cctgctgggt ttgggaagca   3551

 gttagggaga tagcgacccg gagtttcccc agaagcgggg tgggagggtg tgcatgctag   3611

 tgttggcgcg tatgcatgtg catgagtgtg caccgttcct aaggaagggg cctctggggc   3671

 tgcccaccct acctgccctg cctgcctgct gcccctccca gcctgccaag aaaacggtag   3731

 gggagcatga tggggccttt gaggcagggt cgcagggaca agctcagctt taggcaccat   3791

 ctgttcccat cgcgcctgct gctgtgaccc gttttggaaa actggtgtgt accgaggcgc   3851

 tgactgcacg gctgaccgcc tgctcgtgcc ttcattctgc agcggcatgg tccctcccat   3911

 tctggctcca cctgcagcct ccctgggtgg cctaggctcc cccgaccaag agacctccct   3971

 ctcatgatca ctggtacctg ggggcctgaa ttctggcccc cggctcccca cacagctggg   4031

 actggcctgg atggctgtcc tgggagcccc tgcccaccct gacagaggga gctgggcctc   4091

 ccctcatcct ctgtaactcc cgccttcacc agactcaagg acaccctggc cctgctgagg   4151

 catacagagc ttcagcccag cacagaagca agacaaaatc agtggctctt agagtttaga   4211

 aaacaagaca gactctcaga tgaaagatct gacaagcacc gtggccagtc acagggagag   4271

 acttgatgtc tggcctttta attcctcctc tgccagggtg ggtcctggga cctctaatgt   4331

 gggcatgtcg tccaccccag gacaagccat cagggacaga ccccccaccc ccaaggctgc   4391

 agccacacca tgtttcaggc ttggggctgg ggcaggcttg ggctcaatcc tgggcaccca   4451

 ggggcagccc acccctaacc tggctcctac ccaccttgcc cttgaaggat gggcctgctg   4511

 cacgtctccc tcctccaccc cataccacac tggggggtct gagccacccc cctcagcccc   4571

 gttcggctca gaccgacccc cactccatcc ccagacctgc agcacaagtg cgcgggcctg   4631

 tcctcccagg ggcctgggcg actccatatg caatcagtag cgagcagccg ggccccacag   4691

 accctcatgc actctcttac gtgccattct ccccagactt tttttgtact taatgtatga   4751

 aagatccaaa ctaatattgc tgtaaaaagg agagacaaat taatatagct tattctataa   4811

 atatatctgt atataaaggt ttctgtatat tgtatagagc tgtgtataaa ctggatgtag   4871

 aagcacgctg gctgcctcga atgtctttgc atcaggtggg gactgggtag aaatttgatg   4931

 tcgaggttgc agcagagcag ggggttggca tggggccggg ggccgggggg gcctctgcca   4991

 ctgttccctg gatggaacag aaagcctgct cctgctcggc tagtgccctg gcccggggcc   5051

 acactttgag ttgcagggag ggagtagaag acccttgaag ccccctgtga atgagggcag   5111

 ccacttgcgg agtcctgccc cactttgagc cctcctcttc ctctgcgaaa tggcctgatg   5171

 ccagtgctgt gtgggtccac aggaggccag gagagtccca cggtggggag gacagggctg   5231

 taccttctcc tgggctggcc tctacgccca ttacccatta accctcaggt gccagcatcc   5291

 ctctccccag tgctgccttc ggtctaccac ctcctcctgg ccctgctccc actcaaggga   5351

 cagtgatggg tgctgagagc tgattggaac tggagagggc accatttact gatcactgac   5411

 ctggcacttt acctccactg taaggcaggg atactgagtg tgctttatag atgaggcctc   5471

 tgaggacaga gggcaggcct tggggactag gtggagctgg ctacagggga cagccatgtc   5531

 tgctgggcta gggctgaaat ctcagcccct cactcactgt ggctcggtag agaagccagg   5591

 ggcacagatg aggactcatc tccattgatg ggccccccta ggtccttgta tgcaagtccc   5651

 ctgggctact ttcaccggcc cagccacctt cctgccccag cctctgcccc agcgctgctt   5711

 gggacccaac ttcattatgg agttggcaga tggcagcctc aactcttggc tgagcccttg   5771

 agtctgggac atttcagcca cctctttcct ccagtccaga gatgaaaatc cctggggaca   5831

 gttgctcctt tgctcagtga cctagtgtaa caggggagat ggcagggcct gagctccctt   5891

 agccaggtca gctgctacag ggttaacagg aggctccatt ccaccccttc caacttcaag   5951

 gctaccctag agattgaata atctatactc ttaattgatt ataatgcaat ggagttgggg   6011

 cgttagggac aaagtacgag tcttcccttc tacctccagc ccttgctgac caggacaggg   6071

 acaatgtgta gctcaacgga tggtggtgag aacttagatg atggtcagtt atgcagtatg   6131

 tgggatacgg aggaaagatc cgtgggtatg tggaggcttg tagagaagct ggttctgtgg   6191

 ctggtcccag gcgactcgta atgtaaatcc gtttctcaga atcgcgtggt gtaggcgggt   6251

 gtctactttg tccgcaggca ggcctgaccc cgggtggagg aggggcaggg tggagaataa   6311

 caattgtctt aagggagtct gcaagacagg agggggtggc agagaagaac ctcagctctg   6371

 aagaagctca ctgcccagcc cttcccacct tcctcttcac ggacctagca ccttcctggg   6431

 cctcagtttc tctcattgcc ttgggtgctg gagtatgtgg ggcctcctct cctatctcca   6491

 ggccttcagc cccggctgcc acggggtgtg ggtacctctt ggttgggtct cggggtagga   6551

 tgatgtaatg gttctgtgca ttcgccagcg agggcagctg gggtctgttc ctagctctcc   6611

 tgcttaccca cagtgcttct cttggccgta tcagggcacc gctgtgcctc cgctttctca   6671

 tcttgaagat tactggtccc cagggtaggt cagtgcccct aagcttaggg ggcttgttga   6731

 gcatgttctg tggttctgtg tgcaaggcct gaaccatgac agctctggcc cagcgtggcc   6791

 tggtcctggt ccctggcaca tccagtgggg cccgccccac ct                      6833




      <210> 153
      <211> 1666
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (143)..(562)

      <400> 153
 tttggcacta gttcagaatg gtgatgtgtc ggccccctct gccatactca gaacaccaga     60

 aagcacaaaa ccgggtcctg tttgtcagcc accagtgagt cagagccgct ccctgttttc    120

 ttctgtcccg tccaagccac ca atg tct ctg gag cct caa aat ggg acg tat     172
                          Met Ser Leu Glu Pro Gln Asn Gly Thr Tyr
                            1               5                  10

 gca gga cca gcg cca gca ttc cag cca ttt ttc ttc act gga gca ttt      220
 Ala Gly Pro Ala Pro Ala Phe Gln Pro Phe Phe Phe Thr Gly Ala Phe
                  15                  20                  25

 cca ttt aat atg caa gag ctg gta ctc aag gtg aga att cag aac cca      268
 Pro Phe Asn Met Gln Glu Leu Val Leu Lys Val Arg Ile Gln Asn Pro
              30                  35                  40

 tct ctt cga gaa aat gat ttc att gaa att gaa ctg gac cga cag gag      316
 Ser Leu Arg Glu Asn Asp Phe Ile Glu Ile Glu Leu Asp Arg Gln Glu
          45                  50                  55

 ctc acc tac caa gag ttg ctc aaa gtg tgt tgc tgt gag ctg ggt gtt      364
 Leu Thr Tyr Gln Glu Leu Leu Lys Val Cys Cys Cys Glu Leu Gly Val
      60                  65                  70

 aat cca gat caa gtg gag aag atc aga aag tta ccc aat act ctg tta      412
 Asn Pro Asp Gln Val Glu Lys Ile Arg Lys Leu Pro Asn Thr Leu Leu
  75                  80                  85                  90

 agg aag gac aag gat gtt gct cga ctc caa gat ttc cag gag ctg gaa      460
 Arg Lys Asp Lys Asp Val Ala Arg Leu Gln Asp Phe Gln Glu Leu Glu
                  95                 100                 105

 ctg gtt ctg atg ata agt gaa aat aat ttt ctg ttc aga aat gct gca      508
 Leu Val Leu Met Ile Ser Glu Asn Asn Phe Leu Phe Arg Asn Ala Ala
             110                 115                 120

 tcc aca ctg act gaa agg cct tgc tat aac agg aga gct tca aaa ctg      556
 Ser Thr Leu Thr Glu Arg Pro Cys Tyr Asn Arg Arg Ala Ser Lys Leu
         125                 130                 135

 act tac taatgcagca gggactttta tcactgagta ttatgacagt gtgcatcacc       612
 Thr Tyr 
     140

 tctgggccaa ggacaagcca ttgatctaaa tgcctcagat gcccgggagg gcctctggtg    672

 ccactgcata gtatatacta acatcattct gccaaggtag gaagcccctg acccccaagc    732

 agtggtgcca ctcttccaag cctcttggtg cacagtaaac ctattgcttg aagctttgaa    792

 cagctgagaa gtggtctgga gaggcagaag ctgaaggttc tatatccagt gtgttttatg    852

 tccagaatgt aagagagttg tctaagcagc agctgagaga gagcggagcc tatttctagc    912

 cactcctgtt gacagtgcac ctgaagggct gggatgcgtt tttcttggtg ttgcatgctc    972

 acaactctgc tgacattggg aacttatgag agaggaagac tcgggaaagc acagatactg   1032

 gacagatgga ttctggtgtg gggaaagcac agatactgga cagatggatt ctagtgtgac   1092

 ttgtgactgt gaggtttcct ataacatatt tataaatgtt actcaggtta aaagtattta   1152

 agaatacagt taactaattg taaatatgct gttaaccaaa agagctttcc ctccctcact   1212

 ttttcctttg taaacactca tgactgcttc tctgtctcga gtcatctctg cattaactcc   1272

 ccttcgtggt cactagaggg ctctctgatg ccttctaaaa gaacaactgc ttttttacaa   1332

 tgccccccac ccccaccccg cccatagaga cagggtctca ctatgtggcc caggctggtc   1392

 tcaaacttct ggccttaagt gatgctcctg tccttggcct cccaaagtgc tgggattaca   1452

 ggtgtgagcc actgcaccca gcccactttt tttttactct gaagtgattc cagtcatatg   1512

 tgtgtgtaac tgcatcctat gagaagagca caaatattgc tgttccatgt tctccacttt   1572

 cattttccac tacaaatgaa aagcaatttt tgagactgaa tctgttgcta ttttaaaggt   1632

 tattgtggga aactgagcta aaggagttag catc                               1666




      <210> 154
      <211> 1588
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (453)..(1406)

      <400> 154
 cgtccgctct gtctcaaata ataataataa taataataat aataataata ataataataa     60

 tgtaggggac ttgatgaagg gaaaggatca gatagattct gaaaagaagt acagaacctg    120

 ctaaggccat catacctatt gatcggaagt cagtccatca gatttgctct ggaccggtgg    180

 tactgagtct aatcactgcg tgtaagaaga tagtaggaaa cattctggat gctaggtgcc    240

 agtaatattg atctaaagct taaggactat ggaatggatc tcattgaagt ttcaggcaat    300

 ggatgtgggg tagaagaaga aaacttcgaa ggcttaatct ctttcagctc tgaaacatca    360

 cacatctaag attcaagagt ttgccgacct aactcgggtt gaaacttttg gctttcgggg    420

 gaaagctctg agctcacttt gtgcactgag tg  atg tca cca ttt cta cct gcc     473
                                      Met Ser Pro Phe Leu Pro Ala
                                        1               5

 acg tat cgg cga agg ttg gga ctc gac tgg tgt ttg atc acg atg gga      521
 Thr Tyr Arg Arg Arg Leu Gly Leu Asp Trp Cys Leu Ile Thr Met Gly
          10                  15                  20

 aaa tca tcc aga aaa ccc cct acc ccc acc cca gag gga ccc aca gtc      569
 Lys Ser Ser Arg Lys Pro Pro Thr Pro Thr Pro Glu Gly Pro Thr Val
      25                  30                  35

 agc gtg aag cag tta ttt tct acg cta cct gtg cgc cat aag gaa ttt      617
 Ser Val Lys Gln Leu Phe Ser Thr Leu Pro Val Arg His Lys Glu Phe
  40                  45                  50                  55

 caa agg aat att aag aag aaa cgt gcc tgc ttc ccc ttc gcc ttc tgc      665
 Gln Arg Asn Ile Lys Lys Lys Arg Ala Cys Phe Pro Phe Ala Phe Cys
                  60                  65                  70

 cgt gat tgt cag ttt ctt gag ggc tcc cca gcc atg ctt cct gta cag      713
 Arg Asp Cys Gln Phe Leu Glu Gly Ser Pro Ala Met Leu Pro Val Gln
              75                  80                  85

 cct gca aaa ctt aca gaa cct gct aag gcc atc aaa cct att gat cgg      761
 Pro Ala Lys Leu Thr Glu Pro Ala Lys Ala Ile Lys Pro Ile Asp Arg
          90                  95                 100

 aag tca gtc cat cag att tgc tct ggg ccg gtg gta ctg agt cta agc      809
 Lys Ser Val His Gln Ile Cys Ser Gly Pro Val Val Leu Ser Leu Ser
     105                 110                 115

 act gcg gtg aag aag ata gta gga aac agt ctg gat gct ggt gcc act      857
 Thr Ala Val Lys Lys Ile Val Gly Asn Ser Leu Asp Ala Gly Ala Thr
 120                 125                 130                 135

 aat att gat cta aag ctt aag gac tat gga atg gat ctc att gaa gtt      905
 Asn Ile Asp Leu Lys Leu Lys Asp Tyr Gly Met Asp Leu Ile Glu Val
                 140                 145                 150

 tca ggc aat gga tgt ggg gta gaa gaa gaa aac ttc gaa ggc tta tct      953
 Ser Gly Asn Gly Cys Gly Val Glu Glu Glu Asn Phe Glu Gly Leu Ser
             155                 160                 165

 ctt tca gct ctg aaa cat cac aca tct aag att cga gag ttt gcc gac     1001
 Leu Ser Ala Leu Lys His His Thr Ser Lys Ile Arg Glu Phe Ala Asp
         170                 175                 180

 cta act cgg gtt gaa act ttt ggc ttt cag ggg aaa gct ctg agc tca     1049
 Leu Thr Arg Val Glu Thr Phe Gly Phe Gln Gly Lys Ala Leu Ser Ser
     185                 190                 195

 ctt tgt gca ctg agt gat gtc acc att tct acc tgc cac gta tcg gcg     1097
 Leu Cys Ala Leu Ser Asp Val Thr Ile Ser Thr Cys His Val Ser Ala
 200                 205                 210                 215

 aag gtt ggg act cga ctg gtg ttt gat cac gat ggg aaa atc atc aag     1145
 Lys Val Gly Thr Arg Leu Val Phe Asp His Asp Gly Lys Ile Ile Lys
                 220                 225                 230

 aaa acc ccc tac ccc cac ccc aga ggg acc aca gtc agc gtg aag cag     1193
 Lys Thr Pro Tyr Pro His Pro Arg Gly Thr Thr Val Ser Val Lys Gln
             235                 240                 245

 tta ttt tct acg cta cct gtg cgc cat aag gaa ttt caa agg aat att     1241
 Leu Phe Ser Thr Leu Pro Val Arg His Lys Glu Phe Gln Arg Asn Ile
         250                 255                 260

 aag aag aaa cgt gcc tgc ttc ccc ttc gcc ttc tgc cgt gat tgt cag     1289
 Lys Lys Lys Arg Ala Cys Phe Pro Phe Ala Phe Cys Arg Asp Cys Gln
     265                 270                 275

 ttt ctt gag ggc tcc cca gcc atg ctt cct gta cag cct gca aaa ctg     1337
 Phe Leu Glu Gly Ser Pro Ala Met Leu Pro Val Gln Pro Ala Lys Leu
 280                 285                 290                 295

 act gta act gga gag cta cgg gca tgc aga agt tgg aag acg agg gaa     1385
 Thr Val Thr Gly Glu Leu Arg Ala Cys Arg Ser Trp Lys Thr Arg Glu
                 300                 305                 310

 ggc atc aca gag gct gtg ggg tg aaccgacttc aaggaatggg tccttccctt     1438
 Gly Ile Thr Glu Ala Val Gly 
             315

 cagaaccaca tgtgtgcggg acacccagac agaaaacaca aatgcaaagt caagtggagg   1498

 gcatttggaa ggagcagtga agccaagcca ggaaacacca agatggcgag ccagtgtggt   1558

 tgtagagatt gcagagaggg acaagataag                                    1588




      <210> 155
      <211> 3639
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (360)..(3518)

      <400> 155
 ggctgccagg gtatttcggg aagggggcgt gaggaggcgg cggcggcagc ggcgggtagg     60

 gcaggcagca gagggaagga gaaagaaagg aaggaagagg gcggggagtc ctcagaggag    120

 gaggcgggac cggccgggca cctcacctct cggcggcggc ggcggcggcg gcggcggcgg    180

 cgggcggccg gggaggcggc gccgccccct gcccgcggtc ttctcagcgc agtcgggcgc    240

 ggacccgctg gtcccgggca gcggccaagg ctactggggc gggagcagtg ggccggtcgg    300

 cggcggcagc ggcagcggcg gaggaggagg aggctggagt gggcgcggag gcgaccgcc     359                                                                 
 atg gcg ttc ctc aaa ctc cgt gac cag cca tca ctg gtg caa gct ata      407
 Met Ala Phe Leu Lys Leu Arg Asp Gln Pro Ser Leu Val Gln Ala Ile
   1               5                  10                  15

 ttt aac gga gat cct gat gaa gtt cga gca cta ata ttt aag aaa gaa      455
 Phe Asn Gly Asp Pro Asp Glu Val Arg Ala Leu Ile Phe Lys Lys Glu
              20                  25                  30

 gat gtt aac ttt cag gac aat gaa aag cga acc cca ttg cac gcc gca      503
 Asp Val Asn Phe Gln Asp Asn Glu Lys Arg Thr Pro Leu His Ala Ala
          35                  40                  45

 gct tac ctt gga gat gca gaa atc att gaa ctt ctt att tta tct gga      551
 Ala Tyr Leu Gly Asp Ala Glu Ile Ile Glu Leu Leu Ile Leu Ser Gly
      50                  55                  60

 gct aga gtt aat gcc aaa gac agc aaa tgg ttg aca cct tta cac aga      599
 Ala Arg Val Asn Ala Lys Asp Ser Lys Trp Leu Thr Pro Leu His Arg
  65                  70                  75                  80

 gca gtt gca tct tgt agt gag gaa gca gtt cag gta ctt ttg aag cat      647
 Ala Val Ala Ser Cys Ser Glu Glu Ala Val Gln Val Leu Leu Lys His
                  85                  90                  95

 tct gca gat gtt aat gct cga gac aaa aat tgg caa acc cct tta cat      695
 Ser Ala Asp Val Asn Ala Arg Asp Lys Asn Trp Gln Thr Pro Leu His
             100                 105                 110

 ata gct gct gct aat aaa gct gta aag tgt gct gaa gct ttg gta cct      743
 Ile Ala Ala Ala Asn Lys Ala Val Lys Cys Ala Glu Ala Leu Val Pro
         115                 120                 125

 ctt ctg agt aat gta aac gta tct gat cga gca ggg agg act gca tta      791
 Leu Leu Ser Asn Val Asn Val Ser Asp Arg Ala Gly Arg Thr Ala Leu
     130                 135                 140

 cat cat gca gct ttc agt gga cat ggt gag atg gtc aaa cta ctc ttg      839
 His His Ala Ala Phe Ser Gly His Gly Glu Met Val Lys Leu Leu Leu
 145                 150                 155                 160

 tct aga ggt gcc aat att aat gct ttt gac aag aaa gat agg cgt gct      887
 Ser Arg Gly Ala Asn Ile Asn Ala Phe Asp Lys Lys Asp Arg Arg Ala
                 165                 170                 175

 atc cat tgg gca gca tat atg ggt cac att gaa gta gtg aaa ttg ctt      935
 Ile His Trp Ala Ala Tyr Met Gly His Ile Glu Val Val Lys Leu Leu
             180                 185                 190

 gtg tcg cat gga gct gaa gtg aca tgc aag gat aaa aag tct tat aca      983
 Val Ser His Gly Ala Glu Val Thr Cys Lys Asp Lys Lys Ser Tyr Thr
         195                 200                 205

 cct ctt cat gca gca gcc tct agt gga atg atc agc gta gtc aag tac     1031
 Pro Leu His Ala Ala Ala Ser Ser Gly Met Ile Ser Val Val Lys Tyr
     210                 215                 220

 ctt cta gat ctt gga gtt gat atg aat gaa cca aat gcc tat gga aat     1079
 Leu Leu Asp Leu Gly Val Asp Met Asn Glu Pro Asn Ala Tyr Gly Asn
 225                 230                 235                 240

 aca cct ctt cat gta gcc tgc tat aat gga caa gat gtt gta gtg aat     1127
 Thr Pro Leu His Val Ala Cys Tyr Asn Gly Gln Asp Val Val Val Asn
                 245                 250                 255

 gaa ctt ata gac tgt ggt gct att gtg aat caa aag aat gaa aaa gga     1175
 Glu Leu Ile Asp Cys Gly Ala Ile Val Asn Gln Lys Asn Glu Lys Gly
             260                 265                 270

 ttt act cct ttg cac ttt gct gct gca tca aca cat gga gca ttg tgt     1223
 Phe Thr Pro Leu His Phe Ala Ala Ala Ser Thr His Gly Ala Leu Cys
         275                 280                 285

 tta gag ctt cta gtt ggc aat ggg gcc gat gtc aat atg aag agt aaa     1271
 Leu Glu Leu Leu Val Gly Asn Gly Ala Asp Val Asn Met Lys Ser Lys
     290                 295                 300

 gat ggg aaa acc cca cta cac atg act gct ctc cac ggt aga ttc tcc     1319
 Asp Gly Lys Thr Pro Leu His Met Thr Ala Leu His Gly Arg Phe Ser
 305                 310                 315                 320

 cga tca caa acc att atc cag agt gga gct gta atc gac tgt gag gat     1367
 Arg Ser Gln Thr Ile Ile Gln Ser Gly Ala Val Ile Asp Cys Glu Asp
                 325                 330                 335

 aag aat gga aat acc cct ttg cac ata gca gca cgg tat ggc cat gag     1415
 Lys Asn Gly Asn Thr Pro Leu His Ile Ala Ala Arg Tyr Gly His Glu
             340                 345                 350

 ctg ctg atc aac act ctt att aca agt ggt gct gac act gca aag cgt     1463
 Leu Leu Ile Asn Thr Leu Ile Thr Ser Gly Ala Asp Thr Ala Lys Arg
         355                 360                 365

 ggc ata cat gga atg ttc ccc ctc cat ttg gca gcc tta agc ggc ttt     1511
 Gly Ile His Gly Met Phe Pro Leu His Leu Ala Ala Leu Ser Gly Phe
     370                 375                 380

 tca gat tgc tgc aga aaa ctt ctt tct tca gga ttt gat ata gat acc     1559
 Ser Asp Cys Cys Arg Lys Leu Leu Ser Ser Gly Phe Asp Ile Asp Thr
 385                 390                 395                 400

 cca gat gat ttt ggc agg act tgt cta cat gca gct gca gct gga ggg     1607
 Pro Asp Asp Phe Gly Arg Thr Cys Leu His Ala Ala Ala Ala Gly Gly
                 405                 410                 415

 aat ttg gag tgc cta aac ctt ctg ctg aat act ggt gca gac ttt aat     1655
 Asn Leu Glu Cys Leu Asn Leu Leu Leu Asn Thr Gly Ala Asp Phe Asn
             420                 425                 430

 aaa aag gac aaa ttt ggg aga tct cca ctg cac tac gct gct gcc aac     1703
 Lys Lys Asp Lys Phe Gly Arg Ser Pro Leu His Tyr Ala Ala Ala Asn
         435                 440                 445

 tgc aat tac cag tgc ctg ttt gct ctt gtg gga tca gga gca agt gtg     1751
 Cys Asn Tyr Gln Cys Leu Phe Ala Leu Val Gly Ser Gly Ala Ser Val
     450                 455                 460

 aat gac ctt gat gaa aga ggc tgc aca ccc ctg cac tat gca gct aca     1799
 Asn Asp Leu Asp Glu Arg Gly Cys Thr Pro Leu His Tyr Ala Ala Thr
 465                 470                 475                 480

 tca gac aca gat ggc aag tgc ctg gaa tac tta tta aga aac gat gca     1847
 Ser Asp Thr Asp Gly Lys Cys Leu Glu Tyr Leu Leu Arg Asn Asp Ala
                 485                 490                 495

 aat cca ggg atc cgt gat aag caa gga tac aac gca gtt cat tat tca     1895
 Asn Pro Gly Ile Arg Asp Lys Gln Gly Tyr Asn Ala Val His Tyr Ser
             500                 505                 510

 gct gct tat ggt cac cgt cta tgt ctt cag ctg att gca agt gaa act     1943
 Ala Ala Tyr Gly His Arg Leu Cys Leu Gln Leu Ile Ala Ser Glu Thr
         515                 520                 525

 cct cta gat gtt tta atg gaa acc tca gga aca gac atg ctg agt gat     1991
 Pro Leu Asp Val Leu Met Glu Thr Ser Gly Thr Asp Met Leu Ser Asp
     530                 535                 540

 tca gat aat aga gca aca ata agc cct tta cac ttg gct gcc tat cat     2039
 Ser Asp Asn Arg Ala Thr Ile Ser Pro Leu His Leu Ala Ala Tyr His
 545                 550                 555                 560

 ggt cac cat caa gca ctg gaa gtg ttg gta cag tct ttg tta gat ctt     2087
 Gly His His Gln Ala Leu Glu Val Leu Val Gln Ser Leu Leu Asp Leu
                 565                 570                 575

 gat gtc aga aat agt agt gga aga aca ccc cta gat ctt gca gct ttt     2135
 Asp Val Arg Asn Ser Ser Gly Arg Thr Pro Leu Asp Leu Ala Ala Phe
             580                 585                 590

 aag ggc cat gtt gaa tgt gtg gat gta ctc att aat cag gga gcc tca     2183
 Lys Gly His Val Glu Cys Val Asp Val Leu Ile Asn Gln Gly Ala Ser
         595                 600                 605

 atc tta gta aaa gat tac att ttg aag agg aca cct att cat gca gca     2231
 Ile Leu Val Lys Asp Tyr Ile Leu Lys Arg Thr Pro Ile His Ala Ala
     610                 615                 620

 gca aca aat ggt cat tca gaa tgc tta cgg cta tta ata gga aat gca     2279
 Ala Thr Asn Gly His Ser Glu Cys Leu Arg Leu Leu Ile Gly Asn Ala
 625                 630                 635                 640

 gaa cca cag aat gca gtg gat att caa gat gga aat gga cag acg cct     2327
 Glu Pro Gln Asn Ala Val Asp Ile Gln Asp Gly Asn Gly Gln Thr Pro
                 645                 650                 655

 ctg atg cta tct gtt ctc aac ggg cac aca gac tgt gtt tac tca ttg     2375
 Leu Met Leu Ser Val Leu Asn Gly His Thr Asp Cys Val Tyr Ser Leu
             660                 665                 670

 ctg aac aaa gga gca aat gta gat gcc aaa gat aag tgg gga agg aca     2423
 Leu Asn Lys Gly Ala Asn Val Asp Ala Lys Asp Lys Trp Gly Arg Thr
         675                 680                 685

 gcg ttg cat aga ggg gca gtt aca ggc cat gaa gaa tgt gta gat gca     2471
 Ala Leu His Arg Gly Ala Val Thr Gly His Glu Glu Cys Val Asp Ala
     690                 695                 700

 tta ctt caa cat ggt gct aag tgc tta ctt cgg gat agc agg ggc cgg     2519
 Leu Leu Gln His Gly Ala Lys Cys Leu Leu Arg Asp Ser Arg Gly Arg
 705                 710                 715                 720

 acg cct ata cac ctg tct gct gcc tgt gga cac att ggt gtt ctt gga     2567
 Thr Pro Ile His Leu Ser Ala Ala Cys Gly His Ile Gly Val Leu Gly
                 725                 730                 735

 gcc ctt ttg cag tca gca gca tct atg gat gca aat cca gcc aca gca     2615
 Ala Leu Leu Gln Ser Ala Ala Ser Met Asp Ala Asn Pro Ala Thr Ala
             740                 745                 750

 gac aat cat gga tat acg gca ctt cac tgg gct tgc tac aat ggt cac     2663
 Asp Asn His Gly Tyr Thr Ala Leu His Trp Ala Cys Tyr Asn Gly His
         755                 760                 765

 gag aca tgt gta gaa ctg ctt tta gaa cag gaa gtt ttc cag aaa acg     2711
 Glu Thr Cys Val Glu Leu Leu Leu Glu Gln Glu Val Phe Gln Lys Thr
     770                 775                 780

 gaa gga aat gct ttt agt cca ttg cat tgt gcc gtg ata aat gac aac     2759
 Glu Gly Asn Ala Phe Ser Pro Leu His Cys Ala Val Ile Asn Asp Asn
 785                 790                 795                 800

 gaa ggt gct gct gag atg tta att gat aca tta ggt gcc agc att gtg     2807
 Glu Gly Ala Ala Glu Met Leu Ile Asp Thr Leu Gly Ala Ser Ile Val
                 805                 810                 815

 aac gcc aca gat tca aaa gga aga act cct ctc cat gca gcc gcc ttc     2855
 Asn Ala Thr Asp Ser Lys Gly Arg Thr Pro Leu His Ala Ala Ala Phe
             820                 825                 830

 aca gac cat gta gag tgt tta cag ctg ctg ctc agc cat aat gct caa     2903
 Thr Asp His Val Glu Cys Leu Gln Leu Leu Leu Ser His Asn Ala Gln
         835                 840                 845

 gtc aat tct gtg gac tct aca ggg aaa aca cct ctt atg atg gct gca     2951
 Val Asn Ser Val Asp Ser Thr Gly Lys Thr Pro Leu Met Met Ala Ala
     850                 855                 860

 gaa aat gga caa aca aat aca gtt gag atg ctg gtt agc agt gct agt     2999
 Glu Asn Gly Gln Thr Asn Thr Val Glu Met Leu Val Ser Ser Ala Ser
 865                 870                 875                 880

 gca gaa ctg act tta caa gat aac agt aaa aat act gcc ctc cat ttg     3047
 Ala Glu Leu Thr Leu Gln Asp Asn Ser Lys Asn Thr Ala Leu His Leu
                 885                 890                 895

 gct tgt agc aag ggt cat gaa act agt gcc ttg tta ata ctg gaa aag     3095
 Ala Cys Ser Lys Gly His Glu Thr Ser Ala Leu Leu Ile Leu Glu Lys
             900                 905                 910

 ata aca gat aga aac ctc atc aat gca acc aac gca gcc ttg caa aca     3143
 Ile Thr Asp Arg Asn Leu Ile Asn Ala Thr Asn Ala Ala Leu Gln Thr
         915                 920                 925

 cct ctg cat gtt gct gcc cga aat ggg cta aca atg gtg gtt cag gaa     3191
 Pro Leu His Val Ala Ala Arg Asn Gly Leu Thr Met Val Val Gln Glu
     930                 935                 940

 ctt ttg gga aaa gga gca agt gtg ctt gca gta gat gaa aat ggc tat     3239
 Leu Leu Gly Lys Gly Ala Ser Val Leu Ala Val Asp Glu Asn Gly Tyr
 945                 950                 955                 960

 acc cca gct ttg gcc tgt gct ccc aat aag gat gtg gct gat tgc ctg     3287
 Thr Pro Ala Leu Ala Cys Ala Pro Asn Lys Asp Val Ala Asp Cys Leu
                 965                 970                 975

 gct ctc att ttg gcc acc atg atg cct gtc tca tca agt agt cct tta     3335
 Ala Leu Ile Leu Ala Thr Met Met Pro Val Ser Ser Ser Ser Pro Leu
             980                 985                 990

 tca tcc tta aca ttc aat gcc att aac cgt tat acc aac acc tca aaa     3383
 Ser Ser Leu Thr Phe Asn Ala Ile Asn Arg Tyr Thr Asn Thr Ser Lys
         995                1000                1005

 aca gtc agc ttt gaa gct ttg ccc atc atg agg aat gaa cct agc tcc     3431
 Thr Val Ser Phe Glu Ala Leu Pro Ile Met Arg Asn Glu Pro Ser Ser
    1010                1015                1020

 tat tgc agt ttc aat aac att gga ggg gaa cag gag tac tta tac act     3479
 Tyr Cys Ser Phe Asn Asn Ile Gly Gly Glu Gln Glu Tyr Leu Tyr Thr
1025                1030                1035                1040

 gac gtg gat gag ctc aac gac tcc gat tct gag acc tac tgagaggctg      3528
 Asp Val Asp Glu Leu Asn Asp Ser Asp Ser Glu Thr Tyr 
                1045                1050

 aggaggaggg agttctcaca gtaaagcttc aaactgtgct ttttcaggaa acaggcactt   3588

 tgatattcac gtagaaattc aacctaagag ggacagttcc gttgaagccg t            3639




      <210> 156
      <211> 2102
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (327)..(1685)

      <400> 156
 cggttgcact cttcctatag cccagagggc gagagggcct gtggcctggg ggaaggagga     60

 cgaggttctg cctggatccc agcagtagga cgctgtgcca tttgggaaca aaggaatagt    120

 ctgcctggaa tccctgcaga tcttggggcc ggaggccagt ccaacccttg gagcaggaag    180

 aaacgcaaag ttgtcaagaa ccaagtcgag ctgcctcaga gccggcccgc agtagctgca    240

 gactccgccc gcgacgtgtg cgcgcttctc tgggccagag cgagcctgtt ttgtgctcgg    300

 gttaagagat ttgtcccagc tatacc atg ggc cgc act cgg gaa gct ggc tgc     353
                              Met Gly Arg Thr Arg Glu Ala Gly Cys
                                1               5

 gtg gcc gct ggt gtg gtt atc ggg gct ggt gcc tgc tac tgt gta tac      401
 Val Ala Ala Gly Val Val Ile Gly Ala Gly Ala Cys Tyr Cys Val Tyr
  10                  15                  20                  25

 aga ctg gct tgg gga aga gac gag aac gag aaa atc tgg gac gaa gac      449
 Arg Leu Ala Trp Gly Arg Asp Glu Asn Glu Lys Ile Trp Asp Glu Asp
                  30                  35                  40

 gag gag tct acg gac acc tca gag att ggg gtt gag act gtg aaa gga      497
 Glu Glu Ser Thr Asp Thr Ser Glu Ile Gly Val Glu Thr Val Lys Gly
              45                  50                  55

 gct aaa act aac gct ggg gca ggg tct ggg gcc aaa ctt cag ggt gat      545
 Ala Lys Thr Asn Ala Gly Ala Gly Ser Gly Ala Lys Leu Gln Gly Asp
          60                  65                  70

 tca gag gtc aag cct gag gtg agt ttg gga ctc gag gat tgt ccg ggt      593
 Ser Glu Val Lys Pro Glu Val Ser Leu Gly Leu Glu Asp Cys Pro Gly
      75                  80                  85

 gta aaa gag aag gcc cat tca gga tcc cac agc gga ggt ggt cta gag      641
 Val Lys Glu Lys Ala His Ser Gly Ser His Ser Gly Gly Gly Leu Glu
  90                  95                 100                 105

 gcc aag gcc aag gcc ctt ttc aac acg ctg aag gaa cag gca agt gca      689
 Ala Lys Ala Lys Ala Leu Phe Asn Thr Leu Lys Glu Gln Ala Ser Ala
                 110                 115                 120

 aag gca ggc aaa ggg gct agg gtg ggt acc atc tct ggg aac agg acc      737
 Lys Ala Gly Lys Gly Ala Arg Val Gly Thr Ile Ser Gly Asn Arg Thr
             125                 130                 135

 ctt gca ccg agt tta ccc tgc cca gga ggc agg ggt gga ggc tgc cac      785
 Leu Ala Pro Ser Leu Pro Cys Pro Gly Gly Arg Gly Gly Gly Cys His
         140                 145                 150

 ccc acc agg agt gga tct agg gcc ggg ggc agg gca agt gga aaa tcc      833
 Pro Thr Arg Ser Gly Ser Arg Ala Gly Gly Arg Ala Ser Gly Lys Ser
     155                 160                 165

 aag gga aag gcc cga agt aag agc acc agg gct cca gct aca aca tgg      881
 Lys Gly Lys Ala Arg Ser Lys Ser Thr Arg Ala Pro Ala Thr Thr Trp
 170                 175                 180                 185

 cct gtc cgg aga ggc aag ttc aac ttt cct tat aaa att gat gat att      929
 Pro Val Arg Arg Gly Lys Phe Asn Phe Pro Tyr Lys Ile Asp Asp Ile
                 190                 195                 200

 ctg agt gct ccc gac ctc caa aag gtc ctc aac atc ctg gag cga aca      977
 Leu Ser Ala Pro Asp Leu Gln Lys Val Leu Asn Ile Leu Glu Arg Thr
             205                 210                 215

 aat gat cct ttt att caa gaa gta gcc ttg gtc act ctg ggt aac aat     1025
 Asn Asp Pro Phe Ile Gln Glu Val Ala Leu Val Thr Leu Gly Asn Asn
         220                 225                 230

 gca gca tat tca ttt aac cag aat gcc ata cgt gaa ttg ggt ggt gtc     1073
 Ala Ala Tyr Ser Phe Asn Gln Asn Ala Ile Arg Glu Leu Gly Gly Val
     235                 240                 245

 cca att att gca aaa ctg ata aaa aca aaa gac ccc ata att agg gaa     1121
 Pro Ile Ile Ala Lys Leu Ile Lys Thr Lys Asp Pro Ile Ile Arg Glu
 250                 255                 260                 265

 aag act tac aat gcc ctt aat aac ttg agt gtg aac gca gaa aat cag     1169
 Lys Thr Tyr Asn Ala Leu Asn Asn Leu Ser Val Asn Ala Glu Asn Gln
                 270                 275                 280

 ggc aag att aag acg tac atc agt caa gtg tgt gat gac acc atg gtc     1217
 Gly Lys Ile Lys Thr Tyr Ile Ser Gln Val Cys Asp Asp Thr Met Val
             285                 290                 295

 tgt cgc ttg gac tca gct gtg cag atg gct ggg cta aga ctg tta acc     1265
 Cys Arg Leu Asp Ser Ala Val Gln Met Ala Gly Leu Arg Leu Leu Thr
         300                 305                 310

 aac atg act gtg act aat cat tac caa cat ttg ctt tcc tat tct ttt     1313
 Asn Met Thr Val Thr Asn His Tyr Gln His Leu Leu Ser Tyr Ser Phe
     315                 320                 325

 cca gac ttt ttt gct ttg tta ttc ctg gga aat cac ttc acc aag ata     1361
 Pro Asp Phe Phe Ala Leu Leu Phe Leu Gly Asn His Phe Thr Lys Ile
 330                 335                 340                 345

 cag att atg aaa cta att ata aac ttt act gaa aat cca gcc atg aca     1409
 Gln Ile Met Lys Leu Ile Ile Asn Phe Thr Glu Asn Pro Ala Met Thr
                 350                 355                 360

 aga gag ctg gtc agt tgt aaa gta cca tca gaa ttg att tcc ctc ttt     1457
 Arg Glu Leu Val Ser Cys Lys Val Pro Ser Glu Leu Ile Ser Leu Phe
             365                 370                 375

 aat aaa gaa tgg gat aga gag att ctt ctt aat atc ctt acc cta ttt     1505
 Asn Lys Glu Trp Asp Arg Glu Ile Leu Leu Asn Ile Leu Thr Leu Phe
         380                 385                 390

 gag aat ata aat gac aac ata aaa aat gaa ggg ctc gca tca tcc agg     1553
 Glu Asn Ile Asn Asp Asn Ile Lys Asn Glu Gly Leu Ala Ser Ser Arg
     395                 400                 405

 aaa gaa ttc agc aga agt tca ctt ttt ttc tta ttc aaa gag tct gga     1601
 Lys Glu Phe Ser Arg Ser Ser Leu Phe Phe Leu Phe Lys Glu Ser Gly
 410                 415                 420                 425

 gtt tgt gtt aag aaa atc aaa gca cta gca aat cac aat gat ctg gtg     1649
 Val Cys Val Lys Lys Ile Lys Ala Leu Ala Asn His Asn Asp Leu Val
                 430                 435                 440

 gtg aaa gta aaa gtc ctg aaa gta tta acc aaa ctc taat ttggagtctg     1699
 Val Lys Val Lys Val Leu Lys Val Leu Thr Lys Leu 
             445                 450

 tcccaaacaa tattgagata tttgcagttg gtacgatgtg atttgtaaat tctttgtttt   1759

 tcattgtgcg tatatggtaa agagatcttt tcagctgcta ttttggaata atgactatca   1819

 tatatcataa cagtgactga tgttggttgt aatggttggg tttaggatga accattttaa   1879

 ggatgccaaa tgaaatatta gtatttgtac acagaaagaa tttattgatt tgatcttatt   1939

 acctagattg agatttttta atctttcctc tacctaaact gacaatgaat tggttataca   1999

 tcatgcataa gctacacttt tatattagtt tatatttgtt attctaagac ttgtgtttca   2059

 tcaataaagt tgtgttttaa gcagcagaaa aaaaaaaaaa aaa                     2102




      <210> 157
      <211> 1524
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (151)..(915)

      <400> 157
 gtcaaagaga caaactccat tttcttatga atggaaagtg aaaacccctg ttccgcttaa     60

 attgggttcc ttcctgtcct gagaaacata gagaccccca aaagggaagc agaggagaga    120

 aagtcccaca cccagacccc gcgagaagag     atg acc atg acc acc atg cca     171
                                      Met Thr Met Thr Thr Met Pro
                                        1               5

 gaa agt ctc aac agc ccc gtg tcg ggc aag gcg gtg ttt atg gag ttt      219
 Glu Ser Leu Asn Ser Pro Val Ser Gly Lys Ala Val Phe Met Glu Phe
          10                  15                  20

 ggg ccg ccc aac cag caa atg tct cct tcc ccc atg tcc cac ggg cac      267
 Gly Pro Pro Asn Gln Gln Met Ser Pro Ser Pro Met Ser His Gly His
      25                  30                  35

 tac tcc atg cac tgt tta cac tcg gcg ggc cat tcg cag ccc gac ggc      315
 Tyr Ser Met His Cys Leu His Ser Ala Gly His Ser Gln Pro Asp Gly
  40                  45                  50                  55

 gcc tac agc tca gcc tcg tcc ttc tcc cga ccg ctg ggc tac ccc tac      363
 Ala Tyr Ser Ser Ala Ser Ser Phe Ser Arg Pro Leu Gly Tyr Pro Tyr
                  60                  65                  70

 gtc aac tcg gtc agc agc cac gca tcc agc ccc tac atc agt tcg gtg      411
 Val Asn Ser Val Ser Ser His Ala Ser Ser Pro Tyr Ile Ser Ser Val
              75                  80                  85

 cag tcc tac ccg ggc agc gcc agc ctc gcc cag agc cgc ctg gag gac      459
 Gln Ser Tyr Pro Gly Ser Ala Ser Leu Ala Gln Ser Arg Leu Glu Asp
          90                  95                 100

 cca ggg gcg gac tcg gag aag agc acg gtg gtg gaa ggc ggt gaa gtg      507
 Pro Gly Ala Asp Ser Glu Lys Ser Thr Val Val Glu Gly Gly Glu Val
     105                 110                 115

 cgc ttc aat ggc aag gga aaa aag atc cgt aaa ccc agg acg att tat      555
 Arg Phe Asn Gly Lys Gly Lys Lys Ile Arg Lys Pro Arg Thr Ile Tyr
 120                 125                 130                 135

 tcc agt ttg cag ttg cag gct ttg aac cgg agg ttc cag caa act cag      603
 Ser Ser Leu Gln Leu Gln Ala Leu Asn Arg Arg Phe Gln Gln Thr Gln
                 140                 145                 150

 tac cta gct ctg ccg gag agg gcg gag ctc gcg gcc tct ttg gga ctc      651
 Tyr Leu Ala Leu Pro Glu Arg Ala Glu Leu Ala Ala Ser Leu Gly Leu
             155                 160                 165

 aca cag act cag gtc aag atc tgg ttc caa aac aag cga tcc aag ttc      699
 Thr Gln Thr Gln Val Lys Ile Trp Phe Gln Asn Lys Arg Ser Lys Phe
         170                 175                 180

 aag aag ctg atg aag cag ggt ggg gcg gct ctg gag ggt agt gcg ttg      747
 Lys Lys Leu Met Lys Gln Gly Gly Ala Ala Leu Glu Gly Ser Ala Leu
     185                 190                 195

 gcc aac ggg cgg gcc ctg tct gct ggc tcc cca ccc gtg ccg ccc ggc      795
 Ala Asn Gly Arg Ala Leu Ser Ala Gly Ser Pro Pro Val Pro Pro Gly
 200                 205                 210                 215

 tgg aac cct aac tct tca tcc ggg aag ggc tca gga gga aac gcg ggc      843
 Trp Asn Pro Asn Ser Ser Ser Gly Lys Gly Ser Gly Gly Asn Ala Gly
                 220                 225                 230

 tcc tat atc ccc agc tac aca tcg tgg tac cct tca gcg cac caa gaa      891
 Ser Tyr Ile Pro Ser Tyr Thr Ser Trp Tyr Pro Ser Ala His Gln Glu
             235                 240                 245

 gct atg cag caa ccc caa ctt atg tgaggttgcc cgcccgtctc cttcttgtct     945
 Ala Met Gln Gln Pro Gln Leu Met 
         250                 255

 ccccggccca ggtccctccc gcctccaggt ccatccatcc cgtccggaaa agaaggaccc   1005

 agagggaaga aggaacagtg gaggcgggac gccctccatc tcctcggagc cccgcgaggt   1065

 ccggcccagc aacttcccgg catccgcgct ctagcctgaa ccctggcctg ggccgagcag   1125

 tggcagcaga gagtggcctc ggagggaagc cactgccacc tgagacagcc caagcagcaa   1185

 gataaacccg ctccacccga cccgccgacc ttcagctttg tgggactatc aggaaaaaac   1245

 aaaacaaaaa caaaatgtag aaaaagcaaa agctcttttc tgtcctgtca gtctcctgtc   1305

 tccttttgct ctgtctgtgc gctggtaaag tccaggtcct catccgtccg ctgtcctcat   1365

 tctgcggcct cagcaaaaag ccacaaggtc tgagcggccc gggtcctgcc gggctgacca   1425

 tctccggatc ctgggacact ctgcctgacc atctgtgtag ctggtgtggg aatctggggg   1485

 cattggaggg agggggttta cgaaatcgtc gacagcgaa                          1524




      <210> 158
      <211> 4177
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (94)..(3177)

      <400> 158
 ctggctggga gcagaaggca gcctcggtct ctgggcggcg gcggcggccc actctgccct     60

 ggccgcgctg tgtggtgacc gcaggcccga gac atg agg gcg gcc cgt gct ctg     114
                                      Met Arg Ala Ala Arg Ala Leu
                                        1               5

 ctg ccc ctg ctg ctg cag gcc tgc tgg aca gcc gcg cag gat gag ccg      162
 Leu Pro Leu Leu Leu Gln Ala Cys Trp Thr Ala Ala Gln Asp Glu Pro
          10                  15                  20

 gag acc ccg agg gcc gtg gcc ttc cag gac tgc ccc gtg gac ctg ttc      210
 Glu Thr Pro Arg Ala Val Ala Phe Gln Asp Cys Pro Val Asp Leu Phe
      25                  30                  35

 ttt gtg ctg gac acc tct gag agc gtg gcc ctg agg ctg aag ccc tac      258
 Phe Val Leu Asp Thr Ser Glu Ser Val Ala Leu Arg Leu Lys Pro Tyr
  40                  45                  50                  55

 ggg gcc ctc gtg gac aaa gtc aag tcc ttc acc aag cgc ttc atc gac      306
 Gly Ala Leu Val Asp Lys Val Lys Ser Phe Thr Lys Arg Phe Ile Asp
                  60                  65                  70

 aac ctg agg gac agg tac tac cgc tgt gac cga aac ctg gtg tgg aac      354
 Asn Leu Arg Asp Arg Tyr Tyr Arg Cys Asp Arg Asn Leu Val Trp Asn
              75                  80                  85

 gca ggc gcg ctg cac tac agt gac gag gtg gag atc atc caa ggc ctc      402
 Ala Gly Ala Leu His Tyr Ser Asp Glu Val Glu Ile Ile Gln Gly Leu
          90                  95                 100

 acg cgc atg cct ggc ggc cgc gac gca ctc aaa agc agc gtg gac gcg      450
 Thr Arg Met Pro Gly Gly Arg Asp Ala Leu Lys Ser Ser Val Asp Ala
     105                 110                 115

 gtc aag tac ttt ggg aag ggc acc tac acc gac tgc gct atc aag aag      498
 Val Lys Tyr Phe Gly Lys Gly Thr Tyr Thr Asp Cys Ala Ile Lys Lys
 120                 125                 130                 135

 ggg ctg gag cag ctc ctc gtg ggg ggc tcc cac ctg aag gag aat aag      546
 Gly Leu Glu Gln Leu Leu Val Gly Gly Ser His Leu Lys Glu Asn Lys
                 140                 145                 150

 tac ctg att gtg gtg acc gac ggg cac ccc ctg gag ggc tac aag gaa      594
 Tyr Leu Ile Val Val Thr Asp Gly His Pro Leu Glu Gly Tyr Lys Glu
             155                 160                 165

 ccc tgt ggg ggg ctg gag gat gct gtg aac gag gcc aag cac ctg ggc      642
 Pro Cys Gly Gly Leu Glu Asp Ala Val Asn Glu Ala Lys His Leu Gly
         170                 175                 180

 gtc aaa gtc ttc tcg gtg gcc atc aca ccc gac cac ctg gag ccg cgt      690
 Val Lys Val Phe Ser Val Ala Ile Thr Pro Asp His Leu Glu Pro Arg
     185                 190                 195

 ctg agc atc atc gcc acg gac cac acg tac cgg cgc aac ttc acg gcg      738
 Leu Ser Ile Ile Ala Thr Asp His Thr Tyr Arg Arg Asn Phe Thr Ala
 200                 205                 210                 215

 gct gac tgg ggc cag agc cgc gac gca gag gag gcc atc agc cag acc      786
 Ala Asp Trp Gly Gln Ser Arg Asp Ala Glu Glu Ala Ile Ser Gln Thr
                 220                 225                 230

 atc gac acc atc gtg gac atg atc aaa aat aac gtg gag caa gtg tgc      834
 Ile Asp Thr Ile Val Asp Met Ile Lys Asn Asn Val Glu Gln Val Cys
             235                 240                 245

 tgc tcc ttc gaa tgc cag cct gca aga gga cct ccg ggg ctc cgg ggc      882
 Cys Ser Phe Glu Cys Gln Pro Ala Arg Gly Pro Pro Gly Leu Arg Gly
         250                 255                 260

 gac ccc ggc ttt gag gga gaa cga ggc aag ccg ggg ctc cca gga gag      930
 Asp Pro Gly Phe Glu Gly Glu Arg Gly Lys Pro Gly Leu Pro Gly Glu
     265                 270                 275

 aag gga gaa gcc gga gat cct gga aga ccc ggg gac ctc gga cct gtt      978
 Lys Gly Glu Ala Gly Asp Pro Gly Arg Pro Gly Asp Leu Gly Pro Val
 280                 285                 290                 295

 ggg tac cag gga atg aag gga gaa aaa ggg agc cgt ggg gag aag ggc     1026
 Gly Tyr Gln Gly Met Lys Gly Glu Lys Gly Ser Arg Gly Glu Lys Gly
                 300                 305                 310

 tcc agg gga ccc aag ggc tac aag gga gag aag ggc aag cgt ggc atc     1074
 Ser Arg Gly Pro Lys Gly Tyr Lys Gly Glu Lys Gly Lys Arg Gly Ile
             315                 320                 325

 gac ggg gtg gac ggc gtg aag ggg gag atg ggg tac cca ggc ctg cca     1122
 Asp Gly Val Asp Gly Val Lys Gly Glu Met Gly Tyr Pro Gly Leu Pro
         330                 335                 340

 ggc tgc aag ggc tcg ccc ggg ttt gac ggc att caa gga ccc cct ggc     1170
 Gly Cys Lys Gly Ser Pro Gly Phe Asp Gly Ile Gln Gly Pro Pro Gly
     345                 350                 355

 ccc aag gga gac ccc ggc gcc ttt gga ctg aaa gga gaa aag ggc gag     1218
 Pro Lys Gly Asp Pro Gly Ala Phe Gly Leu Lys Gly Glu Lys Gly Glu
 360                 365                 370                 375

 cct gga gct gac ggg gag gcg ggg aga cca ggg agc tcg gga cca tct     1266
 Pro Gly Ala Asp Gly Glu Ala Gly Arg Pro Gly Ser Ser Gly Pro Ser
                 380                 385                 390

 gga gac gag ggc cag ccg gga gag cct ggg ccc ccc gga gag aaa gga     1314
 Gly Asp Glu Gly Gln Pro Gly Glu Pro Gly Pro Pro Gly Glu Lys Gly
             395                 400                 405

 gag gcg ggc gac gag ggg aac cca gga cct gac ggt gcc ccc ggg gag     1362
 Glu Ala Gly Asp Glu Gly Asn Pro Gly Pro Asp Gly Ala Pro Gly Glu
         410                 415                 420

 cgg ggt ggc cct gga gag aga gga cca cgg ggg acc cca ggc acg cgg     1410
 Arg Gly Gly Pro Gly Glu Arg Gly Pro Arg Gly Thr Pro Gly Thr Arg
     425                 430                 435

 gga cca aga gga gac cct ggt gaa gct ggc ccg cag ggt gat cag gga     1458
 Gly Pro Arg Gly Asp Pro Gly Glu Ala Gly Pro Gln Gly Asp Gln Gly
 440                 445                 450                 455

 aga gaa ggc ccc gtt ggt gtc cct gga gac ccg ggc gag gct ggc cct     1506
 Arg Glu Gly Pro Val Gly Val Pro Gly Asp Pro Gly Glu Ala Gly Pro
                 460                 465                 470

 atc gga cct aaa ggc tac cga ggc gat gag ggt ccc cca ggg tcc gag     1554
 Ile Gly Pro Lys Gly Tyr Arg Gly Asp Glu Gly Pro Pro Gly Ser Glu
             475                 480                 485

 ggt gcc aga gga gcc cca gga cct gcc gga ccc cct gga gac ccg ggg     1602
 Gly Ala Arg Gly Ala Pro Gly Pro Ala Gly Pro Pro Gly Asp Pro Gly
         490                 495                 500

 ctg atg ggt gaa agg gga gaa gac ggc ccc gct gga aat ggc acc gag     1650
 Leu Met Gly Glu Arg Gly Glu Asp Gly Pro Ala Gly Asn Gly Thr Glu
     505                 510                 515

 ggc ttc ccc ggc ttc ccc ggg tat ccg ggc aac agg ggc gct ccc ggg     1698
 Gly Phe Pro Gly Phe Pro Gly Tyr Pro Gly Asn Arg Gly Ala Pro Gly
 520                 525                 530                 535

 ata aac ggc acg aag ggc tac ccc ggc ctc aag ggg gac gag gga gaa     1746
 Ile Asn Gly Thr Lys Gly Tyr Pro Gly Leu Lys Gly Asp Glu Gly Glu
                 540                 545                 550

 gcc ggg gac ccc gga gac gat aac aac gac att gca ccc cga gga gtc     1794
 Ala Gly Asp Pro Gly Asp Asp Asn Asn Asp Ile Ala Pro Arg Gly Val
             555                 560                 565

 aaa gga gca aag ggg tac cgg ggt ccc gag ggc ccc cag gga ccc cca     1842
 Lys Gly Ala Lys Gly Tyr Arg Gly Pro Glu Gly Pro Gln Gly Pro Pro
         570                 575                 580

 gga cac caa gga ccg cct ggg ccg gac gaa tgc gag att ttg gac atc     1890
 Gly His Gln Gly Pro Pro Gly Pro Asp Glu Cys Glu Ile Leu Asp Ile
     585                 590                 595

 atc atg aaa atg tgc tct tgc tgt gaa tgc aag tgc ggc ccc atc gac     1938
 Ile Met Lys Met Cys Ser Cys Cys Glu Cys Lys Cys Gly Pro Ile Asp
 600                 605                 610                 615

 ctc ctg ttc gtg ctg gac agc tca gag agc att ggc ctg cag aac ttc     1986
 Leu Leu Phe Val Leu Asp Ser Ser Glu Ser Ile Gly Leu Gln Asn Phe
                 620                 625                 630

 gag att gcc aag gac ttc gtc gtc aag gtc atc gac cgg ctg agc cgg     2034
 Glu Ile Ala Lys Asp Phe Val Val Lys Val Ile Asp Arg Leu Ser Arg
             635                 640                 645

 gac gag ctg gtc aag ttc gag cca ggg cag tcg tac gcg ggt gtg gtg     2082
 Asp Glu Leu Val Lys Phe Glu Pro Gly Gln Ser Tyr Ala Gly Val Val
         650                 655                 660

 cag tac agc cac agc cag atg cag gag cac gtg agc ctg cgc agc ccc     2130
 Gln Tyr Ser His Ser Gln Met Gln Glu His Val Ser Leu Arg Ser Pro
     665                 670                 675

 agc atc cgg aac gtg cag gag ctc aag gaa gcc atc aag agc ctg cag     2178
 Ser Ile Arg Asn Val Gln Glu Leu Lys Glu Ala Ile Lys Ser Leu Gln
 680                 685                 690                 695

 tgg atg gcg ggc ggc acc ttc acg ggg gag gcc ctg cag tac acg cgg     2226
 Trp Met Ala Gly Gly Thr Phe Thr Gly Glu Ala Leu Gln Tyr Thr Arg
                 700                 705                 710

 gac cag ctg ctg ccg ccc agc ccg aac aac cgc atc gcc ctg gtc atc     2274
 Asp Gln Leu Leu Pro Pro Ser Pro Asn Asn Arg Ile Ala Leu Val Ile
             715                 720                 725

 act gac ggg cgc tca gac act cag agg gac acc aca ccg ctc aac gtg     2322
 Thr Asp Gly Arg Ser Asp Thr Gln Arg Asp Thr Thr Pro Leu Asn Val
         730                 735                 740

 ctc tgc agc ccc ggc atc cag gtg gtc tcc gtg ggc atc aaa gac gtg     2370
 Leu Cys Ser Pro Gly Ile Gln Val Val Ser Val Gly Ile Lys Asp Val
     745                 750                 755

 ttt gac ttc atc cca ggc tca gac cag ctc aat gtc att tct tgc caa     2418
 Phe Asp Phe Ile Pro Gly Ser Asp Gln Leu Asn Val Ile Ser Cys Gln
 760                 765                 770                 775

 ggc ctg gca cca tcc cag ggc cgg ccc ggc ctc tcg ctg gtc aag gag     2466
 Gly Leu Ala Pro Ser Gln Gly Arg Pro Gly Leu Ser Leu Val Lys Glu
                 780                 785                 790

 aac tat gca gag ctg ctg gag gat gcc ttc ctg aag aat gtc acc gcc     2514
 Asn Tyr Ala Glu Leu Leu Glu Asp Ala Phe Leu Lys Asn Val Thr Ala
             795                 800                 805

 cag atc tgc ata gac aag aag tgt cca gat tac acc tgc ccc atc acg     2562
 Gln Ile Cys Ile Asp Lys Lys Cys Pro Asp Tyr Thr Cys Pro Ile Thr
         810                 815                 820

 ttc tcc tcc ccg gct gac atc acc atc ctg ctg gac ggc tcc gcc agc     2610
 Phe Ser Ser Pro Ala Asp Ile Thr Ile Leu Leu Asp Gly Ser Ala Ser
     825                 830                 835

 gtg ggc agc cac aac ttt gac acc acc aag cgc ttc gcc aag cgc ctg     2658
 Val Gly Ser His Asn Phe Asp Thr Thr Lys Arg Phe Ala Lys Arg Leu
 840                 845                 850                 855

 gcc gag cgc ttc ctc aca gcg ggc agg acg gac ccc gcc cac gac gtg     2706
 Ala Glu Arg Phe Leu Thr Ala Gly Arg Thr Asp Pro Ala His Asp Val
                 860                 865                 870

 cgg gtg gcg gtg gtg cag tac agc ggc acg ggc cag cag cgc cca gag     2754
 Arg Val Ala Val Val Gln Tyr Ser Gly Thr Gly Gln Gln Arg Pro Glu
             875                 880                 885

 cgg gcg tcg ctg cag ttc ctg cag aac tac acg gcc ctg gcc agt gcc     2802
 Arg Ala Ser Leu Gln Phe Leu Gln Asn Tyr Thr Ala Leu Ala Ser Ala
         890                 895                 900

 gtc gat gcc atg gac ttt atc aac gac gcc acc gac gtc aac gat gcc     2850
 Val Asp Ala Met Asp Phe Ile Asn Asp Ala Thr Asp Val Asn Asp Ala
     905                 910                 915

 ctg ggc tat gtg acc cgc ttc tac cgc gag gcc tcg tcc ggc gct gcc     2898
 Leu Gly Tyr Val Thr Arg Phe Tyr Arg Glu Ala Ser Ser Gly Ala Ala
 920                 925                 930                 935

 aag aag agg ctg ctg ctc ttc tca gat ggc aac tcg cag ggc gcc acg     2946
 Lys Lys Arg Leu Leu Leu Phe Ser Asp Gly Asn Ser Gln Gly Ala Thr
                 940                 945                 950

 ccc gct gcc atc gag aag gcc gtg cag gaa gcc cag cgg gca ggc atc     2994
 Pro Ala Ala Ile Glu Lys Ala Val Gln Glu Ala Gln Arg Ala Gly Ile
             955                 960                 965

 gag atc ttc gtg gtg gtc gtg ggc cgc cag gtg aat gag ccc cac atc     3042
 Glu Ile Phe Val Val Val Val Gly Arg Gln Val Asn Glu Pro His Ile
         970                 975                 980

 cgc gtc ctg gtc acc ggc aag acg gcc gag tac gac gtg gcc tac ggc     3090
 Arg Val Leu Val Thr Gly Lys Thr Ala Glu Tyr Asp Val Ala Tyr Gly
     985                 990                 995

 gag agc cac ctg ttc cgt gtc ccc agc tac cag gcc ctg ctc cgc ggt     3138
 Glu Ser His Leu Phe Arg Val Pro Ser Tyr Gln Ala Leu Leu Arg Gly
1000                1005                1010                1015

 gtc ttc cac cag aca gtc tcc agg aag gtg gcg ctg ggc tagcccaccc      3187
 Val Phe His Gln Thr Val Ser Arg Lys Val Ala Leu Gly 
                1020                1025

 tgcacgccgg caccaaaccc tgtcctccca cccctcccca ctcatcacta aacagagaaa   3247

 agcttggaaa gccaggacac aacgctgctg cctgctttgt gcagggtcct ccggggctca   3307

 gccctgagtt ggcatcacct gcgcagggcc ctctggggct cagccctgag ctagtgtcac   3367

 ctgcacaggg ccctctgggg ctcagccctg agctggcgtc acctgtgcag ggccctctgg   3427

 ggctcagccc tgagctggcc tcacctgggt tccccacccc gggctctcct gccctgccct   3487

 cctgcccgcc ctccctcctg cctgcgcagc tccttcccta ggcacctctg tgctgcgtcc   3547

 caccagcctg agcaagacgc cctctcgggg cctgtgccgc actagcctcc ctctcctctg   3607

 tccccatagc tggtttttcc caccaatcct cacctaacag ttactttaca attaaactca   3667

 aagcaagctc ttctcctcag cttggggcag ccattggcct ctgtctcgtt ttgggaaacc   3727

 aaggtcagga ggccgttgca gacataaatc tcggcgactc ggccccgtct cctgagggtc   3787

 ctgctggtga ccggcctgga ccttggccct acagccctgg aggccgctgc tgaccagcac   3847

 tgaccccgac ctcagagagt actcgcaggg gcgctggctg cactcaagac cctcgagatt   3907

 aacggtgcta accccgtctg ctcctccctc ccgcagagac tggggcctgg actggacatg   3967

 agagcccctt ggtgccacag agggctgtgt cttactagaa acaacgcaaa cctctccttc   4027

 ctcagaatag tgatgtgttc gacgttttat caaaggcccc ctttctatgt tcatgttagt   4087

 tttgctcctt ctgtgttttt ttctgaacca tatccatgtt gctgactttt ccaaataaag   4147

 gttttcactc ctcaaaaaaa aaaaaaaaag                                    4177




      <210> 159
      <211> 1474
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (864)..(1421)

      <400> 159
 taagcttgcg gccgctgaac tacagctctg cgcctgccca ggcggccgca cgctcagggg     60

 cgtggcatgg gtgggtcgtg agttgggcgg ggcccacagg gcgtgcgcga cgcagcggcg    120

 cggcgcgagg cgtaaggggc gtggcgccag tgggcgtggc gtggcgcagt gcgaagggac    180

 gcggtgcgca tgcgcgtgag ggcttccacg ggtgggtggt atcgaggcct gtcgggtcag    240

 ggcggttcgc gggtgctgtc agagctgggc cggggcccct aggcaggccc agacatgtcc    300

 gtccttgtaa gttaaaagct tccatgggag ccttccttcc taatcaagat gcaaatagta    360

 cggtattccg aacagacact aaaaatagct gtcatctcaa agaatccagt gcttgtgtca    420

 cagtatgaga aagtagatgc tggggaacag cgtttaatga atgaggcatg caagccagcc    480

 agtgatctct ttggaccttg cattctccat cagattggat cacctcccac cctgaggccc    540

 cccaagactt tgaacagttc ttcagtcatc cttacagaaa gataccctct ccagacaaac    600

 gcagtattta tatacggtcc attggatctc tatgaagcac cagaattatc agtgaagaat    660

 atattaaatg gctcacgggc tactgtaaag catatttcta tcgcttgaga gtaaaactcc    720

 tagaaccagt tcctgtttct gtaacaagat gttcctttag agtcaatgag aacacacaca    780

 acctacaaat tcatgcaggg gacatcctga agttcttgaa aaagaagaaa cctgaagatg    840

 ccttctgtgt tgtgggaata aca    atg att gat ctt tac cca aga gac tcg     890
                              Met Ile Asp Leu Tyr Pro Arg Asp Ser
                                1               5

 tgg aat ttt gtc ttt gga cag gcc tct ttg aca gat ggt gtg ggg ata      938
 Trp Asn Phe Val Phe Gly Gln Ala Ser Leu Thr Asp Gly Val Gly Ile
  10                  15                  20                  25

 ttc agc ttt gcc agg tat ggc agt gat ttt tat agc atg cac tat aaa      986
 Phe Ser Phe Ala Arg Tyr Gly Ser Asp Phe Tyr Ser Met His Tyr Lys
                  30                  35                  40

 ggc aaa gtg aag aag ctc aag aaa aca tct tca agt gac tat tca att     1034
 Gly Lys Val Lys Lys Leu Lys Lys Thr Ser Ser Ser Asp Tyr Ser Ile
              45                  50                  55

 ttc gac aac tat tat att cca gaa ata act agt gtt tta cta ctt cga     1082
 Phe Asp Asn Tyr Tyr Ile Pro Glu Ile Thr Ser Val Leu Leu Leu Arg
          60                  65                  70

 tcc tgt aag act tta acc cat gag atc gga cac ata ttt gga ctg cga     1130
 Ser Cys Lys Thr Leu Thr His Glu Ile Gly His Ile Phe Gly Leu Arg
      75                  80                  85

 cac tgc cag tgg ctt gca tgc ctc atg caa ggc tcc aac cac ttg gaa     1178
 His Cys Gln Trp Leu Ala Cys Leu Met Gln Gly Ser Asn His Leu Glu
  90                  95                 100                 105

 gaa gct gac cgg cgc cct cta aac ctt tgc cct atc tgt ttg cac aag     1226
 Glu Ala Asp Arg Arg Pro Leu Asn Leu Cys Pro Ile Cys Leu His Lys
                 110                 115                 120

 ttg cag tgt gct gtt ggc ttc agc att gta gaa aga tac aaa gca ctg     1274
 Leu Gln Cys Ala Val Gly Phe Ser Ile Val Glu Arg Tyr Lys Ala Leu
             125                 130                 135

 gtg agg tgg att gat gat gaa tct tct gac aca cct gga gca act cca     1322
 Val Arg Trp Ile Asp Asp Glu Ser Ser Asp Thr Pro Gly Ala Thr Pro
         140                 145                 150

 gaa cac agt cac gag gat aat ggg aat tta ccg aaa ccc gtg gaa gcc     1370
 Glu His Ser His Glu Asp Asn Gly Asn Leu Pro Lys Pro Val Glu Ala
     155                 160                 165

 ttt aag gaa tgg aaa gag tgg ata ata aaa tgc ctg gct gtt ctc caa     1418
 Phe Lys Glu Trp Lys Glu Trp Ile Ile Lys Cys Leu Ala Val Leu Gln
 170                 175                 180                 185

 aaa tgaggacctt caaataggag tgattgaaat aaataactac ttgcatgtta tgc      1474
 Lys 






      <210> 160
      <211> 882
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (147)..(281)

      <400> 160
 gagccgagat cacgccactg cactccagcc tgggcaacaa gagcaaaact ctgtctcaat     60

 aaaaaaaaag gaaaacccac agccaacatt atcactagtg gtaacaggga aaatgtcccc    120

 tttgaccccc accccaagta cagaac atg caa gga cgc ctg ttc tca ctg cat     173
                              Met Gln Gly Arg Leu Phe Ser Leu His
                                1               5

 gtc ttc tgt gtt gta ctg aag ctc cta gct ggt gca gtg agg caa gac      221
 Val Phe Cys Val Val Leu Lys Leu Leu Ala Gly Ala Val Arg Gln Asp
  10                  15                  20                  25

 aaa gaa agg aaa tat agg tgc act ggg aag gaa gaa gaa aca ctg cct      269
 Lys Glu Arg Lys Tyr Arg Cys Thr Gly Lys Glu Glu Glu Thr Leu Pro
                  30                  35                  40

 tta ttc ttt agg tga catgattgtg tgcttttaaa ataataaagg aatcaacaga      324
 Leu Phe Phe Arg 
              45

 aaagttgctt aacctaatga atgagtttat caaagtcaca agatacaagg tcagtataca    384

 aaaatcagtt ggatttctac atggtagaaa caactgtaca tggaaaaatg tttaatagtg    444

 taagatatgt acattggaaa ctatgaaaga gtgtaaaaaa taaagaagtg aaataaatgg    504

 agaagatacc accttgatgg atggaagcct taaggtaaag atgctcattc tccccacact    564

 gacctgtaca ttccccacag gcctaatcaa aacccccaca ggcttctgtg tagaaattga    624

 catgctgatc ctgaaattta tatgaaaatg caaagagtct ggaataacca aaataatttt    684

 gtaaaagaac aaagaagact tctactacct ggttataaga cttctctgaa gcacagaagt    744

 caaggcagtg tggtggtggc ataagtaatg taaatcatcc aggtgtggtg gctcaagcca    804

 gtcatccagc actttgggag gctgaggcag gagaatcgct agagcccagg agttggaaac    864

 cagcctgggc agcatagc                                                  882




      <210> 161
      <211> 442
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(333)

      <400> 161
 gctccggaat tcccgggaac atttacactg acagcaagta cgccttagct actgtgc        57                                                                 
 atg tac ata aag cca tct acc agg aaa tca ggc tac tca cct cag cag      105
 Met Tyr Ile Lys Pro Ser Thr Arg Lys Ser Gly Tyr Ser Pro Gln Gln
   1               5                  10                  15

 gta gct gtg atc cac tgc aaa gga cat caa aaa gaa aac acg gcc gtt      153
 Val Ala Val Ile His Cys Lys Gly His Gln Lys Glu Asn Thr Ala Val
              20                  25                  30

 gcc cat agt aac cag aaa gct gat tca gca gct cag gtc act gcc aga      201
 Ala His Ser Asn Gln Lys Ala Asp Ser Ala Ala Gln Val Thr Ala Arg
          35                  40                  45

 ctt tca gtc acg cct cca aac ttg ctg ccc aca gtc tcc ttt cca cag      249
 Leu Ser Val Thr Pro Pro Asn Leu Leu Pro Thr Val Ser Phe Pro Gln
      50                  55                  60

 cca gat ctg cct gac aat ccc gta tac tca aca aca aca gaa aaa ctg      297
 Pro Asp Leu Pro Asp Asn Pro Val Tyr Ser Thr Thr Thr Glu Lys Leu
  65                  70                  75                  80

 gct tca gat ctc aga gcc aat aaa aat cag gaa agt tagt agattcttcc      347
 Ala Ser Asp Leu Arg Ala Asn Lys Asn Gln Glu Ser 
                  85                  90

 tgactctgga atcttcatac cctgaactta aaccagttac ctacagtcta ccacccattt    407

 aagaagagca aagttacctc agctcctccg gaggg                               442




      <210> 162
      <211> 1959
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (173)..(1906)

      <400> 162
 taagcttgcg gccgcccggc ggtgtagatg gtacgcttgc ttgtacgcag caggggaggc     60

 tctgacttgc actggctggt ggtccgcttc cggggagagc gcccagtgcc cacaggtggc    120

 aggagcctgt ccagggactc tgcattgctg ctgcagagag ggatgtactc gg    atg     175
                                                              Met
                                                                1

 tgg ccc aga gct gcc cac ctc cca ggt acc cgc tgg cat ggc cgg ccc      223
 Trp Pro Arg Ala Ala His Leu Pro Gly Thr Arg Trp His Gly Arg Pro
               5                  10                  15

 aca ggg cat ccc ccc cca ccc cca atg agc ctg ccc gcc tca gcc atg      271
 Thr Gly His Pro Pro Pro Pro Pro Met Ser Leu Pro Ala Ser Ala Met
          20                  25                  30

 cct gtt gag ggg gtg ggg ggg gat gcc ctg tgg gcc ggc cat gcc agc      319
 Pro Val Glu Gly Val Gly Gly Asp Ala Leu Trp Ala Gly His Ala Ser
      35                  40                  45

 ggg tac ctg gga ggt ggc cag ctc tgg gcc aca tcc gag tac atc cct      367
 Gly Tyr Leu Gly Gly Gly Gln Leu Trp Ala Thr Ser Glu Tyr Ile Pro
  50                  55                  60                  65

 ctc tgc agc agc aat gca gag tcc ctg gac agg ctc ctg cca cct gtg      415
 Leu Cys Ser Ser Asn Ala Glu Ser Leu Asp Arg Leu Leu Pro Pro Val
                  70                  75                  80

 ggc act ggg cgc tct ccc cgg aag cgg acc acc agc cag tgc aag tca      463
 Gly Thr Gly Arg Ser Pro Arg Lys Arg Thr Thr Ser Gln Cys Lys Ser
              85                  90                  95

 gag cct ccc ctg ctg cgt aca agc aag cgt acc atc tac acc gcc ggg      511
 Glu Pro Pro Leu Leu Arg Thr Ser Lys Arg Thr Ile Tyr Thr Ala Gly
         100                 105                 110

 cgg ccg ccc tgg tac aat gaa cac ggc acg caa tcc aaa gag gcc ttc      559
 Arg Pro Pro Trp Tyr Asn Glu His Gly Thr Gln Ser Lys Glu Ala Phe
     115                 120                 125

 gcc atc ggc ttg gga ggc ggc agt gcc tct ggg aag acc act gtg gcc      607
 Ala Ile Gly Leu Gly Gly Gly Ser Ala Ser Gly Lys Thr Thr Val Ala
 130                 135                 140                 145

 aga atg atc atc gag gcc ctg gat gtg ccc tgg gtg gtc ttg ctg tcc      655
 Arg Met Ile Ile Glu Ala Leu Asp Val Pro Trp Val Val Leu Leu Ser
                 150                 155                 160

 atg gac tcc ttc tac aag gtg ctg act gag cag cag cag gaa cag gcc      703
 Met Asp Ser Phe Tyr Lys Val Leu Thr Glu Gln Gln Gln Glu Gln Ala
             165                 170                 175

 gca cac aac aac ttc aac ttc gac cac cca gat gcc ttt gac ttc gac      751
 Ala His Asn Asn Phe Asn Phe Asp His Pro Asp Ala Phe Asp Phe Asp
         180                 185                 190

 ctc atc att tcc acc ctc aag aag ctg aag cag ggg aag agt gtc aag      799
 Leu Ile Ile Ser Thr Leu Lys Lys Leu Lys Gln Gly Lys Ser Val Lys
     195                 200                 205

 gtg ccc att tat gac ttc acc acg cac agc cgg aag aag gac tgg aaa      847
 Val Pro Ile Tyr Asp Phe Thr Thr His Ser Arg Lys Lys Asp Trp Lys
 210                 215                 220                 225

 aca ctg tat ggt gca aac gtc atc atc ttt gag ggc atc atg gcc ttt      895
 Thr Leu Tyr Gly Ala Asn Val Ile Ile Phe Glu Gly Ile Met Ala Phe
                 230                 235                 240

 gct gac aag aca ctg ttg gag ctc ctg gac atg aag atc ttt gtg gac      943
 Ala Asp Lys Thr Leu Leu Glu Leu Leu Asp Met Lys Ile Phe Val Asp
             245                 250                 255

 aca gac tcc gac atc cgc ctg gta cgg cgg ctg cgc cgg gac atc agt      991
 Thr Asp Ser Asp Ile Arg Leu Val Arg Arg Leu Arg Arg Asp Ile Ser
         260                 265                 270

 gag cgc ggc cgg gac atc gag ggt gtc atc aag cag tac aac aag ttt     1039
 Glu Arg Gly Arg Asp Ile Glu Gly Val Ile Lys Gln Tyr Asn Lys Phe
     275                 280                 285

 gtc aag ccc tcc ttc gac cag tac atc cag ccc acc atg cgc ctg gca     1087
 Val Lys Pro Ser Phe Asp Gln Tyr Ile Gln Pro Thr Met Arg Leu Ala
 290                 295                 300                 305

 gac atc gtg gtc ccc aga ggg agc ggc aac acg gtg gcc atc gac ctg     1135
 Asp Ile Val Val Pro Arg Gly Ser Gly Asn Thr Val Ala Ile Asp Leu
                 310                 315                 320

 att gtg cag cac gtg cac agc cag ctg gag gag cgt gaa ctc agc gtc     1183
 Ile Val Gln His Val His Ser Gln Leu Glu Glu Arg Glu Leu Ser Val
             325                 330                 335

 agg gct gcg ctg gcc tcg gca cac cag tgc cac ccg ctg ccc cgg acg     1231
 Arg Ala Ala Leu Ala Ser Ala His Gln Cys His Pro Leu Pro Arg Thr
         340                 345                 350

 ctg agc gtc ctg aag agc acg ccg cag gta cgg ggc atg cac acc atc     1279
 Leu Ser Val Leu Lys Ser Thr Pro Gln Val Arg Gly Met His Thr Ile
     355                 360                 365

 atc agg gac aag gag acc agt cgc gac gag ttc atc ttc tac tcc aag     1327
 Ile Arg Asp Lys Glu Thr Ser Arg Asp Glu Phe Ile Phe Tyr Ser Lys
 370                 375                 380                 385

 aga ctg atg cgg ctg ctc atc gag cac gcg ctc tcc ttc ctg ccc ttt     1375
 Arg Leu Met Arg Leu Leu Ile Glu His Ala Leu Ser Phe Leu Pro Phe
                 390                 395                 400

 cag gac tgc gtc gta cag acc ccg cag ggg cag gac tat gcg ggc aag     1423
 Gln Asp Cys Val Val Gln Thr Pro Gln Gly Gln Asp Tyr Ala Gly Lys
             405                 410                 415

 tgc tat gcg ggg aag cag atc acc ggt gtg tcc att ctg cgc gcc ggt     1471
 Cys Tyr Ala Gly Lys Gln Ile Thr Gly Val Ser Ile Leu Arg Ala Gly
         420                 425                 430

 gaa acc atg gag ccc gcg ctg cgc gct gtg tgc aaa gac gtg cgc atc     1519
 Glu Thr Met Glu Pro Ala Leu Arg Ala Val Cys Lys Asp Val Arg Ile
     435                 440                 445

 ggc acc atc ctc atc cag acc aac cag ctt acc ggg gag ccc gag ctc     1567
 Gly Thr Ile Leu Ile Gln Thr Asn Gln Leu Thr Gly Glu Pro Glu Leu
 450                 455                 460                 465

 cac tac ctg agg ctg ccc aag gac atc agc gat gac cac gtg atc ctc     1615
 His Tyr Leu Arg Leu Pro Lys Asp Ile Ser Asp Asp His Val Ile Leu
                 470                 475                 480

 atg gac tgc acc gtg tcc acg ggc gcg gcg gcc atg atg gca gtg cgc     1663
 Met Asp Cys Thr Val Ser Thr Gly Ala Ala Ala Met Met Ala Val Arg
             485                 490                 495

 gtg ctc ctg gac cac gac gtg cct gag gac aag atc ttt ttg ctg tcg     1711
 Val Leu Leu Asp His Asp Val Pro Glu Asp Lys Ile Phe Leu Leu Ser
         500                 505                 510

 ctg ctc atg gca gag atg ggc gtg cac tca gtg gcc tat gca ttt ccg     1759
 Leu Leu Met Ala Glu Met Gly Val His Ser Val Ala Tyr Ala Phe Pro
     515                 520                 525

 cga gtg aga atc atc acc acg gcg gtg gac aag cgg gtc aat gac ctt     1807
 Arg Val Arg Ile Ile Thr Thr Ala Val Asp Lys Arg Val Asn Asp Leu
 530                 535                 540                 545

 ttc cgc atc atc cca ggc att ggg aac ttt ggc gac cgc tac ttt ggg     1855
 Phe Arg Ile Ile Pro Gly Ile Gly Asn Phe Gly Asp Arg Tyr Phe Gly
                 550                 555                 560

 aca gac gcg gtc ccc gat ggc agt gac gag gag gaa gtg gcc tac acg     1903
 Thr Asp Ala Val Pro Asp Gly Ser Asp Glu Glu Glu Val Ala Tyr Thr
             565                 570                 575

 ggt tagctgccca gtgagccatc ccgtccccac caccctcctc ctgcctcctg acc      1959
 Gly 






      <210> 163
      <211> 1705
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (545)..(1669)

      <400> 163
 aaggatcctt aattttatta atcccccccc ccccgaaggc ccccagccgc ctgtgccccg     60

 cggtgcgcgc cccgctccgg gacctgccgc caccgccgcc ccgccctcgg cggcacccac    120

 acccaggcgc gcccgcgcgc gcgcccggcc ccgtccctgc ctggaagcac agctgaagat    180

 ggcgagcccg gcgcctccgg agcacgccga ggagggatgc ccggctcctg ccgccgagga    240

 gcaggcgccg ccgtcgccgc caccgcccca ggcatccccc gcagagcggc agcagcagga    300

 ggaggaagcg caggaagctg gggcggcgga gggcgcgggg ttgcaggtgg aggaggccgc    360

 gggccgggcg gcggccgcgg taacctggct gctcggggag ccggtgctgt ggctgggctg    420

 ccgcgccgac gagctgctga gctggaagag gccgctgcgg agcctgctcg gcttcgtcgc    480

 tgccaacctg ctgttctggt tccttgcatt gactccatgg agagtatatc acctgatttc    540

 cgtc atg ata ctt ggg cgt gtt att atg caa ata ata aag gat atg gtt     589
      Met Ile Leu Gly Arg Val Ile Met Gln Ile Ile Lys Asp Met Val
        1               5                  10                  15

 ttg tct aga aca aga ggt gca cag ttg tgg aga agc ctc agt gaa agc      637
 Leu Ser Arg Thr Arg Gly Ala Gln Leu Trp Arg Ser Leu Ser Glu Ser
                  20                  25                  30

 tgg gaa gtt atc aat tcc aaa cca gat gaa aga ccc agg ctc agc cac      685
 Trp Glu Val Ile Asn Ser Lys Pro Asp Glu Arg Pro Arg Leu Ser His
              35                  40                  45

 tgt att gca gaa tca tgg atg aat ttc agc ata ttt ctt caa gaa atg      733
 Cys Ile Ala Glu Ser Trp Met Asn Phe Ser Ile Phe Leu Gln Glu Met
          50                  55                  60

 tct ctt ttt aaa cag cag agc cct ggc aag ttt tgt ctc ctg gtc tgt      781
 Ser Leu Phe Lys Gln Gln Ser Pro Gly Lys Phe Cys Leu Leu Val Cys
      65                  70                  75

 agt gtg tgc aca ttt ttt acg atc ttg gga agt tac att cct ggg gtt      829
 Ser Val Cys Thr Phe Phe Thr Ile Leu Gly Ser Tyr Ile Pro Gly Val
  80                  85                  90                  95

 ata ctc agc tat cta ctg tta ctg tgt gca ttt ttg tgt cca ttg ttt      877
 Ile Leu Ser Tyr Leu Leu Leu Leu Cys Ala Phe Leu Cys Pro Leu Phe
                 100                 105                 110

 aaa tgt aat gat att gga caa aaa att tac agc aaa att aag tca gtt      925
 Lys Cys Asn Asp Ile Gly Gln Lys Ile Tyr Ser Lys Ile Lys Ser Val
             115                 120                 125

 ctg ctg aaa ctg gat ttt gga att gga gaa tat att aat cag aag aaa      973
 Leu Leu Lys Leu Asp Phe Gly Ile Gly Glu Tyr Ile Asn Gln Lys Lys
         130                 135                 140

 cgt gag aga tct gaa gca gat aaa gaa aaa agt cac aaa gat gac agt     1021
 Arg Glu Arg Ser Glu Ala Asp Lys Glu Lys Ser His Lys Asp Asp Ser
     145                 150                 155

 gaa tta gac ttt tca gct ctt tgt cct aag att agc ctc acg gtt gct     1069
 Glu Leu Asp Phe Ser Ala Leu Cys Pro Lys Ile Ser Leu Thr Val Ala
 160                 165                 170                 175

 gcc aaa gag tta tct gtg tct gac aca gac gtc tca gag gta tcc tgg     1117
 Ala Lys Glu Leu Ser Val Ser Asp Thr Asp Val Ser Glu Val Ser Trp
                 180                 185                 190

 act gat aat ggg acc ttc aac ctt tca gaa gga tac act cca cag aca     1165
 Thr Asp Asn Gly Thr Phe Asn Leu Ser Glu Gly Tyr Thr Pro Gln Thr
             195                 200                 205

 gac act tct gat gat ctt gac cga ccc agt gag gaa gtt ttc tct aga     1213
 Asp Thr Ser Asp Asp Leu Asp Arg Pro Ser Glu Glu Val Phe Ser Arg
         210                 215                 220

 gat ctt tca gat ttt cca tct cta gaa aat ggc atg gga aca aat gat     1261
 Asp Leu Ser Asp Phe Pro Ser Leu Glu Asn Gly Met Gly Thr Asn Asp
     225                 230                 235

 gaa gat gaa tta agc ctt ggt ttg ccc act gag ctc aag aga aag aag     1309
 Glu Asp Glu Leu Ser Leu Gly Leu Pro Thr Glu Leu Lys Arg Lys Lys
 240                 245                 250                 255

 gaa cag ttg gac agt ggt cac aga cca agc aaa gag acg caa tca gca     1357
 Glu Gln Leu Asp Ser Gly His Arg Pro Ser Lys Glu Thr Gln Ser Ala
                 260                 265                 270

 gct ggt ctc acc ctt cct ctg aac agt gac caa acc ttt cac ctg atg     1405
 Ala Gly Leu Thr Leu Pro Leu Asn Ser Asp Gln Thr Phe His Leu Met
             275                 280                 285

 agc aac ctg gct ggg gat gtt atc aca gct gca gtg act gca gct atc     1453
 Ser Asn Leu Ala Gly Asp Val Ile Thr Ala Ala Val Thr Ala Ala Ile
         290                 295                 300

 aaa gac cag tta gag ggt gtg cag caa gca ctt tct cag gct gcc ccc     1501
 Lys Asp Gln Leu Glu Gly Val Gln Gln Ala Leu Ser Gln Ala Ala Pro
     305                 310                 315

 atc cca gaa gag gac aca gac act gaa gaa ggt gat gac ttt gaa cta     1549
 Ile Pro Glu Glu Asp Thr Asp Thr Glu Glu Gly Asp Asp Phe Glu Leu
 320                 325                 330                 335

 ctt gac cag tca gag ctg gat caa att gag agt gaa ttg gga ctt aca     1597
 Leu Asp Gln Ser Glu Leu Asp Gln Ile Glu Ser Glu Leu Gly Leu Thr
                 340                 345                 350

 caa gac cag gaa gca gaa gca cag caa aat aag aag tct tca ggt ttc     1645
 Gln Asp Gln Glu Ala Glu Ala Gln Gln Asn Lys Lys Ser Ser Gly Phe
             355                 360                 365

 ctt tca aat ctg ctg gga ggc cat taatctagga atcagcttgc aacagagcac    1699
 Leu Ser Asn Leu Leu Gly Gly His 
         370                 375

 aaaaaa                                                              1705




      <210> 164
      <211> 1782
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (22)..(1458)

      <400> 164
 caccgcgttc tcgcacgcgt c  atg gcg gtc ctc gga gta cag ctg gtg gtg      51
                          Met Ala Val Leu Gly Val Gln Leu Val Val
                            1               5                  10

 acc ctg ctc act gcc acc ctc atg cac agg ctg gcg cca cac tgc tcc       99
 Thr Leu Leu Thr Ala Thr Leu Met His Arg Leu Ala Pro His Cys Ser
                  15                  20                  25

 ttc gcg cgc tgg ctg ctc tgt aac ggc agt ttg ttc cga tac aag cac      147
 Phe Ala Arg Trp Leu Leu Cys Asn Gly Ser Leu Phe Arg Tyr Lys His
              30                  35                  40

 ccg tct gag gag gag ctt cgg gcc ctg gcg ggg aag ccg agg ccc aga      195
 Pro Ser Glu Glu Glu Leu Arg Ala Leu Ala Gly Lys Pro Arg Pro Arg
          45                  50                  55

 ggc agg aaa gag cgg tgg gcc aat ggc ctt agt gag gag aag cca ctg      243
 Gly Arg Lys Glu Arg Trp Ala Asn Gly Leu Ser Glu Glu Lys Pro Leu
      60                  65                  70

 tct gtg ccc cga gat gcc ccg ttc cag ctg gag acc tgc ccc ctc acg      291
 Ser Val Pro Arg Asp Ala Pro Phe Gln Leu Glu Thr Cys Pro Leu Thr
  75                  80                  85                  90

 acc gtg gat gcc ctg gtc ctg cgc ttc ttc ctg gag tac cag tgg ttt      339
 Thr Val Asp Ala Leu Val Leu Arg Phe Phe Leu Glu Tyr Gln Trp Phe
                  95                 100                 105

 gtg gac ttt gct gtg tac tcg ggc ggc gtg tac ctc ttc aca gag gcc      387
 Val Asp Phe Ala Val Tyr Ser Gly Gly Val Tyr Leu Phe Thr Glu Ala
             110                 115                 120

 tac tac tac atg ctg gga cca gcc aag gag act aac att gct gtg ttc      435
 Tyr Tyr Tyr Met Leu Gly Pro Ala Lys Glu Thr Asn Ile Ala Val Phe
         125                 130                 135

 tgg tgc ctg ctc acg gtg acc ttc tcc atc aag atg ttc ctg aca gtg      483
 Trp Cys Leu Leu Thr Val Thr Phe Ser Ile Lys Met Phe Leu Thr Val
     140                 145                 150

 aca cgg ctg tac ttc agc gcc gag gag ggg ggt gag cgc tct gtc tgc      531
 Thr Arg Leu Tyr Phe Ser Ala Glu Glu Gly Gly Glu Arg Ser Val Cys
 155                 160                 165                 170

 ctc acc ttt gcc ttc ctc ttc ctg ctg ctg gcc atg ctg gtg caa gtg      579
 Leu Thr Phe Ala Phe Leu Phe Leu Leu Leu Ala Met Leu Val Gln Val
                 175                 180                 185

 gtg cgg gag gag acc ctc gag ctg ggc ctg gag cct ggt ctg gcc agc      627
 Val Arg Glu Glu Thr Leu Glu Leu Gly Leu Glu Pro Gly Leu Ala Ser
             190                 195                 200

 atg acc cag aac tta gag cca ctt ctg aag aag cag ggc tgg gac tgg      675
 Met Thr Gln Asn Leu Glu Pro Leu Leu Lys Lys Gln Gly Trp Asp Trp
         205                 210                 215

 gcg ctt cct gtg gcc aag ctg gct atc cgc gtg gga ctg gca gtg gtg      723
 Ala Leu Pro Val Ala Lys Leu Ala Ile Arg Val Gly Leu Ala Val Val
     220                 225                 230

 ggc tct gtg ctg ggt gcc ttc ctc acc ttc cca ggc ctg cgg ctg gcc      771
 Gly Ser Val Leu Gly Ala Phe Leu Thr Phe Pro Gly Leu Arg Leu Ala
 235                 240                 245                 250

 cag acc cac cgg gac gca ctg acc atg tcg gag gac aga ccc atg ctg      819
 Gln Thr His Arg Asp Ala Leu Thr Met Ser Glu Asp Arg Pro Met Leu
                 255                 260                 265

 cag ttc ctc ctg cac acc agc ttc ctg tct ccc ctg ttc atc ctg tgg      867
 Gln Phe Leu Leu His Thr Ser Phe Leu Ser Pro Leu Phe Ile Leu Trp
             270                 275                 280

 ctc tgg aca aag ccc att gca cgg gac ttc ctg cac cag ccg ccg ttt      915
 Leu Trp Thr Lys Pro Ile Ala Arg Asp Phe Leu His Gln Pro Pro Phe
         285                 290                 295

 ggg gag acg cgt ttc tcc ctg ctg tcc gat tct gcc ttc gac tct ggg      963
 Gly Glu Thr Arg Phe Ser Leu Leu Ser Asp Ser Ala Phe Asp Ser Gly
     300                 305                 310

 cgc ctc tgg ttg ctg gtg gtg ctg tgc ctg ctg cgg ctg gcg gtg acc     1011
 Arg Leu Trp Leu Leu Val Val Leu Cys Leu Leu Arg Leu Ala Val Thr
 315                 320                 325                 330

 cgg ccc cac ctg cag gcc tac ctg tgc ctg gcc aag gcc cgg gtg gag     1059
 Arg Pro His Leu Gln Ala Tyr Leu Cys Leu Ala Lys Ala Arg Val Glu
                 335                 340                 345

 cag ctg cga agg gag gct ggc cgc atc gaa gcc cgt gaa atc cag cag     1107
 Gln Leu Arg Arg Glu Ala Gly Arg Ile Glu Ala Arg Glu Ile Gln Gln
             350                 355                 360

 agg gtg gtc cga gtc tac tgc tat gtg acc gtg gtg agc ttg cag tac     1155
 Arg Val Val Arg Val Tyr Cys Tyr Val Thr Val Val Ser Leu Gln Tyr
         365                 370                 375

 ctg acg ccg ctc atc ctc acc ctc aac tgc aca ctt ctg ctc aag acg     1203
 Leu Thr Pro Leu Ile Leu Thr Leu Asn Cys Thr Leu Leu Leu Lys Thr
     380                 385                 390

 ctg gga ggc tat tcc tgg ggc ctg ggc cca gct cct cta cta tcc ccc     1251
 Leu Gly Gly Tyr Ser Trp Gly Leu Gly Pro Ala Pro Leu Leu Ser Pro
 395                 400                 405                 410

 gac cca tcc tca gcc agc gct gcc ccc atc ggc tct ggg gag gac gaa     1299
 Asp Pro Ser Ser Ala Ser Ala Ala Pro Ile Gly Ser Gly Glu Asp Glu
                 415                 420                 425

 gtc cag cag act gca gcg cgg att gcc ggg gct ctg ggt ggc ctg ctt     1347
 Val Gln Gln Thr Ala Ala Arg Ile Ala Gly Ala Leu Gly Gly Leu Leu
             430                 435                 440

 act ccc ctc ttc ctc cgt ggc gtc ctg gcc tac ctc atc tgg tgg acg     1395
 Thr Pro Leu Phe Leu Arg Gly Val Leu Ala Tyr Leu Ile Trp Trp Thr
         445                 450                 455

 gct gcc tgc cag ctg ctc gcc agc ctt ttc ggc ctc tac ttc cac cag     1443
 Ala Ala Cys Gln Leu Leu Ala Ser Leu Phe Gly Leu Tyr Phe His Gln
     460                 465                 470

 cac ttg gca ggc tcc tagctgcctg cagaccctcc tggggccctg aggtctgttc     1498
 His Leu Ala Gly Ser 
 475

 ctggggcagc gggacactag cctgccccct ctgtttgcgc ccccgtgtcc ccagctgcaa   1558

 ggtggggccg gactccccgg cgttcccttc accacagtgc ctgacccgcg gccccccttg   1618

 gacgccgagt ttctgcctca gaactgtctc tcctgggccc agcagcatga gggtcccgag   1678

 gccattgtct ccgaagcgta tgtgccaggt ttgagtggcg agggtgatgc tggctgctct   1738

 tctgaacaaa taaaggagca tgccgatttt tacaaaaaaa aaaa                    1782




      <210> 165
      <211> 824
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (26)..(757)

      <400> 165
 aggaggtccc ccacggccct tcagg  atg aaa gct gcg gtg ctg acc ttg gcc      52
                              Met Lys Ala Ala Val Leu Thr Leu Ala
                                1               5

 gtg ctc ttc ctg acg ggg agc cag gct cgg cat ttc tgg cag caa gat      100
 Val Leu Phe Leu Thr Gly Ser Gln Ala Arg His Phe Trp Gln Gln Asp
  10                  15                  20                  25

 gaa ccc ccc cag agc ccc tgg gat cga gtg aag gac ctg gcc act gtg      148
 Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr Val
                  30                  35                  40

 tac gtg gat gtg ctc aaa gac agc ggc aaa gac agc gtg acc tcc acc      196
 Tyr Val Asp Val Leu Lys Asp Ser Gly Lys Asp Ser Val Thr Ser Thr
              45                  50                  55

 ttc agc aag ctg cgc gaa cag ctc ggc cct gtg acc cag gag ttc tgg      244
 Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp
          60                  65                  70

 gat aac ctg gaa aag gag aca gag ggc ctg agg cag gag atg agc aag      292
 Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys
      75                  80                  85

 gat ctg gag gag gtg aag gcc aag gtg cag ccc tac ctg gac gac ttc      340
 Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe
  90                  95                 100                 105

 cag aag aag tgg cag gag gag atg gag ctc tac cgc cag aag gtg gag      388
 Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu
                 110                 115                 120

 ccg ctg cgc gca gag ctc caa gag ggc gcg cgc cag aag ctg cac gag      436
 Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu
             125                 130                 135

 ctg caa gag aag ctg agc cca ctg ggc gag gag atg cgc gac cgc gcg      484
 Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala
         140                 145                 150

 cgc gcc cat gtg gac gcg ctg cgc acg cat ctg gcc ccc tac agc gac      532
 Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp
     155                 160                 165

 gag ctg cgc cag cgc ttg gcc gcg cgc ctt gag gct ctc aag gag aac      580
 Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn
 170                 175                 180                 185

 ggc ggc gcc aga ctg gcc gag tac cac gcc aag gcc acc gag cat ctg      628
 Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu
                 190                 195                 200

 agc acg ctc agc gag aag gcc aag ccc gcg ctc gag gac ctc cgc caa      676
 Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln
             205                 210                 215

 ggc ctg ctg ccc gtg ctg gag agc ttc aag gtc agc ttc ctg agc gct      724
 Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala
         220                 225                 230

 ctc gag gag tac act aag aag ctc aac acc cag tgaggcgc ccgccgccgc      775
 Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
     235                 240

 cccccttccc ggtgctcaga ataaacgttt ccaaagtggg aaaaaaaaa                824




      <210> 166
      <211> 2454
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (154)..(1707)

      <400> 166
 gtgaaaggag ggaacgcagg tgagaaagcg agacaggcag gtagggaaat cgtgaggtga     60

 gcgtgatcct agctccttgt ggcagagcct agagagaagg cgaggacgct gaagaaccag    120

 gcggacagct ggcagagaga gaagttggct agc atg gaa tca cca gag gag cct     174
                                      Met Glu Ser Pro Glu Glu Pro
                                        1               5

 gga gca tcc atg gat gag aac tac ttt gtg aac tac act ttc aaa gat      222
 Gly Ala Ser Met Asp Glu Asn Tyr Phe Val Asn Tyr Thr Phe Lys Asp
          10                  15                  20

 cgg tca cat tca ggc cgt gtg gct caa ggc atc atg aaa ctg tgt cta      270
 Arg Ser His Ser Gly Arg Val Ala Gln Gly Ile Met Lys Leu Cys Leu
      25                  30                  35

 gag gag gag ctc ttt gct gat gtc acc att tcg gtg gaa ggc cgg gag      318
 Glu Glu Glu Leu Phe Ala Asp Val Thr Ile Ser Val Glu Gly Arg Glu
  40                  45                  50                  55

 ttt cag ctc cat cgg ctg gtc ctc tca gct cag agc tgc ttc ttc cga      366
 Phe Gln Leu His Arg Leu Val Leu Ser Ala Gln Ser Cys Phe Phe Arg
                  60                  65                  70

 tcc atg ttc act tcc aac ctg aag gag gcc cac aac cgg gtg att gtg      414
 Ser Met Phe Thr Ser Asn Leu Lys Glu Ala His Asn Arg Val Ile Val
              75                  80                  85

 ctg cag gat gtc agc gag tct gtt ttc cag ctc ctg gtt gat tat atc      462
 Leu Gln Asp Val Ser Glu Ser Val Phe Gln Leu Leu Val Asp Tyr Ile
          90                  95                 100

 tac cat ggg act gtg aaa ctt cga gct gag gag ttg cag gaa att tat      510
 Tyr His Gly Thr Val Lys Leu Arg Ala Glu Glu Leu Gln Glu Ile Tyr
     105                 110                 115

 gag gtg tca gac atg tat cag ctg aca tct ctc ttt gag gaa tgc tct      558
 Glu Val Ser Asp Met Tyr Gln Leu Thr Ser Leu Phe Glu Glu Cys Ser
 120                 125                 130                 135

 cgg ttt ttg gcc cgc aca gtg caa gtg gga aac tgc ctt cag gtg atg      606
 Arg Phe Leu Ala Arg Thr Val Gln Val Gly Asn Cys Leu Gln Val Met
                 140                 145                 150

 tgg ctg gca gat cgg cac agt gat cct gag ctc tat acg gct gcc aag      654
 Trp Leu Ala Asp Arg His Ser Asp Pro Glu Leu Tyr Thr Ala Ala Lys
             155                 160                 165

 cac tgt gcc aag acc cac ctg gcc cag ctg cag aat aca gag gaa ttt      702
 His Cys Ala Lys Thr His Leu Ala Gln Leu Gln Asn Thr Glu Glu Phe
         170                 175                 180

 ctc cac ttg ccc cac cgc tta ctc aca gat atc atc tcg gat gga gtt      750
 Leu His Leu Pro His Arg Leu Leu Thr Asp Ile Ile Ser Asp Gly Val
     185                 190                 195

 ccg tgt tct cag aac cca aca gag gca ata gaa gcc tgg atc aac ttt      798
 Pro Cys Ser Gln Asn Pro Thr Glu Ala Ile Glu Ala Trp Ile Asn Phe
 200                 205                 210                 215

 aat aaa gag gaa aga gag gct ttt gca gag tca ctc agg aca agc ttg      846
 Asn Lys Glu Glu Arg Glu Ala Phe Ala Glu Ser Leu Arg Thr Ser Leu
                 220                 225                 230

 aag gaa att ggg gag aat gtg cac att tac ctg att ggg aaa gag tca      894
 Lys Glu Ile Gly Glu Asn Val His Ile Tyr Leu Ile Gly Lys Glu Ser
             235                 240                 245

 tct cgt acc cac tcg ttg gct gtg tcc ttg cac tgt gca gaa gat gac      942
 Ser Arg Thr His Ser Leu Ala Val Ser Leu His Cys Ala Glu Asp Asp
         250                 255                 260

 tcc atc agt gta agt ggc caa aac agt ttg tgc cac cag atc act gcg      990
 Ser Ile Ser Val Ser Gly Gln Asn Ser Leu Cys His Gln Ile Thr Ala
     265                 270                 275

 gcc tgc aag cat ggt gga gac ttg tat gtg gtg gga ggg tcc atc cca     1038
 Ala Cys Lys His Gly Gly Asp Leu Tyr Val Val Gly Gly Ser Ile Pro
 280                 285                 290                 295

 cgg cgc atg tgg aag tgc aac aat gcc acc gtt gac tgg gag tgg tgt     1086
 Arg Arg Met Trp Lys Cys Asn Asn Ala Thr Val Asp Trp Glu Trp Cys
                 300                 305                 310

 gct cct ttg cct cgg gac cgg ctc cag cac acc ctg gtg tct gtg ccc     1134
 Ala Pro Leu Pro Arg Asp Arg Leu Gln His Thr Leu Val Ser Val Pro
             315                 320                 325

 ggg aaa gat gcc ata tat tca ctg ggt ggc aag aca ctg caa gat acc     1182
 Gly Lys Asp Ala Ile Tyr Ser Leu Gly Gly Lys Thr Leu Gln Asp Thr
         330                 335                 340

 ctc tcc aac gca gtc att tat tat cgc gta ggt gat aat gtg tgg aca     1230
 Leu Ser Asn Ala Val Ile Tyr Tyr Arg Val Gly Asp Asn Val Trp Thr
     345                 350                 355

 gag aca act cag cta gag gtg gct gtg tca ggg gct gct ggt gcc aac     1278
 Glu Thr Thr Gln Leu Glu Val Ala Val Ser Gly Ala Ala Gly Ala Asn
 360                 365                 370                 375

 ctc aac ggg atc atc tac tta cta ggg ggg gag gag aat gat ctg gac     1326
 Leu Asn Gly Ile Ile Tyr Leu Leu Gly Gly Glu Glu Asn Asp Leu Asp
                 380                 385                 390

 ttc ttt acc aaa cct tcc cga ctc atc cag tgc ttt gac aca gag aca     1374
 Phe Phe Thr Lys Pro Ser Arg Leu Ile Gln Cys Phe Asp Thr Glu Thr
             395                 400                 405

 gac aaa tgc cat gtg aag ccc tat gtg ctg ccc ttt gca ggc cgc atg     1422
 Asp Lys Cys His Val Lys Pro Tyr Val Leu Pro Phe Ala Gly Arg Met
         410                 415                 420

 cac gca gct gtg cat aaa gat ctg gtg ttc atc gtg gct gaa ggg gac     1470
 His Ala Ala Val His Lys Asp Leu Val Phe Ile Val Ala Glu Gly Asp
     425                 430                 435

 tcc ctg gtg tgc tac aat ccc ttg cta gac agc ttc acc cgg ctt tgc     1518
 Ser Leu Val Cys Tyr Asn Pro Leu Leu Asp Ser Phe Thr Arg Leu Cys
 440                 445                 450                 455

 ctt cct gag gcc tgg agc tct gcc cca tcc ctc tgg aag att gcc agc     1566
 Leu Pro Glu Ala Trp Ser Ser Ala Pro Ser Leu Trp Lys Ile Ala Ser
                 460                 465                 470

 tgt aac ggg agc atc tat gtc ttc cgg gac cga tat aaa aag ggg gat     1614
 Cys Asn Gly Ser Ile Tyr Val Phe Arg Asp Arg Tyr Lys Lys Gly Asp
             475                 480                 485

 gcc aac acc tac aag ctt gac cct gcc act tca gcc gta act gtc aca     1662
 Ala Asn Thr Tyr Lys Leu Asp Pro Ala Thr Ser Ala Val Thr Val Thr
         490                 495                 500

 aga ggt att aag gtg ctg ctt acc aat ttg cag ttt gtg ttg gcc taa     1710
 Arg Gly Ile Lys Val Leu Leu Thr Asn Leu Gln Phe Val Leu Ala 
     505                 510                 515

 ggctgtgggg aggggaggag aactgctcac tccttttccc tccccataca aactcaaagt   1770

 cccctgggcc ccaattcaga gttatgtttt ttttggcaca tactagaaag gcagtgcctc   1830

 agcccttccc tgaatccatg gaggtgttct gtttggggct ttttagactg ctgctgctca   1890

 gctggttgct tgaactgaca gtaggccagc ctgttctctg ccattcccta gtcatcctgt   1950

 gcctcaccac agcttgctta gagcaagcct tttctcagac cttaggcaca gcctctcctc   2010

 tttacctgat caatgttaaa tgtaagcacc cctgatccca ggacataagg aaagatgccc   2070

 aattgtactt ttgttctata gcctgtgaaa tggctagttg atcatttttc cacaaagaat   2130

 taggtgttaa gagttttcct tcaggcttta cttaggagaa tggactaagc tgaaggtgta   2190

 cttcaccagc aagagtcaac tctagaattc aggatgttcc ttctattgtt ttcttagcca   2250

 tctgtcagga aatgtaactt tggttttatt tttggcttat tccaaggggt aagccagaaa   2310

 atagaaatga ttatttctga ttaatagcag aaactttttc aatctcaaat atataaggtg   2370

 tctgctcttt taaaagctct aagctaagtc aagagctagg aactgttgat acaaataaaa   2430

 gtttttgaag ggaaaaaaaa aaaa                                          2454




      <210> 167
      <211> 3549
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (69)..(1820)

      <400> 167
 agcaggcaga cgtcgaagcc gtcctgcagc cgaccctcct gcatctgggc acgttcaggt     60

 tgcgacac atg aag gct ttg atg aac gag aag gcc cag gcc gcc ctg gtg     110
          Met Lys Ala Leu Met Asn Glu Lys Ala Gln Ala Ala Leu Val
            1               5                  10

 gag ttt gtg gag gac gtc aat cac gct gcc att ccc agg gag atc cca      158
 Glu Phe Val Glu Asp Val Asn His Ala Ala Ile Pro Arg Glu Ile Pro
  15                  20                  25                  30

 cgc aag gat ggg gtc tgg agg gtt ctg tgg aag gac cgt gcg cag gac      206
 Arg Lys Asp Gly Val Trp Arg Val Leu Trp Lys Asp Arg Ala Gln Asp
                  35                  40                  45

 acg agg gtc ctg agg cag atg aca cgc ctg ctg ctg gat gac ggg ccc      254
 Thr Arg Val Leu Arg Gln Met Thr Arg Leu Leu Leu Asp Asp Gly Pro
              50                  55                  60

 acg cag gcc gcg gag gct ggg acc ccc ggt gag gca ccc acc cct ccc      302
 Thr Gln Ala Ala Glu Ala Gly Thr Pro Gly Glu Ala Pro Thr Pro Pro
          65                  70                  75

 gct tcg gag acg cag gcc cag gat tct ggt gag gta aca ggg cat gct      350
 Ala Ser Glu Thr Gln Ala Gln Asp Ser Gly Glu Val Thr Gly His Ala
      80                  85                  90

 ggc tcg ctt ctt ggg gca ccc agg aac cca agg agg ggc cgt cgg ggt      398
 Gly Ser Leu Leu Gly Ala Pro Arg Asn Pro Arg Arg Gly Arg Arg Gly
  95                 100                 105                 110

 cgc aga aac aga acc aga cgc aac agg ttg acc cag aag ggc aag aag      446
 Arg Arg Asn Arg Thr Arg Arg Asn Arg Leu Thr Gln Lys Gly Lys Lys
                 115                 120                 125

 aga agc cga gga gga cgg ccg tct gct ccc gcg agg agt gag gcc gag      494
 Arg Ser Arg Gly Gly Arg Pro Ser Ala Pro Ala Arg Ser Glu Ala Glu
             130                 135                 140

 gac tct tcc gac gag agc ctg ggc atc gtg atc gag gag atc gac cag      542
 Asp Ser Ser Asp Glu Ser Leu Gly Ile Val Ile Glu Glu Ile Asp Gln
         145                 150                 155

 ggc gac ctg agc gga gaa gag gac cag agc gcg ctg tac gcc acg ctg      590
 Gly Asp Leu Ser Gly Glu Glu Asp Gln Ser Ala Leu Tyr Ala Thr Leu
     160                 165                 170

 cag gcc gct gcc agg gag ctg gtt agg cag tgg gcg ccc tgc aac tcc      638
 Gln Ala Ala Ala Arg Glu Leu Val Arg Gln Trp Ala Pro Cys Asn Ser
 175                 180                 185                 190

 gag ggg gaa gaa gac ggt ccc cgc gag ttc ttg gct ctg gtc acc gtc      686
 Glu Gly Glu Glu Asp Gly Pro Arg Glu Phe Leu Ala Leu Val Thr Val
                 195                 200                 205

 acc gac aaa tcg aag aaa gaa gag gca gag aag gag cca gct ggg gcc      734
 Thr Asp Lys Ser Lys Lys Glu Glu Ala Glu Lys Glu Pro Ala Gly Ala
             210                 215                 220

 gaa tcc atc cgc ttg aac acc aaa gaa gac aaa aat ggt gtc ccc gac      782
 Glu Ser Ile Arg Leu Asn Thr Lys Glu Asp Lys Asn Gly Val Pro Asp
         225                 230                 235

 tta gtg gcc ctg ctg gct gtg aga gac acc ccg gac gag gag ccg gtg      830
 Leu Val Ala Leu Leu Ala Val Arg Asp Thr Pro Asp Glu Glu Pro Val
     240                 245                 250

 gac agc gac act tcg gag agc gac tcg cag gaa agt ggg gac caa gaa      878
 Asp Ser Asp Thr Ser Glu Ser Asp Ser Gln Glu Ser Gly Asp Gln Glu
 255                 260                 265                 270

 aca gag gag ttg gat aat cct gag ttc gtg gcc att gtg gcc tat acc      926
 Thr Glu Glu Leu Asp Asn Pro Glu Phe Val Ala Ile Val Ala Tyr Thr
                 275                 280                 285

 gac ccg tcg gac ccc tgg gcc cgg gag gag atg ttg aaa atc gct tct      974
 Asp Pro Ser Asp Pro Trp Ala Arg Glu Glu Met Leu Lys Ile Ala Ser
             290                 295                 300

 gtt atc gag tcg ctg ggc tgg agc gac gag aaa gac aag cga gac ccc     1022
 Val Ile Glu Ser Leu Gly Trp Ser Asp Glu Lys Asp Lys Arg Asp Pro
         305                 310                 315

 ctc cga cag gtc ttg tcc gtc atg tcc aag gac act aac ggg acc cgc     1070
 Leu Arg Gln Val Leu Ser Val Met Ser Lys Asp Thr Asn Gly Thr Arg
     320                 325                 330

 gtg aag gtg gaa gag gcg ggc cgc gag gtg gac gcc gtg gtc ctg cgc     1118
 Val Lys Val Glu Glu Ala Gly Arg Glu Val Asp Ala Val Val Leu Arg
 335                 340                 345                 350

 aag gcc ggg gat gac ggg gac ctc cgg gag tgc att tcc acc ttg gcg     1166
 Lys Ala Gly Asp Asp Gly Asp Leu Arg Glu Cys Ile Ser Thr Leu Ala
                 355                 360                 365

 cag ccg gat ctc cct ccc cag gcg aag aag gct ggg cgt ggc ctc ttc     1214
 Gln Pro Asp Leu Pro Pro Gln Ala Lys Lys Ala Gly Arg Gly Leu Phe
             370                 375                 380

 ggg ggc tgg agc gag cac cgt gag gac gaa ggg ggt ctt ctg gag ctg     1262
 Gly Gly Trp Ser Glu His Arg Glu Asp Glu Gly Gly Leu Leu Glu Leu
         385                 390                 395

 gtg gcg ctc ctg gct gcc cag gac atg gcg gag gtg atg aag gag gaa     1310
 Val Ala Leu Leu Ala Ala Gln Asp Met Ala Glu Val Met Lys Glu Glu
     400                 405                 410

 aaa gaa aac gcc tgg gaa ggc ggg aag tac aaa tac ccc aaa ggc aaa     1358
 Lys Glu Asn Ala Trp Glu Gly Gly Lys Tyr Lys Tyr Pro Lys Gly Lys
 415                 420                 425                 430

 ctg ggg gag gta ttg gcg ctc ctg gcc gcc cgg gag aac atg ggg tcc     1406
 Leu Gly Glu Val Leu Ala Leu Leu Ala Ala Arg Glu Asn Met Gly Ser
                 435                 440                 445

 aac gag ggg tcg gag gag gct tcg gac gaa cag tcc gag gag gag tcg     1454
 Asn Glu Gly Ser Glu Glu Ala Ser Asp Glu Gln Ser Glu Glu Glu Ser
             450                 455                 460

 gag gac acc gag agc gag gcg tcg gag ccg gag gac agg gca tcc agg     1502
 Glu Asp Thr Glu Ser Glu Ala Ser Glu Pro Glu Asp Arg Ala Ser Arg
         465                 470                 475

 aag ccc cgg gcc aag agg gcg cgc acg gcc ccc agg ggc ctg act ccg     1550
 Lys Pro Arg Ala Lys Arg Ala Arg Thr Ala Pro Arg Gly Leu Thr Pro
     480                 485                 490

 gcc ggc gcg cct ccc acc gct tcc ggg gcc cgc aaa acc cgc gcg ggc     1598
 Ala Gly Ala Pro Pro Thr Ala Ser Gly Ala Arg Lys Thr Arg Ala Gly
 495                 500                 505                 510

 ggc cga ggc cga ggc cga ggc cgg ggc gtc act ccc gag aag aaa gcc     1646
 Gly Arg Gly Arg Gly Arg Gly Arg Gly Val Thr Pro Glu Lys Lys Ala
                 515                 520                 525

 ggg agc cgg ggc tcg gcc cag gac gac gcc gca gga agc agg aag aag     1694
 Gly Ser Arg Gly Ser Ala Gln Asp Asp Ala Ala Gly Ser Arg Lys Lys
             530                 535                 540

 aag ggg agc gcg ggc tcc ggg gcc cat gcc agg gca ggc gag gcc aag     1742
 Lys Gly Ser Ala Gly Ser Gly Ala His Ala Arg Ala Gly Glu Ala Lys
         545                 550                 555

 ggc cag gcg ccc act gga tcc aag gcc gcg cgc ggg aag aag gcc cgt     1790
 Gly Gln Ala Pro Thr Gly Ser Lys Ala Ala Arg Gly Lys Lys Ala Arg
     560                 565                 570

 cgg ggc cgg agg ctg ccc cct aaa tgc cgc t agtggccccc caagaagccg     1841
 Arg Gly Arg Arg Leu Pro Pro Lys Cys Arg 
 575                 580

 cccaggctgc gagcaggccc cgcagggcac ccgcccgcct gtggcccccg ccctcccctc   1901

 ccctcttcct gtcctccgca gacgcaatct cctcgcttca cagcgcgccc gggccgcgtt   1961

 ttgccagcgt cacgttcccc tctcgggccc tcgcaggccg ggggcgccag cgatcccgac   2021

 ggaggaagcc cggatgggag gaggaaagag aagtgggcgc ccgaggcagc agcgcagggc   2081

 cgagatgggg acgcgccaag tggaccagga ttgggggccc gggttgcccc cggagggggt   2141

 gtgtgtgtgg acgccgggca cctgcagagg cgagcagggc tcttcgtggc gctctcgggg   2201

 cctgcgcctg gcaggtgctg taggccgctg tcgcccctac cccagtctga ctgggccctg   2261

 ggtctgtggt ggaggctcag tcaccagccg cgcagcgcgt gtcagggcgc aactctcagc   2321

 caggggaggc cccagctccc agccagggga agagatgatt ccagaaagga aagtctgaga   2381

 gatagaaggc ggttgggaag gggaggagga ggaaagggga gaggaacggt gggagaaggg   2441

 aaagaggagg aggaggggga ggggggagca gagggaagac acatgccagc cctgcctact   2501

 ggggcgcccc tgataacaaa ggaaccagcc ccaggccaag gccacctgcc cctgaccaca   2561

 agttgaattt gtcactcaga ctgcagtgtt tcccaacatt ctaattattt gcagaggtgt   2621

 tcaatttggg gtaattcact taaaatccag ttttggttct tctgggctga gtgggccctg   2681

 gcccctccca taggctgtgg ctcccctggg tgccccctct ccagtggagc tgacccaccg   2741

 ctcagcgctg gccttgcagc ccttactaaa agacttgaaa gtccctgggt tcaccccctg   2801

 agtgaattaa aggccagagg ggccccgaag ggcactgtga gggacagagg ctcacctggg   2861

 cagtgcagaa gccggccgcg tgtccctcct tacaggggat gaaatgacct ggggaggaaa   2921

 ccccagccct gccctggagg ttccagagta ggcgggccgg tgctgtgagg cttcacaacc   2981

 tgctgtccca agcacgcttg agttgtatgt gagtctgtgc cgtgccgtgc cgtatgcttc   3041

 agctcctgca accccggctg agctcgattt ttacctaaat atcagtctcc acgggacccc   3101

 accttcattc atgccttctt gtccctgggg caatgtgtgt gcttcctcgt cccaatttcc   3161

 attccctggc agtgaggagc ccatcgtgcc agggggccct gccccacttg tccctgggaa   3221

 ggaataggag ggtttgggtg tgacctcaca gtccagacca gactgtccca gtcctatgtc   3281

 agggacaccc agatgtagaa gctgactgag acctgctgca gggcgtgggt gctcccctct   3341

 gcttggaggc tgtccctgga cagtgaccca cccactgagg accaggctgg gtgtaccttg   3401

 agctgggcac agcagcctgt ggtgttgcct gtgggtgggg agggccccag gtgtgcttct   3461

 cccgtagcag tcctaggctt ctctccctgt gccctgtgtc acctggatcc tccagtaaag   3521

 tgaaattcag cactgtaaaa aaaaaaaa                                      3549




      <210> 168
      <211> 3340
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (47)..(1891)

      <400> 168
 gatacagttc tgaccatcat tacgccaatc ttggcacgag gggaag   atg gcg gag      55
                                                      Met Ala Glu
                                                        1

 tcc ggc ggt agc agc ggt ggt gct ggt ggc ggc ggc gct ttc ggc gcg      103
 Ser Gly Gly Ser Ser Gly Gly Ala Gly Gly Gly Gly Ala Phe Gly Ala
       5                  10                  15

 ggc ccg ggc ccc gag cgc ccg aac agc acg gcc gac aag aac ggg gcc      151
 Gly Pro Gly Pro Glu Arg Pro Asn Ser Thr Ala Asp Lys Asn Gly Ala
  20                  25                  30                  35

 ctc aag tgc acc ttc tcg gca ccc agc cac agc acc agc ctc ctg cag      199
 Leu Lys Cys Thr Phe Ser Ala Pro Ser His Ser Thr Ser Leu Leu Gln
                  40                  45                  50

 ggc ctg gcc acc ctc cgc gct cag ggc cag ctc ctc gat gtt gtg ctg      247
 Gly Leu Ala Thr Leu Arg Ala Gln Gly Gln Leu Leu Asp Val Val Leu
              55                  60                  65

 act att aac aga gag gcc ttt cct gca cac aag gtc gtc ctg gct gcc      295
 Thr Ile Asn Arg Glu Ala Phe Pro Ala His Lys Val Val Leu Ala Ala
          70                  75                  80

 tgc agc gac tac ttc agg gcc atg ttc acc ggc ggc atg cgg gag gca      343
 Cys Ser Asp Tyr Phe Arg Ala Met Phe Thr Gly Gly Met Arg Glu Ala
      85                  90                  95

 agc cag gac gtc atc gag ctg aag ggc gtg tcg gcc cgt ggc ctg cgg      391
 Ser Gln Asp Val Ile Glu Leu Lys Gly Val Ser Ala Arg Gly Leu Arg
 100                 105                 110                 115

 cac atc atc gac ttc gcc tac agc gcc gag gtg aca ctg gac ctg gac      439
 His Ile Ile Asp Phe Ala Tyr Ser Ala Glu Val Thr Leu Asp Leu Asp
                 120                 125                 130

 tgc gtg cag gac gtg ctg ggc gcg gcc gtg ttc ttg cag atg ctg ccc      487
 Cys Val Gln Asp Val Leu Gly Ala Ala Val Phe Leu Gln Met Leu Pro
             135                 140                 145

 gtg gtg gag ctg tgc gag gag ttc ctg aag gcg gcc atg agc gtg gag      535
 Val Val Glu Leu Cys Glu Glu Phe Leu Lys Ala Ala Met Ser Val Glu
         150                 155                 160

 acc tgc ctc aac atc ggc cag atg gcc acc acc ttc agc ctg gcc tcg      583
 Thr Cys Leu Asn Ile Gly Gln Met Ala Thr Thr Phe Ser Leu Ala Ser
     165                 170                 175

 ctg cga gag tcg gtg gat gcc ttc acc ttc cgg cac ttc ctg cag atc      631
 Leu Arg Glu Ser Val Asp Ala Phe Thr Phe Arg His Phe Leu Gln Ile
 180                 185                 190                 195

 gcc gag gag gag gat ttc ctg cgc ctg cca ctg gag cgc ctg gtc ttc      679
 Ala Glu Glu Glu Asp Phe Leu Arg Leu Pro Leu Glu Arg Leu Val Phe
                 200                 205                 210

 ttc ctg cag agc aac cgg ctg cag agc tgt gcc gag atc gac ctg ttc      727
 Phe Leu Gln Ser Asn Arg Leu Gln Ser Cys Ala Glu Ile Asp Leu Phe
             215                 220                 225

 cgc gcg gcc gtc cgc tgg ctg cag cat gac ccg gcc cgg cgg ccg cgc      775
 Arg Ala Ala Val Arg Trp Leu Gln His Asp Pro Ala Arg Arg Pro Arg
         230                 235                 240

 gcc agc cac gtg ctc tgc cac att cgc ttc ccg ctc atg cag tcg tcc      823
 Ala Ser His Val Leu Cys His Ile Arg Phe Pro Leu Met Gln Ser Ser
     245                 250                 255

 gag ctg gtg gac agc gtg cag acg ctg gac atc atg gtg gag gac gtg      871
 Glu Leu Val Asp Ser Val Gln Thr Leu Asp Ile Met Val Glu Asp Val
 260                 265                 270                 275

 ctg tgc cgc cag tat ctg ctg gag gcc ttc aac tac cag gtg ctg ccc      919
 Leu Cys Arg Gln Tyr Leu Leu Glu Ala Phe Asn Tyr Gln Val Leu Pro
                 280                 285                 290

 ttc cgg cag cac gag atg cag tct ccg cgc acc gcc gtg cgc tcg gat      967
 Phe Arg Gln His Glu Met Gln Ser Pro Arg Thr Ala Val Arg Ser Asp
             295                 300                 305

 gtg ccc tcg ctc gtc acc ttc ggc ggc acg ccc tac acc gac agc gac     1015
 Val Pro Ser Leu Val Thr Phe Gly Gly Thr Pro Tyr Thr Asp Ser Asp
         310                 315                 320

 cgc tcg gtc agc agc aag gtc tac cag ctg cct gag ccg gga gcc cgc     1063
 Arg Ser Val Ser Ser Lys Val Tyr Gln Leu Pro Glu Pro Gly Ala Arg
     325                 330                 335

 cac ttc cgc gag ctc acg gag atg gag gta ggc tgc agc cac acg tgc     1111
 His Phe Arg Glu Leu Thr Glu Met Glu Val Gly Cys Ser His Thr Cys
 340                 345                 350                 355

 gtg gcc gtg ctg gac aat ttt gtg tac gtg gcc ggg ggg cag cac ctg     1159
 Val Ala Val Leu Asp Asn Phe Val Tyr Val Ala Gly Gly Gln His Leu
                 360                 365                 370

 cag tac cgc agc ggc gag ggc gca gtg gac gcc tgc tac cgc tac gac     1207
 Gln Tyr Arg Ser Gly Glu Gly Ala Val Asp Ala Cys Tyr Arg Tyr Asp
             375                 380                 385

 ccc cac ctg aat cgc tgg ctg cgc ctg cag gcc atg cag gaa agc cgc     1255
 Pro His Leu Asn Arg Trp Leu Arg Leu Gln Ala Met Gln Glu Ser Arg
         390                 395                 400

 atc cag ttc cag ctg aac gtg ctg tgc ggc atg gtg tac gcc acg ggc     1303
 Ile Gln Phe Gln Leu Asn Val Leu Cys Gly Met Val Tyr Ala Thr Gly
     405                 410                 415

 ggc cgc aac cga gcc ggc agc ctg gcc tcc gtg gag cgg tac tgc ccc     1351
 Gly Arg Asn Arg Ala Gly Ser Leu Ala Ser Val Glu Arg Tyr Cys Pro
 420                 425                 430                 435

 cgg cgc aat gag tgg ggc tac gcc tgc tcg ctg aag cgc cgt acc tgg     1399
 Arg Arg Asn Glu Trp Gly Tyr Ala Cys Ser Leu Lys Arg Arg Thr Trp
                 440                 445                 450

 ggc cat gct ggg gcc gcc tca ggg ggc cgc ctc tac atc tcg ggt ggc     1447
 Gly His Ala Gly Ala Ala Ser Gly Gly Arg Leu Tyr Ile Ser Gly Gly
             455                 460                 465

 tac ggg atc tca gtg gag gac aag aag gcc ctg cac tgc tac gac ccc     1495
 Tyr Gly Ile Ser Val Glu Asp Lys Lys Ala Leu His Cys Tyr Asp Pro
         470                 475                 480

 gtg gcc gac cag tgg gag ttc aag gcg ccc atg agc gaa ccc cgc gtg     1543
 Val Ala Asp Gln Trp Glu Phe Lys Ala Pro Met Ser Glu Pro Arg Val
     485                 490                 495

 cta cac gcc atg gtg ggt gcc ggc ggc cgc atc tat gcc ctc ggg ggc     1591
 Leu His Ala Met Val Gly Ala Gly Gly Arg Ile Tyr Ala Leu Gly Gly
 500                 505                 510                 515

 cgc atg gac cac gcg gac cgc tgc ttc gac gtg ctg gct gtg gag tac     1639
 Arg Met Asp His Ala Asp Arg Cys Phe Asp Val Leu Ala Val Glu Tyr
                 520                 525                 530

 tat gtg ccg gag acg gac cag tgg acc agc gtg agc ccc atg cgg gcc     1687
 Tyr Val Pro Glu Thr Asp Gln Trp Thr Ser Val Ser Pro Met Arg Ala
             535                 540                 545

 ggc cag tca gag gcc ggc tgc tgc ctg ctg gag agg aag atc tac atc     1735
 Gly Gln Ser Glu Ala Gly Cys Cys Leu Leu Glu Arg Lys Ile Tyr Ile
         550                 555                 560

 gtc ggg ggc tac aac tgg cgt ctc aac aac gtc acg ggc atc gta cag     1783
 Val Gly Gly Tyr Asn Trp Arg Leu Asn Asn Val Thr Gly Ile Val Gln
     565                 570                 575

 gtg tac aac acg gac acc gac gag tgg gag cgg gac ctg cac ttc ccg     1831
 Val Tyr Asn Thr Asp Thr Asp Glu Trp Glu Arg Asp Leu His Phe Pro
 580                 585                 590                 595

 gag tcc ttc gca ggc ata gcc tgc gcc ccc gtc ctg ctg ccc cgg gcc     1879
 Glu Ser Phe Ala Gly Ile Ala Cys Ala Pro Val Leu Leu Pro Arg Ala
                 600                 605                 610

 ggg acc agg agg tag cccccaagac ccccgggacc ctggcctgac cgcatgttgt     1934
 Gly Thr Arg Arg 
             615

 ctccaagtgg ggcttggcga atgcacgtct gcctgagaac cccagtgccc cccttcgccc   1994

 gggctgccct tgaggggcct gctgcgttga taagcccccc tcccaggggt ccctccctcc   2054

 ctccttccca aagcagatcc tggctgcgag tccatccgag ggagcctgcc ggcaaagcgt   2114

 ctgacatgtg gtggcagcaa attcgtcccc ggggtggttt cctcgcctgg cccccgagtc   2174

 cccacgggct ggcgggtgga atcccaggtc tccagggggt ccctgtgcag ctccatctca   2234

 cttctctact gcctcccagc cccacggttt caggcattca gatgtgagct catcaacatt   2294

 gaacccaaag tcggtggtat atgactcacc ctccttccaa gtctcctgcg cgcgtgtttt   2354

 taaaataaac tcacccgaaa cgtccgtaac acacggacct ccaggagcag tgagaggtgg   2414

 cttagaagcc cctggtttgg ggtgggtgga ggaggagggc acgtgtctgc ctcccctggg   2474

 gtgccctcct tcccccatcc caagctgctg aggggaggcc ctggtcatgc ctcagttcct   2534

 gccttcatct gctttccgga ggaaaaacca tatcaactcc tagaaacgct ccttaggggc   2594

 ttgggacctt ccatttggca ctgagcatct tgtggggcct taactggctg agacatcccg   2654

 gccctctaca tttgccctgt tggccaggca gtccccttcc cgcaattgga gggcgacgct   2714

 aacttcagaa tcccatagtg gcgcttgccg caggtctggt ggggtgtctt ttttctcctc   2774

 cctcctttcc acccctccgc gccctgccac tccctggcct gccctgtttt tgggtcaaca   2834

 ttgctacgga gccagcagtg aggcctttcc cttcaagggc tctgtggtat ctctggccac   2894

 atttgttcta atgtctgaac ctctaaatct tttctttttg attggtttta ctgtttttaa   2954

 gaagccagca ctgctgtctc atagatggga tttgtactct tggggcaact taaagtgtct   3014

 ctctcgctgc taacagacga ttgatgtctt gtctctgtga cccactcacc atgtaaagaa   3074

 ttaacctcct atcttagcag acatcgtctc ctaatatttc cctttattta ataaaaatgt   3134

 tatggtgaag agatggagcc ggcccagcac tgagcttgtg cggcttgggt ctgattggtc   3194

 acagattcct cgtgtgtcct ccgcgtgtct gggggctcct ctcccccgcc tcagcctccc   3254

 cccgcatccc cccaagaaag gaaaattatt tttcgtattg taaactttaa acatgaaaaa   3314

 gctgttttta atttaaaaaa aaaaaa                                        3340




      <210> 169
      <211> 2547
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (143)..(2272)

      <400> 169
 aaggatcctt aattaaatta atcccccccc cccccccgcc cccgcggtgg cggcggcggc     60

 ggcggtggct gccgtggcgg ctgagagtcc agagccggac gttccggccg cttcgggctg    120

 gcggctggag agcgctcggg tc atg tct gcc cag ggg gac tgc gag ttc ctg     172
                          Met Ser Ala Gln Gly Asp Cys Glu Phe Leu
                            1               5                  10

 gtg cag cga gcc cgg gag ttg gtg ccg caa gac ctg tgg gca gcc aag      220
 Val Gln Arg Ala Arg Glu Leu Val Pro Gln Asp Leu Trp Ala Ala Lys
                  15                  20                  25

 gcg tgg ctg atc acg gcc cgc agc ctc tac ccg gca gac ttt aac atc      268
 Ala Trp Leu Ile Thr Ala Arg Ser Leu Tyr Pro Ala Asp Phe Asn Ile
              30                  35                  40

 cag tat gag atg tac acc atc gag cgg aat gca gag cgg acc gcc acc      316
 Gln Tyr Glu Met Tyr Thr Ile Glu Arg Asn Ala Glu Arg Thr Ala Thr
          45                  50                  55

 gcc ggg agg ctg ctg tac gac atg ttt gtg aat ttc cca gac cag ccg      364
 Ala Gly Arg Leu Leu Tyr Asp Met Phe Val Asn Phe Pro Asp Gln Pro
      60                  65                  70

 gtg gtg tgg aga gaa atc agc att att aca tca gca tta agg aac gat      412
 Val Val Trp Arg Glu Ile Ser Ile Ile Thr Ser Ala Leu Arg Asn Asp
  75                  80                  85                  90

 tca cag gac aaa caa acc caa ttt tta aga agt tta ttt gaa act ctt      460
 Ser Gln Asp Lys Gln Thr Gln Phe Leu Arg Ser Leu Phe Glu Thr Leu
                  95                 100                 105

 cct ggt cgg gtc cag tgt gaa atg tta cta aag gtc acg gaa caa tgc      508
 Pro Gly Arg Val Gln Cys Glu Met Leu Leu Lys Val Thr Glu Gln Cys
             110                 115                 120

 ttc aac acg tta gaa cga tca gaa atg ttg ctt cta ctt ttg agg cgc      556
 Phe Asn Thr Leu Glu Arg Ser Glu Met Leu Leu Leu Leu Leu Arg Arg
         125                 130                 135

 ttc cct gaa acg gtg gtg cag cat ggg gtt ggc ctt ggg gag gca cta      604
 Phe Pro Glu Thr Val Val Gln His Gly Val Gly Leu Gly Glu Ala Leu
     140                 145                 150

 tta gag gct gaa act att gaa gaa caa gaa tct cca gtg aac tgc ttt      652
 Leu Glu Ala Glu Thr Ile Glu Glu Gln Glu Ser Pro Val Asn Cys Phe
 155                 160                 165                 170

 aga aaa tta ttt gtt tgt gat gtc ctt cct cta ata att aac aac cat      700
 Arg Lys Leu Phe Val Cys Asp Val Leu Pro Leu Ile Ile Asn Asn His
                 175                 180                 185

 gat gtt cga tta cct gcc aat tta ttg tat aag tac ttg aac aaa gca      748
 Asp Val Arg Leu Pro Ala Asn Leu Leu Tyr Lys Tyr Leu Asn Lys Ala
             190                 195                 200

 gct gaa ttt tat atc aat tat gtc act agg tct act caa ata gaa aat      796
 Ala Glu Phe Tyr Ile Asn Tyr Val Thr Arg Ser Thr Gln Ile Glu Asn
         205                 210                 215

 cag cat caa ggc gcc cag gat aca tct gat tta atg tca cct agc aaa      844
 Gln His Gln Gly Ala Gln Asp Thr Ser Asp Leu Met Ser Pro Ser Lys
     220                 225                 230

 cgt agc tct cag aag tac ata ata gaa ggg ctg acg gaa aaa tca tcc      892
 Arg Ser Ser Gln Lys Tyr Ile Ile Glu Gly Leu Thr Glu Lys Ser Ser
 235                 240                 245                 250

 cag atc gtg gac cct tgg gag agg ttg ttt aag att ttg aat gtt gtt      940
 Gln Ile Val Asp Pro Trp Glu Arg Leu Phe Lys Ile Leu Asn Val Val
                 255                 260                 265

 gga atg aga tgt gaa tgg cag atg gat aaa gga aga cga agc tat gga      988
 Gly Met Arg Cys Glu Trp Gln Met Asp Lys Gly Arg Arg Ser Tyr Gly
             270                 275                 280

 gat att ttg cat aga atg aag gat ctc tgc aga tac atg aac aac ttt     1036
 Asp Ile Leu His Arg Met Lys Asp Leu Cys Arg Tyr Met Asn Asn Phe
         285                 290                 295

 gat agt gaa gca cat gca aaa tat aaa aac caa gtg gtg tat tcc acc     1084
 Asp Ser Glu Ala His Ala Lys Tyr Lys Asn Gln Val Val Tyr Ser Thr
     300                 305                 310

 atg ctg gtc ttc ttt aag aat gca ttc cag tat gtc aac agc ata cag     1132
 Met Leu Val Phe Phe Lys Asn Ala Phe Gln Tyr Val Asn Ser Ile Gln
 315                 320                 325                 330

 cca tct ctc ttc caa ggt cct aat gcc ccg agc caa gtt cca ctg gtt     1180
 Pro Ser Leu Phe Gln Gly Pro Asn Ala Pro Ser Gln Val Pro Leu Val
                 335                 340                 345

 ctt ctt gaa gat gta tcg aat gtg tat ggt gat gta gaa att gat cgt     1228
 Leu Leu Glu Asp Val Ser Asn Val Tyr Gly Asp Val Glu Ile Asp Arg
             350                 355                 360

 aat aaa cac atc cat aaa aag agg aaa cta gct gaa gga aga gaa aaa     1276
 Asn Lys His Ile His Lys Lys Arg Lys Leu Ala Glu Gly Arg Glu Lys
         365                 370                 375

 acc atg agt tca gac gat gaa gac tgt tcg gcg aaa gga aga aat cgt     1324
 Thr Met Ser Ser Asp Asp Glu Asp Cys Ser Ala Lys Gly Arg Asn Arg
     380                 385                 390

 cac att gta gtc aat aaa gcc gaa ctt gct aac tcc act gaa gtg tta     1372
 His Ile Val Val Asn Lys Ala Glu Leu Ala Asn Ser Thr Glu Val Leu
 395                 400                 405                 410

 gaa agc ttt aaa ttg gcc agg gag agc tgg gag ttg ctc tat tcc cta     1420
 Glu Ser Phe Lys Leu Ala Arg Glu Ser Trp Glu Leu Leu Tyr Ser Leu
                 415                 420                 425

 gaa ttc ctt gac aaa gaa ttt aca agg att tgc ttg gcc tgg aag acg     1468
 Glu Phe Leu Asp Lys Glu Phe Thr Arg Ile Cys Leu Ala Trp Lys Thr
             430                 435                 440

 gat act tgg ctt tgg tta aga atc ttc ctc act gat atg atc atc tat     1516
 Asp Thr Trp Leu Trp Leu Arg Ile Phe Leu Thr Asp Met Ile Ile Tyr
         445                 450                 455

 cag ggt caa tat aaa aag gcg ata gcc agc ctg cat cac tta gca gct     1564
 Gln Gly Gln Tyr Lys Lys Ala Ile Ala Ser Leu His His Leu Ala Ala
     460                 465                 470

 ctc cag gga tcc att tct cag cca cag atc aca ggg cag ggg acc ctg     1612
 Leu Gln Gly Ser Ile Ser Gln Pro Gln Ile Thr Gly Gln Gly Thr Leu
 475                 480                 485                 490

 gag cat cag agg gcg ctc atc cag ctg gcg acg tgc cac ttt gcg cta     1660
 Glu His Gln Arg Ala Leu Ile Gln Leu Ala Thr Cys His Phe Ala Leu
                 495                 500                 505

 ggg gag tac aga atg aca tgt gaa aaa gtc ctt gat ttg atg tgc tac     1708
 Gly Glu Tyr Arg Met Thr Cys Glu Lys Val Leu Asp Leu Met Cys Tyr
             510                 515                 520

 atg gta ctc ccc att caa gat gga ggc aaa tcc cag gag gaa ccc tcg     1756
 Met Val Leu Pro Ile Gln Asp Gly Gly Lys Ser Gln Glu Glu Pro Ser
         525                 530                 535

 aaa gta aag ccc aaa ttt aga aaa ggt tcg gat ctg aag ctc ctg cct     1804
 Lys Val Lys Pro Lys Phe Arg Lys Gly Ser Asp Leu Lys Leu Leu Pro
     540                 545                 550

 tgt acc agc aag gct atc atg cca tac tgc ctc cat tta atg tta gcc     1852
 Cys Thr Ser Lys Ala Ile Met Pro Tyr Cys Leu His Leu Met Leu Ala
 555                 560                 565                 570

 tgt ttt aag ctt aga gct ttc aca gac aac aga gac gac atg gca ttg     1900
 Cys Phe Lys Leu Arg Ala Phe Thr Asp Asn Arg Asp Asp Met Ala Leu
                 575                 580                 585

 ggg cat gtg att gtg ttg ctt cag caa gag tgg cca cgg ggc gag aat     1948
 Gly His Val Ile Val Leu Leu Gln Gln Glu Trp Pro Arg Gly Glu Asn
             590                 595                 600

 ctt ttc ctg aaa gct gtc aat aaa att tgc caa caa gga aat ttc caa     1996
 Leu Phe Leu Lys Ala Val Asn Lys Ile Cys Gln Gln Gly Asn Phe Gln
         605                 610                 615

 tat gag aat ttt ttc aat tac gtt aca aat att gat atg ctg gag gaa     2044
 Tyr Glu Asn Phe Phe Asn Tyr Val Thr Asn Ile Asp Met Leu Glu Glu
     620                 625                 630

 ttt gcc tac ttg aga act cag gaa ggt ggg aaa att cat ctg gaa tta     2092
 Phe Ala Tyr Leu Arg Thr Gln Glu Gly Gly Lys Ile His Leu Glu Leu
 635                 640                 645                 650

 cta ccc aat caa gga atg ctg atc aag cac cac act gta act cga ggc     2140
 Leu Pro Asn Gln Gly Met Leu Ile Lys His His Thr Val Thr Arg Gly
                 655                 660                 665

 atc acc aaa ggc gtg aag gag gac ttt cgc ctg gcc atg gag cgc cag     2188
 Ile Thr Lys Gly Val Lys Glu Asp Phe Arg Leu Ala Met Glu Arg Gln
             670                 675                 680

 gtc tcc cgc tgt gga gag aat ctg atg gtg gtt ctg cac agg ttc tgc     2236
 Val Ser Arg Cys Gly Glu Asn Leu Met Val Val Leu His Arg Phe Cys
         685                 690                 695

 att aat gag aag atc ttg ctc ctt cag act ctg acc tgag tggagacctt     2286
 Ile Asn Glu Lys Ile Leu Leu Leu Gln Thr Leu Thr 
     700                 705                 710

 tccaccagac acagctcggg cctgtgtaat tgtaggagaa gacactcagc agtgattgcc   2346

 atggcacaga gccgtggtca ttgttgctgt tacaaagaag aaaaccatct gagttctaac   2406

 tccttggttg cttaaaagta gttcccaaga gtctgagaag ctatttctat ttttaagagt   2466

 cattttttgt aatttttgta aaacaaaagt accaatctgt tttgtaaata aaaatcatcc   2526

 taaaatttga aaaaaaaaaa a                                             2547




      <210> 170
      <211> 2625
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (143)..(2350)

      <400> 170
 aaggatcctt aattaaatta atcccccccc cccccccgcc cccgcggtgg cggcggcggc     60

 ggcggtggct gccgtggcgg ctgagagtcc agagccggac gttccggccg cttcgggctg    120

 gcggctggag agcgctcggg tc atg tct gcc cag ggg gac tgc gag ttc ctg     172
                          Met Ser Ala Gln Gly Asp Cys Glu Phe Leu
                            1               5                  10

 gtg cag cga gcc cgg gag ttg gtg ccg caa gac ctg tgg gca gcc aag      220
 Val Gln Arg Ala Arg Glu Leu Val Pro Gln Asp Leu Trp Ala Ala Lys
                  15                  20                  25

 gcg tgg ctg atc acg gcc cgc agc ctc tac ccg gca gac ttt aac atc      268
 Ala Trp Leu Ile Thr Ala Arg Ser Leu Tyr Pro Ala Asp Phe Asn Ile
              30                  35                  40

 cag tat gag atg tac acc atc gag cgg aat gca gag cgg acc gcc acc      316
 Gln Tyr Glu Met Tyr Thr Ile Glu Arg Asn Ala Glu Arg Thr Ala Thr
          45                  50                  55

 gcc ggg agg ctg ctg tac gac atg ttt gtg aat ttc cca gac cag ccg      364
 Ala Gly Arg Leu Leu Tyr Asp Met Phe Val Asn Phe Pro Asp Gln Pro
      60                  65                  70

 gtg gtg tgg aga gaa atc agc att att aca tca gca tta agg aac gat      412
 Val Val Trp Arg Glu Ile Ser Ile Ile Thr Ser Ala Leu Arg Asn Asp
  75                  80                  85                  90

 tca cag gac aaa caa acc caa ttt tta aga agt tta ttt gaa act ctt      460
 Ser Gln Asp Lys Gln Thr Gln Phe Leu Arg Ser Leu Phe Glu Thr Leu
                  95                 100                 105

 cct ggt cgg gtc cag tgt gaa atg tta cta aag gtc acg gaa caa tgc      508
 Pro Gly Arg Val Gln Cys Glu Met Leu Leu Lys Val Thr Glu Gln Cys
             110                 115                 120

 ttc aac acg tta gaa cga tca gaa atg ttg ctt cta ctt ttg agg cgc      556
 Phe Asn Thr Leu Glu Arg Ser Glu Met Leu Leu Leu Leu Leu Arg Arg
         125                 130                 135

 ttc cct gaa acg gtg gtg cag cat ggg gtt ggc ctt ggg gag gca cta      604
 Phe Pro Glu Thr Val Val Gln His Gly Val Gly Leu Gly Glu Ala Leu
     140                 145                 150

 tta gag gct gaa act att gaa gaa caa gaa tct cca gtg aac tgc ttt      652
 Leu Glu Ala Glu Thr Ile Glu Glu Gln Glu Ser Pro Val Asn Cys Phe
 155                 160                 165                 170

 aga aaa tta ttt gtt tgt gat gtc ctt cct cta ata att aac aac cat      700
 Arg Lys Leu Phe Val Cys Asp Val Leu Pro Leu Ile Ile Asn Asn His
                 175                 180                 185

 gat gtt cga tta cct gcc aat tta ttg tat aag tac ttg aac aaa gca      748
 Asp Val Arg Leu Pro Ala Asn Leu Leu Tyr Lys Tyr Leu Asn Lys Ala
             190                 195                 200

 gct gaa ttt tat atc aat tat gtc act agg tct act caa ata gaa aat      796
 Ala Glu Phe Tyr Ile Asn Tyr Val Thr Arg Ser Thr Gln Ile Glu Asn
         205                 210                 215

 cag cat caa ggc gcc cag gat aca tct gat tta atg tca cct agc aaa      844
 Gln His Gln Gly Ala Gln Asp Thr Ser Asp Leu Met Ser Pro Ser Lys
     220                 225                 230

 cgt agc tct cag aag tac ata ata gaa ggg ctg acg gaa aaa tca tcc      892
 Arg Ser Ser Gln Lys Tyr Ile Ile Glu Gly Leu Thr Glu Lys Ser Ser
 235                 240                 245                 250

 cag atc gtg gac cct tgg gag agg ttg ttt aag att ttg aat gtt gtt      940
 Gln Ile Val Asp Pro Trp Glu Arg Leu Phe Lys Ile Leu Asn Val Val
                 255                 260                 265

 gga atg aga tgt gaa tgg cag atg gat aaa gga aga cga agc tat gga      988
 Gly Met Arg Cys Glu Trp Gln Met Asp Lys Gly Arg Arg Ser Tyr Gly
             270                 275                 280

 gat att ttg cat aga atg aag gat ctc tgc aga tac atg aac aac ttt     1036
 Asp Ile Leu His Arg Met Lys Asp Leu Cys Arg Tyr Met Asn Asn Phe
         285                 290                 295

 gat agt gaa gca cat gca aaa tat aaa aac caa gtg gtg tat tcc acc     1084
 Asp Ser Glu Ala His Ala Lys Tyr Lys Asn Gln Val Val Tyr Ser Thr
     300                 305                 310

 atg ctg gtc ttc ttt aag aat gca ttc cag tat gtc aac agc ata cag     1132
 Met Leu Val Phe Phe Lys Asn Ala Phe Gln Tyr Val Asn Ser Ile Gln
 315                 320                 325                 330

 cca tct ctc ttc caa ggt cct aat gcc ccg agc caa gtt cca ctg gtt     1180
 Pro Ser Leu Phe Gln Gly Pro Asn Ala Pro Ser Gln Val Pro Leu Val
                 335                 340                 345

 ctt ctt gaa gat gta tcg aat gtg tat ggt gat gta gaa att gat cgt     1228
 Leu Leu Glu Asp Val Ser Asn Val Tyr Gly Asp Val Glu Ile Asp Arg
             350                 355                 360

 aat aaa cac atc cat aaa aag agg aaa cta gct gaa gga aga gaa aaa     1276
 Asn Lys His Ile His Lys Lys Arg Lys Leu Ala Glu Gly Arg Glu Lys
         365                 370                 375

 acc atg agt tca gac gat gaa gac tgt tcg gcg aaa gga aga aat cgt     1324
 Thr Met Ser Ser Asp Asp Glu Asp Cys Ser Ala Lys Gly Arg Asn Arg
     380                 385                 390

 cac att gta gtc aat aaa gcc gaa ctt gct aac tcc act gaa gtg tta     1372
 His Ile Val Val Asn Lys Ala Glu Leu Ala Asn Ser Thr Glu Val Leu
 395                 400                 405                 410

 gaa agc ttt aaa ttg gcc agg gag agc tgg gag ttg ctc tat tcc cta     1420
 Glu Ser Phe Lys Leu Ala Arg Glu Ser Trp Glu Leu Leu Tyr Ser Leu
                 415                 420                 425

 gaa ttc ctt gac aaa gaa ttt aca agg att tgc ttg gcc tgg aag acg     1468
 Glu Phe Leu Asp Lys Glu Phe Thr Arg Ile Cys Leu Ala Trp Lys Thr
             430                 435                 440

 gat act tgg ctt tgg tta aga atc ttc ctc act gat atg atc atc tat     1516
 Asp Thr Trp Leu Trp Leu Arg Ile Phe Leu Thr Asp Met Ile Ile Tyr
         445                 450                 455

 cag ggt caa tat aaa aag gcg ata gcc agc ctg cat cac tta gca gct     1564
 Gln Gly Gln Tyr Lys Lys Ala Ile Ala Ser Leu His His Leu Ala Ala
     460                 465                 470

 ctc cag gga tcc att tct cag cca cag atc aca ggg cag ggg acc ctg     1612
 Leu Gln Gly Ser Ile Ser Gln Pro Gln Ile Thr Gly Gln Gly Thr Leu
 475                 480                 485                 490

 gag cat cag agg gcg ctc atc cag ctg gcg acg tgc cac ttt gcg cta     1660
 Glu His Gln Arg Ala Leu Ile Gln Leu Ala Thr Cys His Phe Ala Leu
                 495                 500                 505

 ggg gag tac aga atg aca tgt gaa aaa gtc ctt gat ttg atg tgc tac     1708
 Gly Glu Tyr Arg Met Thr Cys Glu Lys Val Leu Asp Leu Met Cys Tyr
             510                 515                 520

 atg gta ctc ccc att caa gat gga ggc aaa tcc cag gag gaa ccc tcg     1756
 Met Val Leu Pro Ile Gln Asp Gly Gly Lys Ser Gln Glu Glu Pro Ser
         525                 530                 535

 aaa gta aag ccc aaa ttt aga aaa ggt tcg gat ctg aag ctc ctg cct     1804
 Lys Val Lys Pro Lys Phe Arg Lys Gly Ser Asp Leu Lys Leu Leu Pro
     540                 545                 550

 tgt acc agc aag gct atc atg cca tac tgc ctc cat tta atg tta gcc     1852
 Cys Thr Ser Lys Ala Ile Met Pro Tyr Cys Leu His Leu Met Leu Ala
 555                 560                 565                 570

 tgt ttt aag ctt aga gct ttc aca gac aac aga gac gac atg gca ttg     1900
 Cys Phe Lys Leu Arg Ala Phe Thr Asp Asn Arg Asp Asp Met Ala Leu
                 575                 580                 585

 ggg cat gtg att gtg ttg ctt cag caa gag tgg cca cgg ggc gag aat     1948
 Gly His Val Ile Val Leu Leu Gln Gln Glu Trp Pro Arg Gly Glu Asn
             590                 595                 600

 ctt ttc ctg aaa gct gtc aat aaa att tgc caa caa gga aat ttc caa     1996
 Leu Phe Leu Lys Ala Val Asn Lys Ile Cys Gln Gln Gly Asn Phe Gln
         605                 610                 615

 tat gag aat ttt ttc aat tac gtt aca aat att gat atg ctg gag gaa     2044
 Tyr Glu Asn Phe Phe Asn Tyr Val Thr Asn Ile Asp Met Leu Glu Glu
     620                 625                 630

 ttt gcc tac ttg aga act cag gaa ggt ggg aaa att cat ctg gaa tta     2092
 Phe Ala Tyr Leu Arg Thr Gln Glu Gly Gly Lys Ile His Leu Glu Leu
 635                 640                 645                 650

 cta ccc aat caa gga atg ctg atc aag cct tct agc cct ccc atg ggg     2140
 Leu Pro Asn Gln Gly Met Leu Ile Lys Pro Ser Ser Pro Pro Met Gly
                 655                 660                 665

 tta ctg cag cag gaa ttc tta cct gtg ctt cag ccc agc ata cag act     2188
 Leu Leu Gln Gln Glu Phe Leu Pro Val Leu Gln Pro Ser Ile Gln Thr
             670                 675                 680

 gct gac agg cac cac act gta act cga ggc atc acc aaa ggc gtg aag     2236
 Ala Asp Arg His His Thr Val Thr Arg Gly Ile Thr Lys Gly Val Lys
         685                 690                 695

 gag gac ttt cgc ctg gcc atg gag cgc cag gtc tcc cgc tgt gga gag     2284
 Glu Asp Phe Arg Leu Ala Met Glu Arg Gln Val Ser Arg Cys Gly Glu
     700                 705                 710

 aat ctg atg gtg gtt ctg cac agg ttc tgc att aat gag aag atc ttg     2332
 Asn Leu Met Val Val Leu His Arg Phe Cys Ile Asn Glu Lys Ile Leu
 715                 720                 725                 730

 ctc ctt cag act ctg acc tgagtg gagacctttc caccagacac agctcgggcc     2386
 Leu Leu Gln Thr Leu Thr 
                 735

 tgtgtaattg taggagaaga cactcagcag tgattgccat ggcacagagc cgtggtcatt   2446

 gttgctgtta caaagaagaa aaccatctga gttctaactc cttggttgct taaaagtagt   2506

 tcccaagagt ctgagaagct atttctattt ttaagagtca ttttttgtaa tttttgtaaa   2566

 acaaaagtac caatctgttt tgtaaataaa aatcatccta aaatttgaaa aaaaaaaaa    2625




      <210> 171
      <211> 6288
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (115)..(5250)

      <400> 171
 aagggagccc cgctcagcgc ggggagcgcc cggccccctc cccgccccat gcgcccgcgg     60

 ctctgaagcc tgagcggggc cgggggctgg gcggggccgg ggcccgccgt aggc  atg     117
                                                              Met
                                                                1

 gcg tcc ggg agc cgg tgg cgg ccg aca ccg ccg ccg ctg ctg ttg ctg      165
 Ala Ser Gly Ser Arg Trp Arg Pro Thr Pro Pro Pro Leu Leu Leu Leu
               5                  10                  15

 ctg ctg ctg gcg ctg gcg gcg cgc gcg gac ggc ctg gag ttc ggc ggc      213
 Leu Leu Leu Ala Leu Ala Ala Arg Ala Asp Gly Leu Glu Phe Gly Gly
          20                  25                  30

 ggc ccc ggg cag tgg gct cgc tac gcg cgc tgg gcg ggc gcg gcg agc      261
 Gly Pro Gly Gln Trp Ala Arg Tyr Ala Arg Trp Ala Gly Ala Ala Ser
      35                  40                  45

 agc ggc gag ctc agc ttc agc ctg cgc acc aac gcc acg cgc gcg ctg      309
 Ser Gly Glu Leu Ser Phe Ser Leu Arg Thr Asn Ala Thr Arg Ala Leu
  50                  55                  60                  65

 ctg ctc tac ctg gac gac ggc ggc gac tgc gac ttc ctg gag ctg ctg      357
 Leu Leu Tyr Leu Asp Asp Gly Gly Asp Cys Asp Phe Leu Glu Leu Leu
                  70                  75                  80

 ctg gtg gac ggc cgc ctg cgg ctg cgc ttc acg ctt tcg tgc gcc gag      405
 Leu Val Asp Gly Arg Leu Arg Leu Arg Phe Thr Leu Ser Cys Ala Glu
              85                  90                  95

 ccg gcc acg ctg cag ctg gac acg ccg gtg gcc gac gac cgc tgg cac      453
 Pro Ala Thr Leu Gln Leu Asp Thr Pro Val Ala Asp Asp Arg Trp His
         100                 105                 110

 atg gtg ctg ctg acc cgc gac gcg cgc cgc acg gcg ctg gcg gtg gac      501
 Met Val Leu Leu Thr Arg Asp Ala Arg Arg Thr Ala Leu Ala Val Asp
     115                 120                 125

 ggc gag gcc cgc gcc gcc gag gtg cgc tcc aag cgg cgc gag atg cag      549
 Gly Glu Ala Arg Ala Ala Glu Val Arg Ser Lys Arg Arg Glu Met Gln
 130                 135                 140                 145

 gtg gcc agc gac ctg ttc gtg ggc ggc atc ccg ccc gac gtg cgc ctc      597
 Val Ala Ser Asp Leu Phe Val Gly Gly Ile Pro Pro Asp Val Arg Leu
                 150                 155                 160

 tcg gcg ctt acg ctg agc acc gtc aag tac gag ccg ccc ttc cgc ggt      645
 Ser Ala Leu Thr Leu Ser Thr Val Lys Tyr Glu Pro Pro Phe Arg Gly
             165                 170                 175

 ctc ttg gcc aac ctg aag ctg ggc gag cgg ccc ccc gcg ctg ctg ggc      693
 Leu Leu Ala Asn Leu Lys Leu Gly Glu Arg Pro Pro Ala Leu Leu Gly
         180                 185                 190

 agc cag ggc ctg cgc ggc gcc acc gcc gac ccg ctg tgc gcg ccc gcg      741
 Ser Gln Gly Leu Arg Gly Ala Thr Ala Asp Pro Leu Cys Ala Pro Ala
     195                 200                 205

 cgc aac ccc tgc gcc aac ggc ggc ctc tgc acc gtg ctg gcc ccc ggc      789
 Arg Asn Pro Cys Ala Asn Gly Gly Leu Cys Thr Val Leu Ala Pro Gly
 210                 215                 220                 225

 gag gtg ggc tgc gac tgc agc cac acg ggc ttc ggc ggc aag ttc tgc      837
 Glu Val Gly Cys Asp Cys Ser His Thr Gly Phe Gly Gly Lys Phe Cys
                 230                 235                 240

 agc gaa gag gag cac ccc atg gaa ggt ccg gct cac ctg acg tta aac      885
 Ser Glu Glu Glu His Pro Met Glu Gly Pro Ala His Leu Thr Leu Asn
             245                 250                 255

 agc gaa gta ggg tcc tta ctg ttc tcc gag ggg ggg gcc ggg aga gga      933
 Ser Glu Val Gly Ser Leu Leu Phe Ser Glu Gly Gly Ala Gly Arg Gly
         260                 265                 270

 gga gcc ggc gat gtg cac cag cca aca aaa ggc aag gag gag ttt gtg      981
 Gly Ala Gly Asp Val His Gln Pro Thr Lys Gly Lys Glu Glu Phe Val
     275                 280                 285

 gcg acc ttc aaa ggc aat gag ttc ttc tgc tac gac ctg tca cac aac     1029
 Ala Thr Phe Lys Gly Asn Glu Phe Phe Cys Tyr Asp Leu Ser His Asn
 290                 295                 300                 305

 ccc atc cag agc agc act gat gag atc aca ctg gcc ttc cgc acc ctg     1077
 Pro Ile Gln Ser Ser Thr Asp Glu Ile Thr Leu Ala Phe Arg Thr Leu
                 310                 315                 320

 caa cgc aac ggc ctg atg ctg cat aca ggc aag tcg gcc gac tac gtc     1125
 Gln Arg Asn Gly Leu Met Leu His Thr Gly Lys Ser Ala Asp Tyr Val
             325                 330                 335

 aac ctg tcc ctc aag tct ggg gct gtc tgg ctg gtc atc aac cta ggc     1173
 Asn Leu Ser Leu Lys Ser Gly Ala Val Trp Leu Val Ile Asn Leu Gly
         340                 345                 350

 tca ggt gcc ttc gag gcc ctt gtg gaa ccc gtc aat ggc aag ttc aac     1221
 Ser Gly Ala Phe Glu Ala Leu Val Glu Pro Val Asn Gly Lys Phe Asn
     355                 360                 365

 gac aac gcc tgg cac gac gtc cgg gtc acc cga aac ctg cgc cag cac     1269
 Asp Asn Ala Trp His Asp Val Arg Val Thr Arg Asn Leu Arg Gln His
 370                 375                 380                 385

 gca ggg att gga cac gct atg gta aac aaa ctg cat tat ctg gtg acc     1317
 Ala Gly Ile Gly His Ala Met Val Asn Lys Leu His Tyr Leu Val Thr
                 390                 395                 400

 atc tcg gtg gac ggg atc ctg acc acc aca ggc tac acg cag gag gat     1365
 Ile Ser Val Asp Gly Ile Leu Thr Thr Thr Gly Tyr Thr Gln Glu Asp
             405                 410                 415

 tac acc atg ctg ggc tct gat gac ttc ttc tac att ggg ggc agc ccc     1413
 Tyr Thr Met Leu Gly Ser Asp Asp Phe Phe Tyr Ile Gly Gly Ser Pro
         420                 425                 430

 aac aca gct gac ctg ccg ggc tcg ccc gtc agc aac aac ttc atg ggc     1461
 Asn Thr Ala Asp Leu Pro Gly Ser Pro Val Ser Asn Asn Phe Met Gly
     435                 440                 445

 tgc ctc aag gac gtg gtc tat aag aac aat gac ttc aaa ttg gaa cta     1509
 Cys Leu Lys Asp Val Val Tyr Lys Asn Asn Asp Phe Lys Leu Glu Leu
 450                 455                 460                 465

 tcc cgc ctg gca aag gaa ggg gac ccc aag atg aag ctg cag ggg gac     1557
 Ser Arg Leu Ala Lys Glu Gly Asp Pro Lys Met Lys Leu Gln Gly Asp
                 470                 475                 480

 ttg tca ttc cgc tgt gag gat gtg gct gcc ctg gac cct gtg acc ttt     1605
 Leu Ser Phe Arg Cys Glu Asp Val Ala Ala Leu Asp Pro Val Thr Phe
             485                 490                 495

 gag agt ccc gag gcc ttt gtg gcg ctg ccc cgc tgg agc gct aag cgc     1653
 Glu Ser Pro Glu Ala Phe Val Ala Leu Pro Arg Trp Ser Ala Lys Arg
         500                 505                 510

 act ggc tcc atc tcc cta gac ttc cgc acc acc gag ccc aat ggg ctg     1701
 Thr Gly Ser Ile Ser Leu Asp Phe Arg Thr Thr Glu Pro Asn Gly Leu
     515                 520                 525

 ctg ctc ttc agc cag ggc cgg cgg gct ggg ggt gga gct ggc agc cac     1749
 Leu Leu Phe Ser Gln Gly Arg Arg Ala Gly Gly Gly Ala Gly Ser His
 530                 535                 540                 545

 agc tct gct cag cgg gcc gac tac ttt gcc atg gag cta ttg gac ggc     1797
 Ser Ser Ala Gln Arg Ala Asp Tyr Phe Ala Met Glu Leu Leu Asp Gly
                 550                 555                 560

 cac ctc tat ctt ctg ctg gac atg gga tct ggg ggc atc aag ctg cgg     1845
 His Leu Tyr Leu Leu Leu Asp Met Gly Ser Gly Gly Ile Lys Leu Arg
             565                 570                 575

 gca tcc agc cgc aag gtc aat gat ggc gag tgg tgt cac gtg gac ttc     1893
 Ala Ser Ser Arg Lys Val Asn Asp Gly Glu Trp Cys His Val Asp Phe
         580                 585                 590

 cag agg gat ggg cga aaa ggc tcc atc tca gtg aat agt cgc agc acg     1941
 Gln Arg Asp Gly Arg Lys Gly Ser Ile Ser Val Asn Ser Arg Ser Thr
     595                 600                 605

 ccg ttc ttg gcc act gga gac agc gag att ctg gac ctg gag agt gag     1989
 Pro Phe Leu Ala Thr Gly Asp Ser Glu Ile Leu Asp Leu Glu Ser Glu
 610                 615                 620                 625

 ctg tac ctg ggc ggt ctc cct gag ggg ggc cgg gtg gac ctg ccc ctg     2037
 Leu Tyr Leu Gly Gly Leu Pro Glu Gly Gly Arg Val Asp Leu Pro Leu
                 630                 635                 640

 ccc cca gag gtg tgg aca gca gca ctc cgg gca ggc tac gtg ggc tgt     2085
 Pro Pro Glu Val Trp Thr Ala Ala Leu Arg Ala Gly Tyr Val Gly Cys
             645                 650                 655

 gtg cgg gac ctc ttc ata gat ggg cgt agc cga gac ctc cgg ggc ctg     2133
 Val Arg Asp Leu Phe Ile Asp Gly Arg Ser Arg Asp Leu Arg Gly Leu
         660                 665                 670

 gct gag gct cag ggg gct gtg ggc gtt gcc ccc ttt tgc tcc cgg gag     2181
 Ala Glu Ala Gln Gly Ala Val Gly Val Ala Pro Phe Cys Ser Arg Glu
     675                 680                 685

 acg ctg aag cag tgt gca tct gcc ccc tgt cgc aat ggg ggc gtc tgt     2229
 Thr Leu Lys Gln Cys Ala Ser Ala Pro Cys Arg Asn Gly Gly Val Cys
 690                 695                 700                 705

 cga gaa ggc tgg aac cgc ttc atc tgt gac tgc atc ggg acc ggc ttt     2277
 Arg Glu Gly Trp Asn Arg Phe Ile Cys Asp Cys Ile Gly Thr Gly Phe
                 710                 715                 720

 ctt ggg cgg gtc tgt gag aga gag gcc acg gtc ctg agc tac gat ggc     2325
 Leu Gly Arg Val Cys Glu Arg Glu Ala Thr Val Leu Ser Tyr Asp Gly
             725                 730                 735

 tcc atg tac atg aag atc atg ctg cct aac gcc atg cac acg gag gca     2373
 Ser Met Tyr Met Lys Ile Met Leu Pro Asn Ala Met His Thr Glu Ala
         740                 745                 750

 gag gat gtg tcc ctg cgt ttc atg tcc cag cgg gcc tac gga ctc atg     2421
 Glu Asp Val Ser Leu Arg Phe Met Ser Gln Arg Ala Tyr Gly Leu Met
     755                 760                 765

 atg gcc acc act tcc agg gag tct gcc gac acc cta cgc ctg gag ctg     2469
 Met Ala Thr Thr Ser Arg Glu Ser Ala Asp Thr Leu Arg Leu Glu Leu
 770                 775                 780                 785

 gat ggg ggg cag atg aag ctc act gtc aac ctc gac tgc ctg cgc gtc     2517
 Asp Gly Gly Gln Met Lys Leu Thr Val Asn Leu Asp Cys Leu Arg Val
                 790                 795                 800

 ggc tgc gca ccc agt aaa ggc ccc gaa acg ctg ttt gcg ggg cac aag     2565
 Gly Cys Ala Pro Ser Lys Gly Pro Glu Thr Leu Phe Ala Gly His Lys
             805                 810                 815

 ctc aat gac aat gag tgg cac acg gtg agg gtg gtc cgg cgt ggc aag     2613
 Leu Asn Asp Asn Glu Trp His Thr Val Arg Val Val Arg Arg Gly Lys
         820                 825                 830

 agc ctg cag ctg tct gtg gac aac gtg act gtg gag gga cag atg gca     2661
 Ser Leu Gln Leu Ser Val Asp Asn Val Thr Val Glu Gly Gln Met Ala
     835                 840                 845

 gga gcc cat atg cgg ctg gag ttc cac aac att gag acg ggc atc atg     2709
 Gly Ala His Met Arg Leu Glu Phe His Asn Ile Glu Thr Gly Ile Met
 850                 855                 860                 865

 acg gag cgg cgg ttt atc tcc gtg gtg ccc tcc aac ttc atc ggg cat     2757
 Thr Glu Arg Arg Phe Ile Ser Val Val Pro Ser Asn Phe Ile Gly His
                 870                 875                 880

 ctg agt ggg ctc gtg ttc aat ggc cag ccc tac atg gac cag tgc aag     2805
 Leu Ser Gly Leu Val Phe Asn Gly Gln Pro Tyr Met Asp Gln Cys Lys
             885                 890                 895

 gat ggt gac atc acc tac tgt gag ctc aat gct cgc ttt ggc ctg cgt     2853
 Asp Gly Asp Ile Thr Tyr Cys Glu Leu Asn Ala Arg Phe Gly Leu Arg
         900                 905                 910

 gcc att gtg gcc gat ccc gtc acc ttc aag agt cgc agc agc tac ctg     2901
 Ala Ile Val Ala Asp Pro Val Thr Phe Lys Ser Arg Ser Ser Tyr Leu
     915                 920                 925

 gca ctc gcc acg ctc caa gcc tat gct tcc atg cac ctc ttc ttc cag     2949
 Ala Leu Ala Thr Leu Gln Ala Tyr Ala Ser Met His Leu Phe Phe Gln
 930                 935                 940                 945

 ttc aag acc acg gcc cct gat ggg ctt ctt ctg ttc aac tcg ggc aac     2997
 Phe Lys Thr Thr Ala Pro Asp Gly Leu Leu Leu Phe Asn Ser Gly Asn
                 950                 955                 960

 ggc aat gac ttc att gtc atc gag ctg gtc aag ggg tac atc cac tac     3045
 Gly Asn Asp Phe Ile Val Ile Glu Leu Val Lys Gly Tyr Ile His Tyr
             965                 970                 975

 gtg ttt gac ctg ggg aat ggc ccg tcc ttg atg aag ggg aac tca gac     3093
 Val Phe Asp Leu Gly Asn Gly Pro Ser Leu Met Lys Gly Asn Ser Asp
         980                 985                 990

 aaa cca gtc aat gac aac cag tgg cac aac gtg gtg gtg tcc agg gac     3141
 Lys Pro Val Asn Asp Asn Gln Trp His Asn Val Val Val Ser Arg Asp
     995                1000                1005

 cca ggc aac gtg cac acg ctc aag att gac tcc cgc act gtc acg cag     3189
 Pro Gly Asn Val His Thr Leu Lys Ile Asp Ser Arg Thr Val Thr Gln
1010                1015                1020                1025

 cac tcc aat ggc gcc cga aac ctc gat ctc aaa ggg gag ttg tac att     3237
 His Ser Asn Gly Ala Arg Asn Leu Asp Leu Lys Gly Glu Leu Tyr Ile
                1030                1035                1040

 ggc ggt ctg agc aag aat atg ttc agc aac ctg ccc aag ctg gtg gcc     3285
 Gly Gly Leu Ser Lys Asn Met Phe Ser Asn Leu Pro Lys Leu Val Ala
            1045                1050                1055

 tcc cgg gat ggc ttt cag ggc tgc ctg gcc tca gtg gac ctc aac gga     3333
 Ser Arg Asp Gly Phe Gln Gly Cys Leu Ala Ser Val Asp Leu Asn Gly
        1060                1065                1070

 cgt ctc cca gac ctc atc gcc gac gcc ctg cac cgc att ggg cag gtg     3381
 Arg Leu Pro Asp Leu Ile Ala Asp Ala Leu His Arg Ile Gly Gln Val
    1075                1080                1085

 gag agg ggc tgt gat ggc ccc agc acc acc tgc act gaa gag tcc tgt     3429
 Glu Arg Gly Cys Asp Gly Pro Ser Thr Thr Cys Thr Glu Glu Ser Cys
1090                1095                1100                1105

 gcc aac cag ggc gtc tgc ttg cag cag tgg gat ggc ttc acc tgc gac     3477
 Ala Asn Gln Gly Val Cys Leu Gln Gln Trp Asp Gly Phe Thr Cys Asp
                1110                1115                1120

 tgc acc atg act tcc tat gga ggc cct gtc tgc aat gat ccc ggg acc     3525
 Cys Thr Met Thr Ser Tyr Gly Gly Pro Val Cys Asn Asp Pro Gly Thr
            1125                1130                1135

 aca tac atc ttt ggg aag ggg gga gcg ctc atc acc tac acg tgg ccc     3573
 Thr Tyr Ile Phe Gly Lys Gly Gly Ala Leu Ile Thr Tyr Thr Trp Pro
        1140                1145                1150

 ccc aat gac agg ccc agc acg agg atg gat cgc ctg gcc gtg ggc ttc     3621
 Pro Asn Asp Arg Pro Ser Thr Arg Met Asp Arg Leu Ala Val Gly Phe
    1155                1160                1165

 agc acc cac cag cgg agc gct gtg ctg gtg cgg gtg gac agc gcc tcc     3669
 Ser Thr His Gln Arg Ser Ala Val Leu Val Arg Val Asp Ser Ala Ser
1170                1175                1180                1185

 ggc ctt gga gac tac ctg cag ctg cac atc gac cag ggc acc gtg ggg     3717
 Gly Leu Gly Asp Tyr Leu Gln Leu His Ile Asp Gln Gly Thr Val Gly
                1190                1195                1200

 gtg atc ttt aac gtg ggc acg gac gac att acc atc gac gag ccc aac     3765
 Val Ile Phe Asn Val Gly Thr Asp Asp Ile Thr Ile Asp Glu Pro Asn
            1205                1210                1215

 gcc ata gta agc gac ggc aaa tac cac gtg gtg cgc ttc act cga agc     3813
 Ala Ile Val Ser Asp Gly Lys Tyr His Val Val Arg Phe Thr Arg Ser
        1220                1225                1230

 ggc ggc aac gcc acc ctg cag gtg gac agc tgg ccg gtc aac gag cgg     3861
 Gly Gly Asn Ala Thr Leu Gln Val Asp Ser Trp Pro Val Asn Glu Arg
    1235                1240                1245

 tac ccg gca gga aac ttt gat aac gag cgc ctg gcg att gct aga cag     3909
 Tyr Pro Ala Gly Asn Phe Asp Asn Glu Arg Leu Ala Ile Ala Arg Gln
1250                1255                1260                1265

 aga atc ccc tac cgg ctt ggt cga gta gta gat gag tgg ctg ctc gac     3957
 Arg Ile Pro Tyr Arg Leu Gly Arg Val Val Asp Glu Trp Leu Leu Asp
                1270                1275                1280

 aaa ggc cgc cag ctg acc atc ttc aac agc cag gct gcc atc aag atc     4005
 Lys Gly Arg Gln Leu Thr Ile Phe Asn Ser Gln Ala Ala Ile Lys Ile
            1285                1290                1295

 ggg ggc cgg gat cag ggc cgc ccc ttc cag ggc cag gtg tcc ggc ctc     4053
 Gly Gly Arg Asp Gln Gly Arg Pro Phe Gln Gly Gln Val Ser Gly Leu
        1300                1305                1310

 tac tac aat ggg ctc aag gtg ctg gcg ctg gcc gcc gag agc gac ccc     4101
 Tyr Tyr Asn Gly Leu Lys Val Leu Ala Leu Ala Ala Glu Ser Asp Pro
    1315                1320                1325

 aat gtg cgg act gag ggt cac ctg cgc ctg gtg ggg gag ggg ccg tcc     4149
 Asn Val Arg Thr Glu Gly His Leu Arg Leu Val Gly Glu Gly Pro Ser
1330                1335                1340                1345

 gtg ctg ctc agt gcg gag acc acg gcc acc acc ctg ctg gct gac atg     4197
 Val Leu Leu Ser Ala Glu Thr Thr Ala Thr Thr Leu Leu Ala Asp Met
                1350                1355                1360

 gcc acc acc atc atg gag act acc acc acc atg gcc act acc acc acg     4245
 Ala Thr Thr Ile Met Glu Thr Thr Thr Thr Met Ala Thr Thr Thr Thr
            1365                1370                1375

 cgc cgg ggc cgc tcc ccc aca ctg agg gac agc acc acc cag aac aca     4293
 Arg Arg Gly Arg Ser Pro Thr Leu Arg Asp Ser Thr Thr Gln Asn Thr
        1380                1385                1390

 gat gac ctg ctg gtg gcc tct gct gag tgt cca agc gat gat gag gac     4341
 Asp Asp Leu Leu Val Ala Ser Ala Glu Cys Pro Ser Asp Asp Glu Asp
    1395                1400                1405

 ctg gag gag tgt gag ccc agt act gga gga gag tta ata ttg ccc att     4389
 Leu Glu Glu Cys Glu Pro Ser Thr Gly Gly Glu Leu Ile Leu Pro Ile
1410                1415                1420                1425

 atc acg gag gac tcc tta gac ccc cct ccc gtg gcc acc cga tcc ccc     4437
 Ile Thr Glu Asp Ser Leu Asp Pro Pro Pro Val Ala Thr Arg Ser Pro
                1430                1435                1440

 ttc gtg ccc ccg ccc cct acc ttc tac ccc ttc ctc acg gga gtg ggc     4485
 Phe Val Pro Pro Pro Pro Thr Phe Tyr Pro Phe Leu Thr Gly Val Gly
            1445                1450                1455

 gcc acc caa gac acg ctg ccc ccg ccc gcc gcg cgc cgc ccg ccc tct     4533
 Ala Thr Gln Asp Thr Leu Pro Pro Pro Ala Ala Arg Arg Pro Pro Ser
        1460                1465                1470

 ggg ggc ccg tgc cag gcc gag cgg gac gac agc gac tgc gag gag ccc     4581
 Gly Gly Pro Cys Gln Ala Glu Arg Asp Asp Ser Asp Cys Glu Glu Pro
    1475                1480                1485

 atc gag gcc tcg ggc ttc gcc tcc ggg gag gtc ttt gac tcc agc ctc     4629
 Ile Glu Ala Ser Gly Phe Ala Ser Gly Glu Val Phe Asp Ser Ser Leu
1490                1495                1500                1505

 ccc ccc acg gac gac gag gac ttt tac acc acc ttt ccc ctg gtc acg     4677
 Pro Pro Thr Asp Asp Glu Asp Phe Tyr Thr Thr Phe Pro Leu Val Thr
                1510                1515                1520

 gac cgc acc acc ctc ctg tca ccc cgc aaa ccc gct ccc cgg ccc aac     4725
 Asp Arg Thr Thr Leu Leu Ser Pro Arg Lys Pro Ala Pro Arg Pro Asn
            1525                1530                1535

 ctc agg aca gat ggg gcc acg ggc gcc cct ggg gtg ctg ttt gcc ccc     4773
 Leu Arg Thr Asp Gly Ala Thr Gly Ala Pro Gly Val Leu Phe Ala Pro
        1540                1545                1550

 tcc gcc ccg gcc ccc aac ctg ccg gcg gga aaa atg aac cac cga gac     4821
 Ser Ala Pro Ala Pro Asn Leu Pro Ala Gly Lys Met Asn His Arg Asp
    1555                1560                1565

 ccg ctt cag ccc ttg ctg gag aac ccg ccc ttg ggg ccc ggg gcc ccc     4869
 Pro Leu Gln Pro Leu Leu Glu Asn Pro Pro Leu Gly Pro Gly Ala Pro
1570                1575                1580                1585

 acg tcc ttt gag ccg cgg agg ccc cct ccc ctg cgc ccc ggc gtg acc     4917
 Thr Ser Phe Glu Pro Arg Arg Pro Pro Pro Leu Arg Pro Gly Val Thr
                1590                1595                1600

 tca gcc ccc ggc ttc ccc cat ctg ccc aca gcc aac ccc aca ggg cct     4965
 Ser Ala Pro Gly Phe Pro His Leu Pro Thr Ala Asn Pro Thr Gly Pro
            1605                1610                1615

 ggg gag cgg ggc ccg ccg ggc gca gtg gag gtg atc cgg gag tcc agc     5013
 Gly Glu Arg Gly Pro Pro Gly Ala Val Glu Val Ile Arg Glu Ser Ser
        1620                1625                1630

 agc acc acg ggc atg gtg gtg ggc att gtg gcg gcg gcg gcg ctc tgc     5061
 Ser Thr Thr Gly Met Val Val Gly Ile Val Ala Ala Ala Ala Leu Cys
    1635                1640                1645

 atc ctc atc ctc ctc tac gcc atg tat aag tac cgc aat cgt gat gag     5109
 Ile Leu Ile Leu Leu Tyr Ala Met Tyr Lys Tyr Arg Asn Arg Asp Glu
1650                1655                1660                1665

 ggc tcc tac cag gtg gac cag agc cga aac tac atc agt aac tcg gcc     5157
 Gly Ser Tyr Gln Val Asp Gln Ser Arg Asn Tyr Ile Ser Asn Ser Ala
                1670                1675                1680

 cag agc aat ggg gcg gtg gtg aaa gag aag gcc ccg gct gcc ccc aag     5205
 Gln Ser Asn Gly Ala Val Val Lys Glu Lys Ala Pro Ala Ala Pro Lys
            1685                1690                1695

 acg ccc agc aag gcc aag aag aac aaa gac aag gag tat tat gtc tga     5253
 Thr Pro Ser Lys Ala Lys Lys Asn Lys Asp Lys Glu Tyr Tyr Val 
        1700                1705                1710

 gcccccggca ctgcgcccca ctgccagctg cccctcctgg gagggcccgg gaggagggtg   5313

 ccaccctctc cctgccaggg gcctggggac cctctccctg gctgcctcag gcttctctta   5373

 cgaagaggaa acgcaaaaaa agaaaaggaa aaaccccgtg ctcgccccct tcctcctgcc   5433

 gtccactgcg cggcctcgtc agtcccgggg ctgactgtcc ctctcagctc tgcgcctgcc   5493

 aggcagggca cgtgctcaca gccctgggtt gatttatttt tttaaggggg tagttttatt   5553

 ttggtggggt tgggtgggaa ggaaggctgg gggttttgta aagtgtccac tgctcgtcct   5613

 gttaattttc ctcaattttt cttcttcttc cttctgtccc tcctgccttc cttctcttcc   5673

 caagccctcc aatccccatc ccaggcttgc tgtgtctcac tgtccccacc ctccttccct   5733

 acttcttttt ttgtgtgtct ggtttctccc ttcctttcct ccctttgggt ttccagagtc   5793

 ggtgggagaa gggcgggagg gtgggcccga gtggcccagt gggtgggtgg ggtggggtgg   5853

 ggcaagtgcc ccaactcccc tcaccaggag aggcacctgc ttggtgccgc ccagggaagg   5913

 ggctcaggcc tgacggaagg cctgttctgt gtgtgccgcc gggcgacgtg cattgatggg   5973

 gaagctgctg gaggagcagg ggtggggggt gggagggagg ggaaaggcaa atgcagatat   6033

 atattacaga caaatactct agattccacg agcagcagcc tgtggcaccc gctgggcgcg   6093

 ggcagcaggg aagagggagc aaggcattgt ccacagactg ctggggtcac ttctttgccc   6153

 acgggctccc tgctccccca gttttttttc tctctttgtt aacaaatgtg tctgagtctt   6213

 ggaaaacacc ccaaccccgg aaatgtgtgg gaaaaagaaa acaaaaactt tccaaattcc   6273

 aaaaaaaaaa aaaaa                                                    6288




      <210> 172
      <211> 724
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (200)..(667)

      <400> 172
 tggctctgac tcttcaccca tcttcaccca ggctggcccc tttggtgaaa ctacaactcc     60

 caggggtctg tgcgcgagaa ggcaggcggg tttttctacc ggaagtccgc tctagctctg    120

 ggccctacaa ctgcaccctg agccggagct gcccagtcgc cgcgggaccg gggccgctgg    180

 ggtctggacg ggggtcgcc atg atc cgc ttt atc ctc atc cag aac cgg gca     232
                      Met Ile Arg Phe Ile Leu Ile Gln Asn Arg Ala
                        1               5                  10

 ggc aag acg cgc ctg gcc aag tgg tac atg cag ttt gat gat gat gag      280
 Gly Lys Thr Arg Leu Ala Lys Trp Tyr Met Gln Phe Asp Asp Asp Glu
              15                  20                  25

 aaa cag aag ctg atc gag gag gtg cat gcc gtg gtc acc gtc cga gac      328
 Lys Gln Lys Leu Ile Glu Glu Val His Ala Val Val Thr Val Arg Asp
          30                  35                  40

 gcc aaa cac acc aac ttt gtg gag gtc ctg gca agc tcc gtt gct gac      376
 Ala Lys His Thr Asn Phe Val Glu Val Leu Ala Ser Ser Val Ala Asp
      45                  50                  55

 agc ctc tct gtt ctg cag ttc cgg aac ttt aag atc att tac cgc cgc      424
 Ser Leu Ser Val Leu Gln Phe Arg Asn Phe Lys Ile Ile Tyr Arg Arg
  60                  65                  70                  75

 tat gct ggc ctc tac ttc tgc atc tgt gtg gat gtc aat gac aac aac      472
 Tyr Ala Gly Leu Tyr Phe Cys Ile Cys Val Asp Val Asn Asp Asn Asn
                  80                  85                  90

 ctg gct tac ctg gag gcc att cac aac ttc gtg gag gtc tta aac gaa      520
 Leu Ala Tyr Leu Glu Ala Ile His Asn Phe Val Glu Val Leu Asn Glu
              95                 100                 105

 tat ttc cac aat gtc tgt gaa ctg gac ctg gtg ttc aac ttc tac aag      568
 Tyr Phe His Asn Val Cys Glu Leu Asp Leu Val Phe Asn Phe Tyr Lys
         110                 115                 120

 gtt tac acg gtc gtg gac gag atg ttc ctg gct ggc gaa atc cga gag      616
 Val Tyr Thr Val Val Asp Glu Met Phe Leu Ala Gly Glu Ile Arg Glu
     125                 130                 135

 acc agc cag acg aag gtg ctg aaa cag ctg ctg atg cta cag tcc ctg      664
 Thr Ser Gln Thr Lys Val Leu Lys Gln Leu Leu Met Leu Gln Ser Leu
 140                 145                 150                 155

 gag tgag ggcaggcgag ccccaccccg gccccggccc ctcctggact cgcctgctcg      721
 Glu 


 ctt                                                                  724




      <210> 173
      <211> 977
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (46)..(825)

      <400> 173
 agtgagcgct ggtggcggag ttaaagtcaa agcaggagag taatt    atg aat agc      54
                                                      Met Asn Ser
                                                        1

 gca gcg gga ttc tca cac cta gac cgt cgc gag cgg gtt ctc aag tta      102
 Ala Ala Gly Phe Ser His Leu Asp Arg Arg Glu Arg Val Leu Lys Leu
       5                  10                  15

 ggg gag agt ttc gag aag cag ccg cgc tgc gcc ttc cac act gtg cgc      150
 Gly Glu Ser Phe Glu Lys Gln Pro Arg Cys Ala Phe His Thr Val Arg
  20                  25                  30                  35

 tat gac ttc aaa cct gct tct att gac act tct tct gaa gga tac ctt      198
 Tyr Asp Phe Lys Pro Ala Ser Ile Asp Thr Ser Ser Glu Gly Tyr Leu
                  40                  45                  50

 gag gtt ggt gaa ggt gaa cag gtg acc ata act ctg cca aat ata gaa      246
 Glu Val Gly Glu Gly Glu Gln Val Thr Ile Thr Leu Pro Asn Ile Glu
              55                  60                  65

 ggt tca act cca cca gta act gtt ttc aaa ggt tca aaa aaa cct tac      294
 Gly Ser Thr Pro Pro Val Thr Val Phe Lys Gly Ser Lys Lys Pro Tyr
          70                  75                  80

 tta aaa gaa tgc att ttg att att aac cat gat act gga gaa tgt cgg      342
 Leu Lys Glu Cys Ile Leu Ile Ile Asn His Asp Thr Gly Glu Cys Arg
      85                  90                  95

 cta gaa aaa ctc agc agc aac atc act gta aaa aaa aca aga gtt gaa      390
 Leu Glu Lys Leu Ser Ser Asn Ile Thr Val Lys Lys Thr Arg Val Glu
 100                 105                 110                 115

 gga agc agt aaa att cag tat cgt aaa gaa caa cag caa caa caa atg      438
 Gly Ser Ser Lys Ile Gln Tyr Arg Lys Glu Gln Gln Gln Gln Gln Met
                 120                 125                 130

 tgg aat tca gcc agg act ccc aat ctt gta aaa cat tct cca tct gaa      486
 Trp Asn Ser Ala Arg Thr Pro Asn Leu Val Lys His Ser Pro Ser Glu
             135                 140                 145

 gat aag atg tcc cca gca tct cca ata gat gat atc gaa aga gaa ctg      534
 Asp Lys Met Ser Pro Ala Ser Pro Ile Asp Asp Ile Glu Arg Glu Leu
         150                 155                 160

 aag gca gaa gct agt cta atg gac cag atg agt agt tgt gat agt tca      582
 Lys Ala Glu Ala Ser Leu Met Asp Gln Met Ser Ser Cys Asp Ser Ser
     165                 170                 175

 tca gat tcc aaa agt tca tca tct tca agt agt gag gat agt tct agt      630
 Ser Asp Ser Lys Ser Ser Ser Ser Ser Ser Ser Glu Asp Ser Ser Ser
 180                 185                 190                 195

 gac tca gaa gat gaa gat tgc aaa tcc tct act tct gat aca ggg aat      678
 Asp Ser Glu Asp Glu Asp Cys Lys Ser Ser Thr Ser Asp Thr Gly Asn
                 200                 205                 210

 tgt gtc tca gga cat cct acc atg aca cag tac agg att cct gat ata      726
 Cys Val Ser Gly His Pro Thr Met Thr Gln Tyr Arg Ile Pro Asp Ile
             215                 220                 225

 gat gcc agt cat aat aga ttt cga gac aac agt ggc ctt ctg atg aat      774
 Asp Ala Ser His Asn Arg Phe Arg Asp Asn Ser Gly Leu Leu Met Asn
         230                 235                 240

 act tta aga aat gat ttg cag ctg agt gaa tca gga agt gac agt gat      822
 Thr Leu Arg Asn Asp Leu Gln Leu Ser Glu Ser Gly Ser Asp Ser Asp
     245                 250                 255

 gac tgaa gaaatattta gctataaata aaaatttata cagcatgtat aatttatttt      879
 Asp 
 260

 gtattaacaa taaaaattcc taagactgag ggaaatatgt cttaactttt gatgataaaa    939

 gaaattaaat ttgattcaga aatttcaaaa aaaaaaaa                            977




      <210> 174
      <211> 1311
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (37)..(1254)

      <400> 174
 accccggcgg ccctgcccgc ccctccctcc agcatc  atg gcc agc cca aga acc      54
                                          Met Ala Ser Pro Arg Thr
                                            1               5

 agg aag gtt ctt aaa gaa gtc agg gtg cag gat gag aac aac gtt tgt      102
 Arg Lys Val Leu Lys Glu Val Arg Val Gln Asp Glu Asn Asn Val Cys
              10                  15                  20

 ttt gag tgt ggc gcg ttc aat cct cag tgg gtc agt gtg acc tac ggc      150
 Phe Glu Cys Gly Ala Phe Asn Pro Gln Trp Val Ser Val Thr Tyr Gly
          25                  30                  35

 atc tgg atc tgc ctg gag tgc tcg ggg aga cac cgc ggg ctt ggg gtt      198
 Ile Trp Ile Cys Leu Glu Cys Ser Gly Arg His Arg Gly Leu Gly Val
      40                  45                  50

 cac ctc agc ttt gtg cgc tct gtt act atg gac aag tgg aag gac att      246
 His Leu Ser Phe Val Arg Ser Val Thr Met Asp Lys Trp Lys Asp Ile
  55                  60                  65                  70

 gag ctt gag aag atg aaa gct ggt ggg aat gct aag ttc cga gag ttc      294
 Glu Leu Glu Lys Met Lys Ala Gly Gly Asn Ala Lys Phe Arg Glu Phe
                  75                  80                  85

 ctg gag tct cag gag gat tac gat cct tgc tgg tcc ttg cag gag aag      342
 Leu Glu Ser Gln Glu Asp Tyr Asp Pro Cys Trp Ser Leu Gln Glu Lys
              90                  95                 100

 tac aac agc aga gcc gcg gcc ctc ttt agg gat aag gtg gtc gct ctg      390
 Tyr Asn Ser Arg Ala Ala Ala Leu Phe Arg Asp Lys Val Val Ala Leu
         105                 110                 115

 gcc gaa ggc aga gag tgg tct ctg gag tca tca cct gcc cag aac tgg      438
 Ala Glu Gly Arg Glu Trp Ser Leu Glu Ser Ser Pro Ala Gln Asn Trp
     120                 125                 130

 acc cca cct cag ccc agg acg ctg ccg tcc atg gtg cac cga gtc tct      486
 Thr Pro Pro Gln Pro Arg Thr Leu Pro Ser Met Val His Arg Val Ser
 135                 140                 145                 150

 ggc cag ccg cag agt gtg acc gcc tcc tcg gac aag gct ttt gaa gac      534
 Gly Gln Pro Gln Ser Val Thr Ala Ser Ser Asp Lys Ala Phe Glu Asp
                 155                 160                 165

 tgg ctg aat gat gac ctc ggc tcc tat caa ggg gcc cag ggg aat cgc      582
 Trp Leu Asn Asp Asp Leu Gly Ser Tyr Gln Gly Ala Gln Gly Asn Arg
             170                 175                 180

 tac gtg ggg ttt ggg aac acg cca ccg cct cag aag aaa gaa gat gac      630
 Tyr Val Gly Phe Gly Asn Thr Pro Pro Pro Gln Lys Lys Glu Asp Asp
         185                 190                 195

 ttc ctc aac aac gcc atg tcc tcc ctg tac tcg ggc tgg agc agc ttc      678
 Phe Leu Asn Asn Ala Met Ser Ser Leu Tyr Ser Gly Trp Ser Ser Phe
     200                 205                 210

 acc act gga gcc agc cgg ttt gcc tcg gca gcc aag gag ggc gct aca      726
 Thr Thr Gly Ala Ser Arg Phe Ala Ser Ala Ala Lys Glu Gly Ala Thr
 215                 220                 225                 230

 aag ttt gga tcc caa gcg agt cag aag gcg tcc gag ctg ggc cac agc      774
 Lys Phe Gly Ser Gln Ala Ser Gln Lys Ala Ser Glu Leu Gly His Ser
                 235                 240                 245

 ctg aac gag aac gtc ctc aag cct gcg cag gag aag gtg aag gag gga      822
 Leu Asn Glu Asn Val Leu Lys Pro Ala Gln Glu Lys Val Lys Glu Gly
             250                 255                 260

 aag att ttt gat gat gtc tcc agt ggg gtc tct cag ttg gcg tcc aag      870
 Lys Ile Phe Asp Asp Val Ser Ser Gly Val Ser Gln Leu Ala Ser Lys
         265                 270                 275

 gtc cag gga gtc ggt agt aag gga tgg cgg gac gtc acc acc ttt ttt      918
 Val Gln Gly Val Gly Ser Lys Gly Trp Arg Asp Val Thr Thr Phe Phe
     280                 285                 290

 tcg ggg aaa gca gag ggc ccc ttg gac agc ccc tcg gag ggc cac agt      966
 Ser Gly Lys Ala Glu Gly Pro Leu Asp Ser Pro Ser Glu Gly His Ser
 295                 300                 305                 310

 tat cag aac agc ggt ctg gac cac ttc caa aac agc aac ata gac cag     1014
 Tyr Gln Asn Ser Gly Leu Asp His Phe Gln Asn Ser Asn Ile Asp Gln
                 315                 320                 325

 agc ttc tgg gag acc ttt gga agt gct gag ccc acc aag acc cgc aag     1062
 Ser Phe Trp Glu Thr Phe Gly Ser Ala Glu Pro Thr Lys Thr Arg Lys
             330                 335                 340

 tcc ccg agc agc gac agc tgg acg tgc gcg gac acc tcc acc gag agg     1110
 Ser Pro Ser Ser Asp Ser Trp Thr Cys Ala Asp Thr Ser Thr Glu Arg
         345                 350                 355

 agg agc tcg gac agc tgg gag gtg tgg ggc tcg gcc tcc acc aac agg     1158
 Arg Ser Ser Asp Ser Trp Glu Val Trp Gly Ser Ala Ser Thr Asn Arg
     360                 365                 370

 aac agc aac agc gac ggc ggg gag ggc ggg gag ggc acc aag aag gca     1206
 Asn Ser Asn Ser Asp Gly Gly Glu Gly Gly Glu Gly Thr Lys Lys Ala
 375                 380                 385                 390

 gtg ccg ccg gcc gtg ccc act gat gat ggc tgg gac aac cag aac tgg     1254
 Val Pro Pro Ala Val Pro Thr Asp Asp Gly Trp Asp Asn Gln Asn Trp 
                 395                 400                 405

 tagggcccac tgcgcccccg tccccagcgc ccccgggcga cttcgtgttt gcactct      1311




      <210> 175
      <211> 4736
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (768)..(3587)

      <400> 175
 gggtttagag gtaagtttgc ctactttgtc gtctagtggg taaaattttg cggagagcgt     60

 tggatctggg aagcgggata gggatggatg ggttcatttg agagccacgg cttaaagcgg    120

 ttgcgatcag gatgggacac aggtttgttt ggggacaaca aagatggcat ttgtgagtgt    180

 tttgaagcaa cccgtactga ttacatcttt ctcccttgtg ttccttttat cccaggtttg    240

 aattttctcg gagaaagaca ggccggccac gaggaaaaca gaaacaagcc gcagcaacat    300

 ctaagccctt gaaaggatcc tgagagaggg gggaaaggga aaacagcagc caccagccca    360

 accacttgtg tcttctgccc cttcccacct atcttgccca ccccaccagc ccacgctgct    420

 tgggacttga aatctgtggc cgaaggaccg tcactacata acttcaaaaa taatcaacca    480

 ccctcccttc ccaaaccacc caaattcact catccagcgt ttactttttt gaatccactc    540

 agaacttttt tctgcgaccc ccctccctaa atggagttgg gtggggggga aatgaatact    600

 gagttggcct ttatttttta aaagactttt tgatccaatg aggcccccta aataattgag    660

 ttttgggtcc tggttggttg ttttattttt tttcctccaa aattttaccc cctcccccct    720

 gagcccgagg tgctgacgtc gcaaaaaaat tggataaaac caccatc  atg ggt tcg     776
                                                      Met Gly Ser
                                                        1

 ggt ccc ata gac ccc aaa gaa ctt ctc aag ggc ctg gac agc ttc ctt      824
 Gly Pro Ile Asp Pro Lys Glu Leu Leu Lys Gly Leu Asp Ser Phe Leu
       5                  10                  15

 aac cga gat ggg gaa gtc aaa agt gtg gat ggg att tcc aag atc ttc      872
 Asn Arg Asp Gly Glu Val Lys Ser Val Asp Gly Ile Ser Lys Ile Phe
  20                  25                  30                  35

 agt ttg atg aag gaa gca cga aag atg gtg agt cga tgc act tac ttg      920
 Ser Leu Met Lys Glu Ala Arg Lys Met Val Ser Arg Cys Thr Tyr Leu
                  40                  45                  50

 aac att ctc ctg cag acc cgt tca cca gaa ata ttg gtc aaa ttt att      968
 Asn Ile Leu Leu Gln Thr Arg Ser Pro Glu Ile Leu Val Lys Phe Ile
              55                  60                  65

 gac gtt ggc ggc tac aaa ctt ctt aac aat tgg ctg acg tat tca aag     1016
 Asp Val Gly Gly Tyr Lys Leu Leu Asn Asn Trp Leu Thr Tyr Ser Lys
          70                  75                  80

 aca acc aac aac att ccc ctc ctc cag caa att cta ctg acc ctg cag     1064
 Thr Thr Asn Asn Ile Pro Leu Leu Gln Gln Ile Leu Leu Thr Leu Gln
      85                  90                  95

 cat cta ccg ctc act gta gac cat ctc aag cag aac aac aca gct aaa     1112
 His Leu Pro Leu Thr Val Asp His Leu Lys Gln Asn Asn Thr Ala Lys
 100                 105                 110                 115

 ctg gtg aag cag ctg agc aag tca agt gag gat gaa gag ctc cgg aaa     1160
 Leu Val Lys Gln Leu Ser Lys Ser Ser Glu Asp Glu Glu Leu Arg Lys
                 120                 125                 130

 ttg gcc tca gtc ctt gtc agc gac tgg atg gct gtc atc cgc tct cag     1208
 Leu Ala Ser Val Leu Val Ser Asp Trp Met Ala Val Ile Arg Ser Gln
             135                 140                 145

 agc agt acc cag cct gct gag aaa gat aag aag aaa cgt aaa gat gaa     1256
 Ser Ser Thr Gln Pro Ala Glu Lys Asp Lys Lys Lys Arg Lys Asp Glu
         150                 155                 160

 gga aaa agt cga acc acc ctt cct gag cga cct ttg aca gag gtg aag     1304
 Gly Lys Ser Arg Thr Thr Leu Pro Glu Arg Pro Leu Thr Glu Val Lys
     165                 170                 175

 gct gag acc cgg gct gag gag gcc cca gag aag aag agg gag aag ccc     1352
 Ala Glu Thr Arg Ala Glu Glu Ala Pro Glu Lys Lys Arg Glu Lys Pro
 180                 185                 190                 195

 aag tct ctt cgc acc aca gca ccc agt cat gcc aag ttc cgt tcc act     1400
 Lys Ser Leu Arg Thr Thr Ala Pro Ser His Ala Lys Phe Arg Ser Thr
                 200                 205                 210

 gga cta gag ctg gag aca cca tcc ttg gtg cct gtg aag aag aat gcc     1448
 Gly Leu Glu Leu Glu Thr Pro Ser Leu Val Pro Val Lys Lys Asn Ala
             215                 220                 225

 agc aca gtg gtg gtt tct gac aag tac aac ctt aaa ccc atc ccc ctc     1496
 Ser Thr Val Val Val Ser Asp Lys Tyr Asn Leu Lys Pro Ile Pro Leu
         230                 235                 240

 aaa cgt cag agc aac gta gct gct cca gga gat gcc act ccc cct gca     1544
 Lys Arg Gln Ser Asn Val Ala Ala Pro Gly Asp Ala Thr Pro Pro Ala
     245                 250                 255

 gag aag aaa tac aag cca ctc aac aca aca cct aat gcc acc aaa gag     1592
 Glu Lys Lys Tyr Lys Pro Leu Asn Thr Thr Pro Asn Ala Thr Lys Glu
 260                 265                 270                 275

 atc aaa gtg aag atc atc ccg cca cag cct atg gag ggc ctg ggc ttt     1640
 Ile Lys Val Lys Ile Ile Pro Pro Gln Pro Met Glu Gly Leu Gly Phe
                 280                 285                 290

 ctg gat gct ctt aat tca gcc cct gtt cca ggc atc aaa att aag aag     1688
 Leu Asp Ala Leu Asn Ser Ala Pro Val Pro Gly Ile Lys Ile Lys Lys
             295                 300                 305

 aaa aaa aaa gta ctg tca cct acg gct gcc aag cca agc ccc ttt gaa     1736
 Lys Lys Lys Val Leu Ser Pro Thr Ala Ala Lys Pro Ser Pro Phe Glu
         310                 315                 320

 ggg aaa acg agc aca gaa cca agc aca gcc aaa cct tct tcc cca gaa     1784
 Gly Lys Thr Ser Thr Glu Pro Ser Thr Ala Lys Pro Ser Ser Pro Glu
     325                 330                 335

 cca gca cca cct tct gag gca atg gac gca gac cgt cca ggc acc ccg     1832
 Pro Ala Pro Pro Ser Glu Ala Met Asp Ala Asp Arg Pro Gly Thr Pro
 340                 345                 350                 355

 gtt ccc cct gtt gaa gtc ccg gag ctc atg gat aca gcc tct ttg gag     1880
 Val Pro Pro Val Glu Val Pro Glu Leu Met Asp Thr Ala Ser Leu Glu
                 360                 365                 370

 cca gga gct ctg gat gcc aag cca gtg gag agt cct gga gat cct aac     1928
 Pro Gly Ala Leu Asp Ala Lys Pro Val Glu Ser Pro Gly Asp Pro Asn
             375                 380                 385

 caa ctg acc cgg aaa ggc agg aag agg aaa agt gtg aca tgg cct gag     1976
 Gln Leu Thr Arg Lys Gly Arg Lys Arg Lys Ser Val Thr Trp Pro Glu
         390                 395                 400

 gaa ggc aaa ctg aga gaa tat ttc tat ttt gaa ttg gat gaa act gaa     2024
 Glu Gly Lys Leu Arg Glu Tyr Phe Tyr Phe Glu Leu Asp Glu Thr Glu
     405                 410                 415

 cga gta aat gtg aat aag atc aag gac ttt ggt gag gcg gct aag cga     2072
 Arg Val Asn Val Asn Lys Ile Lys Asp Phe Gly Glu Ala Ala Lys Arg
 420                 425                 430                 435

 gag ata ctg tca gac cga cat gca ttt gag aca gcg cgg cgt ctg agc     2120
 Glu Ile Leu Ser Asp Arg His Ala Phe Glu Thr Ala Arg Arg Leu Ser
                 440                 445                 450

 cat gat aac atg gag gag aag gtg ccc tgg gtg tgc ccc cgg ccc ctg     2168
 His Asp Asn Met Glu Glu Lys Val Pro Trp Val Cys Pro Arg Pro Leu
             455                 460                 465

 gtt ctg ccc tca cct ctt gtc acc cct gga agc aat agt cag gag cga     2216
 Val Leu Pro Ser Pro Leu Val Thr Pro Gly Ser Asn Ser Gln Glu Arg
         470                 475                 480

 tat atc cag gct gag cgg gag aag gga atc ctt cag gag ctc ttc ctg     2264
 Tyr Ile Gln Ala Glu Arg Glu Lys Gly Ile Leu Gln Glu Leu Phe Leu
     485                 490                 495

 aac aag gag agt cct cat gag cct gat cct gag ccc tac gag ccc ata     2312
 Asn Lys Glu Ser Pro His Glu Pro Asp Pro Glu Pro Tyr Glu Pro Ile
 500                 505                 510                 515

 ccc cct aaa ctc atc ccc cta gat gag gag tgt tcc atg gat gag act     2360
 Pro Pro Lys Leu Ile Pro Leu Asp Glu Glu Cys Ser Met Asp Glu Thr
                 520                 525                 530

 ccg tat gtt gag act ctg gaa cct ggg ggg tca ggt ggc tca cct gat     2408
 Pro Tyr Val Glu Thr Leu Glu Pro Gly Gly Ser Gly Gly Ser Pro Asp
             535                 540                 545

 ggg gca gga ggc tcc aag ttg cct cca gtt ctg gcc aat ctt atg gga     2456
 Gly Ala Gly Gly Ser Lys Leu Pro Pro Val Leu Ala Asn Leu Met Gly
         550                 555                 560

 agc atg ggt gct gga aag ggc ccc caa ggc cct gga gga gga ggc att     2504
 Ser Met Gly Ala Gly Lys Gly Pro Gln Gly Pro Gly Gly Gly Gly Ile
     565                 570                 575

 aat gtc caa gag atc ctc acc tcc atc atg ggt agc cca aac agt cat     2552
 Asn Val Gln Glu Ile Leu Thr Ser Ile Met Gly Ser Pro Asn Ser His
 580                 585                 590                 595

 cct tca gag gaa cta ctg aaa caa cca gac tat tcg gac aag atc aag     2600
 Pro Ser Glu Glu Leu Leu Lys Gln Pro Asp Tyr Ser Asp Lys Ile Lys
                 600                 605                 610

 cag atg ctg gtg cca cat gga ctc cta ggc cct ggc cca ata gcc aat     2648
 Gln Met Leu Val Pro His Gly Leu Leu Gly Pro Gly Pro Ile Ala Asn
             615                 620                 625

 ggt ttc cca cca ggg ggt cct ggg ggc ccc aag ggc atg cag cac ttt     2696
 Gly Phe Pro Pro Gly Gly Pro Gly Gly Pro Lys Gly Met Gln His Phe
         630                 635                 640

 ccc cct gga cct ggg gga cct atg cca ggt ccc cat gga ggc cct ggt     2744
 Pro Pro Gly Pro Gly Gly Pro Met Pro Gly Pro His Gly Gly Pro Gly
     645                 650                 655

 ggg cca gtg ggt cca cgt ctt ctg ggt cct cca ccc cct ccc cgg gga     2792
 Gly Pro Val Gly Pro Arg Leu Leu Gly Pro Pro Pro Pro Pro Arg Gly
 660                 665                 670                 675

 ggt gat ccc ttc tgg gat ggc ccg ggc gac cct atg cgg ggt ggc cca     2840
 Gly Asp Pro Phe Trp Asp Gly Pro Gly Asp Pro Met Arg Gly Gly Pro
                 680                 685                 690

 atg cgg ggg ggt cca gga cca ggt cct gga cca tac cat aga ggc cga     2888
 Met Arg Gly Gly Pro Gly Pro Gly Pro Gly Pro Tyr His Arg Gly Arg
             695                 700                 705

 ggt ggc cga gga gga aac gaa cct cct cct cct cct cct cca ttc cga     2936
 Gly Gly Arg Gly Gly Asn Glu Pro Pro Pro Pro Pro Pro Pro Phe Arg
         710                 715                 720

 ggc gcc aga gga ggt cgc tct gga gga gga ccc cca aat gga cga ggg     2984
 Gly Ala Arg Gly Gly Arg Ser Gly Gly Gly Pro Pro Asn Gly Arg Gly
     725                 730                 735

 ggc cct ggt ggg ggc atg gtt gga ggt ggt ggg cat cgt cct cac gaa     3032
 Gly Pro Gly Gly Gly Met Val Gly Gly Gly Gly His Arg Pro His Glu
 740                 745                 750                 755

 ggc cct ggt ggg ggc atg ggc aac agc agt gga cat cgt ccc cac gaa     3080
 Gly Pro Gly Gly Gly Met Gly Asn Ser Ser Gly His Arg Pro His Glu
                 760                 765                 770

 ggc cct ggc ggt ggc atg gga agt ggg cat cgc ccc cat gaa ggc cct     3128
 Gly Pro Gly Gly Gly Met Gly Ser Gly His Arg Pro His Glu Gly Pro
             775                 780                 785

 ggt ggt agc atg ggt ggg ggt gga gga cat cgt ccc cac gaa ggc cct     3176
 Gly Gly Ser Met Gly Gly Gly Gly Gly His Arg Pro His Glu Gly Pro
         790                 795                 800

 ggc ggt ggc atc agt ggt ggc agt ggc cat cgt ccc cat gaa ggc cct     3224
 Gly Gly Gly Ile Ser Gly Gly Ser Gly His Arg Pro His Glu Gly Pro
     805                 810                 815

 ggc gga gga atg ggt gcc ggt ggt gga cat cgc ccc cac gaa ggc cct     3272
 Gly Gly Gly Met Gly Ala Gly Gly Gly His Arg Pro His Glu Gly Pro
 820                 825                 830                 835

 ggc gga agc atg ggt gga agt ggt gga cat cgt ccc cat gaa ggc cct     3320
 Gly Gly Ser Met Gly Gly Ser Gly Gly His Arg Pro His Glu Gly Pro
                 840                 845                 850

 gga cac ggg ggg ccc cat ggc cac cgg cct cat gat gtc cct ggt cac     3368
 Gly His Gly Gly Pro His Gly His Arg Pro His Asp Val Pro Gly His
             855                 860                 865

 cga ggc cat gac cat cga ggg ccg cca cct cat gag cac cgt ggc cat     3416
 Arg Gly His Asp His Arg Gly Pro Pro Pro His Glu His Arg Gly His
         870                 875                 880

 gat ggt cct ggc cac ggg gga ggg ggc cac cga ggg cac gat gga ggc     3464
 Asp Gly Pro Gly His Gly Gly Gly Gly His Arg Gly His Asp Gly Gly
     885                 890                 895

 cac agc cat gga gga gac atg tca aac cgc cct gtc tgc cga cat ttc     3512
 His Ser His Gly Gly Asp Met Ser Asn Arg Pro Val Cys Arg His Phe
 900                 905                 910                 915

 atg atg aag ggc aac tgc cgc tat gag aac aac tgt gcc ttc tac cac     3560
 Met Met Lys Gly Asn Cys Arg Tyr Glu Asn Asn Cys Ala Phe Tyr His
                 920                 925                 930

 ccg ggt gtc aat ggg ccc ccc ctg ccc taggg accatttgcc tgccctgttc     3612
 Pro Gly Val Asn Gly Pro Pro Leu Pro 
             935                 940

 acacaacccc tgtggactgc agcctcgctc tttccaccct gttatggctt ctgtgaggcc   3672

 cattttccct tttccccagc tgatgaggag ccggccccct cagttcccac ttgcttgggt   3732

 tcctgggggt tttctgatca ctggtgcgca ttgatgtaca tattttcctc cagtctgggg   3792

 aggagagaga ctggaaacgt tcctggactg ctgaagagga gacccagttg gcttcacttt   3852

 ttgagaagat tcgccctgta ccccaaaccc ctttccagta ttacccttaa tgcttgagaa   3912

 cctaaagctg gttatcctgg cgaacacccc tacccttcta ttgcgggtcc ccacatgcac   3972

 acagaactct gacacaggat cagctgcact taagaaatca tcccagctaa gttcattatt   4032

 cctcatgggg tggggagatg ctgaaagggg tattgtatat cccactgcac tgagagggct   4092

 caatcagctg gatttgagtt ctggaacaca catcatcccc acccctcccc cagcgtgggc   4152

 tcaccattct tagtcctttc tcaagtggga ccttcaactt tctgtgaaca cccagtctgc   4212

 gtcctgggtc tgctaggttc gatgatggcg aactcgtatc tgcatccggt gcaagtttta   4272

 gctggcagag gtgagaccgg tggtgctggt ctgcctttgc caactatagc cagtctggag   4332

 acttgataaa atacttcagt gagaccagct tctcatcaac ttgggcccgg cgtgctgggc   4392

 ctgaaagtca cactacatgc actgcctttg ggagtcagct cactccctgc tcccacctgg   4452

 aaccttgcca gcgtgaagga ggcttccagg tacttcaccc tgtcaaccac ctctgaatcc   4512

 ccaccaggcg ccttcctggg tggattcaac aagatgattt tgccctttcc cagttctctc   4572

 cttcactttg gcatcagttg ttttctatga aaacagtgga ttggttgggt tttgtgcagg   4632

 gtcttgggtt agagccaaaa tggatttgag gatgagtatt tttttttttg gttttgtata   4692

 ttttgtacat taataataaa cagtggaaag agaaaaaaaa aaaa                    4736




      <210> 176
      <211> 968
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (184)..(408)

      <220>
      <221> misc_feature
      <222> (1)...(968)
      <223> n = a,t,c or g

      <400> 176
 tttttttttt attattatac tttaagtttt agggtacatg tgcacaacgt gcaggtttgt     60

 tacatatgta tacatgtgcc atgttagtgt gctgcaccca ttaactcgtc atttagcatt    120

 aggtatatct cctacagcta tccctccccc cttcccccac cccacaaaag gtcccagtgt    180

 gtg  atg ttc ccc ttc ctg tgt cca tgt gtt ctc att gtt caa ttc cca     228
      Met Phe Pro Phe Leu Cys Pro Cys Val Leu Ile Val Gln Phe Pro
        1               5                  10                  15

 cct atg agt gag aac atg tgg gtt tgg ttt ttt tgt cct tgc gat agt      276
 Pro Met Ser Glu Asn Met Trp Val Trp Phe Phe Cys Pro Cys Asp Ser
                  20                  25                  30

 ttg ctg aga atg atg gtt tcc agc ttc atc cat gtc cct gcg aag gac      324
 Leu Leu Arg Met Met Val Ser Ser Phe Ile His Val Pro Ala Lys Asp
              35                  40                  45

 atg aac tca ccc ttt ttt atg gaa tac tac aca gcc ata aaa agg aat      372
 Met Asn Ser Pro Phe Phe Met Glu Tyr Tyr Thr Ala Ile Lys Arg Asn
          50                  55                  60

 gac aac aca tcc ctt gca ggg aca tgg atg gag caa tagg ccattatccg      422
 Asp Asn Thr Ser Leu Ala Gly Thr Trp Met Glu Gln 
      65                  70                  75

 tagcaaacta atgcaggaag agaaaaccca gtactgcatg ttctcactta taagtgggag    482

 ctaaatgatg agaacacatg aacacaaaga ggggaacaga cactagggcc gtttagaagt    542

 tggcgggtgg tttgcttttt tntttagnta cangatttat tagnaatggg tactaggctg    602

 aataccgttg tggatggtag taatcgggtg aacaaagcgc ccatgttcac aattttagct    662

 tattttttct ggttttcgtc atggtacccc ttgtgagtgt gagttatatg tttggttgat    722

 atttatcggt tattggattt ggtccctggg tggtgttttc gtggagtggt ggggttgttg    782

 tgattcttgt gtttggctgt ggtgtttaaa agaggtgtag gttggtgacc cgggtgttgt    842

 ccacgttatt ggctttgatg aggccccctt ttgtgggtgg tgtttggtgt tgttttggtc    902

 tggtcggtgg ccctatttgt gctttttgtt ggtagtggct tcctggtggt cggtgagcgg    962

 tgtgtt                                                               968




      <210> 177
      <211> 984
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (70)..(624)

      <400> 177
 ccaagtagag ctccgtcctg acgcgccgcc tcccgtgggc tccggccggc taagccgcgg     60

 cggacaact    atg ctg aaa gcc aag atc ctc ttc gtg ggg cct tgc gag     108
              Met Leu Lys Ala Lys Ile Leu Phe Val Gly Pro Cys Glu
                1               5                  10

 agt gga aaa act gtt ttg gcc aac ttt ctg aca gaa tct tct gac atc      156
 Ser Gly Lys Thr Val Leu Ala Asn Phe Leu Thr Glu Ser Ser Asp Ile
      15                  20                  25

 act gaa tac agc cca acc caa gga gtg agg atc cta gaa ttt gag aac      204
 Thr Glu Tyr Ser Pro Thr Gln Gly Val Arg Ile Leu Glu Phe Glu Asn
  30                  35                  40                  45

 ccg cat gtt acc agc aac aac aaa ggc acg ggc tgt gaa ttc gag cta      252
 Pro His Val Thr Ser Asn Asn Lys Gly Thr Gly Cys Glu Phe Glu Leu
                  50                  55                  60

 tgg gac tgt ggt ggc gat gct aag ttt gag tcc tgc tgg ccg gcc ctg      300
 Trp Asp Cys Gly Gly Asp Ala Lys Phe Glu Ser Cys Trp Pro Ala Leu
              65                  70                  75

 atg aag gat gct cat gga gtg gtg atc gtc ttc aat gct gac atc cca      348
 Met Lys Asp Ala His Gly Val Val Ile Val Phe Asn Ala Asp Ile Pro
          80                  85                  90

 agc cac cgg aag gaa atg gag atg tgg tat tcc tgc ttt gtc caa cag      396
 Ser His Arg Lys Glu Met Glu Met Trp Tyr Ser Cys Phe Val Gln Gln
      95                 100                 105

 ccg tcc tta cag gac aca cag tgt atg cta att gca cac cac aaa cca      444
 Pro Ser Leu Gln Asp Thr Gln Cys Met Leu Ile Ala His His Lys Pro
 110                 115                 120                 125

 ggc tct gga gat gat aaa gga agc ctg tct ttg tcg cca ccc ttg aac      492
 Gly Ser Gly Asp Asp Lys Gly Ser Leu Ser Leu Ser Pro Pro Leu Asn
                 130                 135                 140

 aag ctg aag ctg gtg cac tca aac ctg gaa gat gac cct gag gag atc      540
 Lys Leu Lys Leu Val His Ser Asn Leu Glu Asp Asp Pro Glu Glu Ile
             145                 150                 155

 cgg atg gaa ttc ata aag tat tta aaa agc ata atc aac tcc atg tct      588
 Arg Met Glu Phe Ile Lys Tyr Leu Lys Ser Ile Ile Asn Ser Met Ser
         160                 165                 170

 gag agc aga gac agg gag gag atg tca att atg acc tagc cagccttcac      638
 Glu Ser Arg Asp Arg Glu Glu Met Ser Ile Met Thr 
     175                 180                 185

 ctgggactgc cacatcccca gtgaaatcag catgtttctc ggtgcagatc tgaaatcaca    698

 tccagctcct gatgttttct tctccctctg actgcagagg aagtgttcct acctgcagga    758

 aggcacctgt cacacagggc gttcactcag accatctgtg ctctgccctg agttcagttg    818

 agaaaatcct attatcaaat ttggatttcc tggccccaga acttcccaaa gacctgtaaa    878

 atggagggat ttaccacctc acatatgtcc agttaaacag tttgtggact tgtaaccgtc    938

 gcagcccaat gatacaacag tagtttaatc acgtgaaaaa aaaaaa                   984




      <210> 178
      <211> 1517
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (666)..(1403)

      <220>
      <221> misc_feature
      <222> (1)...(1517)
      <223> n = a,t,c or g

      <400> 178
 ctcgaaatcg atactttgcc ggaccggnnc ggnnnnccgg ggtcgacggg aggcaggagg     60

 gccgacccag gggtgctggc cgccctctgt gagaaaactg acaatgacat ccgggcctgc    120

 atcaacaccc tgcagttcct gtacagccgg ggccagcggg agctgagcgt gcgggacgtg    180

 caggccacac gcgtgggcct caaggaccag cgcagagggc tcttctcggt gtggcaggag    240

 gtcttccagc tgcctcgagc ccagagcacc ccacctgcag gcgccgtgtg ggccaggacc    300

 ccgccctgcc tgctgacaca ctcctgctgg gtgacgggga cgcgggctcc ctcacctccg    360

 cctcacagcg attctaccgt gtcctgcatg ccgctgcctc tgcgggcgag cacgagaagg    420

 tggtccaggg cttgtttgac aacttcctgc gtctgcggct gcgagactcc agcctgggtg    480

 ctgtgtgtgt ggccctcgac tggctggcct tcgatgacct gctggcgggg gctgctcatc    540

 acagccagag cttccagctg ctgcgctacc cacccttcct gcccgtggcc ttccatgtgc    600

 tgtttgcttc cagccacaca cccaggatca ccttccccag cagccagcag gaggcccaga    660

 accgg    atg agc cag atg agg aac ctg atc cag acg ctg gtg tcc ggc     707
          Met Ser Gln Met Arg Asn Leu Ile Gln Thr Leu Val Ser Gly
            1               5                  10

 atc gcg cca gcc acg cgc agc cgg gcc acg ccc cag gcc ctg ctc ctc      755
 Ile Ala Pro Ala Thr Arg Ser Arg Ala Thr Pro Gln Ala Leu Leu Leu
  15                  20                  25                  30

 gat gcc ctc tgc ctg ctc ctg gac att ctt gcg ccc aag ctc cgc ccc      803
 Asp Ala Leu Cys Leu Leu Leu Asp Ile Leu Ala Pro Lys Leu Arg Pro
                  35                  40                  45

 gtg agc aca cag ctg tac agc acc cgt gaa aag caa cag ctg gcc agc      851
 Val Ser Thr Gln Leu Tyr Ser Thr Arg Glu Lys Gln Gln Leu Ala Ser
              50                  55                  60

 ctg gtg ggc acg atg ctc gct tac agc ctg acc tac cgc cag gag cgc      899
 Leu Val Gly Thr Met Leu Ala Tyr Ser Leu Thr Tyr Arg Gln Glu Arg
          65                  70                  75

 acg ccc gat ggc cag tac atc tac agg ctg gag ccg aac gtg gag gaa      947
 Thr Pro Asp Gly Gln Tyr Ile Tyr Arg Leu Glu Pro Asn Val Glu Glu
      80                  85                  90

 ctc tgc cgc ttc cct gag ctg cct gcc cgc aag ccc ctc acc tac cag      995
 Leu Cys Arg Phe Pro Glu Leu Pro Ala Arg Lys Pro Leu Thr Tyr Gln
  95                 100                 105                 110

 acg aag cag ctc atc gcc cgc gag atc gag gtg gag aag atg cgg cgg     1043
 Thr Lys Gln Leu Ile Ala Arg Glu Ile Glu Val Glu Lys Met Arg Arg
                 115                 120                 125

 gcg gag gct tct gcc cgg gta gag aac agc ccc cag gtg gat ggg agc     1091
 Ala Glu Ala Ser Ala Arg Val Glu Asn Ser Pro Gln Val Asp Gly Ser
             130                 135                 140

 ccc cca ggg ctc gag ggt ctg ctg ggg ggc att ggg gag aaa ggg gtg     1139
 Pro Pro Gly Leu Glu Gly Leu Leu Gly Gly Ile Gly Glu Lys Gly Val
         145                 150                 155

 cac cga cct gcc cca cgc aac cat gag cag cgg ctg gag cac atc atg     1187
 His Arg Pro Ala Pro Arg Asn His Glu Gln Arg Leu Glu His Ile Met
     160                 165                 170

 agg cga gcg gcc cgg gag gaa cag cct gag aag gac ttc ttt gga cgt     1235
 Arg Arg Ala Ala Arg Glu Glu Gln Pro Glu Lys Asp Phe Phe Gly Arg
 175                 180                 185                 190

 gtg gtc gtc agg agc aca gca gtc ccg agt gca ggg gac acg gcc ccg     1283
 Val Val Val Arg Ser Thr Ala Val Pro Ser Ala Gly Asp Thr Ala Pro
                 195                 200                 205

 gag cag gac tca gtg gag cgg cgc atg ggc aca gcg gtg ggc agg agc     1331
 Glu Gln Asp Ser Val Glu Arg Arg Met Gly Thr Ala Val Gly Arg Ser
             210                 215                 220

 gag gtc tgg ttc cgc ttc aac gag ggt gtc tcc aac gcc gtg cgg cgc     1379
 Glu Val Trp Phe Arg Phe Asn Glu Gly Val Ser Asn Ala Val Arg Arg
         225                 230                 235

 agc ctg tac atc agg gac ttg ctc tagttctctg agccgcggac atgccctcgc    1433
 Ser Leu Tyr Ile Arg Asp Leu Leu 
     240                 245

 attgcttccc gcagagtgca gagacaggaa gctggagatg tctttataaa gtcacacctt   1493

 tacagactgt aaaaaaaaaa aaaa                                          1517




      <210> 179
      <211> 585
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (498)..(569)

      <400> 179
 ttttgcctaa gatacaatga taagtaaaaa catgttacag agtaataacg tgttgcatag     60

 gacaatactg taaatgtggt tcattccatc aacagacact gagccctgcg acgtgcctgg    120

 ctctattcta catctgaggg acacaaggtg aacaagacca ggccactgta ttcaacatct    180

 acatttaatg gaaatttttg aaagaagact tgagagatta taacagtggt cttcagcatc    240

 agggagtagg cctagaagaa gaggaggtca agaagtggct tttcttatta tcttcttaac    300

 tcttcaaatt tttactatga gcaattatta ttttttatta aaattttagg ccaggcttat    360

 ggctgtaatc ctagcagttt gggaggccaa ggtgagcgga tcacttgagg ttgggagttc    420

 gagaccagcc tgaccaacat ggagaaactc tgtctctact taaaaaaaaa tacaaaatta    480

 gccaggcatg gtggcac   atg cct gta gtc cca gct act cag gag act gag     530
                      Met Pro Val Val Pro Ala Thr Gln Glu Thr Glu
                        1               5                  10

 gca ggg gaa ttg cct gaa cct ggg aga cag agg ttg caa tgagccaaga       579
 Ala Gly Glu Leu Pro Glu Pro Gly Arg Gln Arg Leu Gln 
              15                  20

 tcacgc                                                               585




      <210> 180
      <211> 1188
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (313)..(846)

      <400> 180
 aaggatcctt aattaaatta atcccccccc cccggggaga aacgttctca ctcgctctct     60

 gctcgctgcg ggcgctcccc gccctctgct gccagaacct tggggatgtg cctagacccg    120

 gcgcagcaca cgtccgggcc aaccgcgagc agaacaaacc tttggcgggc ggccaggagg    180

 ctccctccca gccaccgccc ccctccagcg cctttttttc cccccataca atacaagatc    240

 ttccttcctc agttccctta aagcacagcc cagggaaacc tcctcacagt tttcatccag    300

 ccacgggcca gc    atg tct ggg ggc aaa tac gta gac tcg gag gga cat     348
                  Met Ser Gly Gly Lys Tyr Val Asp Ser Glu Gly His
                    1               5                  10

 ctc tac acc gtt ccc atc cgg gaa cag ggc aac atc tac aag ccc aac      396
 Leu Tyr Thr Val Pro Ile Arg Glu Gln Gly Asn Ile Tyr Lys Pro Asn
          15                  20                  25

 aac aag gcc atg gca gac gag ctg agc gag aag caa gtg tac gac gcg      444
 Asn Lys Ala Met Ala Asp Glu Leu Ser Glu Lys Gln Val Tyr Asp Ala
      30                  35                  40

 cac acc aag gag atc gac ctg gtc aac cgc gac cct aaa cac ctc aac      492
 His Thr Lys Glu Ile Asp Leu Val Asn Arg Asp Pro Lys His Leu Asn
  45                  50                  55                  60

 gat gac gtg gtc aag att gac ttt gaa gat gtg att gca gaa cca gaa      540
 Asp Asp Val Val Lys Ile Asp Phe Glu Asp Val Ile Ala Glu Pro Glu
                  65                  70                  75

 ggg aca cac agt ttt gac ggc att tgg aag gcc agc ttc acc acc ttc      588
 Gly Thr His Ser Phe Asp Gly Ile Trp Lys Ala Ser Phe Thr Thr Phe
              80                  85                  90

 act gtg acg aaa tac tgg ttt tac cgc ttg ctg tct gcc ctc ttt ggc      636
 Thr Val Thr Lys Tyr Trp Phe Tyr Arg Leu Leu Ser Ala Leu Phe Gly
          95                 100                 105

 atc ccg atg gca ctc atc tgg ggc att tac ttc gcc att ctc tct ttc      684
 Ile Pro Met Ala Leu Ile Trp Gly Ile Tyr Phe Ala Ile Leu Ser Phe
     110                 115                 120

 ctg cac atc tgg gca gtt gta cca tgc att aag agc ttc ctg att gag      732
 Leu His Ile Trp Ala Val Val Pro Cys Ile Lys Ser Phe Leu Ile Glu
 125                 130                 135                 140

 att cag tgc atc agc cgt gtc tat tcc atc tac gtc cac acc gtc tgt      780
 Ile Gln Cys Ile Ser Arg Val Tyr Ser Ile Tyr Val His Thr Val Cys
                 145                 150                 155

 gac cca ctc ttt gaa gct gtt ggg aaa ata ttc agc aat gtc cgc atc      828
 Asp Pro Leu Phe Glu Ala Val Gly Lys Ile Phe Ser Asn Val Arg Ile
             160                 165                 170

 aac ttg cag aaa gaa ata taaatg acatttcaag gatagaagta tacctgattt      882
 Asn Leu Gln Lys Glu Ile 
         175

 tttttccttt taattttcct ggtgccaatt tcaagttcca agttgctaat acagcaacaa    942

 tttatgaatt gaattatctt ggttgaaaat aaaaagatca ctttctcagt tttcataagt   1002

 attatgtctc ttctgagcta tttcatctat ttttggcagt ctgaattttt aaaacccatt   1062

 taaatttttt tccttacctt tttatttgca tgtggatcaa ccatcgcttt attggctgag   1122

 atatgaacat attgttgaaa ggtaatttga gagaaatatg aagaactgag gaggaaaaaa   1182

 aaaaaa                                                              1188




      <210> 181
      <211> 870
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (465)..(644)

      <400> 181
 agacgggatt tcactatgtt ggtcaggctg gtctcgaact cccgaccgca agtgatccac     60

 ccgccttggc ctcccaaagt gctgggatta caagcttgag ccactgcacc cagcctggaa    120

 agtatattta tgaaaggttt gcactccaca aaagcatctt tgctagggtg tcaaggaaga    180

 gatcactaaa ccaaccccaa cacatccata caattccagc aatctagaga gggctggtcc    240

 ttttcctttt ctggattatt ttctgttctc agtaaaacaa gtatttactg tgatactgaa    300

 acactgggaa attaacactg attaagatat tttaaacact gagtcttaat tataacagaa    360

 ccagttttca tcagaatgct tttacgtcac attcagtgaa gtgttacgct aatatattct    420

 acagccctga agatagaaaa aaggtttctc tccaggtatg agat atg gta caa aaa     476
                                                  Met Val Gln Lys
                                                    1

 tac att ttt cca cat aca aaa gag aga aaa aaa caa aga cat gtg gcg      524
 Tyr Ile Phe Pro His Thr Lys Glu Arg Lys Lys Gln Arg His Val Ala
   5                  10                  15                  20

 ggt ggc gag ggg agg ccc aat ccc aac acc cta caa ggt tcc atg gaa      572
 Gly Gly Glu Gly Arg Pro Asn Pro Asn Thr Leu Gln Gly Ser Met Glu
                  25                  30                  35

 tgg aga agg aac aaa aaa atc ccc aat tat ttt ggg gta aga tgt gcc      620
 Trp Arg Arg Asn Lys Lys Ile Pro Asn Tyr Phe Gly Val Arg Cys Ala
              40                  45                  50

 cca gaa aag gtg aaa tct atg caa taaaacccag gttttcttca aatctagcat     674
 Pro Glu Lys Val Lys Ser Met Gln 
          55                  60

 ctaggatttc tatcagagtt tcaaataatc agaatttcta tcagaatttc taccctgagg    734

 tgacacctac taactgtagg ttctttcatt aaaaatgaag acatctttca ccagaatgta    794

 tcaagctata aaactggctt cagagcctac acttagccag agtggaaaaa aaaaatagtg    854

 catattttcg acagca                                                    870




      <210> 182
      <211> 1163
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (63)..(1049)

      <400> 182
 tgagtcggcg gctgatttag aaggaggttc aggctacggt gagccgaagc cacacaggag     60

 cc   atg gaa gtg gca gag ccc agc agc ccc act gaa gag gag gag gag     107
      Met Glu Val Ala Glu Pro Ser Ser Pro Thr Glu Glu Glu Glu Glu
        1               5                  10                  15

 gaa gag gag cac tcg gca gag cct cgg ccc cgc act cgc tcc aat cct      155
 Glu Glu Glu His Ser Ala Glu Pro Arg Pro Arg Thr Arg Ser Asn Pro
                  20                  25                  30

 gaa ggg gct gag gac cgg gca gta ggg gca cag gcc agc gtg ggc agc      203
 Glu Gly Ala Glu Asp Arg Ala Val Gly Ala Gln Ala Ser Val Gly Ser
              35                  40                  45

 cgc agc gag ggt gag ggt gag gcc gcc agt gct gat gat ggg agc ctc      251
 Arg Ser Glu Gly Glu Gly Glu Ala Ala Ser Ala Asp Asp Gly Ser Leu
          50                  55                  60

 aac act tca gga gcc ggc cct aag tcc tgg cag gtg ccc ccg cca gcc      299
 Asn Thr Ser Gly Ala Gly Pro Lys Ser Trp Gln Val Pro Pro Pro Ala
      65                  70                  75

 cct gag gtc caa att cgg aca cca agg gtc aac tgt cca gag aaa gtg      347
 Pro Glu Val Gln Ile Arg Thr Pro Arg Val Asn Cys Pro Glu Lys Val
  80                  85                  90                  95

 att atc tgc ctg gac ctg tca gag gaa atg tca ctg cca aag ctg gag      395
 Ile Ile Cys Leu Asp Leu Ser Glu Glu Met Ser Leu Pro Lys Leu Glu
                 100                 105                 110

 tcg ttc aac ggc tcc aaa acc aac gcc ctc aat gtc tcc cag aag atg      443
 Ser Phe Asn Gly Ser Lys Thr Asn Ala Leu Asn Val Ser Gln Lys Met
             115                 120                 125

 att gag atg ttc gtg cgg aca aaa cac aag atc gac aaa agc cac gag      491
 Ile Glu Met Phe Val Arg Thr Lys His Lys Ile Asp Lys Ser His Glu
         130                 135                 140

 ttt gca ctg gtg gtg gtg aac gat gac acg gcc tgg ctg tct ggc ctg      539
 Phe Ala Leu Val Val Val Asn Asp Asp Thr Ala Trp Leu Ser Gly Leu
     145                 150                 155

 acc tcc gac ccc cgc gag ctc tgt agc tgc ctc tat gat ctg gag acg      587
 Thr Ser Asp Pro Arg Glu Leu Cys Ser Cys Leu Tyr Asp Leu Glu Thr
 160                 165                 170                 175

 gcc tcc tgt tcc acc ttc aat ctg gaa gga ctt ttc agc ctc atc cag      635
 Ala Ser Cys Ser Thr Phe Asn Leu Glu Gly Leu Phe Ser Leu Ile Gln
                 180                 185                 190

 cag aaa act gag ctt ccg gtc aca gag aac gtg cag acg att ccc ccg      683
 Gln Lys Thr Glu Leu Pro Val Thr Glu Asn Val Gln Thr Ile Pro Pro
             195                 200                 205

 cca tat gtg gtc cgc acc atc ctt gtc tac agc cgt cca cct tgc cag      731
 Pro Tyr Val Val Arg Thr Ile Leu Val Tyr Ser Arg Pro Pro Cys Gln
         210                 215                 220

 ccc cag ttc tcc ttg acg gag ccc atg aag aaa atg ttc cag tgc cca      779
 Pro Gln Phe Ser Leu Thr Glu Pro Met Lys Lys Met Phe Gln Cys Pro
     225                 230                 235

 tat ttc ttc ttt gac gtt gtt tac atc cac aat ggc act gag gag aag      827
 Tyr Phe Phe Phe Asp Val Val Tyr Ile His Asn Gly Thr Glu Glu Lys
 240                 245                 250                 255

 gag gag gag atg agt tgg aag gat atg ttt gcc ttc atg ggc agc ctg      875
 Glu Glu Glu Met Ser Trp Lys Asp Met Phe Ala Phe Met Gly Ser Leu
                 260                 265                 270

 gat acc aag ggt acc agc tac aag tat gag gtg gca ctg gct ggg cca      923
 Asp Thr Lys Gly Thr Ser Tyr Lys Tyr Glu Val Ala Leu Ala Gly Pro
             275                 280                 285

 gcc ctg gag ttg cac aac tgc atg gcg aaa ctg ttg gcc cac ccc ctg      971
 Ala Leu Glu Leu His Asn Cys Met Ala Lys Leu Leu Ala His Pro Leu
         290                 295                 300

 cag cgg cct tgc cag agc cat gct tcc tac agc ctg ctg gag gag gag     1019
 Gln Arg Pro Cys Gln Ser His Ala Ser Tyr Ser Leu Leu Glu Glu Glu
     305                 310                 315

 gat gaa gcc att gag gtt gag gcc act gtc t gaaccatccc tgtacatctg     1070
 Asp Glu Ala Ile Glu Val Glu Ala Thr Val 
 320                 325

 caccttcttg tgcaaggaag tccttggcct aaagccttgg ttctcaaact gggttccttg   1130

 ggacctccgg ggtggggggg ttccaggagg cat                                1163




      <210> 183
      <211> 3768
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (144)..(2492)

      <400> 183
 aagggccaaa actacgactt ggctttctga aacggaagca taaatgttct tttcctccat     60

 ttgtctggat ctgagaacct gcatttggta ttagctagtg gaagcagtat gtatggttga    120

 agtgcattgc tgcagctggt agc    atg agt ggt ggc cac cag ctg cag ctg     170
                              Met Ser Gly Gly His Gln Leu Gln Leu
                                1               5

 gct gcc ctc tgg ccc tgg ctg ctg atg gct acc ctg cag gca ggc ttt      218
 Ala Ala Leu Trp Pro Trp Leu Leu Met Ala Thr Leu Gln Ala Gly Phe
  10                  15                  20                  25

 gga cgc aca gga ctg gta ctg gca gca gcg gtg gag tct gaa aga tca      266
 Gly Arg Thr Gly Leu Val Leu Ala Ala Ala Val Glu Ser Glu Arg Ser
                  30                  35                  40

 gca gaa cag aaa gct att atc aga gtg atc ccc ttg aaa atg gac ccc      314
 Ala Glu Gln Lys Ala Ile Ile Arg Val Ile Pro Leu Lys Met Asp Pro
              45                  50                  55

 aca gga aaa ctg aat ctc act ttg gaa ggt gtg ttt gct ggt gtt gct      362
 Thr Gly Lys Leu Asn Leu Thr Leu Glu Gly Val Phe Ala Gly Val Ala
          60                  65                  70

 gaa ata act cca gca gaa gga aaa tta atg cag tcc cac ccg ctg tac      410
 Glu Ile Thr Pro Ala Glu Gly Lys Leu Met Gln Ser His Pro Leu Tyr
      75                  80                  85

 ctg tgc aat gcc agt gat gac gac aat ctg gag cct gga ttc atc agc      458
 Leu Cys Asn Ala Ser Asp Asp Asp Asn Leu Glu Pro Gly Phe Ile Ser
  90                  95                 100                 105

 atc gtc aag ctg gag agt cct cga cgg gcc ccc cgc ccc tgc ctg tca      506
 Ile Val Lys Leu Glu Ser Pro Arg Arg Ala Pro Arg Pro Cys Leu Ser
                 110                 115                 120

 ctg gct agc aag gct cgg atg gcg ggt gag cga gga gcc agt gct gtc      554
 Leu Ala Ser Lys Ala Arg Met Ala Gly Glu Arg Gly Ala Ser Ala Val
             125                 130                 135

 ctc ttt gac atc act gag gat cga gct gct gct gag cag ctg cag cag      602
 Leu Phe Asp Ile Thr Glu Asp Arg Ala Ala Ala Glu Gln Leu Gln Gln
         140                 145                 150

 ccg ctg ggg ctg acc tgg cca gtg gtg ttg atc tgg ggt aat gac gct      650
 Pro Leu Gly Leu Thr Trp Pro Val Val Leu Ile Trp Gly Asn Asp Ala
     155                 160                 165

 gag aag ctg atg gag ttt gtg tac aag aac caa aag gcc cat gtg agg      698
 Glu Lys Leu Met Glu Phe Val Tyr Lys Asn Gln Lys Ala His Val Arg
 170                 175                 180                 185

 att gag ctg aag gag ccc ccg gcc tgg cca gat tat gat gtg tgg atc      746
 Ile Glu Leu Lys Glu Pro Pro Ala Trp Pro Asp Tyr Asp Val Trp Ile
                 190                 195                 200

 cta atg aca gtg gtg ggc acc atc ttt gtg atc atc ctg gct tcg gtg      794
 Leu Met Thr Val Val Gly Thr Ile Phe Val Ile Ile Leu Ala Ser Val
             205                 210                 215

 ctg cgc atc cgg tgc cgc ccc cgc cac agc agg ccg gat ccg ctt cag      842
 Leu Arg Ile Arg Cys Arg Pro Arg His Ser Arg Pro Asp Pro Leu Gln
         220                 225                 230

 cag aga aca gcc tgg gcc atc agc cag ctg gcc acc agg agg tac cag      890
 Gln Arg Thr Ala Trp Ala Ile Ser Gln Leu Ala Thr Arg Arg Tyr Gln
     235                 240                 245

 gcc agc tgc agg cag gcc cgg ggt gag tgg cca gac tca ggg agc agc      938
 Ala Ser Cys Arg Gln Ala Arg Gly Glu Trp Pro Asp Ser Gly Ser Ser
 250                 255                 260                 265

 tgc agc tca gcc cct gtg tgt gcc atc tgt ctg gag gag ttc tct gag      986
 Cys Ser Ser Ala Pro Val Cys Ala Ile Cys Leu Glu Glu Phe Ser Glu
                 270                 275                 280

 ggg cag gag cta cgg gtc att tcc tgc ctc cat gag ttc cat cgt aac     1034
 Gly Gln Glu Leu Arg Val Ile Ser Cys Leu His Glu Phe His Arg Asn
             285                 290                 295

 tgt gtg gac ccc tgg tta cat cag cat cgg act tgc ccc ctc tgc gtg     1082
 Cys Val Asp Pro Trp Leu His Gln His Arg Thr Cys Pro Leu Cys Val
         300                 305                 310

 ttc aac atc aca gag gga gat tca ttt tcc cag tcc ctg gga ccc tct     1130
 Phe Asn Ile Thr Glu Gly Asp Ser Phe Ser Gln Ser Leu Gly Pro Ser
     315                 320                 325

 cga tct tac caa gaa cca ggt cga aga ctc cac ctc att cgc cag cat     1178
 Arg Ser Tyr Gln Glu Pro Gly Arg Arg Leu His Leu Ile Arg Gln His
 330                 335                 340                 345

 ccc ggc cat gcc cac tac cac ctc cct gct gcc tac ctg ttg ggc cct     1226
 Pro Gly His Ala His Tyr His Leu Pro Ala Ala Tyr Leu Leu Gly Pro
                 350                 355                 360

 tcc cgg agt gca gtg gct cgg ccc cca cga cct ggt ccc ttc ctg cca     1274
 Ser Arg Ser Ala Val Ala Arg Pro Pro Arg Pro Gly Pro Phe Leu Pro
             365                 370                 375

 tcc cag gag cca ggc atg ggc cct cgg cat cac cgc ttc ccc aga gct     1322
 Ser Gln Glu Pro Gly Met Gly Pro Arg His His Arg Phe Pro Arg Ala
         380                 385                 390

 gca cat ccc cgg gct cca gga gag cag cag cgc ctg gca gga gcc cag     1370
 Ala His Pro Arg Ala Pro Gly Glu Gln Gln Arg Leu Ala Gly Ala Gln
     395                 400                 405

 cac ccc tat gca caa ggc tgg gga atg agc cac ctc caa tcc acc tca     1418
 His Pro Tyr Ala Gln Gly Trp Gly Met Ser His Leu Gln Ser Thr Ser
 410                 415                 420                 425

 cag cac cct gct gct tgc cca gtg ccc cta cgc cgg gcc agg ccc cct     1466
 Gln His Pro Ala Ala Cys Pro Val Pro Leu Arg Arg Ala Arg Pro Pro
                 430                 435                 440

 gac agc agt gga tct gga gaa agc tat tgc aca gaa cgc agt ggg tac     1514
 Asp Ser Ser Gly Ser Gly Glu Ser Tyr Cys Thr Glu Arg Ser Gly Tyr
             445                 450                 455

 ctg gca gat ggg cca gcc agt gac tcc agc tca ggg ccc tgt cat ggc     1562
 Leu Ala Asp Gly Pro Ala Ser Asp Ser Ser Ser Gly Pro Cys His Gly
         460                 465                 470

 tct tcc agt gac tct gtg gtc aac tgc acg gac atc agc cta cag ggg     1610
 Ser Ser Ser Asp Ser Val Val Asn Cys Thr Asp Ile Ser Leu Gln Gly
     475                 480                 485

 gtc cat ggc agc agt tct act ttc tgc agc tcc cta agc agt gac ttt     1658
 Val His Gly Ser Ser Ser Thr Phe Cys Ser Ser Leu Ser Ser Asp Phe
 490                 495                 500                 505

 gac ccc cta gtg tac tgc agc cct aaa ggg gat ccc cag cga gtg gac     1706
 Asp Pro Leu Val Tyr Cys Ser Pro Lys Gly Asp Pro Gln Arg Val Asp
                 510                 515                 520

 atg cag cct agt gtg acc tct cgg cct cgt tcc ttg gac tcg gtg gtg     1754
 Met Gln Pro Ser Val Thr Ser Arg Pro Arg Ser Leu Asp Ser Val Val
             525                 530                 535

 ccc aca ggg gaa acc cag gtt tcc agc cat gtc cac tac cac cgc cac     1802
 Pro Thr Gly Glu Thr Gln Val Ser Ser His Val His Tyr His Arg His
         540                 545                 550

 cgg cac cac cac tac aaa aag cgg ttc cag tgg cat ggc agg aag cct     1850
 Arg His His His Tyr Lys Lys Arg Phe Gln Trp His Gly Arg Lys Pro
     555                 560                 565

 ggc cca gaa acc gga gtc ccc cag tcc agg cct cct att cct cgg aca     1898
 Gly Pro Glu Thr Gly Val Pro Gln Ser Arg Pro Pro Ile Pro Arg Thr
 570                 575                 580                 585

 cag ccc cag cca gag cca cct tct cct gat cag caa gtc acc aga tcc     1946
 Gln Pro Gln Pro Glu Pro Pro Ser Pro Asp Gln Gln Val Thr Arg Ser
                 590                 595                 600

 aac tca gca gcc cct tcg ggg cgg ctc tct aac cca cag tgc ccc agg     1994
 Asn Ser Ala Ala Pro Ser Gly Arg Leu Ser Asn Pro Gln Cys Pro Arg
             605                 610                 615

 gcc ctc cct gag cca gcc cct ggc cca gtt gac gcc tcc agc atc tgc     2042
 Ala Leu Pro Glu Pro Ala Pro Gly Pro Val Asp Ala Ser Ser Ile Cys
         620                 625                 630

 ccc agt acc agc agt ctg ttc aac ttg caa aaa tcc agc ctc tct gcc     2090
 Pro Ser Thr Ser Ser Leu Phe Asn Leu Gln Lys Ser Ser Leu Ser Ala
     635                 640                 645

 cga cac cca cag agg aaa agg cgg ggg ggt ccc tcc gag ccc acc cct     2138
 Arg His Pro Gln Arg Lys Arg Arg Gly Gly Pro Ser Glu Pro Thr Pro
 650                 655                 660                 665

 ggc tct cgg ccc cag gat gca act gtg cac cca gct tgc cag att ttt     2186
 Gly Ser Arg Pro Gln Asp Ala Thr Val His Pro Ala Cys Gln Ile Phe
                 670                 675                 680

 ccc cat tac acc ccc agt gtg gca tat cct tgg tcc cca gag gca cac     2234
 Pro His Tyr Thr Pro Ser Val Ala Tyr Pro Trp Ser Pro Glu Ala His
             685                 690                 695

 ccc ttg atc tgt gga cct cca ggc ctg gac aag agg ctg cta cca gaa     2282
 Pro Leu Ile Cys Gly Pro Pro Gly Leu Asp Lys Arg Leu Leu Pro Glu
         700                 705                 710

 acc cca ggc ccc tgt tac tca aat tca cag cca gtg tgg ttg tgc ctg     2330
 Thr Pro Gly Pro Cys Tyr Ser Asn Ser Gln Pro Val Trp Leu Cys Leu
     715                 720                 725

 act cct cgc cag ccc ctg gaa cca cat cca cct ggg gag ggg cct tct     2378
 Thr Pro Arg Gln Pro Leu Glu Pro His Pro Pro Gly Glu Gly Pro Ser
 730                 735                 740                 745

 gaa tgg agt tct gac acc gca gag ggc agg cca tgc cct tat ccg cac     2426
 Glu Trp Ser Ser Asp Thr Ala Glu Gly Arg Pro Cys Pro Tyr Pro His
                 750                 755                 760

 tgc cag gtg ctg tcg gcc cag cct ggc tca gag gag gaa ctc gag gag     2474
 Cys Gln Val Leu Ser Ala Gln Pro Gly Ser Glu Glu Glu Leu Glu Glu
             765                 770                 775

 ctg tgt gaa cag gct gtg tgagat gttcaggcct agctccaacc aagagtgtgc     2528
 Leu Cys Glu Gln Ala Val 
         780

 tccagatgtg tttgggccct acctggcaca gagtcctgct cctgggaaag gaaaggacca   2588

 cagcaaacac cattcttttt gccgtacttc ctagaagcac tggaagagga ctggtgatgg   2648

 tggagggtga gagggtgccg tttcctgctc cagctccaga ccttgtctgc agaaaacatc   2708

 tgcagtgcag caaatccatg tccagccagg caaccagctg ctgcctgtgg cgtgtgtggg   2768

 ctggatccct tgaaggctga gtttttgagg gcagaaagct agctatgggt agccaggtgt   2828

 tacaaaggtg ctgctccttc tccaacccct acttggtttc cctcacccca agcctcatgt   2888

 tcataccagc caagtgggtt cagcagaaac gcatgacacc tttatcacct cccttccttg   2948

 ggtagagctc gtgagacacc agcgtttggc cccctccaca gtaaggctgc tacatcaggg   3008

 gcaaccctgg ctctatcatt ttcctttttt gccaaaagga ccagtagcat aggtgagccc   3068

 tgagcactaa aaggaggggt ccctgaagct ttcccactat agtgtggagt tctgtccctg   3128

 aggtgggtac agcagccttg gttcctctgg gggttgagaa taagaatagt ggggagggaa   3188

 aaactcctcc ttgaagattt cctgtctcag agtcccagag aggtagaaag gaggaatttc   3248

 tgctggactt tatctgggca gaggaaggat ggaatgaagg tagaaaaggc agaattacag   3308

 ctgagcgggg acaacaaaga gttcttctct gggaaaagtt ttgtcttaga gcaaggatgg   3368

 aaaatgggga caacaaagga aaagcaaagt gtgacccttg ggtttggaca gcccagaggc   3428

 ccagctcccc agtataagcc atacaggcca gggacccaca ggagagtgga ttagagcaca   3488

 agtctggcct cactgagtgg acaagagctg atgggcctca tcagggtgac attcacccca   3548

 gggcagcctg accactcttg gcccctcagg cattatccca tttggaatgt gaatgtggtg   3608

 gcaaagtggg cagaggaccc cacctgggaa cctttttccc tcagttagtg gggagactag   3668

 cacctaggta cccacatggg tatttatatc tgaaccagac agacgcttga atcaggcact   3728

 atgttaagaa atatatttat ttgctaatat atttatccac                         3768




      <210> 184
      <211> 2794
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (266)..(2575)

      <400> 184
 gaagaatctt tccatgccgc tggagctcat ctgctccgat gagcacatgc aaggcagcgg     60

 gagcctggcc caggctgtca tcagggaagt cagagcccag tggagtcgga ttttctccac    120

 cgcactcttc gtggagcacg tgctcctagg aaccgagagc cgcgtccccg agttacaggg    180

 gctggtgacc gagcacgtct tcttactaga caagtgtctt cgagagaact ctgacgtgaa    240

 gacgcacggg ccttttgagg ccgtg  atg cgc act ctc tgt gaa tgc aag gag     292
                              Met Arg Thr Leu Cys Glu Cys Lys Glu
                                1               5

 aca gcc agc aag acc ctc agc agg ttt ggg att cag ccg tgc tcc atc      340
 Thr Ala Ser Lys Thr Leu Ser Arg Phe Gly Ile Gln Pro Cys Ser Ile
  10                  15                  20                  25

 tgc ctg gga gat gca aag gac ccc gtc tgt ctg ccc tgc gac cac gtg      388
 Cys Leu Gly Asp Ala Lys Asp Pro Val Cys Leu Pro Cys Asp His Val
                  30                  35                  40

 cac tgc ctg cgc tgc ctc agg gcc tgg ttt gcc tca gag cag atg ata      436
 His Cys Leu Arg Cys Leu Arg Ala Trp Phe Ala Ser Glu Gln Met Ile
              45                  50                  55

 tgc ccc tac tgt tta act gcc ttg cca gac gaa ttc tct cca gct gtt      484
 Cys Pro Tyr Cys Leu Thr Ala Leu Pro Asp Glu Phe Ser Pro Ala Val
          60                  65                  70

 tcc caa gcg cac agg gaa gcc att gaa aag cat gcc cgc ttc cgg cag      532
 Ser Gln Ala His Arg Glu Ala Ile Glu Lys His Ala Arg Phe Arg Gln
      75                  80                  85

 atg tgc aac agt ttc ttc gta gac ctg gtg tcc acc att tgc ttc aag      580
 Met Cys Asn Ser Phe Phe Val Asp Leu Val Ser Thr Ile Cys Phe Lys
  90                  95                 100                 105

 gac aac gct ccg cct gag aag gaa gtg att gag agc ctg ctc tct ctc      628
 Asp Asn Ala Pro Pro Glu Lys Glu Val Ile Glu Ser Leu Leu Ser Leu
                 110                 115                 120

 ctc ttc gtc caa aag ggg cgc tta aga gat gct gcc cag aga cac tgt      676
 Leu Phe Val Gln Lys Gly Arg Leu Arg Asp Ala Ala Gln Arg His Cys
             125                 130                 135

 gaa cac aca aaa tct ctc tct cca ttc aat gat gtt gtg gat aag act      724
 Glu His Thr Lys Ser Leu Ser Pro Phe Asn Asp Val Val Asp Lys Thr
         140                 145                 150

 cct gtc atc cgc tca gtg ata ctg aaa ctg ctt ttg aag tac agc ttt      772
 Pro Val Ile Arg Ser Val Ile Leu Lys Leu Leu Leu Lys Tyr Ser Phe
     155                 160                 165

 cat gat gta aaa gat tat att cag gaa tat ttg acc ctg tta aaa aag      820
 His Asp Val Lys Asp Tyr Ile Gln Glu Tyr Leu Thr Leu Leu Lys Lys
 170                 175                 180                 185

 aaa gca ttc ata act gaa gat aaa act gaa ctg tac atg ctc ttc atc      868
 Lys Ala Phe Ile Thr Glu Asp Lys Thr Glu Leu Tyr Met Leu Phe Ile
                 190                 195                 200

 aac tgc ctg gag gat tca ata ctt gag aag acc agt gct tac tcc aga      916
 Asn Cys Leu Glu Asp Ser Ile Leu Glu Lys Thr Ser Ala Tyr Ser Arg
             205                 210                 215

 aat gat gaa ctg aac cac cta gaa gag gaa ggt cgt ttc ctt aag gca      964
 Asn Asp Glu Leu Asn His Leu Glu Glu Glu Gly Arg Phe Leu Lys Ala
         220                 225                 230

 tat tct cca gca agc cgg ggc cga gag cct gcc aac gag gcc tcg gtt     1012
 Tyr Ser Pro Ala Ser Arg Gly Arg Glu Pro Ala Asn Glu Ala Ser Val
     235                 240                 245

 gaa tac ctg caa gag gtg gcc cgg atc cgc ctc tgc ctc gac aga gct     1060
 Glu Tyr Leu Gln Glu Val Ala Arg Ile Arg Leu Cys Leu Asp Arg Ala
 250                 255                 260                 265

 gca gat ttc ctc tcg ggg cct gag gga ggc cca gag atg gcc aag gag     1108
 Ala Asp Phe Leu Ser Gly Pro Glu Gly Gly Pro Glu Met Ala Lys Glu
                 270                 275                 280

 aag cag tgc tac ctg cag caa gtc aag cag ttc tgt atc cgg gtg gag     1156
 Lys Gln Cys Tyr Leu Gln Gln Val Lys Gln Phe Cys Ile Arg Val Glu
             285                 290                 295

 aac gac tgg cac cgg gtg tac ctg gtg cgg aag ctc agc agc cag cgg     1204
 Asn Asp Trp His Arg Val Tyr Leu Val Arg Lys Leu Ser Ser Gln Arg
         300                 305                 310

 ggg atg gag ttc gtg cag ggc ctc tcc aag ccc ggc cgc ccg cac cag     1252
 Gly Met Glu Phe Val Gln Gly Leu Ser Lys Pro Gly Arg Pro His Gln
     315                 320                 325

 tgg gtg ttt ccc aag gac gtt gtc aag cag cag ggg ctg cgg cag gac     1300
 Trp Val Phe Pro Lys Asp Val Val Lys Gln Gln Gly Leu Arg Gln Asp
 330                 335                 340                 345

 cac cca ggc cag atg gat agg tac ctg gtg tac ggc gat gaa tac aag     1348
 His Pro Gly Gln Met Asp Arg Tyr Leu Val Tyr Gly Asp Glu Tyr Lys
                 350                 355                 360

 gct ctc cgt gat gct gtg gcc aaa gct gtc ctc gag tgc aag cca ctg     1396
 Ala Leu Arg Asp Ala Val Ala Lys Ala Val Leu Glu Cys Lys Pro Leu
             365                 370                 375

 ggc att aag act gct ctg aag gcc tgc aag acc ccc caa agc cag cag     1444
 Gly Ile Lys Thr Ala Leu Lys Ala Cys Lys Thr Pro Gln Ser Gln Gln
         380                 385                 390

 tca gcc tac ttc ctg tta aca ctg ttt aga gag gtg gct att ttg tac     1492
 Ser Ala Tyr Phe Leu Leu Thr Leu Phe Arg Glu Val Ala Ile Leu Tyr
     395                 400                 405

 aga tcc cac aat gca agc ctc cac ccc acg cca gag caa tgt gaa gct     1540
 Arg Ser His Asn Ala Ser Leu His Pro Thr Pro Glu Gln Cys Glu Ala
 410                 415                 420                 425

 gtg agc aaa ttc att ggc gaa tgc aag atc ctt tca cct cct gat atc     1588
 Val Ser Lys Phe Ile Gly Glu Cys Lys Ile Leu Ser Pro Pro Asp Ile
                 430                 435                 440

 agc cgt ttt gca aca tcg ctc gtg gac aat tct gtg cca ttg ttg agg     1636
 Ser Arg Phe Ala Thr Ser Leu Val Asp Asn Ser Val Pro Leu Leu Arg
             445                 450                 455

 gcg ggg cct agt gac agc aac ctt gat gga acg gtg aca gaa atg gcc     1684
 Ala Gly Pro Ser Asp Ser Asn Leu Asp Gly Thr Val Thr Glu Met Ala
         460                 465                 470

 att cat gct gca gcc gtc ctt ctg tgt gga cag aat gaa ctc ttg gag     1732
 Ile His Ala Ala Ala Val Leu Leu Cys Gly Gln Asn Glu Leu Leu Glu
     475                 480                 485

 ccc cta aag aat ctg gcc ttc tcc cca gcc acc atg gcg cat gct ttt     1780
 Pro Leu Lys Asn Leu Ala Phe Ser Pro Ala Thr Met Ala His Ala Phe
 490                 495                 500                 505

 ctt cca acc atg cct gaa gac ttg ctg gct caa gct cgg agg tgg aag     1828
 Leu Pro Thr Met Pro Glu Asp Leu Leu Ala Gln Ala Arg Arg Trp Lys
                 510                 515                 520

 ggt ctg gag cga gtc cac tgg tac act tgt ccc aac ggc cat cct tgc     1876
 Gly Leu Glu Arg Val His Trp Tyr Thr Cys Pro Asn Gly His Pro Cys
             525                 530                 535

 tcc gtg gga gag tgt ggc agg ccg atg gaa cag agc atc tgc att gac     1924
 Ser Val Gly Glu Cys Gly Arg Pro Met Glu Gln Ser Ile Cys Ile Asp
         540                 545                 550

 tgc cat gcg ccg att gga ggc att gac cac aaa cct cgg gac ggc ttt     1972
 Cys His Ala Pro Ile Gly Gly Ile Asp His Lys Pro Arg Asp Gly Phe
     555                 560                 565

 cat ctg gtc aaa gac aag gca gac aga acg cag acc ggc cat gtg ctg     2020
 His Leu Val Lys Asp Lys Ala Asp Arg Thr Gln Thr Gly His Val Leu
 570                 575                 580                 585

 ggc aac ccg cag cgg aga gac gtg gtg aca tgt gac cga ggg ctg ccc     2068
 Gly Asn Pro Gln Arg Arg Asp Val Val Thr Cys Asp Arg Gly Leu Pro
                 590                 595                 600

 cca gtg gtc ttc ctc ctt atc cgg cta ctc act cac ttg gct ctg ctt     2116
 Pro Val Val Phe Leu Leu Ile Arg Leu Leu Thr His Leu Ala Leu Leu
             605                 610                 615

 ctg gga gcg tcc cag agt tcc cag gct ctg ata aac atc att aag cct     2164
 Leu Gly Ala Ser Gln Ser Ser Gln Ala Leu Ile Asn Ile Ile Lys Pro
         620                 625                 630

 cca gtg agg gat cca aaa ggc ttt ctg cag cag cac atc ctg aag gac     2212
 Pro Val Arg Asp Pro Lys Gly Phe Leu Gln Gln His Ile Leu Lys Asp
     635                 640                 645

 ctg gag cag ttg gcc aag atg ctg gga cac agt gcc gac gag acc atc     2260
 Leu Glu Gln Leu Ala Lys Met Leu Gly His Ser Ala Asp Glu Thr Ile
 650                 655                 660                 665

 ggc gtg gtc cac ctc gtc ctg cgc agg ctt ctc caa gag cag cac cag     2308
 Gly Val Val His Leu Val Leu Arg Arg Leu Leu Gln Glu Gln His Gln
                 670                 675                 680

 ctc tct agc aga agt gag gaa agg ggc aag ggc tgg gcg ggg atc aca     2356
 Leu Ser Ser Arg Ser Glu Glu Arg Gly Lys Gly Trp Ala Gly Ile Thr
             685                 690                 695

 cag cac aac ggc agc gca agc agg ctc gct gtc ttg tgg gcc acc cca     2404
 Gln His Asn Gly Ser Ala Ser Arg Leu Ala Val Leu Trp Ala Thr Pro
         700                 705                 710

 cac aca gcc agt ctg agc tct gtc tgt gct gtt gct gga aag aat gag     2452
 His Thr Ala Ser Leu Ser Ser Val Cys Ala Val Ala Gly Lys Asn Glu
     715                 720                 725

 aga aca cac aga gag aaa acc gtg tct agg gaa ggc gat gcc tgg ggc     2500
 Arg Thr His Arg Glu Lys Thr Val Ser Arg Glu Gly Asp Ala Trp Gly
 730                 735                 740                 745

 tgg aaa aag gaa gca ctc tgc ttg ccc aga ggc tgg aag gag ctg ctc     2548
 Trp Lys Lys Glu Ala Leu Cys Leu Pro Arg Gly Trp Lys Glu Leu Leu
                 750                 755                 760

 tgt tcc ctc cat tca ccc ctg cct ggc taaga cctgcggtat tcgggagcgt     2600
 Cys Ser Leu His Ser Pro Leu Pro Gly 
             765                 770

 ctgcacgcaa gtgttcagtg tgcatatatg gggagtcttc agttccgaag tcagccacgt   2660

 aggtcattcc cctaccatgc tgggagcacg tgtcgtccac acagagcgtg cgtgtcaaag   2720

 gatcaatcac catcacagtt gtgtgctgat ttattaaatg tttatatgtc cacagttatg   2780

 ttaaaaaaaa aaaa                                                     2794




      <210> 185
      <211> 819
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (310)..(564)

      <400> 185
 cattttgaac aacttttatt atacgtttag tgttctctat acaaaagaaa tcagtttttt     60

 tacagtgatt caaaaaaaat tcagaataat ttggcctttt cattgctcat gcagtcagtt    120

 tataagtcca tgtattagac ggccctccat ggcccagaag tcttccctgc tgaaggtcgt    180

 gtgtgacacc ctcagatacg catctgtcac tgacaaagtt ggttaatgca aaataactcg    240

 caaaaaagga aagaacatga tgtgagaggg gttaaaacaa ggtctggcat ggagttaaat    300

 gtttaacca    atg gaa aaa aga tca gac caa ttt gtg tgt gtg tgg ata     348
              Met Glu Lys Arg Ser Asp Gln Phe Val Cys Val Trp Ile
                1               5                  10

 tgt agg aag gga tgg aga cgc tgg gaa aaa aaa ttc ccc acg gga aag      396
 Cys Arg Lys Gly Trp Arg Arg Trp Glu Lys Lys Phe Pro Thr Gly Lys
      15                  20                  25

 aac aaa ttg gaa tgg tgg ggg ata tgg gtg tgt ggt ggg ggc ggg gca      444
 Asn Lys Leu Glu Trp Trp Gly Ile Trp Val Cys Gly Gly Gly Gly Ala
  30                  35                  40                  45

 gga ggt cct ccg ggg tcc agc atg ggt cgg gag tgg gag cag gac aga      492
 Gly Gly Pro Pro Gly Ser Ser Met Gly Arg Glu Trp Glu Gln Asp Arg
                  50                  55                  60

 agg tgg cca cgt cac agg cga ctg atg ctc agc tca agt gcc cca gga      540
 Arg Trp Pro Arg His Arg Arg Leu Met Leu Ser Ser Ser Ala Pro Gly
              65                  70                  75

 gac agc ctc gtc tgg tcg ggc acc tgagtcagag ccatcaaact cctgggctgt     594
 Asp Ser Leu Val Trp Ser Gly Thr 
          80                  85

 gttgatgtaa acagcgtagt cggccccgtt ccgcatgagg ttggcattgg caatgtggtg    654

 cttgaccacg cccccgccca gaatgatcat cccagtgcac ttggcaaaga tggcctgtgt    714

 gttgatgagc ctcaggtcct caacgatgtc caggaccagg cccgggttct tgtaggaatg    774

 gaagaagatc atgtcgccca gcgagccgcc cgggaattcc ggacc                    819




      <210> 186
      <211> 726
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (32)..(691)

      <400> 186
 cggccgtgtg gcgcggctgc tcgccccact a   atg tgg cgc agg gcg gtt tcc      52
                                      Met Trp Arg Arg Ala Val Ser
                                        1               5

 tcg gtg gcg ggg tcc gcg gtt gga gcc gag ccc ggg ctt cgg ctg ctg      100
 Ser Val Ala Gly Ser Ala Val Gly Ala Glu Pro Gly Leu Arg Leu Leu
          10                  15                  20

 gcc gtg cag cgg ctt ccc gta gga gca gcg ttc tgc cgg gct tgc cag      148
 Ala Val Gln Arg Leu Pro Val Gly Ala Ala Phe Cys Arg Ala Cys Gln
      25                  30                  35

 acc cca aac ttt gtc cgc ggc ctg cac agc gag cct ggg ctg gag gag      196
 Thr Pro Asn Phe Val Arg Gly Leu His Ser Glu Pro Gly Leu Glu Glu
  40                  45                  50                  55

 cgg gcg gag ggg acg gtc aac gag gga cgc cca gaa tcg gac gcg gca      244
 Arg Ala Glu Gly Thr Val Asn Glu Gly Arg Pro Glu Ser Asp Ala Ala
                  60                  65                  70

 gat cat act ggt ccc aag ttt gac atc gat atg atg gtt tca ctt ctg      292
 Asp His Thr Gly Pro Lys Phe Asp Ile Asp Met Met Val Ser Leu Leu
              75                  80                  85

 agg caa gaa aat gca aga gac att tgt gtg atc cag gtt cct cca gaa      340
 Arg Gln Glu Asn Ala Arg Asp Ile Cys Val Ile Gln Val Pro Pro Glu
          90                  95                 100

 atg aga tat aca gat tac ttt gtg att gtt agt gga act tct acc cga      388
 Met Arg Tyr Thr Asp Tyr Phe Val Ile Val Ser Gly Thr Ser Thr Arg
     105                 110                 115

 cac tta cat gcc atg gcc ttc tac gtt gtg aaa atg tac aaa cac ctg      436
 His Leu His Ala Met Ala Phe Tyr Val Val Lys Met Tyr Lys His Leu
 120                 125                 130                 135

 aaa tgt aaa cgt gac cct cat gtt aag ata gaa ggg aag gac act gat      484
 Lys Cys Lys Arg Asp Pro His Val Lys Ile Glu Gly Lys Asp Thr Asp
                 140                 145                 150

 gac tgg ctg tgc gtg gat ttt ggc agc atg gtg att cat ttg atg ctt      532
 Asp Trp Leu Cys Val Asp Phe Gly Ser Met Val Ile His Leu Met Leu
             155                 160                 165

 cca gaa acc aga gaa atc tat gaa tta gag aaa tta tgg acc cta cgt      580
 Pro Glu Thr Arg Glu Ile Tyr Glu Leu Glu Lys Leu Trp Thr Leu Arg
         170                 175                 180

 tct tat gat gac cag tta gct cag ata gca cct gag aca gta cct gaa      628
 Ser Tyr Asp Asp Gln Leu Ala Gln Ile Ala Pro Glu Thr Val Pro Glu
     185                 190                 195

 gac ttc att ctt gga ata gaa gat gat act tca tct gtg act cca gtg      676
 Asp Phe Ile Leu Gly Ile Glu Asp Asp Thr Ser Ser Val Thr Pro Val
 200                 205                 210                 215

 gag tta aaa tgt gaa taaaatattt tatgcactgc gttaaaaaaa aaaaa           726
 Glu Leu Lys Cys Glu 
                 220





      <210> 187
      <211> 1051
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (271)..(783)

      <400> 187
 ggagaggatg ggcatggcaa ataaaagcag gtcattcact cttttttctc atcaccctct     60

 aacttccttt tgattccctc actctttctg tgttcttttt tccttcccta attcttcacc    120

 tccccctcct ctgctgcctc cttgctctcc tcgcaggtca agtttaccca tgggggaact    180

 ggttccagcc aaaccgcacc aacctgtggc agggaaagtt ccccaaggga gacaaagctg    240

 aggatggctt ccatggagtc tccccagtga     atg ctt tcc ccg ccc aga aca     291
                                      Met Leu Ser Pro Pro Arg Thr
                                        1               5

 act acg ggc tct atg acc tcc tgg gga acg tgt ggg agt gga cag cat      339
 Thr Thr Gly Ser Met Thr Ser Trp Gly Thr Cys Gly Ser Gly Gln His
          10                  15                  20

 cac cgt acc agg ctg ctg agc agg aca tgc gcg tcc tcc ggg ggg cat      387
 His Arg Thr Arg Leu Leu Ser Arg Thr Cys Ala Ser Ser Gly Gly His
      25                  30                  35

 cct gga tcg aca cag ctg atg gct ctg cca atc acc ggg ccc ggg tca      435
 Pro Gly Ser Thr Gln Leu Met Ala Leu Pro Ile Thr Gly Pro Gly Ser
  40                  45                  50                  55

 cca cca gga tgg gca aca ctc cag att cag cct cag aca acc tcg gtt      483
 Pro Pro Gly Trp Ala Thr Leu Gln Ile Gln Pro Gln Thr Thr Ser Val
                  60                  65                  70

 tcc gct gtg ctg cag acg cag gcc ggc cgc cag ggg agc tgt aag cag      531
 Ser Ala Val Leu Gln Thr Gln Ala Gly Arg Gln Gly Ser Cys Lys Gln
              75                  80                  85

 ccg ggt ggt gac aag gag aaa agc ctt cta ggg tca ctg tca ttc cct      579
 Pro Gly Gly Asp Lys Glu Lys Ser Leu Leu Gly Ser Leu Ser Phe Pro
          90                  95                 100

 ggc cat gtt gca aac agc gca att cca agc tcg aga gct tca gcc tca      627
 Gly His Val Ala Asn Ser Ala Ile Pro Ser Ser Arg Ala Ser Ala Ser
     105                 110                 115

 gga aag aac ttc ccc ttc cct gtc tcc cat ccc tct gtg gca ggc gcc      675
 Gly Lys Asn Phe Pro Phe Pro Val Ser His Pro Ser Val Ala Gly Ala
 120                 125                 130                 135

 tct cac cag ggc agg aga gga ctc agc ctc ctg tgt ttt gga gaa ggg      723
 Ser His Gln Gly Arg Arg Gly Leu Ser Leu Leu Cys Phe Gly Glu Gly
                 140                 145                 150

 gcc caa tgt gtg ttg acg atg gct ggg ggc cag gtg ttt ctg tta gag      771
 Ala Gln Cys Val Leu Thr Met Ala Gly Gly Gln Val Phe Leu Leu Glu
             155                 160                 165

 gcc aag tat tat tga cacaggattg caaacacaca aacaattgga acagagcact      826
 Ala Lys Tyr Tyr 
         170

 ctgaaaggcc attttttaag cattttaaaa tctattctct ccccctttct ccctggatga    886

 ttcaggaagc tgacattgtt tcctcaaggc agaattttcc tggttctgtt ttctcagcca    946

 gttgctgtgg aaggagaatg ctttctttgt ggcctcatct gtggtttcgt gtccctctga   1006

 aggaaactag tttccactgt gtaacaggca gacatgtaac tattg                   1051




      <210> 188
      <211> 470
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (245)..(403)

      <400> 188
 taaagtaaca gcaccaactg tgtccccacg cagggaagaa atgaggtcgc agtaacttcc     60

 tgctggatcc tgatcttcag gggcactttt aagtggacgg ttgacttaat aatgggggaa    120

 attataatta aagtaccaca gaatcctcag aaaagacacc aggccattat ccctatttct    180

 atttgtcgta aaagttattg gctagaaact cacctaagtt tccaagccag agcactgtca    240

 ttaa atg gtg gct ttc tgt atc aaa gac caa ggt cat gtg gcc tgt cag     289
      Met Val Ala Phe Cys Ile Lys Asp Gln Gly His Val Ala Cys Gln
        1               5                  10                  15

 caa ggg cag ggg cct cgc tcc caa ccc gcc aga ggg ctg ggc ggc tcc      337
 Gln Gly Gln Gly Pro Arg Ser Gln Pro Ala Arg Gly Leu Gly Gly Ser
                  20                  25                  30

 tca gcc cct ccg cgg ctc ccg ggc tcc cgc cag ggt ctc ccg agg aca      385
 Ser Ala Pro Pro Arg Leu Pro Gly Ser Arg Gln Gly Leu Pro Arg Thr
              35                  40                  45

 ccc tcc tgg gtg aaa tgt taacag tggcgaactg tggagagctc cacattcctg      439
 Pro Ser Trp Val Lys Cys 
          50

 cagcctggag ctagtgacca gccctgaggc t                                   470


      <210> 189
      <211> 359
      <212> PRT
      <213> Homo sapiens


      <400> 189
 Met Phe Arg Met Asn Phe Met Lys Pro Leu Thr Gln Cys Ile Thr Val
   1               5                  10                  15    
 Gly His Glu Met Ser Lys Ala Ile Ala Ile Ala Gln Phe Asn Asp Asp
              20                  25                  30        
 Ser Pro Lys Ala Arg Lys Ile Pro Arg Arg Trp Arg Ile Gly Lys Ala
          35                  40                  45            
 Ala Asp Leu Val Gly Val Ser Ser Gln Ala Ile Arg Asp Ala Glu Lys
      50                  55                  60                
 Ala Gly Arg Leu Pro His Pro Asp Met Glu Ile Arg Gly Arg Val Glu
  65                  70                  75                  80
 Gln Arg Val Gly Tyr Thr Ile Glu Gln Ile Asn His Met Arg His Val
                  85                  90                  95    
 Phe Gly Pro Arg Leu Gln Arg Ala Glu Asn Val Phe Pro Pro Val Leu
             100                 105                 110        
 Gly Val Ala Ala His Lys Gly Gly Val Tyr Lys Thr Ser Val Ser Val
         115                 120                 125            
 His Leu Ala Gln Asp Leu Ala Leu Lys Gly Leu Arg Val Leu Leu Val
     130                 135                 140                
 Glu Gly Asn Asp Pro Gln Gly Thr Ala Ser Met Tyr His Gly Trp Val
 145                 150                 155                 160
 Pro Asp Leu His Ile His Ala Glu Asp Thr Leu Leu Pro Phe Tyr Leu
                 165                 170                 175    
 Gly Glu Lys Asp Asp Val Thr Tyr Ala Ile Lys Pro Thr Cys Trp Pro
             180                 185                 190        
 Gly Leu Asp Ile Ile Pro Ser Cys Leu Ala Leu His Arg Ile Glu Thr
         195                 200                 205            
 Glu Leu Met Gly Lys Phe Asp Glu Gly Lys Leu Pro Thr Asp Pro His
     210                 215                 220                
 Leu Met Leu Arg Leu Ala Ile Glu Thr Val Ala His Asp Tyr Asp Val
 225                 230                 235                 240
 Ile Val Ile Asp Ser Ala Pro Asn Leu Gly Ile Gly Thr Ile Asn Val
                 245                 250                 255    
 Val Cys Ala Ala Asp Val Leu Ile Val Pro Thr Pro Ala Glu Leu Phe
             260                 265                 270        
 Asp Tyr Thr Ser Ala Leu Gln Phe Phe Asp Met Leu Arg Asp Leu Leu
         275                 280                 285            
 Lys Asn Val Asp Leu Lys Gly Phe Glu Pro Asp Val Arg Ile Leu Leu
     290                 295                 300                
 Thr Lys Tyr Ser Asn Ser Asn Gly Ser Gln Ser Pro Trp Met Glu Glu
 305                 310                 315                 320
 Gln Ile Arg Asp Ala Trp Gly Ser Met Val Leu Lys Asn Val Val Arg
                 325                 330                 335    
 Glu Thr Asp Glu Val Gly Lys Gly Gln Ile Asn Asn His Arg Ala Thr
             340                 345                 350        
 Gly Gly Asn Phe Arg Leu
         355            



      <210> 190
      <211> 152
      <212> PRT
      <213> Homo sapiens


      <400> 190
 Met Gly Arg Met His Ala Pro Gly Lys Gly Leu Ser Gln Ser Ala Leu
   1               5                  10                  15    
 Pro Tyr Arg Arg Ser Val Pro Thr Trp Leu Lys Leu Thr Ser Asp Asp
              20                  25                  30        
 Val Lys Glu Gln Ile Tyr Lys Leu Ala Lys Lys Gly Leu Thr Pro Ser
          35                  40                  45            
 Gln Ile Gly Val Ile Leu Arg Asp Ser His Gly Val Ala Gln Val Arg
      50                  55                  60                
 Phe Val Thr Gly Asn Lys Ile Leu Arg Ile Leu Lys Ser Lys Gly Leu
  65                  70                  75                  80
 Ala Pro Asp Leu Pro Glu Asp Leu Tyr His Leu Ile Lys Lys Ala Val
                  85                  90                  95    
 Ala Val Arg Lys His Leu Glu Arg Asn Arg Lys Asp Lys Asp Ala Lys
             100                 105                 110        
 Phe Arg Leu Ile Leu Ile Glu Ser Arg Ile His Arg Leu Ala Arg Tyr
         115                 120                 125            
 Tyr Lys Thr Lys Arg Val Leu Pro Pro Asn Trp Lys Tyr Glu Ser Ser
     130                 135                 140                
 Thr Ala Ser Ala Leu Val Ala
 145                 150    



      <210> 191
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 191
 Met Pro Gly Val Thr Val Lys Asp Val Asn Gln Gln Glu Phe Val Arg
   1               5                  10                  15    
 Ala Leu Ala Ala Phe Leu Lys Lys Ser Gly Lys Leu Lys Val Pro Glu
              20                  25                  30        
 Trp Val Asp Thr Val Lys Leu Ala Lys His Lys Glu Leu Ala Pro Tyr
          35                  40                  45            
 Asp Glu Asn Trp Phe Tyr Thr Arg Ala Ala Ser Thr Ala Arg His Leu
      50                  55                  60                
 Tyr Leu Arg Gly Gly Ala Gly Val Gly Ser Met Thr Lys Ile Tyr Gly
  65                  70                  75                  80
 Gly Arg Gln Arg Asn Gly Val Met Pro Ser His Phe Ser Arg Gly Ser
                  85                  90                  95    
 Lys Ser Val Ala Arg Arg Val Leu Gln Ala Leu Glu Gly Leu Lys Met
             100                 105                 110        
 Val Glu Lys Asp Gln Asp Gly Gly Arg Lys Leu Thr Pro Gln Gly Gln
         115                 120                 125            
 Arg Asp Leu Asp Arg Ile Ala Gly Gln Val Ala Ala Ala Asn Lys Lys
     130                 135                 140                
 His
 145



      <210> 192
      <211> 616
      <212> PRT
      <213> Homo sapiens


      <400> 192
 Met Asp Ser Val Ala Phe Glu Asp Val Ala Val Asn Phe Thr His Glu
   1               5                  10                  15    
 Glu Trp Ala Leu Leu Gly Pro Ser Gln Lys Asn Leu Tyr Arg Asp Val
              20                  25                  30        
 Met Arg Glu Thr Ile Arg Asn Leu Asn Cys Ile Gly Met Lys Trp Glu
          35                  40                  45            
 Asn Gln Asn Ile Asp Asp Gln His Gln Asn Leu Arg Arg Asn Pro Arg
      50                  55                  60                
 Cys Asp Val Val Glu Arg Phe Gly Lys Ser Lys Asp Gly Ser Gln Cys
  65                  70                  75                  80
 Gly Glu Thr Leu Ser Gln Ile Arg Asn Ser Ile Val Asn Lys Asn Thr
                  85                  90                  95    
 Pro Ala Arg Val Asp Ala Cys Gly Ser Ser Val Asn Gly Glu Val Ile
             100                 105                 110        
 Met Gly His Ser Ser Leu Asn Cys Tyr Ile Arg Val Asp Thr Gly His
         115                 120                 125            
 Lys His Arg Glu Cys His Glu Tyr Ala Glu Lys Ser Tyr Thr His Lys
     130                 135                 140                
 Gln Cys Gly Lys Gly Leu Ser Tyr Arg His Ser Phe Gln Thr Cys Glu
 145                 150                 155                 160
 Arg Pro His Ala Gly Lys Lys Pro Tyr Asp Cys Lys Glu Cys Gly Lys
                 165                 170                 175    
 Thr Phe Ser Ser Pro Gly Asn Leu Arg Arg His Met Val Val Lys Gly
             180                 185                 190        
 Gly Asp Gly Pro Tyr Lys Cys Glu Leu Cys Gly Lys Ala Phe Phe Trp
         195                 200                 205            
 Pro Ser Leu Leu Arg Met His Glu Arg Thr His Thr Gly Glu Lys Pro
     210                 215                 220                
 Tyr Glu Cys Lys Gln Cys Ser Lys Ala Phe Pro Val Tyr Ser Ser Tyr
 225                 230                 235                 240
 Leu Arg His Glu Lys Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys
                 245                 250                 255    
 Gln Cys Ser Lys Ala Phe Pro Asp Tyr Ser Ser Tyr Leu Arg His Glu
             260                 265                 270        
 Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Gln Trp Gly Lys
         275                 280                 285            
 Ala Phe Ser Val Ser Gly Ser Leu Arg Val His Glu Arg Ile His Thr
     290                 295                 300                
 Gly Glu Lys Pro Tyr Thr Cys Lys Gln Cys Gly Lys Ala Phe Cys His
 305                 310                 315                 320
 Leu Gly Ser Phe Gln Arg His Met Ile Met His Ser Gly Asp Gly Pro
                 325                 330                 335    
 His Lys Cys Lys Ile Cys Gly Lys Gly Phe Asp Phe Pro Gly Ser Ala
             340                 345                 350        
 Arg Ile His Glu Gly Thr His Thr Leu Glu Lys Pro Tyr Glu Cys Lys
         355                 360                 365            
 Gln Cys Gly Lys Leu Leu Ser His Arg Ser Ser Phe Arg Arg His Met
     370                 375                 380                
 Met Ala His Thr Gly Asp Gly Pro His Lys Cys Thr Val Cys Gly Lys
 385                 390                 395                 400
 Ala Phe Asp Ser Pro Ser Val Phe Gln Arg His Glu Arg Thr His Thr
                 405                 410                 415    
 Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala Phe Arg Thr
             420                 425                 430        
 Ser Ser Ser Leu Arg Lys His Glu Thr Thr His Thr Gly Glu Gln Pro
         435                 440                 445            
 Tyr Lys Cys Lys Cys Gly Lys Ala Phe Ser Asp Leu Phe Ser Phe Gln
     450                 455                 460                
 Ser His Glu Thr Thr His Ser Glu Glu Glu Pro Tyr Glu Cys Lys Glu
 465                 470                 475                 480
 Cys Gly Lys Ala Phe Ser Ser Phe Lys Tyr Phe Cys Arg His Glu Arg
                 485                 490                 495    
 Thr His Ser Glu Glu Lys Ser Tyr Glu Cys Gln Ile Cys Gly Lys Ala
             500                 505                 510        
 Phe Ser Arg Phe Ser Tyr Leu Lys Thr His Glu Arg Thr His Thr Ala
         515                 520                 525            
 Glu Lys Pro Tyr Glu Cys Lys Gln Cys Arg Lys Ala Phe Phe Trp Pro
     530                 535                 540                
 Ser Phe Leu Leu Arg His Glu Arg Thr His Thr Gly Glu Arg Pro Tyr
 545                 550                 555                 560
 Glu Cys Lys His Cys Gly Lys Ala Phe Ser Arg Ser Ser Phe Cys Arg
                 565                 570                 575    
 Glu His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu
             580                 585                 590        
 Cys Gly Lys Ala Phe Ser Ser Leu Ser Ser Phe Asn Arg His Lys Arg
         595                 600                 605            
 Thr His Trp Lys Asp Ile Leu
     610                 615



      <210> 193
      <211> 202
      <212> PRT
      <213> Homo sapiens


      <400> 193
 Met Asn Pro Glu Tyr Asp Tyr Leu Phe Lys Leu Leu Leu Ile Gly Asp
   1               5                  10                  15    
 Ser Gly Val Gly Lys Ser Cys Leu Leu Leu Arg Phe Ala Asp Asp Thr
              20                  25                  30        
 Tyr Thr Glu Ser Tyr Ile Ser Thr Ile Gly Val Asp Phe Lys Ile Arg
          35                  40                  45            
 Thr Ile Glu Leu Asp Gly Lys Thr Ile Lys Leu Gln Ile Trp Asp Thr
      50                  55                  60                
 Ala Gly Gln Glu Arg Phe Arg Thr Ile Thr Ser Ser Tyr Tyr Arg Gly
  65                  70                  75                  80
 Ala His Gly Ile Ile Val Val Tyr Asp Val Thr Asp Gln Glu Ser Tyr
                  85                  90                  95    
 Ala Asn Val Lys Gln Trp Leu Gln Glu Ile Asp Arg Tyr Ala Ser Glu
             100                 105                 110        
 Asn Val Asn Lys Leu Leu Val Gly Asn Lys Ser Asp Leu Thr Thr Lys
         115                 120                 125            
 Lys Val Val Asp Asn Thr Thr Ala Lys Glu Phe Ala Asp Ser Leu Gly
     130                 135                 140                
 Ile Pro Phe Leu Glu Thr Ser Ala Lys Asn Ala Thr Asn Val Glu Gln
 145                 150                 155                 160
 Ala Phe Met Thr Met Ala Ala Glu Ile Lys Lys Arg Met Gly Pro Gly
                 165                 170                 175    
 Ala Ala Ser Gly Gly Glu Arg Pro Asn Leu Lys Ile Asp Ser Thr Pro
             180                 185                 190        
 Val Lys Pro Ala Gly Gly Gly Cys Cys
         195                 200    



      <210> 194
      <211> 667
      <212> PRT
      <213> Homo sapiens


      <400> 194
 Met Lys Leu Val Trp Pro Ser Ala Lys Leu Leu Gln Ala Ala Ala Gly
   1               5                  10                  15    
 Ala Ser Ala Arg Ala Cys Asp Ser Asp Thr Ser Asn Val Pro Pro Leu
              20                  25                  30        
 Leu Leu Glu Gln Phe Arg Lys His Ser Gln Ser Ser Gln Arg Arg Thr
          35                  40                  45            
 Ile Leu Glu Met Leu Leu Gly Phe Leu Lys Leu Gln Gln Lys Trp Ser
      50                  55                  60                
 Tyr Glu Asp Lys Asp Gln Arg Pro Leu Asn Gly Phe Lys Asp Gln Leu
  65                  70                  75                  80
 Cys Ser Leu Val Phe Met Ala Leu Thr Asp Pro Ser Thr Gln Leu Gln
                  85                  90                  95    
 Leu Val Gly Ile Arg Thr Leu Thr Val Leu Gly Ala Gln Pro Asp Leu
             100                 105                 110        
 Leu Ser Tyr Glu Asp Leu Glu Leu Ala Val Gly His Leu Tyr Arg Leu
         115                 120                 125            
 Ser Phe Leu Lys Glu Asp Ser Gln Ser Cys Arg Val Ala Ala Leu Glu
     130                 135                 140                
 Ala Ser Gly Thr Leu Ala Ala Leu Tyr Pro Val Ala Phe Ser Ser His
 145                 150                 155                 160
 Leu Val Pro Lys Leu Ala Glu Glu Leu Arg Val Gly Glu Ser Asn Leu
                 165                 170                 175    
 Thr Asn Gly Asp Glu Pro Thr Gln Cys Ser Arg His Leu Cys Cys Leu
             180                 185                 190        
 Gln Ala Leu Ser Ala Val Ser Thr His Pro Ser Ile Val Lys Glu Thr
         195                 200                 205            
 Leu Pro Leu Leu Leu Gln His Leu Trp Gln Val Asn Arg Gly Asn Met
     210                 215                 220                
 Val Ala Gln Ser Ser Asp Val Ile Ala Val Cys Gln Ser Leu Arg Gln
 225                 230                 235                 240
 Met Ala Glu Lys Cys Gln Gln Asp Pro Glu Ser Cys Trp Tyr Phe His
                 245                 250                 255    
 Gln Thr Ala Ile Pro Cys Leu Leu Ala Leu Ala Val Gln Ala Ser Met
             260                 265                 270        
 Pro Glu Lys Glu Pro Ser Val Leu Arg Lys Val Leu Leu Glu Asp Glu
         275                 280                 285            
 Val Leu Ala Ala Met Val Ser Val Ile Gly Thr Ala Thr Thr His Leu
     290                 295                 300                
 Ser Pro Glu Leu Ala Ala Gln Ser Val Thr His Ile Val Pro Leu Phe
 305                 310                 315                 320
 Leu Asp Gly Asn Val Ser Phe Leu Pro Glu Asn Ser Phe Pro Ser Arg
                 325                 330                 335    
 Phe Gln Pro Phe Gln Asp Gly Ser Ser Gly Gln Arg Arg Leu Ile Ala
             340                 345                 350        
 Leu Leu Met Ala Phe Val Cys Ser Leu Pro Arg Asn Val Glu Ile Pro
         355                 360                 365            
 Gln Leu Asn Gln Leu Met Arg Glu Leu Leu Glu Leu Ser Cys Cys His
     370                 375                 380                
 Ser Cys Pro Phe Ser Ser Thr Ala Ala Ala Lys Cys Phe Ala Gly Leu
 385                 390                 395                 400
 Leu Asn Lys His Pro Ala Gly Gln Gln Leu Asp Glu Phe Leu Gln Leu
                 405                 410                 415    
 Ala Val Asp Lys Val Glu Ala Gly Leu Asp Ser Gly Pro Cys Arg Ser
             420                 425                 430        
 Gln Ala Phe Thr Leu Leu Leu Trp Val Thr Lys Ala Leu Val Leu Arg
         435                 440                 445            
 Tyr His Pro Leu Ser Ser Cys Leu Thr Ala Arg Leu Met Gly Leu Leu
     450                 455                 460                
 Ser Asp Pro Glu Leu Gly Pro Ala Ala Ala Asp Gly Phe Ser Leu Leu
 465                 470                 475                 480
 Met Ser Asp Cys Thr Asp Val Leu Thr Arg Ala Gly His Ala Glu Val
                 485                 490                 495    
 Arg Ile Met Phe Arg Gln Arg Phe Phe Thr Asp Asn Val Pro Ala Leu
             500                 505                 510        
 Val Gln Gly Phe His Ala Ala Pro Gln Asp Val Lys Pro Asn Tyr Leu
         515                 520                 525            
 Lys Gly Leu Ser His Val Leu Asn Arg Leu Pro Lys Pro Val Leu Leu
     530                 535                 540                
 Pro Glu Leu Pro Thr Leu Leu Ser Leu Leu Leu Glu Ala Leu Ser Cys
 545                 550                 555                 560
 Pro Asp Cys Val Val Gln Leu Ser Thr Leu Ser Cys Leu Gln Pro Leu
                 565                 570                 575    
 Leu Leu Glu Ala Pro Gln Val Met Ser Leu His Val Asp Thr Leu Val
             580                 585                 590        
 Thr Lys Phe Leu Asn Leu Ser Ser Ser Pro Ser Met Ala Val Arg Ile
         595                 600                 605            
 Ala Ala Leu Gln Cys Met His Ala Leu Thr Arg Leu Pro Thr Pro Val
     610                 615                 620                
 Leu Leu Pro Tyr Lys Pro Gln Val Ile Arg Ala Leu Ala Lys Pro Leu
 625                 630                 635                 640
 Asp Asp Lys Lys Arg Leu Val Arg Lys Glu Ala Val Ser Ala Arg Gly
                 645                 650                 655    
 Glu Trp Phe Leu Leu Gly Ser Pro Gly Ser
             660                 665    



      <210> 195
      <211> 349
      <212> PRT
      <213> Homo sapiens


      <400> 195
 Met Pro Gly Trp Arg Leu Leu Thr Gln Val Gly Ala Gln Val Leu Gly
   1               5                  10                  15    
 Arg Leu Gly Asp Gly Leu Gly Ala Ala Leu Gly Pro Gly Asn Arg Thr
              20                  25                  30        
 His Ile Trp Leu Phe Val Arg Gly Leu His Gly Lys Ser Gly Thr Trp
          35                  40                  45            
 Trp Asp Glu His Leu Ser Glu Glu Asn Val Pro Phe Ile Lys Gln Leu
      50                  55                  60                
 Val Ser Asp Glu Asp Lys Ala Gln Leu Ala Ser Lys Leu Cys Pro Leu
  65                  70                  75                  80
 Lys Asp Glu Pro Trp Pro Ile His Pro Trp Glu Pro Gly Ser Phe Arg
                  85                  90                  95    
 Val Gly Leu Ile Ala Leu Lys Leu Gly Met Met Pro Leu Trp Thr Lys
             100                 105                 110        
 Asp Gly Gln Lys His Val Val Thr Leu Leu Gln Val Gln Asp Cys His
         115                 120                 125            
 Val Leu Lys Tyr Thr Ser Lys Glu Asn Cys Asn Gly Lys Met Ala Thr
     130                 135                 140                
 Leu Ser Val Gly Gly Lys Thr Val Ser Arg Phe Arg Lys Ala Thr Ser
 145                 150                 155                 160
 Ile Leu Glu Phe Tyr Arg Glu Leu Gly Leu Pro Pro Lys Gln Thr Val
                 165                 170                 175    
 Lys Ile Phe Asn Ile Thr Asp Asn Ala Ala Ile Lys Pro Gly Thr Pro
             180                 185                 190        
 Leu Tyr Ala Ala His Phe Arg Pro Gly Gln Tyr Val Asp Val Thr Ala
         195                 200                 205            
 Lys Thr Ile Gly Lys Gly Phe Gln Gly Val Met Lys Arg Trp Gly Phe
     210                 215                 220                
 Lys Gly Gln Pro Ala Thr His Gly Gln Thr Lys Thr His Arg Arg Pro
 225                 230                 235                 240
 Gly Ala Val Ala Thr Gly Asp Ile Gly Arg Val Trp Pro Gly Thr Lys
                 245                 250                 255    
 Met Pro Gly Lys Met Gly Asn Ile Tyr Arg Thr Glu Tyr Gly Leu Lys
             260                 265                 270        
 Val Trp Arg Ile Asn Thr Lys His Asn Ile Ile Tyr Val Asn Gly Ser
         275                 280                 285            
 Val Pro Gly His Lys Asn Cys Leu Val Lys Val Lys Asp Ser Lys Leu
     290                 295                 300                
 Pro Ala Tyr Lys Asp Leu Gly Lys Asn Leu Pro Phe Pro Thr Tyr Phe
 305                 310                 315                 320
 Pro Asp Gly Asp Glu Glu Glu Leu Pro Glu Asp Leu Tyr Asp Glu Asn
                 325                 330                 335    
 Val Cys Gln Pro Gly Ala Pro Ser Ile Thr Phe Ala
             340                 345            



      <210> 196
      <211> 138
      <212> PRT
      <213> Homo sapiens


      <400> 196
 Met Phe His Phe Phe Arg Lys Pro Pro Glu Ser Lys Lys Pro Ser Val
   1               5                  10                  15    
 Pro Glu Thr Glu Ala Asp Gly Phe Val Leu Leu Gly Asp Thr Thr Asp
              20                  25                  30        
 Glu Gln Arg Met Thr Ala Arg Gly Lys Thr Ser Asp Ile Glu Ala Asn
          35                  40                  45            
 Gln Pro Leu Glu Thr Asn Lys Glu Asn Ser Ser Ser Val Thr Val Ser
      50                  55                  60                
 Asp Pro Glu Met Glu Asn Lys Ala Gly Gln Thr Leu Glu Asn Ser Ser
  65                  70                  75                  80
 Leu Met Ala Glu Leu Leu Ser Asp Val Pro Phe Thr Leu Ala Pro His
                  85                  90                  95    
 Val Leu Ala Val Gln Gly Thr Ile Thr Asp Leu Pro Asp His Leu Leu
             100                 105                 110        
 Ser Tyr Asp Gly Ser Glu Asn Leu Ser Arg Phe Trp Tyr Asp Phe Thr
         115                 120                 125            
 Leu Glu Asn Ser Val Leu Cys Asp Ser
     130                 135        



      <210> 197
      <211> 1164
      <212> PRT
      <213> Homo sapiens


      <400> 197
 Met Asn Arg Glu Asp Arg Asn Val Leu Arg Met Lys Glu Arg Glu Arg
   1               5                  10                  15    
 Arg Asn Gln Glu Ile Gln Gln Gly Glu Asp Ala Phe Pro Pro Ser Ser
              20                  25                  30        
 Pro Leu Phe Ala Glu Pro Tyr Lys Val Thr Ser Lys Glu Asp Lys Leu
          35                  40                  45            
 Ser Ser Arg Ile Gln Ser Met Leu Gly Asn Tyr Asp Val Met Lys Asp
      50                  55                  60                
 Phe Ile Gly Asp Arg Ser Ile Pro Lys Leu Val Ala Ile Pro Lys Pro
  65                  70                  75                  80
 Thr Val Pro Pro Ser Ala Asp Glu Lys Ser Asn Pro Asn Phe Phe Glu
                  85                  90                  95    
 Gln Arg His Gly Gly Ser His Gln Ser Ser Lys Trp Thr Pro Val Gly
             100                 105                 110        
 Pro Ala Pro Ser Thr Ser Gln Ser Gln Lys Arg Ser Ser Gly Leu Gln
         115                 120                 125            
 Ser Gly His Ser Ser Gln Arg Thr Ser Ala Gly Ser Ser Ser Gly Thr
     130                 135                 140                
 Asn Ser Ser Gly Gln Arg His Asp Arg Glu Ser Tyr Asn Asn Ser Gly
 145                 150                 155                 160
 Ser Ser Ser Arg Lys Lys Gly Gln His Gly Ser Glu His Ser Lys Ser
                 165                 170                 175    
 Arg Ser Ser Ser Pro Gly Lys Pro Gln Ala Val Ser Ser Leu Asn Ser
             180                 185                 190        
 Ser His Ser Arg Ser His Gly Asn Asp His His Ser Lys Glu His Gln
         195                 200                 205            
 Arg Ser Lys Ser Pro Arg Asp Pro Asp Ala Asn Trp Asp Ser Pro Ser
     210                 215                 220                
 Arg Val Pro Phe Ser Ser Gly Gln His Ser Thr Gln Ser Phe Pro Pro
 225                 230                 235                 240
 Ser Leu Met Ser Lys Ser Asn Ser Met Leu Gln Lys Pro Thr Ala Tyr
                 245                 250                 255    
 Val Arg Pro Met Asp Gly Gln Glu Ser Met Glu Pro Lys Leu Ser Ser
             260                 265                 270        
 Glu His Tyr Ser Ser Gln Ser His Gly Asn Ser Met Thr Glu Leu Lys
         275                 280                 285            
 Pro Ser Ser Lys Ala His Leu Thr Lys Leu Lys Ile Pro Ser Gln Pro
     290                 295                 300                
 Leu Asp Ala Ser Ala Ser Gly Asp Val Ser Cys Val Asp Glu Ile Leu
 305                 310                 315                 320
 Lys Glu Met Thr His Ser Trp Pro Pro Pro Leu Thr Ala Ile His Thr
                 325                 330                 335    
 Pro Cys Lys Thr Glu Pro Ser Lys Phe Pro Phe Pro Thr Lys Glu Ser
             340                 345                 350        
 Gln Gln Ser Asn Phe Gly Thr Gly Glu Gln Lys Arg Tyr Asn Pro Ser
         355                 360                 365            
 Lys Thr Ser Asn Gly His Gln Ser Lys Ser Met Leu Lys Asp Asp Leu
     370                 375                 380                
 Lys Leu Ser Ser Ser Glu Asp Ser Asp Gly Glu Gln Asp Cys Asp Lys
 385                 390                 395                 400
 Thr Met Pro Arg Ser Thr Pro Gly Ser Asn Ser Glu Pro Ser His His
                 405                 410                 415    
 Asn Ser Glu Gly Ala Asp Asn Ser Arg Asp Asp Ser Ser Ser His Ser
             420                 425                 430        
 Gly Ser Glu Ser Ser Ser Gly Ser Asp Ser Glu Ser Glu Ser Ser Ser
         435                 440                 445            
 Ser Asp Ser Glu Ala Asn Glu Pro Ser Gln Ser Ala Ser Pro Glu Pro
     450                 455                 460                
 Glu Pro Pro Pro Thr Asn Lys Trp Gln Leu Asp Asn Trp Leu Asn Lys
 465                 470                 475                 480
 Val Asn Pro His Lys Val Ser Pro Ala Ser Ser Val Asp Ser Asn Ile
                 485                 490                 495    
 Pro Ser Ser Gln Gly Tyr Lys Lys Glu Gly Arg Glu Gln Gly Thr Gly
             500                 505                 510        
 Asn Ser Tyr Thr Asp Thr Ser Gly Pro Lys Glu Thr Ser Ser Ala Thr
         515                 520                 525            
 Pro Gly Arg Asp Ser Lys Thr Ile Gln Lys Gly Ser Glu Ser Gly Arg
     530                 535                 540                
 Gly Arg Gln Lys Ser Pro Ala Gln Ser Asp Ser Thr Thr Gln Arg Arg
 545                 550                 555                 560
 Thr Val Gly Lys Lys Gln Pro Lys Lys Ala Glu Lys Ala Ala Ala Glu
                 565                 570                 575    
 Glu Pro Arg Gly Gly Leu Lys Ile Glu Ser Glu Thr Pro Val Asp Leu
             580                 585                 590        
 Ala Ser Ser Met Pro Ser Ser Arg His Lys Ala Ala Thr Lys Gly Ser
         595                 600                 605            
 Arg Lys Pro Asn Ile Lys Lys Glu Ser Lys Ser Ser Pro Arg Pro Thr
     610                 615                 620                
 Ala Glu Lys Lys Lys Tyr Lys Ser Thr Ser Lys Ser Ser Gln Lys Ser
 625                 630                 635                 640
 Arg Glu Ile Ile Glu Thr Asp Thr Ser Ser Ser Asp Ser Asp Glu Ser
                 645                 650                 655    
 Glu Ser Leu Pro Pro Ser Ser Gln Thr Pro Lys Tyr Pro Glu Ser Asn
             660                 665                 670        
 Arg Thr Pro Val Lys Pro Ser Ser Val Glu Glu Glu Asp Ser Phe Phe
         675                 680                 685            
 Arg Gln Arg Met Phe Ser Pro Met Glu Glu Lys Glu Leu Leu Ser Pro
     690                 695                 700                
 Leu Ser Glu Pro Asp Asp Arg Tyr Pro Leu Ile Val Lys Ile Asp Leu
 705                 710                 715                 720
 Asn Leu Leu Thr Arg Ile Pro Gly Lys Pro Tyr Lys Glu Thr Glu Pro
                 725                 730                 735    
 Pro Lys Gly Glu Lys Lys Asn Val Pro Glu Lys His Thr Arg Glu Ala
             740                 745                 750        
 Gln Lys Gln Ala Ser Glu Lys Val Ser Asn Lys Gly Lys Arg Lys His
         755                 760                 765            
 Lys Asn Glu Asp Asp Asn Arg Ala Ser Glu Ser Lys Lys Pro Lys Thr
     770                 775                 780                
 Glu Asp Lys Asn Ser Ala Gly His Lys Pro Ser Ser Asn Arg Glu Ser
 785                 790                 795                 800
 Ser Lys Gln Ser Ala Ala Lys Glu Lys Asp Leu Leu Pro Ser Pro Ala
                 805                 810                 815    
 Gly Pro Val Pro Ser Lys Asp Pro Lys Thr Glu His Gly Ser Arg Lys
             820                 825                 830        
 Arg Thr Ile Ser Gln Ser Ser Ser Leu Lys Ser Ser Ser Asn Ser Asn
         835                 840                 845            
 Lys Glu Thr Ser Gly Ser Ser Lys Asn Ser Ser Ser Thr Ser Lys Gln
     850                 855                 860                
 Lys Lys Thr Glu Gly Lys Thr Ser Ser Ser Ser Lys Glu Val Lys Glu
 865                 870                 875                 880
 Lys Ala Pro Ser Ser Ser Ser Asn Cys Pro Pro Ser Ala Pro Thr Leu
                 885                 890                 895    
 Asp Ser Ser Lys Pro Arg Arg Thr Lys Leu Val Phe Asp Asp Arg Asn
             900                 905                 910        
 Tyr Ser Ala Asp His Tyr Leu Gln Glu Ala Lys Lys Leu Lys His Asn
         915                 920                 925            
 Ala Asp Ala Leu Ser Asp Arg Phe Glu Lys Ala Val Tyr Tyr Leu Asp
     930                 935                 940                
 Ala Val Val Ser Phe Ile Glu Cys Gly Asn Ala Leu Glu Lys Asn Ala
 945                 950                 955                 960
 Gln Glu Ser Lys Ser Pro Phe Pro Met Tyr Ser Glu Thr Val Asp Leu
                 965                 970                 975    
 Ile Lys Tyr Thr Met Lys Leu Lys Asn Tyr Leu Ala Pro Asp Ala Thr
             980                 985                 990        
 Ala Ala Asp Lys Arg Leu Thr Val Leu Cys Leu Arg Cys Glu Ser Leu
         995                1000                1005            
 Leu Tyr Leu Arg Leu Phe Lys Leu Lys Lys Glu Asn Ala Leu Lys Tyr
    1010                1015                1020                
 Ser Lys Thr Leu Thr Glu His Leu Lys Asn Ser Tyr Asn Asn Ser Gln
1025                1030                1035                1040
 Ala Pro Ser Pro Gly Leu Gly Ser Lys Ala Val Gly Met Pro Ser Pro
                1045                1050                1055    
 Val Ser Pro Lys Leu Ser Pro Gly Asn Ser Gly Asn Tyr Ser Ser Gly
            1060                1065                1070        
 Ala Ser Ser Ala Ser Ala Ser Gly Ser Ser Val Thr Ile Pro Gln Lys
        1075                1080                1085            
 Ile His Gln Met Ala Ala Ser Tyr Val Gln Val Thr Ser Asn Phe Leu
    1090                1095                1100                
 Tyr Ala Thr Glu Ile Trp Asp Gln Ala Glu Gln Leu Ser Lys Glu Gln
1105                1110                1115                1120
 Lys Glu Phe Phe Ala Glu Leu Asp Lys Val Met Gly Pro Leu Ile Phe
                1125                1130                1135    
 Asn Ala Ser Ile Met Thr Asp Leu Val Arg Tyr Thr Arg Gln Gly Leu
            1140                1145                1150        
 His Trp Leu Arg Gln Asp Ala Lys Leu Ile Ser
        1155                1160            



      <210> 198
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 198
 Met Ala Gly Gly Lys Ala Gly Lys Asp Ser Gly Lys Ala Lys Thr Lys
   1               5                  10                  15    
 Ala Val Ser Arg Ser Gln Arg Ala Gly Leu Gln Phe Pro Val Gly Arg
              20                  25                  30        
 Ile His Arg His Leu Lys Ser Arg Thr Thr Ser His Gly Arg Val Gly
          35                  40                  45            
 Ala Thr Ala Ala Val Tyr Ser Ala Ala Ile Leu Glu Tyr Leu Thr Ala
      50                  55                  60                
 Glu Val Leu Glu Leu Ala Gly Asn Ala Ser Lys Asp Leu Lys Val Lys
  65                  70                  75                  80
 Arg Ile Thr Pro Arg His Leu Gln Leu Ala Ile Arg Gly Asp Glu Glu
                  85                  90                  95    
 Leu Asp Ser Leu Ile Lys Ala Thr Ile Ala Gly Gly Gly Val Ile Pro
             100                 105                 110        
 His Ile His Lys Ser Leu Ile Gly Lys Lys Gly Gln Gln Lys Thr Val
         115                 120                 125            





      <210> 199
      <211> 623
      <212> PRT
      <213> Homo sapiens


      <400> 199
 Met Gly Arg Arg Ile Gln Phe Pro Ile Glu Met Ser Met Pro Trp Ile
   1               5                  10                  15    
 Leu Thr Asp His Ile Leu Glu Thr Lys Glu Ala Ser Met Met Glu Tyr
              20                  25                  30        
 Val Leu Tyr Ser Leu Asp Leu Tyr Asn Asp Ser Ala His Tyr Ala Leu
          35                  40                  45            
 Thr Arg Phe Asn Lys Gln Phe Leu Tyr Asp Glu Ile Glu Ala Glu Val
      50                  55                  60                
 Asn Leu Cys Phe Asp Gln Phe Val Tyr Lys Leu Ala Asp Gln Ile Phe
  65                  70                  75                  80
 Ala Tyr Tyr Lys Val Met Ala Gly Ser Leu Leu Leu Asp Lys Arg Leu
                  85                  90                  95    
 Arg Ser Glu Cys Lys Asn Gln Gly Ala Thr Ile His Leu Pro Pro Ser
             100                 105                 110        
 Asn Arg Tyr Glu Thr Leu Leu Lys Gln Arg His Val Gln Leu Leu Gly
         115                 120                 125            
 Arg Ser Ile Asp Leu Asn Arg Leu Ile Thr Gln Arg Val Ser Ala Ala
     130                 135                 140                
 Met Tyr Lys Ser Leu Glu Leu Ala Ile Gly Arg Phe Glu Ser Glu Asp
 145                 150                 155                 160
 Leu Thr Ser Ile Val Glu Leu Asp Gly Leu Leu Glu Ile Asn Arg Met
                 165                 170                 175    
 Thr His Lys Leu Leu Ser Arg Tyr Leu Thr Leu Asp Gly Phe Asp Ala
             180                 185                 190        
 Met Phe Arg Glu Ala Asn His Asn Val Ser Ala Pro Tyr Gly Arg Ile
         195                 200                 205            
 Thr Leu His Val Phe Trp Glu Leu Asn Tyr Asp Phe Leu Pro Asn Tyr
     210                 215                 220                
 Cys Tyr Asn Gly Ser Thr Asn Arg Phe Val Arg Thr Val Leu Pro Phe
 225                 230                 235                 240
 Ser Gln Glu Phe Gln Arg Asp Lys Gln Pro Asn Ala Gln Pro Gln Tyr
                 245                 250                 255    
 Leu His Gly Ser Lys Ala Leu Asn Leu Ala Tyr Ser Ser Ile Tyr Gly
             260                 265                 270        
 Ser Tyr Arg Asn Phe Val Gly Pro Pro His Phe Gln Val Ile Cys Arg
         275                 280                 285            
 Leu Leu Gly Tyr Gln Gly Ile Ala Val Val Met Glu Glu Leu Leu Lys
     290                 295                 300                
 Val Val Lys Ser Leu Leu Gln Gly Thr Ile Leu Gln Tyr Val Lys Thr
 305                 310                 315                 320
 Leu Met Glu Val Met Pro Lys Ile Cys Arg Leu Pro Arg His Glu Tyr
                 325                 330                 335    
 Gly Ser Pro Gly Ile Leu Glu Phe Phe His His Gln Leu Lys Asp Ile
             340                 345                 350        
 Val Glu Tyr Ala Glu Leu Lys Thr Val Cys Phe Gln Asn Leu Arg Glu
         355                 360                 365            
 Val Gly Asn Ala Ile Leu Phe Cys Leu Leu Ile Glu Gln Ser Leu Ser
     370                 375                 380                
 Leu Glu Glu Val Cys Asp Leu Leu His Ala Ala Pro Phe Gln Asn Ile
 385                 390                 395                 400
 Leu Pro Arg Val His Val Lys Glu Gly Glu Arg Leu Asp Ala Lys Met
                 405                 410                 415    
 Lys Arg Leu Glu Ser Lys Tyr Ala Pro Leu His Leu Val Pro Leu Ile
             420                 425                 430        
 Glu Arg Leu Gly Thr Pro Gln Gln Ile Ala Ile Ala Arg Glu Gly Asp
         435                 440                 445            
 Leu Leu Thr Lys Glu Arg Leu Cys Cys Gly Leu Ser Met Phe Glu Val
     450                 455                 460                
 Ile Leu Thr Arg Ile Arg Ser Phe Leu Asp Asp Pro Ile Trp Arg Gly
 465                 470                 475                 480
 Pro Leu Pro Ser Asn Gly Val Met His Val Asp Glu Cys Val Glu Phe
                 485                 490                 495    
 His Arg Leu Trp Ser Ala Met Gln Phe Val Tyr Cys Ile Pro Val Gly
             500                 505                 510        
 Thr His Glu Phe Thr Val Glu Gln Cys Phe Gly Asp Gly Leu His Trp
         515                 520                 525            
 Ala Gly Cys Met Ile Ile Val Leu Leu Gly Gln Gln Arg Arg Phe Ala
     530                 535                 540                
 Val Leu Asp Phe Cys Tyr His Leu Leu Lys Val Gln Lys His Asp Gly
 545                 550                 555                 560
 Lys Asp Glu Ile Ile Lys Asn Val Pro Leu Lys Lys Met Val Glu Arg
                 565                 570                 575    
 Ile Arg Lys Phe Gln Ile Leu Asn Asp Glu Ile Ile Thr Ile Leu Asp
             580                 585                 590        
 Lys Tyr Leu Lys Ser Gly Asp Gly Glu Gly Thr Pro Val Glu His Val
         595                 600                 605            
 Arg Cys Phe Gln Pro Pro Ile His Gln Ser Leu Ala Ser Ser
     610                 615                 620        



      <210> 200
      <211> 739
      <212> PRT
      <213> Homo sapiens


      <400> 200
 Met Glu Lys Ser Arg Met Asn Leu Pro Lys Gly Pro Asp Thr Leu Cys
   1               5                  10                  15    
 Phe Asp Lys Asp Glu Phe Met Lys Glu Asp Phe Asp Val Asp His Phe
              20                  25                  30        
 Val Ser Asp Cys Arg Lys Arg Val Gln Leu Glu Glu Leu Arg Asp Asp
          35                  40                  45            
 Leu Glu Leu Tyr Tyr Lys Leu Leu Lys Thr Ala Met Val Glu Leu Ile
      50                  55                  60                
 Asn Lys Asp Tyr Ala Asp Phe Val Asn Leu Ser Thr Asn Leu Val Gly
  65                  70                  75                  80
 Met Asp Lys Ala Leu Asn Gln Leu Ser Val Pro Leu Gly Gln Leu Arg
                  85                  90                  95    
 Glu Glu Val Leu Ser Leu Arg Ser Ser Val Ser Glu Gly Ile Arg Ala
             100                 105                 110        
 Val Asp Glu Arg Met Ser Lys Gln Glu Asp Ile Arg Lys Lys Lys Met
         115                 120                 125            
 Cys Val Leu Arg Leu Ile Gln Val Ile Arg Ser Val Glu Lys Ile Glu
     130                 135                 140                
 Lys Ile Leu Asn Ser Gln Ser Ser Lys Glu Thr Ser Ala Leu Glu Ala
 145                 150                 155                 160
 Ser Ser Pro Leu Leu Thr Gly Gln Ile Leu Glu Arg Ile Ala Thr Glu
                 165                 170                 175    
 Phe Asn Gln Leu Gln Phe His Ala Val Gln Ser Lys Gly Met Pro Leu
             180                 185                 190        
 Leu Asp Lys Val Arg Pro Arg Ile Ala Gly Ile Thr Ala Met Leu Gln
         195                 200                 205            
 Gln Ser Leu Glu Gly Leu Leu Leu Glu Gly Leu Gln Thr Ser Asp Val
     210                 215                 220                
 Asp Ile Ile Arg His Cys Leu Arg Thr Tyr Ala Thr Ile Asp Lys Thr
 225                 230                 235                 240
 Arg Asp Ala Glu Ala Leu Val Gly Gln Val Leu Val Lys Pro Tyr Ile
                 245                 250                 255    
 Asp Glu Val Ile Ile Glu Gln Phe Val Glu Ser His Pro Asn Gly Leu
             260                 265                 270        
 Gln Val Met Tyr Asn Lys Leu Leu Glu Phe Val Pro His His Cys Arg
         275                 280                 285            
 Leu Leu Arg Glu Val Thr Gly Gly Ala Ile Ser Ser Glu Lys Gly Asn
     290                 295                 300                
 Thr Val Pro Gly Tyr Asp Phe Leu Val Asn Ser Val Trp Pro Gln Ile
 305                 310                 315                 320
 Val Gln Gly Leu Glu Glu Lys Leu Pro Ser Leu Phe Asn Pro Gly Asn
                 325                 330                 335    
 Pro Asp Ala Phe His Glu Lys Tyr Thr Ile Ser Met Asp Phe Val Arg
             340                 345                 350        
 Arg Leu Glu Arg Gln Cys Gly Ser Gln Ala Ser Val Lys Arg Leu Arg
         355                 360                 365            
 Ala His Pro Ala Tyr His Ser Phe Asn Lys Lys Trp Asn Leu Pro Val
     370                 375                 380                
 Tyr Phe Gln Ile Arg Phe Arg Glu Ile Ala Gly Ser Leu Glu Ala Ala
 385                 390                 395                 400
 Leu Thr Asp Val Leu Glu Asp Ala Pro Ala Glu Ser Pro Tyr Cys Leu
                 405                 410                 415    
 Leu Ala Ser His Arg Thr Trp Ser Ser Leu Arg Arg Cys Trp Ser Asp
             420                 425                 430        
 Glu Met Phe Leu Pro Leu Leu Val His Arg Leu Trp Arg Leu Thr Leu
         435                 440                 445            
 Gln Ile Leu Ala Arg Tyr Ser Val Phe Val Asn Glu Leu Ser Leu Arg
     450                 455                 460                
 Pro Ile Ser Asn Glu Ser Pro Lys Glu Ile Lys Lys Pro Leu Val Thr
 465                 470                 475                 480
 Gly Ser Lys Glu Pro Ser Ile Thr Gln Gly Asn Thr Glu Asp Gln Gly
                 485                 490                 495    
 Ser Gly Pro Ser Glu Thr Lys Pro Val Val Ser Ile Ser Arg Thr Gln
             500                 505                 510        
 Leu Val Tyr Val Val Ala Asp Leu Asp Lys Leu Gln Glu Gln Leu Pro
         515                 520                 525            
 Glu Leu Leu Glu Ile Ile Lys Pro Lys Leu Glu Met Ile Gly Phe Lys
     530                 535                 540                
 Asn Phe Ser Ser Ile Ser Ala Ala Leu Glu Asp Ser Gln Ser Ser Phe
 545                 550                 555                 560
 Ser Ala Cys Val Pro Ser Leu Ser Ser Lys Ile Ile Gln Asp Leu Ser
                 565                 570                 575    
 Asp Ser Cys Phe Gly Phe Leu Lys Ser Ala Leu Glu Val Pro Arg Leu
             580                 585                 590        
 Tyr Arg Arg Thr Asn Lys Glu Val Pro Thr Thr Ala Ser Ser Tyr Val
         595                 600                 605            
 Asp Ser Ala Leu Lys Pro Leu Phe Gln Leu Gln Ser Gly His Lys Asp
     610                 615                 620                
 Lys Leu Lys Gln Ala Ile Ile Gln Gln Trp Leu Glu Gly Thr Leu Ser
 625                 630                 635                 640
 Glu Ser Thr His Lys Tyr Tyr Glu Thr Val Ser Asp Val Leu Asn Ser
                 645                 650                 655    
 Val Lys Lys Met Glu Glu Ser Leu Lys Arg Leu Lys Gln Ala Arg Lys
             660                 665                 670        
 Thr Thr Pro Ala Asn Pro Val Gly Pro Ser Gly Gly Met Ser Asp Asp
         675                 680                 685            
 Asp Lys Ile Arg Leu Gln Leu Ala Leu Asp Val Glu Tyr Leu Gly Glu
     690                 695                 700                
 Gln Ile Gln Lys Leu Gly Leu Gln Ala Ser Asp Ile Lys Ser Phe Ser
 705                 710                 715                 720
 Ala Leu Ala Glu Leu Val Ala Ala Ala Lys Asp Gln Ala Thr Ala Glu
                 725                 730                 735    
 Gln Pro
        



      <210> 201
      <211> 100
      <212> PRT
      <213> Homo sapiens


      <400> 201
 Met Asp Asn Val Gln Pro Lys Ile Lys His Arg Pro Phe Cys Phe Ser
   1               5                  10                  15    
 Val Lys Gly His Val Lys Met Leu Arg Leu Asp Ile Ile Asn Ser Leu
              20                  25                  30        
 Val Thr Thr Val Phe Met Leu Ile Val Ser Val Leu Ala Leu Ile Pro
          35                  40                  45            
 Glu Thr Thr Thr Leu Thr Val Gly Gly Gly Val Phe Ala Leu Val Thr
      50                  55                  60                
 Ala Val Cys Cys Leu Ala Asp Gly Ala Leu Ile Tyr Arg Lys Leu Leu
  65                  70                  75                  80
 Phe Asn Pro Ser Gly Pro Tyr Gln Lys Lys Pro Val His Glu Lys Lys
                  85                  90                  95    
 Glu Val Leu
            



      <210> 202
      <211> 153
      <212> PRT
      <213> Homo sapiens


      <400> 202
 Met Asp Asn Val Gln Pro Lys Ile Lys His Arg Pro Phe Cys Phe Ser
   1               5                  10                  15    
 Val Lys Gly His Val Lys Met Leu Arg Leu Ala Leu Thr Val Thr Ser
              20                  25                  30        
 Met Thr Phe Phe Ile Ile Ala Gln Ala Pro Glu Pro Tyr Ile Val Ile
          35                  40                  45            
 Thr Gly Phe Glu Val Thr Val Ile Leu Phe Phe Ile Leu Leu Tyr Val
      50                  55                  60                
 Leu Arg Leu Asp Arg Leu Met Lys Trp Leu Phe Trp Pro Leu Leu Asp
  65                  70                  75                  80
 Ile Ile Asn Ser Leu Val Thr Thr Val Phe Met Leu Ile Val Ser Val
                  85                  90                  95    
 Leu Ala Leu Ile Pro Glu Thr Thr Thr Leu Thr Val Gly Gly Gly Val
             100                 105                 110        
 Phe Ala Leu Val Thr Ala Val Cys Cys Leu Ala Asp Gly Ala Leu Ile
         115                 120                 125            
 Tyr Arg Lys Leu Leu Phe Asn Pro Ser Gly Pro Tyr Gln Lys Lys Pro
     130                 135                 140                
 Val His Glu Lys Lys Glu Val Leu
 145                 150        



      <210> 203
      <211> 181
      <212> PRT
      <213> Homo sapiens


      <400> 203
 Met Met Lys Phe Lys Pro Asn Gln Thr Arg Thr Tyr Asp Arg Glu Gly
   1               5                  10                  15    
 Phe Lys Lys Arg Ala Ala Cys Leu Cys Phe Arg Ser Glu Gln Glu Asp
              20                  25                  30        
 Glu Val Leu Leu Val Ser Ser Ser Arg Tyr Pro Asp Gln Trp Ile Val
          35                  40                  45            
 Pro Gly Gly Gly Met Glu Pro Glu Glu Glu Pro Gly Gly Ala Ala Val
      50                  55                  60                
 Arg Glu Val Tyr Glu Glu Ala Gly Val Lys Gly Lys Leu Gly Arg Leu
  65                  70                  75                  80
 Leu Gly Ile Phe Glu Asn Gln Asp Arg Lys His Arg Thr Tyr Val Tyr
                  85                  90                  95    
 Val Leu Thr Val Thr Glu Ile Leu Glu Asp Trp Glu Asp Ser Val Asn
             100                 105                 110        
 Ile Gly Arg Lys Arg Glu Trp Phe Lys Val Glu Asp Ala Ile Lys Val
         115                 120                 125            
 Leu Gln Cys His Lys Pro Val His Ala Glu Tyr Leu Glu Lys Leu Lys
     130                 135                 140                
 Leu Gly Cys Ser Pro Ala Asn Gly Asn Ser Thr Val Pro Ser Leu Pro
 145                 150                 155                 160
 Asp Asn Asn Ala Leu Phe Val Thr Ala Ala Gln Thr Ser Gly Leu Pro
                 165                 170                 175    
 Ser Ser Val Arg
             180



      <210> 204
      <211> 171
      <212> PRT
      <213> Homo sapiens


      <400> 204
 Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala
   1               5                  10                  15    
 Arg Glu Cys Pro Thr Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg
              20                  25                  30        
 Gly Arg Gly Phe Gln Phe Val Ser Ser Ser Leu Pro Asp Ile Cys Tyr
          35                  40                  45            
 Arg Cys Gly Glu Ser Gly His Leu Ala Lys Asp Cys Asp Leu Gln Glu
      50                  55                  60                
 Asp Ala Cys Tyr Asn Cys Gly Arg Gly Gly His Ile Ala Lys Asp Cys
  65                  70                  75                  80
 Lys Glu Pro Lys Arg Glu Arg Glu Gln Cys Cys Tyr Asn Cys Gly Lys
                  85                  90                  95    
 Pro Gly His Leu Ala Arg Asp Cys Asp His Ala Asp Glu Gln Lys Cys
             100                 105                 110        
 Tyr Ser Cys Gly Glu Phe Gly His Ile Gln Lys Asp Cys Thr Lys Val
         115                 120                 125            
 Lys Cys Tyr Arg Cys Gly Glu Thr Gly His Val Ala Ile Asn Cys Ser
     130                 135                 140                
 Lys Thr Ser Glu Val Asn Cys Tyr Arg Cys Gly Glu Ser Gly His Leu
 145                 150                 155                 160
 Ala Arg Glu Cys Thr Ile Glu Ala Thr Ala
                 165                 170



      <210> 205
      <211> 178
      <212> PRT
      <213> Homo sapiens


      <400> 205
 Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala
   1               5                  10                  15    
 Arg Glu Cys Pro Thr Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg
              20                  25                  30        
 Gly Arg Gly Gly Phe Thr Ser Asp Arg Gly Phe Gln Phe Val Ser Ser
          35                  40                  45            
 Ser Leu Pro Asp Ile Cys Tyr Arg Cys Gly Glu Ser Gly His Leu Ala
      50                  55                  60                
 Lys Asp Cys Asp Leu Gln Glu Asp Ala Cys Tyr Asn Cys Gly Arg Gly
  65                  70                  75                  80
 Gly His Ile Ala Lys Asp Cys Lys Glu Pro Lys Arg Glu Arg Glu Gln
                  85                  90                  95    
 Cys Cys Tyr Asn Cys Gly Lys Pro Gly His Leu Ala Arg Asp Cys Asp
             100                 105                 110        
 His Ala Asp Glu Gln Lys Cys Tyr Ser Cys Gly Glu Ile Gly His Ile
         115                 120                 125            
 Gln Lys Asp Cys Thr Lys Val Lys Cys Tyr Arg Cys Gly Glu Thr Gly
     130                 135                 140                
 His Val Ala Ile Asn Cys Ser Lys Thr Ser Glu Val Asn Cys Tyr Arg
 145                 150                 155                 160
 Cys Gly Glu Ser Gly His Leu Ala Arg Glu Cys Thr Ile Glu Ala Thr
                 165                 170                 175    
 Ala
    



      <210> 206
      <211> 265
      <212> PRT
      <213> Homo sapiens


      <400> 206
 Met Ala Val Gly Lys Asn Lys Arg Leu Thr Lys Gly Gly Lys Lys Gly
   1               5                  10                  15    
 Ala Lys Lys Lys Val Val Asp Pro Phe Ser Lys Lys Asp Trp Tyr Asp
              20                  25                  30        
 Val Lys Ala Pro Ala Met Phe Asn Ile Arg Asn Ile Gly Lys Thr Leu
          35                  40                  45            
 Val Thr Arg Thr Gln Gly Thr Lys Ile Ala Ser Asp Gly Leu Lys Gly
      50                  55                  60                
 Arg Val Phe Glu Val Ser Leu Ala Asp Leu Gln Asn Asp Glu Val Ala
  65                  70                  75                  80
 Phe Arg Lys Phe Lys Leu Ile Thr Glu Asp Val Gln Gly Lys Asn Cys
                  85                  90                  95    
 Leu Thr Asn Phe His Gly Met Asp Leu Thr Arg Asp Lys Met Cys Ser
             100                 105                 110        
 Met Val Lys Lys Trp Gln Thr Met Ile Glu Ala His Val Asp Val Lys
         115                 120                 125            
 Thr Thr Asp Gly Tyr Leu Leu Arg Leu Phe Cys Val Gly Phe Thr Lys
     130                 135                 140                
 Lys Arg Asn Asn Gln Ile Arg Lys Thr Ser Tyr Ala Gln His Gln Gln
 145                 150                 155                 160
 Val Arg Gln Ile Arg Lys Lys Met Met Glu Ile Met Thr Arg Glu Val
                 165                 170                 175    
 Gln Thr Asn Asp Leu Lys Glu Val Val Asn Lys Leu Ile Pro Asp Ser
             180                 185                 190        
 Ile Gly Lys Asp Ile Glu Lys Ala Cys Gln Ser Ile Tyr Pro Leu His
         195                 200                 205            
 Asp Val Phe Val Arg Lys Val Lys Met Leu Lys Lys Pro Lys Phe Glu
     210                 215                 220                
 Leu Gly Lys Leu Met Glu Leu His Gly Glu Gly Ser Ser Ser Gly Lys
 225                 230                 235                 240
 Ala Thr Gly Asp Glu Thr Gly Ala Lys Val Glu Arg Ala Asp Gly Tyr
                 245                 250                 255    
 Glu Pro Pro Val Gln Glu Ser Val
             260                



      <210> 207
      <211> 294
      <212> PRT
      <213> Homo sapiens


      <400> 207
 Met Phe Arg Trp Glu Arg Ser Ile Pro Leu Arg Gly Ser Ala Ala Ala
   1               5                  10                  15    
 Leu Cys Asn Asn Leu Ser Val Leu Gln Leu Pro Ala Arg Asn Leu Thr
              20                  25                  30        
 Tyr Phe Gly Val Val His Gly Pro Ser Ala Gln Leu Leu Ser Ala Ala
          35                  40                  45            
 Pro Glu Gly Val Pro Leu Ala Gln Arg Gln Leu His Ala Lys Glu Gly
      50                  55                  60                
 Ala Gly Val Ser Pro Pro Leu Ile Thr Gln Val His Trp Cys Val Leu
  65                  70                  75                  80
 Pro Phe Arg Val Leu Leu Val Leu Thr Ser His Arg Gly Ile Gln Met
                  85                  90                  95    
 Tyr Glu Ser Asn Gly Tyr Thr Met Val Tyr Trp His Ala Leu Asp Ser
             100                 105                 110        
 Gly Asp Ala Ser Pro Val Gln Ala Val Phe Ala Arg Gly Ile Ala Ala
         115                 120                 125            
 Ser Gly His Phe Ile Cys Val Gly Thr Trp Ser Gly Arg Val Leu Val
     130                 135                 140                
 Phe Asp Ile Pro Ala Lys Gly Pro Asn Ile Val Leu Ser Glu Glu Leu
 145                 150                 155                 160
 Ala Gly His Gln Met Pro Ile Thr Asp Ile Ala Thr Glu Pro Ala Gln
                 165                 170                 175    
 Gly Gln Leu Trp Gln Gly Ile Ile Ala Ala Gly Tyr Gly Asn Gly Gln
             180                 185                 190        
 Val His Leu Tyr Glu Ala Thr Thr Gly Asn Leu His Val Gln Ile Asn
         195                 200                 205            
 Ala His Ala Arg Ala Ile Cys Ala Leu Asp Leu Ala Phe Glu Val Gly
     210                 215                 220                
 Lys Leu Leu Ser Ala Gly Glu Asp Thr Phe Val His Ile Trp Lys Leu
 225                 230                 235                 240
 Ser Arg Asn Pro Glu Ser Gly Tyr Ile Glu Val Glu His Cys His Gly
                 245                 250                 255    
 Glu Cys Val Ala Asp Thr Gln Leu Cys Gly Ala Arg Phe Cys Asp Ser
             260                 265                 270        
 Ser Gly Asn Ser Phe Ala Val Thr Gly Tyr Asp Leu Ala Glu Ile Arg
         275                 280                 285            
 Arg Phe Ser Ser Val
     290            



      <210> 208
      <211> 317
      <212> PRT
      <213> Homo sapiens


      <400> 208
 Met Phe Arg Trp Glu Arg Ser Ile Pro Leu Arg Gly Ser Ala Ala Ala
   1               5                  10                  15    
 Leu Cys Asn Asn Leu Ser Val Leu Gln Leu Pro Ala Arg Asn Leu Thr
              20                  25                  30        
 Tyr Phe Gly Val Val His Gly Pro Ser Ala Gln Leu Leu Ser Ala Ala
          35                  40                  45            
 Pro Glu Gly Val Pro Leu Ala Gln Arg Gln Leu His Ala Lys Glu Gly
      50                  55                  60                
 Ala Gly Val Ser Pro Pro Leu Ile Thr Gln Val His Trp Cys Val Leu
  65                  70                  75                  80
 Pro Phe Arg Val Leu Leu Val Leu Thr Ser His Arg Gly Ile Gln Met
                  85                  90                  95    
 Tyr Glu Ser Asn Gly Tyr Thr Met Val Tyr Trp His Ala Leu Asp Ser
             100                 105                 110        
 Gly Asp Ala Ser Pro Gly Thr Trp Ser Gly Arg Val Leu Val Phe Asp
         115                 120                 125            
 Ile Pro Ala Lys Gly Pro Asn Ile Val Leu Ser Glu Glu Leu Ala Gly
     130                 135                 140                
 His Gln Met Pro Ile Thr Asp Ile Ala Thr Glu Pro Ala Gln Gly Gln
 145                 150                 155                 160
 Asp Cys Val Ala Asp Met Val Thr Ala Asp Asp Ser Gly Leu Leu Cys
                 165                 170                 175    
 Val Trp Arg Ser Gly Pro Glu Phe Thr Leu Leu Thr Arg Ile Pro Gly
             180                 185                 190        
 Phe Gly Val Pro Cys Pro Ser Val Gln Leu Trp Gln Gly Ile Ile Ala
         195                 200                 205            
 Ala Gly Tyr Gly Asn Gly Gln Val His Leu Tyr Glu Ala Thr Thr Gly
     210                 215                 220                
 Asn Leu His Val Gln Ile Asn Ala His Ala Arg Ala Ile Cys Ala Leu
 225                 230                 235                 240
 Asp Leu Ala Phe Glu Val Gly Lys Leu Leu Ser Ala Gly Glu Asp Thr
                 245                 250                 255    
 Phe Val His Ile Trp Lys Leu Ser Arg Asn Pro Glu Ser Gly Tyr Ile
             260                 265                 270        
 Glu Val Glu His Cys His Gly Glu Cys Val Ala Asp Thr Gln Leu Cys
         275                 280                 285            
 Gly Ala Arg Phe Cys Asp Ser Ser Gly Asn Ser Phe Ala Val Thr Gly
     290                 295                 300                
 Tyr Asp Leu Ala Glu Ile Arg Arg Phe Ser Ser Val
 305                 310                 315    



      <210> 209
      <211> 314
      <212> PRT
      <213> Homo sapiens


      <400> 209
 Met Thr Pro Pro Cys Ala Gly Trp Phe Leu Ser Leu Phe Pro Trp Ser
   1               5                  10                  15    
 Arg Leu Leu Met Glu Ala Gly Pro Val Arg Asp Leu Arg Leu Lys Lys
              20                  25                  30        
 Lys Lys Ala Val Arg Pro Ile Thr Glu Arg Ser Leu Leu Gln Gly Asp
          35                  40                  45            
 Glu Ile Trp Asn Ala Leu Thr Asp Asn Tyr Gly Asn Val Met Pro Val
      50                  55                  60                
 Asp Trp Lys Ser Ser His Thr Arg Thr Leu His Leu Leu Thr Leu Asn
  65                  70                  75                  80
 Leu Ser Glu Lys Gly Val Ser Asp Ser Leu Leu Phe Asp Thr Ser Asp
                  85                  90                  95    
 Asp Glu Glu Leu Arg Glu Gln Leu Asp Met His Ser Ile Ile Val Ser
             100                 105                 110        
 Cys Val Asn Asp Glu Pro Leu Phe Thr Ala Asp Gln Val Ile Glu Glu
         115                 120                 125            
 Ile Glu Glu Met Met Gln Glu Ser Pro Asp Pro Glu Asp Asp Glu Thr
     130                 135                 140                
 Pro Thr Gln Ser Asp Arg Leu Ser Met Leu Ser Gln Glu Ile Gln Thr
 145                 150                 155                 160
 Leu Lys Arg Ser Ser Thr Gly Ser Tyr Glu Glu Arg Val Lys Arg Leu
                 165                 170                 175    
 Ser Val Ser Glu Leu Asn Glu Ile Leu Glu Glu Ile Glu Thr Ala Ile
             180                 185                 190        
 Lys Glu Tyr Ser Glu Glu Leu Val Gln Gln Leu Ala Leu Arg Asp Glu
         195                 200                 205            
 Leu Glu Phe Glu Lys Glu Val Lys Asn Ser Phe Ile Ser Val Leu Ile
     210                 215                 220                
 Glu Val Gln Asn Lys Gln Lys Glu His Lys Glu Thr Ala Lys Lys Lys
 225                 230                 235                 240
 Lys Lys Leu Lys Asn Gly Ser Ser Gln Asn Gly Lys Asn Glu Arg Ser
                 245                 250                 255    
 His Met Pro Gly Thr Tyr Leu Thr Thr Val Ile Pro Tyr Glu Lys Lys
             260                 265                 270        
 Asn Gly Pro Pro Ser Val Glu Asp Leu Gln Ile Leu Thr Lys Ile Leu
         275                 280                 285            
 Arg Ala Met Lys Glu Asp Ser Glu Lys Val Pro Ser Leu Leu Thr Asp
     290                 295                 300                
 Tyr Ile Leu Lys Val Leu Cys Pro Thr
 305                 310            



      <210> 210
      <211> 341
      <212> PRT
      <213> Homo sapiens


      <400> 210
 Met Thr Pro Pro Cys Ala Gly Trp Phe Leu Ser Leu Phe Pro Trp Ser
   1               5                  10                  15    
 Arg Leu Leu Met Glu Ala Gly Pro Val Arg Asp Leu Arg Leu Lys Lys
              20                  25                  30        
 Lys Lys Ala Val Arg Pro Ile Thr Glu Arg Ser Leu Leu Gln Gly Asp
          35                  40                  45            
 Glu Ile Trp Asn Ala Leu Thr Asp Asn Tyr Gly Asn Val Met Pro Val
      50                  55                  60                
 Asp Trp Lys Ser Ser His Thr Arg Thr Leu His Leu Leu Thr Leu Asn
  65                  70                  75                  80
 Leu Ser Glu Lys Gly Val Ser Asp Ser Leu Leu Phe Asp Thr Ser Asp
                  85                  90                  95    
 Asp Glu Glu Leu Arg Glu Gln Leu Asp Met His Ser Ile Ile Val Ser
             100                 105                 110        
 Cys Val Asn Asp Glu Pro Leu Phe Thr Ala Asp Gln Val Ile Glu Glu
         115                 120                 125            
 Ile Glu Glu Met Met Gln Glu Ser Pro Asp Pro Glu Asp Asp Glu Thr
     130                 135                 140                
 Pro Thr Gln Ser Asp Arg Leu Ser Met Leu Ser Gln Glu Ile Gln Thr
 145                 150                 155                 160
 Leu Lys Arg Ser Ser Thr Gly Ser Tyr Glu Glu Arg Val Lys Arg Leu
                 165                 170                 175    
 Ser Val Ser Glu Leu Asn Glu Ile Leu Glu Glu Ile Glu Thr Ala Ile
             180                 185                 190        
 Lys Glu Tyr Ser Glu Glu Leu Val Gln Gln Leu Ala Leu Arg Asp Glu
         195                 200                 205            
 Leu Glu Phe Glu Lys Glu Val Lys Asn Ser Phe Ile Ser Val Leu Ile
     210                 215                 220                
 Glu Val Gln Asn Lys Gln Lys Glu His Lys Glu Thr Ala Lys Lys Lys
 225                 230                 235                 240
 Lys Lys Leu Lys Asn Gly Ser Ser Gln Asn Gly Lys Asn Glu Arg Ser
                 245                 250                 255    
 His Met Pro Gly Thr Arg Phe Ser Met Glu Gly Ile Ser Asn Val Ile
             260                 265                 270        
 Gln Asn Gly Leu Arg His Thr Phe Gly Asn Ser Gly Gly Glu Lys Gln
         275                 280                 285            
 Tyr Leu Thr Thr Val Ile Pro Tyr Glu Lys Lys Asn Gly Pro Pro Ser
     290                 295                 300                
 Val Glu Asp Leu Gln Ile Leu Thr Lys Ile Leu Arg Ala Met Lys Glu
 305                 310                 315                 320
 Asp Ser Glu Lys Val Pro Ser Leu Leu Thr Asp Tyr Ile Leu Lys Val
                 325                 330                 335    
 Leu Cys Pro Thr
             340



      <210> 211
      <211> 528
      <212> PRT
      <213> Homo sapiens


      <400> 211
 Met Leu Leu Pro Leu Leu Leu Leu Leu Pro Met Cys Trp Ala Val Glu
   1               5                  10                  15    
 Val Lys Arg Pro Arg Gly Val Ser Leu Thr Asn His His Phe Tyr Asp
              20                  25                  30        
 Glu Ser Lys Pro Phe Thr Cys Leu Asp Gly Ser Ala Thr Ile Pro Phe
          35                  40                  45            
 Asp Gln Val Asn Asp Asp Tyr Cys Asp Cys Lys Asp Gly Ser Asp Glu
      50                  55                  60                
 Pro Gly Thr Ala Ala Cys Pro Asn Gly Ser Phe His Cys Thr Asn Thr
  65                  70                  75                  80
 Gly Tyr Lys Pro Leu Tyr Ile Pro Ser Asn Arg Val Asn Asp Gly Val
                  85                  90                  95    
 Cys Asp Cys Cys Asp Gly Thr Asp Glu Tyr Asn Ser Gly Val Ile Cys
             100                 105                 110        
 Glu Asn Thr Cys Lys Glu Lys Gly Arg Lys Glu Arg Glu Ser Leu Gln
         115                 120                 125            
 Gln Met Ala Glu Val Thr Arg Glu Gly Phe Arg Leu Lys Lys Ile Leu
     130                 135                 140                
 Ile Glu Asp Trp Lys Lys Ala Arg Glu Glu Lys Gln Lys Lys Leu Ile
 145                 150                 155                 160
 Glu Leu Gln Ala Gly Lys Lys Ser Leu Glu Asp Gln Val Glu Met Leu
                 165                 170                 175    
 Arg Thr Val Lys Glu Glu Ala Glu Lys Pro Glu Arg Glu Ala Lys Glu
             180                 185                 190        
 Gln His Gln Lys Leu Trp Glu Glu Gln Leu Ala Ala Ala Lys Ala Gln
         195                 200                 205            
 Gln Glu Gln Glu Leu Ala Ala Asp Ala Phe Lys Glu Leu Asp Asp Asp
     210                 215                 220                
 Met Asp Gly Thr Val Ser Val Thr Glu Leu Gln Thr His Pro Glu Leu
 225                 230                 235                 240
 Asp Thr Asp Gly Asp Gly Ala Leu Ser Glu Ala Glu Ala Gln Ala Leu
                 245                 250                 255    
 Leu Ser Gly Asp Thr Gln Thr Asp Ala Thr Ser Phe Tyr Asp Arg Val
             260                 265                 270        
 Trp Ala Ala Ile Arg Asp Lys Tyr Arg Ser Glu Ala Leu Pro Thr Asp
         275                 280                 285            
 Leu Pro Ala Pro Ser Ala Pro Asp Leu Thr Glu Pro Lys Glu Glu Gln
     290                 295                 300                
 Pro Pro Val Pro Ser Ser Pro Thr Glu Glu Glu Glu Glu Glu Glu Glu
 305                 310                 315                 320
 Glu Glu Glu Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Ser Glu Glu
                 325                 330                 335    
 Ala Pro Pro Pro Leu Ser Pro Pro Gln Pro Ala Ser Pro Ala Glu Glu
             340                 345                 350        
 Asp Lys Met Pro Pro Tyr Asp Glu Gln Thr Gln Ala Phe Ile Asp Ala
         355                 360                 365            
 Ala Gln Glu Ala Arg Asn Lys Phe Glu Glu Ala Glu Arg Ser Leu Lys
     370                 375                 380                
 Asp Met Glu Glu Ser Ile Arg Asn Leu Glu Gln Glu Ile Ser Phe Asp
 385                 390                 395                 400
 Phe Gly Pro Asn Gly Glu Phe Ala Tyr Leu Tyr Ser Gln Cys Tyr Glu
                 405                 410                 415    
 Leu Thr Thr Asn Glu Tyr Val Tyr Arg Leu Cys Pro Phe Lys Leu Val
             420                 425                 430        
 Ser Gln Lys Pro Lys Leu Gly Gly Ser Pro Thr Ser Leu Gly Thr Trp
         435                 440                 445            
 Gly Ser Trp Ile Gly Pro Asp His Asp Lys Phe Ser Ala Met Lys Tyr
     450                 455                 460                
 Glu Gln Gly Thr Gly Cys Trp Gln Gly Pro Asn Arg Ser Thr Thr Val
 465                 470                 475                 480
 Arg Leu Leu Cys Gly Lys Glu Thr Met Val Thr Ser Thr Thr Glu Pro
                 485                 490                 495    
 Ser Arg Cys Glu Tyr Leu Met Glu Leu Met Thr Pro Ala Ala Cys Pro
             500                 505                 510        
 Glu Pro Pro Pro Glu Ala Pro Thr Glu Asp Asp His Asp Glu Leu
         515                 520                 525        



      <210> 212
      <211> 525
      <212> PRT
      <213> Homo sapiens


      <400> 212
 Met Leu Leu Pro Leu Leu Leu Leu Leu Pro Met Cys Trp Ala Val Glu
   1               5                  10                  15    
 Val Lys Arg Pro Arg Gly Val Ser Leu Thr Asn His His Phe Tyr Asp
              20                  25                  30        
 Glu Ser Lys Pro Phe Thr Cys Leu Asp Gly Ser Ala Thr Ile Pro Phe
          35                  40                  45            
 Asp Gln Val Asn Asp Asp Tyr Cys Asp Cys Lys Asp Gly Ser Asp Glu
      50                  55                  60                
 Pro Gly Thr Ala Ala Cys Pro Asn Gly Ser Phe His Cys Thr Asn Thr
  65                  70                  75                  80
 Gly Tyr Lys Pro Leu Tyr Ile Pro Ser Asn Arg Val Asn Asp Gly Val
                  85                  90                  95    
 Cys Asp Cys Cys Asp Gly Thr Asp Glu Tyr Asn Ser Gly Val Ile Cys
             100                 105                 110        
 Glu Asn Thr Cys Lys Glu Lys Gly Arg Lys Glu Arg Glu Ser Leu Gln
         115                 120                 125            
 Gln Met Ala Glu Val Thr Arg Glu Gly Phe Arg Leu Lys Lys Ile Leu
     130                 135                 140                
 Ile Glu Asp Trp Lys Lys Ala Arg Glu Glu Lys Gln Lys Lys Leu Ile
 145                 150                 155                 160
 Glu Leu Gln Ala Gly Lys Lys Ser Leu Glu Asp Gln Val Glu Met Leu
                 165                 170                 175    
 Arg Thr Val Lys Glu Glu Ala Glu Lys Pro Glu Arg Glu Ala Lys Glu
             180                 185                 190        
 Gln His Gln Lys Leu Trp Glu Glu Gln Leu Ala Ala Ala Lys Ala Gln
         195                 200                 205            
 Gln Glu Gln Glu Leu Ala Ala Asp Ala Phe Lys Glu Leu Asp Asp Asp
     210                 215                 220                
 Met Asp Gly Thr Val Ser Val Thr Glu Leu Gln Thr His Pro Glu Leu
 225                 230                 235                 240
 Asp Thr Asp Gly Asp Gly Ala Leu Ser Glu Ala Glu Ala Gln Ala Leu
                 245                 250                 255    
 Leu Ser Gly Asp Thr Gln Thr Asp Ala Thr Ser Phe Tyr Asp Arg Val
             260                 265                 270        
 Trp Ala Ala Ile Arg Asp Lys Tyr Arg Ser Glu Ala Leu Pro Thr Asp
         275                 280                 285            
 Leu Pro Ala Pro Ser Ala Pro Asp Leu Thr Glu Pro Lys Glu Glu Gln
     290                 295                 300                
 Pro Pro Val Pro Ser Ser Pro Thr Glu Glu Glu Glu Glu Glu Glu Glu
 305                 310                 315                 320
 Glu Glu Glu Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Ser Glu Val
                 325                 330                 335    
 Gln Gly Glu Gln Pro Lys Pro Ala Ser Pro Ala Glu Glu Asp Lys Met
             340                 345                 350        
 Pro Pro Tyr Asp Glu Gln Thr Gln Ala Phe Ile Asp Ala Ala Gln Glu
         355                 360                 365            
 Ala Arg Asn Lys Phe Glu Glu Ala Glu Arg Ser Leu Lys Asp Met Glu
     370                 375                 380                
 Glu Ser Ile Arg Asn Leu Glu Gln Glu Ile Ser Phe Asp Phe Gly Pro
 385                 390                 395                 400
 Asn Gly Glu Phe Ala Tyr Leu Tyr Ser Gln Cys Tyr Glu Leu Thr Thr
                 405                 410                 415    
 Asn Glu Tyr Val Tyr Arg Leu Cys Pro Phe Lys Leu Val Ser Gln Lys
             420                 425                 430        
 Pro Lys Leu Gly Gly Ser Pro Thr Ser Leu Gly Thr Trp Gly Ser Trp
         435                 440                 445            
 Ile Gly Pro Asp His Asp Lys Phe Ser Ala Met Lys Tyr Glu Gln Gly
     450                 455                 460                
 Thr Gly Cys Trp Gln Gly Pro Asn Arg Ser Thr Thr Val Arg Leu Leu
 465                 470                 475                 480
 Cys Gly Lys Glu Thr Met Val Thr Ser Thr Thr Glu Pro Ser Arg Cys
                 485                 490                 495    
 Glu Tyr Leu Met Glu Leu Met Thr Pro Ala Ala Cys Pro Glu Pro Pro
             500                 505                 510        
 Pro Glu Ala Pro Thr Glu Asp Asp His Asp Glu Leu
         515                 520                



      <210> 213
      <211> 535
      <212> PRT
      <213> Homo sapiens


      <400> 213
 Met Leu Leu Pro Leu Leu Leu Leu Leu Pro Met Cys Trp Ala Val Glu
   1               5                  10                  15    
 Val Lys Arg Pro Arg Gly Val Ser Leu Thr Asn His His Phe Tyr Asp
              20                  25                  30        
 Glu Ser Lys Pro Phe Thr Cys Leu Asp Gly Ser Ala Thr Ile Pro Phe
          35                  40                  45            
 Asp Gln Val Asn Asp Asp Tyr Cys Asp Cys Lys Asp Gly Ser Asp Glu
      50                  55                  60                
 Pro Gly Thr Ala Ala Cys Pro Asn Gly Ser Phe His Cys Thr Asn Thr
  65                  70                  75                  80
 Gly Tyr Lys Pro Leu Tyr Ile Pro Ser Asn Arg Val Asn Asp Gly Val
                  85                  90                  95    
 Cys Asp Cys Cys Asp Gly Thr Asp Glu Tyr Asn Ser Gly Val Ile Cys
             100                 105                 110        
 Glu Asn Thr Cys Lys Glu Lys Gly Arg Lys Glu Arg Glu Ser Leu Gln
         115                 120                 125            
 Gln Met Ala Glu Val Thr Arg Glu Gly Phe Arg Leu Lys Lys Ile Leu
     130                 135                 140                
 Ile Glu Asp Trp Lys Lys Ala Arg Glu Glu Lys Gln Lys Lys Leu Ile
 145                 150                 155                 160
 Glu Leu Gln Ala Gly Lys Lys Ser Leu Glu Asp Gln Val Glu Met Leu
                 165                 170                 175    
 Arg Thr Val Lys Glu Glu Ala Glu Lys Pro Glu Arg Glu Ala Lys Glu
             180                 185                 190        
 Gln His Gln Lys Leu Trp Glu Glu Gln Leu Ala Ala Ala Lys Ala Gln
         195                 200                 205            
 Gln Glu Gln Glu Leu Ala Ala Asp Ala Phe Lys Glu Leu Asp Asp Asp
     210                 215                 220                
 Met Asp Gly Thr Val Ser Val Thr Glu Leu Gln Thr His Pro Glu Leu
 225                 230                 235                 240
 Asp Thr Asp Gly Asp Gly Ala Leu Ser Glu Ala Glu Ala Gln Ala Leu
                 245                 250                 255    
 Leu Ser Gly Asp Thr Gln Thr Asp Ala Thr Ser Phe Tyr Asp Arg Val
             260                 265                 270        
 Trp Ala Ala Ile Arg Asp Lys Tyr Arg Ser Glu Ala Leu Pro Thr Asp
         275                 280                 285            
 Leu Pro Ala Pro Ser Ala Pro Asp Leu Thr Glu Pro Lys Glu Glu Gln
     290                 295                 300                
 Pro Pro Val Pro Ser Ser Pro Thr Glu Glu Glu Glu Glu Glu Glu Glu
 305                 310                 315                 320
 Glu Glu Glu Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Ser Glu Val
                 325                 330                 335    
 Gln Gly Glu Gln Pro Lys Glu Ala Pro Pro Pro Leu Ser Pro Pro Gln
             340                 345                 350        
 Pro Ala Ser Pro Ala Glu Glu Asp Lys Met Pro Pro Tyr Asp Glu Gln
         355                 360                 365            
 Thr Gln Ala Phe Ile Asp Ala Ala Gln Glu Ala Arg Asn Lys Phe Glu
     370                 375                 380                
 Glu Ala Glu Arg Ser Leu Lys Asp Met Glu Glu Ser Ile Arg Asn Leu
 385                 390                 395                 400
 Glu Gln Glu Ile Ser Phe Asp Phe Gly Pro Asn Gly Glu Phe Ala Tyr
                 405                 410                 415    
 Leu Tyr Ser Gln Cys Tyr Glu Leu Thr Thr Asn Glu Tyr Val Tyr Arg
             420                 425                 430        
 Leu Cys Pro Phe Lys Leu Val Ser Gln Lys Pro Lys Leu Gly Gly Ser
         435                 440                 445            
 Pro Thr Ser Leu Gly Thr Trp Gly Ser Trp Ile Gly Pro Asp His Asp
     450                 455                 460                
 Lys Phe Ser Ala Met Lys Tyr Glu Gln Gly Thr Gly Cys Trp Gln Gly
 465                 470                 475                 480
 Pro Asn Arg Ser Thr Thr Val Arg Leu Leu Cys Gly Lys Glu Thr Met
                 485                 490                 495    
 Val Thr Ser Thr Thr Glu Pro Ser Arg Cys Glu Tyr Leu Met Glu Leu
             500                 505                 510        
 Met Thr Pro Ala Ala Cys Pro Glu Pro Pro Pro Glu Ala Pro Thr Glu
         515                 520                 525            
 Asp Asp His Asp Glu Leu
     530                



      <210> 214
      <211> 387
      <212> PRT
      <213> Homo sapiens


      <400> 214
 Met Pro Glu Glu Thr Gln Thr Gln Asp Gln Pro Met Glu Glu Glu Glu
   1               5                  10                  15    
 Val Glu Thr Phe Ala Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu
              20                  25                  30        
 Ile Ile Asn Thr Phe Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu
          35                  40                  45            
 Ile Ser Asn Ser Ser Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu
      50                  55                  60                
 Thr Asp Pro Ser Lys Leu Asp Ser Gly Lys Glu Leu His Ile Asn Leu
  65                  70                  75                  80
 Ile Pro Asn Lys Gln Asp Arg Thr Leu Thr Ile Val Asp Thr Gly Ile
                  85                  90                  95    
 Gly Met Thr Lys Ala Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys
             100                 105                 110        
 Ser Gly Thr Lys Ala Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile
         115                 120                 125            
 Ser Met Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val
     130                 135                 140                
 Ala Glu Lys Val Thr Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr
 145                 150                 155                 160
 Ala Trp Glu Ser Ser Ala Gly Gly Ser Phe Thr Val Arg Thr Asp Thr
                 165                 170                 175    
 Gly Glu Pro Met Gly Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu
             180                 185                 190        
 Asp Gln Thr Glu Tyr Leu Glu Glu Arg Arg Ile Lys Glu Ile Val Lys
         195                 200                 205            
 Lys His Ser Gln Phe Ile Gly Tyr Pro Ile Thr Leu Phe Val Glu Lys
     210                 215                 220                
 Glu Arg Asp Lys Glu Val Ser Asp Asp Glu Ala Glu Glu Lys Glu Asp
 225                 230                 235                 240
 Lys Glu Glu Glu Lys Lys Lys Glu Glu Lys Glu Ser Glu Asp Lys Pro
                 245                 250                 255    
 Glu Ile Glu Asp Val Gly Ser Asp Glu Glu Glu Glu Lys Lys Asp Gly
             260                 265                 270        
 Asp Lys Lys Lys Lys Lys Lys Ile Lys Glu Lys Tyr Ile Asp Gln Glu
         275                 280                 285            
 Glu Leu Asn Lys Thr Lys Pro Ile Trp Thr Arg Asn Pro Asp Asp Ile
     290                 295                 300                
 Thr Asn Glu Glu Tyr Gly Glu Phe Tyr Lys Ser Leu Thr Asn Asp Trp
 305                 310                 315                 320
 Glu Asp His Leu Ala Val Lys His Phe Ser Val Glu Gly Gln Leu Glu
                 325                 330                 335    
 Phe Arg Ala Leu Leu Phe Val Pro Arg Arg Ala Pro Phe Asp Leu Phe
             340                 345                 350        
 Glu Asn Arg Lys Lys Lys Asn Asn Ile Lys Leu Tyr Val Arg Arg Val
         355                 360                 365            
 Phe Ile Met Asp Asn Cys Glu Glu Leu Ile Pro Glu Tyr Leu Ser Lys
     370                 375                 380                
 Tyr Arg
 385    



      <210> 215
      <211> 276
      <212> PRT
      <213> Homo sapiens


      <400> 215
 Met Lys Pro Ile Leu Leu Gln Gly His Glu Arg Ser Ile Thr Gln Ile
   1               5                  10                  15    
 Lys Tyr Asn Arg Glu Gly Asp Leu Leu Phe Thr Val Ala Lys Asp Pro
              20                  25                  30        
 Ile Val Asn Val Trp Tyr Ser Val Asn Gly Glu Arg Leu Gly Thr Tyr
          35                  40                  45            
 Met Gly His Thr Gly Ala Val Trp Cys Val Asp Ala Asp Trp Asp Thr
      50                  55                  60                
 Lys His Val Leu Thr Gly Ser Ala Asp Asn Ser Cys Arg Leu Trp Asp
  65                  70                  75                  80
 Cys Glu Thr Asp Asn Asn Glu Pro Tyr Met Lys Ile Pro Cys Asn Asp
                  85                  90                  95    
 Ser Lys Ile Thr Ser Ala Val Trp Gly Pro Leu Gly Glu Cys Ile Ile
             100                 105                 110        
 Ala Gly His Glu Ser Gly Glu Leu Asn Gln Tyr Ser Ala Lys Ser Gly
         115                 120                 125            
 Glu Val Leu Val Asn Val Lys Glu His Ser Arg Gln Ile Asn Asp Ile
     130                 135                 140                
 Gln Leu Ser Arg Asp Met Thr Met Phe Val Thr Ala Ser Lys Asp Asn
 145                 150                 155                 160
 Thr Ala Lys Leu Phe Asp Ser Thr Thr Leu Glu His Gln Lys Thr Phe
                 165                 170                 175    
 Arg Thr Glu Arg Pro Val Asn Ser Ala Ala Leu Ser Pro Asn Tyr Asp
             180                 185                 190        
 His Val Val Leu Gly Gly Gly Gln Glu Ala Met Asp Val Thr Thr Thr
         195                 200                 205            
 Ser Thr Arg Ile Gly Lys Phe Glu Ala Arg Phe Phe His Leu Ala Phe
     210                 215                 220                
 Glu Glu Glu Phe Gly Arg Val Lys Gly His Phe Gly Pro Ile Asn Ser
 225                 230                 235                 240
 Val Ala Phe His Pro Asp Gly Lys Ser Tyr Ser Ser Gly Gly Glu Asp
                 245                 250                 255    
 Gly Tyr Val Arg Ile His Tyr Phe Asp Pro Gln Tyr Phe Glu Phe Glu
             260                 265                 270        
 Phe Glu Ala
         275



      <210> 216
      <211> 361
      <212> PRT
      <213> Homo sapiens


      <400> 216
 Met Lys Pro Ile Leu Leu Gln Gly His Glu Arg Ser Ile Thr Gln Ile
   1               5                  10                  15    
 Lys Tyr Asn Arg Glu Gly Asp Leu Leu Phe Thr Val Ala Lys Asp Pro
              20                  25                  30        
 Ile Val Asn Val Trp Tyr Ser Val Asn Gly Glu Arg Leu Gly Thr Tyr
          35                  40                  45            
 Met Gly His Thr Gly Ala Val Trp Cys Val Asp Ala Asp Trp Asp Thr
      50                  55                  60                
 Lys His Val Leu Thr Gly Ser Ala Asp Asn Ser Cys Arg Leu Trp Asp
  65                  70                  75                  80
 Cys Glu Thr Gly Lys Gln Leu Ala Leu Leu Lys Thr Asn Ser Ala Val
                  85                  90                  95    
 Arg Thr Cys Gly Phe Asp Phe Gly Gly Asn Ile Ile Met Phe Ser Thr
             100                 105                 110        
 Asp Lys Gln Met Gly Tyr Gln Cys Phe Val Ser Phe Phe Asp Leu Arg
         115                 120                 125            
 Asp Pro Ser Gln Ile Asp Asn Asn Glu Pro Tyr Met Lys Ile Pro Cys
     130                 135                 140                
 Asn Asp Ser Lys Ile Thr Ser Ala Val Trp Gly Pro Leu Gly Glu Cys
 145                 150                 155                 160
 Ile Ile Ala Gly His Glu Ser Gly Glu Leu Asn Gln Tyr Ser Ala Lys
                 165                 170                 175    
 Ser Gly Glu Val Leu Val Asn Val Lys Glu His Ser Arg Gln Ile Asn
             180                 185                 190        
 Asp Ile Gln Leu Ser Arg Asp Met Thr Met Phe Val Thr Ala Ser Lys
         195                 200                 205            
 Asp Asn Thr Ala Lys Leu Phe Asp Ser Thr Thr Leu Glu His Gln Lys
     210                 215                 220                
 Thr Phe Arg Thr Glu Arg Pro Val Asn Ser Ala Ala Leu Ser Pro Asn
 225                 230                 235                 240
 Tyr Asp His Val Val Leu Gly Gly Gly Gln Glu Ala Met Asp Val Thr
                 245                 250                 255    
 Thr Thr Ser Thr Arg Ile Gly Lys Phe Glu Ala Arg Phe Phe His Leu
             260                 265                 270        
 Ala Leu Lys Lys Ser Leu Glu Glu Ser Arg Val Thr Leu Asp Leu Ser
         275                 280                 285            
 Thr Val Leu Pro Ser Ile Leu Met Ala Arg Ala Thr Ala Ala Ala Ala
     290                 295                 300                
 Lys Met Val Thr Ser Val Ser Ile Thr Ser Thr His Ser Thr Ser Asn
 305                 310                 315                 320
 Leu Ser Leu Arg Leu Lys Lys Leu Asp Leu Leu Pro Gly Val Val Ala
                 325                 330                 335    
 His Ala Cys Asn Pro Thr Thr Phe Phe Phe Lys Ala Gly Gly Ser Pro
             340                 345                 350        
 Glu Val Arg Ser Leu Arg Pro Ala
         355                 360



      <210> 217
      <211> 449
      <212> PRT
      <213> Homo sapiens


      <400> 217
 Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu
   1               5                  10                  15    
 Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln
              20                  25                  30        
 Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn
          35                  40                  45            
 Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn
      50                  55                  60                
 Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys
  65                  70                  75                  80
 Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys
                  85                  90                  95    
 Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu
             100                 105                 110        
 Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val
         115                 120                 125            
 Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu
     130                 135                 140                
 Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp
 145                 150                 155                 160
 Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met
                 165                 170                 175    
 Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln
             180                 185                 190        
 Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro
         195                 200                 205            
 Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg
     210                 215                 220                
 Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe
 225                 230                 235                 240
 His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln
                 245                 250                 255    
 Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr
             260                 265                 270        
 Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile
         275                 280                 285            
 Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys
     290                 295                 300                
 Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln
 305                 310                 315                 320
 Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg
                 325                 330                 335    
 Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met
             340                 345                 350        
 Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp
         355                 360                 365            
 Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu
     370                 375                 380                
 Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser
 385                 390                 395                 400
 Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr
                 405                 410                 415    
 Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu
             420                 425                 430        
 Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu
         435                 440                 445            
 Glu
    



      <210> 218
      <211> 617
      <212> PRT
      <213> Homo sapiens


      <400> 218
 Met Ser Gly Val Arg Gly Leu Ser Arg Leu Leu Ser Ala Arg Arg Leu
   1               5                  10                  15    
 Ala Leu Ala Lys Ala Trp Pro Thr Val Leu Gln Thr Gly Thr Arg Gly
              20                  25                  30        
 Phe His Phe Thr Val Val Gly Asn Lys Arg Ala Ser Ala Lys Val Ser
          35                  40                  45            
 Asp Ser Ile Ser Ala Gln Tyr Pro Val Val Asp His Glu Phe Asp Ala
      50                  55                  60                
 Val Val Val Gly Ala Gly Gly Ala Gly Leu Arg Ala Ala Phe Gly Leu
  65                  70                  75                  80
 Ser Glu Ala Gly Phe Asn Thr Ala Cys Val Thr Lys Leu Phe Pro Thr
                  85                  90                  95    
 Arg Ser His Thr Val Ala Ala Gln Leu Glu Asn Tyr Gly Met Pro Phe
             100                 105                 110        
 Ser Arg Thr Glu Asp Gly Lys Ile Tyr Gln Arg Ala Phe Gly Gly Gln
         115                 120                 125            
 Ser Leu Lys Phe Gly Lys Gly Gly Gln Ala His Arg Cys Cys Cys Val
     130                 135                 140                
 Ala Asp Arg Thr Gly His Ser Leu Leu His Thr Leu Tyr Gly Arg Ser
 145                 150                 155                 160
 Leu Arg Tyr Asp Thr Ser Tyr Phe Val Glu Tyr Phe Ala Leu Asp Leu
                 165                 170                 175    
 Leu Met Glu Asn Gly Glu Cys Arg Gly Val Ile Ala Leu Cys Ile Glu
             180                 185                 190        
 Asp Gly Ser Ile His Arg Ile Arg Ala Lys Asn Thr Val Val Ala Thr
         195                 200                 205            
 Gly Gly Tyr Gly Arg Thr Tyr Phe Ser Cys Thr Ser Ala His Thr Ser
     210                 215                 220                
 Thr Gly Asp Gly Thr Ala Met Ile Thr Arg Ala Gly Leu Pro Cys Gln
 225                 230                 235                 240
 Asp Leu Glu Phe Val Gln Phe His Pro Thr Gly Ile Tyr Gly Ala Gly
                 245                 250                 255    
 Cys Leu Ile Thr Glu Gly Cys Arg Gly Glu Gly Gly Ile Leu Ile Asn
             260                 265                 270        
 Ser Gln Gly Glu Arg Phe Met Glu Arg Tyr Ala Pro Val Ala Lys Asp
         275                 280                 285            
 Leu Ala Ser Arg Asp Val Val Ser Arg Ser Met Thr Leu Glu Ile Arg
     290                 295                 300                
 Glu Gly Arg Gly Cys Gly Pro Glu Lys Asp His Val Tyr Leu Gln Leu
 305                 310                 315                 320
 His His Leu Pro Pro Glu Gln Leu Ala Thr Arg Leu Pro Gly Ile Ser
                 325                 330                 335    
 Glu Thr Ala Met Ile Phe Ala Gly Val Asp Val Thr Lys Glu Pro Ile
             340                 345                 350        
 Pro Val Leu Pro Thr Val His Tyr Asn Met Gly Gly Ile Pro Thr Asn
         355                 360                 365            
 Tyr Lys Gly Gln Val Leu Arg His Val Asn Gly Gln Asp Gln Ile Val
     370                 375                 380                
 Pro Gly Leu Tyr Ala Cys Gly Glu Ala Ala Cys Ala Ser Val His Gly
 385                 390                 395                 400
 Ala Asn Arg Leu Gly Ala Asn Ser Leu Leu Asp Leu Val Val Phe Gly
                 405                 410                 415    
 Arg Ala Cys Ala Leu Ser Ile Glu Glu Ser Cys Arg Pro Gly Asp Lys
             420                 425                 430        
 Val Pro Pro Ile Lys Pro Asn Ala Gly Glu Glu Ser Val Met Asn Leu
         435                 440                 445            
 Asp Lys Leu Arg Phe Ala Asp Gly Ser Ile Arg Thr Ser Glu Leu Arg
     450                 455                 460                
 Leu Ser Met Gln Lys Ser Met Gln Asn His Ala Ala Val Phe Arg Val
 465                 470                 475                 480
 Gly Ser Val Leu Gln Glu Gly Cys Gly Lys Ile Ser Lys Leu Tyr Gly
                 485                 490                 495    
 Asp Leu Lys His Leu Lys Thr Phe Asp Arg Gly Met Val Trp Asn Thr
             500                 505                 510        
 Asp Leu Val Glu Thr Leu Glu Leu Gln Asn Leu Met Leu Cys Ala Leu
         515                 520                 525            
 Gln Thr Ile Tyr Gly Ala Glu Ala Arg Lys Glu Ser Arg Gly Ala His
     530                 535                 540                
 Ala Arg Glu Asp Tyr Lys Val Arg Ile Asp Glu Tyr Asp Tyr Ser Lys
 545                 550                 555                 560
 Pro Ile Gln Gly Gln Gln Lys Lys Pro Phe Glu Glu His Trp Arg Lys
                 565                 570                 575    
 His Thr Leu Ser Tyr Val Asp Val Gly Thr Gly Lys Val Thr Leu Glu
             580                 585                 590        
 Tyr Arg Pro Val Ile Asp Lys Thr Leu Asn Glu Ala Asp Cys Ala Thr
         595                 600                 605            
 Val Pro Pro Ala Ile Arg Ser Tyr
     610                 615    



      <210> 219
      <211> 150
      <212> PRT
      <213> Homo sapiens


      <400> 219
 Met Ala Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala
   1               5                  10                  15    
 Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu
              20                  25                  30        
 Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu
          35                  40                  45            
 Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile
      50                  55                  60                
 Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr
  65                  70                  75                  80
 Asp Ser Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp
                  85                  90                  95    
 Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn
             100                 105                 110        
 Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu
         115                 120                 125            
 Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln
     130                 135                 140                
 Met Met Thr Ala Lys
 145                



      <210> 220
      <211> 364
      <212> PRT
      <213> Homo sapiens


      <400> 220
 Met Glu Arg Arg Arg Leu Leu Gly Gly Met Ala Leu Leu Leu Leu Gln
   1               5                  10                  15    
 Ala Leu Pro Ser Pro Leu Ser Ala Arg Ala Glu Pro Pro Gln Asp Lys
              20                  25                  30        
 Glu Ala Cys Val Gly Thr Asn Asn Gln Ser Tyr Ile Cys Asp Thr Gly
          35                  40                  45            
 His Cys Cys Gly Gln Ser Gln Cys Cys Asn Tyr Tyr Tyr Glu Leu Trp
      50                  55                  60                
 Trp Phe Trp Leu Val Trp Thr Ile Ile Ile Ile Leu Ser Cys Cys Cys
  65                  70                  75                  80
 Val Cys His His Arg Arg Ala Lys His Arg Leu Gln Ala Gln Gln Arg
                  85                  90                  95    
 Gln His Glu Ile Asn Leu Ile Ala Tyr Arg Glu Ala His Asn Tyr Ser
             100                 105                 110        
 Ala Leu Pro Phe Tyr Phe Arg Phe Leu Pro Asn Tyr Leu Leu Pro Pro
         115                 120                 125            
 Tyr Glu Glu Val Val Asn Arg Pro Pro Thr Pro Pro Pro Pro Tyr Ser
     130                 135                 140                
 Ala Phe Gln Leu Gln Gln Gln Gln Leu Leu Pro Pro Gln Cys Gly Pro
 145                 150                 155                 160
 Ala Gly Gly Ser Pro Pro Gly Ile Asp Pro Thr Arg Gly Ser Gln Gly
                 165                 170                 175    
 Ala Gln Ser Ser Pro Leu Ser Glu Pro Ser Arg Ser Ser Thr Arg Pro
             180                 185                 190        
 Pro Ser Ile Ala Asp Pro Asp Pro Ser Asp Leu Pro Val Asp Arg Ala
         195                 200                 205            
 Ala Thr Lys Ala Pro Gly Met Glu Pro Ser Gly Ser Val Ala Gly Leu
     210                 215                 220                
 Gly Glu Leu Asp Pro Gly Ala Phe Leu Asp Lys Asp Ala Glu Cys Arg
 225                 230                 235                 240
 Glu Glu Leu Leu Lys Asp Asp Ser Ser Glu His Gly Ala Pro Asp Ser
                 245                 250                 255    
 Lys Glu Lys Thr Pro Gly Arg His Arg Arg Phe Thr Gly Asp Ser Gly
             260                 265                 270        
 Ile Glu Val Cys Val Cys Asn Arg Gly His His Asp Asp Asp Leu Lys
         275                 280                 285            
 Glu Phe Asn Thr Leu Ile Asp Asp Ala Leu Asp Gly Pro Leu Asp Phe
     290                 295                 300                
 Cys Asp Ser Cys His Val Arg Pro Pro Gly Asp Glu Glu Glu Gly Leu
 305                 310                 315                 320
 Cys Gln Pro Ser Glu Glu Gln Ala Arg Glu Pro Gly His Pro His Leu
                 325                 330                 335    
 Pro Arg Pro Pro Ala Cys Leu Leu Leu Asn Thr Ile Asn Glu Gln Asp
             340                 345                 350        
 Ser Pro Asn Ser Gln Ser Ser Ser Ser Pro Ser
         355                 360            



      <210> 221
      <211> 367
      <212> PRT
      <213> Homo sapiens


      <400> 221
 Met Ala Thr Pro Asn Asn Leu Thr Pro Thr Asn Cys Ser Trp Trp Pro
   1               5                  10                  15    
 Ile Ser Ala Leu Glu Ser Asp Ala Ala Lys Pro Ala Glu Ala Pro Asp
              20                  25                  30        
 Ala Pro Glu Ala Ala Ser Pro Ala His Trp Pro Arg Glu Ser Leu Val
          35                  40                  45            
 Leu Tyr His Trp Thr Gln Ser Phe Ser Ser Gln Lys Val Arg Leu Val
      50                  55                  60                
 Ile Ala Glu Lys Gly Leu Val Cys Glu Glu Arg Asp Val Ser Leu Pro
  65                  70                  75                  80
 Gln Ser Glu His Lys Glu Pro Trp Phe Met Arg Leu Asn Leu Gly Glu
                  85                  90                  95    
 Glu Val Pro Val Ile Ile His Arg Asp Asn Ile Ile Ser Asp Tyr Asp
             100                 105                 110        
 Gln Ile Ile Asp Tyr Val Glu Arg Thr Phe Thr Gly Glu His Val Val
         115                 120                 125            
 Ala Leu Met Pro Glu Val Gly Ser Leu Gln His Ala Arg Val Leu Gln
     130                 135                 140                
 Tyr Arg Glu Leu Leu Asp Ala Leu Pro Met Asp Ala Tyr Thr His Gly
 145                 150                 155                 160
 Cys Ile Leu His Pro Glu Leu Thr Thr Asp Ser Met Ile Pro Lys Tyr
                 165                 170                 175    
 Ala Thr Ala Glu Ile Arg Arg His Leu Ala Asn Ala Thr Thr Asp Leu
             180                 185                 190        
 Met Lys Leu Asp His Glu Glu Glu Pro Gln Leu Ser Glu Pro Tyr Leu
         195                 200                 205            
 Ser Lys Gln Lys Lys Leu Met Ala Lys Ile Leu Glu His Asp Asp Val
     210                 215                 220                
 Ser Tyr Leu Lys Lys Ile Leu Gly Glu Leu Ala Met Val Leu Asp Gln
 225                 230                 235                 240
 Ile Glu Ala Glu Leu Glu Lys Arg Lys Leu Glu Asn Glu Gly Gln Lys
                 245                 250                 255    
 Cys Glu Leu Trp Leu Cys Gly Cys Ala Phe Thr Leu Ala Asp Val Leu
             260                 265                 270        
 Leu Gly Ala Thr Leu His Arg Leu Lys Phe Leu Gly Leu Ser Lys Lys
         275                 280                 285            
 Tyr Trp Glu Asp Gly Ser Arg Pro Asn Leu Gln Ser Phe Phe Glu Arg
     290                 295                 300                
 Val Gln Arg Arg Phe Ala Phe Arg Lys Val Leu Gly Asp Ile His Thr
 305                 310                 315                 320
 Thr Leu Leu Ser Ala Val Ile Pro Asn Ala Phe Arg Leu Val Lys Arg
                 325                 330                 335    
 Lys Pro Pro Ser Phe Phe Gly Ala Ser Phe Leu Met Gly Ser Leu Gly
             340                 345                 350        
 Gly Met Gly Tyr Phe Ala Tyr Trp Tyr Leu Lys Lys Lys Tyr Ile
         355                 360                 365        



      <210> 222
      <211> 3008
      <212> PRT
      <213> Homo sapiens


      <400> 222
 Met Leu Ala Arg Ala Ala Arg Gly Thr Gly Ala Leu Leu Leu Arg Gly
   1               5                  10                  15    
 Ser Leu Leu Ala Ser Gly Arg Ala Pro Arg Arg Ala Ser Ser Gly Leu
              20                  25                  30        
 Pro Arg Asn Thr Val Val Leu Phe Val Pro Gln Gln Glu Ala Trp Val
          35                  40                  45            
 Val Glu Arg Met Gly Arg Phe His Arg Ile Leu Glu Pro Gly Leu Asn
      50                  55                  60                
 Ile Leu Ile Pro Val Leu Asp Arg Ile Arg Tyr Val Gln Ser Leu Lys
  65                  70                  75                  80
 Glu Ile Val Ile Asn Val Pro Glu Gln Ser Ala Val Thr Leu Asp Asn
                  85                  90                  95    
 Val Thr Leu Gln Ile Asp Gly Val Leu Tyr Leu Arg Ile Met Asp Pro
             100                 105                 110        
 Tyr Lys Ala Ser Tyr Gly Val Glu Asp Pro Glu Tyr Ala Val Thr Gln
         115                 120                 125            
 Leu Ala Gln Thr Thr Met Arg Ser Glu Leu Gly Lys Leu Ser Leu Asp
     130                 135                 140                
 Lys Val Phe Arg Glu Arg Glu Ser Leu Asn Ala Ser Ile Val Asp Ala
 145                 150                 155                 160
 Ile Asn Gln Ala Ala Asp Cys Trp Gly Ile Arg Cys Leu Arg Tyr Glu
                 165                 170                 175    
 Ile Lys Asp Ile His Val Pro Pro Arg Val Lys Glu Ser Met Gln Met
             180                 185                 190        
 Gln Val Glu Ala Glu Arg Arg Lys Arg Ala Thr Val Leu Glu Ser Glu
         195                 200                 205            
 Gly Thr Arg Glu Ser Ala Ile Asn Val Ala Glu Gly Lys Lys Gln Ala
     210                 215                 220                
 Gln Ile Leu Ala Ser Glu Ala Glu Lys Ala Glu Gln Ile Asn Gln Ala
 225                 230                 235                 240
 Ala Gly Glu Ala Ser Ala Val Leu Ala Lys Ala Lys Ala Lys Ala Glu
                 245                 250                 255    
 Ala Ile Arg Ile Leu Ala Ala Ala Leu Thr Gln His Asn Gly Asp Ala
             260                 265                 270        
 Ala Ala Ser Leu Thr Val Ala Glu Gln Tyr Val Ser Ala Phe Ser Lys
         275                 280                 285            
 Leu Ala Lys Asp Ser Asn Thr Ile Leu Leu Pro Ser Asn Pro Gly Asp
     290                 295                 300                
 Val Thr Ser Met Val Ala Gln Ala Met Gly Val Tyr Gly Ala Leu Thr
 305                 310                 315                 320
 Lys Ala Pro Val Pro Gly Thr Pro Asp Ser Leu Ser Ser Gly Ser Ser
                 325                 330                 335    
 Arg Asp Val Gln Gly Thr Asp Ala Ser Leu Asp Glu Glu Leu Asp Arg
             340                 345                 350        
 Val Lys Met Thr Trp Ser Pro Val Pro Asn Phe Gln Leu Leu Asn Ile
         355                 360                 365            
 Pro Ser Asn Trp Gly Gln Pro His Ala Pro Gly Gln Thr Ser Thr Glu
     370                 375                 380                
 Val Pro Ala Asp Gly Asp Gly Ala Thr Asp Gly Pro Leu Cys Leu Ala
 385                 390                 395                 400
 His Ala Ser Leu Cys Cys Gln Val Ala Gly Ala Ala Ala Ala Ala Leu
                 405                 410                 415    
 Pro Gly Ala Ile Ala Gly Gly Ala Val Gly Trp Ala Arg Ile Pro Leu
             420                 425                 430        
 Arg Leu Arg Ser Leu Ser Thr Gly Met Gln Lys Ala Ser Val Leu Leu
         435                 440                 445            
 Phe Leu Ala Trp Val Cys Phe Leu Phe Tyr Ala Gly Ile Ala Leu Phe
     450                 455                 460                
 Thr Ser Gly Phe Leu Leu Thr Arg Leu Glu Leu Thr Asn His Ser Ser
 465                 470                 475                 480
 Cys Gln Glu Pro Pro Gly Pro Gly Ser Leu Pro Trp Gly Ser Gln Gly
                 485                 490                 495    
 Lys Pro Gly Ala Cys Trp Met Ala Ser Arg Phe Ser Arg Val Val Leu
             500                 505                 510        
 Val Leu Ile Asp Ala Leu Arg Phe Asp Phe Ala Gln Pro Gln His Ser
         515                 520                 525            
 His Val Pro Arg Glu Pro Pro Val Ser Leu Pro Phe Leu Gly Lys Leu
     530                 535                 540                
 Ser Ser Leu Gln Arg Ile Leu Glu Ile Gln Pro His His Ala Arg Leu
 545                 550                 555                 560
 Tyr Arg Ser Gln Val Asp Pro Pro Thr Thr Thr Met Gln Arg Leu Lys
                 565                 570                 575    
 Ala Leu Thr Thr Gly Ser Leu Pro Thr Phe Ile Asp Ala Gly Ser Asn
             580                 585                 590        
 Phe Ala Ser His Ala Ile Val Glu Asp Asn Leu Ile Lys Gln Leu Thr
         595                 600                 605            
 Ser Ala Gly Arg Arg Val Val Phe Met Gly Asp Asp Thr Trp Lys Asp
     610                 615                 620                
 Leu Phe Pro Gly Ala Phe Ser Lys Ala Phe Phe Phe Pro Ser Phe Asn
 625                 630                 635                 640
 Val Arg Asp Leu Asp Thr Val Asp Asn Gly Ile Leu Glu His Leu Tyr
                 645                 650                 655    
 Pro Thr Met Asp Ser Gly Glu Trp Asp Val Leu Ile Ala His Phe Leu
             660                 665                 670        
 Gly Val Asp His Cys Gly His Lys His Gly Pro His His Pro Glu Met
         675                 680                 685            
 Ala Lys Lys Leu Ser Gln Met Asp Gln Val Ile Gln Gly Leu Val Glu
     690                 695                 700                
 Arg Leu Glu Asn Asp Thr Leu Leu Val Val Ala Gly Asp His Gly Met
 705                 710                 715                 720
 Thr Thr Asn Gly Asp His Gly Gly Asp Ser Glu Leu Glu Val Ser Ala
                 725                 730                 735    
 Ala Leu Phe Leu Tyr Ser Pro Thr Ala Val Phe Pro Ser Thr Pro Pro
             740                 745                 750        
 Glu Glu Pro Glu Val Ile Pro Gln Val Ser Leu Val Pro Thr Leu Ala
         755                 760                 765            
 Leu Leu Leu Gly Leu Pro Ile Pro Phe Gly Asn Ile Gly Glu Val Met
     770                 775                 780                
 Ala Glu Leu Phe Ser Gly Gly Glu Asp Ser Gln Pro His Ser Ser Ala
 785                 790                 795                 800
 Leu Ala Gln Ala Ser Ala Leu His Leu Asn Ala Gln Gln Val Ser Arg
                 805                 810                 815    
 Phe Leu His Thr Tyr Ser Ala Ala Thr Gln Asp Leu Gln Ala Lys Glu
             820                 825                 830        
 Leu His Gln Leu Gln Asn Leu Phe Ser Lys Ala Ser Ala Asp Tyr Gln
         835                 840                 845            
 Trp Leu Leu Gln Ser Pro Lys Gly Ala Glu Ala Thr Leu Pro Thr Val
     850                 855                 860                
 Ile Ala Glu Leu Gln Gln Phe Leu Arg Gly Ala Arg Ala Met Cys Ile
 865                 870                 875                 880
 Glu Ser Trp Ala Arg Phe Ser Leu Val Arg Met Ala Gly Gly Thr Ala
                 885                 890                 895    
 Leu Leu Ala Ala Ser Cys Phe Ile Cys Leu Leu Ala Ser Gln Trp Ala
             900                 905                 910        
 Ile Ser Pro Gly Phe Pro Phe Cys Pro Leu Leu Leu Thr Pro Val Ala
         915                 920                 925            
 Trp Gly Leu Val Gly Ala Ile Ala Tyr Ala Gly Leu Leu Gly Thr Ile
     930                 935                 940                
 Glu Leu Lys Leu Asp Leu Val Leu Leu Gly Ala Val Ala Ala Val Ser
 945                 950                 955                 960
 Ser Phe Leu Pro Phe Leu Trp Lys Ala Trp Ala Gly Trp Gly Ser Lys
                 965                 970                 975    
 Arg Pro Leu Ala Thr Leu Phe Pro Ile Pro Gly Pro Val Leu Leu Leu
             980                 985                 990        
 Leu Leu Phe Arg Leu Ala Val Phe Phe Ser Asp Ser Phe Val Val Ala
         995                1000                1005            
 Glu Ala Arg Ala Thr Pro Phe Leu Leu Gly Ser Phe Ile Leu Leu Leu
    1010                1015                1020                
 Val Val Gln Leu His Trp Glu Gly Gln Leu Leu Pro Pro Lys Leu Leu
1025                1030                1035                1040
 Thr Met Pro Arg Leu Gly Thr Ser Ala Thr Thr Asn Pro Pro Arg His
                1045                1050                1055    
 Asn Gly Ala Tyr Ala Leu Arg Leu Gly Ile Gly Leu Leu Leu Cys Thr
            1060                1065                1070        
 Arg Leu Ala Gly Leu Phe His Arg Cys Pro Glu Glu Thr Pro Val Cys
        1075                1080                1085            
 His Ser Ser Pro Trp Leu Ser Pro Leu Ala Ser Met Val Gly Gly Arg
    1090                1095                1100                
 Ala Lys Asn Leu Trp Tyr Gly Ala Cys Val Ala Ala Leu Val Ala Leu
1105                1110                1115                1120
 Leu Ala Ala Val Arg Leu Trp Leu Arg Arg Tyr Gly Asn Leu Lys Ser
                1125                1130                1135    
 Pro Glu Pro Pro Met Leu Phe Val Arg Trp Gly Leu Pro Leu Met Ala
            1140                1145                1150        
 Leu Gly Thr Ala Ala Tyr Trp Ala Leu Ala Ser Gly Ala Asp Glu Ala
        1155                1160                1165            
 Pro Pro Arg Leu Arg Val Leu Val Ser Gly Ala Ser Met Val Leu Pro
    1170                1175                1180                
 Arg Ala Val Ala Gly Leu Ala Ala Ser Gly Leu Ala Leu Leu Leu Trp
1185                1190                1195                1200
 Lys Pro Val Thr Val Leu Val Lys Ala Gly Ala Gly Ala Pro Arg Thr
                1205                1210                1215    
 Arg Thr Val Leu Thr Pro Phe Ser Gly Pro Pro Thr Ser Gln Ala Asp
            1220                1225                1230        
 Leu Asp Tyr Val Val Pro Gln Ile Tyr Arg His Met Gln Glu Glu Phe
        1235                1240                1245            
 Arg Gly Arg Leu Glu Arg Thr Lys Ser Gln Gly Pro Leu Thr Val Ala
    1250                1255                1260                
 Ala Tyr Gln Leu Gly Ser Val Tyr Ser Ala Ala Met Val Thr Ala Leu
1265                1270                1275                1280
 Thr Leu Leu Ala Phe Pro Leu Leu Leu Leu His Ala Glu Arg Ile Ser
                1285                1290                1295    
 Leu Val Phe Leu Leu Leu Phe Leu Gln Ser Phe Leu Leu Leu His Leu
            1300                1305                1310        
 Leu Ala Ala Gly Ile Pro Val Thr Thr Pro Gly Lys Tyr Leu Ser Ser
        1315                1320                1325            
 Asp Ser Leu Lys Asp Asn Ser Asp Ser Gln Gly Leu Arg Lys Arg Gln
    1330                1335                1340                
 Gln Pro Pro Gly Asn Glu Ala Asp Ala Arg Val Arg Pro Glu Glu Glu
1345                1350                1355                1360
 Glu Glu Pro Leu Met Glu Met Arg Leu Arg Asp Ala Pro Gln His Phe
                1365                1370                1375    
 Tyr Ala Ala Leu Leu Gln Leu Gly Leu Lys Tyr Leu Phe Ile Leu Gly
            1380                1385                1390        
 Ile Gln Ile Leu Ala Cys Ala Leu Ala Ala Ser Ile Leu Arg Arg His
        1395                1400                1405            
 Leu Met Val Trp Lys Val Phe Ala Pro Lys Phe Ile Phe Glu Ala Val
    1410                1415                1420                
 Gly Phe Ile Val Ser Ser Val Gly Leu Leu Leu Gly Ile Ala Leu Val
1425                1430                1435                1440
 Met Arg Val Asp Gly Ala Val Leu Leu Ser Ser Ala Ser Thr Glu Arg
                1445                1450                1455    
 His Cys Gln Gln Thr Thr Arg Gly Arg Lys Pro Thr Leu Val Ser Val
            1460                1465                1470        
 Leu Val Leu Asp Ser Glu Gln Arg Lys Asp Gly Arg Leu Arg Ser Ala
        1475                1480                1485            
 Leu Val Ser Ser Tyr Arg Phe Leu Glu Thr Pro Ser Ala Gly Ala Glu
    1490                1495                1500                
 Leu Phe Arg Pro Ala Ser Ala Thr Met Ser Arg Gln Thr Thr Ser Val
1505                1510                1515                1520
 Gly Ser Ser Cys Leu Asp Leu Trp Arg Glu Lys Asn Asp Arg Leu Val
                1525                1530                1535    
 Arg Gln Ala Lys Val Ala Gln Asn Ser Gly Leu Thr Leu Arg Arg Gln
            1540                1545                1550        
 Gln Leu Ala Gln Asp Ala Leu Glu Gly Leu Arg Gly Leu Leu His Ser
        1555                1560                1565            
 Leu Gln Gly Leu Pro Ala Ala Val Pro Val Leu Pro Leu Glu Leu Thr
    1570                1575                1580                
 Val Thr Cys Asn Phe Ile Ile Leu Arg Ala Ser Leu Ala Gln Gly Phe
1585                1590                1595                1600
 Thr Glu Asp Gln Ala Gln Asp Ile Gln Arg Ser Leu Glu Arg Val Leu
                1605                1610                1615    
 Glu Thr Gln Glu Gln Gln Gly Pro Arg Leu Glu Gln Gly Leu Arg Glu
            1620                1625                1630        
 Leu Trp Asp Ser Val Leu Arg Ala Ser Cys Leu Leu Pro Glu Leu Leu
        1635                1640                1645            
 Ser Ala Leu His Arg Leu Val Gly Leu Gln Ala Ala Leu Trp Leu Ser
    1650                1655                1660                
 Ala Asp Arg Leu Gly Asp Leu Ala Leu Leu Leu Glu Thr Leu Asn Gly
1665                1670                1675                1680
 Ser Gln Ser Gly Ala Ser Lys Asp Leu Leu Leu Leu Leu Lys Thr Trp
                1685                1690                1695    
 Ser Pro Pro Ala Glu Glu Leu Asp Ala Pro Leu Thr Leu Gln Asp Ala
            1700                1705                1710        
 Gln Gly Leu Lys Asp Val Leu Leu Thr Ala Phe Ala Tyr Arg Gln Gly
        1715                1720                1725            
 Leu Gln Glu Leu Ile Thr Gly Asn Pro Asp Lys Ala Leu Ser Ser Leu
    1730                1735                1740                
 His Glu Ala Ala Ser Gly Leu Cys Pro Arg Pro Val Leu Val Gln Val
1745                1750                1755                1760
 Tyr Thr Ala Leu Gly Ser Cys His Arg Lys Met Gly Asn Pro Gln Arg
                1765                1770                1775    
 Ala Leu Leu Tyr Leu Val Ala Ala Leu Lys Glu Gly Ser Ala Trp Gly
            1780                1785                1790        
 Pro Pro Leu Leu Glu Ala Ser Arg Leu Tyr Gln Gln Leu Gly Asp Thr
        1795                1800                1805            
 Thr Ala Glu Leu Glu Ser Leu Glu Leu Leu Val Glu Ala Leu Asn Val
    1810                1815                1820                
 Pro Cys Ser Ser Lys Ala Pro Gln Phe Leu Ile Glu Val Glu Leu Leu
1825                1830                1835                1840
 Leu Pro Pro Pro Asp Leu Ala Ser Pro Leu His Cys Gly Thr Gln Ser
                1845                1850                1855    
 Gln Thr Lys His Ile Leu Ala Ser Arg Cys Leu Gln Thr Gly Arg Ala
            1860                1865                1870        
 Gly Asp Ala Ala Glu His Tyr Leu Asp Leu Leu Ala Leu Leu Leu Asp
        1875                1880                1885            
 Ser Ser Glu Pro Arg Val Gly Pro Cys Met Pro Glu Val Phe Leu Glu
    1890                1895                1900                
 Ala Ala Val Ala Leu Ile Gln Ala Gly Arg Ala Gln Asp Ala Leu Thr
1905                1910                1915                1920
 Leu Cys Glu Glu Leu Leu Ser Arg Thr Ser Ser Leu Leu Pro Lys Met
                1925                1930                1935    
 Ser Arg Leu Trp Glu Asp Ala Arg Lys Gly Thr Lys Glu Leu Pro Tyr
            1940                1945                1950        
 Cys Pro Leu Trp Val Ser Ala Thr His Leu Leu Gln Gly Gln Ala Trp
        1955                1960                1965            
 Val Gln Leu Gly Ala Gln Lys Val Ala Ile Ser Glu Phe Ser Arg Cys
    1970                1975                1980                
 Leu Glu Leu Leu Phe Arg Ala Thr Pro Glu Glu Lys Glu Gln Gly Ala
1985                1990                1995                2000
 Ala Phe Asn Cys Glu Gln Gly Cys Lys Ser Asp Ala Ala Leu Gln Gln
                2005                2010                2015    
 Leu Arg Ala Ala Ala Leu Ile Ser Arg Gly Leu Glu Trp Val Ala Ser
            2020                2025                2030        
 Gly Gln Asp Thr Lys Ala Leu Gln Asp Phe Leu Leu Ser Val Gln Met
        2035                2040                2045            
 Cys Pro Val Ser Ala Lys Arg Leu Arg Pro Ser Phe Glu Ser Ser Leu
    2050                2055                2060                
 Pro Leu Pro Leu Pro Leu Pro Leu Pro Pro Arg Gly Ser Gly Ala Ser
2065                2070                2075                2080
 Val Val Arg Pro Thr Pro Arg Cys Arg Pro Arg Pro Ala Arg Leu Ala
                2085                2090                2095    
 Pro Leu Glu Arg Thr Ser Gly Pro Gly Gln Val Phe Arg Pro Thr Pro
            2100                2105                2110        
 Pro Gly Arg Arg Pro Gly Ala Leu Gly Arg Gln Ser Ala Val Arg Pro
        2115                2120                2125            
 Thr Thr Arg Arg Lys Pro Leu Val Pro Gly Glu Ser Arg Pro Arg Glu
    2130                2135                2140                
 Pro Glu Ala Pro Ala Gly Pro Glu Glu Asp Ile Lys Val Gln Arg Leu
2145                2150                2155                2160
 Gly Asn Leu Pro Lys Ile Thr Ile Lys Gln Trp His Asn Trp Asn Ser
                2165                2170                2175    
 Asp Pro Met Gly Leu Thr Ile Glu Phe Leu Leu Leu Thr Thr Leu Leu
            2180                2185                2190        
 Ser Lys Gly Asp Asp Leu Ser Thr Ala Ile Leu Lys Gln Lys Asn Arg
        2195                2200                2205            
 Pro Asn Arg Leu Ile Val Asp Glu Ala Ile Asn Glu Asp Asn Ser Val
    2210                2215                2220                
 Val Ser Leu Ser Gln Pro Lys Met Asp Glu Leu Gln Leu Phe Arg Gly
2225                2230                2235                2240
 Asp Thr Val Leu Leu Lys Gly Lys Lys Arg Arg Glu Ala Val Cys Ile
                2245                2250                2255    
 Val Leu Ser Asp Asp Thr Cys Ser Asp Glu Lys Ile Arg Met Asn Arg
            2260                2265                2270        
 Val Val Arg Asn Asn Leu Arg Val Arg Leu Gly Asp Val Ile Ser Ile
        2275                2280                2285            
 Gln Pro Cys Pro Asp Val Lys Tyr Gly Lys Arg Ile His Val Leu Pro
    2290                2295                2300                
 Ile Asp Asp Thr Val Glu Gly Ile Thr Gly Asn Leu Phe Glu Val Tyr
2305                2310                2315                2320
 Leu Lys Pro Tyr Phe Leu Glu Ala Tyr Arg Pro Ile Arg Lys Gly Asp
                2325                2330                2335    
 Ile Phe Leu Val Arg Gly Gly Met Arg Ala Val Glu Phe Lys Val Val
            2340                2345                2350        
 Glu Thr Asp Pro Ser Pro Tyr Cys Ile Val Ala Pro Asp Thr Val Ile
        2355                2360                2365            
 His Cys Glu Gly Glu Pro Ile Lys Arg Glu Asp Glu Glu Glu Ser Leu
    2370                2375                2380                
 Asn Glu Val Gly Tyr Asp Asp Ile Gly Gly Cys Arg Lys Gln Leu Ala
2385                2390                2395                2400
 Gln Ile Lys Glu Met Val Glu Leu Pro Leu Arg His Pro Ala Leu Phe
                2405                2410                2415    
 Lys Ala Ile Gly Val Lys Pro Pro Arg Gly Ile Leu Leu Tyr Gly Pro
            2420                2425                2430        
 Pro Gly Thr Gly Lys Thr Leu Ile Ala Arg Ala Val Ala Asn Glu Thr
        2435                2440                2445            
 Gly Ala Phe Phe Phe Leu Ile Asn Gly Pro Glu Ile Met Ser Lys Leu
    2450                2455                2460                
 Ala Gly Glu Ser Glu Ser Asn Leu Arg Lys Ala Phe Glu Glu Ala Glu
2465                2470                2475                2480
 Lys Asn Ala Pro Ala Ile Ile Phe Ile Asp Glu Leu Asp Ala Ile Ala
                2485                2490                2495    
 Pro Lys Arg Glu Lys Thr His Gly Glu Val Glu Arg Arg Ile Val Ser
            2500                2505                2510        
 Gln Leu Leu Thr Leu Met Asp Gly Leu Lys Gln Arg Ala His Val Ile
        2515                2520                2525            
 Val Met Ala Ala Thr Asn Arg Pro Asn Ser Ile Asp Pro Ala Leu Arg
    2530                2535                2540                
 Arg Phe Gly Arg Phe Asp Arg Glu Val Asp Ile Gly Ile Pro Asp Ala
2545                2550                2555                2560
 Thr Gly Arg Leu Glu Ile Leu Gln Ile His Thr Lys Asn Met Lys Leu
                2565                2570                2575    
 Ala Asp Asp Val Asp Leu Glu Gln Val Ala Asn Glu Thr His Gly His
            2580                2585                2590        
 Val Gly Ala Asp Leu Ala Ala Leu Cys Ser Glu Ala Ala Leu Gln Ala
        2595                2600                2605            
 Ile Arg Lys Lys Met Asp Leu Ile Asp Leu Glu Asp Glu Thr Ile Asp
    2610                2615                2620                
 Ala Glu Val Met Asn Ser Leu Ala Val Thr Met Asp Asp Phe Arg Val
2625                2630                2635                2640
 Arg Thr Thr Pro Val Pro Gln Trp Ala Leu Ser Gln Ser Asn Pro Ser
                2645                2650                2655    
 Ala Leu Arg Glu Thr Val Val Glu Val Pro Gln Val Thr Trp Glu Asp
            2660                2665                2670        
 Ile Gly Gly Leu Glu Asp Val Lys Arg Glu Leu Gln Glu Leu Val Gln
        2675                2680                2685            
 Tyr Pro Val Glu His Pro Asp Lys Phe Leu Lys Phe Gly Met Thr Pro
    2690                2695                2700                
 Ser Lys Gly Val Leu Phe Tyr Gly Pro Pro Gly Cys Gly Lys Thr Leu
2705                2710                2715                2720
 Leu Ala Lys Ala Ile Ala Asn Glu Cys Gln Ala Asn Phe Ile Ser Ile
                2725                2730                2735    
 Lys Gly Pro Glu Leu Leu Thr Met Trp Phe Gly Glu Ser Glu Ala Asn
            2740                2745                2750        
 Val Arg Glu Ile Phe Asp Lys Ala Arg Gln Ala Ala Pro Cys Val Leu
        2755                2760                2765            
 Phe Phe Asp Glu Leu Asp Ser Ile Ala Lys Ala Arg Gly Gly Asn Ile
    2770                2775                2780                
 Gly Asp Gly Gly Gly Ala Ala Asp Arg Val Ile Asn Gln Ile Leu Thr
2785                2790                2795                2800
 Glu Met Asp Gly Met Ser Thr Lys Lys Asn Val Phe Ile Ile Gly Ala
                2805                2810                2815    
 Thr Asn Arg Pro Asp Ile Ile Asp Pro Ala Ile Leu Arg Pro Gly Arg
            2820                2825                2830        
 Leu Asp Gln Leu Ile Tyr Ile Pro Leu Pro Asp Glu Lys Ser Arg Val
        2835                2840                2845            
 Ala Ile Leu Lys Ala Asn Leu Arg Lys Ser Pro Val Ala Lys Ala Gly
    2850                2855                2860                
 Ala Arg Ser Trp Ala Asp Val Asp Leu Glu Phe Leu Ala Lys Met Thr
2865                2870                2875                2880
 Asn Gly Phe Ser Gly Ala Asp Leu Thr Glu Ile Cys Gln Arg Ala Cys
                2885                2890                2895    
 Lys Leu Ala Ile Arg Glu Ser Ile Glu Ser Glu Ile Arg Arg Glu Arg
            2900                2905                2910        
 Glu Arg Gln Thr Asn Pro Ser Ala Met Glu Val Glu Glu Asp Asp Pro
        2915                2920                2925            
 Val Pro Glu Ile Arg Arg Asp His Phe Glu Glu Ala Met Arg Phe Ala
    2930                2935                2940                
 Arg Arg Ser Val Ser Asp Asn Asp Ile Arg Lys Tyr Glu Met Phe Ala
2945                2950                2955                2960
 Gln Thr Leu Gln Gln Ser Arg Gly Phe Gly Ser Phe Arg Phe Pro Ser
                2965                2970                2975    
 Gly Asn Gln Gly Gly Ala Gly Pro Ser Gln Gly Ser Gly Gly Gly Thr
            2980                2985                2990        
 Gly Gly Ser Val Tyr Thr Glu Asp Asn Asp Asp Asp Leu Tyr Gly
        2995                3000                3005        



      <210> 223
      <211> 154
      <212> PRT
      <213> Homo sapiens


      <400> 223
 Met Val Glu Lys Lys Thr Ser Val Arg Ser Gln Asp Pro Gly Gln Arg
   1               5                  10                  15    
 Arg Val Leu Asp Arg Ala Ala Arg Gln Arg Arg Ile Asn Arg Gln Leu
              20                  25                  30        
 Glu Ala Leu Glu Asn Asp Asn Phe Gln Asp Asp Pro His Ala Gly Leu
          35                  40                  45            
 Pro Gln Leu Gly Lys Arg Leu Pro Gln Phe Asp Asp Asp Ala Asp Thr
      50                  55                  60                
 Gly Lys Lys Lys Lys Lys Thr Arg Gly Asp His Phe Lys Leu Arg Phe
  65                  70                  75                  80
 Arg Lys Asn Phe Gln Ala Leu Leu Glu Glu Gln Asn Leu Ser Val Ala
                  85                  90                  95    
 Glu Gly Pro Asn Tyr Leu Thr Ala Cys Ala Gly Pro Pro Ser Arg Pro
             100                 105                 110        
 Gln Arg Pro Phe Cys Ala Val Cys Gly Phe Pro Ser Pro Tyr Thr Cys
         115                 120                 125            
 Val Ser Cys Gly Ala Arg Tyr Cys Thr Val Arg Cys Leu Gly Thr His
     130                 135                 140                
 Gln Glu Thr Arg Cys Leu Lys Trp Thr Val
 145                 150                



      <210> 224
      <211> 194
      <212> PRT
      <213> Homo sapiens


      <400> 224
 Met Pro Asn Trp Gly Gly Gly Ala Lys Cys Gly Ala Cys Glu Lys Thr
   1               5                  10                  15    
 Val Tyr His Ala Glu Glu Ile Gln Cys Asn Gly Arg Ser Phe His Lys
              20                  25                  30        
 Thr Cys Phe His Cys Met Ala Cys Arg Lys Ala Leu Asp Ser Thr Thr
          35                  40                  45            
 Val Ala Ala His Glu Ser Glu Ile Tyr Cys Lys Val Cys Tyr Gly Arg
      50                  55                  60                
 Arg Tyr Gly Pro Lys Gly Ile Gly Tyr Gly Gln Gly Ala Gly Cys Leu
  65                  70                  75                  80
 Ser Thr Asp Thr Gly Glu His Leu Gly Leu Gln Phe Gln Gln Ser Pro
                  85                  90                  95    
 Lys Pro Ala Arg Ser Val Thr Thr Ser Asn Pro Ser Lys Phe Thr Ala
             100                 105                 110        
 Lys Phe Gly Glu Ser Glu Lys Cys Pro Arg Cys Gly Lys Ser Val Tyr
         115                 120                 125            
 Ala Ala Glu Lys Val Met Gly Gly Gly Lys Pro Trp His Lys Thr Cys
     130                 135                 140                
 Phe Arg Cys Ala Ile Cys Gly Lys Ser Leu Glu Ser Thr Asn Val Thr
 145                 150                 155                 160
 Asp Lys Asp Gly Glu Leu Tyr Cys Lys Val Cys Tyr Ala Lys Asn Phe
                 165                 170                 175    
 Gly Pro Thr Gly Ile Gly Phe Gly Gly Leu Thr Gln Gln Val Glu Lys
             180                 185                 190        
 Lys Glu
        



      <210> 225
      <211> 222
      <212> PRT
      <213> Homo sapiens


      <400> 225
 Met Phe His Gly Ile Pro Ala Thr Pro Gly Ile Gly Ala Pro Gly Asn
   1               5                  10                  15    
 Lys Pro Glu Leu Tyr Glu Glu Val Lys Leu Tyr Lys Asn Ala Arg Glu
              20                  25                  30        
 Arg Glu Lys Tyr Asp Asn Met Ala Glu Leu Phe Ala Val Val Lys Thr
          35                  40                  45            
 Met Gln Ala Leu Glu Lys Ala Tyr Ile Lys Asp Cys Val Ser Pro Ser
      50                  55                  60                
 Glu Tyr Thr Ala Ala Cys Ser Arg Leu Leu Val Gln Tyr Lys Ala Ala
  65                  70                  75                  80
 Phe Arg Gln Val Gln Gly Ser Glu Ile Ser Ser Ile Asp Glu Phe Cys
                  85                  90                  95    
 Arg Lys Phe Arg Leu Asp Cys Pro Leu Ala Met Glu Arg Ile Lys Glu
             100                 105                 110        
 Asp Arg Pro Ile Thr Ile Lys Asp Asp Lys Gly Asn Leu Asn Arg Cys
         115                 120                 125            
 Ile Ala Asp Val Val Ser Leu Phe Ile Thr Val Met Asp Lys Leu Arg
     130                 135                 140                
 Leu Glu Ile Arg Ala Met Asp Glu Ile Gln Pro Asp Leu Arg Glu Leu
 145                 150                 155                 160
 Met Glu Thr Met His Arg Met Ser His Leu Pro Pro Asp Phe Glu Gly
                 165                 170                 175    
 Arg Gln Thr Val Ser Gln Trp Leu Gln Thr Leu Ser Gly Met Ser Ala
             180                 185                 190        
 Ser Asp Glu Leu Asp Asp Ser Gln Val Arg Gln Met Leu Phe Asp Leu
         195                 200                 205            
 Glu Ser Ala Tyr Asn Ala Phe Asn Arg Phe Leu His Ala
     210                 215                 220    



      <210> 226
      <211> 228
      <212> PRT
      <213> Homo sapiens


      <400> 226
 Met Asn Ile Lys Gly Ser Pro Trp Lys Gly Ser Leu Leu Leu Leu Leu
   1               5                  10                  15    
 Val Ser Asn Leu Leu Leu Cys Gln Ser Val Ala Pro Leu Pro Ile Cys
              20                  25                  30        
 Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp
          35                  40                  45            
 Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ser Ser Glu Met
      50                  55                  60                
 Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr
  65                  70                  75                  80
 Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala Thr Pro Glu Asp
                  85                  90                  95    
 Lys Glu Gln Ala Gln Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile
             100                 105                 110        
 Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr
         115                 120                 125            
 Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala
     130                 135                 140                
 Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Gly Met Glu Leu
 145                 150                 155                 160
 Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro
                 165                 170                 175    
 Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg
             180                 185                 190        
 Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His
         195                 200                 205            
 Lys Ile Asp Asn Tyr Leu Lys Leu Leu Lys Cys Arg Ile Ile His Asn
     210                 215                 220                
 Asn Asn Cys
 225        



      <210> 227
      <211> 519
      <212> PRT
      <213> Homo sapiens


      <400> 227
 Met Thr Val Val Glu Glu Ala Asp Asp Asp Lys Lys Arg Leu Leu Gln
   1               5                  10                  15    
 Ile Ile Asp Arg Asp Gly Glu Glu Glu Glu Glu Glu Glu Glu Pro Leu
              20                  25                  30        
 Asp Glu Ser Ser Val Lys Lys Met Ile Leu Thr Phe Glu Lys Arg Ser
          35                  40                  45            
 Tyr Lys Asn Gln Glu Leu Arg Ile Lys Phe Pro Asp Asn Pro Glu Lys
      50                  55                  60                
 Phe Met Glu Ser Glu Leu Asp Leu Asn Asp Ile Ile Gln Glu Met His
  65                  70                  75                  80
 Val Val Ala Thr Met Pro Asp Leu Tyr His Leu Leu Val Glu Leu Asn
                  85                  90                  95    
 Ala Val Gln Ser Leu Leu Gly Leu Leu Gly His Asp Asn Thr Asp Val
             100                 105                 110        
 Ser Ile Ala Val Val Asp Leu Leu Gln Glu Leu Thr Asp Ile Asp Thr
         115                 120                 125            
 Leu His Glu Ser Glu Glu Gly Ala Glu Val Leu Ile Asp Ala Leu Val
     130                 135                 140                
 Asp Gly Gln Val Val Ala Leu Leu Val Gln Asn Leu Glu Arg Leu Asp
 145                 150                 155                 160
 Glu Ser Val Lys Glu Glu Ala Asp Gly Val His Asn Thr Leu Ala Ile
                 165                 170                 175    
 Val Glu Asn Met Ala Glu Phe Arg Pro Glu Met Cys Thr Glu Gly Ala
             180                 185                 190        
 Gln Gln Gly Leu Leu Gln Trp Leu Leu Lys Arg Leu Lys Ala Lys Met
         195                 200                 205            
 Pro Phe Asp Ala Asn Lys Leu Tyr Cys Ser Glu Val Leu Ala Ile Leu
     210                 215                 220                
 Leu Gln Asp Asn Asp Glu Asn Arg Glu Leu Leu Gly Glu Leu Asp Gly
 225                 230                 235                 240
 Ile Asp Val Leu Leu Gln Gln Leu Ser Val Phe Lys Arg His Asn Pro
                 245                 250                 255    
 Ser Thr Ala Glu Glu Gln Glu Met Met Glu Asn Leu Phe Asp Ser Leu
             260                 265                 270        
 Cys Ser Cys Leu Met Leu Ser Ser Asn Arg Glu Arg Phe Leu Lys Gly
         275                 280                 285            
 Glu Gly Leu Gln Leu Met Asn Leu Met Leu Arg Glu Lys Lys Ile Ser
     290                 295                 300                
 Arg Ser Ser Ala Leu Lys Val Leu Asp His Ala Met Ile Gly Pro Glu
 305                 310                 315                 320
 Gly Thr Asp Asn Cys His Lys Phe Val Asp Ile Leu Gly Leu Arg Thr
                 325                 330                 335    
 Ile Phe Pro Leu Phe Met Lys Ser Pro Arg Lys Ile Lys Lys Val Gly
             340                 345                 350        
 Thr Thr Glu Lys Glu His Glu Glu His Val Cys Ser Ile Leu Ala Ser
         355                 360                 365            
 Leu Leu Arg Asn Leu Arg Gly Gln Gln Arg Thr Arg Leu Leu Asn Lys
     370                 375                 380                
 Phe Thr Glu Asn Asp Ser Glu Lys Val Asp Arg Leu Met Glu Leu His
 385                 390                 395                 400
 Phe Lys Tyr Leu Gly Ala Met Gln Val Ala Asp Lys Lys Ile Glu Gly
                 405                 410                 415    
 Glu Lys His Asp Met Val Arg Arg Gly Glu Ile Ile Asp Asn Asp Thr
             420                 425                 430        
 Glu Glu Glu Phe Tyr Leu Arg Arg Leu Asp Ala Gly Leu Phe Val Leu
         435                 440                 445            
 Gln His Ile Cys Tyr Ile Met Ala Glu Ile Cys Asn Ala Asn Val Pro
     450                 455                 460                
 Gln Ile Arg Gln Arg Val His Gln Ile Leu Asn Met Arg Gly Ser Ser
 465                 470                 475                 480
 Ile Lys Ile Val Arg His Ile Ile Lys Glu Tyr Ala Glu Asn Ile Gly
                 485                 490                 495    
 Asp Gly Arg Ser Pro Glu Phe Arg Glu Asn Glu Gln Lys Arg Ile Leu
             500                 505                 510        
 Gly Leu Leu Glu Asn Phe
         515            



      <210> 228
      <211> 418
      <212> PRT
      <213> Homo sapiens


      <400> 228
 Met Ser Leu Ser Asn Lys Leu Thr Leu Asp Lys Leu Asp Val Lys Gly
   1               5                  10                  15    
 Lys Arg Val Val Met Arg Val Asp Phe Asn Val Pro Met Lys Asn Asn
              20                  25                  30        
 Gln Ile Thr Asn Asn Gln Arg Ile Lys Ala Ala Val Pro Ser Ile Lys
          35                  40                  45            
 Phe Cys Leu Asp Asn Gly Ala Lys Ser Val Val Leu Met Ser His Leu
      50                  55                  60                
 Gly Arg Pro Asp Gly Val Pro Met Pro Asp Lys Tyr Ser Leu Glu Pro
  65                  70                  75                  80
 Val Ala Val Glu Leu Lys Ser Leu Leu Gly Lys Asp Val Leu Phe Leu
                  85                  90                  95    
 Lys Asp Cys Val Gly Pro Glu Val Glu Lys Ala Cys Ala Asn Pro Ala
             100                 105                 110        
 Ala Gly Ser Val Ile Leu Leu Glu Asn Leu Arg Phe His Val Glu Glu
         115                 120                 125            
 Glu Gly Lys Gly Lys Asp Ala Ser Gly Asn Lys Val Lys Ala Glu Pro
     130                 135                 140                
 Ala Lys Ile Glu Ala Phe Arg Ala Ser Leu Ser Lys Leu Gly Asp Val
 145                 150                 155                 160
 Tyr Val Asn Asp Ala Phe Gly Thr Ala His Arg Ala His Ser Ser Met
                 165                 170                 175    
 Val Gly Val Asn Leu Pro Gln Lys Ala Gly Gly Phe Leu Met Lys Lys
             180                 185                 190        
 Glu Leu Asn Tyr Phe Ala Lys Ala Leu Glu Ser Pro Glu Arg Pro Phe
         195                 200                 205            
 Leu Ala Ile Leu Gly Gly Ala Lys Val Ala Asp Lys Ile Gln Leu Ile
     210                 215                 220                
 Asn Asn Met Leu Asp Lys Val Asn Glu Met Ile Ile Gly Gly Gly Met
 225                 230                 235                 240
 Ala Phe Thr Phe Leu Lys Val Leu Asn Asn Met Glu Ile Gly Thr Ser
                 245                 250                 255    
 Leu Phe Asp Glu Glu Gly Ala Lys Ile Val Lys Asp Leu Met Ser Lys
             260                 265                 270        
 Ala Glu Lys Asn Gly Val Lys Ile Thr Leu Pro Val Asp Phe Val Thr
         275                 280                 285            
 Ala Asp Lys Phe Asp Glu Asn Ala Lys Thr Gly Gln Ala Thr Val Ala
     290                 295                 300                
 Ser Gly Ile Pro Ala Gly Trp Met Gly Leu Asp Cys Gly Pro Glu Ser
 305                 310                 315                 320
 Ser Lys Lys Tyr Ala Glu Ala Val Thr Arg Ala Lys Gln Ile Val Trp
                 325                 330                 335    
 Asn Gly Pro Val Gly Val Phe Glu Trp Glu Ala Phe Ala Arg Gly Thr
             340                 345                 350        
 Lys Ala Leu Met Asp Glu Val Val Lys Ala Thr Ser Arg Gly Cys Ile
         355                 360                 365            
 Thr Ile Ile Gly Gly Gly Asp Thr Ala Thr Cys Cys Ala Lys Trp Asn
     370                 375                 380                
 Thr Glu Asp Lys Val Ser His Val Ser Thr Gly Gly Gly Ala Ser Leu
 385                 390                 395                 400
 Glu Leu Leu Glu Gly Lys Val Leu Pro Gly Val Asp Ala Leu Ser Asn
                 405                 410                 415    
 Ile
    



      <210> 229
      <211> 365
      <212> PRT
      <213> Homo sapiens


      <400> 229
 Met Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe Ile
   1               5                  10                  15    
 Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile Asn His
              20                  25                  30        
 Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe Arg Gly
          35                  40                  45            
 Ser Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly Ser Ser
      50                  55                  60                
 Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val Val
  65                  70                  75                  80
 Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg Gly
                  85                  90                  95    
 Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg Glu
             100                 105                 110        
 Arg Ala Phe Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Gly Asn
         115                 120                 125            
 Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu Gly
     130                 135                 140                
 Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu Thr
 145                 150                 155                 160
 Gly Ser Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu Glu
                 165                 170                 175    
 Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr Glu
             180                 185                 190        
 Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser Leu
         195                 200                 205            
 Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu Gly
     210                 215                 220                
 Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala Trp
 225                 230                 235                 240
 Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe Arg
                 245                 250                 255    
 Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr Trp
             260                 265                 270        
 Thr Lys Tyr Tyr Asp Phe Lys Asn Pro Ile Ile Glu Lys Tyr Leu Arg
         275                 280                 285            
 Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro
     290                 295                 300                
 Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu Ala
 305                 310                 315                 320
 Gln Glu Ala Glu Ala Trp Leu Asn Tyr Pro Cys Phe Lys Asn Trp Asp
                 325                 330                 335    
 Gly Ser Pro Val Ser Ser Trp Ile Leu Leu Val Arg Pro Pro Ala Ser
             340                 345                 350        
 Ser Leu Pro Phe Ile Pro Ala Pro Leu His Glu Ala
         355                 360                



      <210> 230
      <211> 182
      <212> PRT
      <213> Homo sapiens


      <400> 230
 Met Gly Asn Ile Phe Ala Asn Leu Phe Lys Gly Leu Phe Gly Lys Lys
   1               5                  10                  15    
 Glu Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Thr Thr
              20                  25                  30        
 Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Thr Thr Ile Pro Thr
          35                  40                  45            
 Ile Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Ile Ser Phe Thr
      50                  55                  60                
 Val Trp Asp Val Gly Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His
  65                  70                  75                  80
 Tyr Phe Gln Asn Thr Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp
                  85                  90                  95    
 Arg Glu Arg Val Asn Glu Ala Arg Glu Glu Leu Met Arg Met Leu Ala
             100                 105                 110        
 Glu Asp Glu Leu Arg Asp Ala Val Leu Leu Val Phe Ala Asn Lys Gln
         115                 120                 125            
 Asp Leu Pro Asn Ala Met Asn Ala Ala Glu Ile Thr Asp Lys Leu Gly
     130                 135                 140                
 Leu His Ser Leu Arg His Arg Asn Trp Tyr Ile Gln Ala Thr Cys Ala
 145                 150                 155                 160
 Thr Ser Gly Asp Gly Leu Tyr Glu Gly Leu Asp Trp Leu Ser Asn Gln
                 165                 170                 175    
 Leu Arg Asn Gln Lys
             180    



      <210> 231
      <211> 341
      <212> PRT
      <213> Homo sapiens


      <400> 231
 Met Leu Arg Trp Thr Val His Leu Glu Gly Gly Pro Arg Arg Val Asn
   1               5                  10                  15    
 His Ala Ala Val Ala Val Gly His Arg Val Tyr Ser Phe Gly Gly Tyr
              20                  25                  30        
 Cys Ser Gly Glu Asp Tyr Glu Thr Leu Arg Gln Ile Asp Val His Ile
          35                  40                  45            
 Phe Asn Ala Val Ser Leu Arg Trp Thr Lys Leu Pro Pro Val Lys Ser
      50                  55                  60                
 Ala Ile Arg Gly Gln Ala Pro Val Val Pro Tyr Met Arg Tyr Gly His
  65                  70                  75                  80
 Ser Thr Val Leu Ile Asp Asp Thr Val Leu Leu Trp Gly Gly Arg Asn
                  85                  90                  95    
 Asp Thr Glu Gly Ala Cys Asn Val Leu Tyr Ala Phe Asp Val Asn Thr
             100                 105                 110        
 His Lys Trp Phe Thr Pro Arg Val Ser Gly Thr Val Pro Gly Ala Arg
         115                 120                 125            
 Asp Gly His Ser Ala Cys Val Leu Gly Lys Ile Met Tyr Ile Phe Gly
     130                 135                 140                
 Gly Tyr Glu Gln Gln Ala Asp Cys Phe Ser Asn Asp Ile His Lys Leu
 145                 150                 155                 160
 Asp Thr Ser Thr Met Thr Trp Thr Leu Ile Cys Thr Lys Gly Ser Pro
                 165                 170                 175    
 Ala Arg Trp Arg Asp Phe His Ser Ala Thr Met Leu Gly Ser His Met
             180                 185                 190        
 Tyr Val Phe Gly Gly Arg Ala Asp Arg Phe Gly Pro Phe His Ser Asn
         195                 200                 205            
 Asn Glu Ile Tyr Cys Asn Arg Ile Arg Val Phe Asp Thr Arg Thr Glu
     210                 215                 220                
 Ala Trp Leu Asp Cys Pro Pro Thr Pro Val Leu Pro Glu Gly Arg Arg
 225                 230                 235                 240
 Ser His Ser Ala Phe Gly Tyr Asn Gly Glu Leu Tyr Ile Phe Gly Gly
                 245                 250                 255    
 Tyr Asn Ala Arg Leu Asn Arg His Phe His Asp Leu Trp Lys Phe Asn
             260                 265                 270        
 Pro Val Ser Phe Thr Trp Lys Lys Ile Glu Pro Lys Gly Lys Gly Pro
         275                 280                 285            
 Cys Pro Arg Arg Arg Gln Cys Cys Cys Ile Val Gly Asp Lys Ile Val
     290                 295                 300                
 Leu Phe Gly Gly Thr Ser Pro Ser Pro Glu Glu Gly Leu Gly Asp Glu
 305                 310                 315                 320
 Phe Asp Leu Ile Asp His Ser Asp Leu His Ile Leu Asp Phe Ser Lys
                 325                 330                 335    
 Tyr Ser Tyr Ser
             340



      <210> 232
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 232
 Met Lys Val Ala Ser Gly Ser Thr Ala Thr Ala Ala Ala Gly Pro Ser
   1               5                  10                  15    
 Cys Ala Leu Lys Ala Gly Lys Thr Ala Ser Gly Ala Gly Glu Val Val
              20                  25                  30        
 Arg Cys Leu Ser Glu Gln Ser Val Ala Ile Ser Arg Cys Ala Gly Gly
          35                  40                  45            
 Ala Gly Ala Arg Leu Pro Ala Leu Leu Asp Glu Gln Gln Val Asn Val
      50                  55                  60                
 Leu Leu Tyr Asp Met Asn Gly Cys Tyr Ser Arg Leu Lys Glu Leu Val
  65                  70                  75                  80
 Pro Thr Leu Pro Gln Asn Arg Lys Val Ser Lys Val Glu Ile Leu Gln
                  85                  90                  95    
 His Val Ile Asp Tyr Ile Arg Asp Leu Gln Leu Glu Leu Asn Ser Glu
             100                 105                 110        
 Ser Glu Val Gly Thr Pro Gly Gly Arg Gly Leu Pro Val Arg Ala Pro
         115                 120                 125            
 Leu Ser Thr Leu Asn Gly Glu Ile Ser Ala Leu Thr Ala Glu Ala Ala
     130                 135                 140                
 Cys Val Pro Ala Asp Asp Arg Ile Leu Cys Arg
 145                 150                 155



      <210> 233
      <211> 339
      <212> PRT
      <213> Homo sapiens


      <400> 233
 Met Leu Ser Ala Leu Ala Arg Pro Val Ser Ala Ala Leu Arg Arg Ser
   1               5                  10                  15    
 Phe Ser Thr Ser Ala Gln Asn Asn Ala Lys Val Ala Val Leu Gly Ala
              20                  25                  30        
 Ser Gly Gly Ile Gly Gln Pro Leu Ser Leu Leu Leu Lys Asn Ser Pro
          35                  40                  45            
 Leu Val Ser Arg Leu Thr Leu Tyr Asp Ile Ala His Thr Pro Gly Val
      50                  55                  60                
 Ala Ala Asp Leu Ser His Ile Glu Thr Lys Ala Ala Val Lys Gly Tyr
  65                  70                  75                  80
 Leu Gly Pro Glu Gln Leu Pro Asp Cys Leu Lys Gly Cys Asp Val Val
                  85                  90                  95    
 Val Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met Thr Arg Asp Asp
             100                 105                 110        
 Leu Phe Asn Thr Asn Ala Thr Ile Val Ala Thr Leu Thr Ala Ala Cys
         115                 120                 125            
 Ala Gln His Cys Pro Glu Ala Met Ile Cys Val Ile Ala Asn Pro Val
     130                 135                 140                
 Asn Ser Thr Ile Pro Ile Thr Ala Glu Val Phe Lys Lys His Gly Val
 145                 150                 155                 160
 Tyr Asn Pro Asn Lys Ile Phe Gly Val Thr Thr Leu Asp Ile Val Arg
                 165                 170                 175    
 Ala Asn Thr Phe Val Ala Glu Leu Lys Gly Leu Asp Pro Ala Arg Val
             180                 185                 190        
 Asn Val Pro Val Ile Gly Gly His Ala Gly Lys Thr Ile Ile Pro Leu
         195                 200                 205            
 Ile Ser Gln Cys Thr Pro Lys Val Asp Phe Pro Gln Asp Gln Leu Thr
     210                 215                 220                
 Ala Leu Thr Gly Arg Ile Gln Glu Ala Gly Thr Glu Val Val Lys Ala
 225                 230                 235                 240
 Lys Ala Gly Ala Gly Ser Ala Thr Leu Ser Met Ala Tyr Ala Gly Ala
                 245                 250                 255    
 Arg Phe Val Phe Ser Leu Val Asp Ala Met Asn Gly Lys Glu Gly Val
             260                 265                 270        
 Val Glu Cys Ser Phe Val Lys Ser Gln Glu Thr Glu Cys Thr Tyr Phe
         275                 280                 285            
 Ser Thr Pro Leu Leu Leu Gly Lys Lys Gly Ile Glu Lys Asn Leu Gly
     290                 295                 300                
 Ile Gly Lys Val Ser Ser Phe Glu Glu Lys Met Ile Ser Asp Ala Ile
 305                 310                 315                 320
 Pro Glu Leu Lys Ala Ser Ile Lys Lys Gly Glu Asp Phe Val Lys Thr
                 325                 330                 335    
 Leu Lys
        



      <210> 234
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 234
 Met Asn Leu Ser Pro Val Ala Arg Leu Lys Lys Thr Trp Ser Lys Val
   1               5                  10                  15    
 Lys Thr Ala Lys Phe Asp Val Leu Glu His His Met Asp Pro Ser Ser
              20                  25                  30        
 Asn Phe Cys Asn Tyr Arg Thr Ala Leu Gln Gly Ala Thr Gln Arg Ser
          35                  40                  45            
 Gln Met Ala Asn Ser Ser Arg Glu Lys Ile Val Ile Pro Val Phe Asn
      50                  55                  60                
 Leu Phe Val Lys Asp Ile Tyr Phe Leu His Lys Ile His Thr Asn His
  65                  70                  75                  80
 Leu Pro Asn Gly His Ile Asn Phe Lys Lys Phe Trp Glu Ile Ser Arg
                  85                  90                  95    
 Gln Ile His Glu Phe Met Thr Trp Thr Gln Val Glu Cys Pro Phe Glu
             100                 105                 110        
 Lys Asp Lys Lys Ile Gln Ser Tyr Leu Leu Thr Ala Pro Ile Tyr Ser
         115                 120                 125            
 Glu Glu Ala Leu Phe Val Ala Ser Phe Glu Ser Glu Gly Pro Glu Asn
     130                 135                 140                
 His Met Glu Lys Asp Ser Trp Lys Thr Leu Arg Thr Thr Leu Leu Asn
 145                 150                 155                 160
 Arg Ala
        



      <210> 235
      <211> 1005
      <212> PRT
      <213> Homo sapiens


      <400> 235
 Met Leu Phe His Pro Leu Leu Pro His Leu Ile Ser Pro Pro Leu Asp
   1               5                  10                  15    
 Pro Gly Thr Leu Ala Gly Asn Gln Arg Leu Gln Gln Val Met His Ala
              20                  25                  30        
 Ala Asp Pro Leu Glu Ile Gln Ala Asp Val His Trp Thr His Ile Arg
          35                  40                  45            
 Glu Arg Glu Glu Glu Glu Arg Met Ala Pro Ala Ser Glu Ser Ser Ala
      50                  55                  60                
 Ser Gly Ala Pro Leu Asp Glu Asn Asp Leu Glu Glu Asp Val Asp Ser
  65                  70                  75                  80
 Glu Pro Ala Glu Ile Glu Gly Glu Ala Ala Glu Asp Gly Asp Pro Gly
                  85                  90                  95    
 Asp Thr Gly Ala Glu Leu Asp Asp Asp Gln His Trp Ser Asp Ser Pro
             100                 105                 110        
 Ser Asp Ala Asp Arg Glu Leu Arg Leu Pro Cys Pro Ala Glu Gly Glu
         115                 120                 125            
 Ala Glu Leu Glu Leu Arg Val Ser Glu Asp Glu Glu Lys Leu Pro Ala
     130                 135                 140                
 Ser Pro Lys His Gln Glu Arg Gly Pro Ser Gln Ala Thr Ser Pro Ile
 145                 150                 155                 160
 Arg Ser Pro Gln Glu Ser Ala Leu Leu Phe Ile Pro Val His Ser Pro
                 165                 170                 175    
 Ser Thr Glu Gly Pro Gln Leu Pro Pro Val Pro Ala Ala Thr Gln Glu
             180                 185                 190        
 Lys Ser Pro Glu Glu Arg Leu Phe Pro Glu Pro Leu Leu Pro Lys Glu
         195                 200                 205            
 Lys Pro Lys Ala Asp Ala Pro Ser Asp Leu Lys Ala Val His Ser Pro
     210                 215                 220                
 Ile Arg Ser Gln Pro Val Thr Leu Pro Glu Ala Arg Thr Pro Val Ser
 225                 230                 235                 240
 Pro Gly Ser Pro Gln Pro Gln Pro Pro Val Ala Ala Ser Thr Pro Pro
                 245                 250                 255    
 Pro Ser Pro Leu Pro Ile Cys Ser Gln Pro Gln Pro Ser Thr Glu Ala
             260                 265                 270        
 Thr Val Pro Ser Pro Thr Gln Ser Pro Ile Arg Phe Gln Pro Ala Pro
         275                 280                 285            
 Ala Lys Thr Ser Thr Pro Leu Ala Pro Leu Pro Val Gln Ser Gln Ser
     290                 295                 300                
 Asp Thr Lys Asp Arg Leu Gly Ser Pro Leu Ala Val Asp Glu Ala Leu
 305                 310                 315                 320
 Arg Arg Ser Asp Leu Val Glu Glu Phe Trp Met Lys Ser Ala Glu Ile
                 325                 330                 335    
 Arg Arg Ser Leu Gly Leu Thr Pro Val Asp Arg Ser Lys Gly Pro Glu
             340                 345                 350        
 Pro Ser Phe Pro Thr Pro Ala Phe Arg Pro Val Ser Leu Lys Ser Tyr
         355                 360                 365            
 Ser Val Glu Lys Ser Pro Gln Asp Glu Gly Leu His Leu Leu Lys Pro
     370                 375                 380                
 Leu Ser Ile Pro Lys Arg Leu Gly Leu Pro Lys Pro Glu Gly Glu Pro
 385                 390                 395                 400
 Leu Ser Leu Pro Thr Pro Arg Ser Pro Ser Asp Arg Glu Leu Arg Ser
                 405                 410                 415    
 Ala Gln Glu Glu Arg Arg Glu Leu Ser Ser Ser Ser Gly Leu Gly Leu
             420                 425                 430        
 His Gly Ser Ser Ser Asn Met Lys Thr Leu Gly Ser Gln Ser Phe Asn
         435                 440                 445            
 Thr Ser Asp Ser Ala Met Leu Thr Pro Pro Ser Ser Pro Pro Pro Pro
     450                 455                 460                
 Pro Pro Pro Gly Glu Glu Pro Ala Thr Leu Arg Arg Lys Leu Arg Glu
 465                 470                 475                 480
 Ala Glu Pro Asn Ala Ser Val Val Pro Pro Pro Leu Pro Ala Thr Trp
                 485                 490                 495    
 Met Arg Pro Pro Arg Glu Pro Ala Gln Pro Pro Arg Glu Glu Val Arg
             500                 505                 510        
 Lys Ser Phe Val Glu Ser Val Glu Glu Ile Pro Phe Ala Asp Asp Val
         515                 520                 525            
 Glu Asp Thr Tyr Asp Asp Lys Thr Glu Asp Ser Ser Leu Gln Glu Lys
     530                 535                 540                
 Phe Phe Thr Pro Pro Ser Cys Trp Pro Arg Pro Glu Lys Pro Arg His
 545                 550                 555                 560
 Pro Pro Leu Ala Lys Glu Asn Gly Arg Leu Pro Ala Leu Glu Gly Thr
                 565                 570                 575    
 Leu Gln Pro Gln Lys Arg Gly Leu Pro Leu Val Ser Ala Glu Ala Lys
             580                 585                 590        
 Glu Leu Ala Glu Glu Arg Met Arg Ala Arg Glu Lys Ser Val Lys Ser
         595                 600                 605            
 Gln Ala Leu Arg Asp Ala Met Ala Arg Gln Leu Ser Arg Met Gln Gln
     610                 615                 620                
 Met Glu Leu Ala Ser Gly Ala Pro Arg Pro Arg Lys Ala Ser Ser Ala
 625                 630                 635                 640
 Pro Ser Gln Gly Lys Glu Arg Arg Pro Asp Ser Pro Thr Arg Pro Thr
                 645                 650                 655    
 Leu Arg Gly Ser Glu Glu Pro Thr Leu Lys His Glu Ala Thr Ser Glu
             660                 665                 670        
 Glu Val Leu Ser Pro Pro Ser Asp Ser Gly Gly Pro Asp Gly Ser Phe
         675                 680                 685            
 Thr Ser Ser Glu Gly Ser Ser Gly Lys Ser Lys Lys Arg Ser Ser Leu
     690                 695                 700                
 Phe Ser Pro Arg Arg Asn Lys Lys Glu Lys Lys Ser Lys Gly Glu Gly
 705                 710                 715                 720
 Arg Pro Pro Glu Lys Pro Ser Ser Asn Leu Leu Glu Glu Ala Ala Ala
                 725                 730                 735    
 Lys Pro Lys Ser Leu Trp Lys Ser Val Phe Ser Gly Tyr Lys Lys Asp
             740                 745                 750        
 Lys Lys Lys Lys Ala Asp Asp Lys Ser Cys Pro Ser Thr Pro Ser Ser
         755                 760                 765            
 Gly Ala Thr Val Asp Ser Gly Lys His Arg Val Leu Pro Val Val Arg
     770                 775                 780                
 Ala Glu Leu Gln Leu Arg Arg Gln Leu Ser Phe Ser Glu Asp Ser Asp
 785                 790                 795                 800
 Leu Ser Ser Asp Asp Val Leu Glu Lys Ser Ser Gln Lys Ser Arg Arg
                 805                 810                 815    
 Glu Pro Arg Thr Tyr Thr Glu Glu Glu Leu Asn Ala Lys Leu Thr Arg
             820                 825                 830        
 Arg Val Gln Lys Ala Ala Arg Arg Gln Ala Lys Gln Glu Glu Leu Lys
         835                 840                 845            
 Arg Leu His Arg Ala Gln Ile Ile Gln Arg Gln Leu Gln Gln Val Glu
     850                 855                 860                
 Glu Arg Gln Arg Arg Leu Glu Glu Arg Gly Val Ala Val Glu Lys Ala
 865                 870                 875                 880
 Leu Arg Gly Glu Ala Gly Met Gly Lys Lys Asp Asp Pro Lys Leu Met
                 885                 890                 895    
 Gln Glu Trp Phe Lys Leu Val Gln Glu Lys Asn Ala Met Val Arg Tyr
             900                 905                 910        
 Glu Ser Glu Leu Met Ile Phe Ala Arg Glu Leu Glu Leu Glu Asp Arg
         915                 920                 925            
 Gln Ser Arg Leu Gln Gln Glu Leu Arg Glu Arg Met Ala Val Glu Asp
     930                 935                 940                
 His Leu Lys Thr Glu Glu Glu Leu Ser Glu Glu Lys Gln Ile Leu Asn
 945                 950                 955                 960
 Glu Met Leu Glu Val Val Glu Gln Arg Asp Ser Leu Val Ala Leu Leu
                 965                 970                 975    
 Glu Glu Gln Arg Leu Arg Glu Arg Glu Glu Asp Lys Asp Leu Glu Ala
             980                 985                 990        
 Ala Met Leu Ser Lys Gly Phe Ser Leu Asn Trp Ser
         995                1000                



      <210> 236
      <211> 115
      <212> PRT
      <213> Homo sapiens


      <400> 236
 Met Asn Val Leu Leu Gly Ser Val Val Ile Phe Ala Thr Phe Val Thr
   1               5                  10                  15    
 Leu Cys Asn Ala Ser Cys Tyr Phe Ile Pro Asn Glu Gly Val Pro Gly
              20                  25                  30        
 Asp Ser Thr Arg Lys Cys Met Asp Leu Lys Gly Asn Lys His Pro Ile
          35                  40                  45            
 Asn Ser Glu Trp Gln Thr Asp Asn Cys Glu Thr Cys Thr Cys Tyr Glu
      50                  55                  60                
 Thr Glu Ile Ser Cys Cys Thr Leu Val Ser Thr Pro Val Gly Tyr Asp
  65                  70                  75                  80
 Lys Asp Asn Cys Gln Arg Ile Phe Lys Lys Glu Asp Cys Lys Tyr Ile
                  85                  90                  95    
 Val Val Glu Lys Lys Asp Pro Lys Lys Thr Cys Ser Val Ser Glu Trp
             100                 105                 110        
 Ile Ile
        



      <210> 237
      <211> 144
      <212> PRT
      <213> Homo sapiens


      <400> 237
 Met Gln His Arg Gly Phe Leu Leu Leu Thr Leu Leu Ala Leu Leu Ala
   1               5                  10                  15    
 Leu Thr Ser Ala Val Ala Lys Lys Lys Asp Lys Val Lys Lys Gly Gly
              20                  25                  30        
 Pro Gly Ser Glu Cys Ala Glu Trp Ala Trp Gly Pro Cys Thr Pro Ser
          35                  40                  45            
 Ser Lys Asp Cys Gly Val Gly Phe Arg Glu Gly Thr Cys Gly Ala Gln
      50                  55                  60                
 Thr Gln Arg Ile Arg Cys Arg Val Pro Cys Asn Trp Lys Lys Glu Phe
  65                  70                  75                  80
 Gly Ala Asp Cys Lys Tyr Lys Phe Glu Asn Trp Gly Ala Cys Asp Gly
                  85                  90                  95    
 Gly Thr Gly Thr Lys Val Arg Gln Gly Thr Leu Lys Lys Ala Arg Tyr
             100                 105                 110        
 Asn Ala Gln Cys Gln Glu Thr Ile Arg Val Thr Lys Pro Cys Thr Pro
         115                 120                 125            
 Lys Thr Lys Ala Lys Ala Lys Ala Lys Lys Gly Lys Gly Lys Asp
     130                 135                 140            



      <210> 238
      <211> 485
      <212> PRT
      <213> Homo sapiens


      <400> 238
 Met Asn Val Thr Pro Glu Val Lys Ser Arg Gly Met Lys Phe Ala Glu
   1               5                  10                  15    
 Glu Gln Leu Leu Lys His Gly Trp Thr Gln Gly Lys Gly Leu Gly Arg
              20                  25                  30        
 Lys Glu Asn Gly Ile Thr Gln Ala Leu Arg Val Thr Leu Lys Gln Asp
          35                  40                  45            
 Thr His Gly Val Gly His Asp Pro Ala Lys Glu Phe Thr Asn His Trp
      50                  55                  60                
 Trp Asn Glu Leu Phe Asn Lys Thr Ala Ala Asn Leu Val Val Glu Thr
  65                  70                  75                  80
 Gly Gln Asp Gly Val Gln Ile Arg Ser Leu Ser Lys Glu Thr Thr Arg
                  85                  90                  95    
 Tyr Asn His Pro Lys Pro Asn Leu Leu Tyr Gln Lys Phe Val Lys Met
             100                 105                 110        
 Ala Thr Leu Thr Ser Gly Gly Glu Lys Pro Asn Lys Asp Leu Glu Ser
         115                 120                 125            
 Cys Ser Asp Asp Asp Asn Gln Gly Ser Lys Ser Pro Lys Ile Leu Thr
     130                 135                 140                
 Asp Glu Met Leu Leu Gln Ala Cys Glu Gly Arg Thr Ala His Lys Ala
 145                 150                 155                 160
 Ala Arg Leu Gly Ile Thr Met Lys Ala Lys Leu Ala Arg Leu Glu Ala
                 165                 170                 175    
 Gln Glu Gln Ala Phe Leu Ala Arg Leu Lys Gly Gln Asp Pro Gly Ala
             180                 185                 190        
 Pro Gln Leu Gln Ser Glu Ser Lys Pro Pro Lys Lys Lys Lys Lys Lys
         195                 200                 205            
 Arg Arg Gln Lys Glu Glu Glu Glu Ala Thr Ala Ser Glu Arg Asn Asp
     210                 215                 220                
 Ala Asp Glu Lys His Pro Glu His Ala Glu Gln Asn Ile Arg Lys Ser
 225                 230                 235                 240
 Lys Lys Lys Lys Lys Lys Arg Arg Gln Lys Glu Glu Glu Glu Ala Thr
                 245                 250                 255    
 Ala Ser Glu Arg Asn Asp Ala Asp Glu Lys His Pro Glu His Ala Glu
             260                 265                 270        
 Gln Asn Ile Arg Lys Ser Lys Lys Lys Lys Arg Arg His Gln Glu Gly
         275                 280                 285            
 Lys Val Ser Asp Glu Arg Glu Gly Thr Thr Lys Gly Asn Glu Lys Glu
     290                 295                 300                
 Asp Ala Ala Gly Thr Ser Gly Leu Gly Glu Leu Asn Ser Arg Glu Gln
 305                 310                 315                 320
 Thr Asn Gln Ser Leu Arg Lys Gly Lys Lys Lys Lys Arg Trp His His
                 325                 330                 335    
 Glu Glu Glu Lys Met Gly Val Leu Glu Glu Gly Gly Lys Gly Lys Glu
             340                 345                 350        
 Ala Ala Gly Ser Val Arg Thr Glu Glu Val Glu Ser Arg Ala Tyr Ala
         355                 360                 365            
 Asp Pro Cys Ser Arg Arg Lys Lys Arg Gln Gln Gln Glu Glu Glu Asp
     370                 375                 380                
 Leu Asn Leu Glu Asp Arg Gly Glu Glu Thr Val Leu Gly Gly Gly Thr
 385                 390                 395                 400
 Arg Glu Ala Glu Ser Arg Ala Cys Ser Asp Gly Arg Ser Arg Lys Ser
                 405                 410                 415    
 Lys Lys Lys Arg Gln Gln His Gln Glu Glu Glu Asp Ile Leu Asp Val
             420                 425                 430        
 Arg Asp Glu Lys Asp Ser Gly Ala Arg Glu Ala Glu Ser Arg Ala His
         435                 440                 445            
 Thr Gly Ser Ser Ser Arg Gly Lys Arg Lys Arg Gln Gln His Pro Lys
     450                 455                 460                
 Lys Glu Arg Ala Gly Val Ser Thr Val Gln Lys Ala Lys Lys Lys Gln
 465                 470                 475                 480
 Lys Lys Arg Asp
                



      <210> 239
      <211> 330
      <212> PRT
      <213> Homo sapiens


      <400> 239
 Met Gly Ala Thr Gly Asp Ala Glu Gln Pro Arg Gly Pro Ser Gly Ala
   1               5                  10                  15    
 Glu Arg Gly Gly Leu Glu Leu Gly Asp Ala Gly Ala Ala Gly Gln Leu
              20                  25                  30        
 Val Leu Thr Asn Pro Trp Asn Ile Met Ile Lys His Arg Gln Val Gln
          35                  40                  45            
 Arg Arg Gly Arg Arg Ser Gln Met Thr Thr Ser Phe Thr Asp Pro Ala
      50                  55                  60                
 Ile Ser Met Asp Leu Leu Arg Ala Val Leu Gln Pro Ser Ile Asn Glu
  65                  70                  75                  80
 Glu Ile Gln Thr Val Phe Asn Lys Tyr Met Lys Phe Phe Gln Lys Ala
                  85                  90                  95    
 Ala Leu Asn Val Arg Asp Asn Val Gly Glu Glu Val Asp Ala Glu Gln
             100                 105                 110        
 Leu Ile Gln Glu Ala Cys Arg Ser Cys Leu Glu Gln Ala Lys Leu Leu
         115                 120                 125            
 Phe Ser Asp Gly Glu Lys Val Ile Pro Arg Leu Thr His Glu Leu Pro
     130                 135                 140                
 Gly Ile Lys Arg Gly Arg Gln Ala Glu Glu Glu Cys Ala His Arg Gly
 145                 150                 155                 160
 Ser Pro Leu Pro Lys Lys Arg Lys Gly Arg Pro Pro Gly His Ile Leu
                 165                 170                 175    
 Ser Ser Asp Arg Ala Ala Ala Gly Met Val Trp Lys Pro Lys Ser Cys
             180                 185                 190        
 Glu Pro Ile Arg Arg Glu Gly Pro Lys Trp Asp Pro Ala Arg Leu Asn
         195                 200                 205            
 Glu Ser Thr Thr Phe Val Leu Gly Ser Arg Ala Asn Lys Ala Leu Gly
     210                 215                 220                
 Met Gly Gly Thr Arg Gly Arg Ile Tyr Ile Lys His Pro His Leu Phe
 225                 230                 235                 240
 Lys Tyr Ala Ala Asp Pro Gln Asp Lys His Trp Leu Ala Glu Gln His
                 245                 250                 255    
 His Met Arg Ala Thr Gly Gly Lys Met Ala Tyr Leu Leu Ile Glu Glu
             260                 265                 270        
 Asp Ile Arg Asp Leu Ala Ala Ser Asp Asp Tyr Arg Gly Cys Leu Asp
         275                 280                 285            
 Leu Lys Leu Glu Glu Leu Lys Ser Phe Val Leu Pro Ser Trp Met Val
     290                 295                 300                
 Glu Lys Met Arg Lys Tyr Met Glu Thr Leu Arg Thr Glu Asn Glu His
 305                 310                 315                 320
 Arg Ala Val Glu Ala Pro Pro Gln Thr
                 325                



      <210> 240
      <211> 759
      <212> PRT
      <213> Homo sapiens


      <400> 240
 Met Arg Leu Ala Cys Arg Leu Asp Pro Lys Thr Ser Phe Gln Met Ala
   1               5                  10                  15    
 Gly Glu Trp Leu Lys Tyr Gln Leu Ser Thr Phe Leu Asp Ala Gly Ser
              20                  25                  30        
 Val Asn Ser Cys Ser Ala Val Gly Thr Gly Glu Gly Ser Leu Cys Ser
          35                  40                  45            
 Val Phe Ser Pro Ser Phe Val Gln Trp Glu Ala Met Thr Leu Phe Leu
      50                  55                  60                
 Glu Ser Val Ile Thr Gln Met Phe Arg Thr Leu Asn Arg Glu Glu Ile
  65                  70                  75                  80
 Pro Val Asn Asp Gly Ile Glu Leu Leu Gln Met Val Leu Asn Phe Asp
                  85                  90                  95    
 Thr Lys Asp Pro Leu Ile Leu Ser Cys Val Leu Thr Asn Val Ser Ala
             100                 105                 110        
 Leu Phe Pro Phe Val Thr Tyr Arg Pro Glu Phe Leu Pro Gln Val Phe
         115                 120                 125            
 Ser Lys Leu Phe Ser Ser Val Thr Phe Glu Thr Val Glu Glu Ser Lys
     130                 135                 140                
 Ala Pro Arg Thr Arg Ala Val Arg Asn Val Arg Arg His Ala Cys Ser
 145                 150                 155                 160
 Ser Ile Ile Lys Met Cys Arg Asp Tyr Pro Gln Leu Val Leu Pro Asn
                 165                 170                 175    
 Phe Asp Met Leu Tyr Asn His Val Lys Gln Leu Leu Ser Asn Glu Leu
             180                 185                 190        
 Leu Leu Thr Gln Met Glu Lys Cys Ala Leu Met Glu Ala Leu Val Leu
         195                 200                 205            
 Ile Ser Asn Gln Phe Lys Asn Tyr Glu Arg Gln Lys Val Phe Leu Glu
     210                 215                 220                
 Glu Leu Met Ala Pro Val Ala Ser Ile Trp Leu Ser Gln Asp Met His
 225                 230                 235                 240
 Arg Val Leu Ser Asp Val Asp Ala Phe Ile Ala Tyr Val Gly Thr Asp
                 245                 250                 255    
 Gln Lys Ser Cys Asp Pro Gly Leu Glu Asp Pro Cys Gly Leu Asn Arg
             260                 265                 270        
 Ala Arg Met Ser Phe Cys Val Tyr Ser Ile Leu Gly Val Val Lys Arg
         275                 280                 285            
 Thr Cys Trp Pro Thr Asp Leu Glu Glu Ala Lys Ala Gly Gly Phe Val
     290                 295                 300                
 Val Gly Tyr Thr Ser Ser Gly Asn Pro Ile Phe Arg Asn Pro Cys Thr
 305                 310                 315                 320
 Glu Gln Ile Leu Lys Leu Leu Asp Asn Leu Leu Ala Leu Ile Arg Thr
                 325                 330                 335    
 His Asn Thr Leu Tyr Ala Pro Glu Met Leu Ala Lys Met Ala Glu Pro
             340                 345                 350        
 Phe Thr Lys Ala Leu Asp Met Leu Asp Ala Glu Lys Ser Ala Ile Leu
         355                 360                 365            
 Gly Leu Pro Gln Pro Leu Leu Glu Leu Asn Asp Ser Pro Val Phe Lys
     370                 375                 380                
 Thr Val Leu Glu Arg Met Gln Arg Phe Phe Ser Thr Leu Tyr Glu Asn
 385                 390                 395                 400
 Cys Phe His Ile Leu Gly Lys Ala Gly Pro Ser Met Gln Gln Asp Phe
                 405                 410                 415    
 Tyr Thr Val Glu Asp Leu Ala Thr Gln Leu Leu Ser Ser Ala Phe Val
             420                 425                 430        
 Asn Leu Asn Asn Ile Pro Asp Tyr Arg Leu Arg Pro Met Leu Arg Val
         435                 440                 445            
 Phe Val Lys Pro Leu Val Leu Phe Cys Pro Pro Glu His Tyr Glu Ala
     450                 455                 460                
 Leu Val Ser Pro Ile Leu Gly Pro Leu Phe Thr Tyr Leu His Met Arg
 465                 470                 475                 480
 Leu Ser Gln Lys Trp Gln Val Ile Asn Gln Arg Ser Leu Leu Cys Gly
                 485                 490                 495    
 Glu Asp Glu Ala Ala Asp Glu Asn Pro Glu Ser Gln Glu Met Leu Glu
             500                 505                 510        
 Glu Gln Leu Val Arg Met Leu Thr Arg Glu Val Met Asp Leu Ile Thr
         515                 520                 525            
 Val Cys Cys Val Ser Lys Lys Gly Ala Asp His Ser Ser Ala Pro Pro
     530                 535                 540                
 Ala Asp Gly Asp Asp Glu Glu Met Met Ala Thr Glu Val Thr Pro Ser
 545                 550                 555                 560
 Ala Met Ala Glu Leu Thr Asp Leu Gly Lys Cys Leu Met Lys His Glu
                 565                 570                 575    
 Asp Val Cys Thr Ala Leu Leu Ile Thr Ala Phe Asn Ser Leu Ala Trp
             580                 585                 590        
 Lys Asp Thr Leu Ser Cys Gln Arg Thr Thr Ser Gln Leu Cys Trp Pro
         595                 600                 605            
 Leu Leu Lys Gln Val Leu Ser Gly Thr Leu Leu Ala Asp Ala Val Thr
     610                 615                 620                
 Trp Leu Phe Thr Ser Val Leu Lys Gly Leu Gln Met His Gly Gln His
 625                 630                 635                 640
 Asp Gly Cys Met Ala Ser Leu Val His Leu Ala Phe Gln Ile Tyr Glu
                 645                 650                 655    
 Ala Leu Arg Pro Arg Tyr Leu Glu Ile Arg Ala Val Met Glu Gln Ile
             660                 665                 670        
 Pro Glu Ile Gln Lys Asp Ser Leu Asp Gln Phe Asp Cys Lys Leu Leu
         675                 680                 685            
 Asn Pro Ser Leu Gln Lys Val Ala Asp Lys Arg Arg Lys Asp Gln Phe
     690                 695                 700                
 Lys Arg Leu Ile Ala Gly Cys Ile Gly Lys Pro Leu Gly Glu Gln Phe
 705                 710                 715                 720
 Arg Lys Glu Val His Ile Lys Asn Leu Pro Ser Leu Phe Lys Lys Thr
                 725                 730                 735    
 Lys Pro Met Leu Glu Thr Glu Val Leu Asp Asn Asp Gly Gly Gly Leu
             740                 745                 750        
 Ala Thr Ile Phe Glu Pro
         755            



      <210> 241
      <211> 1135
      <212> PRT
      <213> Homo sapiens


      <400> 241
 Met Ser Glu Pro His Arg Val Gln Phe Thr Ser Leu Pro Gly Ser Leu
   1               5                  10                  15    
 Asn Pro Ala Phe Leu Lys Lys Ser Arg Lys Glu Glu Ala Gly Ala Gly
              20                  25                  30        
 Glu Gln His Gln Asp Cys Glu Pro Ala Ala Ala Ala Val Arg Ile Thr
          35                  40                  45            
 Leu Thr Leu Phe Glu Pro Asp His Lys Arg Cys Pro Glu Phe Phe Tyr
      50                  55                  60                
 Pro Glu Leu Val Lys Asn Ile Arg Gly Lys Val Lys Gly Leu Gln Pro
  65                  70                  75                  80
 Gly Asp Lys Lys Lys Asp Leu Ser Asp Pro Phe Asn Asp Glu Glu Lys
                  85                  90                  95    
 Glu Arg His Lys Val Glu Ala Leu Ala Arg Lys Phe Glu Glu Lys Tyr
             100                 105                 110        
 Gly Gly Lys Lys Arg Arg Lys Asp Arg Ile Gln Asp Leu Ile Asp Met
         115                 120                 125            
 Gly Tyr Gly Tyr Asp Glu Ser Asp Ser Phe Ile Asp Asn Ser Glu Ala
     130                 135                 140                
 Tyr Asp Glu Leu Val Pro Ala Ser Leu Thr Thr Lys Tyr Gly Gly Phe
 145                 150                 155                 160
 Tyr Ile Asn Ser Gly Thr Leu Gln Phe Arg Gln Ala Ser Glu Ser Glu
                 165                 170                 175    
 Asp Asp Phe Ile Lys Glu Lys Lys Lys Lys Ser Pro Lys Lys Arg Lys
             180                 185                 190        
 Leu Lys Glu Gly Gly Glu Lys Ile Lys Lys Lys Lys Lys Asp Asp Thr
         195                 200                 205            
 Tyr Asp Lys Glu Lys Lys Ser Lys Lys Ser Lys Phe Ser Lys Ala Gly
     210                 215                 220                
 Phe Thr Ala Leu Asn Ala Ser Lys Glu Lys Lys Lys Lys Lys Tyr Ser
 225                 230                 235                 240
 Gly Ala Leu Ser Val Lys Glu Met Leu Lys Lys Phe Gln Lys Glu Lys
                 245                 250                 255    
 Glu Ala Gln Lys Lys Arg Glu Glu Glu His Lys Pro Val Ala Val Pro
             260                 265                 270        
 Ser Ala Glu Ala Gln Gly Leu Arg Glu Leu Glu Gly Ala Ser Asp Pro
         275                 280                 285            
 Leu Leu Ser Leu Phe Gly Ser Thr Ser Asp Asn Asp Leu Leu Gln Ala
     290                 295                 300                
 Ala Thr Ala Met Asp Ser Leu Thr Asp Leu Asp Leu Glu His Leu Leu
 305                 310                 315                 320
 Ser Glu Ser Pro Glu Gly Ser Pro Phe Arg Asp Met Asp Asp Gly Ser
                 325                 330                 335    
 Asp Ser Leu Gly Val Gly Leu Asp Gln Glu Phe Arg Gln Pro Ser Ser
             340                 345                 350        
 Leu Pro Glu Gly Leu Pro Ala Pro Leu Glu Lys Arg Val Lys Glu Leu
         355                 360                 365            
 Ala Gln Ala Ala Arg Ala Ala Glu Gly Glu Ser Arg Gln Lys Phe Phe
     370                 375                 380                
 Thr Gln Asp Ile Asn Gly Ile Leu Leu Asp Ile Glu Ala Gln Thr Arg
 385                 390                 395                 400
 Glu Leu Ser Ser Gln Val Arg Ser Gly Val Tyr Ala Tyr Leu Ala Ser
                 405                 410                 415    
 Phe Leu Pro Cys Ser Lys Asp Ala Leu Leu Lys Arg Ala Arg Lys Leu
             420                 425                 430        
 His Leu Tyr Glu Gln Gly Gly Arg Leu Lys Glu Pro Leu Gln Lys Leu
         435                 440                 445            
 Lys Glu Ala Ile Gly Arg Ala Met Pro Glu Gln Met Ala Lys Tyr Gln
     450                 455                 460                
 Asp Glu Cys Gln Ala His Thr Gln Ala Lys Val Ala Lys Met Leu Glu
 465                 470                 475                 480
 Glu Glu Lys Asp Lys Glu Gln Arg Asp Arg Ile Cys Ser Asp Glu Glu
                 485                 490                 495    
 Glu Asp Glu Glu Lys Gly Gly Arg Arg Ile Met Gly Pro Arg Lys Lys
             500                 505                 510        
 Phe Gln Trp Asn Asp Glu Ile Arg Glu Leu Leu Cys Gln Val Val Lys
         515                 520                 525            
 Ile Lys Leu Glu Ser Gln Asp Leu Glu Arg Asn Asn Lys Ala Gln Ala
     530                 535                 540                
 Trp Glu Asp Cys Val Lys Gly Phe Leu Asp Ala Glu Val Lys Pro Leu
 545                 550                 555                 560
 Trp Pro Lys Gly Trp Met Gln Ala Arg Thr Leu Phe Lys Glu Ser Arg
                 565                 570                 575    
 Arg Gly His Gly His Leu Thr Ser Ile Leu Ala Lys Lys Lys Val Met
             580                 585                 590        
 Ala Pro Ser Lys Ile Lys Val Lys Glu Ser Ser Thr Lys Pro Asp Lys
         595                 600                 605            
 Lys Val Ser Val Pro Ser Gly Gln Ile Gly Gly Pro Ile Ala Leu Pro
     610                 615                 620                
 Ser Asp His Gln Thr Gly Gly Leu Ser Ile Gly Ala Ser Ser Arg Glu
 625                 630                 635                 640
 Leu Pro Ser Gln Ala Ser Gly Gly Leu Ala Asn Pro Pro Pro Val Asn
                 645                 650                 655    
 Leu Glu Asp Ser Leu Asp Glu Asp Leu Ile Arg Asn Pro Ala Ser Ser
             660                 665                 670        
 Val Glu Ala Val Ser Lys Glu Leu Ala Ala Leu Asn Ser Arg Ala Ala
         675                 680                 685            
 Gly Asn Ser Glu Phe Thr Leu Pro Ala Pro Ser Lys Ala Pro Ala Glu
     690                 695                 700                
 Lys Val Gly Gly Val Leu Cys Thr Glu Glu Lys Arg Asn Phe Ala Lys
 705                 710                 715                 720
 Pro Ser Pro Ser Ala Pro Pro Pro Ala Ser Ser Leu Gln Ser Pro Leu
                 725                 730                 735    
 Asn Phe Leu Ala Glu Gln Ala Leu Ala Leu Gly Gln Ser Ser Gln Glu
             740                 745                 750        
 Lys Lys Pro Glu Ser Ser Gly Tyr Lys Glu Leu Ser Cys Gln Ala Pro
         755                 760                 765            
 Leu Asn Lys Gly Leu Pro Glu Val His Gln Ser Lys Ala Lys His His
     770                 775                 780                
 Ser Leu Pro Arg Thr Ser His Gly Pro Gln Val Ala Val Pro Val Pro
 785                 790                 795                 800
 Gly Pro Gln Val Lys Val Phe His Ala Gly Thr Gln Gln Gln Lys Asn
                 805                 810                 815    
 Phe Thr Pro Pro Ser Pro Phe Ala Asn Lys Leu Gln Gly Pro Lys Ala
             820                 825                 830        
 Ser Pro Thr Gln Cys His Arg Ser Leu Leu Gln Leu Val Lys Thr Ala
         835                 840                 845            
 Ala Lys Gly Gln Gly Phe His Pro Ser Ala Pro Ala Thr Ser Gly Gly
     850                 855                 860                
 Leu Ser Ala Ser Ser Ser Ser Ser His Lys Thr Pro Ala Ser Ser Ser
 865                 870                 875                 880
 Ser Ala Leu Ser His Pro Ala Lys Pro His Ser Val Ser Ser Ala Gly
                 885                 890                 895    
 Ser Ser Tyr Lys Asn Asn Pro Phe Ala Ser Ser Ile Ser Lys His Gly
             900                 905                 910        
 Val Ser Ser Gly Ser Ser Ser Ser Gly Gly Thr Pro Val Gln Ser Ser
         915                 920                 925            
 Val Ser Gly Ser Leu Val Pro Gly Ile Gln Pro Pro Ser Val Gly Gln
     930                 935                 940                
 Ala Thr Ser Arg Pro Val Pro Ser Ser Ala Gly Lys Lys Met Pro Val
 945                 950                 955                 960
 Ser Gln Lys Leu Thr Leu Val Ala Pro Pro Gly Gly Pro Asn Gly Asp
                 965                 970                 975    
 Ser Ser Gly Gly Thr Gln Gly Val Ala Lys Leu Leu Thr Ser Pro Ser
             980                 985                 990        
 Leu Lys Pro Ser Ala Val Ser Ser Val Thr Ser Ser Thr Ser Leu Ser
         995                1000                1005            
 Lys Gly Ala Ser Gly Thr Val Leu Leu Ala Gly Ser Ser Leu Met Ala
    1010                1015                1020                
 Ser Pro Tyr Lys Ser Ser Ser Pro Lys Leu Ser Gly Ala Met Ser Ser
1025                1030                1035                1040
 Asn Ser Leu Gly Ile Ile Thr Pro Val Pro Ile Pro Val His Val Leu
                1045                1050                1055    
 Ser Phe Ser Ala Asp Ser Ser Ala Lys Ala Gly Val Ser Lys Asp Ala
            1060                1065                1070        
 Ile Val Thr Gly Pro Ala Pro Gly Ser Phe His His Gly Leu Gly His
        1075                1080                1085            
 Ser Leu Leu Ala Gly Leu His Ser Ser Pro Pro His Ala Ala Pro Leu
    1090                1095                1100                
 Pro His Ala Ala Val Pro Thr His Ile Pro Gln Ser Leu Pro Gly Ala
1105                1110                1115                1120
 Ser Gln Leu His Gly Lys Gly Pro Ala Val Pro Arg Lys Leu
                1125                1130                



      <210> 242
      <211> 72
      <212> PRT
      <213> Homo sapiens


      <400> 242
 Met Thr Pro Cys Leu Ala Asn Leu Phe Phe Phe Lys Leu Glu Gly Gly
   1               5                  10                  15    
 Phe Cys His Val Ala Gln Thr Ser Leu Lys Leu Leu Gly Ser Ser Ser
              20                  25                  30        
 Pro Phe Ile Leu Ala Ser Arg Ser Thr Gly Ile Thr Gly Met Asn His
          35                  40                  45            
 His Ala Gln Pro Thr Ser Lys Leu Ile Asn Met Gly Val Ala Phe Asn
      50                  55                  60                
 His Pro Gln Val Asn Ser Leu
  65                  70    



      <210> 243
      <211> 228
      <212> PRT
      <213> Homo sapiens


      <400> 243
 Met Gly Asn Cys Val Lys Tyr Pro Leu Arg Asn Leu Ser Arg Lys Met
   1               5                  10                  15    
 Cys Gln Glu Glu Gln Thr Ser Tyr Met Val Val Gln Thr Ser Glu Glu
              20                  25                  30        
 Gly Leu Ala Ala Asp Ala Glu Leu Pro Gly Pro Leu Leu Met Leu Ala
          35                  40                  45            
 Gln Asn Cys Ala Val Met His Asn Leu Leu Gly Pro Ala Cys Ile Phe
      50                  55                  60                
 Leu Arg Lys Gly Phe Ala Glu Asn Arg Gln Pro Asp Arg Ser Leu Arg
  65                  70                  75                  80
 Pro Glu Glu Ile Glu Glu Leu Arg Glu Ala Phe Arg Glu Phe Asp Lys
                  85                  90                  95    
 Asp Lys Asp Gly Tyr Ile Asn Cys Arg Asp Leu Gly Asn Trp Met Arg
             100                 105                 110        
 Thr Met Gly Tyr Met Pro Thr Glu Met Glu Leu Ile Glu Leu Ser Gln
         115                 120                 125            
 Gln Ile Asn Met Asn Leu Gly Gly His Val Asp Phe Asp Asp Phe Val
     130                 135                 140                
 Glu Leu Met Gly Pro Lys Leu Leu Ala Glu Thr Ala Asp Met Ile Gly
 145                 150                 155                 160
 Val Lys Glu Leu Arg Asp Ala Phe Arg Glu Phe Asp Thr Asn Gly Asp
                 165                 170                 175    
 Gly Glu Ile Ser Thr Ser Glu Leu Arg Glu Ala Met Arg Lys Leu Leu
             180                 185                 190        
 Gly His Gln Val Gly His Arg Asp Ile Glu Glu Ile Ile Arg Asp Val
         195                 200                 205            
 Asp Leu Asn Gly Asp Gly Arg Val Asp Phe Glu Glu Phe Val Arg Met
     210                 215                 220                
 Met Ser Arg
 225        



      <210> 244
      <211> 265
      <212> PRT
      <213> Homo sapiens


      <400> 244
 Met Ala Val Asp Gln Asp Trp Pro Ser Val Tyr Pro Val Ala Ala Pro
   1               5                  10                  15    
 Phe Lys Pro Ser Ala Val Pro Leu Pro Val Arg Met Gly Tyr Pro Val
              20                  25                  30        
 Lys Lys Gly Val Pro Met Ala Lys Glu Gly Asn Leu Glu Leu Leu Lys
          35                  40                  45            
 Ile Pro Asn Phe Leu His Leu Thr Pro Val Ala Ile Lys Lys His Cys
      50                  55                  60                
 Glu Ala Leu Lys Asp Phe Cys Thr Glu Trp Pro Ala Ala Leu Asp Ser
  65                  70                  75                  80
 Asp Glu Lys Cys Glu Lys His Phe Pro Ile Glu Ile Asp Ser Thr Asp
                  85                  90                  95    
 Tyr Val Ser Ser Gly Pro Ser Val Arg Asn Pro Arg Ala Arg Val Val
             100                 105                 110        
 Val Leu Arg Val Lys Leu Ser Ser Leu Asn Leu Asp Asp His Ala Lys
         115                 120                 125            
 Lys Lys Leu Ile Lys Leu Val Gly Glu Arg Tyr Cys Lys Thr Thr Asp
     130                 135                 140                
 Val Leu Thr Ile Lys Thr Asp Arg Cys Pro Leu Arg Arg Gln Asn Tyr
 145                 150                 155                 160
 Asp Tyr Ala Val Tyr Leu Leu Thr Val Leu Tyr His Glu Ser Trp Asn
                 165                 170                 175    
 Thr Glu Glu Trp Glu Lys Ser Lys Thr Glu Ala Asp Met Glu Glu Tyr
             180                 185                 190        
 Ile Trp Glu Asn Ser Ser Ser Glu Arg Asn Ile Leu Glu Thr Leu Leu
         195                 200                 205            
 Gln Met Lys Ala Ala Glu Lys Asn Met Glu Ile Asn Lys Glu Glu Leu
     210                 215                 220                
 Leu Gly Thr Lys Glu Ile Glu Glu Tyr Lys Lys Ser Val Val Ser Leu
 225                 230                 235                 240
 Lys Asn Glu Glu Glu Asn Glu Asn Ser Ile Ser Gln Tyr Lys Glu Ser
                 245                 250                 255    
 Val Lys Arg Leu Leu Asn Val Thr
             260                



      <210> 245
      <211> 238
      <212> PRT
      <213> Homo sapiens


      <400> 245
 Met Ala Ala Ser Arg Asn Gly Phe Glu Ala Val Glu Ala Glu Gly Ser
   1               5                  10                  15    
 Ala Gly Cys Arg Gly Ser Ser Gly Met Glu Val Val Leu Pro Leu Asp
              20                  25                  30        
 Pro Ala Val Pro Ala Pro Leu Cys Pro His Gly Pro Thr Leu Leu Phe
          35                  40                  45            
 Val Lys Val Thr Gln Gly Lys Glu Glu Thr Arg Arg Phe Tyr Ala Cys
      50                  55                  60                
 Ser Ala Cys Arg Asp Arg Lys Asp Cys Asn Phe Phe Gln Trp Glu Asp
  65                  70                  75                  80
 Glu Lys Leu Ser Gly Ala Arg Leu Ala Ala Arg Glu Ala His Asn Arg
                  85                  90                  95    
 Arg Cys Gln Pro Pro Leu Ser Arg Thr Gln Cys Val Glu Arg Tyr Leu
             100                 105                 110        
 Lys Phe Ile Glu Leu Pro Leu Thr Gln Arg Lys Phe Cys Gln Thr Cys
         115                 120                 125            
 Gln Gln Leu Leu Leu Pro Asp Asp Trp Gly Gln His Ser Glu His Gln
     130                 135                 140                
 Val Leu Gly Asn Val Ser Ile Thr Gln Leu Arg Arg Pro Ser Gln Leu
 145                 150                 155                 160
 Leu Tyr Pro Leu Glu Asn Lys Lys Thr Asn Ala Gln Tyr Leu Phe Ala
                 165                 170                 175    
 Asp Arg Ser Cys Gln Phe Leu Val Asp Leu Leu Ser Ala Leu Gly Phe
             180                 185                 190        
 Arg Arg Val Leu Cys Val Gly Thr Pro Arg Leu His Glu Leu Ile Lys
         195                 200                 205            
 Leu Thr Ala Ser Gly Asp Lys Lys Ser Asn Ile Lys Ser Leu Leu Leu
     210                 215                 220                
 Asp Ile Asp Phe Arg Tyr Ser Gln Phe Leu Tyr Gly Arg
 225                 230                 235        



      <210> 246
      <211> 172
      <212> PRT
      <213> Homo sapiens


      <400> 246
 Met Thr Ser Ala Ser Thr Lys Val Gly Glu Ile Phe Ser Ala Ala Gly
   1               5                  10                  15    
 Ala Ala Phe Thr Lys Leu Gly Glu Leu Thr Met Gln Leu His Pro Val
              20                  25                  30        
 Ala Asp Ser Ser Pro Ala Gly Ala Lys Trp Thr Glu Thr Glu Ile Glu
          35                  40                  45            
 Met Leu Arg Ala Ala Val Lys Arg Phe Gly Asp Asp Leu Asn His Ile
      50                  55                  60                
 Ser Cys Val Ile Lys Glu Arg Thr Val Ala Gln Ile Lys Ala Thr Val
  65                  70                  75                  80
 Lys Arg Lys Val Tyr Glu Asp Ser Gly Ile Pro Leu Pro Ala Glu Ser
                  85                  90                  95    
 Pro Lys Lys Gly Pro Lys Lys Val Ala Ser Gly Val Leu Ser Pro Pro
             100                 105                 110        
 Pro Ala Ala Pro Pro Pro Ser Ser Ser Ser Val Pro Glu Ala Gly Gly
         115                 120                 125            
 Pro Pro Ile Lys Lys Gln Lys Ala Asp Val Thr Leu Ser Ala Leu Asn
     130                 135                 140                
 Asp Ser Asp Ala Asn Ser Asp Val Val Asp Ile Glu Gly Leu Gly Glu
 145                 150                 155                 160
 Thr Pro Pro Ala Lys Lys Leu Asn Phe Asp Gln Ala
                 165                 170        



      <210> 247
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 247
 Met Cys Phe Val Asn Asn Val Phe Ala Gly Ser Met Leu Gly Lys Ser
   1               5                  10                  15    
 His Pro His Pro Pro Phe Leu Ile Asn Gln Gly His Ser Ala Leu Gln
              20                  25                  30        
 Lys Ala Ala Gly Thr Ser Ala Gln Glu Ser Leu Gly Ile Val Gln Gly
          35                  40                  45            
 Phe Pro Pro Leu Arg Gln Pro Glu Ile Trp Pro Arg Gly Lys Gly Lys
      50                  55                  60                
 Ile Leu Pro Ser Pro Ser Pro Thr Pro Val Lys Gly Leu Cys
  65                  70                  75            



      <210> 248
      <211> 245
      <212> PRT
      <213> Homo sapiens


      <400> 248
 Met Ala Pro Arg Lys Gly Ser Ser Arg Val Ala Lys Thr Asn Ser Leu
   1               5                  10                  15    
 Arg Arg Arg Lys Leu Ala Ser Phe Leu Lys Asp Phe Asp Arg Glu Val
              20                  25                  30        
 Glu Ile Arg Ile Lys Gln Ile Glu Ser Asp Arg Gln Asn Leu Leu Lys
          35                  40                  45            
 Glu Val Asp Asn Leu Tyr Asn Ile Glu Ile Leu Arg Leu Pro Lys Ala
      50                  55                  60                
 Leu Arg Glu Met Asn Trp Leu Asp Tyr Phe Ala Leu Gly Gly Asn Lys
  65                  70                  75                  80
 Gln Ala Leu Glu Glu Ala Ala Thr Ala Asp Leu Asp Ile Thr Glu Ile
                  85                  90                  95    
 Asn Lys Leu Thr Ala Glu Ala Ile Gln Thr Pro Leu Lys Ser Ala Lys
             100                 105                 110        
 Thr Arg Lys Val Ile Gln Val Asp Glu Met Ile Val Glu Glu Glu Glu
         115                 120                 125            
 Glu Glu Glu Asn Glu Arg Lys Asn Leu Gln Thr Ala Arg Val Lys Arg
     130                 135                 140                
 Cys Pro Pro Ser Lys Lys Arg Thr Gln Ser Ile Gln Gly Lys Gly Lys
 145                 150                 155                 160
 Gly Lys Arg Ser Ser Arg Ala Asn Thr Val Thr Pro Ala Val Gly Arg
                 165                 170                 175    
 Leu Glu Val Ser Met Val Lys Pro Thr Pro Gly Leu Thr Pro Arg Phe
             180                 185                 190        
 Asp Ser Arg Val Phe Lys Thr Pro Gly Leu Arg Thr Pro Ala Ala Gly
         195                 200                 205            
 Glu Arg Ile Tyr Asn Ile Ser Gly Asn Gly Ser Pro Leu Ala Asp Ser
     210                 215                 220                
 Lys Glu Ile Phe Leu Thr Val Pro Val Gly Gly Gly Glu Ser Pro Ala
 225                 230                 235                 240
 Ile Ile Gly Gln
                



      <210> 249
      <211> 491
      <212> PRT
      <213> Homo sapiens


      <400> 249
 Met Glu Asp Ser Ala Ser Ala Ser Leu Ser Ser Ala Ala Ala Thr Gly
   1               5                  10                  15    
 Thr Ser Thr Ser Thr Pro Ala Ala Pro Thr Ala Arg Lys Gln Leu Asp
              20                  25                  30        
 Lys Glu Gln Val Arg Lys Ala Val Asp Ala Leu Leu Thr His Cys Lys
          35                  40                  45            
 Ser Arg Lys Asn Asn Tyr Gly Leu Leu Leu Asn Glu Asn Glu Ser Leu
      50                  55                  60                
 Phe Leu Met Val Val Leu Trp Lys Ile Pro Ser Lys Glu Leu Arg Val
  65                  70                  75                  80
 Arg Leu Thr Leu Pro His Ser Ile Arg Ser Asp Ser Glu Asp Ile Cys
                  85                  90                  95    
 Leu Phe Thr Lys Asp Glu Pro Asn Ser Thr Pro Glu Lys Thr Glu Gln
             100                 105                 110        
 Phe Tyr Arg Lys Leu Leu Asn Lys His Gly Ile Lys Thr Val Ser Gln
         115                 120                 125            
 Ile Ile Ser Leu Gln Thr Leu Lys Lys Glu Tyr Lys Ser Tyr Glu Ala
     130                 135                 140                
 Lys Leu Arg Leu Leu Ser Ser Phe Asp Phe Phe Leu Thr Asp Asp Arg
 145                 150                 155                 160
 Ile Arg Arg Leu Leu Pro Ser Leu Ile Gly Arg His Phe Tyr Gln Arg
                 165                 170                 175    
 Lys Lys Val Pro Val Ser Val Asn Leu Leu Ser Lys Asn Leu Ser Arg
             180                 185                 190        
 Glu Ile Asn Asp Cys Ile Gly Gly Thr Val Leu Asn Ile Ser Lys Ser
         195                 200                 205            
 Gly Ser Cys Ser Ala Ile Arg Ile Gly His Val Gly Met Gln Ile Glu
     210                 215                 220                
 His Ile Ile Glu Asn Ile Val Ala Val Thr Lys Gly Leu Ser Glu Lys
 225                 230                 235                 240
 Leu Pro Glu Lys Trp Glu Ser Val Lys Leu Leu Phe Val Lys Thr Glu
                 245                 250                 255    
 Lys Ser Ala Ala Leu Pro Ile Phe Ser Ser Phe Val Ser Asn Trp Asp
             260                 265                 270        
 Glu Ala Thr Lys Arg Ser Leu Leu Asn Lys Lys Lys Lys Glu Ala Arg
         275                 280                 285            
 Arg Lys Arg Arg Glu Arg Asn Phe Glu Lys Gln Lys Glu Arg Lys Lys
     290                 295                 300                
 Lys Arg Gln Gln Ala Arg Lys Thr Ala Ser Val Leu Ser Lys Asp Asp
 305                 310                 315                 320
 Val Ala Pro Glu Ser Gly Asp Thr Thr Val Lys Lys Pro Glu Ser Lys
                 325                 330                 335    
 Lys Glu Gln Thr Pro Glu His Gly Lys Lys Lys Arg Gly Arg Gly Lys
             340                 345                 350        
 Ala Gln Val Lys Ala Thr Asn Glu Ser Glu Asp Glu Ile Pro Gln Leu
         355                 360                 365            
 Val Pro Ile Gly Lys Lys Thr Pro Ala Asn Glu Lys Val Glu Ile Gln
     370                 375                 380                
 Lys His Ala Thr Gly Lys Lys Ser Pro Ala Lys Ser Pro Asn Pro Ser
 385                 390                 395                 400
 Thr Pro Arg Gly Lys Lys Arg Lys Ala Leu Pro Ala Ser Glu Thr Pro
                 405                 410                 415    
 Lys Ala Ala Glu Ser Glu Thr Pro Gly Lys Ser Pro Glu Lys Lys Pro
             420                 425                 430        
 Lys Ile Lys Glu Glu Ala Val Lys Glu Lys Ser Pro Ser Leu Gly Lys
         435                 440                 445            
 Lys Asp Ala Arg Gln Thr Pro Lys Lys Pro Glu Ala Lys Phe Phe Thr
     450                 455                 460                
 Thr Pro Ser Lys Ser Val Arg Lys Ala Ser His Thr Pro Lys Lys Trp
 465                 470                 475                 480
 Pro Lys Lys Pro Lys Val Pro Gln Ser Thr
                 485                 490



      <210> 250
      <211> 325
      <212> PRT
      <213> Homo sapiens


      <400> 250
 Met Leu Pro Trp Pro Leu Pro Leu Ala Ser Ser Ala Leu Thr Leu Leu
   1               5                  10                  15    
 Phe Gly Ala Leu Thr Ser Leu Phe Leu Trp Tyr Cys Tyr Arg Leu Gly
              20                  25                  30        
 Ser Gln Asp Met Gln Ala Leu Gly Ala Gly Ser Arg Ala Gly Gly Val
          35                  40                  45            
 Arg Gly Gly Pro Val Gly Cys Ser Glu Ala Gly Gly Pro Ser Pro Gly
      50                  55                  60                
 Gly Pro Gly Asp Pro Gly Glu Gly Pro Arg Thr Glu Gly Leu Val Ser
  65                  70                  75                  80
 Arg Arg Leu Arg Ala Tyr Ala Arg Arg Tyr Ser Trp Ala Gly Met Gly
                  85                  90                  95    
 Arg Val Arg Arg Ala Ala Gln Gly Gly Gly Pro Gly Pro Gly Arg Gly
             100                 105                 110        
 Pro Gly Val Leu Gly Ile Gln Arg Pro Gly Leu Leu Phe Leu Pro Asp
         115                 120                 125            
 Leu Pro Ser Ala Pro Phe Val Pro Arg Asp Ala Gln Arg His Asp Val
     130                 135                 140                
 Glu Leu Leu Glu Ser Ser Phe Pro Ala Ile Leu Arg Asp Phe Gly Ala
 145                 150                 155                 160
 Val Ser Trp Asp Phe Ser Gly Thr Thr Pro Pro Pro Arg Gly Trp Ser
                 165                 170                 175    
 Pro Pro Leu Ala Pro Gly Cys Tyr Gln Leu Leu Leu Tyr Gln Ala Gly
             180                 185                 190        
 Arg Cys Gln Pro Ser Asn Cys Arg Arg Cys Pro Gly Ala Tyr Arg Ala
         195                 200                 205            
 Leu Arg Gly Leu Arg Ser Phe Met Ser Ala Asn Thr Phe Gly Asn Ala
     210                 215                 220                
 Gly Phe Ser Val Leu Leu Pro Gly Ala Arg Leu Glu Gly Arg Cys Gly
 225                 230                 235                 240
 Pro Thr Asn Ala Arg Val Arg Cys His Leu Gly Leu Lys Ile Pro Pro
                 245                 250                 255    
 Gly Cys Glu Leu Val Val Gly Gly Glu Pro Gln Cys Trp Ala Glu Gly
             260                 265                 270        
 His Cys Leu Leu Val Asp Asp Ser Phe Leu His Thr Val Ala His Asn
         275                 280                 285            
 Gly Ser Pro Glu Asp Gly Pro Arg Val Val Phe Ile Val Asp Leu Trp
     290                 295                 300                
 His Pro Asn Val Ala Gly Ala Glu Arg Gln Ala Leu Asp Phe Val Phe
 305                 310                 315                 320
 Ala Pro Asp Pro
                



      <210> 251
      <211> 869
      <212> PRT
      <213> Homo sapiens


      <400> 251
 Met Ala Thr Phe Ile Ser Val Gln Leu Lys Lys Thr Ser Glu Val Asp
   1               5                  10                  15    
 Leu Ala Lys Pro Leu Val Lys Phe Ile Gln Gln Thr Tyr Pro Ser Gly
              20                  25                  30        
 Gly Glu Glu Gln Ala Gln Tyr Cys Arg Ala Ala Glu Glu Leu Ser Lys
          35                  40                  45            
 Leu Arg Arg Ala Ala Val Gly Arg Pro Leu Asp Lys His Glu Gly Ala
      50                  55                  60                
 Leu Glu Thr Leu Leu Arg Tyr Tyr Asp Gln Ile Cys Ser Ile Glu Pro
  65                  70                  75                  80
 Lys Phe Pro Phe Ser Glu Asn Gln Ile Cys Leu Thr Phe Thr Trp Lys
                  85                  90                  95    
 Asp Ala Phe Asp Lys Gly Ser Leu Phe Gly Gly Ser Val Lys Leu Ala
             100                 105                 110        
 Leu Ala Ser Leu Gly Tyr Glu Lys Ser Cys Val Leu Phe Asn Cys Ala
         115                 120                 125            
 Ala Leu Ala Ser Gln Ile Ala Ala Glu Gln Asn Leu Asp Asn Asp Glu
     130                 135                 140                
 Gly Leu Lys Ile Ala Ala Lys His Tyr Gln Phe Ala Ser Gly Ala Phe
 145                 150                 155                 160
 Leu His Ile Lys Glu Thr Val Leu Ser Ala Leu Ser Arg Glu Pro Thr
                 165                 170                 175    
 Val Asp Ile Ser Pro Asp Thr Val Gly Thr Leu Ser Leu Ile Met Leu
             180                 185                 190        
 Ala Gln Ala Gln Glu Val Phe Phe Leu Lys Ala Thr Arg Asp Lys Met
         195                 200                 205            
 Lys Asp Ala Ile Ile Ala Lys Leu Ala Asn Gln Ala Ala Asp Tyr Phe
     210                 215                 220                
 Gly Asp Ala Phe Lys Gln Cys Gln Tyr Lys Asp Thr Leu Pro Lys Glu
 225                 230                 235                 240
 Val Phe Pro Val Leu Ala Ala Lys His Cys Ile Met Gln Ala Asn Ala
                 245                 250                 255    
 Glu Tyr His Gln Ser Ile Leu Ala Lys Gln Gln Lys Lys Phe Gly Glu
             260                 265                 270        
 Glu Ile Ala Arg Leu Gln His Ala Ala Glu Leu Ile Lys Thr Val Ala
         275                 280                 285            
 Ser Arg Tyr Asp Glu Tyr Val Asn Val Lys Asp Phe Ser Asp Lys Ile
     290                 295                 300                
 Asn Arg Ala Leu Ala Ala Ala Lys Lys Asp Asn Asp Phe Ile Tyr His
 305                 310                 315                 320
 Asp Arg Val Pro Asp Leu Lys Asp Leu Asp Pro Ile Gly Lys Ala Thr
                 325                 330                 335    
 Leu Val Lys Ser Thr Pro Val Asn Val Pro Ile Ser Gln Lys Phe Thr
             340                 345                 350        
 Asp Leu Phe Glu Lys Met Val Pro Val Ser Val Gln Gln Ser Leu Ala
         355                 360                 365            
 Ala Tyr Asn Gln Arg Lys Ala Asp Leu Ile Asn Arg Ser Ile Ala Gln
     370                 375                 380                
 Met Arg Glu Ala Thr Thr Leu Ala Asn Gly Val Leu Ala Ser Leu Asn
 385                 390                 395                 400
 Leu Pro Ala Ala Ile Glu Asp Val Ser Gly Asp Thr Val Pro Gln Ser
                 405                 410                 415    
 Ile Leu Thr Lys Ser Arg Ser Val Ile Glu Gln Gly Gly Ile Gln Thr
             420                 425                 430        
 Val Asp Gln Leu Ile Lys Glu Leu Pro Glu Leu Leu Gln Arg Asn Arg
         435                 440                 445            
 Glu Ile Leu Asp Glu Ser Leu Arg Leu Leu Asp Glu Glu Glu Ala Thr
     450                 455                 460                
 Asp Asn Asp Leu Arg Ala Lys Phe Lys Glu Arg Trp Gln Arg Thr Pro
 465                 470                 475                 480
 Ser Asn Glu Leu Tyr Lys Pro Leu Arg Ala Glu Gly Thr Asn Phe Arg
                 485                 490                 495    
 Thr Val Leu Asp Lys Ala Val Gln Ala Asp Gly Gln Val Lys Glu Cys
             500                 505                 510        
 Tyr Gln Ser His Arg Asp Thr Ile Val Leu Leu Cys Lys Pro Glu Pro
         515                 520                 525            
 Glu Leu Asn Ala Ala Ile Pro Ser Ala Asn Pro Ala Lys Thr Met Gln
     530                 535                 540                
 Gly Ser Glu Val Val Asn Val Leu Lys Ser Leu Leu Ser Asn Leu Asp
 545                 550                 555                 560
 Glu Val Lys Lys Glu Arg Glu Gly Leu Glu Asn Asp Leu Lys Ser Val
                 565                 570                 575    
 Asn Phe Asp Met Thr Ser Lys Phe Leu Thr Ala Leu Ala Gln Asp Gly
             580                 585                 590        
 Val Ile Asn Glu Glu Ala Leu Ser Val Thr Glu Leu Asp Arg Val Tyr
         595                 600                 605            
 Gly Gly Leu Thr Thr Lys Val Gln Glu Ser Leu Lys Lys Gln Glu Gly
     610                 615                 620                
 Leu Leu Lys Asn Ile Gln Val Ser His Gln Glu Phe Ser Lys Met Lys
 625                 630                 635                 640
 Gln Ser Asn Asn Glu Ala Asn Leu Arg Glu Glu Val Leu Lys Asn Leu
                 645                 650                 655    
 Ala Thr Ala Tyr Asp Asn Phe Val Glu Leu Val Ala Asn Leu Lys Glu
             660                 665                 670        
 Gly Thr Lys Phe Tyr Asn Glu Leu Thr Glu Ile Leu Val Arg Phe Gln
         675                 680                 685            
 Asn Lys Cys Ser Asp Ile Val Phe Ala Arg Lys Thr Glu Arg Asp Glu
     690                 695                 700                
 Leu Leu Lys Asp Leu Gln Gln Ser Ile Ala Arg Glu Pro Ser Ala Pro
 705                 710                 715                 720
 Ser Ile Pro Thr Pro Ala Tyr Gln Ser Leu Pro Ala Gly Gly His Ala
                 725                 730                 735    
 Pro Thr Pro Pro Thr Pro Ala Pro Arg Thr Met Pro Pro Thr Lys Pro
             740                 745                 750        
 Gln Pro Pro Ala Arg Pro Pro Pro Pro Val Leu Pro Ala Asn Arg Ala
         755                 760                 765            
 Pro Ser Ala Thr Ala Pro Ser Pro Val Gly Ala Gly Thr Ala Ala Pro
     770                 775                 780                
 Ala Pro Ser Gln Thr Pro Gly Ser Ala Pro Pro Pro Gln Ala Gln Gly
 785                 790                 795                 800
 Pro Pro Tyr Pro Thr Tyr Pro Gly Tyr Pro Gly Tyr Cys Gln Met Pro
                 805                 810                 815    
 Met Pro Met Gly Tyr Asn Pro Tyr Ala Tyr Gly Gln Tyr Asn Met Pro
             820                 825                 830        
 Tyr Pro Pro Val Tyr His Gln Ser Pro Gly Gln Ala Pro Tyr Pro Gly
         835                 840                 845            
 Pro Gln Gln Pro Ser Tyr Pro Phe Pro Gln Pro Pro Gln Gln Ser Tyr
     850                 855                 860                
 Tyr Pro Gln Gln
 865            



      <210> 252
      <211> 614
      <212> PRT
      <213> Homo sapiens


      <400> 252
 Met Ala Ala Thr Ala Val Ala Ala Ala Val Ala Gly Thr Glu Ser Ala
   1               5                  10                  15    
 Gln Gly Pro Pro Gly Pro Ala Ala Ser Leu Glu Ile Trp Leu Asn Lys
              20                  25                  30        
 Ala Thr Asp Pro Ser Met Ser Glu Gln Asp Trp Ser Ala Ile Gln Asn
          35                  40                  45            
 Phe Cys Glu Gln Val Asn Thr Asp Pro Asn Gly Pro Thr His Ala Pro
      50                  55                  60                
 Trp Leu Leu Ala His Lys Ile Gln Ser Pro Gln Glu Lys Glu Ala Leu
  65                  70                  75                  80
 Tyr Ala Leu Thr Val Leu Glu Met Cys Met Asn His Cys Gly Glu Lys
                  85                  90                  95    
 Phe His Ser Glu Val Ala Lys Phe Arg Phe Leu Asn Glu Leu Ile Lys
             100                 105                 110        
 Val Leu Ser Pro Lys Tyr Leu Gly Ser Trp Ala Thr Gly Lys Val Lys
         115                 120                 125            
 Gly Arg Val Ile Glu Ile Leu Phe Ser Trp Thr Val Trp Phe Pro Glu
     130                 135                 140                
 Asp Ile Lys Ile Arg Asp Ala Tyr Gln Met Leu Lys Lys Gln Gly Ile
 145                 150                 155                 160
 Ile Lys Gln Asp Pro Lys Leu Pro Val Asp Lys Ile Leu Pro Pro Pro
                 165                 170                 175    
 Ser Pro Trp Pro Lys Ser Ser Ile Phe Asp Ala Asp Glu Glu Lys Ser
             180                 185                 190        
 Lys Leu Leu Thr Arg Leu Leu Lys Ser Asn His Pro Glu Asp Leu Gln
         195                 200                 205            
 Ala Ala Asn Arg Leu Ile Lys Asn Leu Val Lys Glu Glu Gln Glu Lys
     210                 215                 220                
 Ser Glu Lys Val Ser Lys Arg Val Ser Ala Val Glu Glu Val Arg Ser
 225                 230                 235                 240
 His Val Lys Val Leu Gln Glu Met Leu Ser Met Tyr Arg Arg Pro Gly
                 245                 250                 255    
 Gln Ala Pro Pro Asp Gln Glu Ala Leu Gln Val Val Tyr Glu Arg Cys
             260                 265                 270        
 Glu Lys Leu Arg Pro Thr Leu Phe Arg Leu Ala Ser Asp Thr Thr Asp
         275                 280                 285            
 Asp Asp Asp Ala Leu Ala Glu Ile Leu Gln Ala Asn Asp Leu Leu Thr
     290                 295                 300                
 Gln Gly Val Leu Leu Tyr Lys Gln Val Met Glu Gly Arg Val Thr Phe
 305                 310                 315                 320
 Gly Asn Arg Val Thr Ser Ser Leu Gly Asp Ile Pro Val Ser Arg Val
                 325                 330                 335    
 Phe Gln Asn Pro Ala Gly Cys Met Lys Thr Cys Pro Leu Ile Asp Leu
             340                 345                 350        
 Glu Val Asp Asn Gly Pro Ala Gln Met Gly Thr Val Val Pro Ser Leu
         355                 360                 365            
 Leu His Gln Asp Leu Ala Ala Leu Gly Ile Ser Asp Ala Pro Val Thr
     370                 375                 380                
 Gly Met Val Ser Gly Gln Asn Cys Cys Glu Glu Lys Arg Asn Pro Ser
 385                 390                 395                 400
 Ser Ser Thr Leu Pro Gly Gly Gly Val Gln Asn Pro Ser Ala Asp Arg
                 405                 410                 415    
 Asn Leu Leu Asp Leu Leu Ser Pro Gln Pro Ala Pro Cys Pro Leu Asn
             420                 425                 430        
 Tyr Val Ser Gln Lys Ser Val Pro Lys Glu Val Pro Pro Gly Thr Lys
         435                 440                 445            
 Ser Ser Pro Gly Trp Ser Trp Glu Ala Gly Pro Leu Ala Pro Ser Pro
     450                 455                 460                
 Ser Ser Gln Asn Thr Pro Leu Ala Gln Val Phe Val Pro Leu Glu Ser
 465                 470                 475                 480
 Val Lys Pro Ser Ser Leu Pro Pro Leu Ile Val Tyr Asp Arg Asn Gly
                 485                 490                 495    
 Phe Arg Ile Leu Leu His Phe Ser Gln Thr Gly Ala Pro Gly His Pro
             500                 505                 510        
 Glu Val Gln Val Leu Leu Leu Thr Met Met Ser Thr Ala Pro Gln Pro
         515                 520                 525            
 Val Trp Asp Ile Met Phe Gln Val Ala Val Pro Lys Ser Met Arg Val
     530                 535                 540                
 Lys Leu Gln Pro Ala Ser Ser Ser Lys Leu Pro Ala Phe Ser Pro Leu
 545                 550                 555                 560
 Met Pro Pro Ala Val Ile Ser Gln Met Leu Leu Leu Asp Asn Pro His
                 565                 570                 575    
 Lys Glu Pro Ile Arg Leu Arg Tyr Lys Leu Thr Phe Asn Gln Gly Gly
             580                 585                 590        
 Gln Pro Phe Ser Glu Val Gly Glu Val Lys Asp Phe Pro Asp Leu Ala
         595                 600                 605            
 Val Leu Gly Ala Ala
     610            



      <210> 253
      <211> 530
      <212> PRT
      <213> Homo sapiens


      <400> 253
 Met Arg Arg Asn Ser Ser Leu Ser Phe Gln Met Glu Arg Pro Leu Glu
   1               5                  10                  15    
 Glu Gln Val Gln Ser Lys Trp Ser Ser Ser Gln Gly Arg Thr Gly Thr
              20                  25                  30        
 Gly Gly Ser Asp Val Leu Gln Met Gln Asn Ser Glu His His Gly Gln
          35                  40                  45            
 Ser Ile Lys Thr Gln Thr Asp Ser Ile Ser Leu Glu Asp Val Ala Val
      50                  55                  60                
 Asn Phe Thr Leu Glu Glu Trp Ala Leu Leu Asp Pro Gly Gln Arg Asn
  65                  70                  75                  80
 Ile Tyr Arg Asp Val Met Arg Ala Thr Phe Lys Asn Leu Ala Cys Ile
                  85                  90                  95    
 Gly Glu Lys Trp Lys Asp Gln Asp Ile Glu Asp Glu His Lys Asn Gln
             100                 105                 110        
 Gly Arg Asn Leu Arg Ser Pro Met Val Glu Ala Leu Cys Glu Asn Lys
         115                 120                 125            
 Glu Asp Cys Pro Cys Gly Lys Ser Thr Ser Gln Ile Pro Asp Leu Asn
     130                 135                 140                
 Thr Asn Leu Glu Thr Pro Thr Gly Leu Lys Pro Cys Asp Cys Ser Val
 145                 150                 155                 160
 Cys Gly Glu Val Phe Met His Gln Val Ser Leu Asn Arg His Met Arg
                 165                 170                 175    
 Ser His Thr Glu Gln Lys Pro Asn Glu Cys His Glu Tyr Gly Glu Lys
             180                 185                 190        
 Pro His Lys Cys Lys Glu Cys Gly Lys Thr Phe Thr Arg Ser Ser Ser
         195                 200                 205            
 Ile Arg Thr His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys
     210                 215                 220                
 Lys Glu Cys Gly Lys Ala Phe Ala Phe Leu Phe Ser Phe Arg Asn His
 225                 230                 235                 240
 Ile Arg Ile His Thr Gly Glu Thr Pro Tyr Glu Cys Lys Glu Cys Gly
                 245                 250                 255    
 Lys Ala Phe Arg Tyr Leu Thr Ala Leu Arg Arg His Glu Lys Asn His
             260                 265                 270        
 Thr Gly Glu Lys Pro Tyr Lys Cys Lys Gln Cys Gly Lys Ala Phe Ile
         275                 280                 285            
 Tyr Tyr Gln Pro Phe Leu Thr His Glu Arg Thr His Thr Gly Glu Lys
     290                 295                 300                
 Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala Phe Ser Cys Pro Thr Tyr
 305                 310                 315                 320
 Leu Arg Ser His Glu Lys Thr His Thr Gly Glu Lys Pro Phe Val Cys
                 325                 330                 335    
 Arg Glu Cys Gly Arg Ala Phe Phe Ser His Ser Ser Leu Arg Lys His
             340                 345                 350        
 Val Lys Thr His Thr Gly Val Gln Pro Tyr Thr Cys Lys Lys Cys Gly
         355                 360                 365            
 Glu Ala Phe Lys Ser Ser Ser Ser Cys Glu Val His Glu Arg Thr His
     370                 375                 380                
 Phe Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala Phe Asn
 385                 390                 395                 400
 Ser Ser Ser Tyr Leu Gln Leu His Glu Arg Val His Thr Gly Glu Lys
                 405                 410                 415    
 Thr Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Leu Tyr Ser Thr His
             420                 425                 430        
 Phe Arg Ile His Glu Arg Thr His Thr Arg Glu Lys Pro Tyr Glu Cys
         435                 440                 445            
 Lys Gln Cys Gly Arg Val Phe Ile Tyr Phe Ser His Leu Arg Arg His
     450                 455                 460                
 Glu Arg Ser His Thr Gly Val Lys Pro Cys Glu Cys Lys Gln Cys Gly
 465                 470                 475                 480
 Lys Ala Phe Thr Cys Leu Asn Ser Leu Lys Val His Lys Arg Ile His
                 485                 490                 495    
 Thr Gly Glu Arg Pro Phe Gln Cys Arg Gln Cys Gly Lys Ala Phe Ser
             500                 505                 510        
 Tyr Ser Lys Ser Leu His Val His Glu Arg Thr His Ser Arg Gln Lys
         515                 520                 525            
 Pro
    



      <210> 254
      <211> 430
      <212> PRT
      <213> Homo sapiens


      <400> 254
 Met Asp Ser Ser Glu Glu His Ala Gly Cys Pro Ala Arg Gly Thr Cys
   1               5                  10                  15    
 Pro Val Phe Leu Ala Met Ser Ala Gly Thr Val Arg Tyr Ala Pro Ser
              20                  25                  30        
 Gly Leu Cys Pro Val Leu Glu Gly Asn Leu Arg Glu Glu Pro Trp Gly
          35                  40                  45            
 Thr Asp Ser Pro Pro Gln Pro Asp Gln Gly Leu Pro Pro Pro Leu Ala
      50                  55                  60                
 Ala Val Pro Val Pro Trp Lys Ser Thr Asp Pro Cys Gln Gly His Arg
  65                  70                  75                  80
 Glu Ser Pro Gly Ala Leu Val Glu Thr Ser Ala Gly Glu Glu Ala Gln
                  85                  90                  95    
 Gly Gln Glu Gly Pro Ala Ala Ala Gln Leu Asp Val Leu Arg Leu Arg
             100                 105                 110        
 Ser Ser Ser Met Glu Ile Arg Glu Lys Gly Ser Glu Phe Leu Lys Glu
         115                 120                 125            
 Glu Leu His Arg Ala Gln Lys Glu Leu Lys Leu Lys Asp Glu Glu Cys
     130                 135                 140                
 Glu Arg Leu Ser Lys Val Arg Glu Gln Leu Glu Gln Glu Leu Glu Glu
 145                 150                 155                 160
 Leu Thr Ala Ser Leu Phe Glu Glu Ala His Lys Met Val Arg Glu Ala
                 165                 170                 175    
 Asn Met Lys Gln Ala Ala Ser Glu Lys Gln Leu Lys Glu Ala Arg Gly
             180                 185                 190        
 Lys Ile Asp Met Leu Gln Ala Glu Val Thr Ala Leu Lys Thr Leu Val
         195                 200                 205            
 Ile Thr Ser Thr Pro Ala Ser Pro Asn Arg Glu Leu His Pro Gln Leu
     210                 215                 220                
 Leu Ser Pro Thr Lys Ala Gly Pro Arg Lys Gly His Ser Arg His Lys
 225                 230                 235                 240
 Ser Thr Ser Ser Thr Leu Cys Pro Ala Val Cys Pro Ala Ala Gly His
                 245                 250                 255    
 Thr Leu Thr Pro Tyr Arg Glu Gly Lys Glu Val Asp Thr Ile Leu Phe
             260                 265                 270        
 Ala Glu Phe Gln Ala Trp Arg Glu Ser Pro Thr Leu Asp Lys Thr Cys
         275                 280                 285            
 Pro Phe Leu Glu Arg Val Tyr Arg Glu Asp Val Gly Pro Cys Leu Asp
     290                 295                 300                
 Phe Thr Met Gln Glu Leu Ser Val Leu Val Arg Ala Ala Val Glu Asp
 305                 310                 315                 320
 Asn Thr Pro Thr Ile Glu Pro Val Ala Ser Gln Thr Leu Pro Thr Val
                 325                 330                 335    
 Lys Val Ala Glu Val Asp Cys Ser Ser Thr Asn Thr Cys Ala Leu Ser
             340                 345                 350        
 Gly Leu Thr Arg Thr Cys Arg His Arg Ile Arg Leu Gly Asp Ser Lys
         355                 360                 365            
 Ser His Tyr Tyr Ile Ser Pro Ser Ser Arg Ala Arg Ile Thr Ala Val
     370                 375                 380                
 Cys Asn Phe Phe Thr Tyr Ile Arg Tyr Ile Gln Gln Gly Leu Val Arg
 385                 390                 395                 400
 Gln Asp Ala Glu Pro Met Phe Trp Glu Ile Met Arg Leu Arg Lys Glu
                 405                 410                 415    
 Met Ser Leu Ala Lys Leu Gly Phe Phe Pro Gln Glu Ala
             420                 425                



      <210> 255
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 255
 Met Ser Leu Pro Ile Phe Val Phe Ser Phe Asn Leu Glu His Val Phe
   1               5                  10                  15    
 Val Phe Leu Leu Ser Leu Ser Phe Gly Leu Asp Phe Ile Leu Leu Pro
              20                  25                  30        
 Phe Phe Ser Ser Phe Pro Ser Thr Glu Ala Val Gly Lys Phe Ser Gly
          35                  40                  45            
 Leu Ile Thr Arg Gly Ile Leu Arg Ser Pro Arg Ser Phe Ala Phe Ala
      50                  55                  60                
 Met Ala Ser Asp Ile Ile Arg Leu Ala Phe Ser Cys Leu Leu Ser Asp
  65                  70                  75                  80
 Ser Thr Phe Phe Leu Cys Phe Phe Ser Asp Met Thr Leu Thr Trp Val
                  85                  90                  95    
 Phe Cys Asn Leu Val Tyr Val Pro Glu Pro Ser Leu Phe Leu Glu Asp
             100                 105                 110        
 Gly Gly Cys Arg Cys Lys His Arg
         115                 120



      <210> 256
      <211> 368
      <212> PRT
      <213> Homo sapiens


      <400> 256
 Met Asn Ser Ser Pro Ala Gly Thr Pro Ser Pro Gln Pro Ser Arg Ala
   1               5                  10                  15    
 Asn Gly Asn Ile Asn Leu Gly Pro Ser Ala Asn Pro Asn Ala Gln Pro
              20                  25                  30        
 Thr Asp Phe Asp Phe Leu Lys Val Ile Gly Lys Gly Asn Tyr Gly Lys
          35                  40                  45            
 Val Leu Leu Ala Lys Arg Lys Ser Asp Gly Ala Phe Tyr Ala Val Lys
      50                  55                  60                
 Val Leu Gln Lys Lys Ser Ile Leu Lys Lys Lys Glu Gln Ser His Ile
  65                  70                  75                  80
 Met Ala Glu Arg Ser Val Leu Leu Lys Asn Val Arg His Pro Phe Leu
                  85                  90                  95    
 Val Gly Leu Arg Tyr Ser Phe Gln Thr Pro Glu Lys Leu Tyr Phe Val
             100                 105                 110        
 Leu Asp Tyr Val Asn Gly Gly Glu Leu Phe Phe His Leu Gln Arg Glu
         115                 120                 125            
 Arg Arg Phe Leu Glu Pro Arg Ala Arg Phe Tyr Ala Ala Glu Val Ala
     130                 135                 140                
 Ser Ala Ile Gly Tyr Leu His Ser Leu Asn Ile Ile Tyr Arg Asp Leu
 145                 150                 155                 160
 Lys Pro Glu Asn Ile Leu Leu Asp Cys Gln Gly His Val Val Leu Thr
                 165                 170                 175    
 Asp Phe Gly Leu Cys Lys Glu Gly Val Glu Pro Glu Asp Thr Thr Ser
             180                 185                 190        
 Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu Arg Lys
         195                 200                 205            
 Glu Pro Tyr Asp Arg Ala Val Asp Trp Trp Cys Leu Gly Ala Val Leu
     210                 215                 220                
 Tyr Glu Met Leu His Gly Leu Pro Pro Phe Tyr Ser Gln Asp Val Ser
 225                 230                 235                 240
 Gln Met Tyr Glu Asn Ile Leu His Gln Pro Leu Gln Ile Pro Gly Gly
                 245                 250                 255    
 Arg Thr Val Ala Ala Cys Asp Leu Leu Gln Ser Leu Leu His Lys Asp
             260                 265                 270        
 Gln Arg Gln Arg Leu Gly Ser Lys Ala Asp Phe Leu Glu Ile Lys Asn
         275                 280                 285            
 His Val Phe Phe Ser Pro Ile Asn Trp Asp Asp Leu Tyr His Lys Arg
     290                 295                 300                
 Leu Thr Pro Pro Phe Asn Pro Asn Val Thr Gly Pro Ala Asp Leu Lys
 305                 310                 315                 320
 His Phe Asp Pro Glu Phe Thr Gln Glu Ala Val Ser Lys Ser Ile Gly
                 325                 330                 335    
 Cys Thr Pro Asp Thr Val Ala Ser Ser Ser Gly Ala Ser Ser Ala Phe
             340                 345                 350        
 Leu Gly Phe Ser Tyr Ala Pro Glu Asp Asp Asp Ile Leu Asp Cys
         355                 360                 365        



      <210> 257
      <211> 2459
      <212> PRT
      <213> Homo sapiens


      <400> 257
 Met Gly Asp Lys Asp Asp Asp Asp Asp Asp Asp Ala Asp Glu Lys Met
   1               5                  10                  15    
 Gln Ser Ser Gly Ile Pro Asn Gly Gly His Ile Arg Gln Glu Ser Gln
              20                  25                  30        
 Glu Gln Ser Glu Val Asp His Gly Asp Phe Glu Met Val Ser Glu Ser
          35                  40                  45            
 Met Val Leu Glu Thr Ala Glu Asn Val Asn Asn Gly Asn Pro Ser Pro
      50                  55                  60                
 Leu Glu Ala Leu Leu Ala Gly Ala Glu Gly Phe Pro Pro Met Leu Asp
  65                  70                  75                  80
 Ile Pro Pro Asp Ala Asp Asp Glu Thr Met Val Glu Leu Ala Ile Ala
                  85                  90                  95    
 Leu Ser Leu Gln Gln Asp Gln Gln Gly Ser Ser Ser Ser Ala Leu Gly
             100                 105                 110        
 Leu Gln Ser Leu Gly Leu Ser Gly Gln Ala Pro Ser Ser Ser Ser Leu
         115                 120                 125            
 Asp Ala Gly Thr Leu Ser Asp Thr Thr Ala Ser Ala Pro Ala Ser Asp
     130                 135                 140                
 Asp Glu Gly Ser Thr Ala Ala Thr Asp Gly Ser Thr Leu Arg Thr Ser
 145                 150                 155                 160
 Pro Ala Asp His Gly Gly Ser Val Gly Ser Glu Ser Gly Gly Ser Ala
                 165                 170                 175    
 Val Asp Ser Val Ala Gly Glu His Ser Val Ser Gly Arg Ser Ser Ala
             180                 185                 190        
 Tyr Gly Asp Ala Thr Ala Glu Gly His Pro Ala Gly Pro Gly Ser Val
         195                 200                 205            
 Ser Ser Ser Thr Gly Ala Ile Ser Thr Thr Thr Gly His Gln Glu Gly
     210                 215                 220                
 Asp Gly Ser Glu Gly Glu Gly Glu Gly Glu Thr Glu Gly Asp Val His
 225                 230                 235                 240
 Thr Ser Asn Arg Leu His Met Val Arg Leu Met Leu Leu Glu Arg Leu
                 245                 250                 255    
 Leu Gln Thr Leu Pro Gln Leu Arg Asn Val Gly Gly Val Arg Ala Ile
             260                 265                 270        
 Pro Tyr Met Gln Val Ile Leu Met Leu Thr Thr Asp Leu Asp Gly Glu
         275                 280                 285            
 Asp Glu Lys Asp Lys Gly Ala Leu Asp Asn Leu Leu Ser Gln Leu Ile
     290                 295                 300                
 Ala Glu Leu Gly Met Asp Lys Lys Asp Val Ser Lys Lys Asn Glu Arg
 305                 310                 315                 320
 Ser Ala Leu Asn Glu Val His Leu Val Val Met Arg Leu Leu Ser Val
                 325                 330                 335    
 Phe Met Ser Arg Thr Lys Ser Gly Ser Lys Ser Ser Ile Cys Glu Ser
             340                 345                 350        
 Ser Ser Leu Ile Ser Ser Ala Thr Ala Ala Ala Leu Leu Ser Ser Gly
         355                 360                 365            
 Ala Val Asp Tyr Cys Leu His Val Leu Lys Ser Leu Leu Glu Tyr Trp
     370                 375                 380                
 Lys Ser Gln Gln Asn Asp Glu Glu Pro Val Ala Thr Ser Gln Leu Leu
 385                 390                 395                 400
 Lys Pro His Thr Thr Ser Ser Pro Pro Asp Met Ser Pro Phe Phe Leu
                 405                 410                 415    
 Arg Gln Tyr Val Lys Gly His Ala Ala Asp Val Phe Glu Ala Tyr Thr
             420                 425                 430        
 Gln Leu Leu Thr Glu Met Val Leu Arg Leu Pro Tyr Gln Ile Lys Lys
         435                 440                 445            
 Ile Thr Asp Thr Asn Ser Arg Ile Pro Pro Pro Val Phe Asp His Ser
     450                 455                 460                
 Trp Phe Tyr Phe Leu Ser Glu Tyr Leu Met Ile Gln Gln Thr Pro Phe
 465                 470                 475                 480
 Val Arg Arg Gln Val Arg Lys Leu Leu Leu Phe Ile Cys Gly Ser Lys
                 485                 490                 495    
 Glu Lys Tyr Arg Gln Leu Arg Asp Leu His Thr Leu Asp Ser His Val
             500                 505                 510        
 Arg Gly Ile Lys Lys Leu Leu Glu Glu Gln Gly Ile Phe Leu Arg Ala
         515                 520                 525            
 Ser Val Val Thr Ala Ser Ser Gly Ser Ala Leu Gln Tyr Asp Thr Leu
     530                 535                 540                
 Ile Ser Leu Met Glu His Leu Lys Ala Cys Ala Glu Ile Ala Ala Gln
 545                 550                 555                 560
 Arg Thr Ile Asn Trp Gln Lys Phe Cys Ile Lys Asp Asp Ser Val Leu
                 565                 570                 575    
 Tyr Phe Leu Leu Gln Val Ser Phe Leu Val Asp Glu Gly Val Ser Pro
             580                 585                 590        
 Val Leu Leu Gln Leu Leu Ser Cys Ala Leu Cys Gly Ser Lys Val Leu
         595                 600                 605            
 Ala Ala Leu Ala Ala Ser Ser Gly Ser Ser Ser Ala Ser Ser Ser Ser
     610                 615                 620                
 Ala Pro Val Ala Ala Ser Ser Gly Gln Ala Thr Thr Gln Ser Lys Ser
 625                 630                 635                 640
 Ser Thr Lys Lys Ser Lys Lys Glu Glu Lys Glu Lys Glu Lys Asp Gly
                 645                 650                 655    
 Glu Thr Ser Gly Ser Gln Glu Asp Gln Leu Cys Thr Ala Leu Val Asn
             660                 665                 670        
 Gln Leu Asn Lys Phe Ala Asp Lys Glu Thr Leu Ile Gln Phe Leu Arg
         675                 680                 685            
 Cys Phe Leu Leu Glu Ser Asn Ser Ser Ser Val Arg Trp Gln Ala His
     690                 695                 700                
 Cys Leu Thr Leu His Ile Tyr Arg Asn Ser Ser Lys Ser Gln Gln Glu
 705                 710                 715                 720
 Leu Leu Leu Asp Leu Met Trp Ser Ile Trp Pro Glu Leu Pro Ala Tyr
                 725                 730                 735    
 Gly Arg Lys Ala Ala Gln Phe Val Asp Leu Leu Gly Tyr Phe Ser Leu
             740                 745                 750        
 Lys Thr Pro Gln Thr Glu Lys Lys Leu Lys Glu Tyr Ser Gln Lys Ala
         755                 760                 765            
 Val Glu Ile Leu Arg Thr Gln Asn His Ile Leu Thr Asn His Pro Asn
     770                 775                 780                
 Ser Asn Ile Tyr Asn Thr Leu Ser Gly Leu Val Glu Phe Asp Gly Tyr
 785                 790                 795                 800
 Tyr Leu Glu Ser Asp Pro Cys Leu Val Cys Asn Asn Pro Glu Val Pro
                 805                 810                 815    
 Phe Cys Tyr Ile Lys Leu Ser Ser Ile Lys Val Asp Thr Arg Tyr Thr
             820                 825                 830        
 Thr Thr Gln Gln Val Val Lys Leu Ile Gly Ser His Thr Ile Ser Lys
         835                 840                 845            
 Val Thr Val Lys Ile Gly Asp Leu Lys Arg Thr Lys Met Val Arg Thr
     850                 855                 860                
 Ile Asn Leu Tyr Tyr Asn Asn Arg Thr Val Gln Ala Ile Val Glu Leu
 865                 870                 875                 880
 Lys Asn Lys Pro Ala Arg Trp His Lys Ala Lys Lys Val Gln Leu Thr
                 885                 890                 895    
 Pro Gly Gln Thr Glu Val Lys Ile Asp Leu Pro Leu Pro Ile Val Ala
             900                 905                 910        
 Ser Asn Leu Met Ile Glu Phe Ala Asp Phe Tyr Glu Asn Tyr Gln Ala
         915                 920                 925            
 Ser Thr Glu Thr Leu Gln Cys Pro Arg Cys Ser Ala Ser Val Pro Ala
     930                 935                 940                
 Asn Pro Gly Val Cys Gly Asn Cys Gly Glu Asn Val Tyr Gln Cys His
 945                 950                 955                 960
 Lys Cys Arg Ser Ile Asn Tyr Asp Glu Lys Asp Pro Phe Leu Cys Asn
                 965                 970                 975    
 Ala Cys Gly Phe Cys Lys Tyr Ala Arg Phe Asp Phe Met Leu Tyr Ala
             980                 985                 990        
 Lys Pro Cys Cys Ala Val Asp Pro Ile Glu Asn Glu Glu Asp Arg Lys
         995                1000                1005            
 Lys Ala Val Ser Asn Ile Asn Thr Leu Leu Asp Lys Ala Asp Arg Val
    1010                1015                1020                
 Tyr His Gln Leu Met Gly His Arg Pro Gln Leu Glu Asn Leu Leu Cys
1025                1030                1035                1040
 Lys Val Asn Glu Ala Ala Pro Glu Lys Pro Gln Asp Asp Ser Gly Thr
                1045                1050                1055    
 Ala Gly Gly Ile Ser Ser Thr Ser Ala Ser Val Asn Arg Tyr Ile Leu
            1060                1065                1070        
 Gln Leu Ala Gln Glu Tyr Cys Gly Asp Cys Lys Asn Ser Phe Asp Glu
        1075                1080                1085            
 Leu Ser Lys Ile Ile Gln Lys Val Phe Ala Ser Arg Lys Glu Leu Leu
    1090                1095                1100                
 Glu Tyr Asp Leu Gln Gln Arg Glu Ala Ala Thr Lys Ser Ser Arg Thr
1105                1110                1115                1120
 Ser Val Gln Pro Thr Phe Thr Ala Ser Gln Tyr Arg Ala Leu Ser Val
                1125                1130                1135    
 Leu Gly Cys Gly His Thr Ser Ser Thr Lys Cys Tyr Gly Cys Ala Ser
            1140                1145                1150        
 Ala Val Thr Glu His Cys Ile Thr Leu Leu Arg Ala Leu Ala Thr Asn
        1155                1160                1165            
 Pro Ala Leu Arg His Ile Leu Val Ser Gln Gly Leu Ile Arg Glu Leu
    1170                1175                1180                
 Phe Asp Tyr Asn Leu Arg Arg Gly Ala Ala Ala Met Arg Glu Glu Val
1185                1190                1195                1200
 Arg Gln Leu Met Cys Leu Leu Thr Arg Asp Asn Pro Glu Ala Thr Gln
                1205                1210                1215    
 Gln Met Asn Asp Leu Ile Ile Gly Lys Val Ser Thr Ala Leu Lys Gly
            1220                1225                1230        
 His Trp Ala Asn Pro Asp Leu Ala Ser Ser Leu Gln Tyr Glu Met Leu
        1235                1240                1245            
 Leu Leu Thr Asp Ser Ile Ser Lys Glu Asp Ser Cys Trp Glu Leu Arg
    1250                1255                1260                
 Leu Arg Cys Ala Leu Ser Leu Phe Leu Met Ala Val Asn Ile Lys Thr
1265                1270                1275                1280
 Pro Val Val Val Glu Asn Ile Thr Leu Met Cys Leu Arg Ile Leu Gln
                1285                1290                1295    
 Lys Leu Ile Lys Pro Pro Ala Pro Thr Ser Lys Lys Asn Lys Asp Val
            1300                1305                1310        
 Pro Val Glu Ala Leu Thr Thr Val Lys Pro Tyr Cys Asn Glu Ile His
        1315                1320                1325            
 Ala Gln Ala Gln Leu Trp Leu Lys Arg Asp Pro Lys Ala Ser Tyr Asp
    1330                1335                1340                
 Ala Trp Lys Lys Cys Leu Pro Ile Arg Gly Ile Asp Gly Asn Gly Lys
1345                1350                1355                1360
 Ala Pro Ser Lys Ser Glu Leu Arg His Leu Tyr Leu Thr Glu Lys Tyr
                1365                1370                1375    
 Val Trp Arg Trp Lys Gln Phe Leu Ser Arg Arg Gly Lys Arg Thr Ser
            1380                1385                1390        
 Pro Leu Asp Leu Lys Leu Gly His Asn Asn Trp Leu Arg Gln Val Leu
        1395                1400                1405            
 Phe Thr Pro Ala Thr Gln Ala Ala Arg Gln Ala Ala Cys Thr Ile Val
    1410                1415                1420                
 Glu Ala Leu Ala Thr Ile Pro Ser Arg Lys Gln Gln Val Leu Asp Leu
1425                1430                1435                1440
 Leu Thr Ser Tyr Leu Asp Glu Leu Ser Ile Ala Gly Glu Cys Ala Ala
                1445                1450                1455    
 Glu Tyr Leu Ala Leu Tyr Gln Lys Leu Ile Thr Ser Ala His Trp Lys
            1460                1465                1470        
 Val Tyr Leu Ala Ala Arg Gly Val Leu Pro Tyr Val Gly Asn Leu Ile
        1475                1480                1485            
 Thr Lys Glu Ile Ala Arg Leu Leu Ala Leu Glu Glu Ala Thr Leu Ser
    1490                1495                1500                
 Thr Asp Leu Gln Gln Gly Tyr Ala Leu Lys Ser Leu Thr Gly Leu Leu
1505                1510                1515                1520
 Ser Ser Phe Val Glu Val Glu Ser Ile Lys Arg His Phe Lys Ser Arg
                1525                1530                1535    
 Leu Val Gly Thr Val Leu Asn Gly Tyr Leu Cys Leu Arg Lys Leu Val
            1540                1545                1550        
 Val Gln Arg Thr Lys Leu Ile Asp Glu Thr Gln Asp Met Leu Leu Glu
        1555                1560                1565            
 Met Leu Glu Asp Met Thr Thr Gly Thr Glu Ser Glu Thr Lys Ala Phe
    1570                1575                1580                
 Met Ala Val Cys Ile Glu Thr Ala Lys Arg Tyr Asn Leu Asp Asp Tyr
1585                1590                1595                1600
 Arg Thr Pro Val Phe Ile Phe Glu Arg Leu Cys Ser Ile Ile Tyr Pro
                1605                1610                1615    
 Glu Glu Asn Glu Val Thr Glu Phe Phe Val Thr Leu Glu Lys Asp Pro
            1620                1625                1630        
 Gln Gln Glu Asp Phe Leu Gln Gly Arg Met Pro Gly Asn Pro Tyr Ser
        1635                1640                1645            
 Ser Asn Glu Pro Gly Ile Gly Pro Leu Met Arg Asp Ile Lys Asn Lys
    1650                1655                1660                
 Ile Cys Gln Asp Cys Asp Leu Val Ala Leu Leu Glu Asp Asp Ser Gly
1665                1670                1675                1680
 Met Glu Leu Leu Val Asn Asn Lys Ile Ile Ser Leu Asp Leu Pro Val
                1685                1690                1695    
 Ala Glu Val Tyr Lys Lys Val Trp Cys Thr Thr Asn Glu Gly Glu Pro
            1700                1705                1710        
 Met Arg Ile Val Tyr Arg Met Arg Gly Leu Leu Gly Asp Ala Thr Glu
        1715                1720                1725            
 Glu Phe Ile Glu Ser Leu Asp Ser Thr Thr Asp Glu Glu Glu Asp Glu
    1730                1735                1740                
 Glu Glu Val Tyr Lys Met Ala Gly Val Met Ala Gln Cys Gly Gly Leu
1745                1750                1755                1760
 Glu Cys Met Leu Asn Arg Leu Ala Gly Ile Arg Asp Phe Lys Gln Gly
                1765                1770                1775    
 Arg His Leu Leu Thr Val Leu Leu Lys Leu Phe Ser Tyr Cys Val Lys
            1780                1785                1790        
 Val Lys Val Asn Arg Gln Gln Leu Val Lys Leu Glu Met Asn Thr Leu
        1795                1800                1805            
 Asn Val Met Leu Gly Thr Leu Asn Leu Ala Leu Val Ala Glu Gln Glu
    1810                1815                1820                
 Ser Lys Asp Ser Gly Gly Ala Ala Val Ala Glu Gln Val Leu Ser Ile
1825                1830                1835                1840
 Met Glu Ile Ile Leu Asp Glu Ser Asn Ala Glu Pro Leu Ser Glu Asp
                1845                1850                1855    
 Lys Gly Asn Leu Leu Leu Thr Gly Asp Lys Asp Gln Leu Val Met Leu
            1860                1865                1870        
 Leu Asp Gln Ile Asn Ser Thr Phe Val Arg Ser Asn Pro Ser Val Leu
        1875                1880                1885            
 Gln Gly Leu Leu Arg Ile Ile Pro Tyr Leu Ser Phe Gly Glu Val Glu
    1890                1895                1900                
 Lys Met Gln Ile Leu Val Glu Arg Phe Lys Pro Tyr Cys Asn Phe Asp
1905                1910                1915                1920
 Lys Tyr Asp Glu Asp His Ser Gly Asp Asp Lys Val Phe Leu Asp Cys
                1925                1930                1935    
 Phe Cys Lys Ile Ala Ala Gly Ile Lys Asn Asn Ser Asn Gly His Gln
            1940                1945                1950        
 Leu Lys Asp Leu Ile Leu Gln Lys Gly Ile Thr Gln Asn Ala Leu Asp
        1955                1960                1965            
 Tyr Met Lys Lys His Ile Pro Ser Ala Lys Asn Leu Asp Ala Asp Ile
    1970                1975                1980                
 Trp Lys Lys Phe Leu Ser Arg Pro Ala Leu Pro Phe Ile Leu Arg Leu
1985                1990                1995                2000
 Leu Arg Gly Leu Ala Ile Gln His Pro Gly Thr Gln Val Leu Ile Gly
                2005                2010                2015    
 Thr Asp Ser Ile Pro Asn Leu His Lys Leu Glu Gln Val Ser Ser Asp
            2020                2025                2030        
 Glu Gly Ile Gly Thr Leu Ala Glu Asn Leu Leu Glu Ala Leu Arg Glu
        2035                2040                2045            
 His Pro Asp Val Asn Lys Lys Ile Asp Ala Ala Arg Arg Glu Thr Arg
    2050                2055                2060                
 Ala Glu Lys Lys Arg Met Ala Met Ala Met Arg Gln Lys Ala Leu Gly
2065                2070                2075                2080
 Thr Leu Gly Met Thr Thr Asn Glu Lys Gly Gln Val Val Thr Lys Thr
                2085                2090                2095    
 Ala Leu Leu Lys Gln Met Glu Glu Leu Ile Glu Glu Pro Gly Leu Thr
            2100                2105                2110        
 Cys Cys Ile Cys Arg Glu Gly Tyr Lys Phe Gln Pro Thr Lys Val Leu
        2115                2120                2125            
 Gly Ile Tyr Thr Phe Thr Lys Arg Val Ala Leu Glu Glu Met Glu Asn
    2130                2135                2140                
 Lys Pro Arg Lys Gln Gln Gly Tyr Ser Thr Val Ser His Phe Asn Ile
2145                2150                2155                2160
 Val His Tyr Asp Cys His Leu Ala Ala Val Arg Leu Ala Arg Gly Arg
                2165                2170                2175    
 Glu Glu Trp Glu Ser Ala Ala Leu Gln Asn Ala Asn Thr Lys Cys Asn
            2180                2185                2190        
 Gly Leu Leu Pro Val Trp Gly Pro His Val Pro Glu Ser Ala Phe Ala
        2195                2200                2205            
 Thr Cys Leu Ala Arg His Asn Thr Tyr Leu Gln Glu Cys Thr Gly Gln
    2210                2215                2220                
 Arg Glu Pro Thr Tyr Gln Leu Asn Ile His Asp Ile Lys Leu Leu Phe
2225                2230                2235                2240
 Leu Arg Phe Ala Met Glu Gln Ser Phe Ser Ala Asp Thr Gly Gly Gly
                2245                2250                2255    
 Gly Arg Glu Ser Asn Ile His Leu Ile Pro Tyr Ile Ile His Thr Val
            2260                2265                2270        
 Leu Tyr Val Leu Asn Thr Thr Arg Ala Thr Ser Arg Glu Glu Lys Asn
        2275                2280                2285            
 Leu Gln Gly Phe Leu Glu Gln Pro Lys Glu Lys Trp Val Glu Ser Ala
    2290                2295                2300                
 Phe Glu Val Asp Gly Pro Tyr Tyr Phe Thr Val Leu Ala Leu His Ile
2305                2310                2315                2320
 Leu Pro Pro Glu Gln Trp Arg Ala Thr Arg Val Glu Ile Leu Arg Arg
                2325                2330                2335    
 Leu Leu Val Thr Ser Gln Ala Arg Ala Val Ala Pro Gly Gly Ala Thr
            2340                2345                2350        
 Arg Leu Thr Asp Lys Ala Val Lys Asp Tyr Ser Ala Tyr Arg Ser Ser
        2355                2360                2365            
 Leu Leu Phe Trp Ala Leu Val Asp Leu Ile Tyr Asn Met Phe Lys Lys
    2370                2375                2380                
 Val Pro Thr Ser Asn Thr Glu Gly Gly Trp Ser Cys Ser Leu Ala Glu
2385                2390                2395                2400
 Tyr Ile Arg His Asn Asp Met Pro Ile Tyr Glu Ala Ala Asp Lys Ala
                2405                2410                2415    
 Leu Lys Thr Phe Gln Glu Glu Phe Met Pro Val Glu Thr Phe Ser Glu
            2420                2425                2430        
 Phe Leu Asp Val Ala Gly Leu Leu Ser Glu Ile Thr Asp Pro Glu Ser
        2435                2440                2445            
 Phe Leu Lys Asp Leu Leu Asn Ser Val Pro
    2450                2455            



      <210> 258
      <211> 480
      <212> PRT
      <213> Homo sapiens


      <400> 258
 Met Lys Val Arg Ser Ala Gly Gly Asp Gly Asp Ala Leu Cys Val Thr
   1               5                  10                  15    
 Glu Glu Asp Leu Ala Gly Asp Asp Glu Asp Met Pro Thr Phe Pro Cys
              20                  25                  30        
 Thr Gln Lys Gly Arg Pro Gly Pro Arg Cys Ser Arg Cys Gln Lys Asn
          35                  40                  45            
 Leu Ser Leu His Thr Ser Val Arg Ile Leu Tyr Leu Phe Leu Ala Leu
      50                  55                  60                
 Leu Leu Val Ala Val Ala Val Leu Ala Ser Leu Val Phe Arg Lys Val
  65                  70                  75                  80
 Asp Ser Leu Ser Glu Asp Ile Ser Leu Thr Gln Ser Ile Tyr Asp Lys
                  85                  90                  95    
 Lys Leu Val Leu Met Gln Lys Asn Leu Gln Gly Leu Asp Pro Lys Ala
             100                 105                 110        
 Leu Asn Asn Cys Ser Phe Cys His Glu Ala Gly Gln Leu Gly Pro Glu
         115                 120                 125            
 Ile Arg Lys Leu Gln Glu Glu Leu Glu Gly Ile Gln Lys Leu Leu Leu
     130                 135                 140                
 Ala Gln Glu Val Gln Leu Asp Gln Thr Leu Gln Ala Gln Glu Val Leu
 145                 150                 155                 160
 Ser Thr Thr Ser Arg Gln Ile Ser Gln Glu Met Gly Ser Cys Ser Phe
                 165                 170                 175    
 Ser Ile His Gln Val Asn Gln Ser Leu Gly Leu Phe Leu Ala Gln Val
             180                 185                 190        
 Arg Gly Trp Gln Ala Thr Thr Ala Gly Leu Asp Leu Ser Leu Lys Asp
         195                 200                 205            
 Leu Thr Gln Glu Cys Tyr Asp Val Lys Ala Ala Val His Gln Ile Asn
     210                 215                 220                
 Phe Thr Val Gly Gln Thr Ser Glu Trp Ile His Gly Ile Gln Arg Lys
 225                 230                 235                 240
 Thr Asp Glu Glu Thr Leu Thr Leu Gln Lys Ile Val Thr Asp Trp Gln
                 245                 250                 255    
 Asn Tyr Thr Arg Leu Phe Ser Gly Leu Arg Thr Thr Ser Thr Lys Thr
             260                 265                 270        
 Gly Glu Ala Val Lys Asn Ile Gln Ala Thr Leu Gly Ala Ser Ser Gln
         275                 280                 285            
 Arg Ile Ser Gln Asn Ser Glu Ser Met His Asp Leu Val Leu Gln Val
     290                 295                 300                
 Met Gly Leu Gln Leu Gln Leu Asp Asn Ile Ser Ser Phe Leu Asp Asp
 305                 310                 315                 320
 His Glu Glu Asn Met His Asp Leu Gln Tyr His Thr His Tyr Ala Gln
                 325                 330                 335    
 Asn Arg Thr Val Glu Arg Phe Glu Ser Leu Glu Gly Arg Met Ala Ser
             340                 345                 350        
 His Glu Ile Glu Ile Gly Thr Ile Phe Thr Asn Ile Asn Ala Thr Asp
         355                 360                 365            
 Asn His Val His Ser Met Leu Lys Tyr Leu Asp Asp Val Arg Leu Ser
     370                 375                 380                
 Cys Thr Leu Gly Phe His Thr His Ala Glu Glu Leu Tyr Tyr Leu Asn
 385                 390                 395                 400
 Lys Ser Val Ser Ile Met Leu Gly Thr Thr Asp Leu Leu Arg Glu Arg
                 405                 410                 415    
 Phe Ser Leu Leu Ser Ala Arg Leu Asp Leu Asn Val Arg Asn Leu Ser
             420                 425                 430        
 Met Ile Val Glu Glu Met Lys Ala Val Asp Thr Gln His Gly Glu Ile
         435                 440                 445            
 Leu Arg Asn Val Thr Ile Leu Arg Gly Asn Arg Asn Leu Asp Leu Gln
     450                 455                 460                
 Glu Gly Val Glu Ser Ser Arg Ser Gly Lys Leu Glu Arg Lys Tyr
 465                 470                 475                



      <210> 259
      <211> 447
      <212> PRT
      <213> Homo sapiens


      <400> 259
 Met Asn Thr Leu Ser Leu Pro Leu Asn Ile Arg Arg Gly Gly Ser Asp
   1               5                  10                  15    
 Thr Asn Leu Asn Phe Asp Val Pro Asp Gly Ile Leu Asp Phe His Lys
              20                  25                  30        
 Val Lys Leu Thr Ala Asp Ser Leu Lys Gln Lys Ile Leu Lys Val Thr
          35                  40                  45            
 Glu Gln Ile Lys Ile Glu Gln Thr Ser Arg Asp Gly Asn Val Ala Glu
      50                  55                  60                
 Tyr Leu Lys Leu Val Asn Asn Ala Asp Lys Gln Gln Ala Gly Arg Ile
  65                  70                  75                  80
 Lys Gln Val Phe Glu Lys Lys Asn Gln Arg Ala Ala His Ser Ile Ala
                  85                  90                  95    
 Gln Leu Gln Lys Lys Leu Glu Gln Tyr His Arg Lys Leu Arg Glu Ile
             100                 105                 110        
 Glu Gln Asn Gly Ala Ser Arg Ser Ser Lys Asp Ile Ser Lys Asp His
         115                 120                 125            
 Leu Lys Asp Ile His Arg Ser Leu Lys Asp Ala His Val Lys Ser Arg
     130                 135                 140                
 Thr Ala Pro His Cys Met Glu Ser Ser Lys Ser Gly Met Pro Gly Val
 145                 150                 155                 160
 Ser Leu Thr Pro Pro Val Phe Val Phe Asn Lys Ser Arg Glu Phe Ala
                 165                 170                 175    
 Asn Leu Ile Arg Asn Lys Phe Gly Ser Ala Asp Asn Ile Ala His Leu
             180                 185                 190        
 Lys Asn Ser Leu Glu Glu Phe Arg Pro Glu Ala Ser Ala Arg Ala Tyr
         195                 200                 205            
 Gly Gly Ser Ala Thr Ile Val Asn Lys Pro Lys Tyr Gly Ser Asp Asp
     210                 215                 220                
 Glu Cys Ser Ser Gly Thr Ser Gly Ser Ala Asp Ser Asn Gly Asn Gln
 225                 230                 235                 240
 Ser Phe Gly Ala Gly Gly Ala Ser Thr Leu Asp Ser Gln Gly Lys Leu
                 245                 250                 255    
 Ala Val Ile Leu Glu Glu Leu Arg Glu Ile Lys Asp Thr Gln Ala Gln
             260                 265                 270        
 Leu Ala Glu Asp Ile Glu Ala Leu Lys Val Gln Phe Lys Arg Glu Tyr
         275                 280                 285            
 Gly Phe Ile Ser Gln Thr Leu Gln Glu Glu Arg Tyr Arg Tyr Glu Arg
     290                 295                 300                
 Leu Glu Asp Gln Leu His Asp Leu Thr Asp Leu His Gln His Glu Thr
 305                 310                 315                 320
 Ala Asn Leu Lys Gln Glu Leu Ala Ser Ile Glu Glu Lys Val Ala Tyr
                 325                 330                 335    
 Gln Ala Tyr Glu Arg Ser Arg Asp Ile Gln Glu Ala Leu Glu Ser Cys
             340                 345                 350        
 Gln Thr Arg Ile Ser Lys Leu Glu Leu His Gln Gln Glu Gln Gln Ala
         355                 360                 365            
 Leu Gln Thr Asp Thr Val Asn Ala Lys Val Leu Leu Gly Arg Cys Ile
     370                 375                 380                
 Asn Val Ile Leu Ala Phe Met Thr Val Ile Leu Val Cys Val Ser Thr
 385                 390                 395                 400
 Ile Ala Lys Phe Val Ser Pro Met Met Lys Ser Arg Cys His Ile Leu
                 405                 410                 415    
 Gly Thr Phe Phe Ala Val Thr Leu Leu Ala Ile Phe Cys Lys Asn Trp
             420                 425                 430        
 Asp His Ile Leu Cys Ala Ile Glu Arg Met Ile Ile Pro Arg
         435                 440                 445    



      <210> 260
      <211> 1745
      <212> PRT
      <213> Homo sapiens


      <400> 260
 Met Val Ile Asp Pro Leu His Val Thr Leu Thr Pro Lys Lys Leu Lys
   1               5                  10                  15    
 Thr Gly Ile Gly Ser Thr Val Ile Leu Ser Cys Ala Leu Thr Gly Ser
              20                  25                  30        
 Pro Glu Phe Thr Ile Arg Trp Tyr Arg Asn Thr Glu Leu Val Leu Pro
          35                  40                  45            
 Asp Glu Ala Ile Ser Ile Arg Gly Leu Ser Asn Glu Thr Leu Leu Ile
      50                  55                  60                
 Thr Ser Ala Gln Lys Ser His Ser Gly Ala Tyr Gln Cys Phe Ala Thr
  65                  70                  75                  80
 Arg Lys Ala Gln Thr Ala Gln Asp Phe Ala Ile Ile Ala Leu Glu Asp
                  85                  90                  95    
 Gly Thr Pro Arg Ile Val Ser Ser Phe Ser Glu Lys Val Val Asn Pro
             100                 105                 110        
 Gly Glu Gln Phe Ser Leu Met Cys Ala Ala Lys Gly Ala Pro Pro Pro
         115                 120                 125            
 Thr Val Thr Trp Ala Leu Asp Asp Glu Pro Ile Val Arg Asp Gly Ser
     130                 135                 140                
 His Arg Thr Asn Gln Tyr Thr Met Ser Asp Gly Thr Thr Ile Ser His
 145                 150                 155                 160
 Met Asn Val Thr Gly Pro Gln Ile Arg Asp Gly Gly Val Tyr Arg Cys
                 165                 170                 175    
 Thr Ala Arg Asn Leu Val Gly Ser Ala Glu Tyr Gln Ala Arg Ile Asn
             180                 185                 190        
 Val Arg Gly Pro Pro Ser Ile Arg Ala Met Arg Asn Ile Thr Ala Val
         195                 200                 205            
 Ala Gly Arg Asp Thr Leu Ile Asn Cys Arg Val Ile Gly Tyr Pro Tyr
     210                 215                 220                
 Tyr Ser Ile Lys Trp Tyr Lys Asp Ala Leu Leu Leu Pro Asp Asn His
 225                 230                 235                 240
 Arg Gln Val Val Phe Glu Asn Gly Thr Leu Lys Leu Thr Asp Val Gln
                 245                 250                 255    
 Lys Gly Met Asp Glu Gly Glu Tyr Leu Cys Ser Val Leu Ile Gln Pro
             260                 265                 270        
 Gln Leu Ser Ile Ser Gln Ser Val His Val Ala Val Lys Val Pro Pro
         275                 280                 285            
 Leu Ile Gln Pro Phe Glu Phe Pro Pro Ala Ser Ile Gly Gln Leu Leu
     290                 295                 300                
 Tyr Ile Pro Cys Val Val Ser Ser Gly Asp Met Pro Ile Arg Ile Thr
 305                 310                 315                 320
 Trp Arg Lys Asp Gly Gln Val Ile Ile Ser Gly Ser Gly Val Thr Ile
                 325                 330                 335    
 Glu Ser Lys Glu Phe Met Ser Ser Leu Gln Ile Ser Ser Val Ser Leu
             340                 345                 350        
 Lys His Asn Gly Asn Tyr Thr Cys Ile Ala Ser Asn Ala Ala Ala Thr
         355                 360                 365            
 Val Ser Arg Glu Arg Gln Leu Ile Val Arg Val Pro Pro Arg Phe Val
     370                 375                 380                
 Val Gln Pro Asn Asn Gln Asp Gly Ile Tyr Gly Lys Ala Gly Val Leu
 385                 390                 395                 400
 Asn Cys Ser Val Asp Gly Tyr Pro Pro Pro Lys Val Met Trp Lys His
                 405                 410                 415    
 Ala Lys Gly Ser Gly Asn Pro Gln Gln Tyr His Pro Val Pro Leu Thr
             420                 425                 430        
 Gly Arg Ile Gln Ile Leu Pro Asn Ser Ser Leu Leu Ile Arg His Val
         435                 440                 445            
 Leu Glu Glu Asp Ile Gly Tyr Tyr Leu Cys Gln Ala Ser Asn Gly Val
     450                 455                 460                
 Gly Thr Asp Ile Ser Lys Ser Met Phe Leu Thr Val Lys Ile Pro Ala
 465                 470                 475                 480
 Met Ile Thr Ser His Pro Asn Thr Thr Ile Ala Ile Lys Gly His Ala
                 485                 490                 495    
 Lys Glu Leu Asn Cys Thr Ala Arg Gly Glu Arg Pro Ile Ile Ile Arg
             500                 505                 510        
 Trp Glu Lys Gly Asp Thr Val Ile Asp Pro Asp Arg Val Met Arg Tyr
         515                 520                 525            
 Ala Ile Ala Thr Lys Asp Asn Gly Asp Glu Val Val Ser Thr Leu Lys
     530                 535                 540                
 Leu Lys Pro Ala Asp Arg Gly Asp Ser Val Phe Phe Ser Cys His Ala
 545                 550                 555                 560
 Ile Asn Ser Tyr Gly Glu Asp Arg Gly Leu Ile Gln Leu Thr Val Gln
                 565                 570                 575    
 Glu Pro Pro Asp Pro Pro Glu Leu Glu Ile Arg Glu Val Lys Ala Arg
             580                 585                 590        
 Ser Met Asn Leu Arg Trp Thr Gln Arg Phe Asp Gly Asn Ser Ile Ile
         595                 600                 605            
 Thr Gly Phe Asp Ile Glu Tyr Lys Asn Lys Ser Asp Ser Trp Asp Phe
     610                 615                 620                
 Lys Gln Ser Thr Arg Asn Ile Ser Pro Thr Ile Asn Gln Ala Asn Ile
 625                 630                 635                 640
 Val Asp Leu His Pro Ala Ser Val Tyr Ser Ile Arg Met Tyr Ser Phe
                 645                 650                 655    
 Asn Lys Ile Gly Arg Ser Glu Pro Ser Lys Glu Leu Thr Ile Ser Thr
             660                 665                 670        
 Glu Glu Ala Ala Pro Asp Gly Pro Pro Met Asp Val Thr Leu Gln Pro
         675                 680                 685            
 Val Thr Ser Gln Ser Ile Gln Val Thr Trp Lys Ala Pro Lys Lys Glu
     690                 695                 700                
 Leu Gln Asn Gly Val Ile Arg Gly Tyr Gln Ile Gly Tyr Arg Glu Asn
 705                 710                 715                 720
 Ser Pro Gly Ser Asn Gly Gln Tyr Ser Ile Val Glu Met Lys Ala Thr
                 725                 730                 735    
 Gly Asp Ser Glu Val Tyr Thr Leu Asp Asn Leu Lys Lys Phe Ala Gln
             740                 745                 750        
 Tyr Gly Val Val Val Gln Ala Phe Asn Arg Ala Gly Thr Gly Pro Ser
         755                 760                 765            
 Ser Ser Glu Ile Asn Ala Thr Thr Leu Glu Asp Val Pro Ser Gln Pro
     770                 775                 780                
 Pro Glu Asn Val Arg Ala Leu Ser Ile Thr Ser Asp Val Ala Val Ile
 785                 790                 795                 800
 Ser Trp Ser Glu Pro Pro Arg Ser Thr Leu Asn Gly Val Leu Lys Gly
                 805                 810                 815    
 Tyr Arg Val Ile Phe Trp Ser Leu Tyr Val Asp Gly Glu Trp Gly Glu
             820                 825                 830        
 Met Gln Asn Ile Thr Thr Thr Arg Glu Arg Val Glu Leu Arg Gly Met
         835                 840                 845            
 Glu Lys Phe Thr Asn Tyr Ser Val Gln Val Leu Ala Tyr Thr Gln Ala
     850                 855                 860                
 Gly Asp Gly Val Arg Ser Ser Val Leu Tyr Ile Gln Thr Lys Glu Asp
 865                 870                 875                 880
 Val Pro Gly Pro Pro Ala Gly Ile Lys Ala Val Pro Ser Ser Ala Ser
                 885                 890                 895    
 Ser Val Val Val Ser Trp Leu Pro Pro Thr Lys Pro Asn Gly Val Ile
             900                 905                 910        
 Arg Lys Tyr Thr Ile Phe Cys Ser Ser Pro Gly Ser Gly Gln Pro Ala
         915                 920                 925            
 Pro Ser Glu Tyr Glu Thr Ser Pro Glu Gln Leu Phe Tyr Arg Ile Ala
     930                 935                 940                
 His Leu Asn Arg Gly Gln Gln Tyr Leu Leu Trp Val Ala Ala Val Thr
 945                 950                 955                 960
 Ser Ala Gly Arg Gly Asn Ser Ser Glu Lys Val Thr Ile Glu Pro Ala
                 965                 970                 975    
 Gly Lys Ala Pro Ala Lys Ile Ile Ser Phe Gly Gly Thr Val Thr Thr
             980                 985                 990        
 Pro Trp Met Lys Asp Val Arg Leu Pro Cys Asn Ser Val Gly Asp Pro
         995                1000                1005            
 Ala Pro Ala Val Lys Trp Thr Lys Asp Ser Glu Asp Ser Ala Ile Pro
    1010                1015                1020                
 Val Ser Met Asp Gly His Arg Leu Ile His Thr Asn Gly Thr Leu Leu
1025                1030                1035                1040
 Leu Arg Ala Val Lys Ala Glu Asp Ser Gly Tyr Tyr Thr Cys Thr Ala
                1045                1050                1055    
 Thr Asn Thr Gly Gly Phe Asp Thr Ile Ile Val Asn Leu Leu Val Gln
            1060                1065                1070        
 Val Pro Pro Asp Gln Pro Arg Leu Thr Val Ser Lys Thr Ser Ala Ser
        1075                1080                1085            
 Ser Ile Thr Leu Thr Trp Ile Pro Gly Asp Asn Gly Gly Ser Ser Ile
    1090                1095                1100                
 Arg Gly Phe Val Leu Gln Tyr Ser Val Asp Asn Ser Glu Glu Trp Lys
1105                1110                1115                1120
 Asp Val Phe Ile Ser Ser Ser Glu Arg Ser Phe Lys Leu Asp Ser Leu
                1125                1130                1135    
 Lys Cys Gly Thr Trp Tyr Lys Val Lys Leu Ala Ala Lys Asn Ser Val
            1140                1145                1150        
 Gly Ser Gly Arg Ile Ser Glu Ile Ile Glu Ala Lys Thr His Gly Arg
        1155                1160                1165            
 Glu Pro Ser Phe Ser Lys Asp Gln His Leu Phe Thr His Ile Asn Ser
    1170                1175                1180                
 Thr His Ala Arg Leu Asn Leu Gln Gly Trp Asn Asn Gly Gly Cys Pro
1185                1190                1195                1200
 Ile Thr Ala Ile Val Leu Glu Tyr Arg Pro Lys Gly Thr Trp Ala Trp
                1205                1210                1215    
 Gln Gly Leu Arg Ala Asn Ser Ser Gly Glu Val Phe Leu Thr Glu Leu
            1220                1225                1230        
 Arg Glu Ala Thr Trp Tyr Glu Leu Arg Met Arg Ala Cys Asn Ser Ala
        1235                1240                1245            
 Gly Cys Gly Asn Glu Thr Ala Gln Phe Ala Thr Leu Asp Tyr Asp Gly
    1250                1255                1260                
 Ser Thr Ile Pro Pro Ile Lys Ser Ala Gln Gly Glu Gly Asp Asp Val
1265                1270                1275                1280
 Lys Lys Leu Phe Thr Ile Gly Cys Pro Val Ile Leu Ala Thr Leu Gly
                1285                1290                1295    
 Val Ala Leu Leu Phe Ile Val Arg Lys Lys Arg Lys Glu Lys Arg Leu
            1300                1305                1310        
 Lys Arg Leu Arg Asp Ala Lys Ser Leu Ala Glu Met Leu Ile Ser Lys
        1315                1320                1325            
 Asn Asn Arg Ser Phe Asp Thr Pro Val Lys Gly Pro Pro Gln Gly Pro
    1330                1335                1340                
 Arg Leu His Ile Asp Ile Pro Arg Val Gln Leu Leu Ile Glu Asp Lys
1345                1350                1355                1360
 Glu Gly Ile Lys Gln Leu Gly Asp Asp Lys Ala Thr Ile Pro Val Thr
                1365                1370                1375    
 Asp Ala Glu Phe Ser Gln Ala Val Asn Pro Gln Ser Phe Cys Thr Gly
            1380                1385                1390        
 Val Ser Leu His His Pro Thr Leu Ile Gln Ser Thr Gly Pro Leu Ile
        1395                1400                1405            
 Asp Met Ser Asp Ile Arg Pro Gly Thr Asn Pro Val Ser Arg Lys Asn
    1410                1415                1420                
 Val Lys Ser Ala His Ser Thr Arg Asn Arg Tyr Ser Ser Gln Trp Thr
1425                1430                1435                1440
 Leu Thr Lys Cys Gln Ala Ser Thr Pro Ala Arg Thr Leu Thr Ser Asp
                1445                1450                1455    
 Trp Arg Thr Val Gly Ser Gln His Gly Val Thr Val Thr Glu Ser Asp
            1460                1465                1470        
 Ser Tyr Ser Ala Ser Leu Ser Gln Asp Thr Asp Lys Gly Arg Asn Ser
        1475                1480                1485            
 Met Val Ser Thr Glu Ser Ala Ser Ser Thr Tyr Glu Glu Leu Ala Arg
    1490                1495                1500                
 Ala Tyr Glu His Ala Lys Leu Glu Glu Gln Leu Gln His Ala Lys Phe
1505                1510                1515                1520
 Glu Ile Thr Glu Cys Phe Ile Ser Asp Ser Ser Ser Asp Gln Met Thr
                1525                1530                1535    
 Thr Gly Thr Asn Glu Asn Ala Asp Ser Met Thr Ser Met Ser Thr Pro
            1540                1545                1550        
 Ser Glu Pro Gly Ile Cys Arg Phe Thr Ala Ser Pro Pro Lys Pro Gln
        1555                1560                1565            
 Asp Ala Asp Arg Gly Lys Asn Val Ala Val Pro Ile Pro His Arg Ala
    1570                1575                1580                
 Asn Lys Ser Asp Tyr Cys Asn Leu Pro Leu Tyr Ala Lys Ser Glu Ala
1585                1590                1595                1600
 Phe Phe Arg Lys Ala Asp Gly Arg Glu Pro Cys Pro Val Val Pro Pro
                1605                1610                1615    
 Arg Glu Ala Ser Ile Arg Asn Leu Ala Arg Thr Tyr His Thr Gln Ala
            1620                1625                1630        
 Arg His Leu Thr Leu Asp Pro Ala Ser Lys Ser Leu Gly Leu Pro His
        1635                1640                1645            
 Pro Gly Ala Pro Ala Ala Ala Ser Thr Ala Thr Leu Pro Gln Arg Thr
    1650                1655                1660                
 Leu Ala Met Pro Ala Pro Pro Ala Gly Thr Ala Pro Pro Ala Pro Gly
1665                1670                1675                1680
 Pro Thr Pro Ala Glu Pro Pro Thr Ala Pro Ser Ala Ala Pro Pro Ala
                1685                1690                1695    
 Pro Ser Thr Glu Pro Pro Arg Ala Gly Gly Pro His Thr Lys Met Gly
            1700                1705                1710        
 Gly Ser Arg Asp Ser Leu Leu Glu Met Ser Thr Ser Gly Val Gly Arg
        1715                1720                1725            
 Ser Gln Lys Gln Gly Ala Gly Ala Tyr Ser Lys Ser Tyr Thr Leu Val
    1730                1735                1740                





      <210> 261
      <211> 790
      <212> PRT
      <213> Homo sapiens


      <400> 261
 Met Glu Thr Leu Leu Gly Gly Leu Leu Ala Phe Gly Met Ala Phe Ala
   1               5                  10                  15    
 Val Val Asp Ala Cys Pro Lys Tyr Cys Val Cys Gln Asn Leu Ser Glu
              20                  25                  30        
 Ser Leu Gly Thr Leu Cys Pro Ser Lys Gly Leu Leu Phe Val Pro Pro
          35                  40                  45            
 Asp Ile Asp Arg Arg Thr Val Glu Leu Arg Leu Gly Gly Asn Phe Ile
      50                  55                  60                
 Ile His Ile Ser Arg Gln Asp Phe Ala Asn Met Thr Gly Leu Val Asp
  65                  70                  75                  80
 Leu Thr Leu Ser Arg Asn Thr Ile Ser His Ile Gln Pro Phe Ser Phe
                  85                  90                  95    
 Leu Asp Leu Glu Ser Leu Arg Ser Leu His Leu Asp Ser Asn Arg Leu
             100                 105                 110        
 Pro Ser Leu Gly Glu Asp Thr Leu Arg Gly Leu Val Asn Leu Gln His
         115                 120                 125            
 Leu Ile Val Asn Asn Asn Gln Leu Gly Gly Ile Ala Asp Glu Ala Phe
     130                 135                 140                
 Glu Asp Phe Leu Leu Thr Leu Glu Asp Leu Asp Leu Ser Tyr Asn Asn
 145                 150                 155                 160
 Leu His Gly Leu Pro Trp Asp Ser Val Arg Arg Met Val Asn Leu His
                 165                 170                 175    
 Gln Leu Ser Leu Asp His Asn Leu Leu Asp His Ile Ala Glu Gly Thr
             180                 185                 190        
 Phe Ala Asp Leu Gln Lys Leu Ala Arg Leu Asp Leu Thr Ser Asn Arg
         195                 200                 205            
 Leu Gln Lys Leu Pro Pro Asp Pro Ile Phe Ala Arg Ser Gln Ala Ser
     210                 215                 220                
 Ala Leu Thr Ala Thr Pro Phe Ala Pro Pro Leu Ser Phe Ser Phe Gly
 225                 230                 235                 240
 Gly Asn Pro Leu His Cys Asn Cys Glu Leu Leu Trp Leu Arg Arg Leu
                 245                 250                 255    
 Glu Arg Asp Asp Asp Leu Glu Thr Cys Gly Ser Pro Gly Gly Leu Lys
             260                 265                 270        
 Gly Arg Tyr Phe Trp His Val Arg Glu Glu Glu Phe Val Cys Glu Pro
         275                 280                 285            
 Pro Leu Ile Thr Gln His Thr His Lys Leu Leu Val Leu Glu Gly Gln
     290                 295                 300                
 Ala Ala Thr Leu Lys Cys Lys Ala Ile Gly Asp Pro Ser Pro Leu Ile
 305                 310                 315                 320
 His Trp Val Ala Pro Asp Asp Arg Leu Val Gly Asn Ser Ser Arg Thr
                 325                 330                 335    
 Ala Val Tyr Asp Asn Gly Thr Pro Asp Ile Phe Ile Thr Thr Ser Gln
             340                 345                 350        
 Asp Ser Gly Ala Phe Thr Cys Ile Ala Ala Asn Ala Ala Gly Glu Ala
         355                 360                 365            
 Thr Ala Met Val Glu Val Ser Ile Val Gln Leu Pro His Leu Ser Asn
     370                 375                 380                
 Ser Thr Ser Arg Thr Ala Pro Pro Lys Ser Arg Leu Ser Asp Ile Thr
 385                 390                 395                 400
 Gly Ser Ser Lys Thr Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Glu
                 405                 410                 415    
 Pro Pro Lys Ser Pro Pro Glu Arg Ala Val Leu Val Ser Glu Val Thr
             420                 425                 430        
 Thr Thr Ser Ala Leu Val Lys Trp Ser Val Ser Lys Ser Ala Pro Arg
         435                 440                 445            
 Val Lys Met Tyr Gln Leu Gln Tyr Asn Cys Ser Asp Asp Glu Val Leu
     450                 455                 460                
 Ile Tyr Arg Met Ile Pro Ala Ser Asn Lys Ala Phe Val Val Asn Asn
 465                 470                 475                 480
 Leu Val Ser Gly Thr Gly Tyr Asp Leu Cys Val Leu Ala Met Trp Asp
                 485                 490                 495    
 Asp Thr Ala Thr Thr Leu Thr Ala Thr Asn Ile Val Gly Cys Ala Gln
             500                 505                 510        
 Phe Phe Thr Lys Ala Asp Tyr Pro Gln Cys Gln Ser Met His Ser Gln
         515                 520                 525            
 Ile Leu Gly Gly Thr Met Ile Leu Val Ile Gly Gly Ile Ile Val Ala
     530                 535                 540                
 Thr Leu Leu Val Phe Ile Val Ile Leu Met Val Arg Tyr Lys Val Cys
 545                 550                 555                 560
 Asn His Glu Ala Pro Ser Lys Met Ala Ala Ala Val Ser Asn Val Tyr
                 565                 570                 575    
 Ser Gln Thr Asn Gly Ala Gln Pro Pro Pro Pro Ser Ser Ala Pro Ala
             580                 585                 590        
 Gly Ala Pro Pro Gln Gly Pro Pro Lys Val Val Val Arg Asn Glu Leu
         595                 600                 605            
 Leu Asp Phe Thr Ala Ser Leu Ala Arg Ala Ser Asp Ser Ser Ser Ser
     610                 615                 620                
 Ser Ser Leu Gly Ser Gly Glu Ala Ala Gly Leu Gly Arg Ala Pro Trp
 625                 630                 635                 640
 Arg Ile Pro Pro Ser Ala Pro Arg Pro Lys Pro Ser Leu Asp Arg Leu
                 645                 650                 655    
 Met Gly Ala Phe Ala Ser Leu Asp Leu Lys Ser Gln Arg Lys Glu Glu
             660                 665                 670        
 Leu Leu Asp Ser Arg Thr Pro Ala Gly Arg Gly Ala Gly Thr Ser Ala
         675                 680                 685            
 Arg Gly His His Ser Asp Arg Glu Pro Leu Leu Gly Pro Pro Ala Ala
     690                 695                 700                
 Arg Ala Arg Ser Leu Leu Pro Leu Pro Leu Glu Gly Lys Ala Lys Arg
 705                 710                 715                 720
 Ser His Ser Phe Asp Met Gly Asp Phe Ala Ala Ala Ala Ala Gly Gly
                 725                 730                 735    
 Val Val Pro Gly Gly Tyr Ser Pro Pro Arg Lys Val Ser Asn Ile Trp
             740                 745                 750        
 Thr Lys Arg Ser Leu Ser Val Asn Gly Met Leu Leu Pro Phe Glu Glu
         755                 760                 765            
 Ser Asp Leu Val Gly Ala Arg Gly Thr Phe Gly Ser Ser Glu Trp Val
     770                 775                 780                
 Met Glu Ser Thr Val
 785                



      <210> 262
      <211> 494
      <212> PRT
      <213> Homo sapiens


      <400> 262
 Met Asn Arg Thr Lys Gly Asp Glu Glu Glu Tyr Trp Asn Ser Ser Lys
   1               5                  10                  15    
 Phe Lys Ala Phe Thr Phe Asp Asp Glu Asp Asp Glu Leu Ser Gln Leu
              20                  25                  30        
 Lys Glu Ser Lys Arg Ala Val Asn Ser Leu Arg Asp Phe Val Asp Asp
          35                  40                  45            
 Asp Asp Asp Asp Asp Leu Glu Arg Val Ser Trp Ser Gly Glu Pro Val
      50                  55                  60                
 Gly Ser Ile Ser Trp Ser Ile Arg Glu Thr Ala Gly Asn Ser Gly Ser
  65                  70                  75                  80
 Thr His Glu Gly Arg Glu Gln Leu Lys Ser Arg Asn Ser Phe Ser Ser
                  85                  90                  95    
 Tyr Ala Gln Leu Pro Lys Pro Thr Ser Thr Tyr Ser Leu Ser Ser Phe
             100                 105                 110        
 Phe Arg Gly Arg Thr Arg Pro Gly Ser Phe Gln Ser Leu Ser Asp Ala
         115                 120                 125            
 Leu Ser Asp Thr Pro Ala Lys Ser Tyr Ala Pro Glu Leu Gly Arg Pro
     130                 135                 140                
 Lys Gly Glu Tyr Arg Asp Tyr Ser Asn Asp Trp Ser Pro Ser Asp Thr
 145                 150                 155                 160
 Val Arg Arg Leu Arg Lys Gly Lys Val Cys Ser Leu Glu Arg Phe Arg
                 165                 170                 175    
 Ser Leu Gln Asp Lys Leu Gln Leu Leu Glu Glu Ala Val Ser Met His
             180                 185                 190        
 Asp Gly Asn Val Ile Thr Ala Val Leu Ile Phe Leu Lys Arg Thr Leu
         195                 200                 205            
 Ser Lys Glu Ile Leu Phe Arg Glu Leu Glu Val Arg Gln Val Ala Leu
     210                 215                 220                
 Arg His Leu Ile His Phe Leu Lys Glu Ile Gly Asp Gln Lys Leu Leu
 225                 230                 235                 240
 Leu Asp Leu Phe Arg Phe Leu Asp Arg Thr Glu Glu Leu Ala Leu Ser
                 245                 250                 255    
 His Tyr Arg Glu His Leu Asn Ile Gln Asp Pro Asp Lys Arg Lys Glu
             260                 265                 270        
 Phe Leu Lys Thr Cys Val Gly Leu Pro Phe Ser Ala Glu Asp Ser Ala
         275                 280                 285            
 His Ile Gln Asp His Tyr Thr Leu Leu Glu Arg Gln Ile Ile Ile Glu
     290                 295                 300                
 Ala Asn Asp Arg His Leu Glu Ser Ala Gly Gln Thr Glu Ile Phe Arg
 305                 310                 315                 320
 Lys His Pro Arg Lys Ala Ser Ile Leu Asn Met Pro Leu Val Thr Thr
                 325                 330                 335    
 Leu Phe Tyr Ser Cys Phe Tyr His Tyr Thr Glu Ala Glu Gly Thr Phe
             340                 345                 350        
 Ser Ser Pro Val Asn Leu Lys Lys Thr Phe Lys Ile Pro Asp Lys Gln
         355                 360                 365            
 Tyr Val Leu Thr Ala Leu Ala Ala Arg Ala Lys Leu Arg Ala Trp Asn
     370                 375                 380                
 Asp Val Asp Ala Leu Phe Thr Thr Lys Asn Trp Leu Gly Tyr Thr Lys
 385                 390                 395                 400
 Lys Arg Ala Pro Ile Gly Phe His Arg Val Val Glu Ile Leu His Lys
                 405                 410                 415    
 Asn Asn Ala Pro Val Gln Ile Leu Gln Glu Tyr Val Asn Leu Val Glu
             420                 425                 430        
 Asp Val Asp Thr Lys Leu Asn Leu Ala Thr Lys Phe Lys Cys His Asp
         435                 440                 445            
 Val Val Ile Asp Thr Tyr Arg Asp Leu Lys Asp Arg Gln Gln Leu Leu
     450                 455                 460                
 Ala Tyr Arg Ser Lys Val Asp Lys Gly Ser Ala Glu Glu Glu Lys Ile
 465                 470                 475                 480
 Asp Ala Leu Leu Ser Ser Ser Gln Ile Arg Trp Lys Asn
                 485                 490            



      <210> 263
      <211> 74
      <212> PRT
      <213> Homo sapiens


      <400> 263
 Met Glu Ser Arg Ser Val Thr Gln Ala Gly Val Gln Trp Arg Tyr Leu
   1               5                  10                  15    
 Ser Ser Leu Gln Ala Trp Pro Pro Gly Phe Thr Pro Phe Ser Cys Leu
              20                  25                  30        
 Ser Leu Pro Ser Ser Trp Asp Tyr Arg His Pro Pro Pro Arg Pro Ala
          35                  40                  45            
 Asn Phe Leu Tyr Phe Ser Leu Val Glu Thr Glu Phe Gln Arg Ala Ser
      50                  55                  60                
 Gln Asp Gly Leu Asn Leu Leu Thr Ser
  65                  70            



      <210> 264
      <211> 92
      <212> PRT
      <213> Homo sapiens


      <400> 264
 Met Val Gly Arg Phe Phe Leu Leu Phe Val Phe Tyr Phe Ile Phe Phe
   1               5                  10                  15    
 Phe Leu Phe Phe Phe Lys Thr Glu Ser His Ser Val Val Gln Ala Gly
              20                  25                  30        
 Val Gln Trp Cys Asn Leu Gly Ser Leu Gln Pro Pro Pro Pro Arg Phe
          35                  40                  45            
 Lys Gln Phe Ser Cys His Ser Leu Ile Ser Ser Trp Asp Tyr Arg Ser
      50                  55                  60                
 Val Pro Pro Ser Pro Gly Asn Phe Leu Ile Phe Ser Ser Lys Trp Gly
  65                  70                  75                  80
 Phe Thr Met Val Ala Arg Leu Val Trp Asn Ser
                  85                  90    



      <210> 265
      <211> 81
      <212> PRT
      <213> Homo sapiens


      <400> 265
 Met Gly Gly Glu Gln Glu Arg Gly Arg Thr Gly Ala Ser Trp Lys Thr
   1               5                  10                  15    
 Ile Thr Ala Ile Leu Gln Pro Gly Gln His Gly Glu Thr Leu Phe Leu
              20                  25                  30        
 Ile Lys Thr Gln Lys Leu Gly Pro Gly Met Val Ala His Thr Cys Asn
          35                  40                  45            
 Pro Ser Thr Leu Gly Gly Gln Gly Gly Trp Ile Pro Arg Ser Arg Asp
      50                  55                  60                
 Arg Asp His Pro Gly Gln Arg Ser Glu Thr Pro Ser Leu Leu Lys Leu
  65                  70                  75                  80





      <210> 266
      <211> 316
      <212> PRT
      <213> Homo sapiens


      <400> 266
 Met Ala Ala Gly Val Pro Cys Ala Leu Val Thr Ser Cys Ser Ser Val
   1               5                  10                  15    
 Phe Ser Gly Asp Gln Leu Val Gln His Ile Leu Gly Thr Glu Asp Leu
              20                  25                  30        
 Ile Val Glu Val Thr Ser Asn Asp Ala Val Arg Phe Tyr Pro Trp Thr
          35                  40                  45            
 Ile Asp Asn Lys Tyr Tyr Ser Ala Asp Ile Asn Leu Cys Val Val Pro
      50                  55                  60                
 Asn Lys Phe Leu Val Thr Ala Glu Ile Ala Glu Ser Val Gln Ala Phe
  65                  70                  75                  80
 Val Val Tyr Phe Asp Ser Thr Gln Lys Ser Gly Leu Asp Ser Val Ser
                  85                  90                  95    
 Ser Trp Leu Pro Leu Ala Lys Ala Trp Leu Pro Glu Val Met Ile Leu
             100                 105                 110        
 Val Cys Asp Arg Val Ser Glu Asp Gly Ile Asn Arg Gln Lys Ala Gln
         115                 120                 125            
 Glu Trp Cys Ile Lys His Gly Phe Glu Leu Val Glu Leu Ser Pro Glu
     130                 135                 140                
 Glu Leu Pro Glu Glu Asp Asp Asp Phe Pro Glu Ser Thr Gly Val Lys
 145                 150                 155                 160
 Arg Ile Val Gln Ala Leu Asn Ala Asn Val Trp Ser Asn Val Val Met
                 165                 170                 175    
 Lys Asn Asp Arg Asn Gln Gly Phe Ser Leu Leu Asn Ser Leu Thr Gly
             180                 185                 190        
 Thr Asn His Ser Ile Gly Ser Ala Asp Pro Cys His Pro Glu Gln Pro
         195                 200                 205            
 His Leu Pro Ala Ala Asp Ser Thr Glu Ser Leu Ser Asp His Arg Gly
     210                 215                 220                
 Gly Ala Ser Asn Thr Thr Asp Ala Gln Val Asp Ser Ile Val Asp Pro
 225                 230                 235                 240
 Met Leu Asp Leu Asp Ile Gln Glu Leu Ala Ser Leu Thr Thr Gly Gly
                 245                 250                 255    
 Gly Asp Val Glu Asn Phe Glu Arg Leu Phe Ser Lys Leu Lys Glu Met
             260                 265                 270        
 Lys Asp Lys Ala Ala Thr Leu Pro His Glu Gln Arg Lys Val His Ala
         275                 280                 285            
 Glu Lys Val Ala Lys Ala Phe Trp Met Ala Ile Gly Gly Asp Arg Asp
     290                 295                 300                
 Glu Ile Glu Gly Leu Ser Ser Asp Glu Glu His
 305                 310                 315



      <210> 267
      <211> 285
      <212> PRT
      <213> Homo sapiens


      <400> 267
 Met Pro Arg Tyr Ala Gln Leu Val Met Gly Pro Ala Gly Ser Gly Lys
   1               5                  10                  15    
 Ser Thr Tyr Cys Ala Thr Met Val Gln His Cys Glu Ala Leu Asn Arg
              20                  25                  30        
 Ser Val Gln Val Val Asn Leu Asp Pro Ala Ala Glu His Phe Asn Tyr
          35                  40                  45            
 Ser Val Met Ala Asp Ile Arg Glu Leu Ile Glu Val Asp Asp Val Met
      50                  55                  60                
 Glu Asp Asp Ser Leu Arg Phe Gly Pro Asn Gly Gly Leu Val Phe Cys
  65                  70                  75                  80
 Met Glu Tyr Phe Ala Asn Asn Phe Asp Trp Leu Glu Asn Cys Leu Gly
                  85                  90                  95    
 His Val Glu Asp Asp Tyr Ile Leu Phe Asp Cys Pro Gly Gln Ile Glu
             100                 105                 110        
 Leu Tyr Thr His Leu Pro Val Met Lys Gln Leu Val Gln Gln Leu Glu
         115                 120                 125            
 Gln Trp Glu Phe Arg Val Cys Gly Val Phe Leu Val Asp Ser Gln Phe
     130                 135                 140                
 Met Val Glu Ser Phe Lys Phe Ile Ser Gly Ile Leu Ala Ala Leu Ser
 145                 150                 155                 160
 Ala Met Ile Ser Leu Glu Ile Pro Gln Val Asn Ile Met Thr Lys Met
                 165                 170                 175    
 Asp Leu Leu Ser Lys Lys Ala Lys Lys Glu Ile Glu Lys Phe Leu Asp
             180                 185                 190        
 Pro Asp Met Tyr Ser Leu Leu Glu Asp Ser Thr Ser Asp Leu Arg Ser
         195                 200                 205            
 Lys Lys Phe Lys Lys Leu Thr Lys Ala Ile Cys Gly Leu Ile Asp Asp
     210                 215                 220                
 Tyr Ser Met Val Arg Phe Leu Pro Tyr Asp Gln Ser Asp Glu Glu Ser
 225                 230                 235                 240
 Met Asn Ile Val Leu Gln His Ile Asp Phe Ala Ile Gln Tyr Gly Glu
                 245                 250                 255    
 Asp Leu Glu Phe Lys Glu Pro Lys Glu Arg Glu Asp Glu Ser Ser Ser
             260                 265                 270        
 Met Phe Asp Glu Tyr Phe Gln Glu Cys Gln Asp Glu
         275                 280                



      <210> 268
      <211> 219
      <212> PRT
      <213> Homo sapiens


      <400> 268
 Met Ser Cys Pro Asn Tyr Cys Ser Gly Asn Ser Asn Ser Gly Ser Leu
   1               5                  10                  15    
 Arg Thr Ser Arg His Ile Pro Leu Thr Ser Ile Asp Leu Cys Pro Thr
              20                  25                  30        
 Ser Val Ser Cys Gly Asp Val Leu Tyr Leu Pro Thr Ser Ser Gln Asp
          35                  40                  45            
 His Thr Trp Val Thr Asp Asn Cys Gln Glu Thr Cys Gly Glu Pro Thr
      50                  55                  60                
 Ser Cys Gln Pro Val His Cys Glu Thr Gly Asn Leu Glu Thr Ser Cys
  65                  70                  75                  80
 Gly Ser Ser Thr Ala Tyr Tyr Val Pro Arg Pro Cys Gln Gly Ser Ser
                  85                  90                  95    
 Phe Leu Pro Ala Ser Phe Phe Ser Ser Ser Cys Leu Pro Val Ser Cys
             100                 105                 110        
 Arg Pro Gln Arg Tyr Val Ser Ser Gly Cys Arg Pro Leu Arg Pro Leu
         115                 120                 125            
 Leu Asn Ser Tyr Gln Pro Ile Gly Arg Leu Cys Ala Gln Cys Leu Ser
     130                 135                 140                
 Pro Pro Ile Leu Leu Val Gln Glu Leu Pro Ala Pro Lys Pro Pro His
 145                 150                 155                 160
 Phe Trp Met Pro Thr Leu Glu Leu Leu Gly Leu Ser Ser Ser Lys Ser
                 165                 170                 175    
 Ser Arg Cys Val Gln Gln Pro Gln Thr Ser Gly Asp Ser Val Gln Trp
             180                 185                 190        
 Leu Pro Thr Ser Asp Pro Cys Val Gln His Val Ser Ser Ile Leu Leu
         195                 200                 205            
 Trp Thr Val Lys Pro Ala Ala Ser Leu Phe Gln
     210                 215                



      <210> 269
      <211> 635
      <212> PRT
      <213> Homo sapiens


      <400> 269
 Met Ala Met Trp Asn Arg Pro Cys Gln Arg Leu Pro Gln Gln Pro Leu
   1               5                  10                  15    
 Val Ala Glu Pro Thr Ala Glu Gly Glu Pro His Leu Pro Thr Gly Arg
              20                  25                  30        
 Glu Leu Thr Glu Ala Asn Arg Phe Ala Tyr Ala Ala Leu Cys Gly Ile
          35                  40                  45            
 Ser Leu Ser Gln Leu Phe Pro Glu Pro Glu His Ser Ser Phe Cys Thr
      50                  55                  60                
 Glu Phe Met Ala Gly Leu Val Gln Trp Leu Glu Leu Ser Glu Ala Val
  65                  70                  75                  80
 Leu Pro Thr Met Thr Ala Phe Ala Ser Gly Leu Gly Gly Glu Gly Ala
                  85                  90                  95    
 Asp Val Phe Val Gln Ile Leu Leu Lys Asp Pro Ile Leu Lys Asp Asp
             100                 105                 110        
 Pro Thr Val Ile Thr Gln Asp Leu Leu Ser Phe Ser Leu Lys Asp Gly
         115                 120                 125            
 His Tyr Asp Ala Arg Ala Arg Val Leu Val Cys His Met Thr Ser Leu
     130                 135                 140                
 Leu Gln Val Pro Leu Glu Glu Leu Asp Val Leu Glu Glu Met Phe Leu
 145                 150                 155                 160
 Glu Ser Leu Lys Glu Ile Lys Glu Glu Glu Ser Glu Met Ala Glu Ala
                 165                 170                 175    
 Ser Arg Lys Lys Lys Glu Asn Arg Arg Lys Trp Lys Arg Tyr Leu Leu
             180                 185                 190        
 Ile Gly Leu Ala Thr Val Gly Gly Gly Thr Val Ile Gly Val Thr Gly
         195                 200                 205            
 Gly Leu Ala Ala Pro Leu Val Ala Ala Gly Ala Ala Thr Ile Ile Gly
     210                 215                 220                
 Ser Ala Gly Ala Ala Ala Leu Gly Ser Ala Ala Gly Ile Ala Ile Met
 225                 230                 235                 240
 Thr Ser Leu Phe Gly Ala Ala Gly Ala Gly Leu Thr Gly Tyr Lys Met
                 245                 250                 255    
 Lys Lys Arg Val Gly Ala Ile Glu Glu Phe Thr Phe Leu Pro Leu Thr
             260                 265                 270        
 Glu Gly Arg Gln Leu His Ile Thr Ile Ala Val Thr Gly Trp Leu Ala
         275                 280                 285            
 Ser Gly Lys Tyr Arg Thr Phe Ser Ala Pro Trp Ala Ala Leu Ala His
     290                 295                 300                
 Ser Arg Glu Gln Tyr Cys Leu Ala Trp Glu Ala Lys Tyr Leu Met Glu
 305                 310                 315                 320
 Leu Gly Asn Ala Leu Glu Thr Ile Leu Ser Gly Leu Ala Asn Met Val
                 325                 330                 335    
 Ala Gln Glu Ala Leu Lys Tyr Thr Val Leu Ser Gly Ile Val Ala Ala
             340                 345                 350        
 Leu Thr Trp Pro Ala Ser Leu Leu Ser Val Ala Asn Val Ile Asp Asn
         355                 360                 365            
 Pro Trp Gly Val Cys Leu His Arg Ser Ala Glu Val Gly Lys His Leu
     370                 375                 380                
 Ala His Ile Leu Leu Ser Arg Gln Gln Gly Arg Arg Pro Val Thr Leu
 385                 390                 395                 400
 Ile Gly Phe Ser Leu Gly Ala Arg Val Ile Tyr Phe Cys Leu Gln Glu
                 405                 410                 415    
 Met Ala Gln Glu Lys Asp Cys Gln Gly Ile Ile Glu Asp Val Ile Leu
             420                 425                 430        
 Leu Gly Ala Pro Val Glu Gly Glu Ala Lys His Trp Glu Pro Phe Arg
         435                 440                 445            
 Lys Val Val Ser Gly Arg Ile Ile Asn Gly Tyr Cys Arg Gly Asp Trp
     450                 455                 460                
 Leu Leu Ser Phe Val Tyr Arg Thr Ser Ser Val Gln Leu His Val Ala
 465                 470                 475                 480
 Gly Leu Gln Pro Val Leu Leu Gln Asp Arg Arg Val Glu Asn Val Asp
                 485                 490                 495    
 Leu Thr Ser Val Val Ser Gly His Leu Asp Tyr Ala Lys Gln Met Asp
             500                 505                 510        
 Ala Ile Leu Lys Ala Val Gly Ile Arg Thr Lys Pro Gly Trp Asp Glu
         515                 520                 525            
 Lys Gly Leu Leu Leu Ala Pro Gly Cys Leu Pro Ser Glu Glu Pro Arg
     530                 535                 540                
 Gln Ala Ala Ala Ala Ala Ser Ser Gly Glu Thr Pro His Gln Val Gly
 545                 550                 555                 560
 Gln Thr Gln Gly Pro Ile Ser Gly Asp Thr Ser Lys Leu Ala Met Ser
                 565                 570                 575    
 Thr Asp Pro Ser Gln Ala Gln Val Pro Val Gly Leu Asp Gln Ser Glu
             580                 585                 590        
 Gly Ala Ser Leu Pro Ala Ala Ala Ser Pro Glu Arg Pro Pro Ile Cys
         595                 600                 605            
 Ser His Gly Met Asp Pro Asn Pro Leu Gly Cys Pro Asp Cys Ala Cys
     610                 615                 620                
 Lys Thr Gln Gly Pro Ser Thr Gly Leu Asp
 625                 630                



      <210> 270
      <211> 285
      <212> PRT
      <213> Homo sapiens


      <400> 270
 Met Ala Ala Pro Gly Leu Arg Leu Gly Ala Gly Arg Leu Phe Glu Met
   1               5                  10                  15    
 Pro Ala Val Leu Glu Arg Leu Ser Arg Tyr Asn Ser Thr Ser Gln Ala
              20                  25                  30        
 Phe Ala Glu Val Leu Arg Leu Pro Lys Gln Gln Leu Arg Lys Leu Leu
          35                  40                  45            
 Tyr Pro Leu Gln Glu Val Glu Arg Phe Leu Ala Pro Tyr Gly Arg Gln
      50                  55                  60                
 Asp Leu His Leu Arg Ile Phe Asp Pro Ser Pro Glu Asp Ile Ala Arg
  65                  70                  75                  80
 Ala Asp Asn Ile Phe Thr Ala Thr Glu Arg Asn Arg Ile Asp Tyr Val
                  85                  90                  95    
 Ser Ser Ala Val Arg Ile Asp His Ala Pro Asp Leu Pro Arg Pro Glu
             100                 105                 110        
 Val Cys Phe Ile Gly Arg Ser Asn Val Gly Lys Ser Ser Leu Ile Lys
         115                 120                 125            
 Ala Leu Phe Ser Leu Ala Pro Glu Val Glu Val Arg Val Ser Lys Lys
     130                 135                 140                
 Pro Gly His Thr Lys Lys Met Asn Phe Phe Lys Val Gly Lys His Phe
 145                 150                 155                 160
 Thr Val Val Asp Met Pro Gly Tyr Gly Phe Arg Ala Pro Glu Asp Phe
                 165                 170                 175    
 Val Asp Met Val Glu Thr Tyr Leu Lys Glu Arg Arg Asn Leu Lys Arg
             180                 185                 190        
 Thr Phe Leu Leu Val Asp Ser Val Val Gly Ile Gln Lys Thr Asp Asn
         195                 200                 205            
 Ile Ala Ile Glu Met Cys Glu Glu Phe Ala Leu Pro Tyr Val Ile Val
     210                 215                 220                
 Leu Thr Lys Ile Asp Lys Ser Ser Lys Gly His Leu Leu Lys Gln Val
 225                 230                 235                 240
 Leu Gln Ile Gln Lys Phe Val Asn Met Lys Thr Gln Gly Cys Phe Pro
                 245                 250                 255    
 Gln Leu Phe Pro Val Ser Ala Val Thr Phe Ser Gly Ile His Leu Leu
             260                 265                 270        
 Arg Cys Phe Ile Ala Ser Val Thr Gly Ser Leu Asp
         275                 280                



      <210> 271
      <211> 252
      <212> PRT
      <213> Homo sapiens


      <400> 271
 Met Ala Glu Thr Ala Val Ile Asn His Lys Lys Arg Lys Asn Ser Pro
   1               5                  10                  15    
 Arg Ile Val Gln Ser Asn Asp Leu Thr Glu Ala Ala Tyr Ser Leu Ser
              20                  25                  30        
 Arg Asp Gln Lys Arg Met Leu Tyr Leu Phe Val Asp Gln Ile Arg Lys
          35                  40                  45            
 Ser Asp Gly Thr Leu Gln Glu His Asp Gly Ile Cys Glu Ile His Val
      50                  55                  60                
 Ala Lys Tyr Ala Glu Ile Phe Gly Leu Thr Ser Ala Glu Ala Ser Lys
  65                  70                  75                  80
 Asp Ile Arg Gln Ala Leu Lys Ser Phe Ala Gly Lys Glu Val Val Phe
                  85                  90                  95    
 Tyr Arg Pro Glu Glu Asp Ala Gly Asp Glu Lys Gly Tyr Glu Ser Phe
             100                 105                 110        
 Pro Trp Phe Ile Lys Arg Ala His Ser Pro Ser Arg Gly Leu Tyr Ser
         115                 120                 125            
 Val His Ile Asn Pro Tyr Leu Ile Pro Phe Phe Ile Gly Leu Gln Asn
     130                 135                 140                
 Arg Phe Thr Gln Phe Arg Leu Ser Glu Thr Lys Glu Ile Thr Asn Pro
 145                 150                 155                 160
 Tyr Ala Met Arg Leu Tyr Glu Ser Leu Cys Gln Tyr Arg Lys Pro Asp
                 165                 170                 175    
 Gly Ser Gly Ile Val Ser Leu Lys Ile Asp Trp Ile Ile Glu Arg Tyr
             180                 185                 190        
 Gln Leu Pro Gln Ser Tyr Gln Arg Met Pro Asp Phe Arg Arg Arg Phe
         195                 200                 205            
 Leu Gln Val Cys Val Asn Glu Ile Asn Ser Arg Thr Pro Met Arg Leu
     210                 215                 220                
 Ser Tyr Ile Glu Lys Lys Lys Gly Arg Gln Thr Thr His Asn Ala Phe
 225                 230                 235                 240
 Ser Phe Arg Asp Ile Thr Ser Met Thr Thr Gly
                 245                 250    



      <210> 272
      <211> 252
      <212> PRT
      <213> Homo sapiens


      <400> 272
 Met Ala Glu Thr Ala Val Ile Asn His Lys Lys Arg Lys Asn Ser Pro
   1               5                  10                  15    
 Arg Ile Val Gln Ser Asn Asp Leu Thr Glu Ala Ala Tyr Ser Leu Ser
              20                  25                  30        
 Arg Asp Gln Lys Arg Met Leu Tyr Leu Phe Val Asp Gln Ile Arg Lys
          35                  40                  45            
 Ser Asp Gly Thr Leu Gln Glu His Asp Gly Ile Cys Glu Ile His Val
      50                  55                  60                
 Ala Lys Tyr Ala Glu Ile Phe Gly Leu Thr Ser Ala Glu Ala Ser Lys
  65                  70                  75                  80
 Asp Ile Arg Gln Ala Leu Lys Ser Phe Ala Gly Lys Glu Val Val Phe
                  85                  90                  95    
 Tyr Arg Pro Glu Glu Asp Ala Gly Asp Glu Lys Gly Tyr Glu Ser Phe
             100                 105                 110        
 Pro Trp Phe Ile Lys Arg Ala His Ser Pro Ser Arg Gly Leu Tyr Ser
         115                 120                 125            
 Val His Ile Asn Pro Tyr Leu Ile Pro Phe Phe Ile Gly Leu Gln Asn
     130                 135                 140                
 Arg Phe Thr Gln Phe Arg Leu Ser Glu Thr Lys Glu Ile Thr Asn Pro
 145                 150                 155                 160
 Tyr Ala Met Arg Leu Tyr Glu Ser Leu Cys Gln Tyr Arg Lys Pro Asp
                 165                 170                 175    
 Gly Ser Gly Ile Val Ser Leu Lys Ile Asp Trp Ile Ile Glu Arg Tyr
             180                 185                 190        
 Gln Leu Pro Gln Ser Tyr Gln Arg Met Pro Asp Phe Arg Arg Arg Phe
         195                 200                 205            
 Leu Gln Val Cys Val Asn Glu Ile Asn Ser Arg Thr Pro Met Arg Leu
     210                 215                 220                
 Ser Tyr Ile Glu Lys Lys Lys Gly Arg Gln Thr Thr His Ile Val Phe
 225                 230                 235                 240
 Ser Phe Arg Asp Ile Thr Ser Met Thr Thr Gly
                 245                 250    



      <210> 273
      <211> 877
      <212> PRT
      <213> Homo sapiens


      <400> 273
 Met Ala Ser Asp Ala Ser His Ala Leu Glu Ala Ala Leu Glu Gln Met
   1               5                  10                  15    
 Asp Gly Ile Ile Ala Gly Thr Lys Thr Gly Ala Asp Leu Ser Asp Gly
              20                  25                  30        
 Thr Cys Glu Pro Gly Leu Ala Ser Pro Ala Ser Tyr Met Asn Pro Phe
          35                  40                  45            
 Pro Val Leu His Leu Ile Glu Asp Leu Arg Leu Ala Leu Glu Met Leu
      50                  55                  60                
 Glu Leu Pro Gln Glu Arg Ala Ala Leu Leu Ser Gln Ile Pro Gly Pro
  65                  70                  75                  80
 Thr Ala Ala Tyr Ile Lys Glu Trp Phe Glu Glu Ser Leu Ser Gln Val
                  85                  90                  95    
 Asn His His Ser Ala Ala Ser Asn Glu Thr Tyr Gln Glu Arg Leu Ala
             100                 105                 110        
 Arg Leu Glu Gly Asp Lys Glu Ser Leu Ile Leu Gln Val Ser Val Leu
         115                 120                 125            
 Thr Asp Gln Val Glu Ala Gln Gly Glu Lys Ile Arg Asp Leu Glu Val
     130                 135                 140                
 Cys Leu Glu Gly His Gln Val Lys Leu Asn Ala Ala Glu Glu Met Leu
 145                 150                 155                 160
 Gln Gln Glu Leu Leu Ser Arg Thr Ser Leu Glu Thr Gln Lys Leu Asp
                 165                 170                 175    
 Leu Met Thr Glu Val Ser Glu Leu Lys Leu Lys Leu Val Gly Met Glu
             180                 185                 190        
 Lys Glu Gln Arg Glu Gln Glu Glu Lys Gln Arg Lys Ala Glu Glu Leu
         195                 200                 205            
 Leu Gln Glu Leu Arg His Leu Lys Ile Lys Val Glu Glu Leu Glu Asn
     210                 215                 220                
 Glu Arg Asn Gln Tyr Glu Trp Lys Leu Lys Ala Thr Lys Ala Glu Val
 225                 230                 235                 240
 Ala Gln Leu Gln Glu Gln Val Ala Leu Lys Asp Ala Glu Ile Glu Arg
                 245                 250                 255    
 Leu His Ser Gln Leu Ser Arg Thr Ala Ala Leu His Ser Glu Ser His
             260                 265                 270        
 Thr Glu Arg Asp Gln Glu Ile Gln Arg Leu Lys Met Gly Met Glu Thr
         275                 280                 285            
 Leu Leu Leu Ala Asn Glu Asp Lys Asp Arg Arg Ile Glu Glu Leu Thr
     290                 295                 300                
 Gly Leu Leu Asn Gln Tyr Arg Lys Val Lys Glu Ile Val Met Val Thr
 305                 310                 315                 320
 Gln Gly Pro Ser Glu Arg Thr Leu Ser Ile Asn Glu Glu Glu Pro Glu
                 325                 330                 335    
 Gly Gly Phe Ser Lys Trp Asn Ala Thr Asn Lys Asp Pro Glu Glu Leu
             340                 345                 350        
 Phe Lys Gln Glu Met Pro Pro Arg Cys Ser Ser Pro Thr Val Gly Pro
         355                 360                 365            
 Pro Pro Leu Pro Gln Lys Ser Leu Glu Thr Arg Ala Gln Lys Lys Leu
     370                 375                 380                
 Ser Cys Ser Leu Glu Asp Leu Arg Ser Glu Ser Val Asp Lys Cys Met
 385                 390                 395                 400
 Asp Gly Asn Gln Pro Phe Pro Val Leu Glu Pro Lys Asp Ser Pro Phe
                 405                 410                 415    
 Leu Ala Glu His Lys Tyr Pro Thr Leu Pro Gly Lys Leu Ser Gly Ala
             420                 425                 430        
 Thr Pro Asn Gly Glu Ala Ala Lys Ser Pro Pro Thr Ile Cys Gln Pro
         435                 440                 445            
 Asp Ala Thr Gly Ser Ser Leu Leu Arg Leu Arg Asp Thr Glu Ser Gly
     450                 455                 460                
 Trp Asp Asp Thr Ala Val Val Asn Asp Leu Ser Ser Thr Ser Ser Gly
 465                 470                 475                 480
 Thr Glu Ser Gly Pro Gln Ser Pro Leu Thr Pro Asp Gly Lys Arg Asn
                 485                 490                 495    
 Pro Lys Gly Ile Lys Lys Phe Trp Gly Lys Ile Arg Arg Thr Gln Ser
             500                 505                 510        
 Gly Asn Phe Tyr Thr Asp Thr Leu Gly Met Ala Glu Phe Arg Arg Gly
         515                 520                 525            
 Gly Leu Arg Ala Thr Ala Gly Pro Arg Leu Ser Arg Thr Arg Asp Ser
     530                 535                 540                
 Lys Gly Gln Lys Ser Asp Ala Asn Ala Pro Phe Ala Gln Trp Ser Thr
 545                 550                 555                 560
 Glu Arg Val Cys Ala Trp Leu Glu Asp Phe Gly Leu Ala Gln Tyr Val
                 565                 570                 575    
 Ile Phe Ala Arg Gln Trp Val Ser Ser Gly His Thr Leu Leu Thr Ala
             580                 585                 590        
 Thr Pro Gln Asp Met Glu Lys Glu Leu Gly Ile Lys His Pro Leu His
         595                 600                 605            
 Arg Lys Lys Leu Val Leu Ala Val Lys Ala Ile Asn Thr Lys Gln Glu
     610                 615                 620                
 Glu Lys Ser Ala Leu Leu Asp His Ile Trp Val Thr Arg Trp Leu Asp
 625                 630                 635                 640
 Asp Ile Gly Leu Pro Gln Tyr Lys Asp Gln Phe His Glu Ser Arg Val
                 645                 650                 655    
 Asp Gly Arg Met Leu Gln Tyr Leu Thr Val Asn Asp Leu Leu Phe Leu
             660                 665                 670        
 Lys Val Thr Ser Gln Leu His His Leu Ser Ile Lys Cys Ala Ile His
         675                 680                 685            
 Val Leu His Val Asn Lys Phe Asn Pro His Cys Leu His Leu Arg Pro
     690                 695                 700                
 Ala Asp Glu Ser Asn Leu Ser Pro Ser Glu Val Val Gln Trp Ser Asn
 705                 710                 715                 720
 His Arg Val Met Glu Trp Leu Arg Ser Val Asp Leu Ala Glu Tyr Ala
                 725                 730                 735    
 Pro Asn Leu Arg Gly Ser Gly Val His Gly Gly Leu Ile Ile Leu Glu
             740                 745                 750        
 Pro Arg Phe Thr Gly Asp Thr Leu Ala Met Leu Leu Asn Ile Pro Pro
         755                 760                 765            
 Gln Lys Thr Leu Leu Arg Arg His Leu Thr Thr Lys Phe Asn Ala Leu
     770                 775                 780                
 Ile Gly Pro Glu Ala Glu Gln Glu Lys Arg Glu Lys Met Ala Ser Pro
 785                 790                 795                 800
 Ala Tyr Thr Pro Leu Thr Thr Thr Ala Lys Val Arg Pro Arg Lys Leu
                 805                 810                 815    
 Gly Phe Ser His Phe Gly Asn Ile Arg Lys Lys Lys Phe Asp Glu Ser
             820                 825                 830        
 Thr Asp Tyr Ile Cys Pro Met Glu Pro Ser Asp Gly Val Ser Asp Ser
         835                 840                 845            
 His Arg Val Tyr Ser Gly Tyr Arg Gly Leu Ser Pro Leu Asp Ala Pro
     850                 855                 860                
 Glu Leu Asp Gly Leu Asp Gln Val Gly Gln Ile Ser
 865                 870                 875    



      <210> 274
      <211> 982
      <212> PRT
      <213> Homo sapiens


      <400> 274
 Met Gly Cys Arg Ser Pro Asp Leu Ala Ser Lys Asp Ser Tyr Tyr Leu
   1               5                  10                  15    
 Lys Gly Gly Arg Glu Ala Gln Ser Pro Trp Ala Tyr Gln Phe Leu Ser
              20                  25                  30        
 Lys Thr Gly Trp Ala Ala Asp Phe Trp Asn Ala Gly Met Ala His Ala
          35                  40                  45            
 Arg Asp Gly Cys Arg Gly Trp Gly Val Gly Cys Thr Ser Ile Ser Pro
      50                  55                  60                
 Thr Ala Glu Leu Gly Leu Val Leu Pro Gly Glu Leu Pro Ala Ala His
  65                  70                  75                  80
 Ile Ser Val Ala Leu Gln Ala Gln Gly Val Ser Lys Leu Pro Arg Lys
                  85                  90                  95    
 Val Met Ala Gly Arg Gly Leu Ser Ser Pro Arg Asp Arg Phe Ile Ser
             100                 105                 110        
 Asn Leu Ser Ile His Gln Gly Ala Ser Gln Gly Gln Arg Glu Gly Pro
         115                 120                 125            
 Pro Cys Ile Ala Ile Leu Ala Glu Leu Val Pro Ala Phe Leu Ala Leu
     130                 135                 140                
 Leu Phe Glu Gln Ala Val Gly Pro Val Pro Leu Ala Cys Cys Gln His
 145                 150                 155                 160
 Arg Leu Pro Thr Val Gly Leu Leu Ala Ala Gly Trp Gly Ser Ser Leu
                 165                 170                 175    
 Leu Gly Glu Ala Pro Trp Leu Gly Pro Glu Leu Trp Glu Thr Pro His
             180                 185                 190        
 Gln Leu Ala Gly Pro Leu Ala Asp Pro Ser Ser Lys Ser Gly Pro Glu
         195                 200                 205            
 Glu Leu Gln Ala Gln Ile Pro Ser Gly Val Leu Ala Gly Ala Leu Pro
     210                 215                 220                
 Glu Arg Ser Gly Phe Asp Pro Arg Ala Arg Arg Glu Glu Gly Ala Pro
 225                 230                 235                 240
 Leu Arg His Ser His Val His Glu Ala Pro Pro Gly Val Leu Glu Ser
                 245                 250                 255    
 Gly Gly Leu Arg Cys Asp Leu Asp Arg Asn Gln Leu Pro Arg Ala Thr
             260                 265                 270        
 Phe Ser His Gly Asn Met Cys Pro Gln Tyr Leu Ser Gln Ser Pro Asn
         275                 280                 285            
 Pro Ser Cys Pro Thr Ala Phe Ser Trp Asn Leu Pro Trp Ala Tyr Thr
     290                 295                 300                
 Ala Tyr Leu Ser Gly Met Leu Arg Phe Glu His Gln Glu Trp Lys Ala
 305                 310                 315                 320
 Ala Ile Glu Ala Phe Asn Lys Cys Lys Thr Ile Tyr Glu Lys Leu Ala
                 325                 330                 335    
 Ser Ala Phe Thr Glu Glu Gln Ala Val Leu Tyr Asn Gln Arg Val Glu
             340                 345                 350        
 Glu Ile Ser Pro Asn Ile Arg Tyr Cys Ala Tyr Asn Ile Gly Asp Gln
         355                 360                 365            
 Ser Ala Ile Asn Glu Leu Met Gln Met Arg Leu Arg Ser Gly Gly Thr
     370                 375                 380                
 Glu Gly Leu Leu Ala Glu Lys Leu Glu Ala Leu Ile Thr Gln Thr Arg
 385                 390                 395                 400
 Ala Lys Gln Ala Ala Thr Met Ser Glu Val Glu Trp Arg Gly Arg Thr
                 405                 410                 415    
 Val Pro Val Lys Ile Asp Lys Val Arg Ile Phe Leu Leu Gly Leu Ala
             420                 425                 430        
 Asp Asn Glu Ala Ala Ile Val Gln Ala Glu Ser Glu Glu Thr Lys Glu
         435                 440                 445            
 Arg Leu Phe Glu Ser Met Leu Ser Glu Cys Arg Asp Ala Ile Gln Val
     450                 455                 460                
 Val Arg Glu Glu Leu Lys Pro Asp Gln Lys Gln Arg Asp Tyr Ile Leu
 465                 470                 475                 480
 Glu Gly Glu Pro Gly Lys Val Ser Asn Leu Gln Tyr Leu His Ser Tyr
                 485                 490                 495    
 Leu Thr Tyr Ile Lys Leu Ser Thr Ala Ile Lys Arg Asn Glu Asn Met
             500                 505                 510        
 Ala Lys Gly Leu Gln Arg Ala Leu Leu Gln Gln Gln Pro Glu Asp Asp
         515                 520                 525            
 Ser Lys Arg Ser Pro Arg Pro Gln Asp Leu Ile Arg Leu Tyr Asp Ile
     530                 535                 540                
 Ile Leu Gln Asn Leu Val Glu Leu Leu Gln Leu Pro Gly Leu Glu Glu
 545                 550                 555                 560
 Asp Lys Ala Phe Gln Lys Glu Ile Gly Leu Lys Thr Leu Val Phe Lys
                 565                 570                 575    
 Ala Tyr Arg Cys Phe Phe Ile Ala Gln Ser Tyr Val Leu Val Lys Lys
             580                 585                 590        
 Trp Ser Glu Ala Leu Val Leu Tyr Asp Arg Val Leu Lys Tyr Ala Asn
         595                 600                 605            
 Glu Val Asn Ser Asp Ala Gly Ala Phe Lys Asn Ser Leu Lys Glu Ala
     610                 615                 620                
 Ser Ala Arg Arg Arg Glu Ile Glu Asp Lys Leu Lys Gln Glu Glu Glu
 625                 630                 635                 640
 Thr Leu Ser Phe Ile Arg Asp Ser Leu Glu Lys Ser Asp Gln Leu Thr
                 645                 650                 655    
 Lys Asn Met Gly Arg Leu Glu Lys His Lys Val Ser Ile Leu Ser Ser
             660                 665                 670        
 Phe Glu Ser Arg Leu Met Lys Leu Glu Asn Ser Ile Ile Pro Val His
         675                 680                 685            
 Lys Gln Thr Glu Asn Leu Gln Arg Leu Gln Glu Asn Val Glu Lys Thr
     690                 695                 700                
 Leu Ser Cys Leu Asp His Val Ile Ser Tyr Tyr His Val Ala Ser Asp
 705                 710                 715                 720
 Thr Glu Lys Ile Ile Arg Glu Gly Pro Thr Gly Arg Leu Glu Glu Tyr
                 725                 730                 735    
 Leu Gly Ser Met Ala Lys Ile Gln Lys Ala Val Glu Tyr Phe Gln Asp
             740                 745                 750        
 Asn Ser Pro Asp Ser Pro Glu Leu Asn Lys Val Lys Leu Leu Phe Glu
         755                 760                 765            
 Arg Gly Lys Glu Ala Leu Glu Ser Glu Phe Arg Ser Leu Met Thr Arg
     770                 775                 780                
 His Ser Lys Val Val Ser Pro Val Leu Ile Leu Asp Leu Ile Ser Gly
 785                 790                 795                 800
 Asp Asp Asp Leu Glu Ala Gln Glu Asp Val Thr Leu Glu His Leu Pro
                 805                 810                 815    
 Glu Ser Val Leu Gln Asp Val Ile Arg Ile Ser Arg Trp Leu Val Glu
             820                 825                 830        
 Tyr Gly Arg Asn Gln Asp Phe Met Asn Val Tyr Tyr Gln Ile Arg Ser
         835                 840                 845            
 Ser Gln Leu Asp Arg Ser Ile Lys Gly Leu Lys Glu His Phe His Lys
     850                 855                 860                
 Ser Ser Ser Ser Ser Gly Val Pro Tyr Ser Pro Ala Ile Pro Asn Lys
 865                 870                 875                 880
 Arg Lys Asp Thr Pro Thr Lys Lys Pro Val Lys Arg Pro Gly Thr Ile
                 885                 890                 895    
 Arg Lys Ala Gln Asn Leu Leu Lys Gln Tyr Ser Gln His Gly Leu Asp
             900                 905                 910        
 Gly Lys Lys Gly Gly Ser Asn Leu Ile Pro Leu Glu Gly Arg Asp Asp
         915                 920                 925            
 Met Leu Asp Val Glu Thr Asp Ala Tyr Ile His Cys Arg Gln Cys Leu
     930                 935                 940                
 Arg Gln Ala Gly Ala Glu Arg Val Pro Ala Ala Gly Arg His His Pro
 945                 950                 955                 960
 Arg Ala Pro Pro Glu Glu Asp Leu Arg Leu Pro Asp Thr Gly Cys Pro
                 965                 970                 975    
 Gly Trp Ala Asp Ala
             980    



      <210> 275
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 275
 Met Cys Trp Glu Pro Ile Val Leu Gly Arg Ser Trp Ile Ala Ile Lys
   1               5                  10                  15    
 Lys Tyr Leu Arg Leu Gly Asn Leu Val Phe Trp Phe Phe Gly Val Phe
              20                  25                  30        
 Phe Glu Thr Glu Pro Cys Ser Val Ala Gln Ala Gly Val Gln Trp Arg
          35                  40                  45            
 Asp Leu Gly Ser Met Gln Pro Pro Pro Pro Gly Phe Met Pro Phe Ser
      50                  55                  60                
 Cys Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg Arg Pro Pro Pro Cys
  65                  70                  75                  80
 Leu Ala Asn Phe Leu Tyr Phe
                  85        



      <210> 276
      <211> 82
      <212> PRT
      <213> Homo sapiens


      <400> 276
 Met Met Phe Pro Leu Ala Arg Asn Ala Leu Ser Ser Leu Lys Ile Gln
   1               5                  10                  15    
 Ser Ile Leu Gln Ser Met Ala Arg His Ser His Val Lys His Ser Pro
              20                  25                  30        
 Asp Phe His Asp Lys Tyr Gly Asn Ala Val Leu Ala Ser Gly Thr Ala
          35                  40                  45            
 Phe Cys Val Ala Thr Trp Val Phe Thr Ala Thr Gln Ile Gly Ile Glu
      50                  55                  60                
 Trp Asn Leu Ser Pro Val Gly Arg Val Thr Pro Lys Glu Trp Lys His
  65                  70                  75                  80
 Gln
    



      <210> 277
      <211> 271
      <212> PRT
      <213> Homo sapiens


      <400> 277
 Met Ala Thr Gly Thr Arg Tyr Ala Gly Lys Val Val Val Val Thr Gly
   1               5                  10                  15    
 Gly Gly Arg Gly Ile Gly Ala Gly Ile Val Arg Ala Phe Val Asn Ser
              20                  25                  30        
 Gly Ala Arg Val Val Ile Cys Asp Lys Asp Glu Ser Gly Gly Arg Ala
          35                  40                  45            
 Leu Glu Gln Glu Leu Pro Gly Ala Val Phe Ile Leu Cys Asp Val Thr
      50                  55                  60                
 Gln Glu Asp Asp Val Lys Thr Leu Val Ser Glu Thr Ile Arg Arg Phe
  65                  70                  75                  80
 Gly Arg Leu Asp Cys Val Val Asn Asn Ala Gly His His Pro Pro Pro
                  85                  90                  95    
 Gln Arg Pro Glu Glu Thr Ser Ala Gln Gly Phe Arg Gln Leu Leu Glu
             100                 105                 110        
 Leu Asn Leu Leu Gly Thr Tyr Thr Leu Thr Lys Leu Ala Leu Pro Tyr
         115                 120                 125            
 Leu Arg Lys Ser Gln Gly Asn Val Ile Asn Ile Ser Ser Leu Val Gly
     130                 135                 140                
 Ala Ile Gly Gln Ala Gln Ala Val Pro Tyr Val Ala Thr Lys Gly Ala
 145                 150                 155                 160
 Val Thr Ala Met Thr Lys Ala Leu Ala Leu Asp Glu Ser Pro Tyr Gly
                 165                 170                 175    
 Val Arg Val Asn Cys Ile Ser Pro Gly Asn Ile Trp Thr Pro Leu Trp
             180                 185                 190        
 Glu Glu Leu Ala Ala Leu Met Pro Asp Pro Arg Ala Thr Ile Arg Glu
         195                 200                 205            
 Gly Met Leu Ala Gln Pro Leu Gly Arg Met Gly Gln Pro Ala Glu Val
     210                 215                 220                
 Gly Ala Ala Ala Val Phe Leu Ala Ser Glu Ala Asn Phe Cys Thr Gly
 225                 230                 235                 240
 Ile Glu Leu Leu Val Thr Gly Gly Ala Glu Leu Gly Tyr Gly Cys Lys
                 245                 250                 255    
 Ala Ser Arg Ser Thr Pro Val Asp Ala Pro Asp Ile Pro Ser
             260                 265                 270



      <210> 278
      <211> 78
      <212> PRT
      <213> Homo sapiens


      <400> 278
 Met Gly Phe His His Val Cys Gln Ala Gly Leu Glu Leu Leu Thr Ser
   1               5                  10                  15    
 Gly Asp Pro Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Met
              20                  25                  30        
 Ser His His Ala Gln Pro Asn His Gly Leu Leu Phe Pro Ser Leu Gln
          35                  40                  45            
 Thr Tyr Gln Asn Leu Lys Lys Arg Leu Asp Ile Thr Trp Ala Leu Val
      50                  55                  60                
 Pro Val Ser Ile Leu Met Ile Thr Ala Gly Leu Ser Ser
  65                  70                  75        



      <210> 279
      <211> 262
      <212> PRT
      <213> Homo sapiens


      <400> 279
 Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly
   1               5                  10                  15    
 Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Pro
              20                  25                  30        
 Cys Cys Asp Lys Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu
          35                  40                  45            
 Asp His Gln Leu Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn
      50                  55                  60                
 Cys Glu Lys Ile Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr
  65                  70                  75                  80
 Leu Phe Gly Glu Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp
                  85                  90                  95    
 Lys Lys Gln Tyr His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro
             100                 105                 110        
 Lys Glu Asp Phe Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met
         115                 120                 125            
 Asn Leu Gln Gly Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn
     130                 135                 140                
 Cys Pro Ile Cys Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His
 145                 150                 155                 160
 Val Leu Pro Cys Gly His Leu Leu His Arg Thr Cys Tyr Glu Glu Met
                 165                 170                 175    
 Leu Lys Glu Gly Tyr Arg Cys Pro Leu Cys Met His Ser Ala Leu Asp
             180                 185                 190        
 Met Thr Arg Tyr Trp Arg Gln Leu Asp Asp Glu Val Ala Gln Thr Pro
         195                 200                 205            
 Met Pro Ser Glu Tyr Gln Asn Met Thr Val Asp Ile Leu Cys Asn Asp
     210                 215                 220                
 Cys Asn Gly Arg Ser Thr Val Gln Phe His Ile Leu Gly Met Lys Cys
 225                 230                 235                 240
 Lys Ile Cys Glu Ser Tyr Asn Thr Ala Gln Ala Gly Gly Arg Arg Ile
                 245                 250                 255    
 Ser Leu Asp Gln Gln
             260    



      <210> 280
      <211> 192
      <212> PRT
      <213> Homo sapiens


      <400> 280
 Met Glu Leu Lys Asn Leu Glu Tyr Arg Pro Val Lys Val Arg Gly Cys
   1               5                  10                  15    
 Phe Asp His Ser Lys Glu Leu Tyr Met Met Pro Arg Thr Met Val Asp
              20                  25                  30        
 Pro Val Arg Glu Ala Arg Glu Gly Gly Leu Ile Ser Ser Ser Thr Gln
          35                  40                  45            
 Ser Gly Ala Tyr Val Val Thr Pro Phe His Cys Thr Asp Leu Gly Val
      50                  55                  60                
 Thr Ile Leu Val Asn Arg Gly Phe Val Pro Arg Lys Lys Val Asn Pro
  65                  70                  75                  80
 Glu Thr Arg Gln Lys Gly Gln Ile Glu Gly Glu Val Asp Leu Ile Gly
                  85                  90                  95    
 Met Val Arg Leu Thr Glu Thr Arg Gln Pro Phe Val Pro Glu Asn Asn
             100                 105                 110        
 Pro Glu Arg Asn His Trp His Tyr Arg Asp Leu Glu Ala Met Ala Arg
         115                 120                 125            
 Ile Thr Gly Ala Glu Pro Ile Phe Ile Asp Ala Asn Phe Gln Ser Thr
     130                 135                 140                
 Val Pro Gly Gly Pro Ile Gly Gly Gln Thr Arg Val Thr Leu Arg Asn
 145                 150                 155                 160
 Glu His Leu Gln Tyr Ile Val Thr Trp Tyr Gly Leu Ser Ala Ala Thr
                 165                 170                 175    
 Ser Tyr Leu Trp Phe Lys Lys Phe Leu Arg Gly Thr Pro Gly Val
             180                 185                 190    



      <210> 281
      <211> 353
      <212> PRT
      <213> Homo sapiens


      <400> 281
 Met Arg Ser Leu Gly Ala Leu Leu Leu Leu Leu Ser Ala Cys Leu Ala
   1               5                  10                  15    
 Val Ser Ala Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln
              20                  25                  30        
 Glu Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala
          35                  40                  45            
 Ile Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr
      50                  55                  60                
 Val Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser
  65                  70                  75                  80
 Met Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly
                  85                  90                  95    
 Ala Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser
             100                 105                 110        
 Lys Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp
         115                 120                 125            
 Glu Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro
     130                 135                 140                
 Thr Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr
 145                 150                 155                 160
 Leu Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu
                 165                 170                 175    
 Asp Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu
             180                 185                 190        
 Gln Glu Pro Glu Pro Ile Leu Ile Pro Arg Val Arg Arg Ala Val Leu
         195                 200                 205            
 Pro Gln Glu Glu Glu Gly Ser Gly Gly Gly Gln Leu Val Thr Glu Val
     210                 215                 220                
 Thr Lys Lys Glu Asp Ser Cys Gln Leu Gly Tyr Ser Ala Gly Pro Cys
 225                 230                 235                 240
 Met Gly Met Thr Ser Arg Tyr Phe Tyr Asn Gly Thr Ser Met Ala Cys
                 245                 250                 255    
 Glu Thr Phe Gln Tyr Gly Gly Cys Met Gly Asn Gly Asn Asn Phe Val
             260                 265                 270        
 Thr Glu Lys Glu Cys Leu Gln Thr Cys Arg Thr Val Ala Ala Cys Asn
         275                 280                 285            
 Leu Pro Ile Val Arg Gly Pro Cys Arg Ala Phe Ile Gln Leu Trp Ala
     290                 295                 300                
 Phe Asp Ala Val Lys Gly Lys Cys Val Leu Phe Pro Tyr Gly Gly Cys
 305                 310                 315                 320
 Gln Gly Asn Gly Asn Lys Phe Tyr Ser Glu Lys Glu Cys Arg Glu Tyr
                 325                 330                 335    
 Cys Gly Val Pro Gly Asp Gly Asp Glu Glu Leu Leu Arg Phe Ser Asn
             340                 345                 350        





      <210> 282
      <211> 727
      <212> PRT
      <213> Homo sapiens


      <400> 282
 Met Ala Asp Ser Ser Gly Gln Gln Gly Lys Gly Arg Arg Val Gln Pro
   1               5                  10                  15    
 Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu His Leu Tyr
              20                  25                  30        
 Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile Pro Gln Asp Gly Lys
          35                  40                  45            
 Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp Ala Ser His
      50                  55                  60                
 Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu Arg Arg Val
  65                  70                  75                  80
 Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met Asn Ile Thr
                  85                  90                  95    
 Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn His Leu Phe
             100                 105                 110        
 Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu Leu Glu Asp
         115                 120                 125            
 Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn Glu Thr Thr
     130                 135                 140                
 Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His Ala Val Gln
 145                 150                 155                 160
 Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg Leu Thr Gly
                 165                 170                 175    
 Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu Ala Lys Asp
             180                 185                 190        
 Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp Val Thr Asp
         195                 200                 205            
 Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly Asp Phe His
     210                 215                 220                
 Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val Leu Thr Arg
 225                 230                 235                 240
 Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln Lys Ile Val
                 245                 250                 255    
 Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr Phe Asp Thr
             260                 265                 270        
 Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly Lys Leu Val Pro
         275                 280                 285            
 Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu Gly Asp Leu
     290                 295                 300                
 Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro Asn Asp Phe
 305                 310                 315                 320
 Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp Pro Cys Pro
                 325                 330                 335    
 Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu Cys Ser Ala Met Ala
             340                 345                 350        
 Gly Thr Leu Leu Gly Ala Ser Met Asp Ile His Gly Gly Gly Phe Asp
         355                 360                 365            
 Leu Arg Phe Pro His His Asp Asn Glu Leu Ala Gln Ser Glu Ala Tyr
     370                 375                 380                
 Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe Leu His Thr Gly His Leu
 385                 390                 395                 400
 Thr Ile Ala Gly Cys Lys Met Ser Lys Ser Leu Lys Asn Phe Ile Thr
                 405                 410                 415    
 Ile Lys Asp Ala Leu Lys Lys His Ser Ala Arg Gln Leu Arg Leu Ala
             420                 425                 430        
 Phe Leu Met His Ser Trp Lys Asp Thr Leu Asp Tyr Ser Ser Asn Thr
         435                 440                 445            
 Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe Leu Asn Glu Phe Phe Leu
     450                 455                 460                
 Asn Val Lys Asp Ile Leu Arg Ala Pro Val Asp Ile Thr Gly Gln Phe
 465                 470                 475                 480
 Glu Lys Trp Gly Glu Glu Glu Ala Glu Leu Asn Lys Asn Phe Tyr Asp
                 485                 490                 495    
 Lys Lys Thr Ala Ile His Lys Ala Leu Cys Asp Asn Val Asp Thr Arg
             500                 505                 510        
 Thr Val Met Glu Glu Met Arg Ala Leu Val Ser Gln Cys Asn Leu Tyr
         515                 520                 525            
 Met Ala Ala Arg Lys Ala Val Arg Lys Arg Pro Asn Gln Ala Leu Leu
     530                 535                 540                
 Glu Asn Ile Ala Leu Tyr Leu Thr His Met Leu Lys Ile Phe Gly Ala
 545                 550                 555                 560
 Val Glu Glu Asp Ser Ser Leu Gly Phe Pro Val Gly Gly Pro Gly Thr
                 565                 570                 575    
 Ser Leu Ser Leu Glu Ala Thr Val Met Pro Tyr Leu Gln Val Leu Ser
             580                 585                 590        
 Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Gln Lys Val Pro
         595                 600                 605            
 Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile Leu Pro Glu
     610                 615                 620                
 Leu Gly Val Arg Phe Glu Asp His Glu Gly Leu Pro Thr Val Val Lys
 625                 630                 635                 640
 Leu Val Asp Arg Asn Thr Leu Leu Lys Glu Arg Glu Glu Lys Arg Arg
                 645                 650                 655    
 Val Glu Glu Glu Lys Arg Lys Lys Lys Glu Glu Ala Ala Arg Arg Lys
             660                 665                 670        
 Gln Glu Gln Glu Ala Ala Lys Leu Ala Lys Met Lys Ile Pro Pro Ser
         675                 680                 685            
 Glu Met Phe Leu Ser Glu Thr Asp Lys Tyr Ser Lys Phe Asp Glu Asn
     690                 695                 700                
 Val Ser Met Val Cys Pro His Met Thr Trp Arg Ala Lys Ser Ser Ala
 705                 710                 715                 720
 Lys Gly Lys Pro Arg Ser
                 725    



      <210> 283
      <211> 184
      <212> PRT
      <213> Homo sapiens


      <400> 283
 Met Ala Ser Asn Lys Thr Thr Leu Gln Lys Met Gly Lys Lys Gln Asn
   1               5                  10                  15    
 Gly Lys Ser Lys Lys Val Glu Glu Ala Glu Pro Glu Glu Phe Val Val
              20                  25                  30        
 Glu Lys Val Leu Asp Arg Arg Val Val Asn Gly Lys Val Glu Tyr Phe
          35                  40                  45            
 Leu Lys Trp Lys Gly Phe Thr Asp Ala Asp Asn Thr Trp Glu Pro Glu
      50                  55                  60                
 Glu Asn Leu Asp Cys Pro Glu Leu Ile Glu Ala Phe Leu Asn Ser Gln
  65                  70                  75                  80
 Lys Ala Gly Lys Glu Lys Asp Gly Thr Lys Arg Lys Ser Leu Ser Asp
                  85                  90                  95    
 Ser Glu Ser Asp Asp Ser Lys Ser Lys Lys Lys Arg Asp Ala Ala Asp
             100                 105                 110        
 Lys Pro Arg Gly Phe Ala Arg Gly Leu Asp Pro Glu Arg Ile Ile Gly
         115                 120                 125            
 Ala Thr Asp Ser Ser Gly Glu Leu Met Phe Leu Met Lys Trp Lys Asp
     130                 135                 140                
 Ser Asp Glu Ala Asp Leu Val Leu Ala Lys Glu Ala Asn Met Lys Cys
 145                 150                 155                 160
 Pro Gln Ile Val Ile Ala Phe Tyr Glu Glu Arg Leu Thr Trp His Ser
                 165                 170                 175    
 Cys Pro Glu Asp Glu Ala Gln
             180            



      <210> 284
      <211> 373
      <212> PRT
      <213> Homo sapiens


      <400> 284
 Met Ala Thr Ser Pro Gln Lys Ser Pro Ser Val Pro Lys Ser Pro Thr
   1               5                  10                  15    
 Pro Lys Ser Pro Pro Ser Arg Lys Lys Asp Asp Ser Phe Leu Gly Lys
              20                  25                  30        
 Leu Gly Gly Thr Leu Ala Arg Arg Lys Lys Ala Lys Glu Val Ser Glu
          35                  40                  45            
 Leu Gln Glu Glu Gly Met Asn Ala Ile Asn Leu Pro Leu Ser Pro Ile
      50                  55                  60                
 Pro Phe Glu Leu Asp Pro Glu Asp Thr Met Leu Glu Glu Asn Glu Val
  65                  70                  75                  80
 Arg Thr Met Val Asp Pro Asn Ser Arg Ser Asp Pro Lys Leu Gln Glu
                  85                  90                  95    
 Leu Met Lys Val Leu Ile Asp Trp Ile Asn Asp Val Leu Val Gly Glu
             100                 105                 110        
 Arg Ile Ile Val Lys Asp Leu Ala Glu Asp Leu Tyr Asp Gly Gln Val
         115                 120                 125            
 Leu Gln Lys Leu Phe Glu Lys Leu Glu Ser Glu Lys Leu Asn Val Ala
     130                 135                 140                
 Glu Val Thr Gln Ser Glu Ile Ala Gln Lys Gln Lys Leu Gln Thr Val
 145                 150                 155                 160
 Leu Glu Lys Ile Asn Glu Thr Leu Lys Leu Pro Pro Arg Ser Ile Lys
                 165                 170                 175    
 Trp Asn Val Asp Ser Val His Ala Lys Ser Leu Val Ala Ile Leu His
             180                 185                 190        
 Leu Leu Val Ala Leu Ser Gln Tyr Phe Arg Ala Pro Ile Arg Leu Pro
         195                 200                 205            
 Asp His Val Ser Ile Gln Val Val Val Val Gln Lys Arg Glu Gly Ile
     210                 215                 220                
 Leu Gln Ser Arg Gln Ile Gln Glu Glu Ile Thr Gly Asn Thr Glu Ala
 225                 230                 235                 240
 Leu Ser Gly Arg His Glu Arg Asp Ala Phe Asp Thr Leu Phe Asp His
                 245                 250                 255    
 Ala Pro Asp Lys Leu Asn Val Val Lys Lys Thr Leu Ile Thr Phe Val
             260                 265                 270        
 Asn Lys His Leu Asn Lys Leu Asn Leu Glu Val Thr Glu Leu Glu Thr
         275                 280                 285            
 Gln Phe Ala Asp Gly Val Tyr Leu Val Leu Leu Met Gly Leu Leu Glu
     290                 295                 300                
 Gly Tyr Phe Val Pro Leu His Ser Phe Phe Leu Thr Pro Asp Ser Phe
 305                 310                 315                 320
 Glu Gln Lys Val Leu Asn Val Ser Phe Ala Phe Glu Leu Met Gln Asp
                 325                 330                 335    
 Gly Gly Leu Glu Lys Pro Lys Pro Arg Pro Glu Asp Ile Val Asn Cys
             340                 345                 350        
 Asp Leu Lys Ser Thr Leu Arg Val Leu Tyr Asn Leu Phe Thr Lys Tyr
         355                 360                 365            
 Arg Asn Val Glu
     370        



      <210> 285
      <211> 216
      <212> PRT
      <213> Homo sapiens


      <400> 285
 Met Lys Lys Val Arg Leu Lys Glu Leu Glu Ser Arg Leu Gln Gln Val
   1               5                  10                  15    
 Asp Gly Phe Glu Lys Pro Lys Leu Leu Leu Glu Gln Tyr Pro Thr Arg
              20                  25                  30        
 Pro His Ile Ala Ala Cys Met Leu Tyr Thr Ile His Asn Thr Tyr Asp
          35                  40                  45            
 Asp Ile Glu Asn Lys Val Val Ala Asp Leu Gly Cys Gly Cys Gly Val
      50                  55                  60                
 Leu Ser Ile Gly Thr Ala Met Leu Gly Ala Gly Leu Cys Val Gly Phe
  65                  70                  75                  80
 Asp Ile Asp Glu Asp Ala Leu Glu Ile Phe Asn Arg Asn Ala Glu Glu
                  85                  90                  95    
 Phe Glu Leu Thr Asn Ile Asp Met Val Gln Cys Asp Val Cys Leu Leu
             100                 105                 110        
 Ser Asn Arg Met Ser Lys Ser Phe Asp Thr Val Ile Met Asn Pro Pro
         115                 120                 125            
 Phe Gly Thr Lys Asn Asn Lys Gly Thr Asp Met Ala Phe Leu Lys Thr
     130                 135                 140                
 Ala Leu Glu Met Ala Arg Thr Ala Val Tyr Ser Leu His Lys Ser Ser
 145                 150                 155                 160
 Thr Arg Glu His Val Gln Lys Lys Ala Ala Glu Trp Lys Ile Lys Ile
                 165                 170                 175    
 Asp Ile Ile Ala Gly Gly Phe Cys Phe Thr Glu Leu Arg Tyr Asp Leu
             180                 185                 190        
 Pro Ala Ser Tyr Lys Phe His Lys Lys Lys Ser Val Asp Ile Glu Val
         195                 200                 205            
 Asp Leu Ile Arg Phe Ser Phe
     210                 215



      <210> 286
      <211> 148
      <212> PRT
      <213> Homo sapiens


      <400> 286
 Met Gly Glu Pro Gln Gly Ser Met Arg Ile Leu Val Thr Gly Gly Ser
   1               5                  10                  15    
 Gly Leu Val Gly Lys Ala Ile Gln Lys Val Val Ala Asp Gly Ala Gly
              20                  25                  30        
 Leu Pro Gly Glu Asp Trp Val Phe Val Ser Ser Lys Asp Ala Asp Leu
          35                  40                  45            
 Thr Asp Thr Ala Gln Thr Arg Ala Leu Phe Glu Lys Val Gln Pro Thr
      50                  55                  60                
 His Ile Ile Leu Ser Val Gly Glu Glu Asp Glu Val Ser Ile Lys Glu
  65                  70                  75                  80
 Ala Ala Glu Ala Val Val Glu Ala Met Asp Phe His Gly Glu Val Thr
                  85                  90                  95    
 Phe Asp Thr Thr Lys Ser Asp Gly Gln Phe Lys Lys Thr Ala Ser Asn
             100                 105                 110        
 Ser Lys Leu Arg Thr Tyr Leu Pro Asp Phe Arg Phe Thr Pro Phe Lys
         115                 120                 125            
 Gln Ala Val Lys Glu Thr Cys Ala Trp Phe Thr Asp Asn Tyr Glu Gln
     130                 135                 140                
 Ala Arg Lys
 145        



      <210> 287
      <211> 782
      <212> PRT
      <213> Homo sapiens


      <400> 287
 Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro
   1               5                  10                  15    
 Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp
              20                  25                  30        
 Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly
          35                  40                  45            
 Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr
      50                  55                  60                
 Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala
  65                  70                  75                  80
 Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala
                  85                  90                  95    
 Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr
             100                 105                 110        
 Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro
         115                 120                 125            
 Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp
     130                 135                 140                
 Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu
 145                 150                 155                 160
 Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His
                 165                 170                 175    
 Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro
             180                 185                 190        
 Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val
         195                 200                 205            
 Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His
     210                 215                 220                
 Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu
 225                 230                 235                 240
 Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile
                 245                 250                 255    
 Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala
             260                 265                 270        
 Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys
         275                 280                 285            
 Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu
     290                 295                 300                
 Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly
 305                 310                 315                 320
 Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu
                 325                 330                 335    
 Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser
             340                 345                 350        
 Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu
         355                 360                 365            
 His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr
     370                 375                 380                
 Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly
 385                 390                 395                 400
 Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val
                 405                 410                 415    
 Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr
             420                 425                 430        
 Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val
         435                 440                 445            
 Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala
     450                 455                 460                
 Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met
 465                 470                 475                 480
 Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys
                 485                 490                 495    
 Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly
             500                 505                 510        
 Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg
         515                 520                 525            
 Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His
     530                 535                 540                
 Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe
 545                 550                 555                 560
 Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala
                 565                 570                 575    
 Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly
             580                 585                 590        
 Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu
         595                 600                 605            
 Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp
     610                 615                 620                
 Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu
 625                 630                 635                 640
 Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala
                 645                 650                 655    
 Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys
             660                 665                 670        
 Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met
         675                 680                 685            
 Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly
     690                 695                 700                
 Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His
 705                 710                 715                 720
 Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu
                 725                 730                 735    
 His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly
             740                 745                 750        
 Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro
         755                 760                 765            
 Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu
     770                 775                 780    



      <210> 288
      <211> 1152
      <212> PRT
      <213> Homo sapiens


      <400> 288
 Met Leu Arg Arg Val Thr Val Ala Ala Val Cys Ala Thr Arg Arg Lys
   1               5                  10                  15    
 Leu Cys Glu Ala Gly Arg Glu Leu Ala Ala Leu Trp Gly Ile Glu Thr
              20                  25                  30        
 Arg Gly Arg Cys Glu Asp Ser Ala Ala Ala Arg Pro Phe Pro Ile Leu
          35                  40                  45            
 Ala Met Pro Gly Arg Asn Lys Ala Lys Ser Thr Cys Ser Cys Pro Asp
      50                  55                  60                
 Leu Gln Pro Asn Gly Gln Asp Leu Gly Glu Asn Ser Arg Val Ala Arg
  65                  70                  75                  80
 Leu Gly Ala Asp Glu Ser Glu Glu Glu Gly Arg Arg Gly Ser Leu Ser
                  85                  90                  95    
 Asn Ala Gly Asp Pro Glu Ile Val Lys Ser Pro Ser Asp Pro Lys Gln
             100                 105                 110        
 Tyr Arg Tyr Ile Lys Leu Gln Asn Gly Leu Gln Ala Leu Leu Ile Ser
         115                 120                 125            
 Asp Leu Ser Asn Met Glu Gly Lys Thr Gly Asn Thr Thr Asp Asp Glu
     130                 135                 140                
 Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Asp Asp Asp Glu Asp Ser
 145                 150                 155                 160
 Gly Ala Glu Ile Glu Asp Asp Asp Glu Glu Gly Phe Asp Asp Glu Asp
                 165                 170                 175    
 Glu Phe Asp Asp Glu His Asp Asp Asp Leu Asp Thr Glu Asp Asn Glu
             180                 185                 190        
 Leu Glu Glu Leu Glu Glu Arg Ala Glu Ala Arg Lys Lys Thr Thr Glu
         195                 200                 205            
 Lys Gln Ser Ala Ala Ala Leu Cys Val Gly Val Gly Ser Phe Ala Asp
     210                 215                 220                
 Pro Asp Asp Leu Pro Gly Leu Ala His Phe Leu Glu His Met Val Phe
 225                 230                 235                 240
 Met Gly Ser Leu Lys Tyr Pro Asp Glu Asn Gly Phe Asp Ala Phe Leu
                 245                 250                 255    
 Lys Lys His Gly Gly Ser Asp Asn Ala Ser Thr Asp Cys Glu Arg Thr
             260                 265                 270        
 Val Phe Gln Phe Asp Val Gln Arg Lys Tyr Phe Lys Glu Ala Leu Asp
         275                 280                 285            
 Arg Trp Ala Gln Phe Phe Ile His Pro Leu Met Ile Arg Asp Ala Ile
     290                 295                 300                
 Asp Arg Glu Val Glu Ala Val Asp Ser Glu Tyr Gln Leu Ala Arg Pro
 305                 310                 315                 320
 Ser Asp Ala Asn Arg Lys Glu Met Leu Phe Gly Ser Leu Ala Arg Pro
                 325                 330                 335    
 Gly His Pro Met Gly Lys Phe Phe Trp Gly Asn Ala Glu Thr Leu Lys
             340                 345                 350        
 His Glu Pro Arg Lys Asn Asn Ile Asp Thr His Ala Arg Leu Arg Glu
         355                 360                 365            
 Phe Trp Met Arg Tyr Tyr Ser Ser His Tyr Met Thr Leu Val Val Gln
     370                 375                 380                
 Ser Lys Glu Thr Leu Asp Thr Leu Glu Lys Trp Val Thr Glu Ile Phe
 385                 390                 395                 400
 Ser Gln Ile Pro Asn Asn Gly Leu Pro Arg Pro Asn Phe Gly His Leu
                 405                 410                 415    
 Thr Asp Pro Phe Asp Thr Pro Ala Phe Asn Lys Leu Tyr Arg Val Val
             420                 425                 430        
 Pro Ile Arg Lys Ile His Ala Leu Thr Ile Thr Trp Ala Leu Pro Pro
         435                 440                 445            
 Gln Gln Gln His Tyr Arg Val Lys Pro Leu His Tyr Ile Ser Trp Leu
     450                 455                 460                
 Val Gly His Glu Gly Lys Gly Ser Ile Leu Ser Phe Leu Arg Lys Lys
 465                 470                 475                 480
 Cys Trp Ala Leu Ala Leu Phe Gly Gly Asn Gly Glu Thr Gly Phe Glu
                 485                 490                 495    
 Gln Asn Ser Thr Tyr Ser Val Phe Ser Ile Ser Ile Thr Leu Thr Asp
             500                 505                 510        
 Glu Gly Tyr Glu His Phe Tyr Glu Val Ala Tyr Thr Val Phe Gln Tyr
         515                 520                 525            
 Leu Lys Met Leu Gln Lys Leu Gly Pro Glu Lys Arg Ile Phe Glu Glu
     530                 535                 540                
 Ile Arg Lys Ile Glu Asp Asn Glu Phe His Tyr Gln Glu Gln Thr Asp
 545                 550                 555                 560
 Pro Val Glu Tyr Val Glu Asn Met Cys Glu Asn Met Gln Leu Tyr Pro
                 565                 570                 575    
 Leu Gln Asp Ile Leu Thr Gly Asp Gln Leu Leu Phe Glu Tyr Lys Pro
             580                 585                 590        
 Glu Val Ile Gly Glu Ala Leu Asn Gln Leu Val Pro Gln Lys Ala Asn
         595                 600                 605            
 Leu Val Leu Leu Ser Gly Ala Asn Glu Gly Lys Cys Asp Leu Lys Glu
     610                 615                 620                
 Lys Trp Phe Gly Thr Gln Tyr Ser Ile Glu Asp Ile Glu Asn Ser Trp
 625                 630                 635                 640
 Ala Glu Leu Trp Asn Ser Asn Phe Glu Leu Asn Pro Asp Leu His Leu
                 645                 650                 655    
 Pro Ala Glu Asn Lys Tyr Ile Ala Thr Asp Phe Thr Leu Lys Ala Phe
             660                 665                 670        
 Asp Cys Pro Glu Thr Glu Tyr Pro Val Lys Ile Val Asn Thr Pro Gln
         675                 680                 685            
 Gly Cys Leu Trp Tyr Lys Lys Asp Asn Lys Phe Lys Ile Pro Lys Ala
     690                 695                 700                
 Tyr Ile Arg Phe His Leu Ile Ser Pro Leu Ile Gln Lys Ser Ala Ala
 705                 710                 715                 720
 Asn Val Val Leu Phe Asp Ile Phe Val Asn Ile Leu Thr His Asn Leu
                 725                 730                 735    
 Ala Glu Pro Ala Tyr Glu Ala Asp Val Ala Gln Leu Glu Tyr Lys Leu
             740                 745                 750        
 Val Ala Gly Glu His Gly Leu Ile Ile Arg Val Lys Gly Phe Asn His
         755                 760                 765            
 Lys Leu Pro Leu Leu Phe Gln Leu Ile Ile Asp Tyr Leu Ala Glu Phe
     770                 775                 780                
 Asn Ser Thr Pro Ala Val Phe Thr Met Ile Thr Glu Gln Leu Lys Lys
 785                 790                 795                 800
 Thr Tyr Phe Asn Ile Leu Ile Lys Pro Glu Thr Leu Ala Lys Asp Val
                 805                 810                 815    
 Arg Leu Leu Ile Leu Glu Tyr Ala Arg Trp Ser Met Ile Asp Lys Tyr
             820                 825                 830        
 Gln Ala Leu Met Asp Gly Leu Ser Leu Glu Ser Leu Leu Ser Phe Val
         835                 840                 845            
 Lys Glu Phe Lys Ser Gln Leu Phe Val Glu Gly Leu Val Gln Gly Asn
     850                 855                 860                
 Val Thr Ser Thr Glu Ser Met Asp Phe Leu Lys Tyr Val Val Asp Lys
 865                 870                 875                 880
 Leu Asn Phe Lys Pro Leu Glu Gln Glu Met Pro Val Gln Phe Gln Val
                 885                 890                 895    
 Val Glu Leu Pro Ser Gly His His Leu Cys Lys Val Lys Ala Leu Asn
             900                 905                 910        
 Lys Gly Asp Ala Asn Ser Glu Val Thr Val Tyr Tyr Gln Ser Gly Thr
         915                 920                 925            
 Arg Ser Leu Arg Glu Tyr Thr Leu Met Glu Leu Leu Val Met His Met
     930                 935                 940                
 Glu Glu Pro Cys Phe Asp Phe Leu Arg Thr Lys Gln Thr Leu Gly Tyr
 945                 950                 955                 960
 His Val Tyr Pro Thr Cys Arg Asn Thr Ser Gly Ile Leu Gly Phe Ser
                 965                 970                 975    
 Val Thr Val Gly Thr Gln Ala Thr Lys Tyr Asn Ser Glu Val Val Asp
             980                 985                 990        
 Lys Lys Ile Glu Glu Phe Leu Ser Ser Phe Glu Glu Lys Ile Glu Asn
         995                1000                1005            
 Leu Thr Glu Glu Ala Phe Asn Thr Gln Val Thr Ala Leu Ile Lys Leu
    1010                1015                1020                
 Lys Glu Cys Glu Asp Thr His Leu Gly Glu Glu Val Asp Arg Asn Trp
1025                1030                1035                1040
 Asn Glu Val Val Thr Gln Gln Tyr Leu Phe Asp Arg Leu Ala His Glu
                1045                1050                1055    
 Ile Glu Ala Leu Lys Ser Phe Ser Lys Ser Asp Leu Val Asn Trp Phe
            1060                1065                1070        
 Lys Ala His Arg Gly Pro Gly Ser Lys Met Leu Ser Val His Val Val
        1075                1080                1085            
 Gly Tyr Gly Lys Tyr Glu Leu Glu Glu Asp Gly Thr Pro Ser Ser Glu
    1090                1095                1100                
 Asp Ser Asn Ser Ser Cys Glu Val Met Gln Leu Thr Tyr Leu Pro Thr
1105                1110                1115                1120
 Ser Pro Leu Leu Ala Asp Cys Ile Ile Pro Ile Thr Asp Ile Arg Ala
                1125                1130                1135    
 Phe Thr Thr Thr Leu Asn Leu Leu Pro Tyr His Lys Ile Val Lys
            1140                1145                1150    



      <210> 289
      <211> 1220
      <212> PRT
      <213> Homo sapiens


      <400> 289
 Met Leu Arg Arg Val Thr Val Ala Ala Val Cys Ala Thr Arg Arg Lys
   1               5                  10                  15    
 Leu Cys Glu Ala Gly Arg Glu Leu Ala Ala Leu Trp Gly Ile Glu Thr
              20                  25                  30        
 Arg Gly Arg Cys Glu Asp Ser Ala Ala Ala Arg Pro Phe Pro Ile Leu
          35                  40                  45            
 Ala Met Pro Gly Arg Asn Lys Ala Lys Ser Thr Cys Ser Cys Pro Asp
      50                  55                  60                
 Leu Gln Pro Asn Gly Gln Asp Leu Gly Glu Asn Ser Arg Val Ala Arg
  65                  70                  75                  80
 Leu Gly Ala Asp Glu Ser Glu Glu Glu Gly Arg Arg Gly Ser Leu Ser
                  85                  90                  95    
 Asn Ala Gly Asp Pro Glu Ile Val Lys Ser Pro Ser Asp Pro Lys Gln
             100                 105                 110        
 Tyr Arg Tyr Ile Lys Leu Gln Asn Gly Leu Gln Ala Leu Leu Ile Ser
         115                 120                 125            
 Asp Leu Ser Asn Met Glu Gly Lys Thr Gly Asn Thr Thr Asp Asp Glu
     130                 135                 140                
 Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Asp Asp Asp Glu Asp Ser
 145                 150                 155                 160
 Gly Ala Glu Ile Glu Asp Asp Asp Glu Glu Gly Phe Asp Asp Glu Asp
                 165                 170                 175    
 Glu Phe Asp Asp Glu His Asp Asp Asp Leu Asp Thr Glu Asp Asn Glu
             180                 185                 190        
 Leu Glu Glu Leu Glu Glu Arg Ala Glu Ala Arg Lys Lys Thr Thr Glu
         195                 200                 205            
 Lys Gln Gln Leu Gln Ser Leu Phe Leu Leu Trp Ser Lys Leu Thr Asp
     210                 215                 220                
 Arg Leu Trp Phe Lys Ser Thr Tyr Ser Lys Met Ser Ser Thr Leu Leu
 225                 230                 235                 240
 Val Glu Thr Arg Asn Leu Tyr Gly Val Val Gly Ala Glu Ser Arg Ser
                 245                 250                 255    
 Ala Pro Val Gln His Leu Ala Gly Trp Gln Ala Glu Glu Gln Gln Gly
             260                 265                 270        
 Glu Thr Asp Thr Val Leu Ser Ala Ala Ala Leu Cys Val Gly Val Gly
         275                 280                 285            
 Ser Phe Ala Asp Pro Asp Asp Leu Pro Gly Leu Ala His Phe Leu Glu
     290                 295                 300                
 His Met Val Phe Met Gly Ser Leu Lys Tyr Pro Asp Glu Asn Gly Phe
 305                 310                 315                 320
 Asp Ala Phe Leu Lys Lys His Gly Gly Ser Asp Asn Ala Ser Thr Asp
                 325                 330                 335    
 Cys Glu Arg Thr Val Phe Gln Phe Asp Val Gln Arg Lys Tyr Phe Lys
             340                 345                 350        
 Glu Ala Leu Asp Arg Trp Ala Gln Phe Phe Ile His Pro Leu Met Ile
         355                 360                 365            
 Arg Asp Ala Ile Asp Arg Glu Val Glu Ala Val Asp Ser Glu Tyr Gln
     370                 375                 380                
 Leu Ala Arg Pro Ser Asp Ala Asn Arg Lys Glu Met Leu Phe Gly Ser
 385                 390                 395                 400
 Leu Ala Arg Pro Gly His Pro Met Gly Lys Phe Phe Trp Gly Asn Ala
                 405                 410                 415    
 Glu Thr Leu Lys His Glu Pro Arg Lys Asn Asn Ile Asp Thr His Ala
             420                 425                 430        
 Arg Leu Arg Glu Phe Trp Met Arg Tyr Tyr Ser Ser His Tyr Met Thr
         435                 440                 445            
 Leu Val Val Gln Ser Lys Glu Thr Leu Asp Thr Leu Glu Lys Trp Val
     450                 455                 460                
 Thr Glu Ile Phe Ser Gln Ile Pro Asn Asn Gly Leu Pro Arg Pro Asn
 465                 470                 475                 480
 Phe Gly His Leu Thr Asp Pro Phe Asp Thr Pro Ala Phe Asn Lys Leu
                 485                 490                 495    
 Tyr Arg Val Val Pro Ile Arg Lys Ile His Ala Leu Thr Ile Thr Trp
             500                 505                 510        
 Ala Leu Pro Pro Gln Gln Gln His Tyr Arg Val Lys Pro Leu His Tyr
         515                 520                 525            
 Ile Ser Trp Leu Val Gly His Glu Gly Lys Gly Ser Ile Leu Ser Phe
     530                 535                 540                
 Leu Arg Lys Lys Cys Trp Ala Leu Ala Leu Phe Gly Gly Asn Gly Glu
 545                 550                 555                 560
 Thr Gly Phe Glu Gln Asn Ser Thr Tyr Ser Val Phe Ser Ile Ser Ile
                 565                 570                 575    
 Thr Leu Thr Asp Glu Gly Tyr Glu His Phe Tyr Glu Val Ala Tyr Thr
             580                 585                 590        
 Val Phe Gln Tyr Leu Lys Met Leu Gln Lys Leu Gly Pro Glu Lys Arg
         595                 600                 605            
 Ile Phe Glu Glu Ile Arg Lys Ile Glu Asp Asn Glu Phe His Tyr Gln
     610                 615                 620                
 Glu Gln Thr Asp Pro Val Glu Tyr Val Glu Asn Met Cys Glu Asn Met
 625                 630                 635                 640
 Gln Leu Tyr Pro Leu Gln Asp Ile Leu Thr Gly Asp Gln Leu Leu Phe
                 645                 650                 655    
 Glu Tyr Lys Pro Glu Val Ile Gly Glu Ala Leu Asn Gln Leu Val Pro
             660                 665                 670        
 Gln Lys Ala Asn Leu Val Leu Leu Ser Gly Ala Asn Glu Gly Lys Cys
         675                 680                 685            
 Asp Leu Lys Glu Lys Trp Phe Gly Thr Gln Tyr Ser Ile Glu Asp Ile
     690                 695                 700                
 Glu Asn Ser Trp Ala Glu Leu Trp Asn Ser Asn Phe Glu Leu Asn Pro
 705                 710                 715                 720
 Asp Leu His Leu Pro Ala Glu Asn Lys Tyr Ile Ala Thr Asp Phe Thr
                 725                 730                 735    
 Leu Lys Ala Phe Asp Cys Pro Glu Thr Glu Tyr Pro Val Lys Ile Val
             740                 745                 750        
 Asn Thr Pro Gln Gly Cys Leu Trp Tyr Lys Lys Asp Asn Lys Phe Lys
         755                 760                 765            
 Ile Pro Lys Ala Tyr Ile Arg Phe His Leu Ile Ser Pro Leu Ile Gln
     770                 775                 780                
 Lys Ser Ala Ala Asn Val Val Leu Phe Asp Ile Phe Val Asn Ile Leu
 785                 790                 795                 800
 Thr His Asn Leu Ala Glu Pro Ala Tyr Glu Ala Asp Val Ala Gln Leu
                 805                 810                 815    
 Glu Tyr Lys Leu Val Ala Gly Glu His Gly Leu Ile Ile Arg Val Lys
             820                 825                 830        
 Gly Phe Asn His Lys Leu Pro Leu Leu Phe Gln Leu Ile Ile Asp Tyr
         835                 840                 845            
 Leu Ala Glu Phe Asn Ser Thr Pro Ala Val Phe Thr Met Ile Thr Glu
     850                 855                 860                
 Gln Leu Lys Lys Thr Tyr Phe Asn Ile Leu Ile Lys Pro Glu Thr Leu
 865                 870                 875                 880
 Ala Lys Asp Val Arg Leu Leu Ile Leu Glu Tyr Ala Arg Trp Ser Met
                 885                 890                 895    
 Ile Asp Lys Tyr Gln Ala Leu Met Asp Gly Leu Ser Leu Glu Ser Leu
             900                 905                 910        
 Leu Ser Phe Val Lys Glu Phe Lys Ser Gln Leu Phe Val Glu Gly Leu
         915                 920                 925            
 Val Gln Gly Asn Val Thr Ser Thr Glu Ser Met Asp Phe Leu Lys Tyr
     930                 935                 940                
 Val Val Asp Lys Leu Asn Phe Lys Pro Leu Glu Gln Glu Met Pro Val
 945                 950                 955                 960
 Gln Phe Gln Val Val Glu Leu Pro Ser Gly His His Leu Cys Lys Val
                 965                 970                 975    
 Lys Ala Leu Asn Lys Gly Asp Ala Asn Ser Glu Val Thr Val Tyr Tyr
             980                 985                 990        
 Gln Ser Gly Thr Arg Ser Leu Arg Glu Tyr Thr Leu Met Glu Leu Leu
         995                1000                1005            
 Val Met His Met Glu Glu Pro Cys Phe Asp Phe Leu Arg Thr Lys Gln
    1010                1015                1020                
 Thr Leu Gly Tyr His Val Tyr Pro Thr Cys Arg Asn Thr Ser Gly Ile
1025                1030                1035                1040
 Leu Gly Phe Ser Val Thr Val Gly Thr Gln Ala Thr Lys Tyr Asn Ser
                1045                1050                1055    
 Glu Val Val Asp Lys Lys Ile Glu Glu Phe Leu Ser Ser Phe Glu Glu
            1060                1065                1070        
 Lys Ile Glu Asn Leu Thr Glu Glu Ala Phe Asn Thr Gln Val Thr Ala
        1075                1080                1085            
 Leu Ile Lys Leu Lys Glu Cys Glu Asp Thr His Leu Gly Glu Glu Val
    1090                1095                1100                
 Asp Arg Asn Trp Asn Glu Val Val Thr Gln Gln Tyr Leu Phe Asp Arg
1105                1110                1115                1120
 Leu Ala His Glu Ile Glu Ala Leu Lys Ser Phe Ser Lys Ser Asp Leu
                1125                1130                1135    
 Val Asn Trp Phe Lys Ala His Arg Gly Pro Gly Ser Lys Met Leu Ser
            1140                1145                1150        
 Val His Val Val Gly Tyr Gly Lys Tyr Glu Leu Glu Glu Asp Gly Thr
        1155                1160                1165            
 Pro Ser Ser Glu Asp Ser Asn Ser Ser Cys Glu Val Met Gln Leu Thr
    1170                1175                1180                
 Tyr Leu Pro Thr Ser Pro Leu Leu Ala Asp Cys Ile Ile Pro Ile Thr
1185                1190                1195                1200
 Asp Ile Arg Ala Phe Thr Thr Thr Leu Asn Leu Leu Pro Tyr His Lys
                1205                1210                1215    
 Ile Val Lys
            



      <210> 290
      <211> 173
      <212> PRT
      <213> Homo sapiens


      <400> 290
 Met Ser Ser Lys Arg Ala Lys Ala Lys Thr Thr Lys Lys Arg Pro Gln
   1               5                  10                  15    
 Arg Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile Gln
              20                  25                  30        
 Glu Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly Phe
          35                  40                  45            
 Ile Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu Gly Lys Asn
      50                  55                  60                
 Pro Thr Asp Glu Tyr Leu Glu Gly Met Met Ser Glu Ala Pro Gly Pro
  65                  70                  75                  80
 Ile Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys Leu Asn Gly
                  85                  90                  95    
 Thr Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Cys Phe Asp Glu
             100                 105                 110        
 Glu Ala Ser Gly Phe Ile His Glu Asp His Leu Arg Glu Leu Leu Thr
         115                 120                 125            
 Thr Met Gly Asp Arg Phe Thr Asp Glu Glu Val Asp Glu Met Tyr Arg
     130                 135                 140                
 Glu Ala Pro Ile Asp Lys Lys Gly Asn Phe Asn Tyr Val Glu Phe Thr
 145                 150                 155                 160
 Arg Ile Leu Lys His Gly Ala Lys Asp Lys Asp Asp
                 165                 170        



      <210> 291
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 291
 Met Trp Lys His Leu Pro Val His Ser Ser Pro Thr Pro Arg Leu Thr
   1               5                  10                  15    
 Pro Leu Trp Lys Leu Gln Ala Arg Trp Leu Leu Pro Gln Leu Val Tyr
              20                  25                  30        
 Leu Gln Gly Trp Gly Ser Tyr Ser Leu Leu Arg Pro Ala Ala Leu Ile
          35                  40                  45            
 Ser Met Val Leu Leu Ala Arg Glu Phe Leu Tyr Pro Ala Lys Met Ser
      50                  55                  60                
 Val Ser Glu Val Cys Ser Ser Gly Leu Ser Ser Pro Leu Leu Glu Gln
  65                  70                  75                  80
 His Lys Thr Asn Leu Ile Phe Tyr Ala Ser Gly Asp Ile Cys Ser Ala
                  85                  90                  95    
 Asn Gly Lys Ser Gly Phe Asn Gln Pro Leu Pro Phe Leu Lys Thr Phe
             100                 105                 110        
 Cys Ser Thr His Arg Ile Leu Ser Cys Thr Tyr Leu
         115                 120                



      <210> 292
      <211> 215
      <212> PRT
      <213> Homo sapiens


      <400> 292
 Met Val Ser Lys Ser Leu Trp Arg Lys Trp Glu Gln Lys Leu Asp Cys
   1               5                  10                  15    
 Glu Leu Lys Lys Gln Ile His Asn Tyr Pro Glu Cys Arg Ile Leu Gln
              20                  25                  30        
 Asp Glu Ile Cys Arg Thr Met Ser Trp Leu Glu Gln Leu Ile Ser Asp
          35                  40                  45            
 Cys His Thr Leu Thr Thr Glu Leu Ala Ser Pro Thr Leu Leu Thr Met
      50                  55                  60                
 Glu Met Asp Leu Arg Arg Leu Pro Gln Pro Ala Leu Ala Cys Glu Arg
  65                  70                  75                  80
 Gln Arg Ala Ala Tyr Lys Glu Glu Ser Trp Phe Gln Thr Ser Glu Gly
                  85                  90                  95    
 His Gly Gln Gln Thr Val Val Ser Pro Phe Leu Ala Leu Leu Thr Leu
             100                 105                 110        
 Glu Pro Thr Phe Arg His Leu Leu Arg Ile Met Gln Val Ser Thr Ala
         115                 120                 125            
 Ala Leu Ala Val Leu Leu Cys Thr Met Ala Leu Cys Asn Gln Phe Ser
     130                 135                 140                
 Ala Ser Leu Ala Ala Asp Thr Pro Thr Ala Cys Cys Phe Ser Tyr Thr
 145                 150                 155                 160
 Ser Arg Gln Ile Pro Gln Asn Phe Ile Ala Asp Tyr Phe Glu Thr Ser
                 165                 170                 175    
 Ser Gln Cys Ser Lys Pro Gly Val Ile Phe Leu Thr Lys Arg Ser Arg
             180                 185                 190        
 Gln Val Cys Ala Asp Pro Ser Glu Glu Trp Val Gln Lys Tyr Val Ser
         195                 200                 205            
 Asp Leu Glu Leu Ser Ala
     210                



      <210> 293
      <211> 93
      <212> PRT
      <213> Homo sapiens


      <400> 293
 Met Arg Val Thr Gly Thr Ala Val Gly Met Thr Val Thr Arg Lys Asp
   1               5                  10                  15    
 Lys Gly Ala Leu Leu Leu Val Ala Thr His Gln Phe Asp Lys Glu Cys
              20                  25                  30        
 Cys Glu Ile Phe Ile Tyr Leu Phe Ile Tyr Phe Glu Met Glu Phe His
          35                  40                  45            
 Ser Cys Cys Pro Gly Trp Ser Ala Val Val Gln Ser Arg Leu Thr Ala
      50                  55                  60                
 Thr Ser Thr Ser Gln Val Gln Ala Ile Leu Leu Pro Gln Pro Pro Lys
  65                  70                  75                  80
 Tyr Leu Gly Leu Gln Val Arg Ala Thr Thr Pro Ser
                  85                  90        



      <210> 294
      <211> 511
      <212> PRT
      <213> Homo sapiens


      <400> 294
 Met Ile Ser Pro Asp Pro Arg Pro Ser Pro Gly Leu Ala Arg Gly Ala
   1               5                  10                  15    
 Glu Ser Tyr Glu Ala Lys Cys Glu Arg Arg Gln Glu Ile Arg Glu Ser
              20                  25                  30        
 Arg Arg Cys Arg Pro Asn Val Thr Thr Cys Arg Gln Val Gly Lys Thr
          35                  40                  45            
 Leu Arg Ile Gln Gln Arg Glu Gln Leu Gln Arg Ala Arg Leu Gln Gln
      50                  55                  60                
 Phe Phe Arg Arg Arg Asn Leu Glu Leu Glu Glu Lys Gly Lys Ala Gln
  65                  70                  75                  80
 His Pro Gln Ala Arg Glu Gln Gly Pro Ser Arg Arg Pro Gly Gln Val
                  85                  90                  95    
 Thr Gly Thr Ser Ser Glu Val Phe Pro Ala Gln His Pro Pro Pro Ser
             100                 105                 110        
 Gly Ile Cys Arg Asp Leu Ser Asp His Leu Ser Ser Gln Ala Gly Gly
         115                 120                 125            
 Leu Pro Pro Gln Asp Thr Pro Ile Lys Lys Pro Pro Lys His His Arg
     130                 135                 140                
 Gly Thr Gln Thr Lys Ala Glu Gly Pro Thr Ile Lys Asn Asp Ala Ser
 145                 150                 155                 160
 Gln Gln Thr Asn Tyr Gly Val Ala Val Leu Asp Lys Glu Ile Ile Gln
                 165                 170                 175    
 Leu Ser Asp Tyr Leu Lys Glu Ala Leu Gln Arg Glu Leu Val Leu Lys
             180                 185                 190        
 Gln Lys Met Val Ile Leu Gln Asp Leu Leu Ser Thr Leu Ile Gln Ala
         195                 200                 205            
 Ser Asp Ser Ser Trp Lys Gly Gln Leu Asn Glu Asp Lys Leu Lys Gly
     210                 215                 220                
 Lys Leu Arg Ser Leu Glu Asn Gln Leu Tyr Thr Cys Thr Gln Lys Tyr
 225                 230                 235                 240
 Ser Pro Trp Gly Met Lys Lys Val Leu Leu Glu Met Glu Asp Gln Lys
                 245                 250                 255    
 Asn Ser Tyr Glu Gln Lys Ala Lys Glu Ser Leu Gln Lys Val Leu Glu
             260                 265                 270        
 Glu Lys Met Asn Ala Glu Gln Gln Leu Gln Ser Thr Gln Arg Ser Leu
         275                 280                 285            
 Ala Leu Ala Glu Gln Lys Cys Glu Glu Trp Arg Ser Gln Tyr Glu Ala
     290                 295                 300                
 Leu Lys Glu Asp Trp Arg Thr Leu Gly Thr Gln His Arg Glu Leu Glu
 305                 310                 315                 320
 Ser Gln Leu His Val Leu Gln Ser Lys Leu Gln Gly Ala Asp Ser Arg
                 325                 330                 335    
 Asp Leu Gln Met Asn Gln Ala Leu Arg Phe Leu Glu Asn Glu His Gln
             340                 345                 350        
 Gln Leu Gln Ala Lys Ile Glu Cys Leu Gln Gly Asp Arg Asp Leu Cys
         355                 360                 365            
 Ser Leu Asp Thr Gln Asp Leu Gln Asp Gln Leu Lys Arg Ser Glu Ala
     370                 375                 380                
 Glu Lys Leu Thr Leu Val Thr Arg Val Gln Gln Leu Gln Gly Leu Leu
 385                 390                 395                 400
 Gln Asn Gln Ser Leu Gln Leu Gln Glu Gln Glu Lys Leu Leu Thr Lys
                 405                 410                 415    
 Lys Asp Gln Ala Leu Pro Val Trp Ser Pro Lys Ser Phe Pro Asn Glu
             420                 425                 430        
 Val Glu Pro Glu Gly Thr Gly Lys Glu Lys Asp Trp Asp Leu Arg Asp
         435                 440                 445            
 Gln Leu Gln Lys Lys Thr Leu Gln Leu Gln Ala Lys Glu Lys Glu Cys
     450                 455                 460                
 Arg Glu Leu His Ser Glu Leu Asp Asn Leu Ser Asp Glu Tyr Leu Ser
 465                 470                 475                 480
 Cys Leu Arg Lys Leu Gln His Cys Arg Glu Glu Leu Asn Gln Ser Gln
                 485                 490                 495    
 Gln Leu Pro Pro Arg Arg Pro Met Trp Ala Lys Ala Ser Gln Cys
             500                 505                 510    



      <210> 295
      <211> 362
      <212> PRT
      <213> Homo sapiens


      <400> 295
 Met Val His Ala Glu Ala Phe Ser Arg Pro Leu Ser Arg Asn Glu Val
   1               5                  10                  15    
 Val Gly Leu Ile Phe Arg Leu Thr Ile Phe Gly Ala Val Thr Tyr Phe
              20                  25                  30        
 Thr Ile Lys Trp Met Val Asp Ala Ile Asp Pro Thr Arg Lys Gln Lys
          35                  40                  45            
 Val Glu Ala Gln Lys Gln Ala Glu Lys Leu Met Lys Gln Ile Gly Val
      50                  55                  60                
 Lys Asn Val Lys Leu Ser Glu Tyr Glu Met Ser Ile Ala Ala His Leu
  65                  70                  75                  80
 Val Asp Pro Leu Asn Met His Val Thr Trp Ser Asp Ile Ala Gly Leu
                  85                  90                  95    
 Asp Asp Val Ile Thr Asp Leu Lys Asp Thr Val Ile Leu Pro Ile Lys
             100                 105                 110        
 Lys Lys His Leu Phe Glu Asn Ser Arg Leu Leu Gln Pro Pro Lys Gly
         115                 120                 125            
 Val Leu Leu Tyr Gly Pro Pro Gly Cys Gly Lys Thr Leu Ile Ala Lys
     130                 135                 140                
 Ala Thr Ala Lys Glu Ala Gly Cys Arg Phe Ile Asn Leu Gln Pro Ser
 145                 150                 155                 160
 Thr Leu Thr Asp Lys Trp Tyr Gly Glu Ser Gln Lys Leu Ala Ala Ala
                 165                 170                 175    
 Val Phe Ser Leu Ala Ile Lys Leu Gln Pro Ser Ile Ile Phe Ile Asp
             180                 185                 190        
 Glu Ile Asp Ser Phe Leu Arg Asn Arg Ser Ser Ser Asp His Glu Ala
         195                 200                 205            
 Thr Ala Met Met Lys Ala Gln Phe Met Ser Leu Trp Asp Gly Leu Asp
     210                 215                 220                
 Thr Asp His Ser Cys Gln Val Ile Val Met Gly Ala Thr Asn Arg Pro
 225                 230                 235                 240
 Gln Asp Leu Asp Ser Ala Ile Met Arg Arg Met Pro Thr Arg Phe His
                 245                 250                 255    
 Ile Asn Gln Pro Ala Leu Lys Gln Arg Glu Ala Ile Leu Lys Leu Ile
             260                 265                 270        
 Leu Lys Asn Glu Asn Val Asp Arg His Val Asp Leu Leu Glu Val Ala
         275                 280                 285            
 Gln Glu Thr Asp Gly Phe Ser Gly Ser Asp Leu Lys Glu Met Cys Arg
     290                 295                 300                
 Asp Ala Ala Leu Leu Cys Val Arg Glu Tyr Val Asn Ser Thr Ser Glu
 305                 310                 315                 320
 Glu Ser His Asp Glu Asp Glu Ile Arg Pro Val Gln Gln Gln Asp Leu
                 325                 330                 335    
 His Arg Ala Ile Glu Lys Met Lys Lys Ser Lys Asp Ala Ala Phe Gln
             340                 345                 350        
 Asn Val Leu Thr His Val Cys Leu Asp
         355                 360    



      <210> 296
      <211> 294
      <212> PRT
      <213> Homo sapiens


      <400> 296
 Met Glu Arg Leu Thr Leu Thr Arg Thr Ile Gly Gly Pro Leu Leu Thr
   1               5                  10                  15    
 Ala Thr Leu Leu Gly Lys Thr Thr Ile Asn Asp Tyr Gln Val Ile Arg
              20                  25                  30        
 Met Pro Phe Cys His Leu Ser Thr Tyr Ser Leu Val Trp Val Met Ala
          35                  40                  45            
 Ala Val Val Leu Cys Thr Ala Gln Val Gln Val Val Thr Gln Asp Glu
      50                  55                  60                
 Arg Glu Gln Leu Tyr Thr Pro Ala Ser Leu Lys Cys Ser Leu Gln Asn
  65                  70                  75                  80
 Ala Gln Glu Ala Leu Ile Val Thr Trp Gln Lys Lys Lys Ala Val Ser
                  85                  90                  95    
 Pro Glu Asn Met Val Thr Phe Ser Glu Asn His Gly Val Val Ile Gln
             100                 105                 110        
 Pro Ala Tyr Lys Asp Lys Ile Asn Ile Thr Gln Leu Gly Leu Gln Asn
         115                 120                 125            
 Ser Thr Ile Thr Phe Trp Asn Ile Thr Leu Glu Asp Glu Gly Cys Tyr
     130                 135                 140                
 Met Cys Leu Phe Asn Thr Phe Gly Phe Gly Lys Ile Ser Gly Thr Ala
 145                 150                 155                 160
 Cys Leu Thr Val Tyr Val Gln Pro Ile Val Ser Leu His Tyr Lys Phe
                 165                 170                 175    
 Ser Glu Asp His Leu Asn Ile Thr Cys Ser Ala Thr Ala Arg Pro Ala
             180                 185                 190        
 Pro Met Val Phe Trp Lys Val Pro Arg Ser Gly Ile Glu Asn Ser Thr
         195                 200                 205            
 Val Thr Leu Ser His Pro Asn Gly Thr Thr Ser Val Thr Ser Ile Leu
     210                 215                 220                
 His Ile Lys Asp Pro Lys Asn Gln Val Gly Lys Glu Val Ile Cys Gln
 225                 230                 235                 240
 Val Leu His Leu Gly Thr Val Thr Asp Phe Lys Gln Thr Val Asn Lys
                 245                 250                 255    
 Gly Tyr Trp Phe Ser Val Pro Leu Leu Leu Ser Ile Val Ser Leu Val
             260                 265                 270        
 Ile Leu Leu Val Leu Ile Ser Ile Leu Leu Tyr Trp Lys Arg His Arg
         275                 280                 285            
 Asn Gln Asp Arg Glu Pro
     290                



      <210> 297
      <211> 314
      <212> PRT
      <213> Homo sapiens


      <400> 297
 Met Ala Leu Leu Val Asp Arg Val Arg Gly His Trp Arg Ile Ala Ala
   1               5                  10                  15    
 Gly Leu Leu Phe Asn Leu Leu Val Ser Ile Cys Ile Val Phe Leu Asn
              20                  25                  30        
 Lys Trp Ile Tyr Val Tyr His Gly Phe Pro Asn Met Ser Leu Thr Leu
          35                  40                  45            
 Val His Phe Val Val Thr Trp Leu Gly Leu Tyr Ile Cys Gln Lys Leu
      50                  55                  60                
 Asp Ile Phe Ala Pro Lys Ser Leu Pro Pro Ser Arg Leu Leu Leu Leu
  65                  70                  75                  80
 Ala Leu Ser Phe Cys Gly Phe Val Val Phe Thr Asn Leu Ser Leu Gln
                  85                  90                  95    
 Asn Asn Thr Ile Gly Thr Tyr Gln Leu Ala Lys Ala Met Thr Thr Pro
             100                 105                 110        
 Val Ile Ile Ala Ile Gln Thr Phe Cys Tyr Gln Lys Thr Phe Ser Thr
         115                 120                 125            
 Arg Ile Gln Leu Thr Leu Ile Pro Ile Thr Leu Gly Val Ile Leu Asn
     130                 135                 140                
 Ser Tyr Tyr Asp Val Lys Phe Asn Phe Leu Gly Met Val Phe Ala Ala
 145                 150                 155                 160
 Leu Gly Val Leu Val Thr Ser Leu Tyr Gln Val Trp Val Gly Ala Lys
                 165                 170                 175    
 Gln His Glu Leu Gln Val Asn Ser Met Gln Leu Leu Tyr Tyr Gln Ala
             180                 185                 190        
 Pro Met Ser Ser Ala Met Leu Leu Val Ala Val Pro Phe Phe Glu Pro
         195                 200                 205            
 Val Phe Gly Glu Gly Gly Ile Phe Gly Pro Trp Ser Val Ser Ala Leu
     210                 215                 220                
 Leu Met Val Leu Leu Ser Gly Val Ile Ala Phe Met Val Asn Leu Ser
 225                 230                 235                 240
 Ile Tyr Trp Ile Ile Gly Asn Thr Ser Pro Val Thr Tyr Asn Met Phe
                 245                 250                 255    
 Gly His Phe Lys Phe Cys Ile Thr Leu Phe Gly Gly Tyr Val Leu Phe
             260                 265                 270        
 Lys Asp Pro Leu Ser Ile Asn Gln Ala Leu Gly Ile Leu Cys Thr Leu
         275                 280                 285            
 Phe Gly Ile Leu Ala Tyr Thr His Phe Lys Leu Ser Glu Gln Glu Gly
     290                 295                 300                
 Ser Arg Ser Lys Leu Ala Gln Arg Pro
 305                 310            



      <210> 298
      <211> 114
      <212> PRT
      <213> Homo sapiens


      <400> 298
 Met Glu His Phe Ile Leu Asn Ser Phe Asn Asn Ile Ile Ile Phe Gln
   1               5                  10                  15    
 Leu Ser Leu Gly Leu Thr Leu Ser Pro Arg Leu Glu Cys Ser Gly Met
              20                  25                  30        
 Ile Thr Ala His Cys Gly Leu Gln Leu Leu Gly Ser Ser Asp Ser Pro
          35                  40                  45            
 Ala Pro Ala Ser Arg Val Ala Gly Thr Thr Gly Leu Arg His His Ala
      50                  55                  60                
 Arg Leu Ile Gly His Phe Arg Trp Lys Gln Met Thr Gly Ser Leu Thr
  65                  70                  75                  80
 Pro Thr Phe Leu Ser Ser Leu Pro Val Met Leu Leu Leu Lys Ala Gly
                  85                  90                  95    
 Arg Glu Thr Pro Trp Leu Lys Ser Arg Ala Arg Ala Ser Lys Trp Ser
             100                 105                 110        
 Leu
    



      <210> 299
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 299
 Met Leu Thr Glu Asn Gly Gln Val Leu Ser Cys Gly Ser Asn Ser Phe
   1               5                  10                  15    
 Gly Gln Leu Gly Val Pro His Gly Pro Arg Arg Cys Val Val Pro Gln
              20                  25                  30        
 Ala Ile Glu Leu His Lys Glu Lys Val Val Cys Ile Ala Ala Gly Leu
          35                  40                  45            
 Arg His Ala Val Ala Ala Thr Gly Leu Glu Asn Ser Lys Ala Met Cys
      50                  55                  60                
 Val Leu Ala Gly Ser Asp His Ser Ala Ser Leu Thr Asp Ala Gly Glu
  65                  70                  75                  80
 Val Tyr Val Trp Gly Ser Asn Lys His Gly Gln Leu Ala Asn Glu Ala
                  85                  90                  95    
 Ala Phe Leu Pro Val Pro Gln Lys Ile Glu Ala His Cys Phe Gln Asn
             100                 105                 110        
 Glu Lys Val Thr Ala Ile Trp Ser Gly Trp Thr His Leu Val Ala Gln
         115                 120                 125            
 Thr Gly Leu Leu Trp Leu Arg Ala
     130                 135    



      <210> 300
      <211> 175
      <212> PRT
      <213> Homo sapiens


      <400> 300
 Met Leu Thr Glu Asn Gly Gln Val Leu Ser Cys Gly Ser Asn Ser Phe
   1               5                  10                  15    
 Gly Gln Leu Gly Val Pro His Gly Pro Arg Arg Cys Val Val Pro Gln
              20                  25                  30        
 Ala Ile Glu Leu His Lys Glu Lys Val Val Cys Ile Ala Ala Gly Leu
          35                  40                  45            
 Arg His Ala Val Ala Ala Thr Ala Ser Gly Ile Val Phe Gln Trp Gly
      50                  55                  60                
 Thr Gly Leu Ala Ser Cys Gly Arg Arg Leu Cys Pro Gly Gln Thr Leu
  65                  70                  75                  80
 Pro Leu Phe Phe Thr Ala Lys Glu Pro Ser Arg Val Thr Gly Leu Glu
                  85                  90                  95    
 Asn Ser Lys Ala Met Cys Val Leu Ala Gly Ser Asp His Ser Ala Ser
             100                 105                 110        
 Leu Thr Asp Ala Gly Glu Val Tyr Val Trp Gly Ser Asn Lys His Gly
         115                 120                 125            
 Gln Leu Ala Asn Glu Ala Ala Phe Leu Pro Val Pro Gln Lys Ile Glu
     130                 135                 140                
 Ala His Cys Phe Gln Asn Glu Lys Val Thr Ala Ile Trp Ser Gly Trp
 145                 150                 155                 160
 Thr His Leu Val Ala Gln Thr Gly Leu Leu Trp Leu Arg Ala
                 165                 170                



      <210> 301
      <211> 36
      <212> PRT
      <213> Homo sapiens


      <400> 301
 Met Glu Glu Met Gly Asn Arg Ile Glu Asp Leu Gln Lys Asn Val Asn
   1               5                  10                  15    
 Asp Leu Met Val Gln Ala Gly Ile Glu Asn Ser Ile Lys Glu Gln Met
              20                  25                  30        
 Leu Lys Thr
          35



      <210> 302
      <211> 62
      <212> PRT
      <213> Homo sapiens


      <400> 302
 Met Asp Pro Asn Cys Ser Cys Thr Thr Gly Gly Ser Cys Ala Cys Ala
   1               5                  10                  15    
 Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Cys
              20                  25                  30        
 Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly Cys
          35                  40                  45            
 Val Cys Lys Gly Ser Ser Glu Lys Cys Arg Cys Cys Ala
      50                  55                  60    



      <210> 303
      <211> 337
      <212> PRT
      <213> Homo sapiens


      <400> 303
 Met Ala Arg Arg Arg Ser Gln Arg Val Cys Ala Ser Gly Pro Ser Met
   1               5                  10                  15    
 Leu Asn Ser Ala Arg Gly Ala Pro Glu Leu Leu Arg Gly Thr Ala Thr
              20                  25                  30        
 Asn Ala Glu Val Ser Ala Ala Ala Ala Gly Ala Thr Gly Ser Glu Glu
          35                  40                  45            
 Leu Pro Pro Gly Asp Arg Gly Cys Arg Asn Gly Gly Gly Arg Gly Pro
      50                  55                  60                
 Ala Ala Thr Thr Ser Ser Thr Gly Val Ala Val Gly Ala Glu His Gly
  65                  70                  75                  80
 Glu Asp Ser Leu Ser Arg Lys Pro Asp Pro Glu Pro Gly Arg Met Asp
                  85                  90                  95    
 His His Gln Pro Gly Thr Gly Arg Tyr Gln Val Leu Leu Asn Glu Glu
             100                 105                 110        
 Asp Asn Ser Glu Ser Ser Ala Ile Glu Gln Pro Pro Thr Ser Asn Pro
         115                 120                 125            
 Ala Pro Gln Ile Val Gln Ala Ala Ser Ser Ala Pro Ala Leu Glu Thr
     130                 135                 140                
 Asp Ser Ser Pro Pro Pro Tyr Ser Ser Ile Thr Val Glu Val Pro Thr
 145                 150                 155                 160
 Thr Ser Asp Thr Glu Val Tyr Gly Glu Phe Tyr Pro Val Pro Pro Pro
                 165                 170                 175    
 Tyr Ser Val Ala Thr Ser Leu Pro Thr Tyr Asp Glu Ala Glu Lys Ala
             180                 185                 190        
 Lys Ala Ala Ala Met Ala Ala Ala Ala Ala Glu Thr Ser Gln Arg Ile
         195                 200                 205            
 Gln Glu Glu Glu Cys Pro Pro Arg Asp Asp Phe Ser Asp Ala Asp Gln
     210                 215                 220                
 Leu Arg Val Gly Asn Asp Gly Ile Phe Met Leu Ala Phe Phe Met Ala
 225                 230                 235                 240
 Phe Ile Phe Asn Trp Leu Gly Phe Cys Leu Ser Phe Cys Ile Thr Asn
                 245                 250                 255    
 Thr Ile Ala Gly Arg Tyr Gly Ala Ile Cys Gly Phe Gly Leu Ser Leu
             260                 265                 270        
 Ile Lys Trp Ile Leu Ile Val Arg Phe Ser Asp Tyr Phe Thr Gly Tyr
         275                 280                 285            
 Phe Asn Gly Gln Tyr Trp Leu Trp Trp Ile Phe Leu Val Leu Gly Leu
     290                 295                 300                
 Leu Leu Phe Phe Arg Gly Phe Val Asn Tyr Leu Lys Val Arg Asn Met
 305                 310                 315                 320
 Ser Glu Ser Met Ala Ala Ala His Arg Thr Arg Tyr Phe Phe Leu Leu
                 325                 330                 335    





      <210> 304
      <211> 270
      <212> PRT
      <213> Homo sapiens


      <400> 304
 Met Cys Pro Gly Arg Cys Ala Ser Thr Leu Gly Arg Arg Val Arg Cys
   1               5                  10                  15    
 Lys Val Phe Pro Ile Lys His Tyr Gln Asp Lys Ile Arg Pro Tyr Ile
              20                  25                  30        
 Gln Leu Pro Ser His Ser Asn Ile Thr Gly Ile Val Glu Val Ile Leu
          35                  40                  45            
 Gly Glu Thr Lys Ala Tyr Val Phe Phe Glu Lys Asp Phe Gly Asp Met
      50                  55                  60                
 His Ser Tyr Val Arg Ser Arg Lys Arg Leu Arg Glu Glu Glu Ala Ala
  65                  70                  75                  80
 Arg Leu Phe Lys Gln Ile Val Ser Ala Val Ala His Cys His Gln Ser
                  85                  90                  95    
 Ala Ile Val Leu Gly Asp Leu Lys Leu Arg Lys Phe Val Phe Ser Thr
             100                 105                 110        
 Glu Glu Arg Thr Gln Leu Arg Leu Glu Ser Leu Glu Asp Thr His Ile
         115                 120                 125            
 Met Lys Gly Glu Asp Asp Ala Leu Ser Asp Lys His Gly Cys Pro Ala
     130                 135                 140                
 Tyr Val Ser Pro Glu Ile Leu Asn Thr Thr Gly Thr Tyr Ser Gly Lys
 145                 150                 155                 160
 Ala Ala Asp Val Trp Ser Leu Gly Val Met Leu Tyr Thr Leu Leu Val
                 165                 170                 175    
 Gly Arg Tyr Pro Phe His Asp Ser Asp Pro Ser Ala Leu Phe Ser Lys
             180                 185                 190        
 Ile Arg Arg Gly Gln Phe Cys Ile Pro Glu His Ile Ser Pro Lys Ala
         195                 200                 205            
 Arg Cys Leu Ile Arg Ser Leu Leu Arg Arg Glu Pro Ser Glu Arg Leu
     210                 215                 220                
 Thr Ala Pro Glu Ile Leu Leu His Pro Trp Phe Glu Ser Val Leu Glu
 225                 230                 235                 240
 Pro Gly Tyr Ile Asp Ser Glu Ile Gly Thr Ser Asp Gln Ile Val Pro
                 245                 250                 255    
 Glu Tyr Gln Glu Asp Ser Asp Ile Ser Ser Phe Phe Cys
             260                 265                



      <210> 305
      <211> 123
      <212> PRT
      <213> Homo sapiens


      <400> 305
 Met Thr Ser Pro Glu Ile Ala Ser Leu Ser Trp Gly Gln Met Lys Val
   1               5                  10                  15    
 Lys Gly Ser Asn Thr Thr Tyr Lys Asp Cys Lys Val Trp Pro Gly Gly
              20                  25                  30        
 Ser Arg Thr Trp Asp Trp Arg Glu Thr Gly Thr Glu His Ser Pro Gly
          35                  40                  45            
 Val Gln Pro Ala Asp Val Lys Glu Val Val Glu Lys Gly Val Gln Thr
      50                  55                  60                
 Leu Val Ile Gly Arg Gly Met Ser Glu Ala Leu Lys Val Pro Ser Ser
  65                  70                  75                  80
 Thr Val Glu Tyr Leu Lys Lys His Gly Ile Asp Val Arg Val Leu Gln
                  85                  90                  95    
 Thr Glu Gln Ala Val Lys Glu Tyr Asn Ala Leu Val Ala Gln Gly Val
             100                 105                 110        
 Arg Val Gly Gly Val Phe His Ser Thr Cys
         115                 120        



      <210> 306
      <211> 1382
      <212> PRT
      <213> Homo sapiens


      <400> 306
 Met Gly Ser Leu Thr Ser Ser Pro Ser Ser Cys Ser Leu Ser Ser Gln
   1               5                  10                  15    
 Val Gly Leu Thr Ser Val Thr Ser Ile Gln Glu Arg Ile Met Ser Thr
              20                  25                  30        
 Pro Gly Gly Glu Glu Ala Ile Glu Arg Leu Lys Glu Ser Glu Lys Ile
          35                  40                  45            
 Ile Ala Glu Leu Asn Glu Thr Trp Glu Glu Lys Leu Arg Lys Thr Glu
      50                  55                  60                
 Ala Ile Arg Met Glu Arg Glu Ala Leu Leu Ala Glu Met Gly Val Ala
  65                  70                  75                  80
 Ile Arg Glu Asp Gly Gly Thr Leu Gly Val Phe Ser Pro Lys Lys Thr
                  85                  90                  95    
 Pro His Leu Val Asn Leu Asn Glu Asp Pro Leu Met Ser Glu Cys Leu
             100                 105                 110        
 Leu Tyr Tyr Ile Lys Asp Gly Ile Thr Arg Val Gly Gln Ala Asp Ala
         115                 120                 125            
 Glu Arg Arg Gln Asp Ile Val Leu Ser Gly Ala His Ile Lys Glu Glu
     130                 135                 140                
 His Cys Ile Phe Arg Ser Glu Arg Ser Asn Ser Gly Glu Val Ile Val
 145                 150                 155                 160
 Thr Leu Glu Pro Cys Glu Arg Ser Glu Thr Tyr Val Asn Gly Lys Arg
                 165                 170                 175    
 Val Ser Gln Pro Val Gln Leu Arg Ser Gly Asn Arg Ile Ile Met Gly
             180                 185                 190        
 Lys Asn His Val Phe Arg Phe Asn His Pro Glu Gln Ala Arg Ala Glu
         195                 200                 205            
 Arg Glu Lys Thr Pro Ser Ala Glu Thr Pro Ser Glu Pro Val Asp Trp
     210                 215                 220                
 Thr Phe Ala Gln Arg Glu Leu Leu Glu Lys Gln Gly Ile Asp Met Lys
 225                 230                 235                 240
 Gln Glu Met Glu Lys Arg Leu Gln Glu Met Glu Ile Leu Tyr Lys Lys
                 245                 250                 255    
 Glu Lys Glu Glu Ala Asp Leu Leu Leu Glu Gln Gln Arg Leu Asp Tyr
             260                 265                 270        
 Glu Ser Lys Leu Gln Ala Leu Gln Lys Gln Val Glu Thr Arg Ser Leu
         275                 280                 285            
 Ala Ala Glu Thr Thr Glu Glu Glu Glu Glu Glu Glu Glu Val Pro Trp
     290                 295                 300                
 Thr Gln His Glu Phe Glu Leu Ala Gln Trp Ala Phe Arg Lys Trp Lys
 305                 310                 315                 320
 Ser His Gln Phe Thr Ser Leu Arg Asp Leu Leu Trp Gly Asn Ala Val
                 325                 330                 335    
 Tyr Leu Lys Glu Ala Asn Ala Ile Ser Val Glu Leu Lys Lys Lys Val
             340                 345                 350        
 Gln Phe Gln Phe Val Leu Leu Thr Asp Thr Leu Tyr Ser Pro Leu Pro
         355                 360                 365            
 Pro Glu Leu Leu Pro Thr Glu Met Glu Lys Thr His Glu Asp Arg Pro
     370                 375                 380                
 Phe Pro Arg Thr Val Val Ala Val Glu Val Gln Asp Leu Lys Asn Gly
 385                 390                 395                 400
 Ala Thr His Tyr Trp Ser Leu Glu Lys Leu Lys Gln Arg Leu Asp Leu
                 405                 410                 415    
 Met Arg Glu Met Tyr Asp Arg Ala Gly Glu Met Ala Ser Ser Ala Gln
             420                 425                 430        
 Asp Glu Ser Glu Thr Thr Val Thr Gly Ser Asp Pro Phe Tyr Asp Arg
         435                 440                 445            
 Phe His Trp Phe Lys Leu Val Gly Ser Ser Pro Ile Phe His Gly Cys
     450                 455                 460                
 Val Asn Glu Arg Leu Ala Asp Arg Thr Pro Ser Pro Thr Phe Ser Thr
 465                 470                 475                 480
 Ala Asp Ser Asp Ile Thr Glu Leu Ala Asp Glu Gln Gln Asp Glu Met
                 485                 490                 495    
 Glu Asp Phe Asp Asp Glu Ala Phe Val Asp Asp Ala Gly Ser Asp Ala
             500                 505                 510        
 Gly Thr Glu Glu Gly Ser Asp Leu Phe Ser Asp Gly His Asp Pro Phe
         515                 520                 525            
 Tyr Asp Arg Ser Pro Trp Phe Ile Leu Val Gly Arg Ala Phe Val Tyr
     530                 535                 540                
 Leu Ser Asn Leu Leu Tyr Pro Val Pro Leu Ile His Arg Val Ala Ile
 545                 550                 555                 560
 Val Ser Glu Lys Gly Glu Val Arg Gly Phe Leu Arg Val Ala Val Gln
                 565                 570                 575    
 Ala Ile Ala Ala Asp Glu Glu Ala Pro Asp Tyr Gly Ser Gly Ile Arg
             580                 585                 590        
 Gln Ser Gly Thr Ala Lys Ile Ser Phe Asp Asn Glu Tyr Phe Asn Gln
         595                 600                 605            
 Ser Asp Phe Ser Ser Val Ala Met Thr Arg Ser Gly Leu Ser Leu Glu
     610                 615                 620                
 Glu Leu Arg Ile Val Glu Gly Gln Gly Gln Ser Ser Glu Val Ile Thr
 625                 630                 635                 640
 Pro Pro Glu Glu Ile Ser Arg Ile Asn Asp Leu Asp Leu Lys Ser Ser
                 645                 650                 655    
 Thr Leu Leu Asp Gly Lys Met Val Met Glu Gly Phe Ser Glu Glu Ile
             660                 665                 670        
 Gly Asn His Leu Lys Leu Gly Ser Ala Phe Thr Phe Arg Val Thr Val
         675                 680                 685            
 Leu Gln Ala Ser Gly Ile Leu Pro Glu Tyr Ala Asp Ile Phe Cys Gln
     690                 695                 700                
 Phe Asn Phe Leu His Arg His Asp Glu Ala Phe Ser Thr Glu Pro Leu
 705                 710                 715                 720
 Lys Asn Asn Gly Arg Gly Ser Pro Leu Ala Phe Tyr His Val Gln Asn
                 725                 730                 735    
 Ile Ala Val Glu Ile Thr Glu Ser Phe Val Asp Tyr Ile Lys Thr Lys
             740                 745                 750        
 Pro Ile Val Phe Glu Val Phe Gly His Tyr Gln Gln His Pro Leu His
         755                 760                 765            
 Leu Gln Gly Gln Glu Leu Asn Ser Pro Pro Gln Pro Cys Arg Arg Phe
     770                 775                 780                
 Phe Pro Pro Pro Met Pro Leu Ser Lys Pro Val Pro Ala Thr Lys Leu
 785                 790                 795                 800
 Asn Thr Met Ser Lys Thr Ser Leu Gly Gln Ser Met Ser Lys Tyr Asp
                 805                 810                 815    
 Leu Leu Val Trp Phe Glu Ile Ser Glu Leu Glu Pro Thr Gly Glu Tyr
             820                 825                 830        
 Ile Pro Ala Val Val Asp His Thr Ala Gly Leu Pro Cys Gln Gly Thr
         835                 840                 845            
 Phe Leu Leu His Gln Gly Ile Gln Arg Arg Ile Thr Val Thr Ile Ile
     850                 855                 860                
 His Glu Lys Gly Ser Glu Leu His Trp Lys Asp Val Arg Glu Leu Val
 865                 870                 875                 880
 Val Gly Arg Ile Arg Asn Lys Pro Glu Val Asp Glu Ala Ala Val Asp
                 885                 890                 895    
 Ala Ile Leu Ser Leu Asn Ile Ile Ser Ala Lys Tyr Leu Lys Ser Ser
             900                 905                 910        
 His Asn Ser Ser Arg Thr Phe Tyr Arg Phe Glu Ala Val Trp Asp Ser
         915                 920                 925            
 Ser Leu His Asn Ser Leu Leu Leu Asn Arg Val Thr Pro Tyr Gly Glu
     930                 935                 940                
 Lys Ile Tyr Met Thr Leu Ser Ala Tyr Leu Glu Leu Asp His Cys Ile
 945                 950                 955                 960
 Gln Pro Ala Val Ile Thr Lys Asp Val Cys Met Val Phe Tyr Ser Arg
                 965                 970                 975    
 Asp Ala Lys Ile Ser Pro Pro Arg Ser Leu Arg Ser Leu Phe Gly Ser
             980                 985                 990        
 Gly Tyr Ser Lys Ser Pro Asp Ser Asn Arg Val Thr Gly Ile Tyr Glu
         995                1000                1005            
 Leu Ser Leu Cys Lys Met Ser Asp Thr Gly Ser Pro Gly Met Gln Arg
    1010                1015                1020                
 Arg Arg Arg Lys Ile Leu Asp Thr Ser Val Ala Tyr Val Arg Gly Glu
1025                1030                1035                1040
 Glu Asn Leu Ala Gly Trp Arg Pro Arg Gly Asp Ser Leu Ile Leu Glu
                1045                1050                1055    
 His Gln Trp Glu Leu Glu Lys Leu Glu Leu Leu His Glu Val Glu Lys
            1060                1065                1070        
 Thr Arg His Phe Leu Leu Leu Arg Glu Arg Leu Gly Asp Ser Ile Pro
        1075                1080                1085            
 Lys Ser Leu Ser Asp Ser Leu Ser Pro Ser Leu Ser Ser Gly Thr Leu
    1090                1095                1100                
 Ser Thr Ser Thr Ser Ile Ser Ser Gln Ile Ser Thr Thr Thr Phe Glu
1105                1110                1115                1120
 Ser Ala Ile Thr Pro Ser Glu Ser Ser Gly Tyr Asp Ser Gly Asp Ile
                1125                1130                1135    
 Glu Ser Leu Val Asp Arg Glu Lys Glu Leu Ala Thr Lys Cys Leu Gln
            1140                1145                1150        
 Leu Leu Thr His Thr Phe Asn Arg Glu Phe Ser Gln Val His Gly Ser
        1155                1160                1165            
 Val Ser Asp Cys Lys Leu Ser Asp Ile Ser Pro Ile Gly Arg Asp Pro
    1170                1175                1180                
 Ser Glu Ser Ser Phe Ser Ser Ala Thr Leu Thr Pro Ser Ser Thr Cys
1185                1190                1195                1200
 Pro Ser Leu Val Asp Ser Arg Ser Asn Ser Leu Asp Gln Lys Thr Pro
                1205                1210                1215    
 Glu Ala Asn Ser Arg Ala Ser Ser Pro Cys Pro Glu Phe Glu Gln Phe
            1220                1225                1230        
 Gln Ile Val Pro Ala Val Glu Thr Pro Tyr Leu Ala Arg Ala Gly Lys
        1235                1240                1245            
 Asn Glu Phe Leu Asn Leu Val Pro Asp Ile Glu Glu Ile Arg Pro Ser
    1250                1255                1260                
 Ser Val Val Ser Lys Lys Gly Tyr Leu His Phe Lys Glu Pro Leu Tyr
1265                1270                1275                1280
 Ser Asn Trp Ala Lys His Phe Val Val Val Arg Arg Pro Tyr Val Phe
                1285                1290                1295    
 Ile Tyr Asn Ser Asp Lys Asp Pro Val Glu Arg Gly Ile Ile Asn Leu
            1300                1305                1310        
 Ser Thr Ala Gln Val Glu Tyr Ser Glu Asp Gln Gln Ala Met Val Lys
        1315                1320                1325            
 Thr Pro Asn Thr Phe Ala Val Cys Thr Lys His Arg Gly Val Leu Leu
    1330                1335                1340                
 Gln Ala Leu Asn Asp Lys Asp Met Asn Asp Trp Leu Tyr Ala Phe Asn
1345                1350                1355                1360
 Pro Leu Leu Ala Gly Thr Ile Arg Ser Lys Leu Ser Arg Arg Cys Pro
                1365                1370                1375    
 Ser Gln Ser Lys Tyr
            1380    



      <210> 307
      <211> 221
      <212> PRT
      <213> Homo sapiens


      <400> 307
 Met Glu Arg Tyr Ala Gly Ala Leu Glu Glu Val Ala Asp Gly Ala Arg
   1               5                  10                  15    
 Gln Gln Glu Arg His Tyr Gln Leu Leu Ser Ala Leu Gln Ser Leu Val
              20                  25                  30        
 Lys Glu Leu Pro Ser Ser Phe Gln Gln Arg Leu Ser Tyr Thr Thr Leu
          35                  40                  45            
 Ser Asp Leu Ala Leu Ala Leu Leu Asp Gly Thr Val Phe Glu Ile Val
      50                  55                  60                
 Gln Gly Leu Leu Glu Ile Gln His Leu Thr Glu Lys Ser Leu Tyr Asn
  65                  70                  75                  80
 Gln Arg Leu Arg Leu Gln Asn Glu His Arg Val Leu Arg Gln Ala Leu
                  85                  90                  95    
 Arg Gln Lys His Gln Glu Ala Gln Gln Ala Cys Arg Pro His Asn Leu
             100                 105                 110        
 Pro Val Leu Gln Ala Ala Gln Gln Arg Glu Leu Glu Ala Val Glu His
         115                 120                 125            
 Arg Ile Arg Glu Glu Gln Arg Ala Met Asp Gln Lys Ile Val Leu Glu
     130                 135                 140                
 Leu Asp Arg Lys Val Ala Asp Gln Gln Ser Thr Leu Glu Lys Ala Gly
 145                 150                 155                 160
 Val Ala Gly Phe Tyr Val Thr Thr Asn Pro Gln Glu Leu Met Leu Gln
                 165                 170                 175    
 Met Asn Leu Leu Glu Leu Ile Arg Lys Leu Gln Gln Arg Gly Cys Trp
             180                 185                 190        
 Ala Gly Lys Ala Ala Leu Gly Leu Gly Gly Pro Trp Gln Leu Pro Ala
         195                 200                 205            
 Ala Gln Cys Asp Gln Lys Gly Ser Pro Val Pro Pro
     210                 215                 220



      <210> 308
      <211> 330
      <212> PRT
      <213> Homo sapiens


      <400> 308
 Met Ala Leu Gly Pro Arg Cys Gly Ala Ile Arg Ala Cys Arg Arg Val
   1               5                  10                  15    
 Leu Glu Arg Ala Phe Ser Leu Arg Lys Ala His Ser Ile Lys Asp Met
              20                  25                  30        
 Glu Asn Thr Leu Gln Leu Val Arg Asn Ile Ile Pro Pro Leu Ser Ser
          35                  40                  45            
 Thr Lys His Lys Gly Gln Asp Gly Arg Ile Gly Val Val Gly Gly Cys
      50                  55                  60                
 Gln Glu Tyr Thr Gly Ala Pro Tyr Phe Ala Ala Ile Ser Ala Leu Lys
  65                  70                  75                  80
 Val Gly Ala Asp Leu Ser His Val Phe Cys Ala Ser Ala Ala Ala Pro
                  85                  90                  95    
 Val Ile Lys Ala Tyr Ser Pro Glu Leu Ile Val His Pro Val Leu Asp
             100                 105                 110        
 Ser Pro Asn Ala Val His Glu Val Glu Lys Trp Leu Pro Arg Leu His
         115                 120                 125            
 Ala Leu Val Val Gly Pro Gly Leu Gly Arg Asp Asp Ala Leu Leu Arg
     130                 135                 140                
 Asn Val Gln Gly Ile Leu Glu Val Ser Lys Ala Arg Asp Ile Pro Val
 145                 150                 155                 160
 Val Ile Asp Ala Asp Gly Leu Trp Leu Val Ala Gln Gln Pro Ala Leu
                 165                 170                 175    
 Ile His Gly Tyr Arg Lys Ala Val Leu Thr Pro Asn His Val Glu Phe
             180                 185                 190        
 Ser Arg Leu Tyr Asp Ala Val Leu Arg Gly Pro Met Asp Ser Asp Asp
         195                 200                 205            
 Ser His Gly Ser Val Leu Arg Leu Ser Gln Ala Leu Gly Asn Val Thr
     210                 215                 220                
 Val Val Gln Lys Gly Glu Arg Asp Ile Leu Ser Asn Gly Gln Gln Val
 225                 230                 235                 240
 Leu Val Cys Ser Gln Glu Gly Ser Ser Arg Arg Cys Gly Gly Gln Gly
                 245                 250                 255    
 Asp Leu Leu Ser Gly Ser Leu Gly Val Leu Val His Trp Ala Leu Leu
             260                 265                 270        
 Ala Gly Pro Gln Lys Thr Asn Gly Ser Ser Pro Leu Leu Val Ala Ala
         275                 280                 285            
 Phe Gly Ala Cys Ser Leu Thr Arg Gln Cys Asn His Gln Ala Phe Gln
     290                 295                 300                
 Lys His Gly Arg Ser Thr Thr Thr Ser Asp Met Ile Ala Glu Val Gly
 305                 310                 315                 320
 Ala Ala Phe Ser Lys Leu Phe Glu Thr
                 325                



      <210> 309
      <211> 387
      <212> PRT
      <213> Homo sapiens


      <400> 309
 Met Glu Arg Pro Ala Ser Pro Gln Met Ala Ser Ser Ser Pro Asp Ser
   1               5                  10                  15    
 Pro Cys Ser Cys Asp Cys Phe Val Ser Val Pro Pro Ala Ser Ala Ile
              20                  25                  30        
 Pro Ala Val Ile Phe Ala Lys Asn Ser Asp Arg Pro Arg Asp Glu Val
          35                  40                  45            
 Gln Glu Gly Val Phe Val Pro Ala Gly Thr His Thr Pro Gly Ser Arg
      50                  55                  60                
 Leu Gln Cys Thr Tyr Ile Glu Val Glu Gln Val Ser Lys Thr His Ala
  65                  70                  75                  80
 Val Ile Leu Ser Arg Pro Ser Trp Leu Trp Gly Ala Glu Met Gly Ala
                  85                  90                  95    
 Asn Glu His Gly Val Cys Ile Gly Asn Glu Ala Val Trp Thr Lys Glu
             100                 105                 110        
 Pro Val Gly Glu Gly Glu Ala Leu Leu Gly Met Asp Leu Leu Arg Leu
         115                 120                 125            
 Ala Leu Glu Arg Ser Ser Ser Ala Gln Glu Ala Leu His Val Ile Thr
     130                 135                 140                
 Gly Leu Leu Glu His Tyr Gly Gln Gly Gly Asn Cys Leu Glu Asp Ala
 145                 150                 155                 160
 Ala Pro Phe Ser Tyr His Ser Thr Phe Leu Leu Ala Asp Arg Thr Glu
                 165                 170                 175    
 Ala Trp Val Leu Glu Thr Ala Gly Arg Leu Trp Ala Ala Gln Arg Ile
             180                 185                 190        
 Gln Glu Gly Ala Arg Asn Ile Ser Asn Gln Leu Ser Ile Gly Thr Asp
         195                 200                 205            
 Ile Ser Ala Gln His Pro Glu Leu Arg Thr His Ala Gln Ala Lys Gly
     210                 215                 220                
 Trp Trp Asp Gly Gln Gly Ala Phe Asp Phe Ala Gln Ile Phe Ser Leu
 225                 230                 235                 240
 Thr Gln Gln Pro Val Arg Met Glu Ala Ala Lys Ala Arg Phe Gln Ala
                 245                 250                 255    
 Gly Arg Glu Leu Leu Arg Gln Arg Gln Gly Gly Ile Thr Ala Glu Val
             260                 265                 270        
 Met Met Gly Ile Leu Arg Asp Lys Glu Ser Gly Ile Cys Met Asp Ser
         275                 280                 285            
 Gly Gly Phe Arg Thr Thr Ala Ser Met Val Ser Val Leu Pro Gln Asp
     290                 295                 300                
 Pro Thr Gln Pro Cys Val His Phe Leu Thr Ala Thr Pro Asp Pro Ser
 305                 310                 315                 320
 Arg Ser Val Phe Lys Pro Phe Ile Phe Gly Val Gly Val Ala Gln Ala
                 325                 330                 335    
 Pro Gln Val Leu Ser Pro Thr Phe Gly Ala Gln Asp Pro Val Arg Thr
             340                 345                 350        
 Leu Pro Arg Phe Gln Thr Gln Val Asp Arg Arg His Thr Leu Tyr Arg
         355                 360                 365            
 Gly His Gln Ala Ala Leu Gly Leu Met Glu Arg Asp Gln Val Ser Pro
     370                 375                 380                
 Arg Glu
 385    



      <210> 310
      <211> 484
      <212> PRT
      <213> Homo sapiens


      <400> 310
 Met Glu Glu Gly Gly Gly Gly Val Arg Ser Leu Val Pro Gly Gly Pro
   1               5                  10                  15    
 Val Leu Leu Val Leu Cys Gly Leu Leu Glu Ala Ser Gly Gly Gly Arg
              20                  25                  30        
 Ala Leu Pro Gln Leu Ser Asp Asp Ile Pro Phe Arg Val Asn Trp Pro
          35                  40                  45            
 Gly Thr Glu Phe Ser Leu Pro Thr Thr Gly Val Leu Tyr Lys Glu Asp
      50                  55                  60                
 Asn Tyr Val Ile Met Thr Thr Ala His Lys Glu Lys Tyr Lys Cys Ile
  65                  70                  75                  80
 Leu Pro Leu Val Thr Ser Gly Asp Glu Glu Glu Glu Lys Asp Tyr Lys
                  85                  90                  95    
 Gly Pro Asn Pro Arg Glu Leu Leu Glu Pro Leu Phe Lys Gln Ser Ser
             100                 105                 110        
 Cys Ser Tyr Arg Ile Glu Ser Tyr Trp Thr Tyr Glu Val Cys His Gly
         115                 120                 125            
 Lys His Ile Arg Gln Tyr His Glu Glu Lys Glu Thr Gly Gln Lys Ile
     130                 135                 140                
 Asn Ile His Glu Tyr Tyr Leu Gly Asn Met Leu Ala Lys Asn Leu Leu
 145                 150                 155                 160
 Phe Glu Lys Glu Arg Glu Ala Glu Glu Lys Glu Lys Ser Asn Glu Ile
                 165                 170                 175    
 Pro Thr Lys Asn Ile Glu Gly Gln Met Thr Pro Tyr Tyr Pro Val Gly
             180                 185                 190        
 Met Gly Asn Gly Thr Pro Cys Ser Leu Lys Gln Asn Arg Pro Arg Ser
         195                 200                 205            
 Ser Thr Val Met Tyr Ile Cys His Pro Glu Ser Lys His Glu Ile Leu
     210                 215                 220                
 Ser Val Ala Glu Val Thr Thr Cys Glu Tyr Glu Val Val Ile Leu Thr
 225                 230                 235                 240
 Pro Leu Leu Cys Ser His Pro Lys Tyr Arg Phe Arg Ala Ser Pro Val
                 245                 250                 255    
 Asn Asp Ile Phe Cys Gln Ser Leu Pro Gly Ser Pro Phe Lys Pro Leu
             260                 265                 270        
 Thr Leu Arg Gln Leu Glu Gln Gln Glu Glu Ile Leu Arg Val Pro Phe
         275                 280                 285            
 Arg Arg Asn Lys Glu Glu Asp Leu Gln Ser Thr Lys Glu Glu Arg Phe
     290                 295                 300                
 Pro Ala Ile His Lys Ser Ile Ala Ile Gly Ser Gln Pro Val Leu Thr
 305                 310                 315                 320
 Val Gly Thr Thr His Ile Ser Lys Leu Thr Asp Asp Gln Leu Ile Lys
                 325                 330                 335    
 Glu Phe Leu Ser Gly Ser Tyr Cys Phe Arg Gly Gly Val Gly Trp Trp
             340                 345                 350        
 Lys Tyr Glu Phe Cys Tyr Gly Lys His Val His Gln Tyr His Glu Asp
         355                 360                 365            
 Lys Asp Ser Gly Lys Thr Ser Val Val Val Gly Thr Trp Asn Gln Glu
     370                 375                 380                
 Glu His Ile Glu Trp Ala Lys Lys Asn Thr Ala Arg Ala Tyr His Leu
 385                 390                 395                 400
 Gln Asp Asp Gly Thr Gln Thr Val Arg Met Val Ser His Phe Tyr Gly
                 405                 410                 415    
 Asn Gly Asp Ile Cys Asp Ile Thr Asp Lys Pro Arg Gln Val Thr Val
             420                 425                 430        
 Lys Leu Lys Cys Lys Glu Ser Asp Ser Pro His Ala Val Thr Val Tyr
         435                 440                 445            
 Met Leu Glu Pro His Ser Cys Gln Tyr Ile Leu Gly Val Glu Ser Pro
     450                 455                 460                
 Val Ile Cys Lys Ile Leu Asp Thr Ala Asp Glu Asn Gly Leu Leu Ser
 465                 470                 475                 480
 Leu Pro Asn
            



      <210> 311
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 311
 Met Gly Leu Thr Leu Pro Ser Pro Arg Leu Glu Cys Gly Gly Thr Ile
   1               5                  10                  15    
 Met Ala His Cys Ser Leu Glu Leu Leu Ser Ser Ser His Pro Pro Thr
              20                  25                  30        
 Ser Ala Phe Arg Val Ala Gly Thr Ala Gly Val Ser His His Ala Trp
          35                  40                  45            
 Leu Ile Cys Leu Phe Lys Phe Phe Ile Glu Thr Glu Ser Gln Leu Tyr
      50                  55                  60                
 Cys Pro Gly Trp Lys Arg Thr Ser Phe Pro Pro Ser Asp Asn Leu Phe
  65                  70                  75                  80
 Gln Thr Ser Gln Leu Lys Asn
                  85        



      <210> 312
      <211> 68
      <212> PRT
      <213> Homo sapiens


      <400> 312
 Met Phe Asn Trp Asn Leu Trp Leu Thr Thr Leu Ile Thr Gly Leu Ala
   1               5                  10                  15    
 Gly Pro Leu Leu Leu Leu Leu Leu Gly Leu Val Phe Gly Pro Cys Ile
              20                  25                  30        
 Leu Asn Trp Phe Leu Lys Phe Ile Lys Gln Phe Ile Ala Ser Val Lys
          35                  40                  45            
 Leu Thr Tyr Leu Lys Thr Gln Tyr Asn Ser Leu Val Val Thr Glu Glu
      50                  55                  60                
 Ser Met Ile
  65        



      <210> 313
      <211> 80
      <212> PRT
      <213> Homo sapiens


      <400> 313
 Met Ser Asp Ala Asp Val Glu Lys Ala Ala Lys Asp Val Thr His Leu
   1               5                  10                  15    
 Lys Thr Ile Pro Ser Asp Glu Glu Met Leu Leu Ile Tyr Gly His Tyr
              20                  25                  30        
 Tyr Gln Ala Thr Gly Gly Asp Ile Asn Thr Glu Arg Ala Gly Met Leu
          35                  40                  45            
 Asp Phe Thr Gly Asn Asp Thr Trp Asp Ala Trp Asn Glu Leu Lys Gly
      50                  55                  60                
 Thr Ser Lys Glu Asp Ala Met Leu Ala Tyr Ile Ser Lys Val Val
  65                  70                  75                



      <210> 314
      <211> 190
      <212> PRT
      <213> Homo sapiens


      <400> 314
 Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys
   1               5                  10                  15    
 Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr
              20                  25                  30        
 Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly
          35                  40                  45            
 Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr
      50                  55                  60                
 Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys
  65                  70                  75                  80
 Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr
                  85                  90                  95    
 Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val
             100                 105                 110        
 Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys
         115                 120                 125            
 Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr
     130                 135                 140                
 Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val
 145                 150                 155                 160
 Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp
                 165                 170                 175    
 Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met
             180                 185                



      <210> 315
      <211> 384
      <212> PRT
      <213> Homo sapiens


      <400> 315
 Met Asp Arg Thr Cys Glu Glu Arg Pro Ala Glu Asp Gly Ser Asp Glu
   1               5                  10                  15    
 Glu Asp Pro Asp Ser Met Glu Ala Pro Thr Arg Ile Arg Asp Thr Pro
              20                  25                  30        
 Glu Asp Ile Val Leu Glu Ala Pro Ala Ser Gly Leu Ala Phe His Pro
          35                  40                  45            
 Ala Arg Asp Leu Leu Ala Ala Gly Asp Val Asp Gly Asp Val Phe Val
      50                  55                  60                
 Phe Ser Tyr Ser Cys Gln Glu Gly Glu Thr Lys Glu Leu Trp Ser Ser
  65                  70                  75                  80
 Gly His His Leu Lys Ala Cys Arg Ala Val Ala Phe Ser Glu Asp Gly
                  85                  90                  95    
 Gln Lys Leu Ile Thr Val Ser Lys Asp Lys Ala Ile His Val Leu Asp
             100                 105                 110        
 Val Glu Gln Gly Gln Leu Glu Arg Arg Val Ser Lys Ala His Gly Ala
         115                 120                 125            
 Pro Ile Asn Ser Leu Leu Leu Val Asp Glu Asn Val Leu Ala Thr Gly
     130                 135                 140                
 Asp Asp Thr Gly Gly Ile Arg Leu Trp Asp Gln Arg Lys Glu Gly Pro
 145                 150                 155                 160
 Leu Met Asp Met Arg Gln His Glu Glu Tyr Ile Ala Asp Met Ala Leu
                 165                 170                 175    
 Asp Pro Ala Lys Lys Leu Leu Leu Thr Ala Ser Gly Asp Gly Cys Leu
             180                 185                 190        
 Gly Ile Phe Asn Ile Lys Arg Arg Arg Phe Glu Leu Leu Ser Glu Pro
         195                 200                 205            
 Gln Ser Gly Asp Leu Thr Ser Val Thr Leu Met Lys Trp Gly Lys Lys
     210                 215                 220                
 Val Ala Cys Gly Ser Ser Glu Gly Thr Ile Tyr Leu Phe Asn Trp Asn
 225                 230                 235                 240
 Gly Phe Gly Ala Thr Ser Asp Arg Phe Ala Leu Arg Ala Glu Ser Ile
                 245                 250                 255    
 Asp Cys Met Val Pro Val Thr Glu Ser Leu Leu Cys Thr Gly Ser Thr
             260                 265                 270        
 Asp Gly Val Ile Arg Ala Val Asn Ile Leu Pro Asn Arg Val Val Gly
         275                 280                 285            
 Ser Val Gly Gln His Thr Gly Glu Pro Val Glu Glu Leu Ala Leu Ser
     290                 295                 300                
 His Cys Gly Arg Phe Leu Ala Ser Ser Gly His Asp Gln Arg Leu Lys
 305                 310                 315                 320
 Phe Trp Asp Met Ala Gln Leu Arg Ala Val Val Val Asp Asp Tyr Arg
                 325                 330                 335    
 Arg Arg Lys Lys Lys Gly Gly Pro Leu Arg Ala Leu Ser Ser Lys Thr
             340                 345                 350        
 Trp Ser Thr Asp Asp Phe Phe Ala Gly Leu Arg Glu Glu Gly Glu Asp
         355                 360                 365            
 Ser Met Ala Gln Glu Glu Lys Glu Glu Thr Gly Asp Asp Ser Asp
     370                 375                 380            



      <210> 316
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 316
 Met Ala Val Ser His Ser Val Lys Glu Arg Thr Ile Ser Glu Asn Ser
   1               5                  10                  15    
 Leu Ile Ile Leu Leu Gln Gly Leu Gln Gly Arg Val Thr Thr Val Asp
              20                  25                  30        
 Leu Arg Asp Glu Ser Val Ala His Gly Arg Ile Asp Asn Val Asp Ala
          35                  40                  45            
 Phe Met Asn Ile Arg Leu Ala Lys Val Thr Tyr Thr Asp Arg Trp Gly
      50                  55                  60                
 His Gln Val Lys Leu Asp Asp Leu Phe Val Thr Gly Arg Asn Val Arg
  65                  70                  75                  80
 Tyr Val His Ile Pro Asp Asp Val Asn Ile Thr Ser Thr Ile Glu Gln
                  85                  90                  95    
 Gln Leu Gln Ile Ile His Arg Val Arg Asn Phe Gly Gly Lys Gly Gln
             100                 105                 110        
 Gly Arg Trp Glu Phe Pro Pro Lys Asn Cys Lys
         115                 120            



      <210> 317
      <211> 173
      <212> PRT
      <213> Homo sapiens


      <400> 317
 Met Lys Ile Tyr Lys Asp Leu Ile Thr Asp Asp Glu Leu Phe Ser Asp
   1               5                  10                  15    
 Thr Tyr Pro Met Lys Leu Ile Asp Gly Val Ile Tyr Glu Val Thr Gly
              20                  25                  30        
 Arg Leu Val Thr Arg Lys Val Gly Asp Val Gln Leu Ile Gly Ser Asn
          35                  40                  45            
 Pro Ser Ala Glu Asp Val Asp Glu Gly Thr Glu Glu Ala Val Glu Ser
      50                  55                  60                
 Gly Cys Asp Ile Val Leu Asn His Arg Leu Gln Glu Ser Tyr Ala Phe
  65                  70                  75                  80
 Gly Asp Lys Lys Gly Tyr Thr Leu Tyr Leu Lys Glu Tyr Met Lys Arg
                  85                  90                  95    
 Ile Val Asp Lys Leu Gln Glu Thr Asn Pro Ser Glu Val Asp Thr Phe
             100                 105                 110        
 Lys Thr Asn Ile Asn Lys Tyr Met Lys Asp Val Leu Gly Arg Phe Lys
         115                 120                 125            
 Asp Leu Gln Phe Phe Thr Gly Glu Ser Thr Asp Ile Asp Gly Met Val
     130                 135                 140                
 Ala Leu Leu Glu Tyr Arg Asp Leu Asn Gly Glu Ser Arg Pro Val Met
 145                 150                 155                 160
 Met Phe Phe Lys His Gly Leu Ile Gln Glu Lys Cys
                 165                 170        



      <210> 318
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 318
 Met Leu Arg Asn Leu Leu Ala Leu Arg Gln Ile Ala Gln Arg Thr Ile
   1               5                  10                  15    
 Ser Thr Thr Ser Arg Arg His Phe Glu Asn Lys Val Pro Glu Lys Gln
              20                  25                  30        
 Lys Leu Phe Gln Glu Asp Asn Gly Met Pro Val His Leu Lys Gly Gly
          35                  40                  45            
 Ala Ser Asp Ala Leu Leu Tyr Arg Ala Thr Met Ala Leu Thr Leu Gly
      50                  55                  60                
 Gly Thr Ala Tyr Ala Ile Tyr Leu Leu Ala Met Ala Ala Phe Pro Lys
  65                  70                  75                  80
 Lys Gln Asn
            



      <210> 319
      <211> 347
      <212> PRT
      <213> Homo sapiens


      <400> 319
 Met Val Gly Gly Gly Gly Lys Arg Arg Pro Gly Gly Glu Gly Pro Gln
   1               5                  10                  15    
 Cys Glu Lys Thr Thr Asp Val Lys Lys Ser Lys Phe Cys Glu Ala Asp
              20                  25                  30        
 Val Ser Ser Asp Leu Arg Lys Glu Val Glu Asn His Tyr Lys Leu Ser
          35                  40                  45            
 Leu Pro Glu Asp Phe Tyr His Phe Trp Lys Phe Cys Glu Glu Leu Asp
      50                  55                  60                
 Pro Glu Lys Pro Ser Asp Ser Leu Ser Ala Ser Leu Gly Leu Gln Leu
  65                  70                  75                  80
 Val Gly Pro Tyr Asp Ile Leu Ala Gly Lys His Lys Thr Lys Lys Lys
                  85                  90                  95    
 Ser Thr Gly Leu Asn Phe Asn Leu His Trp Arg Phe Tyr Tyr Asp Pro
             100                 105                 110        
 Pro Glu Phe Gln Thr Ile Ile Ile Gly Asp Asn Lys Thr Gln Tyr His
         115                 120                 125            
 Met Gly Tyr Phe Arg Asp Ser Pro Asp Glu Phe Pro Val Tyr Val Gly
     130                 135                 140                
 Ile Asn Glu Ala Lys Lys Asn Cys Ile Ile Val Pro Asn Gly Asp Asn
 145                 150                 155                 160
 Val Phe Ala Ala Val Lys Leu Phe Leu Thr Lys Lys Leu Lys Glu Ile
                 165                 170                 175    
 Thr Asp Lys Lys Lys Ile Asn Leu Leu Lys Asn Ile Asp Glu Lys Leu
             180                 185                 190        
 Thr Glu Ala Ala Arg Glu Leu Gly Tyr Ser Leu Glu Gln Arg Thr Val
         195                 200                 205            
 Lys Met Lys Gln Arg Asp Lys Lys Val Val Thr Lys Thr Phe His Gly
     210                 215                 220                
 Ala Gly Leu Val Val Pro Val Asp Lys Asn Asp Val Gly Tyr Arg Glu
 225                 230                 235                 240
 Leu Pro Glu Thr Asp Ala Asp Leu Lys Arg Ile Cys Lys Thr Ile Val
                 245                 250                 255    
 Glu Ala Ala Ser Asp Glu Glu Arg Leu Lys Ala Phe Ala Pro Ile Gln
             260                 265                 270        
 Glu Met Met Thr Phe Val Gln Phe Ala Asn Asp Glu Cys Asp Tyr Gly
         275                 280                 285            
 Met Gly Leu Glu Leu Gly Met Asp Leu Phe Cys Tyr Gly Ser His Tyr
     290                 295                 300                
 Phe His Lys Val Ala Gly Gln Leu Leu Pro Leu Ala Tyr Asn Leu Leu
 305                 310                 315                 320
 Lys Arg Asn Leu Phe Ala Glu Ile Ile Glu Glu His Leu Ala Asn Arg
                 325                 330                 335    
 Ser Gln Glu Asn Ile Asp Gln Leu Ala Ala
             340                 345    



      <210> 320
      <211> 280
      <212> PRT
      <213> Homo sapiens


      <400> 320
 Met Ala Ala Pro Val Arg Arg Thr Leu Leu Gly Val Ala Gly Gly Trp
   1               5                  10                  15    
 Arg Arg Phe Glu Arg Leu Trp Ala Gly Ser Leu Ser Ser Arg Ser Leu
              20                  25                  30        
 Ala Leu Ala Ala Ala Pro Ser Ser Asn Gly Ser Pro Trp Arg Leu Leu
          35                  40                  45            
 Gly Ala Leu Cys Leu Gln Arg Pro Pro Val Val Ser Lys Pro Leu Thr
      50                  55                  60                
 Pro Leu Gln Glu Glu Met Ala Ser Leu Leu Gln Gln Ile Glu Ile Glu
  65                  70                  75                  80
 Arg Ser Leu Tyr Ser Asp His Glu Leu Arg Ala Leu Asp Glu Asn Gln
                  85                  90                  95    
 Arg Leu Ala Lys Lys Lys Ala Asp Leu His Asp Glu Glu Asp Glu Gln
             100                 105                 110        
 Asp Ile Leu Leu Ala Gln Asp Leu Glu Asp Met Trp Glu Gln Lys Phe
         115                 120                 125            
 Leu Gln Phe Lys Leu Gly Ala Arg Ile Thr Glu Ala Asp Glu Lys Asn
     130                 135                 140                
 Asp Arg Thr Ser Leu Asn Arg Lys Leu Asp Arg Asn Leu Val Leu Leu
 145                 150                 155                 160
 Val Arg Glu Lys Phe Gly Asp Gln Asp Val Trp Ile Leu Pro Gln Ala
                 165                 170                 175    
 Glu Trp Gln Pro Gly Glu Thr Leu Arg Gly Thr Ala Glu Arg Thr Leu
             180                 185                 190        
 Ala Thr Leu Ser Glu Asn Asn Met Glu Ala Lys Phe Leu Gly Asn Ala
         195                 200                 205            
 Pro Cys Gly His Tyr Thr Phe Lys Phe Pro Gln Ala Met Arg Thr Glu
     210                 215                 220                
 Ser Asn Leu Gly Ala Lys Val Phe Phe Phe Lys Ala Leu Leu Leu Thr
 225                 230                 235                 240
 Gly Asp Phe Ser Gln Ala Gly Asn Lys Gly His His Val Trp Val Thr
                 245                 250                 255    
 Lys Asp Glu Leu Gly Asp Tyr Leu Lys Pro Lys Tyr Leu Ala Gln Val
             260                 265                 270        
 Arg Arg Phe Val Ser Asp Leu
         275                



      <210> 321
      <211> 201
      <212> PRT
      <213> Homo sapiens


      <400> 321
 Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys
   1               5                  10                  15    
 Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala
              20                  25                  30        
 Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn
          35                  40                  45            
 Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln
      50                  55                  60                
 Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser
  65                  70                  75                  80
 Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr
                  85                  90                  95    
 His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro
             100                 105                 110        
 Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn
         115                 120                 125            
 Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu
     130                 135                 140                
 Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys
 145                 150                 155                 160
 Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp His Arg Arg
                 165                 170                 175    
 Gly Gln Glu Thr Asp Gln Arg Leu Arg Gly Glu Gly Tyr Ser Arg Glu
             180                 185                 190        
 Asn Cys Gly Phe Gly Gln Gly Ala
         195                 200



      <210> 322
      <211> 191
      <212> PRT
      <213> Homo sapiens


      <400> 322
 Met Thr Asp Gly Gln Leu Arg Ser Lys Arg Asp Glu Phe Trp Asp Thr
   1               5                  10                  15    
 Ala Pro Ala Phe Glu Gly Arg Lys Glu Ile Trp Asp Ala Leu Lys Ala
              20                  25                  30        
 Ala Ala His Ala Phe Glu Ser Asn Asp His Glu Leu Ala Gln Ala Ile
          35                  40                  45            
 Ile Asp Gly Ala Asn Ile Thr Leu Pro His Gly Ala Leu Thr Glu Cys
      50                  55                  60                
 Tyr Asp Glu Leu Gly Asn Arg Tyr Gln Leu Pro Val Tyr Cys Leu Ala
  65                  70                  75                  80
 Pro Pro Ile Asn Met Ile Glu Glu Lys Ser Asp Ile Glu Thr Leu Asp
                  85                  90                  95    
 Ile Pro Glu Pro Pro Pro Asn Ser Gly Tyr Glu Cys Gln Leu Arg Leu
             100                 105                 110        
 Arg Leu Ser Thr Gly Lys Asp Leu Lys Leu Val Val Arg Ser Thr Asp
         115                 120                 125            
 Thr Val Phe His Met Lys Arg Arg Leu His Ala Ala Glu Gly Val Glu
     130                 135                 140                
 Pro Gly Ser Gln Arg Trp Phe Phe Ser Gly Arg Pro Leu Thr Asp Lys
 145                 150                 155                 160
 Met Lys Phe Glu Glu Leu Lys Ile Pro Lys Asp Tyr Val Val Gln Val
                 165                 170                 175    
 Ile Val Ser Gln Pro Val Gln Asn Pro Thr Pro Val Glu Asn
             180                 185                 190



      <210> 323
      <211> 206
      <212> PRT
      <213> Homo sapiens


      <400> 323
 Met Glu Gly Asn Gly Pro Ala Ala Val His Tyr Gln Pro Ala Ser Pro
   1               5                  10                  15    
 Pro Arg Asp Ala Cys Val Tyr Ser Ser Cys Tyr Cys Glu Glu Asn Ile
              20                  25                  30        
 Trp Lys Leu Cys Glu Tyr Ile Lys Asn His Asp Gln Tyr Pro Leu Glu
          35                  40                  45            
 Glu Cys Tyr Ala Val Phe Ile Ser Asn Glu Arg Lys Met Ile Pro Ile
      50                  55                  60                
 Trp Lys Gln Gln Ala Arg Pro Gly Asp Gly Pro Val Ile Trp Asp Tyr
  65                  70                  75                  80
 His Val Val Leu Leu His Val Ser Ser Gly Gly Gln Asn Phe Ile Tyr
                  85                  90                  95    
 Asp Leu Asp Thr Val Leu Pro Phe Pro Cys Leu Phe Asp Thr Tyr Val
             100                 105                 110        
 Glu Asp Ala Phe Lys Ser Asp Asp Asp Ile His Pro Gln Phe Arg Arg
         115                 120                 125            
 Lys Phe Arg Val Ile Arg Ala Asp Ser Tyr Leu Lys Asn Phe Ala Ser
     130                 135                 140                
 Asp Arg Ser His Met Lys Asp Ser Ser Gly Asn Trp Arg Glu Pro Pro
 145                 150                 155                 160
 Pro Pro Tyr Pro Cys Ile Glu Thr Gly Asp Ser Lys Met Asn Leu Asn
                 165                 170                 175    
 Asp Phe Ile Ser Met Asp Pro Lys Val Gly Trp Gly Ala Val Tyr Thr
             180                 185                 190        
 Leu Ser Glu Phe Thr His Arg Phe Gly Ser Lys Asn Cys
         195                 200                 205



      <210> 324
      <211> 68
      <212> PRT
      <213> Homo sapiens


      <400> 324
 Met Gly Lys Gly Met Val Ala Met Leu Ile Leu Gly Leu Leu Leu Leu
   1               5                  10                  15    
 Ala Leu Leu Leu Pro Val Gln Val Ser Ser Phe Val Pro Leu Thr Ser
              20                  25                  30        
 Met Pro Glu Ala Thr Ala Ala Glu Thr Thr Lys Pro Ser Asn Ser Ala
          35                  40                  45            
 Leu Gln Pro Thr Ala Gly Leu Leu Val Val Leu Leu Ala Leu Leu His
      50                  55                  60                
 Leu Tyr His
  65        



      <210> 325
      <211> 238
      <212> PRT
      <213> Homo sapiens


      <400> 325
 Met Asp Lys Val Cys Ala Val Phe Gly Gly Ser Arg Gly Ile Gly Arg
   1               5                  10                  15    
 Ala Val Ala Gln Leu Met Ala Arg Lys Gly Tyr Arg Leu Ala Val Ile
              20                  25                  30        
 Ala Arg Asn Leu Glu Gly Ala Lys Ala Ala Ala Gly Asp Leu Gly Gly
          35                  40                  45            
 Asp His Leu Ala Phe Ser Cys Asp Val Ala Lys Glu His Asp Val Gln
      50                  55                  60                
 Asn Thr Phe Glu Glu Met Glu Lys His Leu Gly Arg Val Asn Phe Leu
  65                  70                  75                  80
 Val Asn Ala Ala Gly Ile Asn Arg Asp Gly Leu Leu Val Arg Thr Lys
                  85                  90                  95    
 Thr Glu Asp Met Val Ser Gln Leu His Thr Asn Leu Leu Gly Ser Met
             100                 105                 110        
 Leu Thr Cys Lys Ala Ala Met Arg Thr Met Ile Gln Gln Gln Gly Gly
         115                 120                 125            
 Ser Ile Val Asn Val Gly Ser Ile Val Gly Leu Lys Gly Asn Ser Gly
     130                 135                 140                
 Gln Ser Val Tyr Ser Ala Ser Lys Gly Gly Leu Val Gly Phe Ser Arg
 145                 150                 155                 160
 Ala Leu Ala Lys Glu Val Ala Arg Lys Lys Ile Arg Val Asn Val Val
                 165                 170                 175    
 Ala Pro Gly Phe Val His Thr Asp Met Thr Lys Asp Leu Lys Glu Glu
             180                 185                 190        
 His Leu Lys Lys Asn Ile Pro Leu Gly Arg Phe Gly Glu Thr Ile Glu
         195                 200                 205            
 Val Ala His Ala Val Val Phe Leu Leu Glu Ser Pro Tyr Ile Thr Gly
     210                 215                 220                
 His Val Leu Val Val Asp Gly Gly Leu Gln Leu Ile Leu
 225                 230                 235        



      <210> 326
      <211> 197
      <212> PRT
      <213> Homo sapiens


      <400> 326
 Met Leu Leu Lys Met Ile Phe Val Asp Asn Phe Val His Ala Asp Leu
   1               5                  10                  15    
 His Pro Gly Asn Ile Leu Val Gln Gly Ala Asn Gly Leu Ser Ser Ser
              20                  25                  30        
 Gln Glu Ala Gln Leu Gln Gln Ala Asp Ile Cys Asp Thr Leu Val Val
          35                  40                  45            
 Ala Val Pro Ser Ser Leu Cys Pro Leu Arg Leu Val Leu Leu Asp Ala
      50                  55                  60                
 Gly Ile Val Ala Glu Leu Gln Ala Pro Asp Leu Arg Asn Phe Arg Ala
  65                  70                  75                  80
 Val Phe Met Ala Val Val Met Gly Gln Gly Gln Arg Val Ala Glu Leu
                  85                  90                  95    
 Ile Leu His His Ala Arg Ala Ser Glu Cys Arg Asp Val Glu Gly Phe
             100                 105                 110        
 Lys Thr Glu Met Ala Met Leu Val Thr Gln Ala Arg Lys Asn Thr Ile
         115                 120                 125            
 Thr Leu Glu Lys Leu His Val Ser Ser Leu Leu Ser Ser Val Phe Lys
     130                 135                 140                
 Leu Leu Met Thr His Lys Val Lys Leu Glu Ser Asn Phe Ala Ser Ile
 145                 150                 155                 160
 Val Phe Ala Ile Met Val Leu Glu Gly Leu Gly Arg Ser Leu Asp Pro
                 165                 170                 175    
 Lys Leu Asp Ile Leu Glu Ala Ala Arg Pro Phe Leu Leu Thr Gly Pro
             180                 185                 190        
 Val Cys Pro Pro
         195    



      <210> 327
      <211> 244
      <212> PRT
      <213> Homo sapiens


      <400> 327
 Met Thr Thr Leu Thr His Arg Ala Arg Arg Thr Glu Ile Ser Lys Asn
   1               5                  10                  15    
 Ser Glu Lys Lys Met Glu Ser Glu Glu Asp Ser Asn Trp Glu Lys Ser
              20                  25                  30        
 Pro Asp Asn Glu Asp Ser Gly Asp Ser Lys Asp Ile Arg Leu Thr Leu
          35                  40                  45            
 Met Glu Glu Val Leu Leu Leu Gly Leu Lys Asp Lys Glu Gly Tyr Thr
      50                  55                  60                
 Ser Phe Trp Asn Asp Cys Ile Ser Ser Gly Leu Arg Gly Gly Ile Leu
  65                  70                  75                  80
 Ile Glu Leu Ala Met Arg Gly Arg Ile Tyr Leu Glu Pro Pro Thr Met
                  85                  90                  95    
 Arg Lys Lys Arg Leu Leu Asp Arg Lys Val Leu Leu Lys Ser Asp Ser
             100                 105                 110        
 Pro Thr Gly Asp Val Leu Leu Asp Glu Thr Leu Lys His Ile Lys Ala
         115                 120                 125            
 Thr Glu Pro Thr Glu Thr Val Gln Thr Trp Ile Glu Leu Leu Thr Gly
     130                 135                 140                
 Glu Thr Trp Asn Pro Phe Lys Leu Gln Tyr Gln Leu Arg Asn Val Arg
 145                 150                 155                 160
 Glu Arg Ile Ala Lys Asn Leu Val Glu Lys Gly Ile Leu Thr Thr Glu
                 165                 170                 175    
 Lys Gln Asn Phe Leu Leu Phe Asp Met Thr Thr His Pro Val Thr Asn
             180                 185                 190        
 Thr Thr Glu Lys Gln Arg Leu Val Lys Lys Leu Gln Asp Ser Val Leu
         195                 200                 205            
 Glu Arg Trp Val Asn Asp Pro Gln Arg Met Asp Lys Arg Thr Leu Ala
     210                 215                 220                
 Leu Leu Val Leu Ala His Ser Ser Asp Val Leu Glu Asn Val Phe Ser
 225                 230                 235                 240
 Ser Leu Thr
            



      <210> 328
      <211> 429
      <212> PRT
      <213> Homo sapiens


      <400> 328
 Met Ser Tyr Tyr Leu Ser Ser Glu Asn His Leu Asp Pro Gly Pro Ile
   1               5                  10                  15    
 Tyr Met Arg Glu Asn Gly Gln Leu His Met Val Asn Leu Ala Leu Asp
              20                  25                  30        
 Gly Val Arg Ser Ser Leu Gln Lys Pro Arg Pro Phe Arg Leu Phe Pro
          35                  40                  45            
 Lys Gly Phe Ser Val Glu Leu Cys Met Asn Arg Glu Asp Asp Thr Ala
      50                  55                  60                
 Arg Lys Glu Lys Thr Asp His Phe Ile Phe Thr Tyr Thr Arg Glu Gly
  65                  70                  75                  80
 Asn Leu Arg Tyr Ser Ala Lys Ser Leu Phe Ser Leu Val Leu Gly Phe
                  85                  90                  95    
 Ile Ser Asp Asn Val Asp His Ile Asp Ser Leu Ile Gly Phe Pro Glu
             100                 105                 110        
 Gln Ile Ala Glu Lys Leu Phe Ser Ala Ala Glu Ala Arg Gln Lys Phe
         115                 120                 125            
 Thr Glu Pro Gly Ala Gly Leu Arg Ala Leu Gln Lys Phe Thr Glu Ala
     130                 135                 140                
 Tyr Gly Ser Leu Val Leu Cys Ser Leu Cys Leu Arg Asn Arg Tyr Leu
 145                 150                 155                 160
 Val Ile Ser Glu Lys Leu Glu Glu Ile Lys Ser Phe Arg Glu Leu Thr
                 165                 170                 175    
 Cys Leu Asp Leu Ser Cys Cys Lys Leu Gly Asp Glu His Glu Leu Leu
             180                 185                 190        
 Glu His Leu Thr Asn Glu Ala Leu Ser Ser Val Thr Gln Leu His Leu
         195                 200                 205            
 Lys Asp Asn Cys Leu Ser Asp Ala Gly Val Arg Lys Met Thr Ala Pro
     210                 215                 220                
 Val Arg Val Met Lys Arg Gly Leu Glu Asn Leu Thr Leu Leu Asp Leu
 225                 230                 235                 240
 Ser Cys Asn Pro Glu Ile Thr Asp Ala Gly Ile Gly Tyr Leu Phe Phe
                 245                 250                 255    
 Phe Arg Lys Leu Asn Cys Leu Asp Ile Ser Gly Thr Gly Leu Lys Asp
             260                 265                 270        
 Ile Lys Thr Val Lys His Lys Leu Gln Thr His Ile Gly Leu Val His
         275                 280                 285            
 Ser Lys Val Pro Leu Lys Glu Phe Asp His Ser Asn Cys Lys Thr Glu
     290                 295                 300                
 Gly Trp Ala Asp Gln Ile Val Leu Gln Trp Glu Arg Val Thr Ala Glu
 305                 310                 315                 320
 Ala Val Lys Pro Arg Glu Thr Ser Glu Pro Arg Ala Ala Ala Gln Arg
                 325                 330                 335    
 Phe Tyr Gly Lys Arg Ser Arg Ala Glu Ala Pro Leu Lys Cys Pro Leu
             340                 345                 350        
 Ala Asp Thr His Met Asn Ser Ser Glu Lys Leu Gln Phe Tyr Lys Glu
         355                 360                 365            
 Lys Ala Pro Asp Cys His Gly Pro Val Leu Lys His Glu Ala Ile Ser
     370                 375                 380                
 Ser Gln Glu Ser Lys Lys Ser Lys Lys Arg Pro Phe Glu Glu Ser Glu
 385                 390                 395                 400
 Thr Glu Gln Asn Asn Ser Ser Gln Pro Ser Lys Gln Lys Tyr Val Cys
                 405                 410                 415    
 Leu Ala Val Glu Asp Trp Asp Leu Leu Asn Ser Tyr
             420                 425            



      <210> 329
      <211> 109
      <212> PRT
      <213> Homo sapiens


      <400> 329
 Met Ala Ala Pro Cys Leu Leu Arg Gln Gly Arg Ala Gly Ala Leu Lys
   1               5                  10                  15    
 Thr Met Leu Gln Glu Ala Gln Val Phe Arg Gly Leu Ala Ser Thr Val
              20                  25                  30        
 Ser Leu Ser Ala Glu Ser Gly Lys Ser Glu Lys Gly Gln Pro Gln Asn
          35                  40                  45            
 Ser Lys Lys Gln Ser Pro Pro Lys Lys Pro Ala Pro Val Pro Ala Glu
      50                  55                  60                
 Pro Phe Asp Asn Thr Thr Tyr Lys Asn Leu Gln His His Asp Tyr Ser
  65                  70                  75                  80
 Thr Tyr Thr Phe Leu Asp Leu Asn Leu Glu Leu Ser Lys Phe Arg Met
                  85                  90                  95    
 Pro Gln Pro Ser Ser Gly Arg Glu Ser Pro Arg His
             100                 105            



      <210> 330
      <211> 130
      <212> PRT
      <213> Homo sapiens


      <400> 330
 Met Ala Ala Pro Cys Leu Leu Arg Gln Gly Arg Ala Gly Ala Leu Lys
   1               5                  10                  15    
 Thr Met Leu Gln Glu Ala Gln Val Phe Arg Gly Leu Ala Ser Thr Val
              20                  25                  30        
 Ser Leu Ser Ala Glu Ser Gly Lys Ser Glu Lys Gly Gln Pro Gln Asn
          35                  40                  45            
 Ser Lys Lys Gln Ser Pro Pro Lys Ser Val Pro Thr Pro His Arg Arg
      50                  55                  60                
 Tyr Ser Pro Cys Gly Asp Trp Lys Asp Ala Ser Ser Leu Lys Pro Ala
  65                  70                  75                  80
 Pro Val Pro Ala Glu Pro Phe Asp Asn Thr Thr Tyr Lys Asn Leu Gln
                  85                  90                  95    
 His His Asp Tyr Ser Thr Tyr Thr Phe Leu Asp Leu Asn Leu Glu Leu
             100                 105                 110        
 Ser Lys Phe Arg Met Pro Gln Pro Ser Ser Gly Arg Glu Ser Pro Arg
         115                 120                 125            
 His
    



      <210> 331
      <211> 39
      <212> PRT
      <213> Homo sapiens


      <400> 331
 Met Lys Val Arg Ala Ser Val Lys Lys Leu Cys Arg Asn Cys Lys Ile
   1               5                  10                  15    
 Val Lys Arg Asp Gly Val Ile Arg Val Ile Cys Ser Ala Glu Pro Lys
              20                  25                  30        
 His Lys Gln Arg Gln Gly
          35            



      <210> 332
      <211> 66
      <212> PRT
      <213> Homo sapiens


      <400> 332
 Met Asp Asp Ile Leu Val Thr Ser Asp Leu Thr Ser Arg Tyr Lys Ile
   1               5                  10                  15    
 Ser Arg Lys Thr Leu Trp Ser Trp Gln Ser Ala Asp Thr Met Pro Arg
              20                  25                  30        
 Gly Phe Val Cys Pro Phe Pro Pro Pro Asp Trp Pro Gly Asn Pro Asn
          35                  40                  45            
 Arg Trp Arg Ser Glu Ser Ile Lys Glu Trp Glu Asp Lys Lys Lys Ile
      50                  55                  60                
 Asn
  65



      <210> 333
      <211> 182
      <212> PRT
      <213> Homo sapiens


      <400> 333
 Met Phe Lys Lys Phe Asp Glu Lys Glu Ser Val Ser Asn Cys Ile Gln
   1               5                  10                  15    
 Leu Lys Thr Ser Val Ile Lys Gly Ile Lys Ser Gln Leu Val Glu Gln
              20                  25                  30        
 Phe Pro Gly Ile Glu Pro Trp Leu Asn Gln Ile Met Pro Lys Lys Asp
          35                  40                  45            
 Pro Val Lys Ile Val Arg Cys His Glu His Thr Glu Ile Leu Thr Val
      50                  55                  60                
 Ser Gly Glu Leu Leu Phe Phe Arg Gln Arg Lys Gly Pro Phe Cys Pro
  65                  70                  75                  80
 Thr Leu Arg Leu Leu His Lys Tyr Pro Phe Ile Leu Pro His Gln Gln
                  85                  90                  95    
 Val Asp Lys Gly Ala Ile Lys Phe Val Leu Ser Gly Ala Asn Ile Met
             100                 105                 110        
 Cys Pro Gly Leu Thr Ser Pro Gly Ala Lys Leu Tyr Pro Ala Ala Val
         115                 120                 125            
 Asp Thr Ile Val Ala Val Thr Ala Glu Gly Lys Gln His Ala Leu Cys
     130                 135                 140                
 Val Gly Val Met Lys Met Ser Ala Glu Asp Ile Glu Lys Val Asn Lys
 145                 150                 155                 160
 Gly Ile Gly Ile Glu Asn Ile His Tyr Leu Asn Asp Gly Leu Trp His
                 165                 170                 175    
 Met Lys Thr Tyr Lys
             180    



      <210> 334
      <211> 287
      <212> PRT
      <213> Homo sapiens


      <400> 334
 Met Ser Leu Pro Ile Gly Ile Tyr Arg Arg Ala Val Ser Tyr Asp Asp
   1               5                  10                  15    
 Thr Leu Glu Asp Pro Ala Pro Met Thr Pro Pro Pro Ser Asp Met Gly
              20                  25                  30        
 Ser Val Pro Trp Lys Pro Val Ile Pro Glu Arg Lys Tyr Gln His Leu
          35                  40                  45            
 Ala Lys Val Glu Glu Gly Glu Ala Ser Leu Pro Ser Pro Ala Met Thr
      50                  55                  60                
 Leu Ser Ser Ala Ile Asp Ser Val Asp Lys Val Pro Val Val Lys Ala
  65                  70                  75                  80
 Lys Ala Thr His Val Ile Met Asn Ser Leu Ile Thr Lys Gln Thr Gln
                  85                  90                  95    
 Glu Ser Ile Gln His Phe Glu Arg Gln Ala Gly Leu Arg Asp Ala Gly
             100                 105                 110        
 Tyr Thr Pro His Lys Gly Leu Thr Thr Glu Glu Thr Lys Tyr Leu Arg
         115                 120                 125            
 Val Ala Glu Ala Leu His Lys Leu Lys Leu Gln Ser Gly Glu Val Thr
     130                 135                 140                
 Lys Glu Glu Arg Gln Pro Ala Ser Ala Gln Ser Thr Pro Ser Thr Thr
 145                 150                 155                 160
 Pro His Ser Ser Pro Lys Gln Arg Pro Arg Gly Trp Phe Thr Ser Gly
                 165                 170                 175    
 Ser Ser Thr Ala Leu Pro Gly Pro Asn Pro Ser Thr Met Asp Ser Gly
             180                 185                 190        
 Ser Gly Asp Lys Asp Arg Asn Leu Ser Asp Lys Trp Ser Leu Phe Gly
         195                 200                 205            
 Pro Arg Ser Leu Gln Lys Tyr Asp Ser Gly Ser Phe Ala Thr Gln Ala
     210                 215                 220                
 Tyr Arg Gly Ala Gln Lys Pro Ser Pro Leu Glu Leu Ile Arg Ala Gln
 225                 230                 235                 240
 Ala Asn Arg Met Ala Glu Asp Pro Ala Ala Leu Lys Pro Pro Lys Met
                 245                 250                 255    
 Asp Ile Pro Val Met Glu Gly Lys Lys Gln Pro Pro Arg Ala His Asn
             260                 265                 270        
 Leu Lys Pro Arg Asp Leu Asn Val Leu Thr Pro Thr Gly Phe
         275                 280                 285    



      <210> 335
      <211> 1638
      <212> PRT
      <213> Homo sapiens


      <400> 335
 Met Cys Thr Ala Glu Gln Phe Arg Cys His Ser Gly Arg Cys Val Arg
   1               5                  10                  15    
 Leu Ser Trp Arg Cys Asp Gly Glu Asp Asp Cys Ala Asp Asn Ser Asp
              20                  25                  30        
 Glu Glu Asn Cys Glu Asn Thr Gly Ser Pro Gln Cys Ala Leu Asp Gln
          35                  40                  45            
 Phe Leu Cys Trp Asn Gly Arg Cys Ile Gly Gln Arg Lys Leu Cys Asn
      50                  55                  60                
 Gly Val Asn Asp Cys Gly Asp Asn Ser Asp Glu Ser Pro Gln Gln Asn
  65                  70                  75                  80
 Cys Arg Pro Arg Thr Gly Glu Glu Asn Cys Asn Val Asn Asn Gly Gly
                  85                  90                  95    
 Cys Ala Gln Lys Cys Gln Met Val Arg Gly Ala Val Gln Cys Thr Cys
             100                 105                 110        
 His Thr Gly Tyr Arg Leu Thr Glu Asp Gly His Thr Cys Gln Asp Val
         115                 120                 125            
 Asn Glu Cys Ala Glu Glu Gly Tyr Cys Ser Gln Gly Cys Thr Asn Ser
     130                 135                 140                
 Glu Gly Ala Phe Gln Cys Trp Cys Glu Thr Gly Tyr Glu Leu Arg Pro
 145                 150                 155                 160
 Asp Arg Arg Ser Cys Lys Ala Leu Gly Pro Glu Pro Val Leu Leu Phe
                 165                 170                 175    
 Ala Asn Arg Ile Asp Ile Arg Gln Val Leu Pro His Arg Ser Glu Tyr
             180                 185                 190        
 Thr Leu Leu Leu Asn Asn Leu Glu Asn Ala Ile Ala Leu Asp Phe His
         195                 200                 205            
 His Arg Arg Glu Leu Val Phe Trp Ser Asp Val Thr Leu Asp Arg Ile
     210                 215                 220                
 Leu Arg Ala Asn Leu Asn Gly Ser Asn Val Glu Glu Val Val Ser Thr
 225                 230                 235                 240
 Gly Leu Glu Ser Pro Gly Gly Leu Ala Val Asp Trp Val His Asp Lys
                 245                 250                 255    
 Leu Tyr Trp Thr Asp Ser Gly Thr Ser Arg Ile Glu Val Ala Asn Leu
             260                 265                 270        
 Asp Gly Ala His Arg Lys Val Leu Leu Trp Gln Asn Leu Glu Lys Pro
         275                 280                 285            
 Arg Ala Ile Ala Leu His Pro Met Glu Gly Thr Ile Tyr Trp Thr Asp
     290                 295                 300                
 Trp Gly Asn Thr Pro Arg Ile Glu Ala Ser Ser Met Asp Gly Ser Gly
 305                 310                 315                 320
 Arg Arg Ile Ile Ala Asp Thr His Leu Phe Trp Pro Asn Gly Leu Thr
                 325                 330                 335    
 Ile Asp Tyr Ala Gly Arg Arg Met Tyr Trp Val Asp Ala Lys His His
             340                 345                 350        
 Val Ile Glu Arg Ala Asn Leu Asp Gly Ser His Arg Lys Ala Val Ile
         355                 360                 365            
 Ser Gln Gly Leu Pro His Pro Phe Ala Ile Thr Val Phe Glu Asp Ser
     370                 375                 380                
 Leu Tyr Trp Thr Asp Trp His Thr Lys Ser Ile Asn Ser Ala Asn Lys
 385                 390                 395                 400
 Phe Thr Gly Lys Asn Gln Glu Ile Ile Arg Asn Lys Leu His Phe Pro
                 405                 410                 415    
 Met Asp Ile His Thr Leu His Pro Gln Arg Gln Pro Ala Gly Lys Asn
             420                 425                 430        
 Arg Cys Gly Asp Asn Asn Gly Gly Cys Thr His Leu Cys Leu Pro Ser
         435                 440                 445            
 Gly Gln Asn Tyr Thr Cys Ala Cys Pro Thr Gly Phe Arg Lys Ile Ser
     450                 455                 460                
 Ser His Ala Cys Ala Gln Ser Leu Asp Lys Phe Leu Leu Phe Ala Arg
 465                 470                 475                 480
 Arg Met Asp Ile Arg Arg Ile Ser Phe Asp Thr Glu Asp Leu Ser Asp
                 485                 490                 495    
 Asp Val Ile Pro Leu Ala Asp Val Arg Ser Ala Val Ala Leu Asp Trp
             500                 505                 510        
 Asp Ser Arg Asp Asp His Val Tyr Trp Thr Asp Val Ser Thr Asp Thr
         515                 520                 525            
 Ile Ser Arg Ala Lys Trp Asp Gly Thr Gly Gln Glu Val Val Val Asp
     530                 535                 540                
 Thr Ser Leu Glu Ser Pro Ala Gly Leu Ala Ile Asp Trp Val Thr Asn
 545                 550                 555                 560
 Lys Leu Tyr Trp Thr Asp Ala Gly Thr Asp Arg Ile Glu Val Ala Asn
                 565                 570                 575    
 Thr Asp Gly Ser Met Arg Thr Val Leu Ile Trp Glu Asn Leu Asp Arg
             580                 585                 590        
 Pro Arg Asp Ile Val Val Glu Pro Met Gly Gly Tyr Met Tyr Trp Thr
         595                 600                 605            
 Asp Trp Gly Ala Ser Pro Lys Ile Glu Arg Ala Gly Met Asp Ala Ser
     610                 615                 620                
 Gly Arg Gln Val Ile Ile Ser Ser Asn Leu Thr Trp Pro Asn Gly Leu
 625                 630                 635                 640
 Ala Ile Asp Tyr Gly Ser Gln Arg Leu Tyr Trp Ala Asp Ala Gly Met
                 645                 650                 655    
 Lys Thr Ile Glu Phe Ala Gly Leu Asp Gly Ser Lys Arg Lys Val Leu
             660                 665                 670        
 Ile Gly Ser Gln Leu Pro His Pro Phe Gly Leu Thr Leu Tyr Gly Glu
         675                 680                 685            
 Arg Ile Tyr Trp Thr Asp Trp Gln Thr Lys Ser Ile Gln Ser Ala Asp
     690                 695                 700                
 Arg Leu Thr Gly Leu Asp Arg Glu Thr Leu Gln Glu Asn Leu Glu Asn
 705                 710                 715                 720
 Leu Met Asp Ile His Val Phe His Arg Arg Arg Pro Pro Val Ser Thr
                 725                 730                 735    
 Pro Cys Ala Met Glu Asn Gly Gly Cys Ser His Leu Cys Leu Arg Ser
             740                 745                 750        
 Pro Asn Pro Ser Gly Phe Ser Cys Thr Cys Pro Thr Gly Ile Asn Leu
         755                 760                 765            
 Leu Ser Asp Gly Lys Thr Cys Ser Pro Gly Met Asn Ser Phe Leu Ile
     770                 775                 780                
 Phe Ala Arg Arg Ile Asp Ile Arg Met Val Ser Leu Asp Ile Pro Tyr
 785                 790                 795                 800
 Phe Ala Asp Val Val Val Pro Ile Asn Ile Thr Met Lys Asn Thr Ile
                 805                 810                 815    
 Ala Val Gly Val Asp Pro Gln Glu Gly Lys Val Tyr Trp Ser Asp Ser
             820                 825                 830        
 Thr Leu His Arg Ile Ser Arg Ala Asn Leu Asp Gly Ser Gln His Glu
         835                 840                 845            
 Asp Ile Ile Thr Thr Gly Leu Gln Thr Thr Asp Gly Leu Ala Val Asp
     850                 855                 860                
 Ala Ile Gly Arg Lys Val Tyr Trp Thr Asp Thr Gly Thr Asn Arg Ile
 865                 870                 875                 880
 Glu Val Gly Asn Leu Asp Gly Ser Met Arg Lys Val Leu Val Trp Gln
                 885                 890                 895    
 Asn Leu Asp Ser Pro Arg Ala Ile Val Leu Tyr His Glu Met Gly Phe
             900                 905                 910        
 Met Tyr Trp Thr Asp Trp Gly Glu Asn Ala Lys Leu Glu Arg Ser Gly
         915                 920                 925            
 Met Asp Gly Ser Asp Arg Ala Val Leu Ile Asn Asn Asn Leu Gly Trp
     930                 935                 940                
 Pro Asn Gly Leu Thr Val Asp Lys Ala Ser Ser Gln Leu Leu Trp Ala
 945                 950                 955                 960
 Asp Ala His Thr Glu Arg Ile Glu Ala Ala Asp Leu Asn Gly Ala Asn
                 965                 970                 975    
 Arg His Thr Leu Val Ser Pro Val Gln His Pro Tyr Gly Leu Thr Leu
             980                 985                 990        
 Leu Asp Ser Tyr Ile Tyr Trp Thr Asp Trp Gln Thr Arg Ser Ile His
         995                1000                1005            
 Arg Ala Asp Lys Gly Thr Gly Ser Asn Val Ile Leu Val Arg Ser Asn
    1010                1015                1020                
 Leu Pro Gly Leu Met Asp Met Gln Ala Val Asp Arg Ala Gln Pro Leu
1025                1030                1035                1040
 Gly Phe Asn Lys Cys Gly Ser Arg Asn Gly Gly Cys Ser His Leu Cys
                1045                1050                1055    
 Leu Pro Arg Pro Ser Gly Phe Ser Cys Ala Cys Pro Thr Gly Ile Gln
            1060                1065                1070        
 Leu Lys Gly Asp Gly Lys Thr Cys Asp Pro Ser Pro Glu Thr Tyr Leu
        1075                1080                1085            
 Leu Phe Ser Ser Arg Gly Ser Ile Arg Arg Ile Ser Leu Asp Thr Ser
    1090                1095                1100                
 Asp His Thr Asp Val His Val Pro Val Pro Glu Leu Asn Asn Val Ile
1105                1110                1115                1120
 Ser Leu Asp Tyr Asp Ser Val Asp Gly Lys Val Tyr Tyr Thr Asp Val
                1125                1130                1135    
 Phe Leu Asp Val Ile Arg Arg Ala Asp Leu Asn Gly Ser Asn Met Glu
            1140                1145                1150        
 Thr Val Ile Gly Arg Gly Leu Lys Thr Thr Asp Gly Leu Ala Val Asp
        1155                1160                1165            
 Trp Val Ala Arg Asn Leu Tyr Trp Thr Asp Thr Gly Arg Asn Thr Ile
    1170                1175                1180                
 Glu Ala Ser Arg Leu Asp Gly Ser Cys Arg Lys Val Leu Ile Asn Asn
1185                1190                1195                1200
 Ser Leu Asp Glu Pro Arg Ala Ile Ala Val Phe Pro Arg Lys Gly Tyr
                1205                1210                1215    
 Leu Phe Trp Thr Asp Trp Gly His Ile Ala Lys Ile Glu Arg Ala Asn
            1220                1225                1230        
 Leu Asp Gly Ser Glu Arg Lys Val Leu Ile Asn Thr Asp Leu Gly Trp
        1235                1240                1245            
 Pro Asn Gly Leu Thr Leu Asp Tyr Asp Thr Arg Arg Ile Tyr Trp Val
    1250                1255                1260                
 Asp Ala His Leu Asp Arg Ile Glu Ser Ala Asp Leu Asn Gly Lys Leu
1265                1270                1275                1280
 Arg Gln Val Leu Val Gly His Val Ser His Pro Phe Ala Leu Thr Gln
                1285                1290                1295    
 Gln Asp Arg Trp Ile Tyr Trp Thr Asp Trp Gln Thr Lys Ser Ile Gln
            1300                1305                1310        
 Arg Val Asp Lys Tyr Ser Gly Arg Asn Lys Glu Thr Val Leu Ala Asn
        1315                1320                1325            
 Val Glu Gly Leu Met Asp Ile Ile Val Val Ser Pro Gln Arg Gln Thr
    1330                1335                1340                
 Gly Thr Asn Ala Cys Gly Val Asn Asn Gly Gly Cys Thr His Leu Cys
1345                1350                1355                1360
 Phe Ala Arg Ala Ser Asp Phe Val Cys Ala Cys Pro Asp Glu Pro Asp
                1365                1370                1375    
 Ser Arg Pro Cys Ser Leu Val Pro Gly Leu Val Pro Pro Ala Pro Arg
            1380                1385                1390        
 Ala Thr Gly Met Ser Glu Lys Ser Pro Val Leu Pro Asn Thr Pro Pro
        1395                1400                1405            
 Thr Thr Leu Tyr Ser Ser Thr Thr Arg Thr Arg Thr Ser Leu Glu Glu
    1410                1415                1420                
 Val Glu Gly Arg Cys Ser Glu Arg Asp Ala Arg Leu Gly Leu Cys Ala
1425                1430                1435                1440
 Arg Ser Asn Asp Ala Val Pro Ala Ala Pro Gly Glu Gly Leu His Ile
                1445                1450                1455    
 Ser Tyr Ala Ile Gly Gly Leu Leu Ser Ile Leu Leu Ile Leu Val Val
            1460                1465                1470        
 Ile Ala Ala Leu Met Leu Tyr Arg His Lys Lys Ser Lys Phe Thr Asp
        1475                1480                1485            
 Pro Gly Met Gly Asn Leu Thr Tyr Ser Asn Pro Ser Tyr Arg Thr Ser
    1490                1495                1500                
 Thr Gln Glu Val Lys Ile Glu Ala Ile Pro Lys Pro Ala Met Tyr Asn
1505                1510                1515                1520
 Gln Leu Cys Tyr Lys Lys Glu Gly Gly Pro Asp His Asn Tyr Thr Lys
                1525                1530                1535    
 Glu Lys Ile Lys Ile Val Glu Gly Ile Cys Leu Leu Ser Gly Asp Asp
            1540                1545                1550        
 Ala Glu Trp Asp Asp Leu Lys Gln Leu Arg Ser Ser Arg Gly Gly Leu
        1555                1560                1565            
 Leu Arg Asp His Val Cys Met Lys Thr Asp Thr Val Ser Ile Gln Ala
    1570                1575                1580                
 Ser Ser Gly Ser Leu Asp Asp Thr Glu Met Glu Gln Leu Leu Gln Glu
1585                1590                1595                1600
 Glu Gln Ser Glu Cys Ser Ser Val His Thr Ala Ala Thr Pro Glu Arg
                1605                1610                1615    
 Arg Gly Ser Leu Pro Asp Thr Gly Trp Lys His Glu Arg Lys Leu Ser
            1620                1625                1630        
 Ser Glu Ser Gln Val
        1635        



      <210> 336
      <211> 651
      <212> PRT
      <213> Homo sapiens


      <400> 336
 Met Ala Thr Ser Asn Asn Pro Arg Lys Phe Ser Glu Lys Ile Ala Leu
   1               5                  10                  15    
 His Asn Gln Lys Gln Ala Glu Glu Thr Ala Ala Phe Glu Glu Val Met
              20                  25                  30        
 Lys Asp Leu Ser Leu Thr Arg Ala Ala Arg Leu Gln Leu Gln Lys Ser
          35                  40                  45            
 Gln Tyr Leu Gln Leu Gly Pro Ser Arg Gly Gln Tyr Tyr Gly Gly Ser
      50                  55                  60                
 Leu Pro Asn Val Asn Gln Ile Gly Ser Gly Thr Met Asp Leu Pro Phe
  65                  70                  75                  80
 Gln Pro Ser Gly Phe Leu Gly Glu Ala Leu Ala Ala Ala Pro Val Ser
                  85                  90                  95    
 Leu Thr Pro Phe Gln Ser Ser Gly Leu Asp Thr Ser Arg Thr Thr Arg
             100                 105                 110        
 His His Gly Leu Val Asp Arg Val Tyr Arg Glu Arg Gly Arg Leu Gly
         115                 120                 125            
 Ser Pro His Arg Arg Pro Leu Ser Val Asp Lys His Gly Arg Gln Ala
     130                 135                 140                
 Asp Ser Cys Pro Tyr Gly Thr Met Tyr Leu Ser Pro Pro Ala Asp Thr
 145                 150                 155                 160
 Ser Trp Arg Arg Thr Asn Ser Asp Ser Ala Leu His Gln Ser Thr Met
                 165                 170                 175    
 Thr Pro Thr Gln Pro Glu Ser Phe Ser Ser Gly Ser Gln Asp Val His
             180                 185                 190        
 Gln Lys Arg Val Leu Leu Leu Thr Val Pro Gly Met Glu Glu Thr Thr
         195                 200                 205            
 Ser Glu Ala Asp Lys Asn Leu Ser Lys Gln Ala Trp Asp Thr Lys Lys
     210                 215                 220                
 Thr Gly Ser Arg Pro Lys Ser Cys Glu Val Pro Gly Ile Asn Ile Phe
 225                 230                 235                 240
 Pro Ser Ala Asp Gln Glu Asn Thr Thr Ala Leu Ile Pro Ala Thr His
                 245                 250                 255    
 Asn Thr Gly Gly Ser Leu Pro Asp Leu Thr Asn Ile His Phe Pro Ser
             260                 265                 270        
 Pro Leu Pro Thr Pro Leu Asp Pro Glu Glu Pro Thr Phe Pro Ala Leu
         275                 280                 285            
 Ser Ser Ser Ser Ser Thr Gly Asn Leu Ala Ala Asn Leu Thr His Leu
     290                 295                 300                
 Gly Ile Gly Gly Ala Gly Gln Gly Met Ser Thr Pro Gly Ser Ser Pro
 305                 310                 315                 320
 Gln His Arg Pro Ala Gly Val Ser Pro Leu Ser Leu Ser Thr Glu Ala
                 325                 330                 335    
 Arg Arg Gln Gln Ala Ser Pro Thr Leu Ser Pro Leu Ser Pro Ile Thr
             340                 345                 350        
 Gln Ala Val Ala Met Asp Ala Leu Ser Leu Glu Gln Gln Leu Pro Tyr
         355                 360                 365            
 Ala Phe Phe Thr Gln Ala Gly Ser Gln Gln Pro Pro Pro Gln Pro Gln
     370                 375                 380                
 Pro Pro Pro Pro Pro Pro Pro Ala Ser Gln Gln Pro Pro Pro Pro Pro
 385                 390                 395                 400
 Pro Pro Gln Ala Pro Val Arg Leu Pro Pro Gly Gly Pro Leu Leu Pro
                 405                 410                 415    
 Ser Ala Ser Leu Thr Arg Gly Pro Gln Pro Pro Pro Leu Ala Val Thr
             420                 425                 430        
 Val Pro Ser Ser Leu Pro Gln Ser Pro Pro Glu Asn Pro Gly Gln Pro
         435                 440                 445            
 Ser Met Gly Ile Asp Ile Ala Ser Ala Pro Ala Leu Gln Gln Tyr Arg
     450                 455                 460                
 Thr Ser Ala Gly Ser Pro Ala Asn Gln Ser Pro Thr Ser Pro Val Ser
 465                 470                 475                 480
 Asn Gln Gly Phe Ser Pro Gly Ser Ser Pro Gln His Thr Ser Thr Leu
                 485                 490                 495    
 Gly Ser Val Phe Gly Asp Ala Tyr Tyr Glu Gln Gln Met Ala Ala Arg
             500                 505                 510        
 Gln Ala Asn Ala Leu Ser His Gln Leu Glu Gln Phe Asn Met Met Glu
         515                 520                 525            
 Asn Ala Ile Ser Ser Ser Ser Leu Tyr Ser Pro Gly Ser Thr Leu Asn
     530                 535                 540                
 Tyr Ser Gln Ala Ala Met Met Gly Leu Thr Gly Ser His Gly Ser Leu
 545                 550                 555                 560
 Pro Asp Ser Gln Gln Leu Gly Tyr Ala Ser His Ser Gly Ile Pro Asn
                 565                 570                 575    
 Ile Ile Leu Thr Val Thr Gly Glu Ser Pro Pro Ser Leu Ser Lys Glu
             580                 585                 590        
 Leu Thr Ser Ser Leu Ala Gly Val Gly Asp Val Ser Phe Asp Ser Asp
         595                 600                 605            
 Ser Gln Phe Pro Leu Asp Glu Leu Lys Ile Asp Pro Leu Thr Leu Asp
     610                 615                 620                
 Gly Leu His Met Leu Asn Asp Pro Asp Met Val Leu Ala Asp Pro Ala
 625                 630                 635                 640
 Thr Glu Asp Thr Phe Arg Met Asp Arg Leu
                 645                 650



      <210> 337
      <211> 138
      <212> PRT
      <213> Homo sapiens


      <400> 337
 Met Arg Asn Gly Ile Ser Pro Ile Ile Ile Asp Asn Thr Asn Leu His
   1               5                  10                  15    
 Ala Trp Glu Met Lys Pro Tyr Ala Val Met Ala Leu Glu Asn Asn Tyr
              20                  25                  30        
 Glu Val Ile Phe Arg Glu Pro Asp Thr Arg Trp Lys Phe Asn Val Gln
          35                  40                  45            
 Glu Leu Ala Arg Arg Asn Ile His Gly Val Ser Arg Glu Lys Ile His
      50                  55                  60                
 Arg Met Lys Glu Arg Tyr Glu His Asp Val Thr Phe His Ser Val Leu
  65                  70                  75                  80
 His Ala Glu Lys Pro Ser Arg Met Asn Arg Asn Gln Asp Arg Asn Asn
                  85                  90                  95    
 Ala Leu Pro Ser Asn Asn Ala Arg Tyr Trp Asn Ser Tyr Thr Glu Phe
             100                 105                 110        
 Pro Asn Arg Arg Ala His Gly Gly Phe Thr Asn Glu Ser Ser Tyr His
         115                 120                 125            
 Arg Arg Gly Gly Cys His His Gly Tyr
     130                 135        



      <210> 338
      <211> 1319
      <212> PRT
      <213> Homo sapiens


      <400> 338
 Met Ser Gly Gly Ala Ser Ala Thr Gly Pro Arg Arg Gly Pro Pro Gly
   1               5                  10                  15    
 Leu Glu Asp Thr Thr Ser Lys Lys Lys Gln Lys Asp Arg Ala Asn Gln
              20                  25                  30        
 Glu Ser Lys Asp Gly Asp Pro Arg Lys Glu Thr Gly Ser Arg Tyr Val
          35                  40                  45            
 Ala Gln Ala Gly Leu Glu Pro Leu Ala Ser Gly Asp Pro Ser Ala Ser
      50                  55                  60                
 Ala Ser His Ala Ala Gly Ile Thr Gly Ser Arg His Arg Thr Arg Leu
  65                  70                  75                  80
 Phe Phe Pro Ser Ser Ser Gly Ser Ala Ser Thr Pro Gln Glu Glu Gln
                  85                  90                  95    
 Thr Lys Glu Gly Ala Cys Glu Asp Pro His Asp Leu Leu Ala Thr Pro
             100                 105                 110        
 Thr Pro Glu Leu Leu Leu Asp Trp Arg Gln Ser Ala Glu Glu Val Ile
         115                 120                 125            
 Val Lys Leu Arg Val Gly Val Gly Pro Leu Gln Leu Glu Asp Val Asp
     130                 135                 140                
 Ala Ala Phe Thr Asp Thr Asp Cys Val Val Arg Phe Ala Gly Gly Gln
 145                 150                 155                 160
 Gln Trp Gly Gly Val Phe Tyr Ala Glu Ile Lys Ser Ser Cys Ala Lys
                 165                 170                 175    
 Val Gln Thr Arg Lys Gly Ser Leu Leu His Leu Thr Leu Pro Lys Lys
             180                 185                 190        
 Val Pro Met Leu Thr Trp Pro Ser Leu Leu Val Glu Ala Asp Glu Gln
         195                 200                 205            
 Leu Cys Ile Pro Pro Leu Asn Ser Gln Thr Cys Leu Leu Gly Ser Glu
     210                 215                 220                
 Glu Asn Leu Ala Pro Leu Ala Gly Glu Lys Ala Val Pro Pro Gly Asn
 225                 230                 235                 240
 Asp Pro Val Ser Pro Ala Met Val Arg Ser Arg Asn Pro Gly Lys Asp
                 245                 250                 255    
 Asp Cys Ala Lys Glu Glu Met Ala Val Ala Ala Asp Ala Ala Thr Leu
             260                 265                 270        
 Val Asp Glu Pro Glu Ser Met Val Asn Leu Ala Phe Val Lys Asn Asp
         275                 280                 285            
 Ser Tyr Glu Lys Gly Pro Asp Ser Val Val Val His Val Tyr Val Lys
     290                 295                 300                
 Glu Ile Cys Arg Asp Thr Ser Arg Val Leu Phe Arg Glu Gln Asp Phe
 305                 310                 315                 320
 Thr Leu Ile Phe Gln Thr Arg Asp Gly Asn Phe Leu Arg Leu His Pro
                 325                 330                 335    
 Gly Cys Gly Pro His Thr Thr Phe Arg Trp Gln Val Lys Leu Arg Asn
             340                 345                 350        
 Leu Ile Glu Pro Glu Gln Cys Thr Phe Cys Phe Thr Ala Ser Arg Ile
         355                 360                 365            
 Asp Ile Cys Leu Arg Lys Arg Gln Ser Gln Arg Trp Gly Gly Leu Glu
     370                 375                 380                
 Ala Pro Ala Ala Arg Val Gly Gly Ala Lys Val Ala Val Pro Thr Gly
 385                 390                 395                 400
 Pro Thr Pro Leu Asp Ser Thr Pro Pro Gly Gly Ala Pro His Pro Leu
                 405                 410                 415    
 Thr Gly Gln Glu Glu Ala Arg Ala Val Glu Lys Asp Lys Ser Lys Ala
             420                 425                 430        
 Arg Ser Glu Asp Thr Gly Leu Asp Ser Val Ala Thr Arg Thr Pro Met
         435                 440                 445            
 Glu His Val Thr Pro Lys Pro Glu Thr His Leu Ala Ser Pro Lys Pro
     450                 455                 460                
 Thr Cys Met Val Pro Pro Met Pro His Ser Pro Val Ser Gly Asp Ser
 465                 470                 475                 480
 Val Glu Glu Glu Glu Glu Glu Glu Lys Lys Val Cys Leu Pro Gly Phe
                 485                 490                 495    
 Thr Gly Leu Val Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Val Ile
             500                 505                 510        
 Gln Ser Leu Ser Asn Thr Arg Glu Leu Arg Asp Phe Phe His Asp Arg
         515                 520                 525            
 Ser Phe Glu Ala Glu Ile Asn Tyr Asn Asn Pro Leu Gly Thr Gly Gly
     530                 535                 540                
 Arg Leu Ala Ile Gly Phe Ala Val Leu Leu Arg Ala Leu Trp Lys Gly
 545                 550                 555                 560
 Thr His His Ala Phe Gln Pro Ser Lys Leu Lys Ala Ile Val Ala Ser
                 565                 570                 575    
 Lys Ala Ser Gln Phe Thr Gly Tyr Ala Gln His Asp Ala Gln Glu Phe
             580                 585                 590        
 Met Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Ile Gln
         595                 600                 605            
 Asn Lys Pro Tyr Thr Glu Thr Val Asp Ser Asp Gly Arg Pro Asp Glu
     610                 615                 620                
 Val Val Ala Glu Glu Ala Trp Gln Arg His Lys Met Arg Asn Asp Ser
 625                 630                 635                 640
 Phe Ile Val Asp Leu Phe Gln Gly Gln Tyr Lys Ser Lys Leu Val Cys
                 645                 650                 655    
 Pro Val Cys Ala Lys Val Ser Ile Thr Phe Asp Pro Phe Leu Tyr Leu
             660                 665                 670        
 Pro Val Pro Leu Pro Gln Lys Gln Lys Val Leu Pro Val Phe Tyr Phe
         675                 680                 685            
 Ala Arg Glu Pro His Ser Lys Pro Ile Lys Phe Leu Val Ser Val Ser
     690                 695                 700                
 Lys Glu Asn Ser Thr Ala Ser Glu Val Leu Asp Ser Leu Ser Gln Ser
 705                 710                 715                 720
 Val His Val Lys Pro Glu Asn Leu Arg Leu Ala Glu Val Ile Lys Asn
                 725                 730                 735    
 Arg Phe His Arg Val Phe Leu Pro Ser His Ser Leu Asp Thr Val Ser
             740                 745                 750        
 Pro Ser Asp Thr Leu Leu Cys Phe Glu Leu Leu Ser Ser Glu Leu Ala
         755                 760                 765            
 Lys Glu Arg Val Val Val Leu Glu Val Gln Gln Arg Pro Gln Val Pro
     770                 775                 780                
 Ser Val Pro Ile Ser Lys Cys Ala Ala Cys Gln Arg Lys Gln Gln Ser
 785                 790                 795                 800
 Glu Asp Glu Lys Leu Lys Arg Cys Thr Arg Cys Tyr Arg Val Gly Tyr
                 805                 810                 815    
 Cys Asn Gln Leu Cys Gln Lys Thr His Trp Pro Asp His Lys Gly Leu
             820                 825                 830        
 Cys Arg Pro Glu Asn Ile Gly Tyr Pro Phe Leu Val Ser Val Pro Ala
         835                 840                 845            
 Ser Arg Leu Thr Tyr Ala Arg Leu Ala Gln Leu Leu Glu Gly Tyr Ala
     850                 855                 860                
 Arg Tyr Ser Val Ser Val Phe Gln Pro Pro Phe Gln Pro Gly Arg Met
 865                 870                 875                 880
 Ala Leu Glu Ser Gln Ser Pro Gly Cys Thr Thr Leu Leu Ser Thr Gly
                 885                 890                 895    
 Ser Leu Glu Ala Gly Asp Ser Glu Arg Asp Pro Ile Gln Pro Pro Glu
             900                 905                 910        
 Leu Gln Leu Val Thr Pro Met Ala Glu Gly Asp Thr Gly Leu Pro Arg
         915                 920                 925            
 Val Trp Ala Ala Pro Asp Arg Gly Pro Val Pro Ser Thr Ser Gly Ile
     930                 935                 940                
 Ser Ser Glu Met Leu Ala Ser Gly Pro Ile Glu Val Gly Ser Leu Pro
 945                 950                 955                 960
 Ala Gly Glu Arg Val Ser Arg Pro Glu Ala Ala Val Pro Gly Tyr Gln
                 965                 970                 975    
 His Pro Ser Glu Ala Met Asn Ala His Thr Pro Gln Phe Phe Ile Tyr
             980                 985                 990        
 Lys Ile Asp Ser Ser Asn Arg Glu Gln Arg Leu Glu Asp Lys Gly Asp
         995                1000                1005            
 Thr Pro Leu Glu Leu Gly Asp Asp Cys Ser Leu Ala Leu Val Trp Arg
    1010                1015                1020                
 Asn Asn Glu Arg Leu Gln Glu Phe Val Leu Val Ala Ser Lys Glu Leu
1025                1030                1035                1040
 Glu Cys Ala Glu Asp Pro Gly Ser Ala Gly Glu Ala Ala Arg Ala Gly
                1045                1050                1055    
 His Phe Thr Leu Asp Gln Cys Leu Asn Leu Phe Thr Arg Pro Glu Val
            1060                1065                1070        
 Leu Ala Pro Glu Glu Ala Trp Tyr Cys Pro Gln Cys Lys Gln His Arg
        1075                1080                1085            
 Glu Ala Ser Lys Gln Leu Leu Leu Trp Arg Leu Pro Asn Val Leu Ile
    1090                1095                1100                
 Val Gln Leu Lys Arg Phe Ser Phe Arg Ser Phe Ile Trp Arg Asp Lys
1105                1110                1115                1120
 Ile Asn Asp Leu Val Glu Phe Pro Val Arg Asn Leu Asp Leu Ser Lys
                1125                1130                1135    
 Phe Cys Ile Gly Gln Lys Glu Glu Gln Leu Pro Ser Tyr Asp Leu Tyr
            1140                1145                1150        
 Ala Val Ile Asn His Tyr Gly Gly Met Ile Gly Gly His Tyr Thr Ala
        1155                1160                1165            
 Cys Ala Arg Leu Pro Asn Asp Arg Ser Ser Gln Arg Ser Asp Val Gly
    1170                1175                1180                
 Trp Arg Leu Phe Asp Asp Ser Thr Val Thr Thr Val Asp Glu Ser Gln
1185                1190                1195                1200
 Val Val Thr Arg Tyr Ala Tyr Val Leu Phe Tyr Arg Arg Arg Asn Ser
                1205                1210                1215    
 Pro Val Glu Arg Pro Pro Arg Ala Gly His Ser Glu His His Pro Asp
            1220                1225                1230        
 Leu Gly Pro Ala Ala Glu Ala Ala Ala Ser Gln Ala Ser Arg Ile Trp
        1235                1240                1245            
 Gln Glu Leu Glu Ala Glu Glu Glu Pro Val Pro Glu Gly Ser Gly Pro
    1250                1255                1260                
 Leu Gly Pro Trp Gly Pro Gln Asp Trp Val Gly Pro Leu Pro Arg Gly
1265                1270                1275                1280
 Pro Thr Thr Pro Asp Glu Gly Cys Leu Arg Tyr Phe Val Leu Gly Thr
                1285                1290                1295    
 Val Ala Ala Leu Val Ala Leu Val Leu Asn Val Phe Tyr Pro Leu Val
            1300                1305                1310        
 Ser Gln Ser Arg Trp Arg
        1315            



      <210> 339
      <211> 681
      <212> PRT
      <213> Homo sapiens


      <400> 339
 Met Glu Glu Ala Cys Gln Val Gln Thr Thr Lys Arg Gly Asp Pro His
   1               5                  10                  15    
 Glu Leu Arg Asn Ile Phe Leu Gln Tyr Ala Ser Thr Glu Val Asp Gly
              20                  25                  30        
 Glu Arg Tyr Met Thr Pro Glu Asp Phe Val Gln Arg Tyr Leu Gly Leu
          35                  40                  45            
 Tyr Asn Asp Pro Asn Ser Asn Pro Lys Ile Val Gln Leu Leu Ala Gly
      50                  55                  60                
 Val Ala Asp Gln Thr Lys Asp Gly Leu Ile Ser Tyr Gln Glu Phe Leu
  65                  70                  75                  80
 Ala Phe Glu Ser Val Leu Cys Ala Pro Asp Ser Met Phe Ile Val Ala
                  85                  90                  95    
 Phe Gln Leu Phe Asp Lys Ser Gly Asn Gly Glu Val Thr Phe Glu Asn
             100                 105                 110        
 Val Lys Glu Ile Phe Gly Gln Thr Ile Ile His His His Ile Pro Phe
         115                 120                 125            
 Asn Trp Asp Cys Glu Phe Ile Arg Leu His Phe Gly His Asn Arg Lys
     130                 135                 140                
 Lys His Leu Asn Tyr Thr Glu Phe Thr Gln Phe Leu Gln Glu Leu Gln
 145                 150                 155                 160
 Leu Glu His Ala Arg Gln Ala Phe Ala Leu Lys Asp Lys Ser Lys Ser
                 165                 170                 175    
 Gly Met Ile Ser Gly Leu Asp Phe Ser Asp Ile Met Val Thr Ile Arg
             180                 185                 190        
 Ser His Met Leu Thr Pro Phe Val Glu Glu Asn Leu Val Ser Ala Ala
         195                 200                 205            
 Gly Gly Ser Ile Ser His Gln Val Ser Phe Ser Tyr Phe Asn Ala Phe
     210                 215                 220                
 Asn Ser Leu Leu Asn Asn Met Glu Leu Val Arg Lys Ile Tyr Ser Thr
 225                 230                 235                 240
 Leu Ala Gly Thr Arg Lys Asp Val Glu Val Thr Lys Glu Glu Phe Ala
                 245                 250                 255    
 Gln Ser Ala Ile Arg Tyr Gly Gln Val Thr Pro Leu Glu Ile Asp Ile
             260                 265                 270        
 Leu Tyr Gln Leu Ala Asp Leu Tyr Asn Ala Ser Gly Arg Leu Thr Leu
         275                 280                 285            
 Ala Asp Ile Glu Arg Ile Ala Pro Leu Ala Glu Gly Ala Leu Pro Tyr
     290                 295                 300                
 Asn Leu Ala Glu Leu Gln Arg Gln Gln Ser Pro Gly Leu Gly Arg Pro
 305                 310                 315                 320
 Ile Trp Leu Gln Ile Ala Glu Ser Ala Tyr Arg Phe Thr Leu Gly Ser
                 325                 330                 335    
 Val Ala Gly Ala Val Gly Ala Thr Ala Val Tyr Pro Ile Asp Leu Val
             340                 345                 350        
 Lys Thr Arg Met Gln Asn Gln Arg Gly Ser Gly Ser Val Val Gly Glu
         355                 360                 365            
 Leu Met Tyr Lys Asn Ser Phe Asp Cys Phe Lys Lys Val Leu Arg Tyr
     370                 375                 380                
 Glu Gly Phe Phe Gly Leu Tyr Arg Gly Leu Ile Pro Gln Leu Ile Gly
 385                 390                 395                 400
 Val Ala Pro Glu Lys Ala Ile Lys Leu Thr Val Asn Asp Phe Val Arg
                 405                 410                 415    
 Asp Lys Phe Thr Arg Arg Asp Gly Ser Val Pro Leu Pro Ala Glu Val
             420                 425                 430        
 Leu Ala Gly Gly Cys Ala Gly Gly Ser Gln Val Ile Phe Thr Asn Pro
         435                 440                 445            
 Leu Glu Ile Val Lys Ile Arg Leu Gln Val Ala Gly Glu Ile Thr Thr
     450                 455                 460                
 Gly Pro Arg Val Ser Ala Leu Asn Val Leu Arg Asp Leu Gly Ile Phe
 465                 470                 475                 480
 Gly Leu Tyr Lys Gly Ala Lys Ala Cys Phe Leu Arg Asp Ile Pro Phe
                 485                 490                 495    
 Ser Ala Ile Tyr Phe Pro Val Tyr Ala His Cys Lys Leu Leu Leu Ala
             500                 505                 510        
 Asp Glu Asn Gly His Val Gly Gly Leu Asn Leu Leu Ala Ala Gly Ala
         515                 520                 525            
 Met Ala Gly Val Pro Ala Ala Ser Leu Val Thr Pro Ala Asp Val Ile
     530                 535                 540                
 Lys Thr Arg Leu Gln Val Ala Ala Arg Ala Gly Gln Thr Thr Tyr Ser
 545                 550                 555                 560
 Gly Val Ile Asp Cys Phe Arg Lys Ile Leu Arg Glu Glu Gly Pro Ser
                 565                 570                 575    
 Ala Phe Trp Lys Gly Thr Ala Ala Arg Val Phe Arg Ser Ser Pro Gln
             580                 585                 590        
 Phe Gly Val Thr Leu Val Thr Tyr Glu Leu Leu Gln Arg Trp Phe Tyr
         595                 600                 605            
 Ile Asp Phe Gly Gly Leu Lys Pro Ala Gly Ser Glu Pro Thr Pro Lys
     610                 615                 620                
 Ser Arg Ile Ala Asp Leu Pro Pro Ala Asn Pro Asp His Ile Gly Gly
 625                 630                 635                 640
 Tyr Arg Leu Ala Thr Ala Thr Phe Ala Gly Ile Glu Asn Lys Phe Gly
                 645                 650                 655    
 Leu Tyr Leu Pro Lys Phe Lys Ser Pro Ser Val Ala Val Val Gln Pro
             660                 665                 670        
 Lys Ala Ala Val Ala Ala Thr Gln
         675                 680



      <210> 340
      <211> 782
      <212> PRT
      <213> Homo sapiens


      <400> 340
 Met Leu Ala Phe Leu Ser Gly Met Pro Val Thr Arg Asn Thr Lys Tyr
   1               5                  10                  15    
 Leu Asp Leu Lys Asn Ser Gln Glu Met Leu Arg Tyr Lys Glu Val Cys
              20                  25                  30        
 Tyr Tyr Met Leu Phe Ala Leu Ala Ala Tyr Gly Trp Pro Met Tyr Leu
          35                  40                  45            
 Met Arg Lys Pro Ala Cys Gly Leu Cys Gln Leu Ala Arg Ser Cys Ser
      50                  55                  60                
 Cys Cys Leu Cys Pro Ala Arg Pro Arg Phe Ala Pro Gly Val Thr Ile
  65                  70                  75                  80
 Glu Glu Asp Asn Cys Cys Gly Cys Asn Ala Ile Ala Ile Arg Arg His
                  85                  90                  95    
 Phe Leu Asp Glu Asn Met Thr Ala Val Asp Ile Val Tyr Thr Ser Cys
             100                 105                 110        
 His Asp Ala Val Tyr Glu Thr Pro Phe Tyr Val Ala Val Asp His Asp
         115                 120                 125            
 Lys Lys Lys Val Val Ile Ser Ile Arg Gly Thr Leu Ser Pro Lys Asp
     130                 135                 140                
 Ala Leu Thr Asp Leu Thr Gly Asp Ala Glu Arg Leu Pro Val Glu Gly
 145                 150                 155                 160
 His His Gly Thr Trp Leu Gly His Lys Gly Met Val Leu Ser Ala Glu
                 165                 170                 175    
 Tyr Ile Lys Lys Lys Leu Glu Gln Glu Met Val Leu Ser Gln Ala Phe
             180                 185                 190        
 Gly Arg Asp Leu Gly Arg Gly Thr Lys His Tyr Gly Leu Ile Val Val
         195                 200                 205            
 Gly His Ser Leu Gly Ala Gly Thr Ala Ala Ile Leu Ser Phe Leu Leu
     210                 215                 220                
 Arg Pro Gln Tyr Pro Thr Leu Lys Cys Phe Ala Tyr Ser Pro Pro Gly
 225                 230                 235                 240
 Gly Leu Leu Ser Glu Asp Ala Met Glu Tyr Ser Lys Glu Phe Val Thr
                 245                 250                 255    
 Ala Val Val Leu Gly Lys Asp Leu Val Pro Arg Ile Gly Leu Ser Gln
             260                 265                 270        
 Leu Glu Gly Phe Arg Arg Gln Leu Leu Asp Val Leu Gln Arg Ser Thr
         275                 280                 285            
 Lys Pro Lys Trp Arg Ile Ile Val Gly Ala Thr Lys Cys Ile Pro Lys
     290                 295                 300                
 Ser Glu Leu Pro Glu Glu Val Glu Val Thr Thr Leu Ala Ser Thr Arg
 305                 310                 315                 320
 Leu Trp Thr His Pro Ser Asp Leu Thr Ile Ala Leu Ser Ala Ser Thr
                 325                 330                 335    
 Pro Leu Tyr Pro Pro Gly Arg Ile Ile His Val Val His Asn His Pro
             340                 345                 350        
 Ala Glu Gln Cys Cys Cys Cys Glu Gln Glu Glu Pro Thr Tyr Phe Ala
         355                 360                 365            
 Ile Trp Gly Asp Asn Lys Ala Phe Asn Glu Val Ile Ile Ser Pro Ala
     370                 375                 380                
 Met Leu His Glu His Leu Pro Tyr Val Val Met Glu Gly Leu Asn Lys
 385                 390                 395                 400
 Val Leu Glu Asn Tyr Asn Lys Gly Lys Thr Ala Leu Leu Ser Ala Ala
                 405                 410                 415    
 Lys Val Met Val Ser Pro Thr Glu Val Asp Leu Thr Pro Glu Leu Ile
             420                 425                 430        
 Phe Gln Gln Gln Pro Leu Pro Thr Gly Pro Pro Met Pro Thr Gly Leu
         435                 440                 445            
 Ala Leu Glu Leu Pro Thr Ala Asp His Arg Asn Ser Ser Val Arg Ser
     450                 455                 460                
 Lys Ser Gln Ser Glu Met Ser Leu Glu Gly Phe Ser Glu Gly Arg Leu
 465                 470                 475                 480
 Leu Ser Pro Val Val Ala Ala Ala Ala Arg Gln Asp Pro Val Glu Leu
                 485                 490                 495    
 Leu Leu Leu Ser Thr Gln Glu Arg Leu Ala Ala Glu Leu Gln Ala Arg
             500                 505                 510        
 Arg Ala Pro Leu Ala Thr Met Glu Ser Leu Ser Asp Thr Glu Ser Leu
         515                 520                 525            
 Tyr Ser Phe Asp Ser Arg Arg Ser Ser Gly Phe Arg Ser Ile Arg Gly
     530                 535                 540                
 Ser Pro Ser Leu His Ala Val Leu Glu Arg Asp Glu Gly His Leu Phe
 545                 550                 555                 560
 Tyr Ile Asp Pro Ala Ile Pro Glu Glu Asn Pro Ser Leu Ser Ser Arg
                 565                 570                 575    
 Thr Glu Leu Leu Ala Ala Asp Ser Leu Ser Lys His Ser Gln Asp Thr
             580                 585                 590        
 Gln Pro Leu Glu Ala Ala Leu Gly Ser Gly Gly Val Thr Pro Glu Arg
         595                 600                 605            
 Pro Pro Ser Ala Ala Ala Asn Asp Glu Glu Glu Glu Val Gly Gly Gly
     610                 615                 620                
 Gly Gly Gly Pro Ala Ser Arg Gly Glu Leu Ala Leu His Asn Gly Arg
 625                 630                 635                 640
 Leu Gly Asp Ser Pro Ser Pro Gln Val Leu Glu Phe Ala Glu Phe Ile
                 645                 650                 655    
 Asp Ser Leu Phe Asn Leu Asp Ser Lys Ser Ser Ser Phe Gln Asp Leu
             660                 665                 670        
 Tyr Cys Met Val Val Pro Glu Ser Pro Thr Ser Asp Tyr Ala Glu Gly
         675                 680                 685            
 Pro Lys Ser Pro Ser Gln Gln Glu Ile Leu Leu Arg Ala Gln Phe Glu
     690                 695                 700                
 Pro Asn Leu Val Pro Lys Pro Pro Arg Leu Phe Ala Gly Ser Ala Asp
 705                 710                 715                 720
 Pro Ser Ser Gly Ile Ser Leu Ser Pro Ser Phe Pro Leu Ser Ser Ser
                 725                 730                 735    
 Gly Glu Leu Met Asp Leu Thr Pro Thr Gly Leu Ser Ser Gln Glu Cys
             740                 745                 750        
 Leu Ala Ala Asp Lys Ile Arg Thr Ser Thr Pro Thr Gly His Gly Ala
         755                 760                 765            
 Ser Pro Ala Lys Gln Asp Glu Leu Val Ile Ser Ala Arg
     770                 775                 780    



      <210> 341
      <211> 141
      <212> PRT
      <213> Homo sapiens


      <400> 341
 Met Ser Leu Glu Pro Gln Asn Gly Thr Tyr Ala Gly Pro Ala Pro Ala
   1               5                  10                  15    
 Phe Gln Pro Phe Phe Phe Thr Gly Ala Phe Pro Phe Asn Met Gln Glu
              20                  25                  30        
 Leu Val Leu Lys Val Arg Ile Gln Asn Pro Ser Leu Arg Glu Asn Asp
          35                  40                  45            
 Phe Ile Glu Ile Glu Leu Asp Arg Gln Glu Leu Thr Tyr Gln Glu Leu
      50                  55                  60                
 Leu Lys Val Cys Cys Cys Glu Leu Gly Val Asn Pro Asp Gln Val Glu
  65                  70                  75                  80
 Lys Ile Arg Lys Leu Pro Asn Thr Leu Leu Arg Lys Asp Lys Asp Val
                  85                  90                  95    
 Ala Arg Leu Gln Asp Phe Gln Glu Leu Glu Leu Val Leu Met Ile Ser
             100                 105                 110        
 Glu Asn Asn Phe Leu Phe Arg Asn Ala Ala Ser Thr Leu Thr Glu Arg
         115                 120                 125            
 Pro Cys Tyr Asn Arg Arg Ala Ser Lys Leu Thr Tyr
     130                 135                 140



      <210> 342
      <211> 319
      <212> PRT
      <213> Homo sapiens


      <400> 342
 Met Ser Pro Phe Leu Pro Ala Thr Tyr Arg Arg Arg Leu Gly Leu Asp
   1               5                  10                  15    
 Trp Cys Leu Ile Thr Met Gly Lys Ser Ser Arg Lys Pro Pro Thr Pro
              20                  25                  30        
 Thr Pro Glu Gly Pro Thr Val Ser Val Lys Gln Leu Phe Ser Thr Leu
          35                  40                  45            
 Pro Val Arg His Lys Glu Phe Gln Arg Asn Ile Lys Lys Lys Arg Ala
      50                  55                  60                
 Cys Phe Pro Phe Ala Phe Cys Arg Asp Cys Gln Phe Leu Glu Gly Ser
  65                  70                  75                  80
 Pro Ala Met Leu Pro Val Gln Pro Ala Lys Leu Thr Glu Pro Ala Lys
                  85                  90                  95    
 Ala Ile Lys Pro Ile Asp Arg Lys Ser Val His Gln Ile Cys Ser Gly
             100                 105                 110        
 Pro Val Val Leu Ser Leu Ser Thr Ala Val Lys Lys Ile Val Gly Asn
         115                 120                 125            
 Ser Leu Asp Ala Gly Ala Thr Asn Ile Asp Leu Lys Leu Lys Asp Tyr
     130                 135                 140                
 Gly Met Asp Leu Ile Glu Val Ser Gly Asn Gly Cys Gly Val Glu Glu
 145                 150                 155                 160
 Glu Asn Phe Glu Gly Leu Ser Leu Ser Ala Leu Lys His His Thr Ser
                 165                 170                 175    
 Lys Ile Arg Glu Phe Ala Asp Leu Thr Arg Val Glu Thr Phe Gly Phe
             180                 185                 190        
 Gln Gly Lys Ala Leu Ser Ser Leu Cys Ala Leu Ser Asp Val Thr Ile
         195                 200                 205            
 Ser Thr Cys His Val Ser Ala Lys Val Gly Thr Arg Leu Val Phe Asp
     210                 215                 220                
 His Asp Gly Lys Ile Ile Lys Lys Thr Pro Tyr Pro His Pro Arg Gly
 225                 230                 235                 240
 Thr Thr Val Ser Val Lys Gln Leu Phe Ser Thr Leu Pro Val Arg His
                 245                 250                 255    
 Lys Glu Phe Gln Arg Asn Ile Lys Lys Lys Arg Ala Cys Phe Pro Phe
             260                 265                 270        
 Ala Phe Cys Arg Asp Cys Gln Phe Leu Glu Gly Ser Pro Ala Met Leu
         275                 280                 285            
 Pro Val Gln Pro Ala Lys Leu Thr Val Thr Gly Glu Leu Arg Ala Cys
     290                 295                 300                
 Arg Ser Trp Lys Thr Arg Glu Gly Ile Thr Glu Ala Val Gly
 305                 310                 315            



      <210> 343
      <211> 1054
      <212> PRT
      <213> Homo sapiens


      <400> 343
 Met Ala Phe Leu Lys Leu Arg Asp Gln Pro Ser Leu Val Gln Ala Ile
   1               5                  10                  15    
 Phe Asn Gly Asp Pro Asp Glu Val Arg Ala Leu Ile Phe Lys Lys Glu
              20                  25                  30        
 Asp Val Asn Phe Gln Asp Asn Glu Lys Arg Thr Pro Leu His Ala Ala
          35                  40                  45            
 Ala Tyr Leu Gly Asp Ala Glu Ile Ile Glu Leu Leu Ile Leu Ser Gly
      50                  55                  60                
 Ala Arg Val Asn Ala Lys Asp Ser Lys Trp Leu Thr Pro Leu His Arg
  65                  70                  75                  80
 Ala Val Ala Ser Cys Ser Glu Glu Ala Val Gln Val Leu Leu Lys His
                  85                  90                  95    
 Ser Ala Asp Val Asn Ala Arg Asp Lys Asn Trp Gln Thr Pro Leu His
             100                 105                 110        
 Ile Ala Ala Ala Asn Lys Ala Val Lys Cys Ala Glu Ala Leu Val Pro
         115                 120                 125            
 Leu Leu Ser Asn Val Asn Val Ser Asp Arg Ala Gly Arg Thr Ala Leu
     130                 135                 140                
 His His Ala Ala Phe Ser Gly His Gly Glu Met Val Lys Leu Leu Leu
 145                 150                 155                 160
 Ser Arg Gly Ala Asn Ile Asn Ala Phe Asp Lys Lys Asp Arg Arg Ala
                 165                 170                 175    
 Ile His Trp Ala Ala Tyr Met Gly His Ile Glu Val Val Lys Leu Leu
             180                 185                 190        
 Val Ser His Gly Ala Glu Val Thr Cys Lys Asp Lys Lys Ser Tyr Thr
         195                 200                 205            
 Pro Leu His Ala Ala Ala Ser Ser Gly Met Ile Ser Val Val Lys Tyr
     210                 215                 220                
 Leu Leu Asp Leu Gly Val Asp Met Asn Glu Pro Asn Ala Tyr Gly Asn
 225                 230                 235                 240
 Thr Pro Leu His Val Ala Cys Tyr Asn Gly Gln Asp Val Val Val Asn
                 245                 250                 255    
 Glu Leu Ile Asp Cys Gly Ala Ile Val Asn Gln Lys Asn Glu Lys Gly
             260                 265                 270        
 Phe Thr Pro Leu His Phe Ala Ala Ala Ser Thr His Gly Ala Leu Cys
         275                 280                 285            
 Leu Glu Leu Leu Val Gly Asn Gly Ala Asp Val Asn Met Lys Ser Lys
     290                 295                 300                
 Asp Gly Lys Thr Pro Leu His Met Thr Ala Leu His Gly Arg Phe Ser
 305                 310                 315                 320
 Arg Ser Gln Thr Ile Ile Gln Ser Gly Ala Val Ile Asp Cys Glu Asp
                 325                 330                 335    
 Lys Asn Gly Asn Thr Pro Leu His Ile Ala Ala Arg Tyr Gly His Glu
             340                 345                 350        
 Leu Leu Ile Asn Thr Leu Ile Thr Ser Gly Ala Asp Thr Ala Lys Arg
         355                 360                 365            
 Gly Ile His Gly Met Phe Pro Leu His Leu Ala Ala Leu Ser Gly Phe
     370                 375                 380                
 Ser Asp Cys Cys Arg Lys Leu Leu Ser Ser Gly Phe Asp Ile Asp Thr
 385                 390                 395                 400
 Pro Asp Asp Phe Gly Arg Thr Cys Leu His Ala Ala Ala Ala Gly Gly
                 405                 410                 415    
 Asn Leu Glu Cys Leu Asn Leu Leu Leu Asn Thr Gly Ala Asp Phe Asn
             420                 425                 430        
 Lys Lys Asp Lys Phe Gly Arg Ser Pro Leu His Tyr Ala Ala Ala Asn
         435                 440                 445            
 Cys Asn Tyr Gln Cys Leu Phe Ala Leu Val Gly Ser Gly Ala Ser Val
     450                 455                 460                
 Asn Asp Leu Asp Glu Arg Gly Cys Thr Pro Leu His Tyr Ala Ala Thr
 465                 470                 475                 480
 Ser Asp Thr Asp Gly Lys Cys Leu Glu Tyr Leu Leu Arg Asn Asp Ala
                 485                 490                 495    
 Asn Pro Gly Ile Arg Asp Lys Gln Gly Tyr Asn Ala Val His Tyr Ser
             500                 505                 510        
 Ala Ala Tyr Gly His Arg Leu Cys Leu Gln Leu Ile Ala Ser Glu Thr
         515                 520                 525            
 Pro Leu Asp Val Leu Met Glu Thr Ser Gly Thr Asp Met Leu Ser Asp
     530                 535                 540                
 Ser Asp Asn Arg Ala Thr Ile Ser Pro Leu His Leu Ala Ala Tyr His
 545                 550                 555                 560
 Gly His His Gln Ala Leu Glu Val Leu Val Gln Ser Leu Leu Asp Leu
                 565                 570                 575    
 Asp Val Arg Asn Ser Ser Gly Arg Thr Pro Leu Asp Leu Ala Ala Phe
             580                 585                 590        
 Lys Gly His Val Glu Cys Val Asp Val Leu Ile Asn Gln Gly Ala Ser
         595                 600                 605            
 Ile Leu Val Lys Asp Tyr Ile Leu Lys Arg Thr Pro Ile His Ala Ala
     610                 615                 620                
 Ala Thr Asn Gly His Ser Glu Cys Leu Arg Leu Leu Ile Gly Asn Ala
 625                 630                 635                 640
 Glu Pro Gln Asn Ala Val Asp Ile Gln Asp Gly Asn Gly Gln Thr Pro
                 645                 650                 655    
 Leu Met Leu Ser Val Leu Asn Gly His Thr Asp Cys Val Tyr Ser Leu
             660                 665                 670        
 Leu Asn Lys Gly Ala Asn Val Asp Ala Lys Asp Lys Trp Gly Arg Thr
         675                 680                 685            
 Ala Leu His Arg Gly Ala Val Thr Gly His Glu Glu Cys Val Asp Ala
     690                 695                 700                
 Leu Leu Gln His Gly Ala Lys Cys Leu Leu Arg Asp Ser Arg Gly Arg
 705                 710                 715                 720
 Thr Pro Ile His Leu Ser Ala Ala Cys Gly His Ile Gly Val Leu Gly
                 725                 730                 735    
 Ala Leu Leu Gln Ser Ala Ala Ser Met Asp Ala Asn Pro Ala Thr Ala
             740                 745                 750        
 Asp Asn His Gly Tyr Thr Ala Leu His Trp Ala Cys Tyr Asn Gly His
         755                 760                 765            
 Glu Thr Cys Val Glu Leu Leu Leu Glu Gln Glu Val Phe Gln Lys Thr
     770                 775                 780                
 Glu Gly Asn Ala Phe Ser Pro Leu His Cys Ala Val Ile Asn Asp Asn
 785                 790                 795                 800
 Glu Gly Ala Ala Glu Met Leu Ile Asp Thr Leu Gly Ala Ser Ile Val
                 805                 810                 815    
 Asn Ala Thr Asp Ser Lys Gly Arg Thr Pro Leu His Ala Ala Ala Phe
             820                 825                 830        
 Thr Asp His Val Glu Cys Leu Gln Leu Leu Leu Ser His Asn Ala Gln
         835                 840                 845            
 Val Asn Ser Val Asp Ser Thr Gly Lys Thr Pro Leu Met Met Ala Ala
     850                 855                 860                
 Glu Asn Gly Gln Thr Asn Thr Val Glu Met Leu Val Ser Ser Ala Ser
 865                 870                 875                 880
 Ala Glu Leu Thr Leu Gln Asp Asn Ser Lys Asn Thr Ala Leu His Leu
                 885                 890                 895    
 Ala Cys Ser Lys Gly His Glu Thr Ser Ala Leu Leu Ile Leu Glu Lys
             900                 905                 910        
 Ile Thr Asp Arg Asn Leu Ile Asn Ala Thr Asn Ala Ala Leu Gln Thr
         915                 920                 925            
 Pro Leu His Val Ala Ala Arg Asn Gly Leu Thr Met Val Val Gln Glu
     930                 935                 940                
 Leu Leu Gly Lys Gly Ala Ser Val Leu Ala Val Asp Glu Asn Gly Tyr
 945                 950                 955                 960
 Thr Pro Ala Leu Ala Cys Ala Pro Asn Lys Asp Val Ala Asp Cys Leu
                 965                 970                 975    
 Ala Leu Ile Leu Ala Thr Met Met Pro Val Ser Ser Ser Ser Pro Leu
             980                 985                 990        
 Ser Ser Leu Thr Phe Asn Ala Ile Asn Arg Tyr Thr Asn Thr Ser Lys
         995                1000                1005            
 Thr Val Ser Phe Glu Ala Leu Pro Ile Met Arg Asn Glu Pro Ser Ser
    1010                1015                1020                
 Tyr Cys Ser Phe Asn Asn Ile Gly Gly Glu Gln Glu Tyr Leu Tyr Thr
1025                1030                1035                1040
 Asp Val Asp Glu Leu Asn Asp Ser Asp Ser Glu Thr Tyr
                1045                1050            



      <210> 344
      <211> 454
      <212> PRT
      <213> Homo sapiens


      <400> 344
 Met Gly Arg Thr Arg Glu Ala Gly Cys Val Ala Ala Gly Val Val Ile
   1               5                  10                  15    
 Gly Ala Gly Ala Cys Tyr Cys Val Tyr Arg Leu Ala Trp Gly Arg Asp
              20                  25                  30        
 Glu Asn Glu Lys Ile Trp Asp Glu Asp Glu Glu Ser Thr Asp Thr Ser
          35                  40                  45            
 Glu Ile Gly Val Glu Thr Val Lys Gly Ala Lys Thr Asn Ala Gly Ala
      50                  55                  60                
 Gly Ser Gly Ala Lys Leu Gln Gly Asp Ser Glu Val Lys Pro Glu Val
  65                  70                  75                  80
 Ser Leu Gly Leu Glu Asp Cys Pro Gly Val Lys Glu Lys Ala His Ser
                  85                  90                  95    
 Gly Ser His Ser Gly Gly Gly Leu Glu Ala Lys Ala Lys Ala Leu Phe
             100                 105                 110        
 Asn Thr Leu Lys Glu Gln Ala Ser Ala Lys Ala Gly Lys Gly Ala Arg
         115                 120                 125            
 Val Gly Thr Ile Ser Gly Asn Arg Thr Leu Ala Pro Ser Leu Pro Cys
     130                 135                 140                
 Pro Gly Gly Arg Gly Gly Gly Cys His Pro Thr Arg Ser Gly Ser Arg
 145                 150                 155                 160
 Ala Gly Gly Arg Ala Ser Gly Lys Ser Lys Gly Lys Ala Arg Ser Lys
                 165                 170                 175    
 Ser Thr Arg Ala Pro Ala Thr Thr Trp Pro Val Arg Arg Gly Lys Phe
             180                 185                 190        
 Asn Phe Pro Tyr Lys Ile Asp Asp Ile Leu Ser Ala Pro Asp Leu Gln
         195                 200                 205            
 Lys Val Leu Asn Ile Leu Glu Arg Thr Asn Asp Pro Phe Ile Gln Glu
     210                 215                 220                
 Val Ala Leu Val Thr Leu Gly Asn Asn Ala Ala Tyr Ser Phe Asn Gln
 225                 230                 235                 240
 Asn Ala Ile Arg Glu Leu Gly Gly Val Pro Ile Ile Ala Lys Leu Ile
                 245                 250                 255    
 Lys Thr Lys Asp Pro Ile Ile Arg Glu Lys Thr Tyr Asn Ala Leu Asn
             260                 265                 270        
 Asn Leu Ser Val Asn Ala Glu Asn Gln Gly Lys Ile Lys Thr Tyr Ile
         275                 280                 285            
 Ser Gln Val Cys Asp Asp Thr Met Val Cys Arg Leu Asp Ser Ala Val
     290                 295                 300                
 Gln Met Ala Gly Leu Arg Leu Leu Thr Asn Met Thr Val Thr Asn His
 305                 310                 315                 320
 Tyr Gln His Leu Leu Ser Tyr Ser Phe Pro Asp Phe Phe Ala Leu Leu
                 325                 330                 335    
 Phe Leu Gly Asn His Phe Thr Lys Ile Gln Ile Met Lys Leu Ile Ile
             340                 345                 350        
 Asn Phe Thr Glu Asn Pro Ala Met Thr Arg Glu Leu Val Ser Cys Lys
         355                 360                 365            
 Val Pro Ser Glu Leu Ile Ser Leu Phe Asn Lys Glu Trp Asp Arg Glu
     370                 375                 380                
 Ile Leu Leu Asn Ile Leu Thr Leu Phe Glu Asn Ile Asn Asp Asn Ile
 385                 390                 395                 400
 Lys Asn Glu Gly Leu Ala Ser Ser Arg Lys Glu Phe Ser Arg Ser Ser
                 405                 410                 415    
 Leu Phe Phe Leu Phe Lys Glu Ser Gly Val Cys Val Lys Lys Ile Lys
             420                 425                 430        
 Ala Leu Ala Asn His Asn Asp Leu Val Val Lys Val Lys Val Leu Lys
         435                 440                 445            
 Val Leu Thr Lys Leu
     450            



      <210> 345
      <211> 256
      <212> PRT
      <213> Homo sapiens


      <400> 345
 Met Thr Met Thr Thr Met Pro Glu Ser Leu Asn Ser Pro Val Ser Gly
   1               5                  10                  15    
 Lys Ala Val Phe Met Glu Phe Gly Pro Pro Asn Gln Gln Met Ser Pro
              20                  25                  30        
 Ser Pro Met Ser His Gly His Tyr Ser Met His Cys Leu His Ser Ala
          35                  40                  45            
 Gly His Ser Gln Pro Asp Gly Ala Tyr Ser Ser Ala Ser Ser Phe Ser
      50                  55                  60                
 Arg Pro Leu Gly Tyr Pro Tyr Val Asn Ser Val Ser Ser His Ala Ser
  65                  70                  75                  80
 Ser Pro Tyr Ile Ser Ser Val Gln Ser Tyr Pro Gly Ser Ala Ser Leu
                  85                  90                  95    
 Ala Gln Ser Arg Leu Glu Asp Pro Gly Ala Asp Ser Glu Lys Ser Thr
             100                 105                 110        
 Val Val Glu Gly Gly Glu Val Arg Phe Asn Gly Lys Gly Lys Lys Ile
         115                 120                 125            
 Arg Lys Pro Arg Thr Ile Tyr Ser Ser Leu Gln Leu Gln Ala Leu Asn
     130                 135                 140                
 Arg Arg Phe Gln Gln Thr Gln Tyr Leu Ala Leu Pro Glu Arg Ala Glu
 145                 150                 155                 160
 Leu Ala Ala Ser Leu Gly Leu Thr Gln Thr Gln Val Lys Ile Trp Phe
                 165                 170                 175    
 Gln Asn Lys Arg Ser Lys Phe Lys Lys Leu Met Lys Gln Gly Gly Ala
             180                 185                 190        
 Ala Leu Glu Gly Ser Ala Leu Ala Asn Gly Arg Ala Leu Ser Ala Gly
         195                 200                 205            
 Ser Pro Pro Val Pro Pro Gly Trp Asn Pro Asn Ser Ser Ser Gly Lys
     210                 215                 220                
 Gly Ser Gly Gly Asn Ala Gly Ser Tyr Ile Pro Ser Tyr Thr Ser Trp
 225                 230                 235                 240
 Tyr Pro Ser Ala His Gln Glu Ala Met Gln Gln Pro Gln Leu Met
                 245                 250                 255



      <210> 346
      <211> 1029
      <212> PRT
      <213> Homo sapiens


      <400> 346
 Met Arg Ala Ala Arg Ala Leu Leu Pro Leu Leu Leu Gln Ala Cys Trp
   1               5                  10                  15    
 Thr Ala Ala Gln Asp Glu Pro Glu Thr Pro Arg Ala Val Ala Phe Gln
              20                  25                  30        
 Asp Cys Pro Val Asp Leu Phe Phe Val Leu Asp Thr Ser Glu Ser Val
          35                  40                  45            
 Ala Leu Arg Leu Lys Pro Tyr Gly Ala Leu Val Asp Lys Val Lys Ser
      50                  55                  60                
 Phe Thr Lys Arg Phe Ile Asp Asn Leu Arg Asp Arg Tyr Tyr Arg Cys
  65                  70                  75                  80
 Asp Arg Asn Leu Val Trp Asn Ala Gly Ala Leu His Tyr Ser Asp Glu
                  85                  90                  95    
 Val Glu Ile Ile Gln Gly Leu Thr Arg Met Pro Gly Gly Arg Asp Ala
             100                 105                 110        
 Leu Lys Ser Ser Val Asp Ala Val Lys Tyr Phe Gly Lys Gly Thr Tyr
         115                 120                 125            
 Thr Asp Cys Ala Ile Lys Lys Gly Leu Glu Gln Leu Leu Val Gly Gly
     130                 135                 140                
 Ser His Leu Lys Glu Asn Lys Tyr Leu Ile Val Val Thr Asp Gly His
 145                 150                 155                 160
 Pro Leu Glu Gly Tyr Lys Glu Pro Cys Gly Gly Leu Glu Asp Ala Val
                 165                 170                 175    
 Asn Glu Ala Lys His Leu Gly Val Lys Val Phe Ser Val Ala Ile Thr
             180                 185                 190        
 Pro Asp His Leu Glu Pro Arg Leu Ser Ile Ile Ala Thr Asp His Thr
         195                 200                 205            
 Tyr Arg Arg Asn Phe Thr Ala Ala Asp Trp Gly Gln Ser Arg Asp Ala
     210                 215                 220                
 Glu Glu Ala Ile Ser Gln Thr Ile Asp Thr Ile Val Asp Met Ile Lys
 225                 230                 235                 240
 Asn Asn Val Glu Gln Val Cys Cys Ser Phe Glu Cys Gln Pro Ala Arg
                 245                 250                 255    
 Gly Pro Pro Gly Leu Arg Gly Asp Pro Gly Phe Glu Gly Glu Arg Gly
             260                 265                 270        
 Lys Pro Gly Leu Pro Gly Glu Lys Gly Glu Ala Gly Asp Pro Gly Arg
         275                 280                 285            
 Pro Gly Asp Leu Gly Pro Val Gly Tyr Gln Gly Met Lys Gly Glu Lys
     290                 295                 300                
 Gly Ser Arg Gly Glu Lys Gly Ser Arg Gly Pro Lys Gly Tyr Lys Gly
 305                 310                 315                 320
 Glu Lys Gly Lys Arg Gly Ile Asp Gly Val Asp Gly Val Lys Gly Glu
                 325                 330                 335    
 Met Gly Tyr Pro Gly Leu Pro Gly Cys Lys Gly Ser Pro Gly Phe Asp
             340                 345                 350        
 Gly Ile Gln Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ala Phe Gly
         355                 360                 365            
 Leu Lys Gly Glu Lys Gly Glu Pro Gly Ala Asp Gly Glu Ala Gly Arg
     370                 375                 380                
 Pro Gly Ser Ser Gly Pro Ser Gly Asp Glu Gly Gln Pro Gly Glu Pro
 385                 390                 395                 400
 Gly Pro Pro Gly Glu Lys Gly Glu Ala Gly Asp Glu Gly Asn Pro Gly
                 405                 410                 415    
 Pro Asp Gly Ala Pro Gly Glu Arg Gly Gly Pro Gly Glu Arg Gly Pro
             420                 425                 430        
 Arg Gly Thr Pro Gly Thr Arg Gly Pro Arg Gly Asp Pro Gly Glu Ala
         435                 440                 445            
 Gly Pro Gln Gly Asp Gln Gly Arg Glu Gly Pro Val Gly Val Pro Gly
     450                 455                 460                
 Asp Pro Gly Glu Ala Gly Pro Ile Gly Pro Lys Gly Tyr Arg Gly Asp
 465                 470                 475                 480
 Glu Gly Pro Pro Gly Ser Glu Gly Ala Arg Gly Ala Pro Gly Pro Ala
                 485                 490                 495    
 Gly Pro Pro Gly Asp Pro Gly Leu Met Gly Glu Arg Gly Glu Asp Gly
             500                 505                 510        
 Pro Ala Gly Asn Gly Thr Glu Gly Phe Pro Gly Phe Pro Gly Tyr Pro
         515                 520                 525            
 Gly Asn Arg Gly Ala Pro Gly Ile Asn Gly Thr Lys Gly Tyr Pro Gly
     530                 535                 540                
 Leu Lys Gly Asp Glu Gly Glu Ala Gly Asp Pro Gly Asp Asp Asn Asn
 545                 550                 555                 560
 Asp Ile Ala Pro Arg Gly Val Lys Gly Ala Lys Gly Tyr Arg Gly Pro
                 565                 570                 575    
 Glu Gly Pro Gln Gly Pro Pro Gly His Gln Gly Pro Pro Gly Pro Asp
             580                 585                 590        
 Glu Cys Glu Ile Leu Asp Ile Ile Met Lys Met Cys Ser Cys Cys Glu
         595                 600                 605            
 Cys Lys Cys Gly Pro Ile Asp Leu Leu Phe Val Leu Asp Ser Ser Glu
     610                 615                 620                
 Ser Ile Gly Leu Gln Asn Phe Glu Ile Ala Lys Asp Phe Val Val Lys
 625                 630                 635                 640
 Val Ile Asp Arg Leu Ser Arg Asp Glu Leu Val Lys Phe Glu Pro Gly
                 645                 650                 655    
 Gln Ser Tyr Ala Gly Val Val Gln Tyr Ser His Ser Gln Met Gln Glu
             660                 665                 670        
 His Val Ser Leu Arg Ser Pro Ser Ile Arg Asn Val Gln Glu Leu Lys
         675                 680                 685            
 Glu Ala Ile Lys Ser Leu Gln Trp Met Ala Gly Gly Thr Phe Thr Gly
     690                 695                 700                
 Glu Ala Leu Gln Tyr Thr Arg Asp Gln Leu Leu Pro Pro Ser Pro Asn
 705                 710                 715                 720
 Asn Arg Ile Ala Leu Val Ile Thr Asp Gly Arg Ser Asp Thr Gln Arg
                 725                 730                 735    
 Asp Thr Thr Pro Leu Asn Val Leu Cys Ser Pro Gly Ile Gln Val Val
             740                 745                 750        
 Ser Val Gly Ile Lys Asp Val Phe Asp Phe Ile Pro Gly Ser Asp Gln
         755                 760                 765            
 Leu Asn Val Ile Ser Cys Gln Gly Leu Ala Pro Ser Gln Gly Arg Pro
     770                 775                 780                
 Gly Leu Ser Leu Val Lys Glu Asn Tyr Ala Glu Leu Leu Glu Asp Ala
 785                 790                 795                 800
 Phe Leu Lys Asn Val Thr Ala Gln Ile Cys Ile Asp Lys Lys Cys Pro
                 805                 810                 815    
 Asp Tyr Thr Cys Pro Ile Thr Phe Ser Ser Pro Ala Asp Ile Thr Ile
             820                 825                 830        
 Leu Leu Asp Gly Ser Ala Ser Val Gly Ser His Asn Phe Asp Thr Thr
         835                 840                 845            
 Lys Arg Phe Ala Lys Arg Leu Ala Glu Arg Phe Leu Thr Ala Gly Arg
     850                 855                 860                
 Thr Asp Pro Ala His Asp Val Arg Val Ala Val Val Gln Tyr Ser Gly
 865                 870                 875                 880
 Thr Gly Gln Gln Arg Pro Glu Arg Ala Ser Leu Gln Phe Leu Gln Asn
                 885                 890                 895    
 Tyr Thr Ala Leu Ala Ser Ala Val Asp Ala Met Asp Phe Ile Asn Asp
             900                 905                 910        
 Ala Thr Asp Val Asn Asp Ala Leu Gly Tyr Val Thr Arg Phe Tyr Arg
         915                 920                 925            
 Glu Ala Ser Ser Gly Ala Ala Lys Lys Arg Leu Leu Leu Phe Ser Asp
     930                 935                 940                
 Gly Asn Ser Gln Gly Ala Thr Pro Ala Ala Ile Glu Lys Ala Val Gln
 945                 950                 955                 960
 Glu Ala Gln Arg Ala Gly Ile Glu Ile Phe Val Val Val Val Gly Arg
                 965                 970                 975    
 Gln Val Asn Glu Pro His Ile Arg Val Leu Val Thr Gly Lys Thr Ala
             980                 985                 990        
 Glu Tyr Asp Val Ala Tyr Gly Glu Ser His Leu Phe Arg Val Pro Ser
         995                1000                1005            
 Tyr Gln Ala Leu Leu Arg Gly Val Phe His Gln Thr Val Ser Arg Lys
    1010                1015                1020                
 Val Ala Leu Gly
1025            



      <210> 347
      <211> 187
      <212> PRT
      <213> Homo sapiens


      <400> 347
 Met Ile Asp Leu Tyr Pro Arg Asp Ser Trp Asn Phe Val Phe Gly Gln
   1               5                  10                  15    
 Ala Ser Leu Thr Asp Gly Val Gly Ile Phe Ser Phe Ala Arg Tyr Gly
              20                  25                  30        
 Ser Asp Phe Tyr Ser Met His Tyr Lys Gly Lys Val Lys Lys Leu Lys
          35                  40                  45            
 Lys Thr Ser Ser Ser Asp Tyr Ser Ile Phe Asp Asn Tyr Tyr Ile Pro
      50                  55                  60                
 Glu Ile Thr Ser Val Leu Leu Leu Arg Ser Cys Lys Thr Leu Thr His
  65                  70                  75                  80
 Glu Ile Gly His Ile Phe Gly Leu Arg His Cys Gln Trp Leu Ala Cys
                  85                  90                  95    
 Leu Met Gln Gly Ser Asn His Leu Glu Glu Ala Asp Arg Arg Pro Leu
             100                 105                 110        
 Asn Leu Cys Pro Ile Cys Leu His Lys Leu Gln Cys Ala Val Gly Phe
         115                 120                 125            
 Ser Ile Val Glu Arg Tyr Lys Ala Leu Val Arg Trp Ile Asp Asp Glu
     130                 135                 140                
 Ser Ser Asp Thr Pro Gly Ala Thr Pro Glu His Ser His Glu Asp Asn
 145                 150                 155                 160
 Gly Asn Leu Pro Lys Pro Val Glu Ala Phe Lys Glu Trp Lys Glu Trp
                 165                 170                 175    
 Ile Ile Lys Cys Leu Ala Val Leu Gln Lys
             180                 185    



      <210> 348
      <211> 46
      <212> PRT
      <213> Homo sapiens


      <400> 348
 Met Gln Gly Arg Leu Phe Ser Leu His Val Phe Cys Val Val Leu Lys
   1               5                  10                  15    
 Leu Leu Ala Gly Ala Val Arg Gln Asp Lys Glu Arg Lys Tyr Arg Cys
              20                  25                  30        
 Thr Gly Lys Glu Glu Glu Thr Leu Pro Leu Phe Phe Arg
          35                  40                  45



      <210> 349
      <211> 93
      <212> PRT
      <213> Homo sapiens


      <400> 349
 Met Tyr Ile Lys Pro Ser Thr Arg Lys Ser Gly Tyr Ser Pro Gln Gln
   1               5                  10                  15    
 Val Ala Val Ile His Cys Lys Gly His Gln Lys Glu Asn Thr Ala Val
              20                  25                  30        
 Ala His Ser Asn Gln Lys Ala Asp Ser Ala Ala Gln Val Thr Ala Arg
          35                  40                  45            
 Leu Ser Val Thr Pro Pro Asn Leu Leu Pro Thr Val Ser Phe Pro Gln
      50                  55                  60                
 Pro Asp Leu Pro Asp Asn Pro Val Tyr Ser Thr Thr Thr Glu Lys Leu
  65                  70                  75                  80
 Ala Ser Asp Leu Arg Ala Asn Lys Asn Gln Glu Ser
                  85                  90        



      <210> 350
      <211> 579
      <212> PRT
      <213> Homo sapiens


      <400> 350
 Met Trp Pro Arg Ala Ala His Leu Pro Gly Thr Arg Trp His Gly Arg
   1               5                  10                  15    
 Pro Thr Gly His Pro Pro Pro Pro Pro Met Ser Leu Pro Ala Ser Ala
              20                  25                  30        
 Met Pro Val Glu Gly Val Gly Gly Asp Ala Leu Trp Ala Gly His Ala
          35                  40                  45            
 Ser Gly Tyr Leu Gly Gly Gly Gln Leu Trp Ala Thr Ser Glu Tyr Ile
      50                  55                  60                
 Pro Leu Cys Ser Ser Asn Ala Glu Ser Leu Asp Arg Leu Leu Pro Pro
  65                  70                  75                  80
 Val Gly Thr Gly Arg Ser Pro Arg Lys Arg Thr Thr Ser Gln Cys Lys
                  85                  90                  95    
 Ser Glu Pro Pro Leu Leu Arg Thr Ser Lys Arg Thr Ile Tyr Thr Ala
             100                 105                 110        
 Gly Arg Pro Pro Trp Tyr Asn Glu His Gly Thr Gln Ser Lys Glu Ala
         115                 120                 125            
 Phe Ala Ile Gly Leu Gly Gly Gly Ser Ala Ser Gly Lys Thr Thr Val
     130                 135                 140                
 Ala Arg Met Ile Ile Glu Ala Leu Asp Val Pro Trp Val Val Leu Leu
 145                 150                 155                 160
 Ser Met Asp Ser Phe Tyr Lys Val Leu Thr Glu Gln Gln Gln Glu Gln
                 165                 170                 175    
 Ala Ala His Asn Asn Phe Asn Phe Asp His Pro Asp Ala Phe Asp Phe
             180                 185                 190        
 Asp Leu Ile Ile Ser Thr Leu Lys Lys Leu Lys Gln Gly Lys Ser Val
         195                 200                 205            
 Lys Val Pro Ile Tyr Asp Phe Thr Thr His Ser Arg Lys Lys Asp Trp
     210                 215                 220                
 Lys Thr Leu Tyr Gly Ala Asn Val Ile Ile Phe Glu Gly Ile Met Ala
 225                 230                 235                 240
 Phe Ala Asp Lys Thr Leu Leu Glu Leu Leu Asp Met Lys Ile Phe Val
                 245                 250                 255    
 Asp Thr Asp Ser Asp Ile Arg Leu Val Arg Arg Leu Arg Arg Asp Ile
             260                 265                 270        
 Ser Glu Arg Gly Arg Asp Ile Glu Gly Val Ile Lys Gln Tyr Asn Lys
         275                 280                 285            
 Phe Val Lys Pro Ser Phe Asp Gln Tyr Ile Gln Pro Thr Met Arg Leu
     290                 295                 300                
 Ala Asp Ile Val Val Pro Arg Gly Ser Gly Asn Thr Val Ala Ile Asp
 305                 310                 315                 320
 Leu Ile Val Gln His Val His Ser Gln Leu Glu Glu Arg Glu Leu Ser
                 325                 330                 335    
 Val Arg Ala Ala Leu Ala Ser Ala His Gln Cys His Pro Leu Pro Arg
             340                 345                 350        
 Thr Leu Ser Val Leu Lys Ser Thr Pro Gln Val Arg Gly Met His Thr
         355                 360                 365            
 Ile Ile Arg Asp Lys Glu Thr Ser Arg Asp Glu Phe Ile Phe Tyr Ser
     370                 375                 380                
 Lys Arg Leu Met Arg Leu Leu Ile Glu His Ala Leu Ser Phe Leu Pro
 385                 390                 395                 400
 Phe Gln Asp Cys Val Val Gln Thr Pro Gln Gly Gln Asp Tyr Ala Gly
                 405                 410                 415    
 Lys Cys Tyr Ala Gly Lys Gln Ile Thr Gly Val Ser Ile Leu Arg Ala
             420                 425                 430        
 Gly Glu Thr Met Glu Pro Ala Leu Arg Ala Val Cys Lys Asp Val Arg
         435                 440                 445            
 Ile Gly Thr Ile Leu Ile Gln Thr Asn Gln Leu Thr Gly Glu Pro Glu
     450                 455                 460                
 Leu His Tyr Leu Arg Leu Pro Lys Asp Ile Ser Asp Asp His Val Ile
 465                 470                 475                 480
 Leu Met Asp Cys Thr Val Ser Thr Gly Ala Ala Ala Met Met Ala Val
                 485                 490                 495    
 Arg Val Leu Leu Asp His Asp Val Pro Glu Asp Lys Ile Phe Leu Leu
             500                 505                 510        
 Ser Leu Leu Met Ala Glu Met Gly Val His Ser Val Ala Tyr Ala Phe
         515                 520                 525            
 Pro Arg Val Arg Ile Ile Thr Thr Ala Val Asp Lys Arg Val Asn Asp
     530                 535                 540                
 Leu Phe Arg Ile Ile Pro Gly Ile Gly Asn Phe Gly Asp Arg Tyr Phe
 545                 550                 555                 560
 Gly Thr Asp Ala Val Pro Asp Gly Ser Asp Glu Glu Glu Val Ala Tyr
                 565                 570                 575    
 Thr Gly
        



      <210> 351
      <211> 376
      <212> PRT
      <213> Homo sapiens


      <400> 351
 Met Ile Leu Gly Arg Val Ile Met Gln Ile Ile Lys Asp Met Val Leu
   1               5                  10                  15    
 Ser Arg Thr Arg Gly Ala Gln Leu Trp Arg Ser Leu Ser Glu Ser Trp
              20                  25                  30        
 Glu Val Ile Asn Ser Lys Pro Asp Glu Arg Pro Arg Leu Ser His Cys
          35                  40                  45            
 Ile Ala Glu Ser Trp Met Asn Phe Ser Ile Phe Leu Gln Glu Met Ser
      50                  55                  60                
 Leu Phe Lys Gln Gln Ser Pro Gly Lys Phe Cys Leu Leu Val Cys Ser
  65                  70                  75                  80
 Val Cys Thr Phe Phe Thr Ile Leu Gly Ser Tyr Ile Pro Gly Val Ile
                  85                  90                  95    
 Leu Ser Tyr Leu Leu Leu Leu Cys Ala Phe Leu Cys Pro Leu Phe Lys
             100                 105                 110        
 Cys Asn Asp Ile Gly Gln Lys Ile Tyr Ser Lys Ile Lys Ser Val Leu
         115                 120                 125            
 Leu Lys Leu Asp Phe Gly Ile Gly Glu Tyr Ile Asn Gln Lys Lys Arg
     130                 135                 140                
 Glu Arg Ser Glu Ala Asp Lys Glu Lys Ser His Lys Asp Asp Ser Glu
 145                 150                 155                 160
 Leu Asp Phe Ser Ala Leu Cys Pro Lys Ile Ser Leu Thr Val Ala Ala
                 165                 170                 175    
 Lys Glu Leu Ser Val Ser Asp Thr Asp Val Ser Glu Val Ser Trp Thr
             180                 185                 190        
 Asp Asn Gly Thr Phe Asn Leu Ser Glu Gly Tyr Thr Pro Gln Thr Asp
         195                 200                 205            
 Thr Ser Asp Asp Leu Asp Arg Pro Ser Glu Glu Val Phe Ser Arg Asp
     210                 215                 220                
 Leu Ser Asp Phe Pro Ser Leu Glu Asn Gly Met Gly Thr Asn Asp Glu
 225                 230                 235                 240
 Asp Glu Leu Ser Leu Gly Leu Pro Thr Glu Leu Lys Arg Lys Lys Glu
                 245                 250                 255    
 Gln Leu Asp Ser Gly His Arg Pro Ser Lys Glu Thr Gln Ser Ala Ala
             260                 265                 270        
 Gly Leu Thr Leu Pro Leu Asn Ser Asp Gln Thr Phe His Leu Met Ser
         275                 280                 285            
 Asn Leu Ala Gly Asp Val Ile Thr Ala Ala Val Thr Ala Ala Ile Lys
     290                 295                 300                
 Asp Gln Leu Glu Gly Val Gln Gln Ala Leu Ser Gln Ala Ala Pro Ile
 305                 310                 315                 320
 Pro Glu Glu Asp Thr Asp Thr Glu Glu Gly Asp Asp Phe Glu Leu Leu
                 325                 330                 335    
 Asp Gln Ser Glu Leu Asp Gln Ile Glu Ser Glu Leu Gly Leu Thr Gln
             340                 345                 350        
 Asp Gln Glu Ala Glu Ala Gln Gln Asn Lys Lys Ser Ser Gly Phe Leu
         355                 360                 365            
 Ser Asn Leu Leu Gly Gly His
     370                 375



      <210> 352
      <211> 480
      <212> PRT
      <213> Homo sapiens


      <400> 352
 Met Ala Val Leu Gly Val Gln Leu Val Val Thr Leu Leu Thr Ala Thr
   1               5                  10                  15    
 Leu Met His Arg Leu Ala Pro His Cys Ser Phe Ala Arg Trp Leu Leu
              20                  25                  30        
 Cys Asn Gly Ser Leu Phe Arg Tyr Lys His Pro Ser Glu Glu Glu Leu
          35                  40                  45            
 Arg Ala Leu Ala Gly Lys Pro Arg Pro Arg Gly Arg Lys Glu Arg Trp
      50                  55                  60                
 Ala Asn Gly Leu Ser Glu Glu Lys Pro Leu Ser Val Pro Arg Asp Ala
  65                  70                  75                  80
 Pro Phe Gln Leu Glu Thr Cys Pro Leu Thr Thr Val Asp Ala Leu Val
                  85                  90                  95    
 Leu Arg Phe Phe Leu Glu Tyr Gln Trp Phe Val Asp Phe Ala Val Tyr
             100                 105                 110        
 Ser Gly Gly Val Tyr Leu Phe Thr Glu Ala Tyr Tyr Tyr Met Leu Gly
         115                 120                 125            
 Pro Ala Lys Glu Thr Asn Ile Ala Val Phe Trp Cys Leu Leu Thr Val
     130                 135                 140                
 Thr Phe Ser Ile Lys Met Phe Leu Thr Val Thr Arg Leu Tyr Phe Ser
 145                 150                 155                 160
 Ala Glu Glu Gly Gly Glu Arg Ser Val Cys Leu Thr Phe Ala Phe Leu
                 165                 170                 175    
 Phe Leu Leu Leu Ala Met Leu Val Gln Val Val Arg Glu Glu Thr Leu
             180                 185                 190        
 Glu Leu Gly Leu Glu Pro Gly Leu Ala Ser Met Thr Gln Asn Leu Glu
         195                 200                 205            
 Pro Leu Leu Lys Lys Gln Gly Trp Asp Trp Ala Leu Pro Val Ala Lys
     210                 215                 220                
 Leu Ala Ile Arg Val Gly Leu Ala Val Val Gly Ser Val Leu Gly Ala
 225                 230                 235                 240
 Phe Leu Thr Phe Pro Gly Leu Arg Leu Ala Gln Thr His Arg Asp Ala
                 245                 250                 255    
 Leu Thr Met Ser Glu Asp Arg Pro Met Leu Gln Phe Leu Leu His Thr
             260                 265                 270        
 Ser Phe Leu Ser Pro Leu Phe Ile Leu Trp Leu Trp Thr Lys Pro Ile
         275                 280                 285            
 Ala Arg Asp Phe Leu His Gln Pro Pro Phe Gly Glu Thr Arg Phe Ser
     290                 295                 300                
 Leu Leu Ser Asp Ser Ala Phe Asp Ser Gly Arg Leu Trp Leu Leu Val
 305                 310                 315                 320
 Val Leu Cys Leu Leu Arg Leu Ala Val Thr Arg Pro His Leu Gln Ala
                 325                 330                 335    
 Tyr Leu Cys Leu Ala Lys Ala Arg Val Glu Gln Leu Arg Arg Glu Ala
             340                 345                 350        
 Gly Arg Ile Glu Ala Arg Glu Ile Gln Gln Arg Val Val Arg Val Tyr
         355                 360                 365            
 Cys Tyr Val Thr Val Val Ser Leu Gln Tyr Leu Thr Pro Leu Ile Leu
     370                 375                 380                
 Thr Leu Asn Cys Thr Leu Leu Leu Lys Thr Leu Gly Gly Tyr Ser Trp
 385                 390                 395                 400
 Gly Leu Gly Pro Ala Pro Leu Leu Ser Pro Asp Pro Ser Ser Ala Ser
                 405                 410                 415    
 Ala Ala Pro Ile Gly Ser Gly Glu Asp Glu Val Gln Gln Thr Ala Ala
             420                 425                 430        
 Arg Ile Ala Gly Ala Leu Gly Gly Leu Leu Thr Pro Leu Phe Leu Arg
         435                 440                 445            
 Gly Val Leu Ala Tyr Leu Ile Trp Trp Thr Ala Ala Cys Gln Leu Leu
     450                 455                 460                
 Ala Ser Leu Phe Gly Leu Tyr Phe His Gln His Leu Ala Gly Ser
 465                 470                 475                



      <210> 353
      <211> 245
      <212> PRT
      <213> Homo sapiens


      <400> 353
 Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser
   1               5                  10                  15    
 Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp
              20                  25                  30        
 Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp
          35                  40                  45            
 Ser Gly Lys Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln
      50                  55                  60                
 Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr
  65                  70                  75                  80
 Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala
                  85                  90                  95    
 Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu
             100                 105                 110        
 Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln
         115                 120                 125            
 Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro
     130                 135                 140                
 Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu
 145                 150                 155                 160
 Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala
                 165                 170                 175    
 Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu
             180                 185                 190        
 Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala
         195                 200                 205            
 Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu
     210                 215                 220                
 Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys
 225                 230                 235                 240
 Leu Asn Thr Gln
                



      <210> 354
      <211> 519
      <212> PRT
      <213> Homo sapiens


      <400> 354
 Met Glu Ser Pro Glu Glu Pro Gly Ala Ser Met Asp Glu Asn Tyr Phe
   1               5                  10                  15    
 Val Asn Tyr Thr Phe Lys Asp Arg Ser His Ser Gly Arg Val Ala Gln
              20                  25                  30        
 Gly Ile Met Lys Leu Cys Leu Glu Glu Glu Leu Phe Ala Asp Val Thr
          35                  40                  45            
 Ile Ser Val Glu Gly Arg Glu Phe Gln Leu His Arg Leu Val Leu Ser
      50                  55                  60                
 Ala Gln Ser Cys Phe Phe Arg Ser Met Phe Thr Ser Asn Leu Lys Glu
  65                  70                  75                  80
 Ala His Asn Arg Val Ile Val Leu Gln Asp Val Ser Glu Ser Val Phe
                  85                  90                  95    
 Gln Leu Leu Val Asp Tyr Ile Tyr His Gly Thr Val Lys Leu Arg Ala
             100                 105                 110        
 Glu Glu Leu Gln Glu Ile Tyr Glu Val Ser Asp Met Tyr Gln Leu Thr
         115                 120                 125            
 Ser Leu Phe Glu Glu Cys Ser Arg Phe Leu Ala Arg Thr Val Gln Val
     130                 135                 140                
 Gly Asn Cys Leu Gln Val Met Trp Leu Ala Asp Arg His Ser Asp Pro
 145                 150                 155                 160
 Glu Leu Tyr Thr Ala Ala Lys His Cys Ala Lys Thr His Leu Ala Gln
                 165                 170                 175    
 Leu Gln Asn Thr Glu Glu Phe Leu His Leu Pro His Arg Leu Leu Thr
             180                 185                 190        
 Asp Ile Ile Ser Asp Gly Val Pro Cys Ser Gln Asn Pro Thr Glu Ala
         195                 200                 205            
 Ile Glu Ala Trp Ile Asn Phe Asn Lys Glu Glu Arg Glu Ala Phe Ala
     210                 215                 220                
 Glu Ser Leu Arg Thr Ser Leu Lys Glu Ile Gly Glu Asn Val His Ile
 225                 230                 235                 240
 Tyr Leu Ile Gly Lys Glu Ser Ser Arg Thr His Ser Leu Ala Val Ser
                 245                 250                 255    
 Leu His Cys Ala Glu Asp Asp Ser Ile Ser Val Ser Gly Gln Asn Ser
             260                 265                 270        
 Leu Cys His Gln Ile Thr Ala Ala Cys Lys His Gly Gly Asp Leu Tyr
         275                 280                 285            
 Val Val Gly Gly Ser Ile Pro Arg Arg Met Trp Lys Cys Asn Asn Ala
     290                 295                 300                
 Thr Val Asp Trp Glu Trp Cys Ala Pro Leu Pro Arg Asp Arg Leu Gln
 305                 310                 315                 320
 His Thr Leu Val Ser Val Pro Gly Lys Asp Ala Ile Tyr Ser Leu Gly
                 325                 330                 335    
 Gly Lys Thr Leu Gln Asp Thr Leu Ser Asn Ala Val Ile Tyr Tyr Arg
             340                 345                 350        
 Val Gly Asp Asn Val Trp Thr Glu Thr Thr Gln Leu Glu Val Ala Val
         355                 360                 365            
 Ser Gly Ala Ala Gly Ala Asn Leu Asn Gly Ile Ile Tyr Leu Leu Gly
     370                 375                 380                
 Gly Glu Glu Asn Asp Leu Asp Phe Phe Thr Lys Pro Ser Arg Leu Ile
 385                 390                 395                 400
 Gln Cys Phe Asp Thr Glu Thr Asp Lys Cys His Val Lys Pro Tyr Val
                 405                 410                 415    
 Leu Pro Phe Ala Gly Arg Met His Ala Ala Val His Lys Asp Leu Val
             420                 425                 430        
 Phe Ile Val Ala Glu Gly Asp Ser Leu Val Cys Tyr Asn Pro Leu Leu
         435                 440                 445            
 Asp Ser Phe Thr Arg Leu Cys Leu Pro Glu Ala Trp Ser Ser Ala Pro
     450                 455                 460                
 Ser Leu Trp Lys Ile Ala Ser Cys Asn Gly Ser Ile Tyr Val Phe Arg
 465                 470                 475                 480
 Asp Arg Tyr Lys Lys Gly Asp Ala Asn Thr Tyr Lys Leu Asp Pro Ala
                 485                 490                 495    
 Thr Ser Ala Val Thr Val Thr Arg Gly Ile Lys Val Leu Leu Thr Asn
             500                 505                 510        
 Leu Gln Phe Val Leu Ala
         515            



      <210> 355
      <211> 585
      <212> PRT
      <213> Homo sapiens


      <400> 355
 Met Lys Ala Leu Met Asn Glu Lys Ala Gln Ala Ala Leu Val Glu Phe
   1               5                  10                  15    
 Val Glu Asp Val Asn His Ala Ala Ile Pro Arg Glu Ile Pro Arg Lys
              20                  25                  30        
 Asp Gly Val Trp Arg Val Leu Trp Lys Asp Arg Ala Gln Asp Thr Arg
          35                  40                  45            
 Val Leu Arg Gln Met Thr Arg Leu Leu Leu Asp Asp Gly Pro Thr Gln
      50                  55                  60                
 Ala Ala Glu Ala Gly Thr Pro Gly Glu Ala Pro Thr Pro Pro Ala Ser
  65                  70                  75                  80
 Glu Thr Gln Ala Gln Asp Ser Gly Glu Val Thr Gly His Ala Gly Ser
                  85                  90                  95    
 Leu Leu Gly Ala Pro Arg Asn Pro Arg Arg Gly Arg Arg Gly Arg Arg
             100                 105                 110        
 Asn Arg Thr Arg Arg Asn Arg Leu Thr Gln Lys Gly Lys Lys Arg Ser
         115                 120                 125            
 Arg Gly Gly Arg Pro Ser Ala Pro Ala Arg Ser Glu Ala Glu Asp Ser
     130                 135                 140                
 Ser Asp Glu Ser Leu Gly Ile Val Ile Glu Glu Ile Asp Gln Gly Asp
 145                 150                 155                 160
 Leu Ser Gly Glu Glu Asp Gln Ser Ala Leu Tyr Ala Thr Leu Gln Ala
                 165                 170                 175    
 Ala Ala Arg Glu Leu Val Arg Gln Trp Ala Pro Cys Asn Ser Glu Gly
             180                 185                 190        
 Glu Glu Asp Gly Pro Arg Glu Phe Leu Ala Leu Val Thr Val Thr Asp
         195                 200                 205            
 Lys Ser Lys Lys Glu Glu Ala Glu Lys Glu Pro Ala Gly Ala Glu Ser
     210                 215                 220                
 Ile Arg Leu Asn Thr Lys Glu Asp Lys Asn Gly Val Pro Asp Leu Val
 225                 230                 235                 240
 Ala Leu Leu Ala Val Arg Asp Thr Pro Asp Glu Glu Pro Val Asp Ser
                 245                 250                 255    
 Asp Thr Ser Glu Ser Asp Ser Gln Glu Ser Gly Asp Gln Glu Thr Glu
             260                 265                 270        
 Glu Leu Asp Asn Pro Glu Phe Val Ala Ile Val Ala Tyr Thr Asp Pro
         275                 280                 285            
 Ser Asp Pro Trp Ala Arg Glu Glu Met Leu Lys Ile Ala Ser Val Ile
     290                 295                 300                
 Glu Ser Leu Gly Trp Ser Asp Glu Lys Asp Lys Arg Asp Pro Leu Arg
 305                 310                 315                 320
 Gln Val Leu Ser Val Met Ser Lys Asp Thr Asn Gly Thr Arg Val Lys
                 325                 330                 335    
 Val Glu Glu Ala Gly Arg Glu Val Asp Ala Val Val Leu Arg Lys Ala
             340                 345                 350        
 Gly Asp Asp Gly Asp Leu Arg Glu Cys Ile Ser Thr Leu Ala Gln Pro
         355                 360                 365            
 Asp Leu Pro Pro Gln Ala Lys Lys Ala Gly Arg Gly Leu Phe Gly Gly
     370                 375                 380                
 Trp Ser Glu His Arg Glu Asp Glu Gly Gly Leu Leu Glu Leu Val Ala
 385                 390                 395                 400
 Leu Leu Ala Ala Gln Asp Met Ala Glu Val Met Lys Glu Glu Lys Glu
                 405                 410                 415    
 Asn Ala Trp Glu Gly Gly Lys Tyr Lys Tyr Pro Lys Gly Lys Leu Gly
             420                 425                 430        
 Glu Val Leu Ala Leu Leu Ala Ala Arg Glu Asn Met Gly Ser Asn Glu
         435                 440                 445            
 Gly Ser Glu Glu Ala Ser Asp Glu Gln Ser Glu Glu Glu Ser Glu Asp
     450                 455                 460                
 Thr Glu Ser Glu Ala Ser Glu Pro Glu Asp Arg Ala Ser Arg Lys Pro
 465                 470                 475                 480
 Arg Ala Lys Arg Ala Arg Thr Ala Pro Arg Gly Leu Thr Pro Ala Gly
                 485                 490                 495    
 Ala Pro Pro Thr Ala Ser Gly Ala Arg Lys Thr Arg Ala Gly Gly Arg
             500                 505                 510        
 Gly Arg Gly Arg Gly Arg Gly Val Thr Pro Glu Lys Lys Ala Gly Ser
         515                 520                 525            
 Arg Gly Ser Ala Gln Asp Asp Ala Ala Gly Ser Arg Lys Lys Lys Gly
     530                 535                 540                
 Ser Ala Gly Ser Gly Ala His Ala Arg Ala Gly Glu Ala Lys Gly Gln
 545                 550                 555                 560
 Ala Pro Thr Gly Ser Lys Ala Ala Arg Gly Lys Lys Ala Arg Arg Gly
                 565                 570                 575    
 Arg Arg Leu Pro Pro Lys Cys Arg
             580                



      <210> 356
      <211> 616
      <212> PRT
      <213> Homo sapiens


      <400> 356
 Met Ala Glu Ser Gly Gly Ser Ser Gly Gly Ala Gly Gly Gly Gly Ala
   1               5                  10                  15    
 Phe Gly Ala Gly Pro Gly Pro Glu Arg Pro Asn Ser Thr Ala Asp Lys
              20                  25                  30        
 Asn Gly Ala Leu Lys Cys Thr Phe Ser Ala Pro Ser His Ser Thr Ser
          35                  40                  45            
 Leu Leu Gln Gly Leu Ala Thr Leu Arg Ala Gln Gly Gln Leu Leu Asp
      50                  55                  60                
 Val Val Leu Thr Ile Asn Arg Glu Ala Phe Pro Ala His Lys Val Val
  65                  70                  75                  80
 Leu Ala Ala Cys Ser Asp Tyr Phe Arg Ala Met Phe Thr Gly Gly Met
                  85                  90                  95    
 Arg Glu Ala Ser Gln Asp Val Ile Glu Leu Lys Gly Val Ser Ala Arg
             100                 105                 110        
 Gly Leu Arg His Ile Ile Asp Phe Ala Tyr Ser Ala Glu Val Thr Leu
         115                 120                 125            
 Asp Leu Asp Cys Val Gln Asp Val Leu Gly Ala Ala Val Phe Leu Gln
     130                 135                 140                
 Met Leu Pro Val Val Glu Leu Cys Glu Glu Phe Leu Lys Ala Ala Met
 145                 150                 155                 160
 Ser Val Glu Thr Cys Leu Asn Ile Gly Gln Met Ala Thr Thr Phe Ser
                 165                 170                 175    
 Leu Ala Ser Leu Arg Glu Ser Val Asp Ala Phe Thr Phe Arg His Phe
             180                 185                 190        
 Leu Gln Ile Ala Glu Glu Glu Asp Phe Leu Arg Leu Pro Leu Glu Arg
         195                 200                 205            
 Leu Val Phe Phe Leu Gln Ser Asn Arg Leu Gln Ser Cys Ala Glu Ile
     210                 215                 220                
 Asp Leu Phe Arg Ala Ala Val Arg Trp Leu Gln His Asp Pro Ala Arg
 225                 230                 235                 240
 Arg Pro Arg Ala Ser His Val Leu Cys His Ile Arg Phe Pro Leu Met
                 245                 250                 255    
 Gln Ser Ser Glu Leu Val Asp Ser Val Gln Thr Leu Asp Ile Met Val
             260                 265                 270        
 Glu Asp Val Leu Cys Arg Gln Tyr Leu Leu Glu Ala Phe Asn Tyr Gln
         275                 280                 285            
 Val Leu Pro Phe Arg Gln His Glu Met Gln Ser Pro Arg Thr Ala Val
     290                 295                 300                
 Arg Ser Asp Val Pro Ser Leu Val Thr Phe Gly Gly Thr Pro Tyr Thr
 305                 310                 315                 320
 Asp Ser Asp Arg Ser Val Ser Ser Lys Val Tyr Gln Leu Pro Glu Pro
                 325                 330                 335    
 Gly Ala Arg His Phe Arg Glu Leu Thr Glu Met Glu Val Gly Cys Ser
             340                 345                 350        
 His Thr Cys Val Ala Val Leu Asp Asn Phe Val Tyr Val Ala Gly Gly
         355                 360                 365            
 Gln His Leu Gln Tyr Arg Ser Gly Glu Gly Ala Val Asp Ala Cys Tyr
     370                 375                 380                
 Arg Tyr Asp Pro His Leu Asn Arg Trp Leu Arg Leu Gln Ala Met Gln
 385                 390                 395                 400
 Glu Ser Arg Ile Gln Phe Gln Leu Asn Val Leu Cys Gly Met Val Tyr
                 405                 410                 415    
 Ala Thr Gly Gly Arg Asn Arg Ala Gly Ser Leu Ala Ser Val Glu Arg
             420                 425                 430        
 Tyr Cys Pro Arg Arg Asn Glu Trp Gly Tyr Ala Cys Ser Leu Lys Arg
         435                 440                 445            
 Arg Thr Trp Gly His Ala Gly Ala Ala Ser Gly Gly Arg Leu Tyr Ile
     450                 455                 460                
 Ser Gly Gly Tyr Gly Ile Ser Val Glu Asp Lys Lys Ala Leu His Cys
 465                 470                 475                 480
 Tyr Asp Pro Val Ala Asp Gln Trp Glu Phe Lys Ala Pro Met Ser Glu
                 485                 490                 495    
 Pro Arg Val Leu His Ala Met Val Gly Ala Gly Gly Arg Ile Tyr Ala
             500                 505                 510        
 Leu Gly Gly Arg Met Asp His Ala Asp Arg Cys Phe Asp Val Leu Ala
         515                 520                 525            
 Val Glu Tyr Tyr Val Pro Glu Thr Asp Gln Trp Thr Ser Val Ser Pro
     530                 535                 540                
 Met Arg Ala Gly Gln Ser Glu Ala Gly Cys Cys Leu Leu Glu Arg Lys
 545                 550                 555                 560
 Ile Tyr Ile Val Gly Gly Tyr Asn Trp Arg Leu Asn Asn Val Thr Gly
                 565                 570                 575    
 Ile Val Gln Val Tyr Asn Thr Asp Thr Asp Glu Trp Glu Arg Asp Leu
             580                 585                 590        
 His Phe Pro Glu Ser Phe Ala Gly Ile Ala Cys Ala Pro Val Leu Leu
         595                 600                 605            
 Pro Arg Ala Gly Thr Arg Arg
     610                 615



      <210> 357
      <211> 711
      <212> PRT
      <213> Homo sapiens


      <400> 357
 Met Ser Ala Gln Gly Asp Cys Glu Phe Leu Val Gln Arg Ala Arg Glu
   1               5                  10                  15    
 Leu Val Pro Gln Asp Leu Trp Ala Ala Lys Ala Trp Leu Ile Thr Ala
              20                  25                  30        
 Arg Ser Leu Tyr Pro Ala Asp Phe Asn Ile Gln Tyr Glu Met Tyr Thr
          35                  40                  45            
 Ile Glu Arg Asn Ala Glu Arg Thr Ala Thr Ala Gly Arg Leu Leu Tyr
      50                  55                  60                
 Asp Met Phe Val Asn Phe Pro Asp Gln Pro Val Val Trp Arg Glu Ile
  65                  70                  75                  80
 Ser Ile Ile Thr Ser Ala Leu Arg Asn Asp Ser Gln Asp Lys Gln Thr
                  85                  90                  95    
 Gln Phe Leu Arg Ser Leu Phe Glu Thr Leu Pro Gly Arg Val Gln Cys
             100                 105                 110        
 Glu Met Leu Leu Lys Val Thr Glu Gln Cys Phe Asn Thr Leu Glu Arg
         115                 120                 125            
 Ser Glu Met Leu Leu Leu Leu Leu Arg Arg Phe Pro Glu Thr Val Val
     130                 135                 140                
 Gln His Gly Val Gly Leu Gly Glu Ala Leu Leu Glu Ala Glu Thr Ile
 145                 150                 155                 160
 Glu Glu Gln Glu Ser Pro Val Asn Cys Phe Arg Lys Leu Phe Val Cys
                 165                 170                 175    
 Asp Val Leu Pro Leu Ile Ile Asn Asn His Asp Val Arg Leu Pro Ala
             180                 185                 190        
 Asn Leu Leu Tyr Lys Tyr Leu Asn Lys Ala Ala Glu Phe Tyr Ile Asn
         195                 200                 205            
 Tyr Val Thr Arg Ser Thr Gln Ile Glu Asn Gln His Gln Gly Ala Gln
     210                 215                 220                
 Asp Thr Ser Asp Leu Met Ser Pro Ser Lys Arg Ser Ser Gln Lys Tyr
 225                 230                 235                 240
 Ile Ile Glu Gly Leu Thr Glu Lys Ser Ser Gln Ile Val Asp Pro Trp
                 245                 250                 255    
 Glu Arg Leu Phe Lys Ile Leu Asn Val Val Gly Met Arg Cys Glu Trp
             260                 265                 270        
 Gln Met Asp Lys Gly Arg Arg Ser Tyr Gly Asp Ile Leu His Arg Met
         275                 280                 285            
 Lys Asp Leu Cys Arg Tyr Met Asn Asn Phe Asp Ser Glu Ala His Ala
     290                 295                 300                
 Lys Tyr Lys Asn Gln Val Val Tyr Ser Thr Met Leu Val Phe Phe Lys
 305                 310                 315                 320
 Asn Ala Phe Gln Tyr Val Asn Ser Ile Gln Pro Ser Leu Phe Gln Gly
                 325                 330                 335    
 Pro Asn Ala Pro Ser Gln Val Pro Leu Val Leu Leu Glu Asp Val Ser
             340                 345                 350        
 Asn Val Tyr Gly Asp Val Glu Ile Asp Arg Asn Lys His Ile His Lys
         355                 360                 365            
 Lys Arg Lys Leu Ala Glu Gly Arg Glu Lys Thr Met Ser Ser Asp Asp
     370                 375                 380                
 Glu Asp Cys Ser Ala Lys Gly Arg Asn Arg His Ile Val Val Asn Lys
 385                 390                 395                 400
 Ala Glu Leu Ala Asn Ser Thr Glu Val Leu Glu Ser Phe Lys Leu Ala
                 405                 410                 415    
 Arg Glu Ser Trp Glu Leu Leu Tyr Ser Leu Glu Phe Leu Asp Lys Glu
             420                 425                 430        
 Phe Thr Arg Ile Cys Leu Ala Trp Lys Thr Asp Thr Trp Leu Trp Leu
         435                 440                 445            
 Arg Ile Phe Leu Thr Asp Met Ile Ile Tyr Gln Gly Gln Tyr Lys Lys
     450                 455                 460                
 Ala Ile Ala Ser Leu His His Leu Ala Ala Leu Gln Gly Ser Ile Ser
 465                 470                 475                 480
 Gln Pro Gln Ile Thr Gly Gln Gly Thr Leu Glu His Gln Arg Ala Leu
                 485                 490                 495    
 Ile Gln Leu Ala Thr Cys His Phe Ala Leu Gly Glu Tyr Arg Met Thr
             500                 505                 510        
 Cys Glu Lys Val Leu Asp Leu Met Cys Tyr Met Val Leu Pro Ile Gln
         515                 520                 525            
 Asp Gly Gly Lys Ser Gln Glu Glu Pro Ser Lys Val Lys Pro Lys Phe
     530                 535                 540                
 Arg Lys Gly Ser Asp Leu Lys Leu Leu Pro Cys Thr Ser Lys Ala Ile
 545                 550                 555                 560
 Met Pro Tyr Cys Leu His Leu Met Leu Ala Cys Phe Lys Leu Arg Ala
                 565                 570                 575    
 Phe Thr Asp Asn Arg Asp Asp Met Ala Leu Gly His Val Ile Val Leu
             580                 585                 590        
 Leu Gln Gln Glu Trp Pro Arg Gly Glu Asn Leu Phe Leu Lys Ala Val
         595                 600                 605            
 Asn Lys Ile Cys Gln Gln Gly Asn Phe Gln Tyr Glu Asn Phe Phe Asn
     610                 615                 620                
 Tyr Val Thr Asn Ile Asp Met Leu Glu Glu Phe Ala Tyr Leu Arg Thr
 625                 630                 635                 640
 Gln Glu Gly Gly Lys Ile His Leu Glu Leu Leu Pro Asn Gln Gly Met
                 645                 650                 655    
 Leu Ile Lys His His Thr Val Thr Arg Gly Ile Thr Lys Gly Val Lys
             660                 665                 670        
 Glu Asp Phe Arg Leu Ala Met Glu Arg Gln Val Ser Arg Cys Gly Glu
         675                 680                 685            
 Asn Leu Met Val Val Leu His Arg Phe Cys Ile Asn Glu Lys Ile Leu
     690                 695                 700                
 Leu Leu Gln Thr Leu Thr
 705                 710



      <210> 358
      <211> 737
      <212> PRT
      <213> Homo sapiens


      <400> 358
 Met Ser Ala Gln Gly Asp Cys Glu Phe Leu Val Gln Arg Ala Arg Glu
   1               5                  10                  15    
 Leu Val Pro Gln Asp Leu Trp Ala Ala Lys Ala Trp Leu Ile Thr Ala
              20                  25                  30        
 Arg Ser Leu Tyr Pro Ala Asp Phe Asn Ile Gln Tyr Glu Met Tyr Thr
          35                  40                  45            
 Ile Glu Arg Asn Ala Glu Arg Thr Ala Thr Ala Gly Arg Leu Leu Tyr
      50                  55                  60                
 Asp Met Phe Val Asn Phe Pro Asp Gln Pro Val Val Trp Arg Glu Ile
  65                  70                  75                  80
 Ser Ile Ile Thr Ser Ala Leu Arg Asn Asp Ser Gln Asp Lys Gln Thr
                  85                  90                  95    
 Gln Phe Leu Arg Ser Leu Phe Glu Thr Leu Pro Gly Arg Val Gln Cys
             100                 105                 110        
 Glu Met Leu Leu Lys Val Thr Glu Gln Cys Phe Asn Thr Leu Glu Arg
         115                 120                 125            
 Ser Glu Met Leu Leu Leu Leu Leu Arg Arg Phe Pro Glu Thr Val Val
     130                 135                 140                
 Gln His Gly Val Gly Leu Gly Glu Ala Leu Leu Glu Ala Glu Thr Ile
 145                 150                 155                 160
 Glu Glu Gln Glu Ser Pro Val Asn Cys Phe Arg Lys Leu Phe Val Cys
                 165                 170                 175    
 Asp Val Leu Pro Leu Ile Ile Asn Asn His Asp Val Arg Leu Pro Ala
             180                 185                 190        
 Asn Leu Leu Tyr Lys Tyr Leu Asn Lys Ala Ala Glu Phe Tyr Ile Asn
         195                 200                 205            
 Tyr Val Thr Arg Ser Thr Gln Ile Glu Asn Gln His Gln Gly Ala Gln
     210                 215                 220                
 Asp Thr Ser Asp Leu Met Ser Pro Ser Lys Arg Ser Ser Gln Lys Tyr
 225                 230                 235                 240
 Ile Ile Glu Gly Leu Thr Glu Lys Ser Ser Gln Ile Val Asp Pro Trp
                 245                 250                 255    
 Glu Arg Leu Phe Lys Ile Leu Asn Val Val Gly Met Arg Cys Glu Trp
             260                 265                 270        
 Gln Met Asp Lys Gly Arg Arg Ser Tyr Gly Asp Ile Leu His Arg Met
         275                 280                 285            
 Lys Asp Leu Cys Arg Tyr Met Asn Asn Phe Asp Ser Glu Ala His Ala
     290                 295                 300                
 Lys Tyr Lys Asn Gln Val Val Tyr Ser Thr Met Leu Val Phe Phe Lys
 305                 310                 315                 320
 Asn Ala Phe Gln Tyr Val Asn Ser Ile Gln Pro Ser Leu Phe Gln Gly
                 325                 330                 335    
 Pro Asn Ala Pro Ser Gln Val Pro Leu Val Leu Leu Glu Asp Val Ser
             340                 345                 350        
 Asn Val Tyr Gly Asp Val Glu Ile Asp Arg Asn Lys His Ile His Lys
         355                 360                 365            
 Lys Arg Lys Leu Ala Glu Gly Arg Glu Lys Thr Met Ser Ser Asp Asp
     370                 375                 380                
 Glu Asp Cys Ser Ala Lys Gly Arg Asn Arg His Ile Val Val Asn Lys
 385                 390                 395                 400
 Ala Glu Leu Ala Asn Ser Thr Glu Val Leu Glu Ser Phe Lys Leu Ala
                 405                 410                 415    
 Arg Glu Ser Trp Glu Leu Leu Tyr Ser Leu Glu Phe Leu Asp Lys Glu
             420                 425                 430        
 Phe Thr Arg Ile Cys Leu Ala Trp Lys Thr Asp Thr Trp Leu Trp Leu
         435                 440                 445            
 Arg Ile Phe Leu Thr Asp Met Ile Ile Tyr Gln Gly Gln Tyr Lys Lys
     450                 455                 460                
 Ala Ile Ala Ser Leu His His Leu Ala Ala Leu Gln Gly Ser Ile Ser
 465                 470                 475                 480
 Gln Pro Gln Ile Thr Gly Gln Gly Thr Leu Glu His Gln Arg Ala Leu
                 485                 490                 495    
 Ile Gln Leu Ala Thr Cys His Phe Ala Leu Gly Glu Tyr Arg Met Thr
             500                 505                 510        
 Cys Glu Lys Val Leu Asp Leu Met Cys Tyr Met Val Leu Pro Ile Gln
         515                 520                 525            
 Asp Gly Gly Lys Ser Gln Glu Glu Pro Ser Lys Val Lys Pro Lys Phe
     530                 535                 540                
 Arg Lys Gly Ser Asp Leu Lys Leu Leu Pro Cys Thr Ser Lys Ala Ile
 545                 550                 555                 560
 Met Pro Tyr Cys Leu His Leu Met Leu Ala Cys Phe Lys Leu Arg Ala
                 565                 570                 575    
 Phe Thr Asp Asn Arg Asp Asp Met Ala Leu Gly His Val Ile Val Leu
             580                 585                 590        
 Leu Gln Gln Glu Trp Pro Arg Gly Glu Asn Leu Phe Leu Lys Ala Val
         595                 600                 605            
 Asn Lys Ile Cys Gln Gln Gly Asn Phe Gln Tyr Glu Asn Phe Phe Asn
     610                 615                 620                
 Tyr Val Thr Asn Ile Asp Met Leu Glu Glu Phe Ala Tyr Leu Arg Thr
 625                 630                 635                 640
 Gln Glu Gly Gly Lys Ile His Leu Glu Leu Leu Pro Asn Gln Gly Met
                 645                 650                 655    
 Leu Ile Lys Pro Ser Ser Pro Pro Met Gly Leu Leu Gln Gln Glu Phe
             660                 665                 670        
 Leu Pro Val Leu Gln Pro Ser Ile Gln Thr Ala Asp Arg His His Thr
         675                 680                 685            
 Val Thr Arg Gly Ile Thr Lys Gly Val Lys Glu Asp Phe Arg Leu Ala
     690                 695                 700                
 Met Glu Arg Gln Val Ser Arg Cys Gly Glu Asn Leu Met Val Val Leu
 705                 710                 715                 720
 His Arg Phe Cys Ile Asn Glu Lys Ile Leu Leu Leu Gln Thr Leu Thr
                 725                 730                 735    





      <210> 359
      <211> 1713
      <212> PRT
      <213> Homo sapiens


      <400> 359
 Met Ala Ser Gly Ser Arg Trp Arg Pro Thr Pro Pro Pro Leu Leu Leu
   1               5                  10                  15    
 Leu Leu Leu Leu Ala Leu Ala Ala Arg Ala Asp Gly Leu Glu Phe Gly
              20                  25                  30        
 Gly Gly Pro Gly Gln Trp Ala Arg Tyr Ala Arg Trp Ala Gly Ala Ala
          35                  40                  45            
 Ser Ser Gly Glu Leu Ser Phe Ser Leu Arg Thr Asn Ala Thr Arg Ala
      50                  55                  60                
 Leu Leu Leu Tyr Leu Asp Asp Gly Gly Asp Cys Asp Phe Leu Glu Leu
  65                  70                  75                  80
 Leu Leu Val Asp Gly Arg Leu Arg Leu Arg Phe Thr Leu Ser Cys Ala
                  85                  90                  95    
 Glu Pro Ala Thr Leu Gln Leu Asp Thr Pro Val Ala Asp Asp Arg Trp
             100                 105                 110        
 His Met Val Leu Leu Thr Arg Asp Ala Arg Arg Thr Ala Leu Ala Val
         115                 120                 125            
 Asp Gly Glu Ala Arg Ala Ala Glu Val Arg Ser Lys Arg Arg Glu Met
     130                 135                 140                
 Gln Val Ala Ser Asp Leu Phe Val Gly Gly Ile Pro Pro Asp Val Arg
 145                 150                 155                 160
 Leu Ser Ala Leu Thr Leu Ser Thr Val Lys Tyr Glu Pro Pro Phe Arg
                 165                 170                 175    
 Gly Leu Leu Ala Asn Leu Lys Leu Gly Glu Arg Pro Pro Ala Leu Leu
             180                 185                 190        
 Gly Ser Gln Gly Leu Arg Gly Ala Thr Ala Asp Pro Leu Cys Ala Pro
         195                 200                 205            
 Ala Arg Asn Pro Cys Ala Asn Gly Gly Leu Cys Thr Val Leu Ala Pro
     210                 215                 220                
 Gly Glu Val Gly Cys Asp Cys Ser His Thr Gly Phe Gly Gly Lys Phe
 225                 230                 235                 240
 Cys Ser Glu Glu Glu His Pro Met Glu Gly Pro Ala His Leu Thr Leu
                 245                 250                 255    
 Asn Ser Glu Val Gly Ser Leu Leu Phe Ser Glu Gly Gly Ala Gly Arg
             260                 265                 270        
 Gly Gly Ala Gly Asp Val His Gln Pro Thr Lys Gly Lys Glu Glu Phe
         275                 280                 285            
 Val Ala Thr Phe Lys Gly Asn Glu Phe Phe Cys Tyr Asp Leu Ser His
     290                 295                 300                
 Asn Pro Ile Gln Ser Ser Thr Asp Glu Ile Thr Leu Ala Phe Arg Thr
 305                 310                 315                 320
 Leu Gln Arg Asn Gly Leu Met Leu His Thr Gly Lys Ser Ala Asp Tyr
                 325                 330                 335    
 Val Asn Leu Ser Leu Lys Ser Gly Ala Val Trp Leu Val Ile Asn Leu
             340                 345                 350        
 Gly Ser Gly Ala Phe Glu Ala Leu Val Glu Pro Val Asn Gly Lys Phe
         355                 360                 365            
 Asn Asp Asn Ala Trp His Asp Val Arg Val Thr Arg Asn Leu Arg Gln
     370                 375                 380                
 His Ala Gly Ile Gly His Ala Met Val Asn Lys Leu His Tyr Leu Val
 385                 390                 395                 400
 Thr Ile Ser Val Asp Gly Ile Leu Thr Thr Thr Gly Tyr Thr Gln Glu
                 405                 410                 415    
 Asp Tyr Thr Met Leu Gly Ser Asp Asp Phe Phe Tyr Ile Gly Gly Ser
             420                 425                 430        
 Pro Asn Thr Ala Asp Leu Pro Gly Ser Pro Val Ser Asn Asn Phe Met
         435                 440                 445            
 Gly Cys Leu Lys Asp Val Val Tyr Lys Asn Asn Asp Phe Lys Leu Glu
     450                 455                 460                
 Leu Ser Arg Leu Ala Lys Glu Gly Asp Pro Lys Met Lys Leu Gln Gly
 465                 470                 475                 480
 Asp Leu Ser Phe Arg Cys Glu Asp Val Ala Ala Leu Asp Pro Val Thr
                 485                 490                 495    
 Phe Glu Ser Pro Glu Ala Phe Val Ala Leu Pro Arg Trp Ser Ala Lys
             500                 505                 510        
 Arg Thr Gly Ser Ile Ser Leu Asp Phe Arg Thr Thr Glu Pro Asn Gly
         515                 520                 525            
 Leu Leu Leu Phe Ser Gln Gly Arg Arg Ala Gly Gly Gly Ala Gly Ser
     530                 535                 540                
 His Ser Ser Ala Gln Arg Ala Asp Tyr Phe Ala Met Glu Leu Leu Asp
 545                 550                 555                 560
 Gly His Leu Tyr Leu Leu Leu Asp Met Gly Ser Gly Gly Ile Lys Leu
                 565                 570                 575    
 Arg Ala Ser Ser Arg Lys Val Asn Asp Gly Glu Trp Cys His Val Asp
             580                 585                 590        
 Phe Gln Arg Asp Gly Arg Lys Gly Ser Ile Ser Val Asn Ser Arg Ser
         595                 600                 605            
 Thr Pro Phe Leu Ala Thr Gly Asp Ser Glu Ile Leu Asp Leu Glu Ser
     610                 615                 620                
 Glu Leu Tyr Leu Gly Gly Leu Pro Glu Gly Gly Arg Val Asp Leu Pro
 625                 630                 635                 640
 Leu Pro Pro Glu Val Trp Thr Ala Ala Leu Arg Ala Gly Tyr Val Gly
                 645                 650                 655    
 Cys Val Arg Asp Leu Phe Ile Asp Gly Arg Ser Arg Asp Leu Arg Gly
             660                 665                 670        
 Leu Ala Glu Ala Gln Gly Ala Val Gly Val Ala Pro Phe Cys Ser Arg
         675                 680                 685            
 Glu Thr Leu Lys Gln Cys Ala Ser Ala Pro Cys Arg Asn Gly Gly Val
     690                 695                 700                
 Cys Arg Glu Gly Trp Asn Arg Phe Ile Cys Asp Cys Ile Gly Thr Gly
 705                 710                 715                 720
 Phe Leu Gly Arg Val Cys Glu Arg Glu Ala Thr Val Leu Ser Tyr Asp
                 725                 730                 735    
 Gly Ser Met Tyr Met Lys Ile Met Leu Pro Asn Ala Met His Thr Glu
             740                 745                 750        
 Ala Glu Asp Val Ser Leu Arg Phe Met Ser Gln Arg Ala Tyr Gly Leu
         755                 760                 765            
 Met Met Ala Thr Thr Ser Arg Glu Ser Ala Asp Thr Leu Arg Leu Glu
     770                 775                 780                
 Leu Asp Gly Gly Gln Met Lys Leu Thr Val Asn Leu Asp Cys Leu Arg
 785                 790                 795                 800
 Val Gly Cys Ala Pro Ser Lys Gly Pro Glu Thr Leu Phe Ala Gly His
                 805                 810                 815    
 Lys Leu Asn Asp Asn Glu Trp His Thr Val Arg Val Val Arg Arg Gly
             820                 825                 830        
 Lys Ser Leu Gln Leu Ser Val Asp Asn Val Thr Val Glu Gly Gln Met
         835                 840                 845            
 Ala Gly Ala His Met Arg Leu Glu Phe His Asn Ile Glu Thr Gly Ile
     850                 855                 860                
 Met Thr Glu Arg Arg Phe Ile Ser Val Val Pro Ser Asn Phe Ile Gly
 865                 870                 875                 880
 His Leu Ser Gly Leu Val Phe Asn Gly Gln Pro Tyr Met Asp Gln Cys
                 885                 890                 895    
 Lys Asp Gly Asp Ile Thr Tyr Cys Glu Leu Asn Ala Arg Phe Gly Leu
             900                 905                 910        
 Arg Ala Ile Val Ala Asp Pro Val Thr Phe Lys Ser Arg Ser Ser Tyr
         915                 920                 925            
 Leu Ala Leu Ala Thr Leu Gln Ala Tyr Ala Ser Met His Leu Phe Phe
     930                 935                 940                
 Gln Phe Lys Thr Thr Ala Pro Asp Gly Leu Leu Leu Phe Asn Ser Gly
 945                 950                 955                 960
 Asn Gly Asn Asp Phe Ile Val Ile Glu Leu Val Lys Gly Tyr Ile His
                 965                 970                 975    
 Tyr Val Phe Asp Leu Gly Asn Gly Pro Ser Leu Met Lys Gly Asn Ser
             980                 985                 990        
 Asp Lys Pro Val Asn Asp Asn Gln Trp His Asn Val Val Val Ser Arg
         995                1000                1005            
 Asp Pro Gly Asn Val His Thr Leu Lys Ile Asp Ser Arg Thr Val Thr
    1010                1015                1020                
 Gln His Ser Asn Gly Ala Arg Asn Leu Asp Leu Lys Gly Glu Leu Tyr
1025                1030                1035                1040
 Ile Gly Gly Leu Ser Lys Asn Met Phe Ser Asn Leu Pro Lys Leu Val
                1045                1050                1055    
 Ala Ser Arg Asp Gly Phe Gln Gly Cys Leu Ala Ser Val Asp Leu Asn
            1060                1065                1070        
 Gly Arg Leu Pro Asp Leu Ile Ala Asp Ala Leu His Arg Ile Gly Gln
        1075                1080                1085            
 Val Glu Arg Gly Cys Asp Gly Pro Ser Thr Thr Cys Thr Glu Glu Ser
    1090                1095                1100                
 Cys Ala Asn Gln Gly Val Cys Leu Gln Gln Trp Asp Gly Phe Thr Cys
1105                1110                1115                1120
 Asp Cys Thr Met Thr Ser Tyr Gly Gly Pro Val Cys Asn Asp Pro Gly
                1125                1130                1135    
 Thr Thr Tyr Ile Phe Gly Lys Gly Gly Ala Leu Ile Thr Tyr Thr Trp
            1140                1145                1150        
 Pro Pro Asn Asp Arg Pro Ser Thr Arg Met Asp Arg Leu Ala Val Gly
        1155                1160                1165            
 Phe Ser Thr His Gln Arg Ser Ala Val Leu Val Arg Val Asp Ser Ala
    1170                1175                1180                
 Ser Gly Leu Gly Asp Tyr Leu Gln Leu His Ile Asp Gln Gly Thr Val
1185                1190                1195                1200
 Gly Val Ile Phe Asn Val Gly Thr Asp Asp Ile Thr Ile Asp Glu Pro
                1205                1210                1215    
 Asn Ala Ile Val Ser Asp Gly Lys Tyr His Val Val Arg Phe Thr Arg
            1220                1225                1230        
 Ser Gly Gly Asn Ala Thr Leu Gln Val Asp Ser Trp Pro Val Asn Glu
        1235                1240                1245            
 Arg Tyr Pro Ala Gly Asn Phe Asp Asn Glu Arg Leu Ala Ile Ala Arg
    1250                1255                1260                
 Gln Arg Ile Pro Tyr Arg Leu Gly Arg Val Val Asp Glu Trp Leu Leu
1265                1270                1275                1280
 Asp Lys Gly Arg Gln Leu Thr Ile Phe Asn Ser Gln Ala Ala Ile Lys
                1285                1290                1295    
 Ile Gly Gly Arg Asp Gln Gly Arg Pro Phe Gln Gly Gln Val Ser Gly
            1300                1305                1310        
 Leu Tyr Tyr Asn Gly Leu Lys Val Leu Ala Leu Ala Ala Glu Ser Asp
        1315                1320                1325            
 Pro Asn Val Arg Thr Glu Gly His Leu Arg Leu Val Gly Glu Gly Pro
    1330                1335                1340                
 Ser Val Leu Leu Ser Ala Glu Thr Thr Ala Thr Thr Leu Leu Ala Asp
1345                1350                1355                1360
 Met Ala Thr Thr Ile Met Glu Thr Thr Thr Thr Met Ala Thr Thr Thr
                1365                1370                1375    
 Thr Arg Arg Gly Arg Ser Pro Thr Leu Arg Asp Ser Thr Thr Gln Asn
            1380                1385                1390        
 Thr Asp Asp Leu Leu Val Ala Ser Ala Glu Cys Pro Ser Asp Asp Glu
        1395                1400                1405            
 Asp Leu Glu Glu Cys Glu Pro Ser Thr Gly Gly Glu Leu Ile Leu Pro
    1410                1415                1420                
 Ile Ile Thr Glu Asp Ser Leu Asp Pro Pro Pro Val Ala Thr Arg Ser
1425                1430                1435                1440
 Pro Phe Val Pro Pro Pro Pro Thr Phe Tyr Pro Phe Leu Thr Gly Val
                1445                1450                1455    
 Gly Ala Thr Gln Asp Thr Leu Pro Pro Pro Ala Ala Arg Arg Pro Pro
            1460                1465                1470        
 Ser Gly Gly Pro Cys Gln Ala Glu Arg Asp Asp Ser Asp Cys Glu Glu
        1475                1480                1485            
 Pro Ile Glu Ala Ser Gly Phe Ala Ser Gly Glu Val Phe Asp Ser Ser
    1490                1495                1500                
 Leu Pro Pro Thr Asp Asp Glu Asp Phe Tyr Thr Thr Phe Pro Leu Val
1505                1510                1515                1520
 Thr Asp Arg Thr Thr Leu Leu Ser Pro Arg Lys Pro Ala Pro Arg Pro
                1525                1530                1535    
 Asn Leu Arg Thr Asp Gly Ala Thr Gly Ala Pro Gly Val Leu Phe Ala
            1540                1545                1550        
 Pro Ser Ala Pro Ala Pro Asn Leu Pro Ala Gly Lys Met Asn His Arg
        1555                1560                1565            
 Asp Pro Leu Gln Pro Leu Leu Glu Asn Pro Pro Leu Gly Pro Gly Ala
    1570                1575                1580                
 Pro Thr Ser Phe Glu Pro Arg Arg Pro Pro Pro Leu Arg Pro Gly Val
1585                1590                1595                1600
 Thr Ser Ala Pro Gly Phe Pro His Leu Pro Thr Ala Asn Pro Thr Gly
                1605                1610                1615    
 Pro Gly Glu Arg Gly Pro Pro Gly Ala Val Glu Val Ile Arg Glu Ser
            1620                1625                1630        
 Ser Ser Thr Thr Gly Met Val Val Gly Ile Val Ala Ala Ala Ala Leu
        1635                1640                1645            
 Cys Ile Leu Ile Leu Leu Tyr Ala Met Tyr Lys Tyr Arg Asn Arg Asp
    1650                1655                1660                
 Glu Gly Ser Tyr Gln Val Asp Gln Ser Arg Asn Tyr Ile Ser Asn Ser
1665                1670                1675                1680
 Ala Gln Ser Asn Gly Ala Val Val Lys Glu Lys Ala Pro Ala Ala Pro
                1685                1690                1695    
 Lys Thr Pro Ser Lys Ala Lys Lys Asn Lys Asp Lys Glu Tyr Tyr Val
            1700                1705                1710        





      <210> 360
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 360
 Met Ile Arg Phe Ile Leu Ile Gln Asn Arg Ala Gly Lys Thr Arg Leu
   1               5                  10                  15    
 Ala Lys Trp Tyr Met Gln Phe Asp Asp Asp Glu Lys Gln Lys Leu Ile
              20                  25                  30        
 Glu Glu Val His Ala Val Val Thr Val Arg Asp Ala Lys His Thr Asn
          35                  40                  45            
 Phe Val Glu Val Leu Ala Ser Ser Val Ala Asp Ser Leu Ser Val Leu
      50                  55                  60                
 Gln Phe Arg Asn Phe Lys Ile Ile Tyr Arg Arg Tyr Ala Gly Leu Tyr
  65                  70                  75                  80
 Phe Cys Ile Cys Val Asp Val Asn Asp Asn Asn Leu Ala Tyr Leu Glu
                  85                  90                  95    
 Ala Ile His Asn Phe Val Glu Val Leu Asn Glu Tyr Phe His Asn Val
             100                 105                 110        
 Cys Glu Leu Asp Leu Val Phe Asn Phe Tyr Lys Val Tyr Thr Val Val
         115                 120                 125            
 Asp Glu Met Phe Leu Ala Gly Glu Ile Arg Glu Thr Ser Gln Thr Lys
     130                 135                 140                
 Val Leu Lys Gln Leu Leu Met Leu Gln Ser Leu Glu
 145                 150                 155    



      <210> 361
      <211> 261
      <212> PRT
      <213> Homo sapiens


      <400> 361
 Met Asn Ser Ala Ala Gly Phe Ser His Leu Asp Arg Arg Glu Arg Val
   1               5                  10                  15    
 Leu Lys Leu Gly Glu Ser Phe Glu Lys Gln Pro Arg Cys Ala Phe His
              20                  25                  30        
 Thr Val Arg Tyr Asp Phe Lys Pro Ala Ser Ile Asp Thr Ser Ser Glu
          35                  40                  45            
 Gly Tyr Leu Glu Val Gly Glu Gly Glu Gln Val Thr Ile Thr Leu Pro
      50                  55                  60                
 Asn Ile Glu Gly Ser Thr Pro Pro Val Thr Val Phe Lys Gly Ser Lys
  65                  70                  75                  80
 Lys Pro Tyr Leu Lys Glu Cys Ile Leu Ile Ile Asn His Asp Thr Gly
                  85                  90                  95    
 Glu Cys Arg Leu Glu Lys Leu Ser Ser Asn Ile Thr Val Lys Lys Thr
             100                 105                 110        
 Arg Val Glu Gly Ser Ser Lys Ile Gln Tyr Arg Lys Glu Gln Gln Gln
         115                 120                 125            
 Gln Gln Met Trp Asn Ser Ala Arg Thr Pro Asn Leu Val Lys His Ser
     130                 135                 140                
 Pro Ser Glu Asp Lys Met Ser Pro Ala Ser Pro Ile Asp Asp Ile Glu
 145                 150                 155                 160
 Arg Glu Leu Lys Ala Glu Ala Ser Leu Met Asp Gln Met Ser Ser Cys
                 165                 170                 175    
 Asp Ser Ser Ser Asp Ser Lys Ser Ser Ser Ser Ser Ser Ser Glu Asp
             180                 185                 190        
 Ser Ser Ser Asp Ser Glu Asp Glu Asp Cys Lys Ser Ser Thr Ser Asp
         195                 200                 205            
 Thr Gly Asn Cys Val Ser Gly His Pro Thr Met Thr Gln Tyr Arg Ile
     210                 215                 220                
 Pro Asp Ile Asp Ala Ser His Asn Arg Phe Arg Asp Asn Ser Gly Leu
 225                 230                 235                 240
 Leu Met Asn Thr Leu Arg Asn Asp Leu Gln Leu Ser Glu Ser Gly Ser
                 245                 250                 255    
 Asp Ser Asp Asp
             260



      <210> 362
      <211> 406
      <212> PRT
      <213> Homo sapiens


      <400> 362
 Met Ala Ser Pro Arg Thr Arg Lys Val Leu Lys Glu Val Arg Val Gln
   1               5                  10                  15    
 Asp Glu Asn Asn Val Cys Phe Glu Cys Gly Ala Phe Asn Pro Gln Trp
              20                  25                  30        
 Val Ser Val Thr Tyr Gly Ile Trp Ile Cys Leu Glu Cys Ser Gly Arg
          35                  40                  45            
 His Arg Gly Leu Gly Val His Leu Ser Phe Val Arg Ser Val Thr Met
      50                  55                  60                
 Asp Lys Trp Lys Asp Ile Glu Leu Glu Lys Met Lys Ala Gly Gly Asn
  65                  70                  75                  80
 Ala Lys Phe Arg Glu Phe Leu Glu Ser Gln Glu Asp Tyr Asp Pro Cys
                  85                  90                  95    
 Trp Ser Leu Gln Glu Lys Tyr Asn Ser Arg Ala Ala Ala Leu Phe Arg
             100                 105                 110        
 Asp Lys Val Val Ala Leu Ala Glu Gly Arg Glu Trp Ser Leu Glu Ser
         115                 120                 125            
 Ser Pro Ala Gln Asn Trp Thr Pro Pro Gln Pro Arg Thr Leu Pro Ser
     130                 135                 140                
 Met Val His Arg Val Ser Gly Gln Pro Gln Ser Val Thr Ala Ser Ser
 145                 150                 155                 160
 Asp Lys Ala Phe Glu Asp Trp Leu Asn Asp Asp Leu Gly Ser Tyr Gln
                 165                 170                 175    
 Gly Ala Gln Gly Asn Arg Tyr Val Gly Phe Gly Asn Thr Pro Pro Pro
             180                 185                 190        
 Gln Lys Lys Glu Asp Asp Phe Leu Asn Asn Ala Met Ser Ser Leu Tyr
         195                 200                 205            
 Ser Gly Trp Ser Ser Phe Thr Thr Gly Ala Ser Arg Phe Ala Ser Ala
     210                 215                 220                
 Ala Lys Glu Gly Ala Thr Lys Phe Gly Ser Gln Ala Ser Gln Lys Ala
 225                 230                 235                 240
 Ser Glu Leu Gly His Ser Leu Asn Glu Asn Val Leu Lys Pro Ala Gln
                 245                 250                 255    
 Glu Lys Val Lys Glu Gly Lys Ile Phe Asp Asp Val Ser Ser Gly Val
             260                 265                 270        
 Ser Gln Leu Ala Ser Lys Val Gln Gly Val Gly Ser Lys Gly Trp Arg
         275                 280                 285            
 Asp Val Thr Thr Phe Phe Ser Gly Lys Ala Glu Gly Pro Leu Asp Ser
     290                 295                 300                
 Pro Ser Glu Gly His Ser Tyr Gln Asn Ser Gly Leu Asp His Phe Gln
 305                 310                 315                 320
 Asn Ser Asn Ile Asp Gln Ser Phe Trp Glu Thr Phe Gly Ser Ala Glu
                 325                 330                 335    
 Pro Thr Lys Thr Arg Lys Ser Pro Ser Ser Asp Ser Trp Thr Cys Ala
             340                 345                 350        
 Asp Thr Ser Thr Glu Arg Arg Ser Ser Asp Ser Trp Glu Val Trp Gly
         355                 360                 365            
 Ser Ala Ser Thr Asn Arg Asn Ser Asn Ser Asp Gly Gly Glu Gly Gly
     370                 375                 380                
 Glu Gly Thr Lys Lys Ala Val Pro Pro Ala Val Pro Thr Asp Asp Gly
 385                 390                 395                 400
 Trp Asp Asn Gln Asn Trp
                 405    



      <210> 363
      <211> 941
      <212> PRT
      <213> Homo sapiens


      <400> 363
 Met Gly Ser Gly Pro Ile Asp Pro Lys Glu Leu Leu Lys Gly Leu Asp
   1               5                  10                  15    
 Ser Phe Leu Asn Arg Asp Gly Glu Val Lys Ser Val Asp Gly Ile Ser
              20                  25                  30        
 Lys Ile Phe Ser Leu Met Lys Glu Ala Arg Lys Met Val Ser Arg Cys
          35                  40                  45            
 Thr Tyr Leu Asn Ile Leu Leu Gln Thr Arg Ser Pro Glu Ile Leu Val
      50                  55                  60                
 Lys Phe Ile Asp Val Gly Gly Tyr Lys Leu Leu Asn Asn Trp Leu Thr
  65                  70                  75                  80
 Tyr Ser Lys Thr Thr Asn Asn Ile Pro Leu Leu Gln Gln Ile Leu Leu
                  85                  90                  95    
 Thr Leu Gln His Leu Pro Leu Thr Val Asp His Leu Lys Gln Asn Asn
             100                 105                 110        
 Thr Ala Lys Leu Val Lys Gln Leu Ser Lys Ser Ser Glu Asp Glu Glu
         115                 120                 125            
 Leu Arg Lys Leu Ala Ser Val Leu Val Ser Asp Trp Met Ala Val Ile
     130                 135                 140                
 Arg Ser Gln Ser Ser Thr Gln Pro Ala Glu Lys Asp Lys Lys Lys Arg
 145                 150                 155                 160
 Lys Asp Glu Gly Lys Ser Arg Thr Thr Leu Pro Glu Arg Pro Leu Thr
                 165                 170                 175    
 Glu Val Lys Ala Glu Thr Arg Ala Glu Glu Ala Pro Glu Lys Lys Arg
             180                 185                 190        
 Glu Lys Pro Lys Ser Leu Arg Thr Thr Ala Pro Ser His Ala Lys Phe
         195                 200                 205            
 Arg Ser Thr Gly Leu Glu Leu Glu Thr Pro Ser Leu Val Pro Val Lys
     210                 215                 220                
 Lys Asn Ala Ser Thr Val Val Val Ser Asp Lys Tyr Asn Leu Lys Pro
 225                 230                 235                 240
 Ile Pro Leu Lys Arg Gln Ser Asn Val Ala Ala Pro Gly Asp Ala Thr
                 245                 250                 255    
 Pro Pro Ala Glu Lys Lys Tyr Lys Pro Leu Asn Thr Thr Pro Asn Ala
             260                 265                 270        
 Thr Lys Glu Ile Lys Val Lys Ile Ile Pro Pro Gln Pro Met Glu Gly
         275                 280                 285            
 Leu Gly Phe Leu Asp Ala Leu Asn Ser Ala Pro Val Pro Gly Ile Lys
     290                 295                 300                
 Ile Lys Lys Lys Lys Lys Val Leu Ser Pro Thr Ala Ala Lys Pro Ser
 305                 310                 315                 320
 Pro Phe Glu Gly Lys Thr Ser Thr Glu Pro Ser Thr Ala Lys Pro Ser
                 325                 330                 335    
 Ser Pro Glu Pro Ala Pro Pro Ser Glu Ala Met Asp Ala Asp Arg Pro
             340                 345                 350        
 Gly Thr Pro Val Pro Pro Val Glu Val Pro Glu Leu Met Asp Thr Ala
         355                 360                 365            
 Ser Leu Glu Pro Gly Ala Leu Asp Ala Lys Pro Val Glu Ser Pro Gly
     370                 375                 380                
 Asp Pro Asn Gln Leu Thr Arg Lys Gly Arg Lys Arg Lys Ser Val Thr
 385                 390                 395                 400
 Trp Pro Glu Glu Gly Lys Leu Arg Glu Tyr Phe Tyr Phe Glu Leu Asp
                 405                 410                 415    
 Glu Thr Glu Arg Val Asn Val Asn Lys Ile Lys Asp Phe Gly Glu Ala
             420                 425                 430        
 Ala Lys Arg Glu Ile Leu Ser Asp Arg His Ala Phe Glu Thr Ala Arg
         435                 440                 445            
 Arg Leu Ser His Asp Asn Met Glu Glu Lys Val Pro Trp Val Cys Pro
     450                 455                 460                
 Arg Pro Leu Val Leu Pro Ser Pro Leu Val Thr Pro Gly Ser Asn Ser
 465                 470                 475                 480
 Gln Glu Arg Tyr Ile Gln Ala Glu Arg Glu Lys Gly Ile Leu Gln Glu
                 485                 490                 495    
 Leu Phe Leu Asn Lys Glu Ser Pro His Glu Pro Asp Pro Glu Pro Tyr
             500                 505                 510        
 Glu Pro Ile Pro Pro Lys Leu Ile Pro Leu Asp Glu Glu Cys Ser Met
         515                 520                 525            
 Asp Glu Thr Pro Tyr Val Glu Thr Leu Glu Pro Gly Gly Ser Gly Gly
     530                 535                 540                
 Ser Pro Asp Gly Ala Gly Gly Ser Lys Leu Pro Pro Val Leu Ala Asn
 545                 550                 555                 560
 Leu Met Gly Ser Met Gly Ala Gly Lys Gly Pro Gln Gly Pro Gly Gly
                 565                 570                 575    
 Gly Gly Ile Asn Val Gln Glu Ile Leu Thr Ser Ile Met Gly Ser Pro
             580                 585                 590        
 Asn Ser His Pro Ser Glu Glu Leu Leu Lys Gln Pro Asp Tyr Ser Asp
         595                 600                 605            
 Lys Ile Lys Gln Met Leu Val Pro His Gly Leu Leu Gly Pro Gly Pro
     610                 615                 620                
 Ile Ala Asn Gly Phe Pro Pro Gly Gly Pro Gly Gly Pro Lys Gly Met
 625                 630                 635                 640
 Gln His Phe Pro Pro Gly Pro Gly Gly Pro Met Pro Gly Pro His Gly
                 645                 650                 655    
 Gly Pro Gly Gly Pro Val Gly Pro Arg Leu Leu Gly Pro Pro Pro Pro
             660                 665                 670        
 Pro Arg Gly Gly Asp Pro Phe Trp Asp Gly Pro Gly Asp Pro Met Arg
         675                 680                 685            
 Gly Gly Pro Met Arg Gly Gly Pro Gly Pro Gly Pro Gly Pro Tyr His
     690                 695                 700                
 Arg Gly Arg Gly Gly Arg Gly Gly Asn Glu Pro Pro Pro Pro Pro Pro
 705                 710                 715                 720
 Pro Phe Arg Gly Ala Arg Gly Gly Arg Ser Gly Gly Gly Pro Pro Asn
                 725                 730                 735    
 Gly Arg Gly Gly Pro Gly Gly Gly Met Val Gly Gly Gly Gly His Arg
             740                 745                 750        
 Pro His Glu Gly Pro Gly Gly Gly Met Gly Asn Ser Ser Gly His Arg
         755                 760                 765            
 Pro His Glu Gly Pro Gly Gly Gly Met Gly Ser Gly His Arg Pro His
     770                 775                 780                
 Glu Gly Pro Gly Gly Ser Met Gly Gly Gly Gly Gly His Arg Pro His
 785                 790                 795                 800
 Glu Gly Pro Gly Gly Gly Ile Ser Gly Gly Ser Gly His Arg Pro His
                 805                 810                 815    
 Glu Gly Pro Gly Gly Gly Met Gly Ala Gly Gly Gly His Arg Pro His
             820                 825                 830        
 Glu Gly Pro Gly Gly Ser Met Gly Gly Ser Gly Gly His Arg Pro His
         835                 840                 845            
 Glu Gly Pro Gly His Gly Gly Pro His Gly His Arg Pro His Asp Val
     850                 855                 860                
 Pro Gly His Arg Gly His Asp His Arg Gly Pro Pro Pro His Glu His
 865                 870                 875                 880
 Arg Gly His Asp Gly Pro Gly His Gly Gly Gly Gly His Arg Gly His
                 885                 890                 895    
 Asp Gly Gly His Ser His Gly Gly Asp Met Ser Asn Arg Pro Val Cys
             900                 905                 910        
 Arg His Phe Met Met Lys Gly Asn Cys Arg Tyr Glu Asn Asn Cys Ala
         915                 920                 925            
 Phe Tyr His Pro Gly Val Asn Gly Pro Pro Leu Pro
     930                 935                 940



      <210> 364
      <211> 76
      <212> PRT
      <213> Homo sapiens


      <400> 364
 Met Phe Pro Phe Leu Cys Pro Cys Val Leu Ile Val Gln Phe Pro Pro
   1               5                  10                  15    
 Met Ser Glu Asn Met Trp Val Trp Phe Phe Cys Pro Cys Asp Ser Leu
              20                  25                  30        
 Leu Arg Met Met Val Ser Ser Phe Ile His Val Pro Ala Lys Asp Met
          35                  40                  45            
 Asn Ser Pro Phe Phe Met Glu Tyr Tyr Thr Ala Ile Lys Arg Asn Asp
      50                  55                  60                
 Asn Thr Ser Leu Ala Gly Thr Trp Met Glu Gln
  65                  70                  75



      <210> 365
      <211> 186
      <212> PRT
      <213> Homo sapiens


      <400> 365
 Met Leu Lys Ala Lys Ile Leu Phe Val Gly Pro Cys Glu Ser Gly Lys
   1               5                  10                  15    
 Thr Val Leu Ala Asn Phe Leu Thr Glu Ser Ser Asp Ile Thr Glu Tyr
              20                  25                  30        
 Ser Pro Thr Gln Gly Val Arg Ile Leu Glu Phe Glu Asn Pro His Val
          35                  40                  45            
 Thr Ser Asn Asn Lys Gly Thr Gly Cys Glu Phe Glu Leu Trp Asp Cys
      50                  55                  60                
 Gly Gly Asp Ala Lys Phe Glu Ser Cys Trp Pro Ala Leu Met Lys Asp
  65                  70                  75                  80
 Ala His Gly Val Val Ile Val Phe Asn Ala Asp Ile Pro Ser His Arg
                  85                  90                  95    
 Lys Glu Met Glu Met Trp Tyr Ser Cys Phe Val Gln Gln Pro Ser Leu
             100                 105                 110        
 Gln Asp Thr Gln Cys Met Leu Ile Ala His His Lys Pro Gly Ser Gly
         115                 120                 125            
 Asp Asp Lys Gly Ser Leu Ser Leu Ser Pro Pro Leu Asn Lys Leu Lys
     130                 135                 140                
 Leu Val His Ser Asn Leu Glu Asp Asp Pro Glu Glu Ile Arg Met Glu
 145                 150                 155                 160
 Phe Ile Lys Tyr Leu Lys Ser Ile Ile Asn Ser Met Ser Glu Ser Arg
                 165                 170                 175    
 Asp Arg Glu Glu Met Ser Ile Met Thr
             180                 185



      <210> 366
      <211> 247
      <212> PRT
      <213> Homo sapiens


      <400> 366
 Met Ser Gln Met Arg Asn Leu Ile Gln Thr Leu Val Ser Gly Ile Ala
   1               5                  10                  15    
 Pro Ala Thr Arg Ser Arg Ala Thr Pro Gln Ala Leu Leu Leu Asp Ala
              20                  25                  30        
 Leu Cys Leu Leu Leu Asp Ile Leu Ala Pro Lys Leu Arg Pro Val Ser
          35                  40                  45            
 Thr Gln Leu Tyr Ser Thr Arg Glu Lys Gln Gln Leu Ala Ser Leu Val
      50                  55                  60                
 Gly Thr Met Leu Ala Tyr Ser Leu Thr Tyr Arg Gln Glu Arg Thr Pro
  65                  70                  75                  80
 Asp Gly Gln Tyr Ile Tyr Arg Leu Glu Pro Asn Val Glu Glu Leu Cys
                  85                  90                  95    
 Arg Phe Pro Glu Leu Pro Ala Arg Lys Pro Leu Thr Tyr Gln Thr Lys
             100                 105                 110        
 Gln Leu Ile Ala Arg Glu Ile Glu Val Glu Lys Met Arg Arg Ala Glu
         115                 120                 125            
 Ala Ser Ala Arg Val Glu Asn Ser Pro Gln Val Asp Gly Ser Pro Pro
     130                 135                 140                
 Gly Leu Glu Gly Leu Leu Gly Gly Ile Gly Glu Lys Gly Val His Arg
 145                 150                 155                 160
 Pro Ala Pro Arg Asn His Glu Gln Arg Leu Glu His Ile Met Arg Arg
                 165                 170                 175    
 Ala Ala Arg Glu Glu Gln Pro Glu Lys Asp Phe Phe Gly Arg Val Val
             180                 185                 190        
 Val Arg Ser Thr Ala Val Pro Ser Ala Gly Asp Thr Ala Pro Glu Gln
         195                 200                 205            
 Asp Ser Val Glu Arg Arg Met Gly Thr Ala Val Gly Arg Ser Glu Val
     210                 215                 220                
 Trp Phe Arg Phe Asn Glu Gly Val Ser Asn Ala Val Arg Arg Ser Leu
 225                 230                 235                 240
 Tyr Ile Arg Asp Leu Leu
                 245    



      <210> 367
      <211> 25
      <212> PRT
      <213> Homo sapiens


      <400> 367
 Met Pro Val Val Pro Ala Thr Gln Glu Thr Glu Ala Gly Glu Leu Pro
   1               5                  10                  15    
 Glu Pro Gly Arg Gln Arg Leu Gln
              20                



      <210> 368
      <211> 179
      <212> PRT
      <213> Homo sapiens


      <400> 368
 Met Ser Gly Gly Lys Tyr Val Asp Ser Glu Gly His Leu Tyr Thr Val
   1               5                  10                  15    
 Pro Ile Arg Glu Gln Gly Asn Ile Tyr Lys Pro Asn Asn Lys Ala Met
              20                  25                  30        
 Ala Asp Glu Leu Ser Glu Lys Gln Val Tyr Asp Ala His Thr Lys Glu
          35                  40                  45            
 Ile Asp Leu Val Asn Arg Asp Pro Lys His Leu Asn Asp Asp Val Val
      50                  55                  60                
 Lys Ile Asp Phe Glu Asp Val Ile Ala Glu Pro Glu Gly Thr His Ser
  65                  70                  75                  80
 Phe Asp Gly Ile Trp Lys Ala Ser Phe Thr Thr Phe Thr Val Thr Lys
                  85                  90                  95    
 Tyr Trp Phe Tyr Arg Leu Leu Ser Ala Leu Phe Gly Ile Pro Met Ala
             100                 105                 110        
 Leu Ile Trp Gly Ile Tyr Phe Ala Ile Leu Ser Phe Leu His Ile Trp
         115                 120                 125            
 Ala Val Val Pro Cys Ile Lys Ser Phe Leu Ile Glu Ile Gln Cys Ile
     130                 135                 140                
 Ser Arg Val Tyr Ser Ile Tyr Val His Thr Val Cys Asp Pro Leu Phe
 145                 150                 155                 160
 Glu Ala Val Gly Lys Ile Phe Ser Asn Val Arg Ile Asn Leu Gln Lys
                 165                 170                 175    
 Glu Ile
        



      <210> 369
      <211> 61
      <212> PRT
      <213> Homo sapiens


      <400> 369
 Met Val Gln Lys Tyr Ile Phe Pro His Thr Lys Glu Arg Lys Lys Gln
   1               5                  10                  15    
 Arg His Val Ala Gly Gly Glu Gly Arg Pro Asn Pro Asn Thr Leu Gln
              20                  25                  30        
 Gly Ser Met Glu Trp Arg Arg Asn Lys Lys Ile Pro Asn Tyr Phe Gly
          35                  40                  45            
 Val Arg Cys Ala Pro Glu Lys Val Lys Ser Met Gln
      50                  55                  60



      <210> 370
      <211> 330
      <212> PRT
      <213> Homo sapiens


      <400> 370
 Met Glu Val Ala Glu Pro Ser Ser Pro Thr Glu Glu Glu Glu Glu Glu
   1               5                  10                  15    
 Glu Glu His Ser Ala Glu Pro Arg Pro Arg Thr Arg Ser Asn Pro Glu
              20                  25                  30        
 Gly Ala Glu Asp Arg Ala Val Gly Ala Gln Ala Ser Val Gly Ser Arg
          35                  40                  45            
 Ser Glu Gly Glu Gly Glu Ala Ala Ser Ala Asp Asp Gly Ser Leu Asn
      50                  55                  60                
 Thr Ser Gly Ala Gly Pro Lys Ser Trp Gln Val Pro Pro Pro Ala Pro
  65                  70                  75                  80
 Glu Val Gln Ile Arg Thr Pro Arg Val Asn Cys Pro Glu Lys Val Ile
                  85                  90                  95    
 Ile Cys Leu Asp Leu Ser Glu Glu Met Ser Leu Pro Lys Leu Glu Ser
             100                 105                 110        
 Phe Asn Gly Ser Lys Thr Asn Ala Leu Asn Val Ser Gln Lys Met Ile
         115                 120                 125            
 Glu Met Phe Val Arg Thr Lys His Lys Ile Asp Lys Ser His Glu Phe
     130                 135                 140                
 Ala Leu Val Val Val Asn Asp Asp Thr Ala Trp Leu Ser Gly Leu Thr
 145                 150                 155                 160
 Ser Asp Pro Arg Glu Leu Cys Ser Cys Leu Tyr Asp Leu Glu Thr Ala
                 165                 170                 175    
 Ser Cys Ser Thr Phe Asn Leu Glu Gly Leu Phe Ser Leu Ile Gln Gln
             180                 185                 190        
 Lys Thr Glu Leu Pro Val Thr Glu Asn Val Gln Thr Ile Pro Pro Pro
         195                 200                 205            
 Tyr Val Val Arg Thr Ile Leu Val Tyr Ser Arg Pro Pro Cys Gln Pro
     210                 215                 220                
 Gln Phe Ser Leu Thr Glu Pro Met Lys Lys Met Phe Gln Cys Pro Tyr
 225                 230                 235                 240
 Phe Phe Phe Asp Val Val Tyr Ile His Asn Gly Thr Glu Glu Lys Glu
                 245                 250                 255    
 Glu Glu Met Ser Trp Lys Asp Met Phe Ala Phe Met Gly Ser Leu Asp
             260                 265                 270        
 Thr Lys Gly Thr Ser Tyr Lys Tyr Glu Val Ala Leu Ala Gly Pro Ala
         275                 280                 285            
 Leu Glu Leu His Asn Cys Met Ala Lys Leu Leu Ala His Pro Leu Gln
     290                 295                 300                
 Arg Pro Cys Gln Ser His Ala Ser Tyr Ser Leu Leu Glu Glu Glu Asp
 305                 310                 315                 320
 Glu Ala Ile Glu Val Glu Ala Thr Val
                 325                



      <210> 371
      <211> 784
      <212> PRT
      <213> Homo sapiens


      <400> 371
 Met Ser Gly Gly His Gln Leu Gln Leu Ala Ala Leu Trp Pro Trp Leu
   1               5                  10                  15    
 Leu Met Ala Thr Leu Gln Ala Gly Phe Gly Arg Thr Gly Leu Val Leu
              20                  25                  30        
 Ala Ala Ala Val Glu Ser Glu Arg Ser Ala Glu Gln Lys Ala Ile Ile
          35                  40                  45            
 Arg Val Ile Pro Leu Lys Met Asp Pro Thr Gly Lys Leu Asn Leu Thr
      50                  55                  60                
 Leu Glu Gly Val Phe Ala Gly Val Ala Glu Ile Thr Pro Ala Glu Gly
  65                  70                  75                  80
 Lys Leu Met Gln Ser His Pro Leu Tyr Leu Cys Asn Ala Ser Asp Asp
                  85                  90                  95    
 Asp Asn Leu Glu Pro Gly Phe Ile Ser Ile Val Lys Leu Glu Ser Pro
             100                 105                 110        
 Arg Arg Ala Pro Arg Pro Cys Leu Ser Leu Ala Ser Lys Ala Arg Met
         115                 120                 125            
 Ala Gly Glu Arg Gly Ala Ser Ala Val Leu Phe Asp Ile Thr Glu Asp
     130                 135                 140                
 Arg Ala Ala Ala Glu Gln Leu Gln Gln Pro Leu Gly Leu Thr Trp Pro
 145                 150                 155                 160
 Val Val Leu Ile Trp Gly Asn Asp Ala Glu Lys Leu Met Glu Phe Val
                 165                 170                 175    
 Tyr Lys Asn Gln Lys Ala His Val Arg Ile Glu Leu Lys Glu Pro Pro
             180                 185                 190        
 Ala Trp Pro Asp Tyr Asp Val Trp Ile Leu Met Thr Val Val Gly Thr
         195                 200                 205            
 Ile Phe Val Ile Ile Leu Ala Ser Val Leu Arg Ile Arg Cys Arg Pro
     210                 215                 220                
 Arg His Ser Arg Pro Asp Pro Leu Gln Gln Arg Thr Ala Trp Ala Ile
 225                 230                 235                 240
 Ser Gln Leu Ala Thr Arg Arg Tyr Gln Ala Ser Cys Arg Gln Ala Arg
                 245                 250                 255    
 Gly Glu Trp Pro Asp Ser Gly Ser Ser Cys Ser Ser Ala Pro Val Cys
             260                 265                 270        
 Ala Ile Cys Leu Glu Glu Phe Ser Glu Gly Gln Glu Leu Arg Val Ile
         275                 280                 285            
 Ser Cys Leu His Glu Phe His Arg Asn Cys Val Asp Pro Trp Leu His
     290                 295                 300                
 Gln His Arg Thr Cys Pro Leu Cys Val Phe Asn Ile Thr Glu Gly Asp
 305                 310                 315                 320
 Ser Phe Ser Gln Ser Leu Gly Pro Ser Arg Ser Tyr Gln Glu Pro Gly
                 325                 330                 335    
 Arg Arg Leu His Leu Ile Arg Gln His Pro Gly His Ala His Tyr His
             340                 345                 350        
 Leu Pro Ala Ala Tyr Leu Leu Gly Pro Ser Arg Ser Ala Val Ala Arg
         355                 360                 365            
 Pro Pro Arg Pro Gly Pro Phe Leu Pro Ser Gln Glu Pro Gly Met Gly
     370                 375                 380                
 Pro Arg His His Arg Phe Pro Arg Ala Ala His Pro Arg Ala Pro Gly
 385                 390                 395                 400
 Glu Gln Gln Arg Leu Ala Gly Ala Gln His Pro Tyr Ala Gln Gly Trp
                 405                 410                 415    
 Gly Met Ser His Leu Gln Ser Thr Ser Gln His Pro Ala Ala Cys Pro
             420                 425                 430        
 Val Pro Leu Arg Arg Ala Arg Pro Pro Asp Ser Ser Gly Ser Gly Glu
         435                 440                 445            
 Ser Tyr Cys Thr Glu Arg Ser Gly Tyr Leu Ala Asp Gly Pro Ala Ser
     450                 455                 460                
 Asp Ser Ser Ser Gly Pro Cys His Gly Ser Ser Ser Asp Ser Val Val
 465                 470                 475                 480
 Asn Cys Thr Asp Ile Ser Leu Gln Gly Val His Gly Ser Ser Ser Thr
                 485                 490                 495    
 Phe Cys Ser Ser Leu Ser Ser Asp Phe Asp Pro Leu Val Tyr Cys Ser
             500                 505                 510        
 Pro Lys Gly Asp Pro Gln Arg Val Asp Met Gln Pro Ser Val Thr Ser
         515                 520                 525            
 Arg Pro Arg Ser Leu Asp Ser Val Val Pro Thr Gly Glu Thr Gln Val
     530                 535                 540                
 Ser Ser His Val His Tyr His Arg His Arg His His His Tyr Lys Lys
 545                 550                 555                 560
 Arg Phe Gln Trp His Gly Arg Lys Pro Gly Pro Glu Thr Gly Val Pro
                 565                 570                 575    
 Gln Ser Arg Pro Pro Ile Pro Arg Thr Gln Pro Gln Pro Glu Pro Pro
             580                 585                 590        
 Ser Pro Asp Gln Gln Val Thr Arg Ser Asn Ser Ala Ala Pro Ser Gly
         595                 600                 605            
 Arg Leu Ser Asn Pro Gln Cys Pro Arg Ala Leu Pro Glu Pro Ala Pro
     610                 615                 620                
 Gly Pro Val Asp Ala Ser Ser Ile Cys Pro Ser Thr Ser Ser Leu Phe
 625                 630                 635                 640
 Asn Leu Gln Lys Ser Ser Leu Ser Ala Arg His Pro Gln Arg Lys Arg
                 645                 650                 655    
 Arg Gly Gly Pro Ser Glu Pro Thr Pro Gly Ser Arg Pro Gln Asp Ala
             660                 665                 670        
 Thr Val His Pro Ala Cys Gln Ile Phe Pro His Tyr Thr Pro Ser Val
         675                 680                 685            
 Ala Tyr Pro Trp Ser Pro Glu Ala His Pro Leu Ile Cys Gly Pro Pro
     690                 695                 700                
 Gly Leu Asp Lys Arg Leu Leu Pro Glu Thr Pro Gly Pro Cys Tyr Ser
 705                 710                 715                 720
 Asn Ser Gln Pro Val Trp Leu Cys Leu Thr Pro Arg Gln Pro Leu Glu
                 725                 730                 735    
 Pro His Pro Pro Gly Glu Gly Pro Ser Glu Trp Ser Ser Asp Thr Ala
             740                 745                 750        
 Glu Gly Arg Pro Cys Pro Tyr Pro His Cys Gln Val Leu Ser Ala Gln
         755                 760                 765            
 Pro Gly Ser Glu Glu Glu Leu Glu Glu Leu Cys Glu Gln Ala Val
     770                 775                 780            



      <210> 372
      <211> 771
      <212> PRT
      <213> Homo sapiens


      <400> 372
 Met Arg Thr Leu Cys Glu Cys Lys Glu Thr Ala Ser Lys Thr Leu Ser
   1               5                  10                  15    
 Arg Phe Gly Ile Gln Pro Cys Ser Ile Cys Leu Gly Asp Ala Lys Asp
              20                  25                  30        
 Pro Val Cys Leu Pro Cys Asp His Val His Cys Leu Arg Cys Leu Arg
          35                  40                  45            
 Ala Trp Phe Ala Ser Glu Gln Met Ile Cys Pro Tyr Cys Leu Thr Ala
      50                  55                  60                
 Leu Pro Asp Glu Phe Ser Pro Ala Val Ser Gln Ala His Arg Glu Ala
  65                  70                  75                  80
 Ile Glu Lys His Ala Arg Phe Arg Gln Met Cys Asn Ser Phe Phe Val
                  85                  90                  95    
 Asp Leu Val Ser Thr Ile Cys Phe Lys Asp Asn Ala Pro Pro Glu Lys
             100                 105                 110        
 Glu Val Ile Glu Ser Leu Leu Ser Leu Leu Phe Val Gln Lys Gly Arg
         115                 120                 125            
 Leu Arg Asp Ala Ala Gln Arg His Cys Glu His Thr Lys Ser Leu Ser
     130                 135                 140                
 Pro Phe Asn Asp Val Val Asp Lys Thr Pro Val Ile Arg Ser Val Ile
 145                 150                 155                 160
 Leu Lys Leu Leu Leu Lys Tyr Ser Phe His Asp Val Lys Asp Tyr Ile
                 165                 170                 175    
 Gln Glu Tyr Leu Thr Leu Leu Lys Lys Lys Ala Phe Ile Thr Glu Asp
             180                 185                 190        
 Lys Thr Glu Leu Tyr Met Leu Phe Ile Asn Cys Leu Glu Asp Ser Ile
         195                 200                 205            
 Leu Glu Lys Thr Ser Ala Tyr Ser Arg Asn Asp Glu Leu Asn His Leu
     210                 215                 220                
 Glu Glu Glu Gly Arg Phe Leu Lys Ala Tyr Ser Pro Ala Ser Arg Gly
 225                 230                 235                 240
 Arg Glu Pro Ala Asn Glu Ala Ser Val Glu Tyr Leu Gln Glu Val Ala
                 245                 250                 255    
 Arg Ile Arg Leu Cys Leu Asp Arg Ala Ala Asp Phe Leu Ser Gly Pro
             260                 265                 270        
 Glu Gly Gly Pro Glu Met Ala Lys Glu Lys Gln Cys Tyr Leu Gln Gln
         275                 280                 285            
 Val Lys Gln Phe Cys Ile Arg Val Glu Asn Asp Trp His Arg Val Tyr
     290                 295                 300                
 Leu Val Arg Lys Leu Ser Ser Gln Arg Gly Met Glu Phe Val Gln Gly
 305                 310                 315                 320
 Leu Ser Lys Pro Gly Arg Pro His Gln Trp Val Phe Pro Lys Asp Val
                 325                 330                 335    
 Val Lys Gln Gln Gly Leu Arg Gln Asp His Pro Gly Gln Met Asp Arg
             340                 345                 350        
 Tyr Leu Val Tyr Gly Asp Glu Tyr Lys Ala Leu Arg Asp Ala Val Ala
         355                 360                 365            
 Lys Ala Val Leu Glu Cys Lys Pro Leu Gly Ile Lys Thr Ala Leu Lys
     370                 375                 380                
 Ala Cys Lys Thr Pro Gln Ser Gln Gln Ser Ala Tyr Phe Leu Leu Thr
 385                 390                 395                 400
 Leu Phe Arg Glu Val Ala Ile Leu Tyr Arg Ser His Asn Ala Ser Leu
                 405                 410                 415    
 His Pro Thr Pro Glu Gln Cys Glu Ala Val Ser Lys Phe Ile Gly Glu
             420                 425                 430        
 Cys Lys Ile Leu Ser Pro Pro Asp Ile Ser Arg Phe Ala Thr Ser Leu
         435                 440                 445            
 Val Asp Asn Ser Val Pro Leu Leu Arg Ala Gly Pro Ser Asp Ser Asn
     450                 455                 460                
 Leu Asp Gly Thr Val Thr Glu Met Ala Ile His Ala Ala Ala Val Leu
 465                 470                 475                 480
 Leu Cys Gly Gln Asn Glu Leu Leu Glu Pro Leu Lys Asn Leu Ala Phe
                 485                 490                 495    
 Ser Pro Ala Thr Met Ala His Ala Phe Leu Pro Thr Met Pro Glu Asp
             500                 505                 510        
 Leu Leu Ala Gln Ala Arg Arg Trp Lys Gly Leu Glu Arg Val His Trp
         515                 520                 525            
 Tyr Thr Cys Pro Asn Gly His Pro Cys Ser Val Gly Glu Cys Gly Arg
     530                 535                 540                
 Pro Met Glu Gln Ser Ile Cys Ile Asp Cys His Ala Pro Ile Gly Gly
 545                 550                 555                 560
 Ile Asp His Lys Pro Arg Asp Gly Phe His Leu Val Lys Asp Lys Ala
                 565                 570                 575    
 Asp Arg Thr Gln Thr Gly His Val Leu Gly Asn Pro Gln Arg Arg Asp
             580                 585                 590        
 Val Val Thr Cys Asp Arg Gly Leu Pro Pro Val Val Phe Leu Leu Ile
         595                 600                 605            
 Arg Leu Leu Thr His Leu Ala Leu Leu Leu Gly Ala Ser Gln Ser Ser
     610                 615                 620                
 Gln Ala Leu Ile Asn Ile Ile Lys Pro Pro Val Arg Asp Pro Lys Gly
 625                 630                 635                 640
 Phe Leu Gln Gln His Ile Leu Lys Asp Leu Glu Gln Leu Ala Lys Met
                 645                 650                 655    
 Leu Gly His Ser Ala Asp Glu Thr Ile Gly Val Val His Leu Val Leu
             660                 665                 670        
 Arg Arg Leu Leu Gln Glu Gln His Gln Leu Ser Ser Arg Ser Glu Glu
         675                 680                 685            
 Arg Gly Lys Gly Trp Ala Gly Ile Thr Gln His Asn Gly Ser Ala Ser
     690                 695                 700                
 Arg Leu Ala Val Leu Trp Ala Thr Pro His Thr Ala Ser Leu Ser Ser
 705                 710                 715                 720
 Val Cys Ala Val Ala Gly Lys Asn Glu Arg Thr His Arg Glu Lys Thr
                 725                 730                 735    
 Val Ser Arg Glu Gly Asp Ala Trp Gly Trp Lys Lys Glu Ala Leu Cys
             740                 745                 750        
 Leu Pro Arg Gly Trp Lys Glu Leu Leu Cys Ser Leu His Ser Pro Leu
         755                 760                 765            
 Pro Gly
     770



      <210> 373
      <211> 86
      <212> PRT
      <213> Homo sapiens


      <400> 373
 Met Glu Lys Arg Ser Asp Gln Phe Val Cys Val Trp Ile Cys Arg Lys
   1               5                  10                  15    
 Gly Trp Arg Arg Trp Glu Lys Lys Phe Pro Thr Gly Lys Asn Lys Leu
              20                  25                  30        
 Glu Trp Trp Gly Ile Trp Val Cys Gly Gly Gly Gly Ala Gly Gly Pro
          35                  40                  45            
 Pro Gly Ser Ser Met Gly Arg Glu Trp Glu Gln Asp Arg Arg Trp Pro
      50                  55                  60                
 Arg His Arg Arg Leu Met Leu Ser Ser Ser Ala Pro Gly Asp Ser Leu
  65                  70                  75                  80
 Val Trp Ser Gly Thr
                  85



      <210> 374
      <211> 221
      <212> PRT
      <213> Homo sapiens


      <400> 374
 Met Trp Arg Arg Ala Val Ser Ser Val Ala Gly Ser Ala Val Gly Ala
   1               5                  10                  15    
 Glu Pro Gly Leu Arg Leu Leu Ala Val Gln Arg Leu Pro Val Gly Ala
              20                  25                  30        
 Ala Phe Cys Arg Ala Cys Gln Thr Pro Asn Phe Val Arg Gly Leu His
          35                  40                  45            
 Ser Glu Pro Gly Leu Glu Glu Arg Ala Glu Gly Thr Val Asn Glu Gly
      50                  55                  60                
 Arg Pro Glu Ser Asp Ala Ala Asp His Thr Gly Pro Lys Phe Asp Ile
  65                  70                  75                  80
 Asp Met Met Val Ser Leu Leu Arg Gln Glu Asn Ala Arg Asp Ile Cys
                  85                  90                  95    
 Val Ile Gln Val Pro Pro Glu Met Arg Tyr Thr Asp Tyr Phe Val Ile
             100                 105                 110        
 Val Ser Gly Thr Ser Thr Arg His Leu His Ala Met Ala Phe Tyr Val
         115                 120                 125            
 Val Lys Met Tyr Lys His Leu Lys Cys Lys Arg Asp Pro His Val Lys
     130                 135                 140                
 Ile Glu Gly Lys Asp Thr Asp Asp Trp Leu Cys Val Asp Phe Gly Ser
 145                 150                 155                 160
 Met Val Ile His Leu Met Leu Pro Glu Thr Arg Glu Ile Tyr Glu Leu
                 165                 170                 175    
 Glu Lys Leu Trp Thr Leu Arg Ser Tyr Asp Asp Gln Leu Ala Gln Ile
             180                 185                 190        
 Ala Pro Glu Thr Val Pro Glu Asp Phe Ile Leu Gly Ile Glu Asp Asp
         195                 200                 205            
 Thr Ser Ser Val Thr Pro Val Glu Leu Lys Cys Glu
     210                 215                 220



      <210> 375
      <211> 172
      <212> PRT
      <213> Homo sapiens


      <400> 375
 Met Leu Ser Pro Pro Arg Thr Thr Thr Gly Ser Met Thr Ser Trp Gly
   1               5                  10                  15    
 Thr Cys Gly Ser Gly Gln His His Arg Thr Arg Leu Leu Ser Arg Thr
              20                  25                  30        
 Cys Ala Ser Ser Gly Gly His Pro Gly Ser Thr Gln Leu Met Ala Leu
          35                  40                  45            
 Pro Ile Thr Gly Pro Gly Ser Pro Pro Gly Trp Ala Thr Leu Gln Ile
      50                  55                  60                
 Gln Pro Gln Thr Thr Ser Val Ser Ala Val Leu Gln Thr Gln Ala Gly
  65                  70                  75                  80
 Arg Gln Gly Ser Cys Lys Gln Pro Gly Gly Asp Lys Glu Lys Ser Leu
                  85                  90                  95    
 Leu Gly Ser Leu Ser Phe Pro Gly His Val Ala Asn Ser Ala Ile Pro
             100                 105                 110        
 Ser Ser Arg Ala Ser Ala Ser Gly Lys Asn Phe Pro Phe Pro Val Ser
         115                 120                 125            
 His Pro Ser Val Ala Gly Ala Ser His Gln Gly Arg Arg Gly Leu Ser
     130                 135                 140                
 Leu Leu Cys Phe Gly Glu Gly Ala Gln Cys Val Leu Thr Met Ala Gly
 145                 150                 155                 160
 Gly Gln Val Phe Leu Leu Glu Ala Lys Tyr Tyr
                 165                 170    



      <210> 376
      <211> 54
      <212> PRT
      <213> Homo sapiens


      <400> 376
 Met Val Ala Phe Cys Ile Lys Asp Gln Gly His Val Ala Cys Gln Gln
   1               5                  10                  15    
 Gly Gln Gly Pro Arg Ser Gln Pro Ala Arg Gly Leu Gly Gly Ser Ser
              20                  25                  30        
 Ala Pro Pro Arg Leu Pro Gly Ser Arg Gln Gly Leu Pro Arg Thr Pro
          35                  40                  45            
 Ser Trp Val Lys Cys
      50            



      <210> 377
      <211> 455
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(455)
      <223> n = a,t,c or g


      <400> 377
 naagttggta aaggtcagat ccggatgaga actgtttttg aacaggccat tgatcaacgc     60
 tcttcaactg gtgcctggag aaatgctctt tctatttggg aacctgtctg catgaaaatt    120
 ttcgatcgtc tgattaaacc acgctgggag attagataat gaagcgtgcg cctgttttcc    180
 aaaacatacg ctcaatactc aaccggttga agatacttcg ttatcgacac cagctgcccc    240
 catggtggat tcgttaattg cgcgcgtagg agtaatggct cgcggtaatc ccattactta    300
 gcctgtatgt ggtcgggatg tgaagtttac tcttgaagtg ctccggggtg atacgtgccg    360
 ataagccctc tcgggtaggg ccgcgataat gaataagttc agtagcggca tggtttgtcc    420
 cgctctggat gatgtcaggg tacggacatt gaatt                               455



      <210> 378
      <211> 975
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(975)
      <223> n = a,t,c or g


      <400> 378
 aggtagtttt accccctata ccctttaaaa ttttattttt cccctaaagc cttaaatttt     60
 tgtagggagg ttgtcccatt atgtcccccc cccaaagtaa ggtttctttc ccaaaatccc    120
 caggtgggct tttatttaac cccctaaaag gggaaaaata tacccttgcc cgcccccggt    180
 aaactttggc cccccgaagg gttcttttga gggggggccc cgttccnnnn nnnnnnnnct    240
 tttagttaaa ccagtcattt ttattgcttg gagtacacca gaccaaattt atgcgaccca    300
 gggccagagg ctgtaagatg attccatatt tcccaattgg ggagggagga ctccgcttgg    360
 tctttataat atcgaagcca aaacgggtga atcccggctc tcttattaga atccagacgg    420
 gaatttagca tcccttatcc tttctggttc ctctcaagag tgctttcgga acagcaactt    480
 gctttccctt aatttaaatg gtanaaggat cttcaggaaa gatcagggag caaagtcccc    540
 ttggacttta cggaattctt taaaatttta tttgcctggt cacaaaaacg gtacctggtg    600
 cnaacaccca tgtggaatct ccctcaggat ttacacccgg atctgtggaa gggagtaagg    660
 gcccttcctt ggcccagttt ggtaaatctg ctcccttcac cgtcgtcgag aatgtcaacc    720
 ttcaacacaa gtgggggacg ctgcgttgaa taagggtaaa gcccgactgg ggacagggcc    780
 ccttcccggg ggagagaagc agtctcgaag gtgaagtggc ggctagtgcc agagcagccc    840
 agaacatcat cccctcggcc cgctgcccac actccctgtc ttcctcccac cccccgccca    900
 gcaatccggc ttgatgcccc gagctcaccc gggagcatgc atgcgaccca tgatggcggc    960
 gatcggacgc gtggg                                                     975



      <210> 379
      <211> 2039
      <212> DNA
      <213> Homo sapiens


      <400> 379
 gcagggccgg acgccgaagc ctcagagcgc gtgcctgagg gccccgaggc gcccggcgcg     60
 ggcccgtccc gccccctaga gccgcggcca cgtgcgagcg gcaggcccgg acatgcccga    120
 tgcctggcag ttactgtaaa aagacgtgaa cccagcagga ggttcgtcat gagctctggg    180
 cagccttccc tcaaaaaagt cttaggtccg ggaaaacttg aaagtccccc gaaatgggtg    240
 gaataccgtt acaagcctgg cacaaggaca agagagcttg ctcccctacg aatgagaact    300
 tggttctacc acgcgaagct gccttcccac agcgcggcca cctggtacct ccgggggtgg    360
 cgactggggc ttgggctcct atgtaccaga gtatctatga ggggaacgta cagggaaacg    420
 ggcgtcaatg cccaagccac tttcagcccg aggcttccaa gagttgtggg cccgcccggg    480
 tccctccaaa gccctgggag gggcttgaaa aatgggtggg aaaagggacc aagattggcc    540
 ggccgcaaaa cttgacacct tcaagggaca aaagagattt tgggacagaa ttcgccggac    600
 aggttggcag cctgccaaca aagaagcatt taggaccaaa ccatgcttgg gtttaattaa    660
 atttgcctca ttccgtaatc ctggtctggg tctctttttt gagtctcttg ctctgtcgcc    720
 caggctggag tgcagtggcg ccgtctcagc tcactgcaat ctccgccttc tgggttcaaa    780
 tgattctcct gcctcaggcc tcccagggtg ctgggattgc aggtgtgagc cacatgtgcc    840
 tggtctggtt tgggtctctt gattgttctt caggggcatg aggaagaggc gcttcctccc    900
 attcccttgg gtgaaggggg cccaagggtg attgggtggc tgtttaccca ggcagccagt    960
 cgggccttcc caggtcaaac agttcccatc tgggtttttg gaggaaggac ccaggggccc   1020
 ttgtggctca ctcccccaca tcctgtcttt gcaattgtca gaaagtgaga aacgaaagga   1080
 tggctgtgag ctgtgacctc agctgggcct gggcttgcag aggtggcttt ccgctggagt   1140
 aaagtataga ggtcccaggg ttcatgctct tccctggaag gtagaaaagg acagaccacc   1200
 agggagcctc caccgcaaac tgacctgtgc tgcctacaca ctaactttcc tgggcctggg   1260
 gcctgcacag gctgaatggt ccttgagcct tcactctgca tctgagcggt cttgggcccg   1320
 ctgagtggca gtggcaggaa gtcggtggaa gcagatccct gcgcagaagt tgaattacca   1380
 ggggcggcca cacacgggct gcacaacctt tgcagtcgtg cacggcaagt gggatgtggc   1440
 ctccgcccat gattgggcac ctggtcaggc tgggagatcc aaatagcacc cagtgggcag   1500
 ctgtccgacc cctggagggg caagccagga aagaaactta gggcccgctg tgaccagatg   1560
 tccctcccag ttgggaagac taaactggtt tggccaatat ctcccaggat tcccctgtcc   1620
 aaattattcc tgggatctga cccatttcct ggaaaggggc gagcctgggt tttgaagttc   1680
 aaactagagt ttaaatcaca actctgcccc taatcccacg taaccctgtg caccttatcc   1740
 tctgagcctt cgtctcctcg tgtgtaagcc tgctaactcc tgatagactg gacaagatgc   1800
 cgtggagagc cttggctctg agtagctctg ctgctggaca gttcagttgg cagtccccaa   1860
 ccgttaaggc gtaagagttt aagaagtatg ggccaggccc agtggttggc acctgtaatc   1920
 tcaacacttt gggaggccga gacgggctga tcacctgagg ttgggagctt tgagaacagc   1980
 ctgaccaaca tggagaaacc ctgtctctaa aaataccaaa attagttggg catggtggc    2039



      <210> 380
      <211> 548
      <212> DNA
      <213> Homo sapiens


      <400> 380
 tttcgtgtgt gacgttccag gagctagtgg cctcttcacc ctggtgacct ctgttccgta     60
 ttctgtcact gagagacgcc ctgggacatc tgtggtggct tttgtcgcgc tgggacctac    120
 cctgactacg ggagttggga ggacccggga caccgcacag ccgggaaatg gccctgtgtt    180
 atggaacttt ctggggctac cctaagatgc tggaagctgc caatctcatg gagggcctag    240
 tggatatcgg cccttgggtc actcttccca gaggacagcc tgaggtgttg gagtggggcc    300
 tcccaaagga tcaggactca gtggcctttg aggatgtggc tgtgaacttc acccagggag    360
 gagtgggctt tgctgggtcc atcacagaag aatctctaca gagatgtgat gcgagaaacc    420
 attatgaacc tgaactgtat aggaatgaaa tgggaaaacc agaacattga tgatcagcac    480
 caaaatctca ggagaaatcc aaggactcag tgacctttga agatgtggct gtgaacttca    540
 cccaggag                                                             548



      <210> 381
      <211> 519
      <212> DNA
      <213> Homo sapiens


      <400> 381
 cgtctgtggc tttggggtgt cctgggctcc ccatctcctt ctggcccatc tgcctgctgc     60
 cctgagcccc ggttctgtca gggtccctaa gggaggacac tcagggcctg tggccatgca    120
 agggcggagg cctgctgctg ctgatgcctc taggggactt tacaagatgc ccccctacac    180
 acctttcttt ggaacgaagg ctcttctgtc ggtgtccctc ccacccccat gtatgctgca    240
 ctgggttctc tccttcttct tcctgctggc ctgcccaaga actgagggtc tccccggcct    300
 ctactgccct ggctgcaagt caagtgccca gggcgaagga atgtggccag gggatccagg    360
 acctgggatc cagggccctg ggctgggacc tcaggacagg catggaggcc acaggggcca    420
 agcaagccca ccctttcctc tccccactgc ctcctctccc ttcctacact cccagctctg    480
 tattgcgggc gctctggagg atacacgcat acgtcgctc                           519



      <210> 382
      <211> 408
      <212> DNA
      <213> Homo sapiens


      <400> 382
 aattcttgaa gctgcagcag aaatggagtt ataaacacaa acatcaaagg cctatgaatg     60
 gcttcaaggc ccatatgtgt tcggtggtat tcatggctct aacagacccc agcgcccagt    120
 attcagcttg ttggcatccg tacgctgaca gtcttgggtg cccagccaga tctcctatct    180
 tatgaggact tggagctggc agtgggtctc ctgtacagac tgagcttcct gaagaaggat    240
 tcccagagtt gcagggtggc agcactgaaa gcatcaggaa ccctggctgc tctctaccct    300
 gtggccttca gcagccgcct cgtacccaag ctcgctgagg agctgcgtgt aggggagtca    360
 aatttgacta acgccagatg cctcgtgccg ggctgtgcgt gatcatag                 408



      <210> 383
      <211> 469
      <212> DNA
      <213> Homo sapiens


      <400> 383
 tttgagaagg atcgccatgc ttggcacgag ggcgtccacg tggcggtggc gtggggactc     60
 cctgaaagca gagcggtagg gcgcccggaa gtcgtgagtc gagtcttccc gggctaatcc    120
 atgccgggtt ggaggctgct gacgcagggc ggcgcccagg tgctgggtcg actcggggac    180
 ggcctgggtg ctgccctggg cccggggaac agaacacaca tctggctttt tgttagaggt    240
 cttcatggaa agagtggttc atggtgggat gagcatcttt ctgaaaaaaa tgccccattc    300
 attaaacagt tggtccctga tgaaaataaa gcccaattac caagaaaact gtgtcctctg    360
 aaagatgaac catgggctat acttccttgg gaaaccggtt cctttaaagt ttggcttatt    420
 tgacttgaag gctgggcatg ttggcctttc tgtagccacg gtatgggcc                469



      <210> 384
      <211> 445
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(445)
      <223> n = a,t,c or g


      <400> 384
 cgccaccact gagaccttcg tanagngcgg cggaattctg agactacctt tctgcgatca     60
 caggattccc ggcggtgact tgaccccgga agtggggtgt gaagctccgg tgctggtgcg    120
 gcgggggact gcggggccag cctcaggtag cagcagcagc agcagcagca gcagcnnnnn    180
 nnnnnnnnnn nnnnnnnnnn ntgtttcact tcttcagaaa gcctccggaa tctaaaaagc    240
 cctcagtacc agagacagaa gcagatggat tcgtcctttt aggagataca acagatgagc    300
 aaagaatgac agcaagaggc aaaacttcgg acatagaggc caaccaacct ttggagacca    360
 acaaagaaaa ttcatccagt gtgactgtat cagaccctga gatggaaaat aaggcaggcc    420
 agactctgga gaacagctca ttaat                                          445



      <210> 385
      <211> 376
      <212> DNA
      <213> Homo sapiens


      <400> 385
 tttcgtccta gcggagccgg gactggagca acatgaaccg tgaagaccgg aatgtgctgc     60
 gtatgaaaga acgggaaagg cggaatcagg aaattcagca gggcgaagac gccttcccac    120
 ctagctctcc tctctttgca gagccataca aagttactag caaagaagat aagttatcaa    180
 gtcgtattca gagtatgctt ggaaactacg atgaaatgaa ggatttcata ggagacagat    240
 ctataccaaa gcttgttgca attcccaagc ctacagtacc accatcagca gatgaaaaat    300
 ctaacccaaa tttctttgaa cagagacatg gaggctctca tcagagtagc aaatggactc    360
 cagtaggacc cgcacc                                                    376



      <210> 386
      <211> 563
      <212> DNA
      <213> Homo sapiens


      <400> 386
 ttacgccaag cttggcacga ggatcgcggt gcgacgaaag agtaggtggt gggatctcac     60
 cgtgggtccg attagccttt tctctgcctt gcttgcttga gcttcagcgg aattcgaaat    120
 ggctggcggt aaggctggaa aggactccgg aaaggccaag acaaaggcgg tttcccgctc    180
 gcagagagcc ggcttgcagg tcagtagttg ttcgtgcagt ctgggagtca tgatgttttt    240
 ctttgcattt ccttttttgt tattcatcgc tctcgatggg cgttttgtgt atgcgtgggt    300
 gatgcggtgt cgcgacttgg gctgcccata cgataaatat gggggggagg aatcacgtgt    360
 ttcgatgtcg ggacgcgttg ctgcgcccgt gccccttgct ttggcgcgca tataatttcc    420
 ccatctctag ttctcatttt tgtgcattta tgtttgtgta tgcttataat ttaagttccc    480
 agggggccgg attcatcgac acctaaaatc taggacgaac agtcatggac gtgtgggcgc    540
 gactgccgct gtgtacagcg caa                                            563



      <210> 387
      <211> 441
      <212> DNA
      <213> Homo sapiens


      <400> 387
 ggtacacgac aggaatttct gggtcgacga cttcgtgaac caggggtctc ggatgaatgg     60
 ggagtgaggt tgcttttgtt gagcggtgcg attaaggcag atttcctaaa cacgcctgtg    120
 accagctgac tccactcagc gtttccgtgt gagcccagga tggcggacca agtgactttg    180
 gaggacgcgc tgtccaacgt ggacctcctg gaggagctgc ccctgcctga ccagcagccc    240
 tgcatcgagc ccccggcatc ctcgctgctc taccagccaa atttcaacac taactttgaa    300
 gacagaaatg catttgttac tggcatcgca agatacattg aacaagccac cgttcactct    360
 agcatgaacg agatgctgga ggagggccaa gaatatgctg tcatgctgta cacctggagg    420
 agctgttccc gggccattcc c                                              441



      <210> 388
      <211> 619
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(619)
      <223> n = a,t,c or g


      <400> 388
 cgagtcggtc tgcgcagcct cctgcgtttt ctctcttgga tcttggcact gagaggcggt     60
 ggccggcggg aatggagaaa agtaggatga acctgcccaa ggggccggac acgctctgct    120
 tcgacaagga cgagttcatg aaggtgcgcg cggcgtccgc tccccggagc cgggccatga    180
 gggtgcctct gccctgtgcc ctctgtggcc gtctcttcgg tcggctgctc ctgcctgcgc    240
 acgctcagtg tcaggtcctc cgccgagacc tcgctgcact tcgcaatgag tcttttggcg    300
 tcaggtttgg cgggtgcagc ctggagaaag cacttctgta aaatcgtgcg gtgttacatg    360
 gaaaggcctg aaagttctgg gcaagtggtt ttgagctgca tgtcaaagcc actgttaccc    420
 gttcctgtac catgcagtgc agtcagattg ccagtcccct tgtcggaaag aagcttgtgg    480
 acccgggcct ttgagctcat taagtgttgt gtgaataatc tncagcccac gtacttnctt    540
 aggactcggg tcgaaagaaa aagaacttat ctgagttttg cttacatcag ctnagcttca    600
 gatggatatt agagcttaa                                                 619



      <210> 389
      <211> 566
      <212> DNA
      <213> Homo sapiens


      <400> 389
 cttcgtctcc gtccctagtc cgtgtggtgg aattcgggaa gccgagcatg ggcaggaagt     60
 aggggagggc ggtgctccgc cgcggtggcg gttgctatcg cttcgcagaa cctactcagg    120
 cagccagctg agaagagttg agggaaagtg ctgctgctgg ggtctgcaga cgcggatgga    180
 taacgtgcag cccggaaaat aaaacatcgc cccttctgct tcagtgtgaa aggccacggt    240
 gaagatgctg cggctggata ttatcaactc actggtaaca acagtattca tgctcatcgt    300
 atctgtgttg gcactgatac ccagaaacca caaacattga cagttggtgg aggggtgttt    360
 gcacttgtga caagcaagta atgctgcctt gcccgaccgg gggcccctta tttacccgga    420
 aacttctgtt caatccccag ccggtccctt accagaaaaa agcctgtgca tgaaaaaaaa    480
 agaagttttt gtaattttat attacctttt aagtttgata ctaagtatta aaacatattt    540
 ctgtattctt ccaaaaaaaa aaaaaa                                         566



      <210> 390
      <211> 566
      <212> DNA
      <213> Homo sapiens


      <400> 390
 cttcgtctcc gtccctagtc cgtgtggtgg aattcgggaa gccgagcatg ggcaggaagt     60
 aggggagggc ggtgctccgc cgcggtggcg gttgctatcg cttcgcagaa cctactcagg    120
 cagccagctg agaagagttg agggaaagtg ctgctgctgg ggtctgcaga cgcggatgga    180
 taacgtgcag cccggaaaat aaaacatcgc cccttctgct tcagtgtgaa aggccacggt    240
 gaagatgctg cggctggata ttatcaactc actggtaaca acagtattca tgctcatcgt    300
 atctgtgttg gcactgatac ccagaaacca caaacattga cagttggtgg aggggtgttt    360
 gcacttgtga caagcaagta atgctgcctt gcccgaccgg gggcccctta tttacccgga    420
 aacttctgtt caatccccag ccggtccctt accagaaaaa agcctgtgca tgaaaaaaaa    480
 agaagttttt gtaattttat attacctttt aagtttgata ctaagtatta aaacatattt    540
 ctgtattctt ccaaaaaaaa aaaaaa                                         566



      <210> 391
      <211> 1674
      <212> DNA
      <213> Homo sapiens


      <400> 391
 agcggccgcc ggccccggga ctgaccggcc tcgccgcacc tcccgcaccg actagcgctc     60
 ccgggcgctc ctgcgcccga ctcgccctcg cccccactcc ccggcggggt ggcggcggcc    120
 gggcccccac ggcggcggcc ggagcagcag cagcagcagc aggagcccgc ctctatgatg    180
 aagttcaagc ccaaccagac gcggacctac gaccgcgagg gcgttcaaga agcgggcggc    240
 gtgcctcgtg cttccggagc gagcaggagg acgaggtgct gctggtgagt agcagccggt    300
 acccagacca gtggattgtc ccaggaggac ggaatggaac ccgaggagga acttgggcgg    360
 tgctgccgta gggggaagtt tatgaaggag gctgggagtc aaaggaaaac ttaggcagac    420
 ttcctgggca tatttgagca gaaccaagac cgaaagcaca gaacctattg gttagtgttc    480
 taccagtcac tgaaatatta gaagattggg aagattctgt taatattgga aggaagagag    540
 agtggttcaa agtagaagat gctatcaaag ttctccagtg tcataaacct gtacatgcag    600
 agtatctgga aaagctaaag ctgggttgtt ccccagccaa tggaaattct acagtccctt    660
 cccttccgga taataatgcc ttgtttgtaa ccgctgcaca gacctctggg ttgccatcta    720
 gtgtaagata gagagaactg ggtaggcctc tcccaccatg tggcagtctc atgggggaga    780
 gggcttcttt tcgttttcct tcgttcaaac atctgattga cgcttgcaaa ctgtctgaat    840
 ttgccatgca aggttttcaa acaatttgca tgtttttcag atgctttcaa atcttttttt    900
 aaaaaaaata gtgtaaaata ttttaataag ccaaagccat gtggaatttt tgtttagatg    960
 ccttaactgt gccacacccc acaaccccct atattatttt ggttgtctat ttctcacagc   1020
 atattttcag ttttttgtcc atttgacatc agtctgtggt ttattttgtc atcagattac   1080
 ttgggggtat acctacccca aaattgtttt ctcattcaca ggcattagca tattcagcaa   1140
 atccatctag tggtgggaat taaaaatatt attggtatta aagaaatcca ttcaccccca   1200
 aaacttgttt tacaggatta caattttaat tcaaaatttc cagatttggg ctatttctgt   1260
 atgatccaat aacttatttt gtcacagggc ttaatttgcc atttttgggg atttttcgac   1320
 tcattttgtc tgaattttca caactggtat tatgtcacta gctacctgat atggctattt   1380
 cccttataac tcaatagtac cttaacacaa agtataactc tgtagagttg gtgaatattt   1440
 tagggaaata ttagcaaaat gcatgtagta aagacatctt atgaaaactg tattcatgga   1500
 atttgattta gcatgctcag ttgccagttc ccattatcga tactctttct ttgcagaata   1560
 ccttaggaac cgttatttcc ctcagtgtag gattgctctt aaaatgtatt cagttattta   1620
 gtgggccccc acagggagtg ggagtcttgg aaatctaatt ctaaatgcca gtca         1674



      <210> 392
      <211> 2095
      <212> DNA
      <213> Homo sapiens


      <400> 392
 cggccgcgtc gacgccgtgt gcagacccgc gtgtggcgca ggcaaggacc ctcaaaatta     60
 aacagcctct accttgcgat gccgtctttc ccaggcctgc gtccgagtct ccgccgctgc    120
 ggggcccgct ccgacgcgga aagatctgac tgcagccatg agcagcaatg agtgcttcaa    180
 gtgtggacga tctggccact gggcccggga atgtcctact ggtggaggcc gtcgtcgtgg    240
 aattagaagc cgtcgcagag ggtggtttta cctcggatag aggtttccag tttgtttcct    300
 cgtctcttcc agacatttgt tatcgctgtg gtgaagtctg ggtcatcttt gccaaggatt    360
 cgtgaatctt caaggaggat gaagcctgct tattaacttg cggtagaagg ttggccacat    420
 ttgccaagga atttcaaagg agcccaagaa gaagagcgag acaaattgct gctacaactg    480
 ttggcaaacc agggccatct ggctcgtgac tgcgacccat gccgatgacc tgaaatgcta    540
 ttcttgtggg agaattcggg acacattcaa aaaagactgc accaaagtga agtgctatag    600
 gtgtggtgaa actggtcatg tagccatcaa ctgcagcaag acaagtgaag tcaactgtta    660
 ccggctgtgg cgagtcaggg caccttgcac gggaatgcac caattgaggc tacagcccta    720
 attaatttcc ctttgtcgcc cctccttttt ctgattgatg gttgtattat tttctctgaa    780
 tcctcttcac tggccaaagg ttggccagat agaggcaact cccaggccag tgagctttac    840
 ttgccgtgta aaaggaggaa aggggtggaa aaaaaaatcg actttctgca tttaactaca    900
 aaaaaaagtt tatgtttagt ttggtagagg tgttatgtat aatgctttgt taaagaaccc    960
 cctttccgtg ccactgggtg aataggggat tgatgaatgg ggaaggagtt gagtcagacc   1020
 agttaagccc gtcctggggg ttcctttgaa catgttcccc atgtagggag gtaaaaccaa   1080
 ttctggaagt gtctatgaac ttccataaat aaactttaat tttagtatat atgatggtct   1140
 tggattgtct gacctacagt agctatttaa ttaacctcag gtaacatctg tatcaggcgc   1200
 ctcctatgaa ccatacagtt ggagtgggga gttaaacaaa aaggttaaac atgacgtgtt   1260
 aatggctgtt cgagcgaact cgggaataaa agcctaacag agaacaactt tcatcacagt   1320
 gttgatgttg ggacacatta gatggtggat gggcaaaggt tttagaacac cattattttc   1380
 aaagacttaa aattctaaaa ccccagaggt aaacatccaa tgcctcagag ttagcataat   1440
 ttgggagcta ttcaaggaat tgcaagagaa aatgcatttt ccacagaaat ccaaggatgt   1500
 taattttttt gtattactat aatcacttag acgagcggtg tttcatttgc atgtaatcca   1560
 gtttttaaaa agtcagatgg aaagagcata tttatgttcc taaaaaatag aaatggtaat   1620
 tttaaactat tcaaatacag ctggaggagg aaggggagtt ttgactaaag ttctttttgt   1680
 ttgtttacaa attttcatta atggtatata gtgcaaaata ccatattaaa gaggggaatg   1740
 tggaggactg aaagctgaca gtttggactt ttctttttgt acttaagtca tgtcttcaat   1800
 aatgaaaatt gctgttaaaa ggatgtatgg gatttagata cttttgcaaa gctatagaaa   1860
 attcactttg taatctgtta taataatgcc cttgagttct gtgttcagtc tgaacaggtt   1920
 ttttggtggt ggcgccttat tccttagtgt ttcttaaaaa actttgagag agaaaataaa   1980
 caaactcttg actacatttt tacttttgaa gtacaaaaag cagctttcgc tttcaacgaa   2040
 agtgaaattt acatgttgaa ccaccccgcc ctgtgtgaaa taacttttcc ttttt        2095



      <210> 393
      <211> 2095
      <212> DNA
      <213> Homo sapiens


      <400> 393
 cggccgcgtc gacgccgtgt gcagacccgc gtgtggcgca ggcaaggacc ctcaaaatta     60
 aacagcctct accttgcgat gccgtctttc ccaggcctgc gtccgagtct ccgccgctgc    120
 ggggcccgct ccgacgcgga aagatctgac tgcagccatg agcagcaatg agtgcttcaa    180
 gtgtggacga tctggccact gggcccggga atgtcctact ggtggaggcc gtcgtcgtgg    240
 aattagaagc cgtcgcagag ggtggtttta cctcggatag aggtttccag tttgtttcct    300
 cgtctcttcc agacatttgt tatcgctgtg gtgaagtctg ggtcatcttt gccaaggatt    360
 cgtgaatctt caaggaggat gaagcctgct tattaacttg cggtagaagg ttggccacat    420
 ttgccaagga atttcaaagg agcccaagaa gaagagcgag acaaattgct gctacaactg    480
 ttggcaaacc agggccatct ggctcgtgac tgcgacccat gccgatgacc tgaaatgcta    540
 ttcttgtggg agaattcggg acacattcaa aaaagactgc accaaagtga agtgctatag    600
 gtgtggtgaa actggtcatg tagccatcaa ctgcagcaag acaagtgaag tcaactgtta    660
 ccggctgtgg cgagtcaggg caccttgcac gggaatgcac caattgaggc tacagcccta    720
 attaatttcc ctttgtcgcc cctccttttt ctgattgatg gttgtattat tttctctgaa    780
 tcctcttcac tggccaaagg ttggccagat agaggcaact cccaggccag tgagctttac    840
 ttgccgtgta aaaggaggaa aggggtggaa aaaaaaatcg actttctgca tttaactaca    900
 aaaaaaagtt tatgtttagt ttggtagagg tgttatgtat aatgctttgt taaagaaccc    960
 cctttccgtg ccactgggtg aataggggat tgatgaatgg ggaaggagtt gagtcagacc   1020
 agttaagccc gtcctggggg ttcctttgaa catgttcccc atgtagggag gtaaaaccaa   1080
 ttctggaagt gtctatgaac ttccataaat aaactttaat tttagtatat atgatggtct   1140
 tggattgtct gacctacagt agctatttaa ttaacctcag gtaacatctg tatcaggcgc   1200
 ctcctatgaa ccatacagtt ggagtgggga gttaaacaaa aaggttaaac atgacgtgtt   1260
 aatggctgtt cgagcgaact cgggaataaa agcctaacag agaacaactt tcatcacagt   1320
 gttgatgttg ggacacatta gatggtggat gggcaaaggt tttagaacac cattattttc   1380
 aaagacttaa aattctaaaa ccccagaggt aaacatccaa tgcctcagag ttagcataat   1440
 ttgggagcta ttcaaggaat tgcaagagaa aatgcatttt ccacagaaat ccaaggatgt   1500
 taattttttt gtattactat aatcacttag acgagcggtg tttcatttgc atgtaatcca   1560
 gtttttaaaa agtcagatgg aaagagcata tttatgttcc taaaaaatag aaatggtaat   1620
 tttaaactat tcaaatacag ctggaggagg aaggggagtt ttgactaaag ttctttttgt   1680
 ttgtttacaa attttcatta atggtatata gtgcaaaata ccatattaaa gaggggaatg   1740
 tggaggactg aaagctgaca gtttggactt ttctttttgt acttaagtca tgtcttcaat   1800
 aatgaaaatt gctgttaaaa ggatgtatgg gatttagata cttttgcaaa gctatagaaa   1860
 attcactttg taatctgtta taataatgcc cttgagttct gtgttcagtc tgaacaggtt   1920
 ttttggtggt ggcgccttat tccttagtgt ttcttaaaaa actttgagag agaaaataaa   1980
 caaactcttg actacatttt tacttttgaa gtacaaaaag cagctttcgc tttcaacgaa   2040
 agtgaaattt acatgttgaa ccaccccgcc ctgtgtgaaa taacttttcc ttttt        2095



      <210> 394
      <211> 1316
      <212> DNA
      <213> Homo sapiens


      <400> 394
 cggacgcgtg ggctgaccag caccatggcg gttggcaaga acaagcgcct tacgaaaggc     60
 ggcaaaaagg gagccaagaa gaaagtgtaa gtcgcgactg tcgtggcgtc ttgctttttg    120
 ggggtctgct ggaatcggcg ggctggtcct agatcgcggc gtaggccgga tggcgaggat    180
 tccagtcgga ttgtgcgggc cgtggcgggt tggtgcaccc aggaacgcgg cctggagggt    240
 cggtgttgag tagcggcagg gttgatccag ttttctagga aagattgggt atgatgtgaa    300
 agcaccctgc tatgttcaat ataagaacat attggaaaga cgctccgtca ccagggaccc    360
 aaggaaccca attttgcatc ctgatggtct ccaagggtcg tgtgttttga agtgagtcct    420
 tgctggattt gcagaatgaa tgaagtttgc attttaggaa aattccaagc tggatttact    480
 tgaagattgt tccaggggta aaaacttgcc ctgacttaac tttcccatgg ggcattggga    540
 tcctttaccc cgtgaccaaa aatgtgtttc catgggtcca aaaaaatggc cagaccaatg    600
 attggaagct ccacgtttga tggtccaaga cctacccgat gggttacttt gctttcgtct    660
 tgttcttgtt gtttgggttt tacttaaaaa acggcaacaa tccagattac ggaaagacct    720
 ctttatggct tcaggcaccc caacagggtc ccgccaaaat ccgggaagga agatggatgg    780
 gaaatccatg acccccgaga ggtggcagga ccaaatggac ttggaaagga agtggttcca    840
 taaattgatt cccagacagc atttggaaaa agacctagaa aaggcttgcc caatcctatt    900
 tatcctcttc catgaatgtc ttcgttagaa aaagtaaaaa tgctgaaaaa accccaagtt    960
 ttgaattggg aaaagctcat ggagcttcca tggttaaggc agtaggtcct ggaaaagcac   1020
 ctggggacga gacaggtgct aaacgttgaa ccgagctgca tggatatgaa ccacacagtc   1080
 caagaatctg tttaaagttc agacttcaaa tagtggcaaa taaaaactgc tatttgtgaa   1140
 aaaaggagaa agaaaaaaaa aagggggggg ccctttttaa aaaatccttg gggggcccaa   1200
 atttaaccgg gggtgggaag gcaaaatttt tttctttttg ggggggggtt taataccctc   1260
 cttgggaatt ttggaaagga accttttttt tgggggggga aaaaaatgga acaacc       1316



      <210> 395
      <211> 1382
      <212> DNA
      <213> Homo sapiens


      <400> 395
 tttttttttt tttacattta tgtagtattt tatagttaat taagacttta taatactgat     60
 gtgaaatgag gagttggaac aaatggtttc taagatactt tccagctctg aaatgtgcag    120
 cttccttctc tagggcaagt cccacctatt caggcccagc tccagtgcca tccatcctct    180
 ccaggaagcc ttccccatat tctagctccc actgatgtct cttagctgaa acctgaattg    240
 gcactgccct caaaagacaa ctcttgtctc cccaagtaat ttgcaaacct cttgagaaca    300
 gggtgtatat tttcttattc atattctcca ttgtacctgg catagggcta ggccactagg    360
 ttgtgttggc tgcctggtgt tgggggtgca ggggcccagg gtctagtcat gacttgtgac    420
 tgggttcact acgagacctc cagaaggtca cgacactgtg gcctcagttt tatcatccat    480
 ccagtgaggc atttatgcac cccctcctaa tgttattggg ggatgggact ccatgaagaa    540
 attcaaggaa agcagttcat gcttcccaag ggaaccctgg tggtaggggt ggtttctgat    600
 gggtctagct agtgagagct ccacaccttg ccctttccct ggagaggcaa agatgcacac    660
 actgcctccc ttcccctcct gccctgtata caggaccata gcaggggaga aagggaaggg    720
 ttgatcttgc ctttcccttc aggattgtgt ggctgacatg ctgaccggca gatgactcca    780
 ggcttgctgt gtgtctggcg gtcagggcca gaattcacat tattgacccg cattccagga    840
 tttgggtagg tgaggcagaa agggtagagg gcttcctgag atagcttcag gctggggagt    900
 aggatttgat ctgggcaaaa caaagttggg tgtcaccctt gcagagttcc gtgcccctct    960
 gtgcagctgt ggcaggggat catagcagca ggctatggga acggacaagt gcatctatat   1020
 gaggccactt acaggaaatc tacatgtcca gatcaatgcc catgcccggg ccatctgcgc   1080
 cctggacctg gcttctgagg tgggcaagct actctctgca ggtgaggaca cctttgtgca   1140
 tatctggaag ctgagcagaa acccagagag tgggctacat tgaggtggaa ccctgtcatg   1200
 gtgagtgtgt cgccgacacc cagctgtgtg gtgctcgatt ttgtgatttc ccaaggcaac   1260
 tcctttgctg tgactggcta tgaccttgcg gagatccgga gattcagcag tgtgtgagaa   1320
 gagcagcctt cctttgtccc tgtggtattc ataaagtacc cgctccaccc aaaaaaaaaa   1380
 aa                                                                  1382



      <210> 396
      <211> 1382
      <212> DNA
      <213> Homo sapiens


      <400> 396
 tttttttttt tttacattta tgtagtattt tatagttaat taagacttta taatactgat     60
 gtgaaatgag gagttggaac aaatggtttc taagatactt tccagctctg aaatgtgcag    120
 cttccttctc tagggcaagt cccacctatt caggcccagc tccagtgcca tccatcctct    180
 ccaggaagcc ttccccatat tctagctccc actgatgtct cttagctgaa acctgaattg    240
 gcactgccct caaaagacaa ctcttgtctc cccaagtaat ttgcaaacct cttgagaaca    300
 gggtgtatat tttcttattc atattctcca ttgtacctgg catagggcta ggccactagg    360
 ttgtgttggc tgcctggtgt tgggggtgca ggggcccagg gtctagtcat gacttgtgac    420
 tgggttcact acgagacctc cagaaggtca cgacactgtg gcctcagttt tatcatccat    480
 ccagtgaggc atttatgcac cccctcctaa tgttattggg ggatgggact ccatgaagaa    540
 attcaaggaa agcagttcat gcttcccaag ggaaccctgg tggtaggggt ggtttctgat    600
 gggtctagct agtgagagct ccacaccttg ccctttccct ggagaggcaa agatgcacac    660
 actgcctccc ttcccctcct gccctgtata caggaccata gcaggggaga aagggaaggg    720
 ttgatcttgc ctttcccttc aggattgtgt ggctgacatg ctgaccggca gatgactcca    780
 ggcttgctgt gtgtctggcg gtcagggcca gaattcacat tattgacccg cattccagga    840
 tttgggtagg tgaggcagaa agggtagagg gcttcctgag atagcttcag gctggggagt    900
 aggatttgat ctgggcaaaa caaagttggg tgtcaccctt gcagagttcc gtgcccctct    960
 gtgcagctgt ggcaggggat catagcagca ggctatggga acggacaagt gcatctatat   1020
 gaggccactt acaggaaatc tacatgtcca gatcaatgcc catgcccggg ccatctgcgc   1080
 cctggacctg gcttctgagg tgggcaagct actctctgca ggtgaggaca cctttgtgca   1140
 tatctggaag ctgagcagaa acccagagag tgggctacat tgaggtggaa ccctgtcatg   1200
 gtgagtgtgt cgccgacacc cagctgtgtg gtgctcgatt ttgtgatttc ccaaggcaac   1260
 tcctttgctg tgactggcta tgaccttgcg gagatccgga gattcagcag tgtgtgagaa   1320
 gagcagcctt cctttgtccc tgtggtattc ataaagtacc cgctccaccc aaaaaaaaaa   1380
 aa                                                                  1382



      <210> 397
      <211> 1925
      <212> DNA
      <213> Homo sapiens


      <400> 397
 tgtcccggtc ggatttcccg gcccgacgat ttcgtggcgc cgacggtttc ccggccctgg     60
 cctgttgctt ggaggagaag ctgagcctgt gcttccgccc atcggatccg ggcgccgagc    120
 caccgaggac ggccgtgcgg ccccatcacg gagcgcagcc tcctgcaggg ggacgagatt    180
 tgaaatgccc tgacagataa attatgggaa tgtgatgcct gtagactgga agtcatcgca    240
 tactaggacc ttgcacttgc ttactctgaa cctctcaaaa aaaggggtaa gtgacagttt    300
 gctctttgat acatcagatg atgaagagct gagagaacag ctggattatg cactcaatca    360
 tcgtctcctg tggtaaggag tgaaccgctc ttcacggcag acccaggtta ttgaagaaaa    420
 ttgaagaatt gatgcaggaa tcaccggacc cagatgatta tgaaacccct acaccagtca    480
 gatcggcttt caatgctttc ccaggaaatt caaactctca agaaggtcta ttaccggcag    540
 ttatgaagag agagtgaaaa ggctctcagt gtctgagtta aatgaaatcc tggaagaaac    600
 tgagactgcc attaaggagt actctgagga gctggtgcag cagttggctt tacgagatga    660
 tactgtagtt tgaaaaggaa gtgaaaaaca gctttatttc tgttcttatt gaagtgcaaa    720
 acaaacagaa agagcacaaa gaaacagcaa aaaaagaaaa agaaactaaa aaatgggcag    780
 ctctcagaat gggaagaatg agagaagtca tatgcccggc acatatttga ctacagtcat    840
 tccttatgag aaaaaaaaac ggaccaccgt ctgttgaaga tcttcaaata ttaacaaaaa    900
 ttctttgtgc catgaaggag gacagtgaaa aagttccgag cttgttaacc tgattatatt    960
 cctgaaagtt ctgtgtccta catagagcag caactttatc tgccggtggg ctccaagcta   1020
 gatttcccga cagcattatt cctgagagct ggctaccatt acccttcttg ctattggaaa   1080
 ctcagcacat ttgaacttgg gtttgattca gtattaacag atcttgacta cactaattct   1140
 ttatattata gaaccaacgg aaatatgggc actatttttg gaattctaga gatgggtttt   1200
 tgttaaatct acttaataaa ctgttctctt agtagattaa gagagagtaa tattaattgt   1260
 gcatgtgcgg ttgtatttct cattaactga cagtatgccc atttgttttt atggctttct   1320
 tatctaaact gcactgatga actagattaa agccttggga gatttatact ataaattcag   1380
 tgatggcaag aaccaacact gtttttttgt gagaattgtc agtgtaacta ttacctacca   1440
 gtattgttca gagagattga aacagaataa acgggctgtt cttgaagaag ccaaacccca   1500
 atatagcatt cccttggggt ttaatactta gtgcttaaca ttgaaactgt tggtgtgtga   1560
 tggattttgt agcttgctgc ttgtttcacc actggtcaaa ttttaaccat taaaattgcc   1620
 attcactttt agaatcttgt atttaagtaa gttttgattt tcaaatgttc tgcttcatgt   1680
 gtctgtgaag aattgtactt ttttaaaaag tgtggtgtcc tctgaggtgc ttgagaaagt   1740
 gtacactggc agaactgccc attctcatta ctgtgtccta ttttaattca tgcctgtgtg   1800
 tttttcttaa gtatgaattc tagatacagc tacttatggg attcatcaat atcatgagca   1860
 cttttgctgg ttccagtcaa atcaatggca tttaataaat tttattaaga agtaaaaaaa   1920
 aaaaa                                                               1925



      <210> 398
      <211> 1925
      <212> DNA
      <213> Homo sapiens


      <400> 398
 tgtcccggtc ggatttcccg gcccgacgat ttcgtggcgc cgacggtttc ccggccctgg     60
 cctgttgctt ggaggagaag ctgagcctgt gcttccgccc atcggatccg ggcgccgagc    120
 caccgaggac ggccgtgcgg ccccatcacg gagcgcagcc tcctgcaggg ggacgagatt    180
 tgaaatgccc tgacagataa attatgggaa tgtgatgcct gtagactgga agtcatcgca    240
 tactaggacc ttgcacttgc ttactctgaa cctctcaaaa aaaggggtaa gtgacagttt    300
 gctctttgat acatcagatg atgaagagct gagagaacag ctggattatg cactcaatca    360
 tcgtctcctg tggtaaggag tgaaccgctc ttcacggcag acccaggtta ttgaagaaaa    420
 ttgaagaatt gatgcaggaa tcaccggacc cagatgatta tgaaacccct acaccagtca    480
 gatcggcttt caatgctttc ccaggaaatt caaactctca agaaggtcta ttaccggcag    540
 ttatgaagag agagtgaaaa ggctctcagt gtctgagtta aatgaaatcc tggaagaaac    600
 tgagactgcc attaaggagt actctgagga gctggtgcag cagttggctt tacgagatga    660
 tactgtagtt tgaaaaggaa gtgaaaaaca gctttatttc tgttcttatt gaagtgcaaa    720
 acaaacagaa agagcacaaa gaaacagcaa aaaaagaaaa agaaactaaa aaatgggcag    780
 ctctcagaat gggaagaatg agagaagtca tatgcccggc acatatttga ctacagtcat    840
 tccttatgag aaaaaaaaac ggaccaccgt ctgttgaaga tcttcaaata ttaacaaaaa    900
 ttctttgtgc catgaaggag gacagtgaaa aagttccgag cttgttaacc tgattatatt    960
 cctgaaagtt ctgtgtccta catagagcag caactttatc tgccggtggg ctccaagcta   1020
 gatttcccga cagcattatt cctgagagct ggctaccatt acccttcttg ctattggaaa   1080
 ctcagcacat ttgaacttgg gtttgattca gtattaacag atcttgacta cactaattct   1140
 ttatattata gaaccaacgg aaatatgggc actatttttg gaattctaga gatgggtttt   1200
 tgttaaatct acttaataaa ctgttctctt agtagattaa gagagagtaa tattaattgt   1260
 gcatgtgcgg ttgtatttct cattaactga cagtatgccc atttgttttt atggctttct   1320
 tatctaaact gcactgatga actagattaa agccttggga gatttatact ataaattcag   1380
 tgatggcaag aaccaacact gtttttttgt gagaattgtc agtgtaacta ttacctacca   1440
 gtattgttca gagagattga aacagaataa acgggctgtt cttgaagaag ccaaacccca   1500
 atatagcatt cccttggggt ttaatactta gtgcttaaca ttgaaactgt tggtgtgtga   1560
 tggattttgt agcttgctgc ttgtttcacc actggtcaaa ttttaaccat taaaattgcc   1620
 attcactttt agaatcttgt atttaagtaa gttttgattt tcaaatgttc tgcttcatgt   1680
 gtctgtgaag aattgtactt ttttaaaaag tgtggtgtcc tctgaggtgc ttgagaaagt   1740
 gtacactggc agaactgccc attctcatta ctgtgtccta ttttaattca tgcctgtgtg   1800
 tttttcttaa gtatgaattc tagatacagc tacttatggg attcatcaat atcatgagca   1860
 cttttgctgg ttccagtcaa atcaatggca tttaataaat tttattaaga agtaaaaaaa   1920
 aaaaa                                                               1925



      <210> 399
      <211> 2317
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2317)
      <223> n = a,t,c or g


      <400> 399
 ctcccccaac cttatcccgc ccctgggggt tcgcgggcat ttttcaggaa ctttctttcc     60
 ggcttgagaa gccgccactc ccaagatgga gcaggaaccn gcggctgctg gacaagaggg    120
 gtgcggtgga tactgacctt tgctccggcc tcgtgtagcg tgaagacaca gcgcatctcc    180
 ccgctgtagg cttcctccca cagaacccgt ttcgggccat cagagcagtc tggtgagatg    240
 ctgttgccgc tgctgctgct gctacccatg tgctgggccg tggaggtcaa gaggccccgg    300
 tgcgtcgtcc ctcaccaatc gtggcttcta cgatgagtcc aaagcctttc acctggcctg    360
 gacggttcgg ccaccatccc atttgatcaa ggtcaacgat gacctattgc gactgcaaag    420
 aatggctctt gacgaagcca ggcaacggct gcctggtcct taatgggcaa gctttccact    480
 ggccaccaaa cacttgggct ataaagcccc ttgtaataat ccccttccaa accggggtca    540
 aacgatggtg tttgtgactg ctgcgatgga acagacgaag tacaacaagc ggcgtcatct    600
 ggtgagaaca cctgcaaaga agaagggccc gtaaggagaa gagagtccct gcagcagatg    660
 gcccgaggtc acccgcgaag gggttccgtc ttgaagaaga tcccttattt gagggactgg    720
 gaaagaaggc acgggaggag aagcagaaaa agcttcattg agctacaggc tgggaagaag    780
 tctctggaag accagtgtgg agatgctgcg gacagtgaag gaggaagctg agaagccaga    840
 gagagaggcc aaagagcagc accagaagct gtgggaaaga acagctggct ggcttccaag    900
 gccccaacag ggagcaggac gctagggcgg ctgatgcctt caaggagctg gatgatgaca    960
 tggaccggga cggtctcggt gactgagctg cagactcacc cggagctgga cacagattgg   1020
 ggatgggggc gttgttagaa gcggaagctc aggccctcct cagtggggac acacagacag   1080
 acgccacctc tttctacgac cgcgtctggg ccgccatcag ggacaagtac cggtccgagg   1140
 cactgcccac cgaccttcca acagccttct gcccctgact tgacggagcc caaggaggag   1200
 cagccgccag tgccctcgtc gcccacagag gaggaggagg aggaggagga ggaggaggaa   1260
 gaacaggctg aagaagagga ggaggaggag gattccgagg tgcaggggga gcagcccaag   1320
 gaggccccac cgccacttgt cacccccgca gccgggcaga cctgctgtag gaagacaaaa   1380
 tgccgcccta cgacgagcag acgcaggccc ttcatcgatg ctgcccagga ggcccgcaac   1440
 aagttcgagg aggccgagcg gtctctgaag gacatggagg agtccatcag gaaccatgga   1500
 gcaagagatt tcttttgact ttggccccaa cgcgacgtgt tgcttacctg tacagccagt   1560
 gcatacgagc tcaccaccaa cgaatacgtc tacccgcctc tgccccttca agcttggtct   1620
 cgcagaaacc caaactcggg gggctctccc accaagcctt gggcacctgg gggcttcatg   1680
 ggattgggcc ccgaccacgg acaagtttca gttgccatga agttttgagc aaggcacggg   1740
 gcttgctggc aggggcccca accgctccag catccgtgac gcttctggtt cgggaaaagg   1800
 gaacatggtg accagctacc acagagccca agtggctgcg agtaccttca tggaagttga   1860
 tgaacgccag ccgccttgcc cggagccacc cgccttgaag caaccccaac cgaaagacgg   1920
 accatgacga gctcttagct tgggatgggc gcaagagaac cttcaaggaa ggcatgaagc   1980
 caagcccctt gcagttgccg ttccacccgc cccctctggg gcttgcctgt ggcttcttgt   2040
 tgccctcctc tgtgggcggc agggaccttt gtgggggctt cgtgccttgc ttcttggggg   2100
 cccagggcgg ggcttggttc cacattccca ggcccccaac agccttcaaa gatgggttaa   2160
 gggagcttgc cctccctggg cccccccacc ttggtgactc gccccaccac ccccagccct   2220
 gtccctgcca cccctcctag tgggggactt agtgaattga tttgaccttg ttgaccttca   2280
 atacaattaa atgttgatcc cccacccaaa aaaaaaa                            2317



      <210> 400
      <211> 2317
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2317)
      <223> n = a,t,c or g


      <400> 400
 ctcccccaac cttatcccgc ccctgggggt tcgcgggcat ttttcaggaa ctttctttcc     60
 ggcttgagaa gccgccactc ccaagatgga gcaggaaccn gcggctgctg gacaagaggg    120
 gtgcggtgga tactgacctt tgctccggcc tcgtgtagcg tgaagacaca gcgcatctcc    180
 ccgctgtagg cttcctccca cagaacccgt ttcgggccat cagagcagtc tggtgagatg    240
 ctgttgccgc tgctgctgct gctacccatg tgctgggccg tggaggtcaa gaggccccgg    300
 tgcgtcgtcc ctcaccaatc gtggcttcta cgatgagtcc aaagcctttc acctggcctg    360
 gacggttcgg ccaccatccc atttgatcaa ggtcaacgat gacctattgc gactgcaaag    420
 aatggctctt gacgaagcca ggcaacggct gcctggtcct taatgggcaa gctttccact    480
 ggccaccaaa cacttgggct ataaagcccc ttgtaataat ccccttccaa accggggtca    540
 aacgatggtg tttgtgactg ctgcgatgga acagacgaag tacaacaagc ggcgtcatct    600
 ggtgagaaca cctgcaaaga agaagggccc gtaaggagaa gagagtccct gcagcagatg    660
 gcccgaggtc acccgcgaag gggttccgtc ttgaagaaga tcccttattt gagggactgg    720
 gaaagaaggc acgggaggag aagcagaaaa agcttcattg agctacaggc tgggaagaag    780
 tctctggaag accagtgtgg agatgctgcg gacagtgaag gaggaagctg agaagccaga    840
 gagagaggcc aaagagcagc accagaagct gtgggaaaga acagctggct ggcttccaag    900
 gccccaacag ggagcaggac gctagggcgg ctgatgcctt caaggagctg gatgatgaca    960
 tggaccggga cggtctcggt gactgagctg cagactcacc cggagctgga cacagattgg   1020
 ggatgggggc gttgttagaa gcggaagctc aggccctcct cagtggggac acacagacag   1080
 acgccacctc tttctacgac cgcgtctggg ccgccatcag ggacaagtac cggtccgagg   1140
 cactgcccac cgaccttcca acagccttct gcccctgact tgacggagcc caaggaggag   1200
 cagccgccag tgccctcgtc gcccacagag gaggaggagg aggaggagga ggaggaggaa   1260
 gaacaggctg aagaagagga ggaggaggag gattccgagg tgcaggggga gcagcccaag   1320
 gaggccccac cgccacttgt cacccccgca gccgggcaga cctgctgtag gaagacaaaa   1380
 tgccgcccta cgacgagcag acgcaggccc ttcatcgatg ctgcccagga ggcccgcaac   1440
 aagttcgagg aggccgagcg gtctctgaag gacatggagg agtccatcag gaaccatgga   1500
 gcaagagatt tcttttgact ttggccccaa cgcgacgtgt tgcttacctg tacagccagt   1560
 gcatacgagc tcaccaccaa cgaatacgtc tacccgcctc tgccccttca agcttggtct   1620
 cgcagaaacc caaactcggg gggctctccc accaagcctt gggcacctgg gggcttcatg   1680
 ggattgggcc ccgaccacgg acaagtttca gttgccatga agttttgagc aaggcacggg   1740
 gcttgctggc aggggcccca accgctccag catccgtgac gcttctggtt cgggaaaagg   1800
 gaacatggtg accagctacc acagagccca agtggctgcg agtaccttca tggaagttga   1860
 tgaacgccag ccgccttgcc cggagccacc cgccttgaag caaccccaac cgaaagacgg   1920
 accatgacga gctcttagct tgggatgggc gcaagagaac cttcaaggaa ggcatgaagc   1980
 caagcccctt gcagttgccg ttccacccgc cccctctggg gcttgcctgt ggcttcttgt   2040
 tgccctcctc tgtgggcggc agggaccttt gtgggggctt cgtgccttgc ttcttggggg   2100
 cccagggcgg ggcttggttc cacattccca ggcccccaac agccttcaaa gatgggttaa   2160
 gggagcttgc cctccctggg cccccccacc ttggtgactc gccccaccac ccccagccct   2220
 gtccctgcca cccctcctag tgggggactt agtgaattga tttgaccttg ttgaccttca   2280
 atacaattaa atgttgatcc cccacccaaa aaaaaaa                            2317



      <210> 401
      <211> 2317
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2317)
      <223> n = a,t,c or g


      <400> 401
 ctcccccaac cttatcccgc ccctgggggt tcgcgggcat ttttcaggaa ctttctttcc     60
 ggcttgagaa gccgccactc ccaagatgga gcaggaaccn gcggctgctg gacaagaggg    120
 gtgcggtgga tactgacctt tgctccggcc tcgtgtagcg tgaagacaca gcgcatctcc    180
 ccgctgtagg cttcctccca cagaacccgt ttcgggccat cagagcagtc tggtgagatg    240
 ctgttgccgc tgctgctgct gctacccatg tgctgggccg tggaggtcaa gaggccccgg    300
 tgcgtcgtcc ctcaccaatc gtggcttcta cgatgagtcc aaagcctttc acctggcctg    360
 gacggttcgg ccaccatccc atttgatcaa ggtcaacgat gacctattgc gactgcaaag    420
 aatggctctt gacgaagcca ggcaacggct gcctggtcct taatgggcaa gctttccact    480
 ggccaccaaa cacttgggct ataaagcccc ttgtaataat ccccttccaa accggggtca    540
 aacgatggtg tttgtgactg ctgcgatgga acagacgaag tacaacaagc ggcgtcatct    600
 ggtgagaaca cctgcaaaga agaagggccc gtaaggagaa gagagtccct gcagcagatg    660
 gcccgaggtc acccgcgaag gggttccgtc ttgaagaaga tcccttattt gagggactgg    720
 gaaagaaggc acgggaggag aagcagaaaa agcttcattg agctacaggc tgggaagaag    780
 tctctggaag accagtgtgg agatgctgcg gacagtgaag gaggaagctg agaagccaga    840
 gagagaggcc aaagagcagc accagaagct gtgggaaaga acagctggct ggcttccaag    900
 gccccaacag ggagcaggac gctagggcgg ctgatgcctt caaggagctg gatgatgaca    960
 tggaccggga cggtctcggt gactgagctg cagactcacc cggagctgga cacagattgg   1020
 ggatgggggc gttgttagaa gcggaagctc aggccctcct cagtggggac acacagacag   1080
 acgccacctc tttctacgac cgcgtctggg ccgccatcag ggacaagtac cggtccgagg   1140
 cactgcccac cgaccttcca acagccttct gcccctgact tgacggagcc caaggaggag   1200
 cagccgccag tgccctcgtc gcccacagag gaggaggagg aggaggagga ggaggaggaa   1260
 gaacaggctg aagaagagga ggaggaggag gattccgagg tgcaggggga gcagcccaag   1320
 gaggccccac cgccacttgt cacccccgca gccgggcaga cctgctgtag gaagacaaaa   1380
 tgccgcccta cgacgagcag acgcaggccc ttcatcgatg ctgcccagga ggcccgcaac   1440
 aagttcgagg aggccgagcg gtctctgaag gacatggagg agtccatcag gaaccatgga   1500
 gcaagagatt tcttttgact ttggccccaa cgcgacgtgt tgcttacctg tacagccagt   1560
 gcatacgagc tcaccaccaa cgaatacgtc tacccgcctc tgccccttca agcttggtct   1620
 cgcagaaacc caaactcggg gggctctccc accaagcctt gggcacctgg gggcttcatg   1680
 ggattgggcc ccgaccacgg acaagtttca gttgccatga agttttgagc aaggcacggg   1740
 gcttgctggc aggggcccca accgctccag catccgtgac gcttctggtt cgggaaaagg   1800
 gaacatggtg accagctacc acagagccca agtggctgcg agtaccttca tggaagttga   1860
 tgaacgccag ccgccttgcc cggagccacc cgccttgaag caaccccaac cgaaagacgg   1920
 accatgacga gctcttagct tgggatgggc gcaagagaac cttcaaggaa ggcatgaagc   1980
 caagcccctt gcagttgccg ttccacccgc cccctctggg gcttgcctgt ggcttcttgt   2040
 tgccctcctc tgtgggcggc agggaccttt gtgggggctt cgtgccttgc ttcttggggg   2100
 cccagggcgg ggcttggttc cacattccca ggcccccaac agccttcaaa gatgggttaa   2160
 gggagcttgc cctccctggg cccccccacc ttggtgactc gccccaccac ccccagccct   2220
 gtccctgcca cccctcctag tgggggactt agtgaattga tttgaccttg ttgaccttca   2280
 atacaattaa atgttgatcc cccacccaaa aaaaaaa                            2317



      <210> 402
      <211> 3587
      <212> DNA
      <213> Homo sapiens


      <400> 402
 tttcgtggaa ggttcgggag gcttctggaa aaagcgccgc gcgctgggcg ggcccgtcgc     60
 tatataaggc aggcgcgggg gtggcgcgtc agttgcttca gcgtcccggt gtggctgtgc    120
 cgttgggtcc tgtgcggtgc acttagccta gacgcctgag gaaacccaga cccactacca    180
 accgacggag gaggaggagg gtgagaactt tcgcctttca ggcaggaaat tgcccagttg    240
 atgtcattga tcatcaatac tttctaactc gaaacaaaga gatctttcct gagagagctc    300
 cttttcaaat tcatcagatg cattgggaca aaatcccagt attgaacgct tgacacgatc    360
 cccattcaat tagacctctg ggaaaagagc ttgcatattt aaccttatta cccgaaccaa    420
 acaagatccg aactcttcac tatttgtggg atacctggga ttgggaattg acccaaggct    480
 ggacttgatc aattaacctt ggtaactatc gcccaagtcc tggggaccaa agcggttcat    540
 gggaagcttt tgccaggctg gtgccagata ttcttctatg atttggccca gttccggtgt    600
 tggtttttat tcctgcttaa tttggttgca tgagaaagta acttgtgatc acccaaacat    660
 aacgatgatg agcagtacgc ttggggagtc ctcagcaggg gggatcattc acagtgagga    720
 cagacacagg gtgaacctat gggtccgttg gaacaaaagt tattcctaca cctggaaaga    780
 agaccaaact tgagtacttg gagggaacga agaataaaag gagattgtga aagaaacatt    840
 ctccagtttt attgggatat cccattactc ctttttgtgg agaaaggaac gtgataaaga    900
 agtaagcgat gatgaggctg aagaaaagga atgccaaata agaaaggaaa agagaagaga    960
 agacgaaaga gtcggaaagc ccaacccttg aaatggaagt atgttggttt tgatgaggaa   1020
 gaaagaaaag aaggatgtgt gtcaagagga agaagagaag gattaaggaa aagtccatcg   1080
 atcaagaaga gttcaccaaa acaaagccca tctggaccaa gaaatcccga cgatattact   1140
 aatgaggagt acggagaatt ctataagagc ttgaccaatg actggggaag atcactttgc   1200
 agtgaagcat ttttcagttt gaaggacagt tgggaattca gagcccttct attttttccc   1260
 acggacgtgc tccttttgat ctgttttgaa aacagaaacg aaaaagaaca atatccaaat   1320
 tgtaatgtac gcagaagttt ttcatcattg gataacctgt gaggagccta atcccctgaa   1380
 tatcctgaac ttcattagag gggtgggtag actccggagg atctcccctc taaaacatat   1440
 ccccgtgaga tgttgcaaca aaagccaaaa ttttgaaagt tatccaggaa gaatttgggt   1500
 ccaaaaaatg cttagaactc tttacttgaa ctggcggaag ataaagagaa ctacaacgaa   1560
 attctattga gcagttctct taaaaacctt aaagccttgg aataccacga agactcttca   1620
 aaatcggaaa gaagcttttc cagagctgtt aaggtactta cacatctggc ctctggtgat   1680
 gagatggttt ctctcaagga cttactgcac ccagaatgaa gggagaacca gaaacatatc   1740
 tattatatca catggtgaga ccaagtacca ggttagctaa ctcaagcctt ttgtgggaac   1800
 gttctttcgg gaaacatggg cttagaaagt gatctatatg attgagccca ttgatgagta   1860
 ctgtgtccca cagctggaag gaattttgag gggaagactt tagttgtcag tcaccaaaga   1920
 agggcctggg aacttccaga ggatgaagaa gagaaaaagg aagcaggaag agaaaaaaac   1980
 aaagtttgag aacctctgca aaatcatgaa agacatattg gagaaaaaaa gttgaaaagg   2040
 tggttgtgtc aaaccagatt ggttgacatc tccatgcctg tatttgtcac aagcacatat   2100
 tggctggaca gcaaacatgg gagagaattc atggaaagct tcaagccctt aaggagacaa   2160
 cttcaacaat ggggtttaca tggccagcca aaggaaacac cgggggatta aacccttgac   2220
 cctttccatt attgagacct taaggcaaaa ggcagaaggc ttgataagaa cgacaagtct   2280
 gtggaaggga tcttggtcat cttgctttat ggaaactgcg ctcctgtctt ctggcttcca   2340
 gtcttggaag attcccagac accatgctta acaggtttct tacaggatga tcaaactttg   2400
 gtctgggtat tgatgaagat gaccctacct gctgatgatt accagtgctg ctggtaactg   2460
 atggaaaatg ccaccccctt gaaaggagat gacgacacat tcacgcatgg gaaggaagta   2520
 ggacttattc tcttgggctt gaggggatgg actttacctg ttcagtactc tacaattcct   2580
 ctgataatat atttttccaa ggatgttttc ctttattttt ggttaatatt taaaaagtct   2640
 gtatggccat gacaactact ttaaggggaa agataagatt tctgtctact aaagtgatgc   2700
 tgtgataccc ttaggccact aaagccagag ctaagtaaat gctttttgga gtttccatgg   2760
 ttgggtttat tttccacgag attgggggta accgtgccac tgtaaaggcc cgtatgttaa   2820
 ccatggatgt taacctttgg ggtggtccta aaagtgtttt agctggtcaa agcccggatg   2880
 ccctaaggta gacccaaaat cttggttatt gaaaagtgtt ctgagctgta tcttggatgt   2940
 ttagaaaaag taattcgtta ccatcttgta aggatcttac ttttcggaac ttttcattcc   3000
 ctggtaagtt gacaattcgt gcatgtacta agtcctccta gaaatagggt aaacctgaag   3060
 caacttggat ggaaggttcc tctccacagg ggcttggttt tcccaaagaa aaagtattgt   3120
 ttggaggagc caaagtttaa aagccctacc taagccatat cgtaaaagct gtttcaaaaa   3180
 ataactccag acccagtcct ggtggatgga aattgtagtg ctccgagtca cattctgcct   3240
 taaagttgta accaaatacg agatgagtta aaagatattg tgtgacagcg tcttatttag   3300
 ggggaaaggg gagtatctgg gatggcagtt agtgccaaaa tgtaaaacat gagggcgcta   3360
 gcaggagatg gttaaacact agctgctcca agggttgaca tggtcttccc agcatgtact   3420
 cagcaggtgt ggggtggagc acacgtaggc acagaaaaca ggaatgcaga caacatgcat   3480
 cccctgcgtc catgagttac atgtgttctc ttagtgtcca cgttgttttg atgttattca   3540
 tggaatacct tctgtgttaa atacagtcac ttaattcctt ggcctta                 3587



      <210> 403
      <211> 1631
      <212> DNA
      <213> Homo sapiens


      <400> 403
 tttcgtccgg gatggtgagt ttcagagtta ggggtattgc agtgggggtc ctgggctgag     60
 gctggggccc aattccgagc actgacgtta ctgtcttgtc cccacagaag ccgatcctac    120
 tgcatgggcc atgagcggtc cattacgcaa gattaagtat aaccgcgaag gagacctcct    180
 ctttactgtg gccaaaggac ccctatcgtc aatgtatggt actctgtgaa tggtgagagg    240
 ctgggcaccc tacatgggcc ataccggagc ctgtgtggtg tgtggacgcc tgacctggga    300
 caccaagcat gtcctcacgt ggctcagctt gacaacagct gtccgtctct gggactgtgg    360
 aaacagggaa aagcagctgg gcccttttca aagaccaatt cggcttttcc ggacctggcg    420
 gttttgactt ttggggggca acattcatca tgttctccaa cggacaaagc agatggggct    480
 accagtgctt tgtggagctt ttttggacct ggcgggattc cgaggccaga tttgacaaca    540
 aatgagcccc tacatggaag attcccttgc aatgactcta aaaatcacca gtgctggttt    600
 ggggaccccc tgggggaggt gcatcatcgc tgggccatgg agagtgggag agctcaacca    660
 gtatagtgcc aagtcctgga gaggtgttgg gtgaatgtta aggagcactc ccgggcagat    720
 tcaacgacat tccagtttat tccaggggac atggaccatg ttttgttgac ccgcgttcca    780
 agggacaaca caggccaagc ttttttgatt ccacaacttc tggaacatca gaaaggcttt    840
 cggggacaag acggcctggc caactcaagc tggccctctc ccccaactaa tgacaaaggt    900
 ggttttgggc gggtggtcag gaaagccatt ggatgttaac cacaaccttc cacccaggga    960
 tttggcaagt tttagggcca ggtttctttc cattttggcc ttttggaaga agagtttgga   1020
 aagagtccaa gggtcacttt tggacctatc aacagtgttg ccttcccatc ctgatgggca   1080
 agagctacag caagcggcgg gcgagagatg gtttacgtcc ccgatccatt tactttcgac   1140
 cccaccagta cttcgaaatt tgaagtttga ggctttaaga aagctgggat ctcctggccg   1200
 ggccgttggt ggcctcatgc cctgtaatcc cccacccact tttttttttt aaggcaggcg   1260
 ggatcaccct gaggtcagga gtttaagacc cagccctgac ccaacatggg agaaaccctc   1320
 gtctcctact aaaaatacta caaaaataca aaaattaggc cagggcatgg gttggcacac   1380
 gccctatagt ccccagctac ttcagggagg ctgaggcagg agaatcactt tgaaccccag   1440
 gaggcagaag gttgcagtga gctgagatca cgtcattgca ctccatcctg agccacaaga   1500
 gcaaaactcc gtctcaaaaa aaaaaaaaag aagaaggtgg atctccaacc aggccagaga   1560
 agattctcac agaaggtttt gaactctaag aaataaattg gttactgtaa taaatggctt   1620
 ctggtcagat a                                                        1631



      <210> 404
      <211> 1631
      <212> DNA
      <213> Homo sapiens


      <400> 404
 tttcgtccgg gatggtgagt ttcagagtta ggggtattgc agtgggggtc ctgggctgag     60
 gctggggccc aattccgagc actgacgtta ctgtcttgtc cccacagaag ccgatcctac    120
 tgcatgggcc atgagcggtc cattacgcaa gattaagtat aaccgcgaag gagacctcct    180
 ctttactgtg gccaaaggac ccctatcgtc aatgtatggt actctgtgaa tggtgagagg    240
 ctgggcaccc tacatgggcc ataccggagc ctgtgtggtg tgtggacgcc tgacctggga    300
 caccaagcat gtcctcacgt ggctcagctt gacaacagct gtccgtctct gggactgtgg    360
 aaacagggaa aagcagctgg gcccttttca aagaccaatt cggcttttcc ggacctggcg    420
 gttttgactt ttggggggca acattcatca tgttctccaa cggacaaagc agatggggct    480
 accagtgctt tgtggagctt ttttggacct ggcgggattc cgaggccaga tttgacaaca    540
 aatgagcccc tacatggaag attcccttgc aatgactcta aaaatcacca gtgctggttt    600
 ggggaccccc tgggggaggt gcatcatcgc tgggccatgg agagtgggag agctcaacca    660
 gtatagtgcc aagtcctgga gaggtgttgg gtgaatgtta aggagcactc ccgggcagat    720
 tcaacgacat tccagtttat tccaggggac atggaccatg ttttgttgac ccgcgttcca    780
 agggacaaca caggccaagc ttttttgatt ccacaacttc tggaacatca gaaaggcttt    840
 cggggacaag acggcctggc caactcaagc tggccctctc ccccaactaa tgacaaaggt    900
 ggttttgggc gggtggtcag gaaagccatt ggatgttaac cacaaccttc cacccaggga    960
 tttggcaagt tttagggcca ggtttctttc cattttggcc ttttggaaga agagtttgga   1020
 aagagtccaa gggtcacttt tggacctatc aacagtgttg ccttcccatc ctgatgggca   1080
 agagctacag caagcggcgg gcgagagatg gtttacgtcc ccgatccatt tactttcgac   1140
 cccaccagta cttcgaaatt tgaagtttga ggctttaaga aagctgggat ctcctggccg   1200
 ggccgttggt ggcctcatgc cctgtaatcc cccacccact tttttttttt aaggcaggcg   1260
 ggatcaccct gaggtcagga gtttaagacc cagccctgac ccaacatggg agaaaccctc   1320
 gtctcctact aaaaatacta caaaaataca aaaattaggc cagggcatgg gttggcacac   1380
 gccctatagt ccccagctac ttcagggagg ctgaggcagg agaatcactt tgaaccccag   1440
 gaggcagaag gttgcagtga gctgagatca cgtcattgca ctccatcctg agccacaaga   1500
 gcaaaactcc gtctcaaaaa aaaaaaaaag aagaaggtgg atctccaacc aggccagaga   1560
 agattctcac agaaggtttt gaactctaag aaataaattg gttactgtaa taaatggctt   1620
 ctggtcagat a                                                        1631



      <210> 405
      <211> 2304
      <212> DNA
      <213> Homo sapiens


      <400> 405
 gacctttcct ctgggaagcc tgctcctcgg gccactgcga accctctcta ctctccgaag     60
 ggaattgtcc ttcctggctt ccactacttc cacccctgaa tgcacaggca gcccggccca    120
 agtctcccac tagggatgca gatggattcg gtgtgaaggg ctggctgctg ttgcctccgg    180
 ctcttgaaag tcaagttcag aggcgtgcac agactccaga attggatggc atgatgatta    240
 ctctgctgct gtttgtgggc gctgctgctg acctgggaga gtgggcaggt cctgggggga    300
 cagaacggtc tcagacaatg agctccagga aatgtccaat cagggaagta agtacgtcaa    360
 tataggaaat ttcaaaatgc tgtctagcga gttgaaacac gatgatgact ctcatagaaa    420
 aaacaaacga agagcgcaag acacttgctt cagcaacctt aggaagaagc caagaaggaa    480
 ggaaagaggg atgcccttaa attgagacca gggggattca gagacaaagc tgaaaggagc    540
 tcccagggag tatgcaattg agaccatgat gggccctctg ggacaggagt gttaagccct    600
 gccttgaaaa cagaccttgc atgaagttct acggcacgcg ttctgcagaa agtggcttca    660
 ggcctggttg gccgcccagc cttgaggaag ttccttgaac caggagctcg cccttctact    720
 tctgggatga atgggtgacc cgcattcgac ttccttgctg gaggaacgac cggcaaaaag    780
 acgcacatgc tggatggtca tgcaggacca cttcagccgc gcgttccagc attcatagac    840
 gagctctttc cagggacagg tttctttcac ccgggaagcc ccagggatta ccttaccact    900
 aaccttgccc tttcagcctt gccccacccg gaggccttca cttcttcttt tcccaagtcc    960
 cgcattcgtc ccgcagcttt gatgcccctt ctctccgtac ggagcccctt gaactttcca   1020
 cggccatgtt ccagcccttc cttggagatg gattacacga ggcttcagca gggccatggg   1080
 acatccactt ccacagcccg gccttccagc acccgccaac agaattcata cggagaaggc   1140
 gacggatgac cgggactgct gtgccgggga gatcccgcca caacttccac ggggctgcct   1200
 tgcggattga aggaccaagt ggtgacaaag tggccgggaa gatcttgttt tgtgggattg   1260
 tttccaccaa caaacccctc cccaggctaa agcttgcggg cggggagttc gaacggaatt   1320
 ccctccaggg ttcgattgag gagggtttga acaggggtaa ttacaaacgt agcttggtta   1380
 aaagttcctt aaccagttgg gaagatggtt caaacaactt tcttcctttg ttgggagcag   1440
 ctgaaacgag ccagttttaa ctgggtggtc acgggctggg caaaccctcc acgcaagggc   1500
 gaaagaccag ttacttatct ggcgggtcaa ccacgggtgg gctttcccac acttctgaac   1560
 ttcgggacgt tcccttcccg gtgtcaactg aaggtggtcc gtgaaagctc ttttgactcc   1620
 tgatccccca tcacttgtga cgggtccctt gttagaagtc tcccaggaaa gaacccccta   1680
 aaatttatgg aggaccgtgg gcggaggaaa gcgcttgcaa ggaatacccg caaaaaaagc   1740
 aaccggggga ggagttgaga tgttggattg ttgctttttg caccttacgg ggggcattct   1800
 gagtccagct cccccccaag atggagcttg cagccccccc agagagaagc tcttgcaacg   1860
 ttcaccaagt aacccaggcg cccatgcctc caggcccccg aactccgccg cgagcctctc   1920
 cccggctctg ggattcctgg caattttaac attcgatttt gctggttcat ggggaagaac   1980
 agaatttgct cctgcatggc aactaattca ataaaactgt ctttggtgag ctgatcgctt   2040
 ggagggtcct ctttttatgt tgagttgctg cttcccggca tgccttcatt ttgctatggg   2100
 gggcgggcag gggggatgga aaataagtag aaacaaaaaa gcagtggcta agatggtata   2160
 gggactgtca taccagtgaa gaataaaagg gtgaagaata aaagggataa gatgacaagg   2220
 ttgatccact tcaagaattg cttgctttca ggaagagaga tgtgtttcaa caagccaact   2280
 aaaatatatt gctgcaaatg gaaa                                          2304



      <210> 406
      <211> 2771
      <212> DNA
      <213> Homo sapiens


      <400> 406
 tttcgtgtcg ggggtccggg gcctgtcgcg gttgccaagc gctttttgct tggcgctggc     60
 gctggccaag gctcctttac tgttccagga tacagatctc ctgattcagg tgtccagtgc    120
 cttttgaact gaacgcaagc cctcctggac gattggaact gtaatgtgga aagggctctg    180
 atggagccag ttaaaatgct tcattatttg caaaatacca catacagtaa tacgatctgg    240
 atgtctttcc cctcctccac taagtagcat aagtgaagac ttcccagagg aagtgcgcct    300
 ttttcatctc gtatctgagt catggccaac agttgtttgc caaacaggaa cccgaggttt    360
 ttcacttcac tggttggatg ggaacaatag ggcatctgct aaagtttcag attccatttc    420
 tgctcagtat ccagtagtgg atcatgaatt tgatgcagtg gtggtaggcg ctggaggggc    480
 aggctttgcg agctgcgttt ggcctttccg aggcagagtt tgatacagca tgtgttacca    540
 agcgtgtttc ctaccagggt cacacacttg ttgcagcaca gggaggaatc aatgctgctc    600
 tggggaacat tggaggagga caacttggag gtggacattt tctaccgaac acccgtgaag    660
 ggtctccgac tggctggggg aaccaggaat gccaatccac ttacatgacg gagcaggccc    720
 ccgccgccgt ggtcgagcta gaaaattatg gcatgccgtt tagcagaact gaagatggga    780
 agatttatca gcgtgcattt ggtggacaga gcctcaagtt tggaaagggc aggcaggccc    840
 atcggtgctg ctgtgtggct gatcggaccg gccactcaat atttgcacac cttatatgga    900
 caggtctctg cgatatgata ccagctgttt tgtgggagta tttttgcctt ggatctcctg    960
 atagagaaca gggagtgccg tgggtgtcat tggcactgtg gcatagagga cgggtccatc   1020
 cattcacatt aagagcaaag aacactgttg tttgccacag gaggctacgg gcgcacctac   1080
 ttcagctgca cgtctgccca caccagcact ggcgacggca cggccataga tccaccaggg   1140
 gcaggccttc cttgccagga cctagagttt gttcagttcc accccacagg gatatattgg   1200
 tgctggttgt ctcattacgg aaggatgtcg tggagaggga ggcattctca ttaacagtca   1260
 aggcgaaagg tttatggagc gatacgcccc tgtcgcgaag gaccgtggcg tcttagagat   1320
 gtggtgtctc ggtccgatga ctctggagat cccgagaagg gaagaggctt ttggccctga   1380
 gaaagatcac gtctacctgc agctgcacca catacctcca gagcatctgg ccgcgcgcct   1440
 gcctggcatt tcagacacag ccatgatctt tggtggcgtg gatgtcacga aggagtcgat   1500
 ccctgtcctc ccctccgtac attacaacat gggcggcttt tccctcaact acaagaaaca   1560
 gatcttgagg cacgtgaatg gccaggatca gatttgttgc ccggcctgtt acgcctgttg   1620
 gggaggccgc ctgtgccttg ggtaacatgg tgccaaccgc cttcggggca aaactcgctc   1680
 ttagaactgg ttgtctttgg tcgggcatgt gccctgagca tcgaagagtc atgcaggcct   1740
 ggagagtgaa gtccctccaa ttaaaccaaa cgctggggaa gaatctgtca tgaatcttga   1800
 caaattgaga tttgctgatg gaagaagcat aagaacatcg gaactgcgac tcagcatgca   1860
 gaagtcaatg caaaatcatg cttgccgtgt tcccgtgtgg ggaagcgttg tttccaaaga   1920
 aggtttgtgg gaaaatcagc aagctctatg gagacctaaa gcacctgaag acgttcgacc   1980
 ggggaatggt ctggaacaca gaccttggtg gagacccctg gagctgcaga aacttattgc   2040
 tgtgtgcgct tcaagaccat tttacgaagc agaggcacgg aagggagtca cgggggcgcc   2100
 catgccaagg aaagactaca agggtgcggg attgatgagt acgataactc caaagcccat   2160
 tcagggggcc accggaagaa gcccttttga ggagccactg gaggaagcac acccctgtcc   2220
 ttatgtggaa cgttggccac tgggaagact cttcttttca tggtcaccct gggatataga   2280
 cccggtgatc gacaaaaact tttgaacgag ggctgactgt gccaccgtcc cggccagcca   2340
 tttcgctccc tactgttggg acaaggattc cggttgattg acagaatcag ctttttgtaa   2400
 attatgtata atagctcatg catgtgtccc atgtcataac tgtcttcata cgcttctgca   2460
 ctctggggga agaaggagta cattgaaggg agattgggca cctagtgggc tggggagctt   2520
 gccaggggac ccagtgggcc aggggagcgt gcgcacttta ccttttgtcc cctttgcttt   2580
 cattcttgtg agatgataaa actgggcaca gctcttaaat aaaatataaa tgaacaaact   2640
 ttcttttatt tccaaatcca tttgaaatat tttactgttg ggactttatg catatttgct   2700
 gacctaaaaa tcaaatgtag tctttgtgtt gtgttacatc aaaatccaga tattttgtat   2760
 agtttctttt t                                                        2771



      <210> 407
      <211> 2706
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2706)
      <223> n = a,t,c or g


      <400> 407
 gaaaagggga aaaaacccag acgactgaac tgcccacatt gacttacttg tcccagaggc     60
 gaaagtcaga agcaagggca cggttcatgc tctccgctgg gggagtatgg gggcaggcag    120
 gtgggcgagg gaagaggcag tgagtgtgga ggcgcggacg cgcggcggag ctggaactgc    180
 tgcagctgct gccgccgccg gagtgacctt tgatccccgt gctccggacg agcccgggcc    240
 tcgccatggc tgaccagctg actgaggagc agattgcagg agttcagcga ggcctcctcc    300
 ctctttgaca aggatgggag atggcactat tcaccaccaa gggagttggg gacaggtgat    360
 gagatccctg cgacagagcc ccactgacgc agagctgcag gatatgatca atgaggtgga    420
 tgcagatgac cttccaggga acgggaccat tgacttcccg gagttcctgg accatgaatg    480
 gccaggaaag atgaaaggac ccagacagtg aggaaggaga tccgagaagg ccgttccgtg    540
 tcattttgac caggatggga atggcttaca atcaagcgcc gcagagctgc gttcacgtaa    600
 ttgacgaacc tgggggagaa gcttgaccga ttgaggaggt gggatgagat gatcagggaa    660
 ggctgacatc gatggagatg gccaggtcaa ttattgaaga gttttgtaca gatgatgact    720
 gcaaactgga cagccccccg ggcgccctgc gatgcccgct ctctcgatct ctctcttcct    780
 cgcgcgcgca ctctctcttc aacactcccc agcgtacccc ggttctagca aacaccaatt    840
 gattgactga ggaatctgat aaagcaacaa aagatttgtc ccaagctgca tgattgctct    900
 ttctccttca tccctgagtc tctctccatg ccccttcatc tcttcctttt gccctcgcct    960
 ctttccatcc atgttctttc caagggcctg atggcattca taaagttgaa gccctcccca   1020
 gatccccttg gggaggcctc ttgccttcct ccagcccgga tgggctctgc ctccattttg   1080
 gtttgtttcc tcttgtttgt catcttattt tgggtgctgg ggtggctgcc agccctgtcc   1140
 cgggacctgc tgggagggac aaggaggccc tcccccaggc agaagagcat gccctttgcc   1200
 gttgcatgca accagccctg tgattccacg tgcagatccc agcagcctgt tggggcaggg   1260
 gtgccaagag aggcattcca gaagggactg agggggcgtt gaggaattgt ggcgttgact   1320
 ggatgtggcc caggaggggg tcgagggggc caactcacag aaggggactg acagtgggca   1380
 acactcacat cccactgggc tgctgttctg aaaccatctt gattggcttt ctgaggtttg   1440
 gctggggtgg gggacttgct cattttgggc cactctgcaa gattggactt gcccgcgttc   1500
 ctgaagcgct ctcgagctgt tctgtaaata cctggtgcta acatcccatg ccgctccctc   1560
 ctcacgatgc acccagcccg cctgagggcc cgtcctagga atggatgtgg ggatggtcgc   1620
 tttgtaatgt gctggttctc tttttttttt tttcccctct atgggccctt aagactttca   1680
 ttttgttcag aaccatgctg gggctagcta aaagggtggg ggagagggga agatgggggc   1740
 cccaccacgg ttttcaagga ggaacggcac ctggcaataa aaacagtctt gtcggccaag   1800
 ctgcccaagg ggaccggcag ctacagcaag ccctctgcgt tcctggtccg ccaagcacct   1860
 cccggcttct ccgtggtgac ttgggcgccg cttcctcaca tctgtgctcc gttgccctct   1920
 ttccctgcct cttccctcgc ccacctggnc tgccccgcat actcccccag cggagagcat   1980
 tatccgtgcc cttgcttctg actttcgcct ctgggaacaa gtaaagtcaa tgtgggcaag   2040
 ttcaagtccg tctgggtttt ttcccccttt tctgttcatt tcatctgggc tcccccccac   2100
 ccacctcccc accccacccc ccaccccctg cttccccctc actgccccag gtcgatcaaa   2160
 gtggcttttc cctgggaccc tgcccagctt tgagaatctc ttcctcatcc caccctctgg   2220
 cacccaagcc tctgaaggga aggaagggat ggggcatagt gggagaccca gccaagaagc   2280
 tgagggtaag ggcaggtagg cgtgaggctg tggacatttt cggaaatgtt ttgggtttgg   2340
 ttttttttaa aaccggggca atattgtgtt cagttcaagc tgtgaagaaa aatattatat   2400
 caatgttttc caataaaata cagtgactac ctgnnnnnnn nnnnnnnnnn nnnnnnnnnn   2460
 ntataagggg gggccctttt aaaaaaaccc ttggggggcc aaaatttacc nnnnnnnnnn   2520
 aaggtaaaat ttttttcttt aaggggggcc aattaaaacc ccccttggga tttttggaaa   2580
 aaaacctttt ttttgggggg ggaaaaaatg ggcccacccc cccaaaaaaa tttaaggctt   2640
 taagggnnnn nnnnnntttt taaggggaaa agggggaaaa acaacctgat tttctttgtt   2700
 tttaaa                                                              2706



      <210> 408
      <211> 1715
      <212> DNA
      <213> Homo sapiens


      <400> 408
 ctttcgtgga agaaggaaga agagggtaga ggaggagagg gaggaggagg agggaggtgg     60
 cggccccgcg gcggaggtat catgagcagg agggggatgg agaggacaac gctcctgggt    120
 ggcatggcgc tcctgctcct ccaggcgctg cccagcccct tgtcagccag ggctgaaccc    180
 ccgcaggata aggaagcctg tgtgggtacc aacaatcaaa gctacatctg tgacacagga    240
 cactgctgcg gacagtctca gtgctgcaac tactactatg aactctggcg gttctggctg    300
 gcgtggacca tcatcatcat cctgagctgc tgctgtgttc gccaccaccg acgagccaag    360
 caccgccttc aggcccagcc acggctacat gaaatcaacc tgatcgctta ccgagaagcc    420
 cacaattact cagcgctgcc attttatttc aggtttttgc caaactattt actacctcct    480
 tatgaggaag gggtgaaccg aactccaact cctcccccac catacagtgc ctttcagcta    540
 cagcagcagc agctgctgcc tccacagtgt ggccctgcag gtggcagtcc cccgggcatc    600
 gatcccacca ggggatccca gggggcacag agcagcccct tgtctgagcc cagcagaagc    660
 agcacaagac ccccaagcat cgctgaccct gatccctctg acctaccagt tgaccgagca    720
 gccaccaaag ccccagggat ggagcccagt ggctctgtgg ctggcctggg ggagctggac    780
 ccgggggcct tcctggacaa agatgcagaa tgtagggagg agctgctgaa agatgacagc    840
 tctgaacacg gcgcacccga cagcaaagag aagacgcctg ggagacatcg ccgcttcaca    900
 ggtgactcgg gcattgaagt gtgtgtgtgc aaccggggcc accatgacga tgacctcaaa    960
 gagttcaaca cactcatcga tgatgctctg gatgggcccc tggacttctg cgacagctgc   1020
 catgtgcggc cccctggtga tgaggaggaa ggcctctgtc agccctctga ggagcaggct   1080
 cgagagcctg ggcacccgca cctgccacgg ccgcccgcat gcctgctgct gaacaccatc   1140
 aacgagcagg actctcccaa ctcccagagc agcagctccc ccagctagag caggtcctgc   1200
 cagcacccag caacttggca aagcaaccac ggtaggggag aaccacgaga gaagcattaa   1260
 gtgactttca aagactttca gagtacagcc acttggttcc tttttgtttg ttttccttct   1320
 cctctcctgc attttcctcc atctccaggt acagttcggg gtgtggatgc ctcttcctcc   1380
 acaagggcac agtgttgtgg agggctaagt tggttctgtg actcattcct cataccctaa   1440
 ctccatctcc tttctttaaa gtcaaatctc acctaccctg tttgggtcag agagatgtgt   1500
 tttaaaagcc cccaaggaag gaggctggga ctgtgccctg acatgattct tggtgatgga   1560
 ataggtttgt gctctgattc tagtttaaga gaacgttgct gtatctcagt ccaggagagg   1620
 cagcccatct tggccctgga tgaagaagga aacccacaga ggcccagggc ttgtcattgt   1680
 gctgccagtg tctgccaagc cagcattgag ctaat                              1715



      <210> 409
      <211> 1587
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1587)
      <223> n = a,t,c or g


      <400> 409
 atcccccccc ccccatgctg ggcgagagag agccgccgcg ccggagcctc cttctttcct     60
 gcctctgatt ccgggctgtc atggcgaccc ccaacaatct gacccccacc aactgcagct    120
 ggtggcccat ctccgcgctg gagagcgatg cggccaagcc agcggaggcc cccgacgctc    180
 ccgatggcgg ccagccccgc ccattggccc agggagagcc tggttctgta ccactggacc    240
 cagtccttca gctcgcaaaa ggtgcggctg gtgatcgccg agaagggcct ggtgtgcgag    300
 gagcgggacg tgagcctgcc acagagcgag cacaatggat gccctggttc atgcggctca    360
 acctggggcg aggaggttgc ccgttcattc attccaccgc gacaacatca ttcagtgatt    420
 attgaaccag ttcatttgac tatgtgggag cgcacctttc acagggagag gcacgtggtg    480
 gccctgatgc ccgaggtggg cagccgtgca gcacgcacgg gtgctgcagt acccgggagc    540
 tgctggacgc actgcccatg gatgcctaca cgcatggctg catcctgcat cccgagctca    600
 ccaccgactc catgatcccc aagtacgcca cggccgagat ccgcaggaca tctagcccaa    660
 tgccaccacg gacctcatga aactggacca tgaagaggag ccccagctct ccgagcccta    720
 cctttctaaa caaaagaagc tcatggccaa gatcttggga gcatgatgat gtgagctacc    780
 tgaagaagat tctcggggaa ctggccatgg tgctggacca gattgaaggc ggagctggaa    840
 gaaagaggaa gctggagaac gaggggcaga aatgcgagct gtggctctgt ggctgtgccc    900
 ttaaaccctc gctgaatgtc cctccctggg agccacccct gnaccgccct naagttcctg    960
 ggactgtccc aagaaatact gggaaagatg gcagccggcc ccaacctgca gtccttcttt   1020
 gagagggtcc cagagacgct ttgccttccg gaaagtccct gggtgacatc cacaccaccc   1080
 tgctgtcggc cgtcatcccc aatgctttcc cggctggtca agaggaaacc cccatccttc   1140
 ttcggggcgt ccttcctcat gggctccctt gggtgggatg ggctactttg ccctacatgg   1200
 tacctcaaga aaaaaataca tctagggcca ggcctggggc ttggtgtctg actgtcggtg   1260
 tctctgtgct gtgtgattcc ccgtgagctc tcagtaactc actgtctcat gaacacttgg   1320
 acagccctcc ccgcccttcg ttctgagtaa taataccgtc agtgtgaaaa cattccgtag   1380
 tttagaagta gacgttgcaa atgctgtgac tcaaggccac gggctcttgc taaaagagag   1440
 agaggaagcg agagagagag agaaaaaaca aaaaaccaga aaaccacgaa ttgccttttt   1500
 ctatccgatt tcaaagggtc ctccaagatg ggaacttgtg gaagacttgg tttaaggaat   1560
 cttgaagggg aactcnttcc acaggga                                       1587



      <210> 410
      <211> 1682
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1682)
      <223> n = a,t,c or g


      <400> 410
 cgctgcggcg gtgggaaatg ctggcgcgcg cggcgcgggg cactggggcc cttttgctga     60
 gggtgagagc gaggcaacct ttccagaggg tcaggacaga gattacctgg gttctccgct    120
 ggaaaagagc gaaattccaa cttttggaga ggactggggt cagaggtcat ggtccccatg    180
 tgattctcca gaggatccta gagggtcgtg gtttatggag atgccttcag gaccgagggg    240
 cggcgtgtct ggccagatgg gatctctgct caccctcttc tttccttcag ggctctctac    300
 tggcttctgg ccgcgctccg cgccgcgcct cctctggatt gccccgaaac accgtggtac    360
 tgttcgtgcc gcagcaggag gcctggggtg gtggagcgaa tgggccgatt ccaccggatc    420
 ctgggagcct ggttttgaac atcctcatcc ctgtgttaga ccggatccga tattgttgca    480
 gagtcttcaa aggaaatttg ttcattcaac gttgccttga gcaattcggc tgtgactctc    540
 gacaatgtaa actctgcaaa tcgatgggag tcctttaccg tgcgcatcat gggaccctta    600
 caagggcaag cctacaggtg tggaggaccc tggagtattg ccgtcaccca gcctagctca    660
 accaaccatg tggatcagag cctcggcaaa ttctctttgg gacaaagtct ttccgggaac    720
 gggagtccct gaatgccagc attgtgggat gccatcaacc aagctgcttg actgctgcgg    780
 gtatccgctg cctccgttat gagatcaagg aatatccatg tgcccacccc gggtgaaaga    840
 ggtctaagca agnatgcacg gtggaggcca gacgggcggg aaacgggcca caggttctag    900
 agtctgaggg ggacccgacg aagtcggcca gtcaactgtg gcaagaaggg aagaaacagg    960
 ccccagatcc ctggcctccg aagcagaaaa ggcttgaaca gataaattca gggcagcagg   1020
 agagggccag ttgcagttct ggcgaaaggc caaggccaaa gttgctgaag gcaattcgat   1080
 ttcgtgggct gcaagctttg gaccccaaac ataattggga gattgcagca gctttcactt   1140
 gacttgttgg ccgaagcagt tatgttcagc ggcgtttttc caaaacttgg gccaaggaat   1200
 tcccaaaaca ctatccctac tgccctccca acccctggcg atgtcaccca gcatggtggc   1260
 tgcaggccca tgggtgtaat atggagccct cacccaaagc cccagtccca gtgccaggga   1320
 cttccagact cactcttcca gtgggagcag cagagatgtc ccagggtaca gatgcaagtc   1380
 cttgatgagg gaacttgatt cgagtcaaga tgagttagtg ggagctgggc ttggccaggg   1440
 aattctgggg accaaggaag cagattttcc tgattcgggc tctagcttcc ctgccacgat   1500
 ttgggtttgt atttttttgt ttgaccgtat aatcgtataa taaactccac cagtggcaaa   1560
 ccagaaactg tcctctttga ttggggaatg aagttgggaa agtcactagc attttccttg   1620
 gatccagtcc tgtcagcatg atgcctccat gaataagagt gaacttcttg taaagtgaaa   1680
 aa                                                                  1682



      <210> 411
      <211> 1237
      <212> DNA
      <213> Homo sapiens


      <400> 411
 gcgacaggga gggaggaagc ctaggagtcc gccgcgggac ggaggcctgg gggaactggg     60
 agttcagctt tctgcagagg gccactagga acctcggatt gcccacggaa gccagccact    120
 ttctttgaca gtccagccca cctcctcttc tgcccggaga agctccaggg gctgcctttg    180
 tgatcacagc atcttcacaa ggaccaaagg aaaataagat ttctcgtaag aacaccgtga    240
 ccacatcttt aaaattgacc catttcgtgg ctcccacaag atttacacct ccacactgag    300
 gccggaagtg gtttttgccc ctattaaaac atgggcgaaa agctttcttg tctccaagga    360
 aacgccacgt aatgagtcaa agctgtggcg cacgcgcaga agtacaagct accggaagtg    420
 atggcgcccc tactaaagcc ttggggttag tacgcgtgcg cagcagtctc ttccgacagt    480
 tgtgttgtgc caatggtgtt ataagaaaac ttcggttcgc tcccaggacc ccgggcagcg    540
 gcgggtgctg gaccgggctg cccggcagcg tcgcatcaac cggcagctgg aggcccatgg    600
 agaatgacaa cttccaggga tgacccccca cgcgggactc cctcagctcg gcaagagact    660
 gccttcagtt ttgatgacga tgcggacact gggaaagaaa aagaagaaaa cccgaaggtg    720
 atcattttta aacttcgctt cccgaaaaaa acttttcaag gccccttgtt ggaggagcaa    780
 gaacttgagt tttggccgag ggccttaact tacctgacgg ccttgtgcgg gaccccccat    840
 cgcgggcccc agcgcccctt ctgtgctgtc tgtggcttcc cccatccccc ctacacctgt    900
 gtcaagctgc ggtgcccggg tactgccact gtgcgctgtc tggggacccc accagggaga    960
 ccaggtgtct taaagtggac ctttgtaagc ctgggcattc ccagagagga agggccgctg   1020
 ttgcactgcc cggcctttca gaaagacaga attttcatca cccaattgca ggggggagct   1080
 ttttctggga ccaagggagg gagccgctca ttcacccaac aaaactgtgt cttatctgcc   1140
 aggaaagacc agcctcactc ctgggaactg tctggcaggt aggctgggcc cccacagtgc   1200
 tgttagaata aaaagcctcg tgccgaaaaa aaaaaaa                            1237



      <210> 412
      <211> 1319
      <212> DNA
      <213> Homo sapiens


      <400> 412
 cgacccacgc gtccgacgga gtccacacag gcagacttga ccttgaccac cagatagtct     60
 tcaagatggc caaactgggg cggaggcgca aaaatgtggg agcctgttaa aagacccgtc    120
 taccatggca gaggaaaatc cagtgcaatg gaaggatgtt tccacaagat cgtgtttcca    180
 ctgcattggc cttcaggaag gctcttgaca acacgacaag tcgcggctca tgatgtcgga    240
 gatctactgc aaggtgtgct atgggcgcag atatggcccc aaagggatcg ggtaattgac    300
 aaggcgcttg ctgtcttcag cacagacacg ggcggagcat ctcggcctgc agtttcaaca    360
 agtccccaaa ggccggcacg cttcagttac caccagcaac ccttccaaat tcactgcgaa    420
 gttttggaga gtccgagaag tgccctcgat gtggcaagtc agtctatgct gctgagaagg    480
 ttatgggagg tggcaagcct tggcaacaag accctgtttt ccgctgtgcc atctgtggga    540
 agagtctgga gtccacaaat gttcactgac aaagatgggg aactttattg caaagtttgc    600
 tatgccaaaa attttggccc ccacgggtat ttgggtttgg agggcttaca caacaagtgg    660
 aaaagaaaga atgaagaggt gcgccgtttc tcagattttt tgcgagccta aaacccttgc    720
 caagtaatcc tgcacagatc gatacccttt ccccaaatag cctctccttt gtagtcgtac    780
 attatgtgtt tctcctcaga agtgatcagg tctttactga atgttagaag aggcctttgg    840
 aagaaaatta tgtaaagttt aatctataac caaatgcttt attatttata atgcttggga    900
 atgggagaag caataaataa atgttttagt gctatcttgt atggctctag atcttttctt    960
 tgagatagaa attttcaaaa acataaagct agttcaaaaa acgagttgca gagcatataa   1020
 taaatttgga tgtcaactga gaaaggagtg agaaggaaga aataatgcgc aaaggaaagc   1080
 agtctttcag aatctgtcag ccaagtgtct ttctagttac tgctaatgga gaagaaaaca   1140
 gggggtctgg gagaaaatag agaacatgat agcaaaatct aaaaggaaaa tcaaaactaa   1200
 taaaattgct gaagagttga tccctttgtc ctatcgtggg gctttgtaat gttacacatc   1260
 tcgtgaaaac tcagaaatga caataaagcg tggcatttgc atctgtatta aaaaaaaaa    1319



      <210> 413
      <211> 1192
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1192)
      <223> n = a,t,c or g


      <400> 413
 cttgaccccg tgngatgata cccagtctga gggcgaccca cgcgtgcgcc gaccgcgagc     60
 cgtccaggtc tcagtgctgc gcccccccct gagcctagag gatgtttcat gggatcccag    120
 ccacgccggg cataggagcc cctgggaaca agccggagct gtatgaggtg agtggtgggt    180
 gcccacccgg ccggcattgg ccaacagcaa atgcctgtgt ggcctcacca gggtcctgca    240
 gcccctgttg gcactggccc acagagcccg ctctctccgg caggaagtga agttgtacaa    300
 gaacgcccgg gagagggaga agtacgacaa catggcagag ctgtttgcgg ttggtgaaga    360
 caatgcaagc cctgggagaa ggcctacatc aaggactgtg gtctccccca tgcgagtaca    420
 tctgcaggcc tgcatccacg gctcctgggt ccaattacaa agcttgcctt tcaggcaggt    480
 tcccaggggc ttcagaaatt cagctctatt gacgaattct gccgcaagtt tccgcctggg    540
 actttcccgc tggccaatgg agcggatcaa ggagggaccg gcccatcacc atcaaggacc    600
 gacaaggggc aaccttcaac ccgcttgcat cgcagacgtg ggtcttcgct ctttcatcac    660
 ggttcatgga caagcttgcg ccttggagat ccggccgcca atggatgaga tccagccccg    720
 aacctgcgga gagcctgatg ggagaaccca tgcaaccgca tgagcccacc ttcccaaccc    780
 gaactttgag ggccggccaa gacgggttca ccaagtggct gcagacccct gagcgggcaa    840
 tgtcgggcgt caagatgagc tgggacgact cacaggtgcg tccagatgct gttcgaccct    900
 ggagtcagcc tacaacgcct tcaaccgcct tcctgcatgc ctgagccctg gggcactagc    960
 ccttgcacag aagggcagag tctgaggcgg atggctcctg gtcccctgtc cgccacgcag   1020
 gccgtggtca tccagcacaa ctcactgtct gcagctgcct gtctggtgtc tgtctttggg   1080
 tgtcagaact ttgggggccg ggcccctccc cacaatacaa gatgctcgtc cgaccttcga   1140
 aaaaaaaaaa ttaaaattta aataaaaaaa gtcgtatcga tgtcgagcga tc           1192



      <210> 414
      <211> 1052
      <212> DNA
      <213> Homo sapiens


      <400> 414
 ggcacgagtc aaagacagag acaccaagaa gaatcggaac atacaggctt tgagatcaaa     60
 ggtttataaa gccaatatct gggaaagaga aaaccgtgag acttccagat cttctctggt    120
 gaagtgtgtt tcctgcaacg tttcacgaac atgaacatca aaggatcgcc atggaaagca    180
 gggtccctcc tgctgctgct gggtgttcaa acctgctcct gtgccagagc gtgggccccc    240
 ttggcccatc tgtcccggcg ggcttgtccc gatggccaag gtgacccttt cgagaccttg    300
 tttgaccggc gccgtcgtcc tgtcccacta catccatgaa cctctcctgc agaaatgttc    360
 aagcgaattc cgataaacgg tatacccaat ggccgggggt tcatttacca agggccatca    420
 acaagcttgc cacactttct tccctttgcc aaccccccga aagacaaggg agcaagcccc    480
 aacagatgaa ttcaaaaaga atttcctgag cctgatatat cagcatattg gcgatcctgg    540
 aatgagcctc tgtatcatct ggttcacgga agtacgtggt atgcaagaaa gcccccggag    600
 gctatcctat ccaaagctgt agaagattga gggagcaaaa ccaaaagggc ttccaagagg    660
 gccatggaag ctggatagtc aagcccaggt tcatccctga aaacccaaag aaaatgagat    720
 cctaccctgt ctgggtcggg gacttcccat cccctgcaga tggcttgatg aagagtctcg    780
 ccctttcctg ccttattata acctgctccg actgcctacg cagggatgtc acataagatc    840
 gacaattatc ctcaagctcc ctgaagtgcc cgaatcatcc acaacaacaa ctgctaagcc    900
 ccacatccat ttcatctatt tctgagaagg tccttaatga tccgttccat tgcaagcttc    960
 ttttagttgt atctcttttg aatccatgcg tgggtggtac agggtctcct cttaaaaaat   1020
 aaaaactgac tccttataga catcaaaatc ta                                 1052



      <210> 415
      <211> 1721
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1721)
      <223> n = a,t,c or g


      <400> 415
 agcggccgct atcgggaaga agaaatgact gtggtggagg aagcggatga tgacaaaaaa     60
 aggctgctgc agattattga cagagatggg gaagaggaag aggaagagga ggagccattg    120
 gatgaaagct cagtgaagaa aatgatcctc acatttgaaa agagatcata taaaaaccaa    180
 gaattgcgga ttaagtttcc agacaatcca gagaagttca tggaatccga gctggaccta    240
 aatgacatca ttcaggagat gcaccgtggt ggccaccatg ccagacctgt accaccttct    300
 ggtggagctt gaatgctgta cagtcgcttc tcggcttgct cggacacgat aatacagatg    360
 tgtccatagc ttgtggtcga ttttgcttca ggaattaaca gatatagaca ccctccatga    420
 gagtgaagag ggagcagaag tgctcatcga tgctctggtg gatgggcagg gtggtagcac    480
 tgctggtaca gaatctggag cgcctggatg agtctgtgaa agaggaggca gatggcgtcc    540
 acaacactct ggctattgtg gaaaacatgg ctgagttccg gcctgagatg tgtacagagg    600
 gtgcccagca gggtcttcta cagtggctgt tgaagagggc tgaaggcaaa gatgcctttt    660
 gatgccaaca aactgtattg cagtgaagtg ctggccatat tgctccagga caatgatgaa    720
 aacagggaat tgcttggggg agctggatgg aatcgatgtg cttcttcagc agttatccgt    780
 gtttaaaaga cacaatccca gcacggctga ggagcaggag atgatggaga atctgtttga    840
 ttccctctgc tcctgtctaa tgcttagttc caatcgtgag cgcttcctga agggcgaggg    900
 tcttcagctg atgaatctca tgctcaggga aaagaagatc tcccggagca gtgccctgga    960
 aagtgctggg accatgccat gattggcccc gaaggcacag acaactgcca ttaagtttgt   1020
 ttgacattct tggctttacg gaaccatctt tcccctcttt atgaaatctc ccaggaagat   1080
 caagaaagtg ggaaccactg agaaggaaca tgaagagcat gtctgttcga tcctggcttc   1140
 cctcctgcgg aacctgagag ggcagcagcg gacccggctt ctgaataaat tcactgaaaa   1200
 tgacagtgag aaggtggaca gactaatgga gttgcatttt aaatatctgg gtgcaatgca   1260
 ggtggcggac aagaagattg aaggggaaaa acacgacatg gtccggcgag gagagatcat   1320
 cgacaatgac accgaggagg agttctacct cccggcgcct ggatgcgggg ctctttgttt   1380
 ctcncaagca acatctgcta catcatggcc gagatctgca atgccaatgt cccccagatt   1440
 cgccagaggg ttcacccaga tccctaaaca tgcgaggaag ctccatcaaa attgtcaggc   1500
 atatcatcaa aggagtatgc agagaacact cgggggacgg ccggagcccg gagttcccgg   1560
 aagaacgagc aaaagcgcat cctgggcttg ctggagaact tctagaggca ccttgggccc   1620
 tgcgcatcat gggactctct cagcttccct cccaggatca gtttctacac aactctgtgt   1680
 ggcttttgga caaattaaag ctagttttgg taaaaaaaaa a                       1721



      <210> 416
      <211> 2058
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2058)
      <223> n = a,t,c or g


      <400> 416
 ttcctgcccg cgcggtgttc cgcattctgc aagcctccgg agcgcacgtc ggcagtcggc     60
 tcccatcgtt gaccgaatca ccgacctctc tccccagctg tatttccaaa atgtcgcttt    120
 ctaacaaggc tgacgctgga caagctggac cgttaaaggg aagcgggtcg ttatgagagt    180
 ccgacttcaa tgttcctatg aggagccacc cagataacaa accacccaga ggattaaggg    240
 ctgctgtccc aagcattcaa attcttgctt tggacaatgg gagccaagtc ggtagtcctt    300
 atgaggccac ctaggcccgg cctgatgggt gtgcccatgc ctggacaagt tactccttta    360
 gagccagttg cctggtagaa ctcaaatcct cttgcttggg caagggatgt tctgttcttg    420
 gaagggactg tgttagggcc cagaagtggg agaaaaggcc tgtggccaac ccagctagct    480
 gggtcttgtc atccttgctg gagaaacctc cggcttttca tgtggaggaa gaagggaagg    540
 gaaaagatgc ttctggggaa caaggtttaa agcctgagcc aggccaaaat agaagctttt    600
 ccgagctttc actttccaag ctaggggatg tctatgttca atgaatgctt tttggcactg    660
 cttcacagag cccacagctt ccaggtagga gtcaatctgc cacagaaggc tggtgggttt    720
 ttgatgaaga aggagctgaa ctactttgca aaggccttgg agagcccaga gcgacccttc    780
 ctggtccatc ctgggcggac gtaaaaagtt gcagacaaga ttccagctca tcaatgaatt    840
 atgctggaca aagtcaatga gatgattatt ggtggtggaa tggcttttac cttcctttaa    900
 ggtagctcaa caacatggag attggcactt ctctgtttga tgaagaggga gccaagattg    960
 tcaaagacct aatgttccaa agctgaaaaa gaatgggtgt gaagattacc ttgcctgttg   1020
 actttgtcac tgcttgacaa gttttgatga gaaatgccaa agactggcca agcccactgg   1080
 tggcttcttg gcatacctgc ttggcttgga tgggcctttg gactgtggtc ctggaaaggc   1140
 aggcaaggaa gtatgcttga gggcttgttc actcggggct aagcaggatt gtgtgggaat   1200
 gggtcctgtg ggggggtatt ttgaatgggg aagcttttgc ccgggggaac caaaagctct   1260
 catgggatga ggtgggtgaa agcanatcca attctagggg gcttgcattc accattcata   1320
 gggttggttg gagacacttg ccacttggct gttgcccaaa tgggaacacg ggaggataaa   1380
 agtccagcca tgttgagtca ctgggggggt ggtgcccagt ttggaagctc ctggggaagg   1440
 ttaaagtcct tacctggggg ttggattgct cttcagccaa tgtttagtat tttctttcct   1500
 gcccttttag gttcctgttg cacagccccc taaagtccaa ctttagcatt tttctgcaat   1560
 ctccaacttg gccattagcc taaaaccctt cccatgtcaa agattccagc ctaggtggcc   1620
 caaggagatg caagtgccca ggaacccctt aaacgagttg cgacagcatc ctcaagctca   1680
 tcattcactg caccctggga tttgcataca ttccttcaag atccccattt tgaatttttt   1740
 tagtgaccta aacccattgt gcattcctag agtgcatata tttatatttt gactcgtgct   1800
 ctaaaaagaa agtgaagcag tgttagctta ggttttctct tttgatgtag gttattatga   1860
 ttaagctttg tgccctgttt cactactcga gcatggaaac aagatgaaat tccatttgta   1920
 aggtagtgag acaaaatttg atgatccctt aagtaaacaa taaaagtgtc cattgaaacc   1980
 gtgnnnnnnn nnnnnnnnng ggggcggccg ttttaaagga tccttggggg ggcccaagtt   2040
 tacccgtgct tgcaactc                                                 2058



      <210> 417
      <211> 1531
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1531)
      <223> n = a,t,c or g


      <400> 417
 ccgggtcgac ccacgcgtcc gcagcagtcc aagctcagtc agcagaagag ataaaagcaa     60
 acaggtctgg gaggcagttc tgttgccact ctctctcctg tcaatgatgg atctcagaaa    120
 taccccagcc aaatctctgg acaagttcat tgaagactat ctcttgccag acacgtgttt    180
 ccgcatgcaa atcaaccatg ccattgacat catcctgtgg gttcctgaag agaaaggtgc    240
 ttccgaggta tctcctaccc atgtgtgtgt gtccaaggtg gtaaagggtg gctcctcagg    300
 caagggcacc accctcagag gccgatctga ccgctgacct tggttgtctt cctcagtcct    360
 ctcaccactt ttcaaggatc aagttaaatc gccggggaga agttcatcca aggaaattag    420
 ggagacagct ggaagcctgt caaagcgaga gtagcatttt ccgtgaagtt ttgaggtcca    480
 ggctccacgc tgggngcaac ccccgtgcgc tcagctttcg tactgagttc gctccagctc    540
 cggggaaggg ggttgagttc gatgtgctgc ctgcctttga tgccctgggg tcagttgact    600
 ggcggctata aacctaaccc ccaaatcttt tgttaagctc attcgaggag tgcaccgacc    660
 tgcagaaaga gggcgagttc tccacctgct tcacagaact aacagagagt cttcctgagg    720
 cagcgcccca ccaagctcaa gagcctcatc cgcctaagtc cagcactggt accaatattt    780
 ttaggaatga gccttgggaa tctgccaccc tcagtatgcc cctgtatcct ctgactttct    840
 tatgcttggt accctgtgga gcatgaaatc acatttcaac acagccccag ggattttcgg    900
 acggtcttgg aattagtcat aaactaccag caaattctgc atctacctga acaaagtata    960
 atgactttaa aaaaccccat tatttgaaaa gtacctgaga aggcagctca cgaaaaccca   1020
 gggcctgtga tcctggaccc ggcgggaccc ttacagggaa acttggggtg gtgggaggac   1080
 ccaaaggggt gggaggccag ctggccacaa gatggctgag gccctggctg aattacccat   1140
 gctttaagaa ttggggatng gtccccagtg aagctccctg gattctgcct ggtgagaccc   1200
 tcctgctttc cttccctgcc cattccatcc ctgcccctct ccatgaagcc ttgagacata   1260
 tagctggaga ccattctttc caaagaactt acctcttgcc attcatcccg gcccctttcc   1320
 atggaggttg aggacataaa gctgggggcc cttttttcca aagaacttcc cttttgccaa   1380
 aggcccttta ttttcatata gggacaggct gggccccatt ttttccagtc attttggtcc   1440
 caatcgaggg tttttggaat tttcccatcc cttgtccaga attccttccc ctaagggtaa   1500
 taataaataa tttttaaccc caaaaaaaaa a                                  1531



      <210> 418
      <211> 2066
      <212> DNA
      <213> Homo sapiens


      <400> 418
 tttcgtggcg aggggcgcgg cccggcgtgg gccgcagaga cgttggattt cggcgggggc     60
 tgtggactgg cctcggggcg acttgaggtg ttcctggcca gtgtccttcc acctgtccac    120
 aagcatgggg aatcatcttc tccatacctc ttcaagggcc tttttggcaa aaaaagaaat    180
 gcgcatcctc atggtcgggc ctgggatgct gcagggaaaa ccacgatctc tctacaagct    240
 taagctgggg tgagatcgtg caccaccatt cccaccatag gcttcaaccg tggaaacccg    300
 tggaagtaca agaacattca gctttcactg tgtggggacg tggggtgggc cagggacaag    360
 atcccggccc ctgtgggcgc cacttacttt ccagaacaca caaggccttg atctttcgtg    420
 gttgggacag caattgacag aagagcgtgt tgaacgaagg cccgttgagg agcttcattg    480
 agggttgctg ggcccaggac gaagctccgg ggatgctgtc ctcctgggtg tttcgccaaa    540
 aaaagcaggg acctccccaa cgccatgaat gcggccgaga atcacagaca agctggggct    600
 gcacctcact acgcccacag ggaactgggt acattcaagg ccacctgcgc caccagcggc    660
 gacgggctct tatggaaggg actggactgg ctgttccaat cagctcccgg aacccagaag    720
 tgaaccgcga ccccccctcc ctcttaactc tcttggcctc tgctttactt ctatgtgggc    780
 aacgtgccgg ctcgtggtgt gagtgccaga agcttggctt ccttggtcgg tcaccgtgtg    840
 catcgcaccg tgctgtaaat gtggcagcac gcagcctgcg gccaggcttt ttatttaatg    900
 taaatagttt ttgtttccaa tgaggcagtt tctggtactc ctatgcaata ttactcagct    960
 ttttttattg taaaaagaaa aatcaactca ctgttcagtg ctgagagggg atgtaggccc   1020
 atgggcgacc tggacctcca ggaagtcgct tgtgttggga gagccggccc acgcccttgg   1080
 ctttagagct gtgttggaaa tccattttgg gggctgggtt ttaacccaaa ctcagtgcat   1140
 tttttaaaat aggttaagaa atccaagtcc gagaacactt gtaacacaca gcaagggaga   1200
 cccccgccta gcataagatt ttgcagttta cggcctggga tgcccagtcg gccagcccca   1260
 gcttgtttcc cctcggggaa cattgaaggt gggtggtggc gcacacgacc tgcgactcaa   1320
 attctggcat ggtcaacagt agaagatccc cggcaactcc gcttgttcct tggggtcacc   1380
 ctggcatttc cattaggcca tgttgcttgt cccttgtgct tcccaacggt tccccagggg   1440
 gccaaggctg gggaagcccc cccagccacc ccacttttat gcccgcaggc cgcccttacc   1500
 ccaccttcaa ggcaagcctt atggggacgc aagggcccca tcttgttccc tcgggtcgcc   1560
 cgtgtggccc agaagttggg tcccgttcgt ccccccaaac aactcggtgc ctcgcctcaa   1620
 gaacactttt ggccagggat tgtctggggg ccctcaccca gccagggagc gccgtgcaaa   1680
 acccgggcca ggccggtcca acctagaccc caccagcccc ctcggggagc accccccacc   1740
 tcttgtgtgt gatggtagct ttctctcccc tcagccctgc caagggtccc gatttgccca   1800
 tcgaaaaaag acaaccttct actttttttc tttttgtatt tttgaataaa cactggaagc   1860
 tggagctgtt aaatttatct tggggaaaac ctcgagaact ggtctatttg ggtgttcgtg   1920
 ggaacctttt actgctttcg agatacacgg attagtaatc acactgtgtt gtatacttgt   1980
 tttcagtttt tcattttcga caaacaagca cctgtaactt actagctatt agaactaaaa   2040
 tctcttaact atttaaaaaa aaaaaa                                        2066



      <210> 419
      <211> 2006
      <212> DNA
      <213> Homo sapiens


      <400> 419
 aactgataca atgcatctga cacgccagct tggacgagga ccgagcttgg ctgtgtttat     60
 ctcgttgggg actaaggcgt cggttggcgc gcaacgggtt ctaggctgca ggcagctcga    120
 ggacaccgcg ggccccgccc cggctgcggg ctggcagcat agcataggca ggcaggccgt    180
 gccggggggg gcatgttgct gtaaccagtg gcccagggga tgttacggtg gacagcgcac    240
 ctggagggcg ggccccgcag ggtgaaacca tgctgctgtg gctggcgggc atcgggtata    300
 ctccttcggg gggtactgct ctggtgaaaa ctattagaca ctgcgtcaaa tagatgtgca    360
 cattttcaat gcagtgtcct tgcgttggac aaagctgccc cccggtgaag tctgccatcc    420
 gtgggcaagc tcctgtggta cccctacatg cgctatggac actcaacccg tcctcattcg    480
 acgacacagt cctcctttgg ggcgggcgga atgacacccg aaggggccct gcaatgtgct    540
 ctatgccttt gacgtcaata cgcacaagtg gttcacaacc ccgagttttc agggacagtt    600
 cctggggccc gggatggaca ttcagcctgt gtcctagggc aagatcatgt acattttttg    660
 ggggctacga gcagcaggcg aactgttttt ccaatgacat tcacaagcta gataccagca    720
 ccatgacatg gtactcttat ctgtacaaag ggcagccctg cacgctggag ggacttccac    780
 tcagccacaa tggctgggaa gtcacatgta tgtcttttgg ggggccgtgc cgtccgcttt    840
 gggccattcc attccaacaa tgagatttac ctgcaaccgc attcgagtct ttgacaccca    900
 gaactgaggc ttggctggga ctgtcccccc gactcccagt gctgccttga ggggcgcccg    960
 gaagccactt cggcctttgg gtaacaatgg gggagctgta catctttggg tggttattaa   1020
 tgcaaaggct ggaaccggca ctttccatga cctctgggaa gttttaatcc tgtgtccttt   1080
 acctgggaaa aagattgaac cgaaggggaa ggggccatgt ccccgccggc gccagtgctg   1140
 ctgtattggt ggtgacaaaa atgtcctctt ttgggggtac caagtccatc tcctgaggaa   1200
 ggccctggga gatgaatttg accttataga tcaatcttga cttacaattt ttgggagctg   1260
 ttagcgctag tctgaagact ctgtgcaaac tgggccgtga ttcagtatta acctagaacc   1320
 agtcctgttt tgcctcatga ttatcaggtt gggagctgaa tgcccatgac caccaacagc   1380
 aatatcagtc cgccccatcc gtctcctccc atgggtaagg aaggaagttt ctgccacctc   1440
 ccctcctgaa gcctgctgtc aatcttcact gcccctgccc atctgtcacc cacctgctcc   1500
 tttggacccc tgggactttg ggtataacct ccatgtggga gttgttgggc gagaggaggt   1560
 tctctgtggc tgtgaaattc agtgggggga gctgtagcgg gggtgggggc taggttcctc   1620
 cccccttggg ccgagggccc ttttcccctt gggtgctttt gttccccatc cacctccttt   1680
 caagctgctc cctgggcctc agctctgccc aagggccagc ccaggttctg ctgggaaaga   1740
 aaggggaatg gggagaaggg agaagcaagc agtgtctgag cctcaggagc ttccccctcc   1800
 ccctttgcct atcccctccc ctctgacttg agccttgagc cttgaactgg gagtctgaaa   1860
 ggagttgcag ctgttggcat gagacctcct tctccccgtc ttggggaggt ggggaccagc   1920
 agataaatcc cacccttcct tgagctgtcg ctgtactctg aagttcagcc agctcagatt   1980
 ttataaaaaa ataattaaaa tctcaa                                        2006



      <210> 420
      <211> 1049
      <212> DNA
      <213> Homo sapiens


      <400> 420
 aactgttcca ttttccgtat ctgcttcggg cttccacctc atttttttcg ctttgcccat     60
 tctgtttcag ccagtcgcca agaatcatga aagtcgccag tggcagcacc gccaccgccg    120
 ccgcgggccc cagctgcgcg cctgaaggcc ggcaagacag cgagcggtgc gtgcgaggtg    180
 gtgcgctgtc tgtactgagc agagcgtggg cattctcgcg ttgcgccggg ggcgccgggg    240
 cggcgcctgg ccttccctgc tggaacgaca acagggtaaa cgttgttgct ctacgacatt    300
 gaacggctgt taactcacgc ctcaaggagc tggtgcccac ccctgcccca agaacccgca    360
 agggtgagca agggtggaga tttctccaag cacgtcattc gacttacatt caggggacct    420
 ttcagttggg agctgaaact tcgggaatcc cgaagttggg aacccccggg gggccgaggg    480
 gctgccgggt ccggggctcc gctcaagcac cctcaacggc gagattcagc gcccctgacg    540
 gccgagggcg gccatgcgtt cctgcggacg atcgcatctt gtgtcgctga agcgcccttc    600
 ccccagggac ccggcggacc cccagcccat cccagggggg caaagaggaa ttaccgtgcc    660
 tctgtgggtc ttccccccaa cgcgcctcgc cggatctgca gggagaacaa agaccgaatc    720
 ggcggcccac tgcgccctta acgtgcagtc ccacgcctgg ggctgaggct gaggcactgg    780
 cgaggagagg gcgctcctct ttgcaccacc tacttagtca ccagagactt tagggggtgg    840
 gattcccact cgtggggttc tatttttttg aaaagcgaga cattttaaaa aatggtcacg    900
 tttggtgctt ctcagatttc tgaggaaatt gcattatgta tagtatatta caatgatcac    960
 ccgactgaaa aaatggtttt acaatagttc ttgttggggt ggtttttttg gtatttaacc   1020
 aaataattta gatggtgaaa aaaaaaaaa                                     1049



      <210> 421
      <211> 2052
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2052)
      <223> n = a,t,c or g


      <400> 421
 ctcgcgaggc cccagagagc aggcgctggg cagtgtggag gtcgttggag tcacttccgc     60
 gtcaccagct cctgtgcctg ctcagtcggt gcccctcccg ctccagccat gctctccgcc    120
 ctcgcccggg ccgtgccaag cgcctgctct ccgcccgcag cttcagcacc ctcggcccag    180
 aacaatgcta aagtagctgt gctaggggcc tctggaggca tcgggcagcc acttttcact    240
 tctcctgaag aacagcccct tgggtgagcc cgccttgacc ctctatggat attcgcgcac    300
 acaccccggg agttggcccg cagaatctgg agcccacatc ggaggaccaa aagccggctt    360
 gttgaaaggc ttacctcggg acctggaaca gcttggcctg gattggcctg gaaaggtttg    420
 ttgatgttgg taagtttatt tccgggttgg gagttcccca gaaaagccag ggcattgacc    480
 cgggaacgac ctgttcaaac aaccaatggc cacgattgtg ggcaaccctg gaccgctggc    540
 ctgttgccca gcattgcccg gaagccatga tctgcgtcat tgccaatccg gttaattcca    600
 ccatccccat cacagcagaa gttttcaaga aagcttgggg gcaacacccc caaaaaaaat    660
 cttcgggcgt gacgaccctg aacatcgtcg gagccggcac ctttgttgca gagctgaagg    720
 gtttggatcc agctcgagtc aacgtcccta tccactggtg gccatgctgg gaagacccat    780
 catcccccct gatctctcag gtgcacccca aaaggtggac tttcccccag gaccagcttg    840
 acagcactca ctgggccgga tccaagaagg ccggcacgaa ggtggtcaag gctaaagccg    900
 gagccaggcg tctgccaacc ctctcccaat gccgtaatgc cggcgccccg gctttgtctt    960
 ctccctttgt gggatgcaaa tgaattggaa aaggaaaggt gtttgtggaa atgttcccct   1020
 ccgttaaagt ccacaggaaa acggaatgta cccctacttc ctcccacacc cgctgcctgc   1080
 cttgggaaaa agggccatcg agaaaaaaaa ggnaaaaanc tctgggccat cggccaaagt   1140
 ctccttcttt ttgaggagaa agatgatcct cggatgcccc atcccccgag ctgaaggccc   1200
 tcccatcaag aatgggggaa gatttctgtg aagaccctga aagtgagccg ctgtgacggg   1260
 tggcccagtt tcccttattt tatgaaggcc atcatgtcga ctgcaaagcc gttgccagat   1320
 aaaactttgt attttaattt gctttggtga tgattacctg tattgacatc atcatgcctt   1380
 cccaaattgt gggtggggct ctgtgggcgg cctcaataaa agccgtcctt gattttattt   1440
 ttcaaggtcc cttctgtaaa tgctgtgctt tcttccctgt gagagccaac tttagagtgt   1500
 ctgctacctc ttcattacca atcagaatta ggatgatgtt taactgttag acttgaagcg   1560
 tgacgttttc atcagtagct ttcaaggaaa gtcttaaatt gttaatttta tgggaattgg   1620
 acacagtatt tcagttttac ccgtacatgc tcctcccgcc cctcctgttg ggcacccttg   1680
 catcgcccgg gcctgattcc tcctgggggg tagttcaccc ccacgggttc atagttcagc   1740
 gggcgaatgc aggggcaggc tgtttttctg ggctgaggca aacagcacct ttctcattga   1800
 gcttcctcta ctgacctctg tcccccttgg gatttcatct tctgaccgaa ccctgatgtt   1860
 cagtggcaga gacagcccat agccagaact gtgggtagac cagggttggg gtgtgcggtt   1920
 tggggacagc ccaaaccccc agccgctgtg tcaaggccta ggacgccatg ctgccatcaa   1980
 aagggggttc caggtttcca atcagtggcc taaagaaggg acttcttgtt gtactgagga   2040
 gtgcggnaat tt                                                       2052



      <210> 422
      <211> 2012
      <212> DNA
      <213> Homo sapiens


      <400> 422
 tggactcttt ggacaaccac aggtgccgag gggacctgac caagacctac agcctggagg     60
 cctatgacaa ctggttcaac tgcctgagca tgctggtggc cactgaggtg tgccgggtgg    120
 tgaagaagaa acaccggacc cgcatgttgg agttcttcat tgatgtggcc cgggagtgct    180
 tcaacatcgg gaacttcaac tccatgatgg ccatcatctc tggcatgaac ctcagtcctg    240
 tggcaaggct gaagaaaact tggtccaagg tcaagacagc caagtttgat gtcttggagc    300
 atcacatgga cccgtccagc aacttctgca actaccgtac agccctgcag ggggccacgc    360
 agaggtccca gatggccaac agcagccgtg aaaagatcgt catccctgtg ttcaacctct    420
 tcgttaagga catctacttc ctgccacaaa atccatacca accacctgcc caacgggcac    480
 attaacttta agaaattctg ggagatctcc agacagatcc atgagttcat gacatggaca    540
 caggtagagt gtcctttcga gaaggacaag aagattccag agttacctgc tcacggcgcc    600
 ccatcctaca gcgaggaagc tctcttcgtc gccctccttt gaaagtgagg gtcccgagaa    660
 ccacatggaa aaagacagct ggaagaccct caggaccacc cttctgaaca gagcctgagg    720
 cggatgcagc ccgcgacgcc agaggaagca cgtgcactaa ctgggtttaa attttgactg    780
 atgtgggttg agaatgagga gcccctcact ggttggggtc cattttgtat ataactttta    840
 tgagaaaaaa atggtaatta tttcacgcat caacctttgg cacttacaaa gttttttttg    900
 ttgtatttta aataacaggg caaggccctg ctttggggag ggggagggga gagtatcatg    960
 ggagatggta tccatgataa catcttattc taatgagatg tagagtatta ttttttactt   1020
 tttgattatt aacatcttat gaaaaaaata ttttaaaaaa cccagccaaa accaacgtga   1080
 gccctgcctg ctcggacgcc tttccagcca gtgtctctga cgtcggggtt agtgccttaa   1140
 agggtactgg gggtctggtc ttcctgctct gtggtttggg ctgcggtgag tcccactcca   1200
 cctgggcgcc tgccctcagg agcctgggct gcgaggctcc ataggagggc tggtggctgg   1260
 gaggtcgcgt ccgcacactt ctggaagtga gcctttgagt acgggctgtc caaagtttac   1320
 attttcattt tcctttcagg gatttgtggg gtcagggagg ggcagggggc acctggcagc   1380
 atattttctg tgacaatgtg tccagcaaat cattcttcaa ctacatttta gaaaggagga   1440
 aatctaaaat aaggttatgg agtggaagca tggagttgac agtcttctgg gctgtgactg   1500
 aaagacacac tgagctgtga tgaagaacaa tacatggccg actccacgga ggagacattt   1560
 agagctaggc ttgaaaccta tcatctacag aggggagggc agccatcagc cctcttccca   1620
 cctgggtagg cagcgcccta attggaattg gaaacagaaa attcgccagg ccatactgct   1680
 ggagcccatt cagataaaac tgcccaatac tgagaggtgt tttctacacc cagctagagg   1740
 agcacactcc atttttccat ggctgagatt ccggggggaa agccctgggc cttactgacc   1800
 atggcgcagg acagctgtcc ttcagaaagc acacggtcaa tccacgtgga ccgtctccct   1860
 cgcaggaact ccgcatcctt gtccctctct gcattcccag tttccgcagg agccttgatc   1920
 aatggggaag cctgggtgag gatgggccag gtcccaattc ccaaagctcc tggaagagcc   1980
 tgaagacatt gtgaaaggct gggcctgggg ag                                 2012



      <210> 423
      <211> 6351
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(6351)
      <223> n = a,t,c or g


      <400> 423
 ctgaagagga gctagaggcc tcaaagagct ttgggcctgg gaatgaagag gaggagaagg     60
 aggagaaaga atatgaagag gaggaggagg aggactatga cgaggaggag gaagagtcca    120
 gtgaagccgg gaaccagagg ctccagcagg tcatgcacgc ggcggatcct ctggagatcc    180
 aggctgacgt gcactggact catatccgtg agagagagga ggaagagagg atggcgccgg    240
 cctctgagtc ctctgcttcc ggagccccat tggatgagaa tgacctagag gaagatgtgg    300
 actcagaacc agccgagata gaaggggagg cagcagagga tggggaccca ggggacactg    360
 gtgctgagct ggatgatgat cagcactggt ctgacagccc gtcggatgct gacagagagc    420
 tgcgtttgcc gtgcccagct gagggggaag cagagctgga gctgagggtg tcggaagatg    480
 aggagaagct gcccgcctca ccgaagcacc aagagagagg tccctcccaa gccaccagcc    540
 ccatccggtc tccccaggaa tcagctcttc tgttcattcc agtccacagc ccctcaacag    600
 aggggcccca actcccacct gtccctgccg ccacccagga gaaatcacct gaggagcgcc    660
 ttttccctga gcctttgctc cccaaagaga agcccaaagc tgatgccccc tcggatctga    720
 aagctgtgca ctctcccatc cgatcacagc cagtgaccct gccagaagct aggactcctg    780
 tctcaccagg gagcccgcag ccccggccac ccgtggcggc ctccacgccc ccacccagcc    840
 cactccccat ctgctcccag ccccagcctt ccaccgaggc cactgtccca tcccctaccc    900
 agtcccccat acgcttccag cctgccccgg ccaaaacatc caccccactg gcccctctcc    960
 ctgtccaaag ccaaagtgac accaaggaca gactgggcag cccccttgct gtggatgagg   1020
 ccctcagacg gagcgacctg gtggaggagt tctggatgaa gagtgcggag atccgccgca   1080
 gcctcgggct cacacctgtg gaccgcagca aggggcccga gcccagcttc cccacgcctg   1140
 ccttcaggcc agtgtccctc aaatcctatt ccgttgaaaa gtccccccag gatgagggac   1200
 tccaccttct caagcctctg tccatcccca aaaggctggg cctgccaaag ccggaaggcg   1260
 agccgttgtc cctgccaacc ccccggtccc cgtccgacag agagctacgc agcgcccagg   1320
 aggagcgcag ggagctgtcc agcagctctg gcctgggcct gcacgggagc tcctccaaca   1380
 tgaagacact gggcagccag agcttcaaca cctcggactc cgccatgctc acgcccccct   1440
 ccagcccgcc cccaccgcca cccccgggcg aggagcccgc caccttgcgg aggaagctca   1500
 gggaggccga gcccaatgcc tcggtggtcc cgccgccctt gcccgccacc tggatgcggc   1560
 ccccccggga gcctgctcag ccccccagag aggaggtgcg gaagtcgttt gtggagagtg   1620
 tggaggagat tccctttgct gatgatgtgg aggacaccta tgacgacaag actgaggact   1680
 caagcctgca ggagaaattc ttcacgcccc cgtcctgctg gccgcgcccc gagaagcctc   1740
 gccacccgcc cctggccaag gagaacggga ggctgcctgc tctggagggg acgctgcagc   1800
 cacagaagag ggggctgccc ttggtgtccg cggaagccaa ggagttggcc gaggagcgca   1860
 tgcgagccag ggagaagtcc gtgaagagcc aggcgctgcg ggatgccatg gccaggcagc   1920
 tgagcaggat gcagcagatg gagctggcct caggcgcccc caggccccgc aaggcgtcct   1980
 cagcaccctc ccagggcaag gagcgccggc ctgactcccc cacacgcccc actctcaggg   2040
 gctccgagga gcccaccctg aagcatgaag ccaccagcga ggaggtcctc tccccgccgt   2100
 cggactcagg gggcccagat ggctctttca cttcatccga gggctccagt gggaagagca   2160
 agaagaggtc gtcactcttc tccccccgca gaaacaagaa ggagaagaag tccaaaggcg   2220
 agggccggcc cccggagaag cccagctcca acctcctgga agaagccgtc gccaaaccca   2280
 agtccctgtg gaagtccgtc ttctccgggt acaagaagga caagaagaag aaggccgacg   2340
 acaagttcct gccccagcac ccccttcagc ggggccacgg tggactctgg aaagcacagg   2400
 gtgcttcccg tccgtaaggg cagagctgca gctccggcgc cagctgagct tctccgagga   2460
 ctcagacctc tccagcgacg atgtccttga gaagtcctca cagaagtccc ggcgagagcc   2520
 aagaacctac acggaggagg aactgaatgc caagctgacc cggcgtgtgc aaaaggcagc   2580
 tcggagacag gccaagcagg aggagcttaa gcggctgcat cgagcccaga tcatccagcg   2640
 gcagctgcag caggtggagg agaggcagcg gcggctggag gaaaggggcg tggctgtgga   2700
 gaaggcgctc cggggcgaag caggcatggg caagaaggac gaccccaagc tgatgcagga   2760
 gtggttcaag ctagtgcagg agaagaacgc catggtgcgc tacgagtcgg agctgatgat   2820
 ctttgcccgg gagctggagc tggaagaccg gcagagtcga ctgcagcagg agctccggga   2880
 acgcatggca gtggaagatc accttaagac tgaggaggag ctgtcagaag agaagcagat   2940
 tctcaatgag atgctggagg tggtggagca gagagactca ctggtggcgc tgctggagga   3000
 gcagcggctc cgggagagag aggaggacaa ggacctggag gctgccatgc tgtccaaggg   3060
 cttcagcctt aactggtcct gagctcccac ccaacgctcc attttctgtt ggcatctgcc   3120
 tggccaggca gtggcatcca aaccacccgg agccgcgatc tgaggaggcc tggcacctcc   3180
 ttggagttta cgctcagatg cccgtgtgct gcttggaaag tggtcgagtc ccgcgtgcag   3240
 tggggagccc caggtgacag tggttatctg agacggctcc acctcctggg aggaggccca   3300
 cctggacctc ccactcagag gaggagcacg gcgtgtatgg catgacgcag gggaccaccc   3360
 cgcgcgctcc ctgaggatgt gctggctgtg cccctttttt ccactggcac atttggtaag   3420
 agagggaagc tgctccccgt cagaaccaca gtgcgccgtg cgaggggcac tgtcttcttc   3480
 atgctccctg gagcaccacc aaagaaacgt aaacaatacc ccacgaaagc agggtcaggg   3540
 gtcagggtgc gatcgagacc catgatgggg gcgtccagtc atgcccaccc cagcatcaca   3600
 ggagacatgg aggtgcgggc aggctcctga attattatgc aaattaggag gacgcaggag   3660
 gggtctgccc tccagccgaa caccacacac tggaccctaa gtggccaaat gcctgggccg   3720
 cttgctggct gtggcctgag gcttgtgggt tgctgcattt tgcttgtagt tcacaaccat   3780
 tttgacactg gaaaatgctg actttggggg acaggatgag gccctacatt ctaagccccc   3840
 agttggcaga caggcattgt ccctgttcca catttatgtc gggacaggag atgacctttt   3900
 cctccgtgtt tttcctgtgt ttgcacgttg aaatgaagct gacaacctgg caagacgctc   3960
 agccgcttca aacccttttt gtcaattaac ttatttttta atacttgaaa agaagtaact   4020
 tcgtttgtgt atctttacta gaggaactga tcacctgcgc ccgggtgcgg gagccacagc   4080
 ggcatctggt gcgtcctacg cgacctggtc cggggctgcc cgtcgctcct cacgtgcatc   4140
 tatttattag cctttctctt cgtatcactg gcctggctgg catcagggag ctgcccagaa   4200
 cccctgtgtg ggtcctcctc acagctttct gtcccctcct ccacccggtg cctgcctcac   4260
 cctggcgcta gaccaatctg gaccactcat gtgatgaggg tgcatttccg ttctgttttg   4320
 gggccaggcc aacagcagag ctgccactct caccctccca gtgagaattc cggctctgca   4380
 gaactcgccc ttggtctcag tttgggggcc agggcatcac cttcctccgc acatatgtta   4440
 aagaaggttt caggatgggc cctcatccac acaggccaag agggtgcaag gtgggaacct   4500
 ggaatcatgt gggctggtga gaattccctc ctcccagcct aagattcacc cagacggaaa   4560
 cgcgagtgct gcagtggatg ctgggatgca ggctggtgcc tctcaagcag atcagggact   4620
 cccgcccttc ctttcgaagg ggacgggcac ctgccttgcg ccggatcttc atggggacat   4680
 aaaggggcga gccccggaat cactagctcc tatagccaaa ctgttccttt ctcacggttc   4740
 cgcaccagcc tggctgtgta cagctcatca agccactgag ctaatcgggg tggggtgctt   4800
 gtccatcaaa gcagtcagca catagcccag cgaggagcca tccgggacca gacccgcctg   4860
 ccagggggcg cttccagccg cctggccgcc tccgtggggc tgggggccag ctggggagca   4920
 gaggcttggg cccttccaag gcgttcccgc agttggagca ggctgagtgg ctgtgctgac   4980
 cttgggcttt ccatgggaac cacactgtgc ttcaacttga acattcatcc cagctgcaaa   5040
 ggagcaaaga acctgtgtca tccttgtctg tccagaagct gccatctctc tcccatgcac   5100
 atccgggaga taacgccgct agtggccgcc acagcgctga ttctccacct gttctcacgt   5160
 gaggcaaagg tctccttttc ttttctcttt acttaaaaaa ggggagagga gggtttctag   5220
 attccatctt caaaccccag tctgtcccat aaaattggac gtgggaaaag accttcactg   5280
 cctgcgtggc cttttcccag acctttcctc gaatgccaca aaaccggtcc agccccggca   5340
 gagcggcctt tcgggccctt gtagctcctg ctggccccac aacagggaaa cagtttgcaa   5400
 agtggcttgg aaggagtgtg gcctagggat cttgctgtaa gtggccagac gtagcaggag   5460
 aagcccagtg tcaactttct ggtcctgggt cagccttaac actgtgggca tcctccacat   5520
 gcacacacgg cagcctgcag tcctggaagg tgggacccga gccttttgca gagaggcgcc   5580
 gcagagccgc aggcctgcgc cccagccttc tgctcccgga cttgtgagga cacccagttc   5640
 tagtagagca ctttttttaa agcttcccat tttgtaacca ctaagtttgc ggttaactgg   5700
 agtacctctg gtgacttcct gcgtcaagcg ttctcaagct gtgagaatgt gcgcagctcc   5760
 aggccaggtt ttctctcgga aagttaaagt ccttcccctt gaaaggcagg gaagccagga   5820
 tggatacaca tatatccaca cgcataaaaa cccccaggtg cgggagcagc cccagactca   5880
 aggactgaac taaactggag gtctgaatac ccgtggaggt cccacatgcc agccttcccc   5940
 tggagggcaa ggccggaggc cgctcccgcc cctgggcttg aggatgcctg acaccccgtg   6000
 ggcttcccag gcctgcccag atgatgcctt caggcctctg tccctggcgg ccatcctcag   6060
 gccgattttg accagcaatg atagactctt cttaaccctt tcaaaataaa tttttcagtg   6120
 ggacagagag gggaagttaa aaaacatttt tttaaaaggt ggtaacatct gacccacaaa   6180
 gggaatgggt ctgttttatg caaaataaaa gtttttcaaa tnnnnnnnnn nnnnnnnnnn   6240
 ggggcggccg ataaaaagga accctcaagg ggcccaggtt tacgcgggca tgcaagggaa   6300
 cacccctttc cctaaagggg ggggaaaaaa aacctccccg ggaattttgg g            6351



      <210> 424
      <211> 601
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(601)
      <223> n = a,t,c or g


      <400> 424
 gcggccctac tactactaaa ttcgcggccg cgtcgacata aggagtcctg cttatcacgt     60
 gtgaatgttc tctctgggca gcgttgtgat ctttgccacc ttcgtgactt ttatgcaatg    120
 catcatgcta tttcataccc ntaatgaggg agtttccggg ggattcaacc aggaaatgca    180
 tggatctcaa agggaaacaa acaccccaat aaactcggag tggcagactg acaacttgtg    240
 agaccttcaa cttgttacga aaacagaaat tttcatgttg gcacccttgt ttctacaccc    300
 tgtgggttat gaccaaagac aactggccaa agaatcttcc aagaaggaag gcttgcaatg    360
 tatatcgtgg ttggagaaga aaggacccca aaaaaagacc tgtcctgtcc agtgaatggg    420
 gtaatctaat tgtgcttcct agtagggcac ggggcctccc agggccaggg cttcattcct    480
 ccccttggcc cctaatagtt caatgatttg tgtagccatg ccctatgcag taagaaagat    540
 tttttgagca caccagagga aaagtaaaaa ggttggcccc tagggggtcg cttttcgcgc    600
 g                                                                    601



      <210> 425
      <211> 872
      <212> DNA
      <213> Homo sapiens


      <400> 425
 agcagggcag cgagcgagat gcagcaccga ggcttcctcc tcctcaccct cctcgcccct     60
 gctggcgctc actcgccgcg gtcgccaaaa agaaagataa ggtgaagaag ggcggccccg    120
 gggagcgagt gccgctgaag tgggcctggg ggccctgcac ccccagctag caaggatttg    180
 ccgcgtggtt ttccgcaagg gccacctgcg gggcccaaga ccaagggcat ccgggtgcag    240
 ggtgccctgc aacttggaag aaggagtttt ggagccggac tgcaaagtcc aagttttgag    300
 aactgggggt gcgtgtgatg tgggcacagg ccaaccaaaa ggtccgccaa ggcacccttg    360
 aagaaggcgc gcttacaatg ttcaagtgcc aggagaccca tccggggtca accaaagccc    420
 ttgcaacccc ccaaggacca aaaggcaaag gccaaaagcc aagaaaggga agggaaagga    480
 cttagagcgc caagcctcgg atgcccaagg agcccctggt gtcacatggg ggcctggccc    540
 aacggcccct ccctctcccg gggcccgaag atgtgaccca accagtgcct ttctgtctgc    600
 tcgttagttt ttaatcaatc atgccctgcc cttgtccctc tcactcccca agccccaccc    660
 ctaaagtgcc caaagttggg gaagggacaa gggggatttc tggggaagct ttgagccccc    720
 tcccccaaaa agcaatgttg agtcccagaa gcccgctttt gttcttcccc tacaattcca    780
 attacccaag aaacacatca aataaactga ctttttcccc ccaataaaag ctcttctttt    840
 ttaatatata aaagcccctt aaaaaaaaaa aa                                  872



      <210> 426
      <211> 2167
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2167)
      <223> n = a,t,c or g


      <400> 426
 cccacgcgtc cgggcggcgc acaagtcagg tccggcacat gtttccgcgg agcggaccca     60
 gcaatgacgg atgatatcac ctcttcttct ctggtgagag tctgaggata gagacttttt    120
 tctcaccatg aatgtcaccc cagaggtcaa gagtcgtggg atgaagtttg ctgaggagca    180
 gctgctaaag catggatgga ctcaaggcaa aggcctcggc cggaaggaga atggtatcac    240
 tcaggctctc agggtgacac tgaagcaaga cactcatggg gtaggacatg accctgccaa    300
 ggagttcaca aaccactggt ggaatgagct cttcaacaag actgcggcca acttggtagt    360
 ggaaactggg caggatggag tacagataag gagcctttct aaggagacca cccgttataa    420
 tcatcccaag cccaacttgc tgtatcagaa gtttgtgaag atggctacat tgacttcagg    480
 tggagagaag ccaaacaaag acttggagag ctgcagtgat gacgacaacc aggggtccaa    540
 gtccccaaag attctgactg atgagatgct gctccaagcc tgtgaggggc gaacagcaca    600
 caaggctgcc cgtcttggga tcacaatgaa ggccaagctt gctcgcctag aggcccagga    660
 gcaggccttc ctggctcgtc tcaaaggcca ggaccctggg gcccctcaac tgcagtcaga    720
 gagcaagccc cccaaaaaaa agaaaaagaa aaggaggcag aaagaggagg aagaagctac    780
 agcatctgaa aggaatgatg cagatgagaa gcacccagaa catgctgagc agaacatcag    840
 aaaaagcaag aagaagaaaa ggcgacatca agaaggaaag gtctcagatg aaagagaggg    900
 tacaactaaa gggaatgaga aggaggacgc tgcaggaaca agtgggcttg gggaattgaa    960
 tagcagagag caaaccaatc agtccctcag gaaagggaag aaaaagaaga ggtggcacca   1020
 tgaagaggag aagatggggg tcttggagga aggaggaaaa ggcaaggagg ctgcaggcag   1080
 tgtcaggaca gaggaggtag agagcagggc atatgctgac ccatgcagcc gaagaaagaa   1140
 gaggcagcaa caggaggagg aggacttgaa cctagaagat agaggtgagg aaactgtttt   1200
 aggtggtgga accagggaag cagagagcag agcatgcagt gatggaagaa gcaggaaaag   1260
 caagaagaaa agacagcagc atcaagagga ggaggacatc ttggatgtaa gggatgagaa   1320
 ggatagcggg gctagggaag cagagagcag agcacacact ggctcaagca gcagaggtaa   1380
 gaggaagagg cagcagcatc ccaagaagga aagagctgga gtcagcactg tccagaaagc   1440
 caaaaagaaa cagaagaaga gagactaaag gtctggtaaa ggtagggctc aattgattga   1500
 ttttcaggag ttgaagcctc aaagaccagg gttgatgcag gtctgcaggt cttctgcacc   1560
 cccctcaatg aggagtccct cccagaaagg aaactgatct ctgggatgtc agctgctgag   1620
 aggagcaagc ggtagtacca ccccttagtt gagggagtca gcacagtcct ttctgcagct   1680
 tctaacccag gaccatgaac tcaggtgcct agagaagcca ggcagctaaa ggacaaggaa   1740
 tgctgggggc tgtgggaaca ggaatgcaga taccctttga aggagcattc ctgctaaaag   1800
 aagctgaaaa tgtagaccta tgtgaagtgc tctgatttct aaatattgtg aaggttaaga   1860
 aaaacataaa tttaggtcta tgggctagat ttagcccaca gttgccagtt tctagcgcta   1920
 ccaaatgaat gaataaacat gagcttgcgc tcctagccta gagataaatc ctgactggca   1980
 tctctgttcc cagcctggga aggtcctgaa tacaaattag aagatattcc ttggaggcct   2040
 ttgaagaaat tccttcggtt aacctctttg taggcttgct acactgataa gtagaagtag   2100
 ctccctgtct gtgtcccana tgaataagaa ttgtgtaaag gacagcacaa ctcacttggc   2160
 atctaac                                                             2167



      <210> 427
      <211> 364
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(364)
      <223> n = a,t,c or g


      <400> 427
 ggaggtggac gcaaagcagc tgatccagga agcctgtcgg agctgcctgg agcaggctaa     60
 actgctcttt tcagatggag aaaaagtaat acccagagtg acccatgagc ttccaggaat    120
 aaagcgtggc cgtcaggcag aagaagaatg tgcccatcga ggaagccccc ttcctaaaaa    180
 gaggaaaggc tggcctcctg gacacatcct gtcaagcgac cgggcagccg ccggcatggt    240
 atggaaacca aaatcccgta cccagttcgc cgggaaggcc ccaagtgaga cacagctcgc    300
 ctgaatgaat ctacccccta tgtgttgggc gctctgttcn cntaacccaa nccggtcgtt    360
 caca                                                                 364



      <210> 428
      <211> 316
      <212> DNA
      <213> Homo sapiens


      <400> 428
 ttcgttaata aagttttatt gagtgattat tacatgcaaa gcacaagtct gcaaaacagt     60
 tcctttgaat gcttttcccc tagggtggta aattaataaa cattaagtac ttattttata    120
 ccagttattg attcctgtcc ttcccttggc attttctctt ggcagcctcc cgagcacaac    180
 aaggagaggt gatgaggttg gcatgtcgtt tggatcccaa aactagcttc cagatggctg    240
 gggagtggct aaagtatcaa ctatcaactt ttcttgatgg ctggttctgt gaattggaag    300
 tttttttcat tactga                                                    316



      <210> 429
      <211> 584
      <212> DNA
      <213> Homo sapiens


      <400> 429
 caataagggc ctgccagaag tacatcagtc caaagctaag caccacagct tgccacggac     60
 gtctcacggg ccccaagtgg cagttcctgt gcctggcccc caggtcaaag tctttcatgc    120
 cggcactcag cagcagaaaa acttcacgcc cccatctcca tttgccaata agctccaagg    180
 cccaaaggct tctcccacac agtgtcatcg ttccctcctg cagttagtga agacagcggc    240
 caaaggccag ggcttccatc cctctgcacc agccacctca ggaggcctgt cagcctccag    300
 cagcagctct cacaagaccc cagcctcgtc ctcttctgcc ctgagccatc cagcaaagcc    360
 acattcagtc agctctgcag gctcatctta caagaataat ccctttgcca gctcaatctc    420
 caaacatggg gtttcttctg gcagctcttc ctcgggagga acaccagtcc agagttctgt    480
 ttctgggagc ctggtccctg gcatacagcc tccctccgtg ggacaggcca ccagccgacc    540
 cgtcccaagt tcagcaggga aaaaaatgcc tggtttcccg aaag                     584



      <210> 430
      <211> 426
      <212> DNA
      <213> Homo sapiens


      <400> 430
 cttctaaact gatcaatatg ggagtagcat tcaatcaccc acaggttaac tcactctaga     60
 gagaaatctt gtgagtgtaa tctgtatggt aaaactttga gctcaaactt tccccctacc    120
 aaaaaaaaag tatctactgg ggagctgccc aggtaatgca gtagctgtag gaaagccttc    180
 agtgatggct tcagggagtc acatgacaac tcacaataag gggaaaccct gtgtgtggca    240
 tcaaaaatgg aaaaccaggg gacactcatt ccttaagtca catttcggag atcatacaac    300
 agaggaatat gttgagtata cacagtgttg aaaagcctgt gacacaaaca gtcatattac    360
 caagcacaag acagtatagt ttggtatgct ataaaagcct tgaatattct ctccatttct    420
 cgtgcc                                                               426



      <210> 431
      <211> 399
      <212> DNA
      <213> Homo sapiens


      <400> 431
 ccccctccag aactgcaaag ctcccaaagg cggggataag aggagctaga gcttgcctca     60
 cccgctgtag ccgccgagag cccagaatgt actggcggat ggggcctgcc tgcaccccgg    120
 ggaggcgccc accccggacc cccacccctc cgcactgtga aagactaact cctgcaactg    180
 gaaagcgggg gcgcccgccg acgaggaggc caccgtgcca agccggcaga ggtcatgcca    240
 ggcgccaagg gccatgtgcc cagctgctgc tggctgggtg ggccagggag cccgccagca    300
 gaccccacac agcatgtccg ccccagggca aagcctccca ctttcgctct gcgcccgtcc    360
 cagctcgcct cagccctgtt atctcagaac caatgtatt                           399



      <210> 432
      <211> 412
      <212> DNA
      <213> Homo sapiens


      <400> 432
 aacacagcac cagtaacctg tgccaggggc tgtggacggg ggcaacacag gagcaggtca     60
 cggggaaggg ggatgtaagc tttctgagca aactcccaga gcacccaggg cagaaacagg    120
 cggctagaag ccgggcaacg cgggtgcaga gcacagaccc acgtccatgg ttttcctacc    180
 agacgggcct ggcagcggac gcactggcct cccccgggcg gcgctggctc agccaccgcg    240
 gcacccttca tgaggccggt attccgctct tgcacctccc ccaaagccca gagaagacga    300
 gacagacact cacgcaggct aggtgtcggg accggagtgg ccgagtagac ggcagtggag    360
 aatgcacgca gagtccttgc cctcgactgc agagacagcc atgctgggag cg            412



      <210> 433
      <211> 989
      <212> DNA
      <213> Homo sapiens


      <400> 433
 ggaattcccg ggtcgacgat ttcgtcggga agatggcggc ctccaggaat gggtttgaag     60
 ccgtggaggc agagggcagc gcagggtgcc ggggaagctc gggaatggag gtggtgcttc    120
 ctttggatcc tgccgtcccc gccccgctgt gccctcacgg acccactctt ctgtttgtaa    180
 aggtgaccca agggaaagaa gaaactcgga ggttttatgc ctgttcagcc tgtagagata    240
 gaaaagactg taattttttt cagtgggaag aatgaaaagt tgtcaggagc tagacttgct    300
 gcccgagaag ctcataaccg aaagatgtca gcctcccctg tcccgaacgc agtgtgtgga    360
 aaggtacttg aagtttattg agttgccctt gtcatcagag aaagttttgt caaacatgtc    420
 agcagttgtt gttaccagat gactgggggc aacatagtga gcatcaggtt ctgggtaatg    480
 tgtccattac ccagttaaga aggcccagtc aactccttta tccactggaa aacaagaaga    540
 caaatgccca gtatctgttt gctgatcgga gctgtcagtt cttggtagac ttactttctg    600
 ccctcggatt cagaagagta ctgtgtgttg gaacaccaag gttgcatgag ctgatcaagt    660
 tgacagcatc aggtgacaag aagtctaaca ttaaaagcct tttattggat attgattttc    720
 ggtattcaca gtttttatat ggaagatagc ttttgccatt ataatatgtt taaccatcat    780
 ttctttgatg gaaagactgc ccttgaagta tgcagagcat ttttacagga agataaaggc    840
 gaaggaatca ttatggtgac ggatcctccg tttggtggct tggttgaacc tctggctatt    900
 acattcaaga agttaattgc tatgtggaaa gaaggtcaaa gccaaggtgt ataatttatt    960
 actgcaaaat aaatacatat ctatatatc                                      989



      <210> 434
      <211> 445
      <212> DNA
      <213> Homo sapiens


      <400> 434
 agtcagtgcg gtggaattcc ccaggtcgga gagatcttct cggcggccgg cgccgccttc     60
 acgaagctcg gggagctgac gatgcagctg catcccgtgg ccgactcttc tcctgcgggc    120
 gcgaagtgga cggagacgga aatagagatg ctgagggctg ctgtgaagcg atttggggac    180
 gatcttaatc acatcagctg tgtcatcaag gaacggacag tggcccagat aaaggccact    240
 gtgaaacgca aggtatatga agattctggc atcccccttc cagctgagtc acccaagaaa    300
 gggcccaaga aggtggcatc tggtgtcttg tcacctcctc cagctgcccc tcctcccagc    360
 agctccagtg tccctgaggc cgggggtccc cccataaaga aacagaaggc tgatgtgaca    420
 ctcagtgctc tgaacgactc cgatg                                          445



      <210> 435
      <211> 379
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(379)
      <223> n = a,t,c or g


      <400> 435
 cattctccat tctcggttaa ccaggggcac agtgcnnnnn nnnnnnnnnn nnnnnnnnnn     60
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    120
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    180
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    240
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn gccgaccatt cattctattc    300
 tgaaatagga gaaaaccgcc ctgtgggagg caagatatgc tggcagcaat actgctctgt    360
 tactctttgc tacactgag                                                 379



      <210> 436
      <211> 370
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(370)
      <223> n = a,t,c or g


      <400> 436
 gcggttgact gtagagccgc tctctctcac tggcacagcg aggttttgct cagcccttgt     60
 ctcgggaccg caggtacgtg cctggcgact tcttcgggtg gtccccgtcc gccctcctcg    120
 tccctaccca gtttcttgct tccctgcccc atctccgccg ctccccgcag cctccgccga    180
 gcgccatggc tcctaggaag ggcagtagtc gggtggccaa gaccaactcc ttacggaggc    240
 ggaagctcgc ctcctttctg aaagacttcg accgtgaagt ggaaatacga atcaagcaaa    300
 ttgagtcaga caggcagaac ctcctcaagg aggtggataa cctctacaac atcgagatcc    360
 tgcggctccn                                                           370



      <210> 437
      <211> 457
      <212> DNA
      <213> Homo sapiens


      <400> 437
 aagatgaaag cgccggaatt tgtggaaaca agatggagga ttcggcctcg gcctcgctgt     60
 cttctgcagc cgctactggt acctccacct cgactccagc ggccccgaca gcacggaagc    120
 agctggataa agaacaggat agaaaggcag tggacgctct cttgacgcat tgcaagtcca    180
 ggaaaaacaa ttatgggttg cttttgaatg agaatgaaag tttattttta atggggagat    240
 tatggaaaat tccaagtaaa gaactgaggg tcagattgac cttgcctcat agtattcgat    300
 cagattcaga agatatcttg ttatttacga aggatgaacc caattcaact cctggaaaga    360
 cagaacaagt ttatagaaag gttttaaaca agcatgggat taaaacccgt tctcagatta    420
 tctccccttc aaactctaaa gaaaggatat ttatcct                             457



      <210> 438
      <211> 492
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(492)
      <223> n = a,t,c or g


      <400> 438
 ntgaccaccc tttacaccat cttggcacga tgggggcaag ccctcggaga gggccagggg     60
 tcctaggtat tcagcgccca ggcctgtttt tcctaccaga cctgccttca gccccctttg    120
 tgccgcgtga cgcccagcgg cacgacgtgg agctcctgga gagcagcttc cctgccattt    180
 tgcgggactt cggggctggg agctgggact tctcagggac tacccctccg cctcggggct    240
 gggccccacc tctggccccc gggtgctacc agctcctgct gtaccaagca ggccggtgcc    300
 aacccagcaa ctgccgccgg tgcccggggg cctatcgagc actgaggggg cttcgaaact    360
 ttatgagcgc caacaccttc ggcaatgccg gcttttccgt tctcctgcct ggcgccccgc    420
 tcgagggccg ctgtgggccc accaatgccc gggtcagaag ccatgtgggc ctaaagaacc    480
 gtccgggctg gc                                                        492



      <210> 439
      <211> 406
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(406)
      <223> n = a,t,c or g


      <400> 439
 cgtgtacaaa cttgtgacct cagtgtttat actgagacat gtcagattag ctcatattta     60
 ttttaattat aatggtcata ttgtattcca gataaaatga aagatgccat catagctaaa    120
 ttggctaatc aggctgcaga ttattttggt gatgctttca aacagtgtca atacaaagat    180
 actctcccca aggtcagtta ttgtttttat aaacacttgc ttactttgca tgtgaaatat    240
 ttagactttt ttgtgtataa gaagcaagtt gaaacttata aagaaatttg aagttttaat    300
 agagttatct gaagtatata gtagaaatag cnnnnnnnnn nnnnnaatta aaaaggccgg    360
 accatttttt ttatgttaag gggaggcctt tgcctttacc tttaag                   406



      <210> 440
      <211> 406
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(406)
      <223> n = a,t,c or g


      <400> 440
 tctaacttta ttatgtattt gacagacaaa gccacagacc caagcatgtc ggaacaggat     60
 tggtcagcta tccagaattt ctgtgagcag gtgaacactg accccaatgg gtaaggtaac    120
 ttctcacaca catagttgac tctgggggca ccccacactg agtgtaggcc tttgtctctc    180
 aagattgttt tagggttaag ctctctaggc annnnnnnnn nnnnnnnnnn nnnnnnnnnn    240
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    300
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnng cagtcaggct ggcattcatt    360
 ctctcattat cccctataat cctgccttgg tctccggacg cgtggg                   406



      <210> 441
      <211> 409
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(409)
      <223> n = a,t,c or g


      <400> 441
 gggaagtctt catgcatcag gtctccctta ataggcacat gagatctcac actgaacaga     60
 aaccaaatga gtgtcacgaa tatggagaga agccacataa atgcaaagaa tgtgggaaaa    120
 ccttcactcg cagctccagt attcgaaccc atgaaagaat atatactgga gagaaactat    180
 aaagaaaatt ctatatccat cccatctttt gtggggtttg ttttttgnnn nnnnnnnnng    240
 gaaaggaaat ttggctnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnncc ggggttcccc    300
 gaaccctcca aaatggggaa aaataatttg gttttttata aggaaaaaaa aacccccccn    360
 ccnnnnnnnn nnnnnnnnnn ngaagaaaag agaagagaca aaggggttt                409



      <210> 442
      <211> 364
      <212> DNA
      <213> Homo sapiens


      <400> 442
 gctgaaggag gctcggggca agatcgacat gctgcaggca gaggagacag ccttgaagac     60
 gctggacatc acgtccacac cagcctctcc caaccgcgag cttcaccccc agctgctgag    120
 ccccaccaag gccgggcccc gaaagggcca ctctcgccac aagagcacca gcagcaccct    180
 ctgccacgcc gtgtgtcccg ctgcgggaca caccctcacc ccaaacagag agggcaagga    240
 ggtggacaca atcctgtttg cagagttcca ggcctggagg gaatccccca ccctggacaa    300
 gacctgcccc ttcctggaaa gggtgtaccg ggaggacgtg ggcccctgcc tggacttcac    360
 gatg                                                                 364



      <210> 443
      <211> 1278
      <212> DNA
      <213> Homo sapiens


      <400> 443
 cagatgacta atgcatctaa ttcacaacag tctatttcaa tgcagcaatt ttctcaaacg     60
 tcaaatcctt cagcacactt ccacaagtgt agcagtcatc aagaaggaaa ttttaatgga    120
 ccttccccaa atatgacttc ttgttctgtc agtaattcac agcaattttc ttcacattat    180
 tccttttcca gtaatcatat atcaccaaac agtctacttc agtcctctgc agttcttgca    240
 tctaatcata caaatcagac tttatctgat tttactggaa gtaattcctt ttcacctcat    300
 agaggaatca agcaagaatc tactcagcat atcctaaacc ccaatacatc attgaattca    360
 aataatttcc aaatattggc attcatcaca tcctcagggt aattatagca attcaaaatt    420
 atctcctggt gcacatgaac ttcccagatc ctggttgact caggaactca aatgggccat    480
 ttcaatgatc atgtagaaac taatggcttt tcatctttag aagagaattt acttcatcaa    540
 gtggaatctc aaactgagcc attcacagga cttgaccccg aggacctcct tcaggagggt    600
 cttcttcctc actttgatga gtcaacattc ggacaagata attcaagtca cattttagat    660
 catgaccttg atcggcagtt tacttcgcat ctggtaacac ggccttctga tatggctcag    720
 actcagttgc aaagtcaggc tcggagttgg cattcatcat tttctaatca tcagcattta    780
 catgacagaa atcacctatg tttacagcga cagcctccat cttccaagaa gagcgatggt    840
 tctgggacat atactaagtt gcagaatacc caggtgaggc tcatgtctga aaagaacgca    900
 gagaaaaaag gtggaatcag aaagcaagca agaaaaggct aatcgtataa tatcagaggc    960
 catagcaaaa gcaaaggagc gtggggaacg caatattcca cgagtaatga gccctgaaaa   1020
 ctttcctact gcttcagttg aaggaaaaga ggaaaagaaa gggtaaaggg atgaaatcca   1080
 agccaaagga caaagacagc aaaaaaacaa aaacatgttc taagttaaaa gagaagacaa   1140
 aaattggcaa actcattatt acattgggta agaaacaaaa aagaaagaat gagtcttcag   1200
 atgaaatatc tgatgcagaa cagatgccac agcatacatt aaaagatcaa gactctcaaa   1260
 aaagaagatc aaatcgac                                                 1278



      <210> 444
      <211> 359
      <212> DNA
      <213> Homo sapiens


      <400> 444
 tattcactga cacccccaaa gcctaccata acgtcggtgc ccagagaaga tgctcagtaa     60
 atagttttgg aataaacaga tgctgtagtg gggagaaggg tttggattct ggatgatggg    120
 agaggcttgg ctgcaaaact ctcttgtccc aggaaactag ccagaactgc aagttaattt    180
 ccagttgaca gccagttgct ggtggagctc tggaggatgt gggggtgagg tgagagcacc    240
 catggggagg gctacttcta accagaacct tttttctgca cttcctgcag cttgagatta    300
 aaaaccatgt attcttcagc cccataaact gggatgacct gtaccacaag aggcttact     359



      <210> 445
      <211> 355
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(355)
      <223> n = a,t,c or g


      <400> 445
 acagcagtgg ctgctagcta acttcctcta ggccagaggg ggtcacatgc tggtgtttgg     60
 agactcttga gggcagcagg tggccaaagc agcgctgtgg atgggacctg gaggggatgt    120
 tgtgctcact ctccacttgt ttcccaggca gcagcagcag tgccctgggc ctgcagagcc    180
 tgggactgtc cggccaggca cccagctctt cctctctgga cgcaggaacc ctctctgaca    240
 ccacagcatc agctccagcc tcagacgacg agggcagtac agcagcgaca gatggttcta    300
 cccttcggac ctctcctgct gaccacggtg gtagtgtggg ctcggagagc ggngg         355



      <210> 446
      <211> 359
      <212> DNA
      <213> Homo sapiens


      <400> 446
 ctctctctcc gaagacatct ccttgaccca gtctatttat gacaagaagc ttgtgttaat     60
 gcagaaaaat ctccagggcc tggatccgaa agccctgaac aactgctctt tctgccatga    120
 agctgggcag ctggggccag agatccgaaa actgcaggag gagctggagg gaattcagaa    180
 gctgcttctg gcccaggagg tgcagctgga ccagacctta caggcccagg aggtgctctc    240
 caccaccagc agacaaatct cccaggagat gggcagttgc tccttctcca tccaccaggt    300
 taaccagtct ctggggctct tcctggccca ggtgagaggc tggcaggcca ccacagctg     359



      <210> 447
      <211> 377
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(377)
      <223> n = a,t,c or g


      <400> 447
 ngcactgaag gtgcagttta agagagaata tggttttatt tctcagaccc tgcaagagga     60
 aagatacagg tatgagcgac tggaggacca gctgcatgac ctgacggacc tgcatcagca    120
 tgagacagcc aacctgaagc aggagctggc cagcattgag gagaaggtgg cctaccaggc    180
 ctacgagcgc tcgcgggaca tccaggaagc cttggaatcc tgccagactc gcatttctaa    240
 gctggagctc caccagcaag agcagcaagc tctgcagaca gacaccgtga atgctaaagt    300
 tctcctgggg aggtgcatca acgtgatcct ggccttcatg actgtcatct tagtgtgtgt    360
 gtccaccacg atgtatt                                                   377



      <210> 448
      <211> 395
      <212> DNA
      <213> Homo sapiens


      <400> 448
 cgcaccctga acaagtgcca ggcctccaca cgtgcccgca ccctcacctc cgactggcgc     60
 accgtgggct cccagcatgg tgtcacggtc actgagagtg acagctatag tgccagcctg    120
 tcgcaggaca cagacaaagg aaggaacagc atggtgtcca ctgagagtgc ctcttccacc    180
 tacgaggagc tggcccgggc ctatgagcat gccaagctgg aggagcagct gcagcacgcc    240
 aagtttgaga tcaccgagtg cttcatctct gacagttcct ctgaccagat gaccacaggc    300
 accaacgaga acgccgacag catgacatcc atgagcacac cctcagagcc tggcatctgc    360
 cgctataccg cctcaccacc caagccccat gtatt                               395



      <210> 449
      <211> 441
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(441)
      <223> n = a,t,c or g


      <400> 449
 ccatggtgga ggtctccatc gtccagctgc cacccttcag catcagcacc agccgcgctg     60
 caccccccaa gtcccgcctc tcagacatca ctggctccag caagaccagc cggggaggtg    120
 gaggcagtgg gggcggagag cctcccaaaa gccccccgga acgggctgtg cttgtgtctg    180
 aagtgaccac cacctcggcc ctggtcaagt ggtctgtcag caagtcagca ccccgggtga    240
 agatgtacca gctgcagtac aactgctctg acgatgaggt actgatttac aggatgatcc    300
 cagcctccaa caaggccttc gtggtcaaca acctggtgtc agggactggc tacgacttgt    360
 gtgtgctggc catgtggaat gacacagcca cgacactcac ggcctgtgtt ngnccgctcg    420
 gaggctcacg cacggacgcg c                                              441



      <210> 450
      <211> 407
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(407)
      <223> n = a,t,c or g


      <400> 450
 cctgaagagg acattgagca aagagatcct cttccgagag ctggaggtgc gacaggttgc     60
 cctgagacat cttattcact tccttaagga aataggggat caaaagttgc ttttagacct    120
 cttcaggttc ctagatagaa cagaagagct tgcgctatct cattatcgag agcatttgaa    180
 cattcaggac cctgacaaac gaaaagaatt tcttaaaacc tgtgttggtt tgccattttc    240
 agcagaagat tccgcacaca tacaggacca ttacacgctc ctggaacgtc agatcattat    300
 tgaggcaaat gatcgccatc tagaatcagc aggacagact gagatcttcc gaaagcaccc    360
 ccgcaaagcc tccatcatca acataacacg agaacancac gtgtatt                  407



      <210> 451
      <211> 741
      <212> DNA
      <213> Homo sapiens


      <400> 451
 aggctgaggc aggagaatgg cgtgaaccca ggaggcggag ttgcagtgag ctgagatagc     60
 gcctctgcac tccagcctgg gtgacagagc aagactccgt ctcaaaaaaa aaaaagatac    120
 catgttggcc gggagcggtg gcacacgcct gtaatcccag cactctggga gcccaaggcg    180
 ggtggatcac ctgaggtcag gagtttgaga ccagcctggt caacatggtg aaaccccatc    240
 actactaaaa atacaaaaaa ttagctgggc gtggtggcgg gcacctgtag tcccggctac    300
 tcaggaggct gaggcaagag aatcagttga acctgggagg tggaggttgc agtgagctaa    360
 gatcgcgcca cttcactcca gcctgggtga cagagcgaga ctccatctcg aaaaaaataa    420
 aagaacttcc cgtgtccgtt tttgcttttt ggatgctggg agtgtcacaa ctcagctatc    480
 caatcaaggc agagctggcc tccaggatgc cagagccaga gctttgtggt tcatctctag    540
 aggttcaaca ggaccctgtg gatggcccaa gttcgtttct ctgcacttac ctcttcgggg    600
 ttgtcctcaa aacgttgccg tgtcagctct cacttttcac agcaactctg ggcctcctac    660
 cttgggactg cgccacttct gtctccttag ataacctcca ttccgcatag ctaaattgct    720
 gcaccctccg acactggcaa a                                              741



      <210> 452
      <211> 396
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(396)
      <223> n = a,t,c or g


      <400> 452
 caatttgttt atctgtgctg tgtagatgga gatgaattgt ttctaatttt tagctaatac     60
 agataaagat actatgaata ttcatgtata agtttttata tggacatatg cattcttttc    120
 ttttgagtga attcctggga atggaatggt aggtagattt tttttacttt ttgtttttta    180
 ttttattttt tgttttttat ttttttttaa gacagagtct cactctgttg tccaggctgg    240
 agtgcagtgg tgcaatcttg gctcactgca acctccacct cccaggttca agcaattctc    300
 ctgccacagc ctcataagta gctgggatta caggagtgtg ccaccaagcc caggtaattt    360
 tttaaatttn ttagtagcaa tgggggtttc accatg                              396



      <210> 453
      <211> 784
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(784)
      <223> n = a,t,c or g


      <400> 453
 agaaacagag tttcaccatg ttggccaggc tggagaattg ctgtaatagt tttccaactg     60
 gcccctgtcc ttcctctctc ttgctctcct cccatctcat ctgcacctag cagccagagt    120
 gatcctgata ctctcggcct ttacttccac ctccctcaga gcagcagcct gtcaaaacac    180
 cagattacaa caaatttagt ttaaaggtct caattagcgt tattggcaat tctagaatca    240
 ggcaacagac tcattgaatc aggaacagat tcactccata aaatacagag agtgctgcaa    300
 tgagctgggt agaagaggtt agttttatag acaggaaggg gctgtcaaag gcagaaagaa    360
 atgaagaaca aaaaaaaaga ttgatttttt ttttttttga gacaggatct cactctgtca    420
 tccaggctga agtccaatcc cacaatcatg gctcactgca gccaccacct cctgagctca    480
 agtgatcctc ccatctaagc ccccaagtag ctaggactac aggagcacac caccacacct    540
 gggctaattt ttgtattttt tgtgggagac agggttttca gtatgttacc cagggttggg    600
 actgggaaac ccttgggctt caaggcaatt ttggcctgcc ttcagccttc ccaaagtgtc    660
 tggggattac agggcgtgac aaccttggca caggggccag atttcatcat tttcaaagtt    720
 tacttttcta ttattgcggg gcccggaaca ggggtngggt ttgacattca gttttttttt    780
 tttt                                                                 784



      <210> 454
      <211> 910
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(910)
      <223> n = a,t,c or g


      <400> 454
 acggaaccgg ctcgcgagcg cagctatggc tgctttcgta ccctgtgcgt tagacaccag     60
 ctgctcctcc gtcttctcag gagaccagct ggtccaacat atccttggaa cagaagatct    120
 tattgtggaa gtgacttcca atgatgctga gagattttat ccctggacca ttgataataa    180
 atactattca gcagacatca atctatgtgt ggtgccaaac aaatttcttg ttactgcaga    240
 gattgcagaa tctgtccaag catttgtggg tttactttga cagcacacaa aaatcgggcc    300
 ttgatagtgt ctcctcatgg cttccactgg caaaagcatg gtttacctga ggtgatgatc    360
 tttggtctgc gattagagtg tcttgaagat ggtattaaac cggcaaaaag gtcaagaatg    420
 gtgcatcaaa catggctttg aattggtaga acttagtcca gaggagttgc ctgaggagga    480
 tgatgacttc ccagaatcta caggagtaaa gcgaattgtc caagccctga atgccaatgt    540
 gtggtccaat gtagtgatga agaatgatag gaaccaaggc tttagccttc tcaactcatt    600
 gactggaaca aaccatagca ttgggtcagc agatccctgt cacccagagc aaccccattt    660
 gccagcagca gatagtactg aatccctctc tgatcatcgg ggtggtgcat ctaacacaac    720
 agatgcccag gttgatagca ttgtgggatc ccatgttagg atctgggata tttcaaggaa    780
 ttaggccagt ctttaccatg ggagggaggg agatgtggga gatttttgaa agantttttt    840
 caaagtttaa agggaattga aaggacaagg gtttgcgacg ttttcctnct tgnaggccan    900
 ggganagttg                                                           910



      <210> 455
      <211> 454
      <212> DNA
      <213> Homo sapiens


      <400> 455
 gaaaaaccct actgcttacg ccaagcttgg cacgaggcgg gcggctccgg gagccaacat     60
 gcctcggtat gcgcttctgg tcttgggccc cgcgggcagc gggaagagca cctactgtgc    120
 caccatggtc caccactgtg aagccctcaa ccggtctgtc caagttgtaa acctggatcc    180
 agcagcagaa cacttcaact actccgtgat ggctgacatc cgggaactga tcgaggcgga    240
 tgatgtaatg gaggatgatt ctctgcgact cggccccaac ggaggattgg tattttgcat    300
 ggagtacttt gccaataatt ttgactggct ggagaactgt cttggccatg tacaggacga    360
 ctatatcctt tttgattgtc caggtcagat tgagttgcac actcacctgc ctgtgatgaa    420
 tcagctggac cagcagctct agcagcgaga gttt                                454



      <210> 456
      <211> 438
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(438)
      <223> n = a,t,c or g


      <400> 456
 aaaagcagat cccccnncta ntgngaggan nccnccacgc gtncgcacaa cctcactatg     60
 ncttnnnnaa actattgttc gggaaactcc aactcaggat ctctaggggc tcccgccata    120
 ttcctctcac ctacatcgac ctctgcccta ccagcgtgag ctgtggagat gtcctctact    180
 tacccactag ctctcaagac catacctggg tcacagacaa ctgccaagag acctgcggtg    240
 aaccaaccag ctgccagccg gtccactgtg agaccggcaa tcttgaaacc tcttgcggtt    300
 cttccactgc ttactacgtg cccaggcctt gccaaggaag cagttttctt cctgcttctt    360
 tcttctccag ttcctgcctt ccagtatcct gtagaccaca gaggtatgtg tccagcggct    420
 gtcgtccact gatgccgt                                                  438



      <210> 457
      <211> 419
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(419)
      <223> n = a,t,c or g


      <400> 457
 gcatttcggn ngatttgtcg accgacccgc gcggcgacac ggttgtttct tgaaatctgg     60
 cgttgggaat ggtcatgtgg aacaggccat gccagagggg ggctcaacaa cctgtggtag    120
 gtgagcccac tgcagagggg gagccacacc tgcccacggg ccgggagctg actgaggcca    180
 accgcttcgc ctatgctgcc ctctgtggca tctccctgtc ccagatattt cctgaacccg    240
 aacacagctc cttctgcaca gagttcatgg caggcctgga gaagtggctg gagttgtctg    300
 aaactgtctt gccaaccatg actgcttttg cgagcggcct gggaggtgaa ggaacagatg    360
 tgtctgttca aactttactg aaggacccca tcttgaagga tgacccgacg gggatcacc     419



      <210> 458
      <211> 595
      <212> DNA
      <213> Homo sapiens


      <400> 458
 ctgggaaggg agaatggcgg cgcccgggct gcggctggga gcgggaagac tctttgaaat     60
 gcctgcggtg ctagagcgac tgagccgcta taatagcacg tcccaagctt ttgctgaggt    120
 gctgcggctg ccgaagcagc agctgaggaa gctgctgtac ccgctgcagg aagtagagcg    180
 gttcctcgcc ccctacggga ggcaagacct tcacctgcgt atctttgacc caagcccgga    240
 ggacatagcc agggcggaca acatcttcac ggccactgaa cggaaccgca tcgactacgt    300
 cagctccgcc gtccgtatcg accacgcccc ggaccttccg cggccagagg tgtgttttat    360
 aggcagaagc aatgttggaa aatcatctct aatcaaggct ttattttcac tggcccctga    420
 ggttgaagtc agagtctcca aaaaaccagg acacacaaag aaaatgaatt ttttcaaagt    480
 tggaaaacat tttacagtgg tggacatgcc aggttatggc tttagagcac ctgaagattt    540
 tgttgacatg gtagagacct atctaaaaga acgaaggaac ttgaagagaa cattt         595



      <210> 459
      <211> 432
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(432)
      <223> n = a,t,c or g


      <400> 459
 caatggccgt cgccgcacaa cgacgaggct gggaagaccc tggtgttacc ccacttattt     60
 gtcttgttgc ccacgaatcg tccagtcaaa cgacctcact gaggcggcat atagtctctc    120
 ccgggatcaa aaacgtatgc tgtatctgtt cgttgaccat atcagaaaat ctgatggcgc    180
 cctacaggaa catgacggta tctgcgagat ccatgttgct aaatatgctg aaatattcgg    240
 attgacctct gcggaagcca gtaaggatat acgggatgca ttgaaaagtt tcgcggggaa    300
 ggaaggggtt ttttatcgcc ctgaagagga tgccggcgat gaaaaaagct atgaattttt    360
 tccttggttt atcaaacgag cgcacagtcc atccagaggg ctttacagag tacataatca    420
 ttcatatctc an                                                        432



      <210> 460
      <211> 102
      <212> DNA
      <213> Homo sapiens


      <400> 460
 tgtcatggcg gaaacagcgg ttatcaatca caagaaacgt aaaaatagcc cgcgaatcgt     60
 ccagtcaaac gacctcactg aggcggcata tagtctctcc cg                       102



      <210> 461
      <211> 406
      <212> DNA
      <213> Homo sapiens


      <400> 461
 tttcgtgctg ggtggtcggg cgcttggtcc ggtagttggt cggtggacca gcggcccgtc     60
 gctcgcttct ggtctctcat gtttgaaggt gggagggaca cggcagcggg ccgctcacct    120
 gagccgtccg gataggagcc ttggccccgt acccagtaag agtaggatga ggccatgcgg    180
 gcataaggag ttatggcttc tgatgctagt catgcgctgg aagctgccct ggagctgatg    240
 gacgggatca ttgcatgcac taaaacaggt gcagatctta gtgatggtac ttgtgagcct    300
 ggactggctt ccccggcctt ctacatgaac cccttcccgg tgctccatct catcgaggac    360
 ttgaggctgg ccttggagat gctggagctt cctcaggaga gagcag                   406



      <210> 462
      <211> 457
      <212> DNA
      <213> Homo sapiens


      <400> 462
 ggcacttccg ggtcgacgat ctcgtccggt gggcccgcgg aggaaagata ctggggaggg     60
 ggagccgcgg tgttcagagc gatgattccc ccacaggagg catccgctcg acggcgggag    120
 aatgaggaca agctgaagca ggaggaggag actctgtcct tcatccgaga cagcctggag    180
 aagagcgacc agctcactaa gaacatggtg gctatcgtat catcctttga gagccggctt    240
 atgaagctgg agaactccat catccctgtg cacaagcaga cggagaatct gcagcggctg    300
 caggagaatg ttgagaagac gctgacctgc ctggaccatg tcatcagcta ctaccatgtg    360
 gccagagaca ctgagaagat catcacagag ggccccacag gtaggctgga agagtacctg    420
 ggaagcatgg tcaagattca gaaggcagtg gagtatt                             457



      <210> 463
      <211> 839
      <212> DNA
      <213> Homo sapiens


      <400> 463
 gcagatgcca gtaccatgct tcctgtaaag cctgcagagc catgagccaa ttaaacctct     60
 tttctttaca gattacccag tcttgtggat catgagttca ggagatcgag accatcctgg    120
 ctcatacggt gaaaccccat ttttactaaa aatataaaaa attagccagg catggtggcg    180
 ggcgcctgta gtcccagcta ctcgggaggc tgaggcagga gaatggcatg aacccaggag    240
 gtggaggttg catagagccg agatcgcgcc attgcactcc agcttgggcg acagagcaag    300
 gctccgtctc aaaaaaaacc ccaaaaaacc aaaaaaccaa attacccagt ctcaggtatt    360
 tctttatagc aatccaagaa cggcctaata caatgggctc ccaacacata aaacatacag    420
 cagccacaaa ataattagaa acaatgttaa gtaatgccca ctaaattttg aatagcaaaa    480
 tatagcatag aagtataaaa caaatgtatt tcattatccc tacaaaaaaa ggggcatctt    540
 tttggttttg ttattgctgt ttgtataaaa actatggtgt gtgcatgtgg gtgtatgtgt    600
 attcccttat agaaaacttg aaaaatacag aggtaactta gaaagaatta ccttccccta    660
 ccagcctcag gatctcctga taccaattca ataaccactt aaaaacccac aggccaaacc    720
 tctctttagg ctctcaaata tctctactgt tgcctgtctc ccaggatgac acctagggct    780
 attaaggcta tgactctaat ctaaaacttt ttgttcttcc aattttaccc acgcgtccg     839



      <210> 464
      <211> 546
      <212> DNA
      <213> Homo sapiens


      <400> 464
 aaacggaaag gttcggaatt tgcctctgcg ccatctattt ttgcctgtta cctgtgacgt     60
 ccttggaagc agaatctgaa actttctgag gagagcattt gagcttcaga tttctaacag    120
 cctctttgca acaaaataga ccagtagctg aaggcaactg caatccttca tgatgtttcc    180
 cttggccaga aatgcactaa gcagtctcaa gattcaaagc attctgcaaa gcatggcaag    240
 acaataagcc atgtaaaaca ctttcaccag attttcatga taaatatggt aatgctgtgc    300
 tagccagtgg aactgccttt ctgtgttgca tacatgggtg tttacagcca ctcagattgg    360
 aatagaatgg aacctatccc ctgttggcag agttacccca aaagagtgga aacatcagta    420
 accatcacag ttgctgtaat gacagaattg tttaaaaaac caacttgtca tgtaagcact    480
 ctactgctta ttaaaatata gcacaattga aaaaataaaa tgtgttttaa atctttaaaa    540
 aaaaaa                                                               546



      <210> 465
      <211> 1213
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1213)
      <223> n = a,t,c or g


      <400> 465
 aggagtnnnn nnnnnnnnnn nnnnnnnnna caaacttcca ggactctagc cttcctggca     60
 acgccccccg aggccggact tccaggatcc agcctgtatt gaggatttga tgcgacggcc    120
 tcacggggct ttggagggga aagaggccca gagtagagag agagagagac cgacgtacac    180
 ggtatggcta cgggaacgcg ctatgccggg aaggtggcgg tcgtgacacg ggggcgggcg    240
 cggcatccgg agctgggatc gtgcgcgcct tcgtgaacag cggggcccga gtggttattt    300
 gcgacaagga tgagtctggg ggccgggccc tggagcagga agctccctgg aggctgtctt    360
 atatccttct gtgatgtgac tcaggaagat gatgtgaaga ccctggtttc tgagaccatc    420
 cgccgatttg gccgcctggg attgtgtttg tcaacaacgc tggccaccac ccacccccac    480
 agaggcctga ggagaccttc tgcccatgga ttccgccagc tgctggagct gaacctactg    540
 gggacgtaca ccttgaccaa gctcgccctc ccctacctgc ggaagagtca agggaatgtc    600
 atcaacatct ccacgcctgg tgggggcaat cggccaggcc caggcagttc cctatgtggc    660
 caccaagggg gcagtaacag ccatgaccaa agctttggcc ctggatgaaa gtccatatgg    720
 tgtccgagtc aactgtatac tccccaggaa acatctggac tccgctgtgg gaggagctgg    780
 cagccttaat gccagaccct agggccacaa tccgagaggg catgctggcc caggtagaag    840
 tggggttcag atccagccac tgggccgcat gggccagccc gctgaggtcg gggctgcggc    900
 agtgttccct ggcctccgaa gccaacttct gcacgggcat ttaactgctc gtgacggggg    960
 ggtgcagagc tggggtacgg gtgcaaggcc agtcggagca cccccgtgga cgcccccgat   1020
 atcccttcct gatttctctc atttctactt ggggccccct tcctaggact ctccccaccc   1080
 caaactccaa cctgtattca gatgcagccc ccaagccctt aggactctta aggcccagtt   1140
 taggcaaggt tgccgggttc acccttgcag gtttccctta aaaacgattt tggcagccag   1200
 gaaaaaaaaa aaa                                                      1213



      <210> 466
      <211> 811
      <212> DNA
      <213> Homo sapiens


      <400> 466
 gtcaggctgg tcttgaactc ctgacctcag gtgatccacc tgcctcagcc tcccaaagtg     60
 ctgggattac aggtgtgagc caccgtgcct gacctgtgtg attgttaaca tccccatctc    120
 ccaccaaaca ctggacttcc ctccttgggc ctgtgtctct cttttctgtt catgccatct    180
 ccctcagcac ccagcatagt gccagtgctt cacgggtgct gggttcatat ttgtcaagct    240
 gatgtttatc acacactttt aaagggtttt ttgtttttgt ttttgagaca gagtcccact    300
 ctgtcaccca ggctggagtg cagtggtgcc attttggctc actgcagagg tttctgcctc    360
 ccgggttcaa gcgattctcc tgcctcatcc tcctgagtag ctgggattac aggcacctcc    420
 caccacgcca ggctaatttt tgtattttca gtagagatgg ggtttcacca tgtttgccag    480
 gctggtctcg aactcctgac ctcaggtgat ccacccgcct cagcctccca aagtgctggg    540
 attacaggca tgagccacca cgcccagccc cctgctcaga tctttataag tggggccttc    600
 atgagagtct ctgagttgat ttttgtttcc tgccagacct tgctaaccta ccgaaccacg    660
 atgaccatcc cttcaggaga tggtctgtga aaatgcttaa agggaatggt ccaaatggga    720
 ggcagctttg ggtatggccc caaaatgact ctgctcctaa gttgtaactt tgaaactctg    780
 gttggactaa gtgaattcaa atgtagatca g                                   811



      <210> 467
      <211> 1825
      <212> DNA
      <213> Homo sapiens


      <400> 467
 acgccctgag atttgggcgg gtagcgattg ggggaaaaca ggcaacctaa gagttattac     60
 cgttagcagc gaagactgcg actaacgtca acgacggaga ctgcgtctgc cttcgcttcc    120
 gcctcgtagc cccgggaacc ggaaatccgt ctgccccggg tcacgtgctt aggagccata    180
 ttgtcgctag tggccgctgg ggctgggagg ggtgtgctag agaggcgcag cttctctggg    240
 cgtggttttt atcctggggg aaggatcggt ggaatgtgag gggaggtgga ggagatggcg    300
 gcgacagccc ggtgaagatg gcgccagcgg tcaagagcga ggtcagcggg gctgcgagca    360
 ctatgacaga ggatgtctcc taaaggcacc tctgctgtga caagctttat acttgccgct    420
 tgtgtcatga taacaatgaa gatcatcaac ctagatcgct ttaaagtgaa ggaagtgcag    480
 tgcataaact gtgaaaaaat tcaacatgcc caacagactt gtgaagaatg tagcacattg    540
 tttggagaat attattgcga tatatgccat ttgtttgaca aagataagaa gcagtatcac    600
 tgtgaaaact gtgggaattt gtaggaattt ggtccaaagg aaggtttttt cccttgtttg    660
 gaaatgttaa cttatggcct agctatgaat cttcaaggaa gacacaagtg tattgaaaat    720
 gtgtcccgac agaattgtcc aatatgtttg gaggacattc acacatcccg tgttgttgct    780
 catgtcttgc catgtggaca tcttttacat agaacgtgtt atgaagaaat gttgaaagaa    840
 ggctacagat gtccattatg tatgcactct gctttagata tgaccaggta ttggagacag    900
 ctggatgatg aagtagcaca gactcctatg ccatcagaat atcagaacat gactgtggat    960
 attctctgca atgactgtaa tggacgatcc actgttcagt ttcatatatt aggcatgaaa   1020
 tgtaagattt gtgaatccta taatactgct caagctggag gacgtagaat ttcactggat   1080
 cagcaatgac gagcctacac agtactggag aacttggcat tttctgatat agaaaaaggc   1140
 tttccttggt atcgtgttat ccatgtgtcg tcatctatgc attagagttg atgtgttttg   1200
 tactagtgtc cccagccata aaatccatat tacaagtacg taaggattcc agggtctctt   1260
 gatagacttt atcatagctc tatattgaat gaaagcccac tgtgcttgtg ttttgattgg   1320
 aaattccttt agtgtcagtt ttttggaagc caatgatgtt tgccactgat acattcatag   1380
 aagtgtatta tattttcatg aagctttgct ttaagtgacc actacgcgtt catttcattt   1440
 ctatttcttg atatgtactg cacttaattt tcgagtagta gtcttgactt tttaagggct   1500
 gtgttatatt aagttctccc ttactgttaa aacctaatta aatatgcttt agaatttttc   1560
 taagacagtc ctctggatcc tactaaatgt gaattttgat gtaataactg ctaataaaat   1620
 tatattgaaa cagtgcttta tagaaagttt tttccaaagt tttctatgtt tggctcaatt   1680
 agggcagtat catcagttct ataatgtaaa agaaattttc tttcttttga ggtattccat   1740
 aaaagtagtt gggaaaatta ttatgtaaaa taataagact cttccaaagc cttaataaaa   1800
 acatcaacat tgaaaacaaa aaaaa                                         1825



      <210> 468
      <211> 1523
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1523)
      <223> n = a,t,c or g


      <400> 468
 cggacgcgtg ggcagcgtcg gaagtggaag ctgaacctga ttgcagagtt ggagtccaga     60
 gttctggctg agcctgtccc tctgccagcc gagtgagtgc atggctgccc ccctagggcc    120
 tgttttactt gagttcaaca gcagagccct ggcttctgct ggccagcttg ccccttttgg    180
 tgggactttt agtcactgcc ttgacctcag gtgggagctc tcattatcag tcatctgttg    240
 ggcttgctgt tgacacctga ctgcccttgt gaagctacct gagaccgcct cctgacatat    300
 ggaggaaagt cttattttga gtcctgggtg tcaccctttt ttcaggtata gtaaacttat    360
 cctccacagg gcccaaggcc ctgtggctga gggcagataa tgtaggtctc accgtgaggt    420
 ggtcgtttga aaaagtgccc tgaatgattt gtctgctctc tccctagaat atgccctaca    480
 gagataggta tattcagcca cattttccat tcagggtagc aaacagtatg ccagatttgg    540
 cttgcagatg gggttttggc ccacatattt tttaaaattt cacataaaat attcattgag    600
 gagtccagat ttttagcctc tcttgtaaag ttggactctg gcagtgcaga tccacattcc    660
 cacatggcat caaagttccc ctttgaagag cacgcccttt gcctttctcc ttcacttgtc    720
 tggccctggt gggctgtgta gtctgccacc ctcaggggat tcgttttcca gccaaacctt    780
 gctcggccac tgttcttatc tccatgcagc ccaatggaac tgaaaaatct ggacgtatag    840
 gccacgtgaa ggtcaggggg tgctttgacc attccaagga gctgtatatg atgcccccga    900
 accatgggtg gaccttgtcg gggaggcccg ggagggcggc ctcatctcct cctcaactca    960
 gagtggggcc tatgtggtca ctcccttcca ctgcacccga ccttgggagt caccatcctg   1020
 gtaaaataga ggggttcgtt ccccaggaag aaagtgaatc cctgaaaccc cggcagaaag   1080
 gcccagattg agggagaagt ggaccctcat tgggatggtg aggcttgaca gtaaaccagg   1140
 gcagcctttt tgtccctgag aacaatccag aaaggaacca ctggccttat cgatacctgg   1200
 atagctatgg ccaagaatca cagggngcag agcccatctt cattgatgcc aacttccaga   1260
 gcacagtccc tgggaggacc cattggaggg caaaccagag ttactctgag ggaacgagca   1320
 tctgcagtac atcgtgacct ggtatggact ctctgcagct acgatcctac ctgtggttta   1380
 agaaattcct acgtgggaca acttggtgtg ttgacagatc agctgctgaa gccctgtccc   1440
 tggataattg cagtatttca agactgcctt tatgctggat catgtgctac tgggtataaa   1500
 gttctggcct tctaccttaa aaa                                           1523



      <210> 469
      <211> 1780
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1780)
      <223> n = a,t,c or g


      <400> 469
 actagttcta gatcgcgagc ggccgctcgc gatctataat gcctcttctg aagcagccat     60
 cccggcctct tggtactgct gaccccagcc aggctacagg gatcgattgg agctgtcctt    120
 ggggctgtaa ttggccccag ctgagcaggg caaacactga ggtcaactac aagccacagg    180
 ccccttcccc agcctcagtt cacagctgcc ctgttgcagg gatggcggtg gcctttcttg    240
 ttgctagacc gaagcctgtg ggatatacca aggcagagga gcccatagcc atgaggagcc    300
 tcggggccct gctcttgctg ctgagcgcct gcctggcggg gagcagcatg tcctgtgcca    360
 acgccggccg aaaacatcca agtgcaggaa aacttcaata tctcttcgga tctatgggga    420
 agtggtacaa cctgggccat cggtttccac cgtgcccctg gctgtaagaa agatcatggg    480
 acaggatgac agtgagcacg ctggtcttga gggagagggc gcttacagag gcggagatcc    540
 agcatggacc agcactcgtt ggccgggaaa ggtgttcttg ttgaggagac gtctttggag    600
 ctttattgaa gaaaaacaga tacttgattg gggaagtttt ctcttatcac aaatccaaat    660
 ggaacataac catgggagtc ctatgtgggt ccacaccaac tattgatgag tatgccattt    720
 tccttgacca aggaatttca gccgccatca tgggacccac ctttattgcc aagttttacg    780
 ggcgggcgcc gcaggctgag ggaaactctc ctgcaggact ttcagagtgg ttgcccaggg    840
 gtntgggcat tcctgaggac tcccttcttc accatggctg accgaggtga aatgtgtccc    900
 tgggggagca ggaaccaaaa agccatcttt aatcccgaga gtccggaggc ttgttgctta    960
 ccccaagaag gagggaagga tccagggggg tgggcaaact ggtaaactga aagtccccaa   1020
 gaaaagaagg atttccttgc cagctgggct tacttcggcc ggtcccctgc aatgggaaat   1080
 gacccagcag gtaatttcct aataatggta acatcccatg gccctgtgaa gaactttccc   1140
 agtacggcgg ctgcatgggg caacgggtaa acaactttcg tcaacaagaa aaggagtgtc   1200
 tgcagacctg cccgaacttg tgggcggccc tgcaatctcc cccatagtcc cgggggcccc   1260
 tgccgagcct tcatcccagc tctggggcat ttgatgctgt tcaaggggga agtgcgtcct   1320
 gcattcccct tacgggggcc tagccagggg caacggggaa caagttctac ttcagagaag   1380
 gagtgcagag agtactgcgg tgtccctggt gatggtgatg aggagctgct gcgcttttgc   1440
 caactgacaa ctggccggtc tgcaaagtca gaggatggcc agtgtctgtc ccggggtcct   1500
 gtggcaggca agcgccaaag caacctgggg tccaaataaa aactaaattg taaactcctg   1560
 tgnnaaggnn gaccacnnaa naaaaggggg ggggcccttt ttaaagaacc cttggggggc   1620
 ccaaatttta ccggggatgg caaggtttta tttttttcct tttggggggg ctttttaaaa   1680
 ccatcctggg attttttgga aagaaccctt ttttttgggg ggggacaaat ttggccaacc   1740
 tcccctccaa aatttaaacc cttaagggaa aattaaaatt                         1780



      <210> 470
      <211> 2555
      <212> DNA
      <213> Homo sapiens


      <400> 470
 gccgtgcggg tccgggattc ccagccatgg cagattcctc cgggcagcag ggcaaaggcc     60
 ggcgtgtgca gccccagtgg tcccctcctg ctgggaccca gccatgcaga ctccaccttt    120
 acaacagcct caccaggaac aagtgtttct tgcatttctt gtgatcgtca ttccttcatt    180
 cctaacaaag gaagtgttca tacctcaaga tgggaaaaag gtgacgtggt attgctgtgg    240
 gccaaccgtc tatgacgcat ctcacatggg gcacgccagg tcctacatct cttttgatat    300
 cttgagaaga gtgttgaagg attacttcaa atttgatgtc ttttattgca tgaacattac    360
 ggatattgat gacaagatca tcaagagggc ccggcagaac cacctgttcg agcagtatcg    420
 ggagaagagg cctgaagcgg cacagctctt ggaggatgtt caggccgccc tgaagccatt    480
 ttcagtaaaa ttaaatgaga ccacggatcc cgataaaaag cagatgctcg aacggattca    540
 gcacgcagtg cagcttgcca cagagccact tgagaaagct gtgcagtcca gactcacggg    600
 agaggaagtc aacagctgtg tggaggtgtt gctggaagaa gccaaggatt tgctctctga    660
 ctggctggat tctacacttg gctgtgatgt cactgacaat tccatcttct ccaagctgcc    720
 caagttctgg gagggggact tccacagaga catggaagct ctgaatgttc tccctccaga    780
 tgtcttaacc cgggttagtg agtatgtgcc agaaattgtg aactttgtcc agaagattgt    840
 ggacaacggt tacggctatg tctccaatgg gtctgtctac tttggataca gcggaagttt    900
 tgcttctagc ggagaagcac tcctatggga agctggtgcc tgaggccgtt ggagatcaga    960
 aagcccttca agaaggggaa ggtgacctga gcatctctgc agaccgcctg agtgagaagc   1020
 gctctcccaa cgactttgcc ttatggaagg cctctaagcc cggagaaccg tcctggccgt   1080
 gcccttgggg aaagggtcgt ccgggctggc atatcgagtg ctcggccatg gcaggcaccc   1140
 tcctaggggc ttcgatggac attcacggag gtgggttcga cctccggttc ccccaccatg   1200
 acaatgagct ggcacagtcg gaggcctact ttgaaaacga ctgctgggtc aggtacttcc   1260
 tgcacacagg ccacctgacc attgcaggct gcaaaatgtc aaagtcacta aaaaacttca   1320
 tcaccattaa agatgccttg aaaaagcact cagcacggca gtttgcggct ggcctttcct   1380
 catgcactcg tggaaggaca ccctggacta ctccagcaac accatggagt cagcgcttca   1440
 atatgagaag ttcttgaatg agtttttctt taaatgtgaa agatatcctt cgcgctcctg   1500
 ttgacatcac tggtcagttt gagaagtggg gagaagaaga agcagaactg aataagaact   1560
 tttatgacaa gaagacagca attcacaaag ccctctgtga caatgttgac acccgcaccg   1620
 tcatggaaga gatgcgggcc ttggtcagtc agtgcaacct ctatatggca gcccggaaag   1680
 ccgtgaggaa gaggcccaac caggctctgc tggagaacat cgccctgtac ctcacccata   1740
 tgctgaagat ctttggggcc ggtagaagag gacagctctc tgggatttcc ggttcgtatg   1800
 ggctggtaac atgcctcagt ttcgaggcca cagtcatgcc taccctctag gtgtaatcag   1860
 gattccgaga aggagtgcgg gaagattgcc cgagcagcaa aaagtccttg agattctgca   1920
 gctcagcgat gccctgcggg acaacatcct gccccgagct tggggtgcgg tttgaagacc   1980
 acgaaggacc tgcccacagt ggtgaaacct ggtagacaga aacaccttat taaaagagag   2040
 agaagaaaag agacgggttg aagaggagaa gaggaagaag aaagaggagg cggcccggag   2100
 gaaacaggaa ccaagaaggc agcaaagctg gcccaagatg aagattcccc ccccagtgag   2160
 atgttccttg tcagaaaccg acaaataact ccaaagtttg atgaaaatgt aagcatggtc   2220
 tgccccacac atgacatgga gggcaaaaga gctcagcaaa gggcaagccc aagaagctga   2280
 agaagctctt cgaggctcaa ggagaagctc ttacagagga atatctgcag atggcccaga   2340
 atggaagctt ccagtgaggg gggcacagga ctgacttttt aaaaccattg tggactagtg   2400
 gctgctgtct gcctcagtga caatgtccca gcgctcctat catgtttaca gtcacccttg   2460
 gggtcctaaa ttaagagttg tgttcatgta ggttcgtgtc gtccgttggc tctgagacat   2520
 tgataataaa tttttctcaa cagtgaaaaa aaaaa                              2555



      <210> 471
      <211> 2401
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2401)
      <223> n = a,t,c or g


      <400> 471
 gtttttatga ggatttatca acagagttat ttaaggagga atcctgtgtt gttatcagga     60
 actaaaagga taaggctaac aatttggaaa gagcaactac tctttcttaa atcaatctac    120
 aattcacaga taggaagagg tcaatgacct aggagtaacc attcaactcc aagattcatt    180
 ttcattatgt tattcatgga acacccggag ccagctcgga ggcggttgaa taatagctct    240
 tcaagtctgc aataaaaaaa tggcctccaa catgaactac attgcagaaa atgggaaaaa    300
 aaacagaatg gaaaagagta aaaaagttca agcaggcaga tcctcgaaga atttgtccgt    360
 ggaaaaagta ctagatcgac gtgttagttg aatgggaaag tggaaatatt tccctgaagt    420
 gggaagggat ttacagatgc tgacaatact tggggaaccc tgaaggaaaa tttaggattg    480
 tcccagaatt ggattgaagc cgtttcttaa acttctccag gaaagctggg caaagaaaaa    540
 agattggtac caaaaaggaa aatcttttat ctgaccagtg aatctggatt gaccagccaa    600
 attcatagaa gaaaaagaga tgctgctgac caacccaaag aggatttgcc ccggaggtct    660
 tgatccctga aagaataatt tgggtgcccc cagacagcca gttggagaat ttgatgtttc    720
 tcatggaaat ggaaaagatt ccagatgagg cagacttggt gcctgggcga aaagaggcac    780
 atatgaagtg tcctcaaatt tgtaatttgc tttttatgaa gagagactaa cttgggcatt    840
 cttgtccgag aagatgaagc tcaataattg ttcacattgt tcttttatat atatttatat    900
 atatatatta aaaattgggt cttagatttt gatttactag tgtgacaaaa taactacatc    960
 ctaatgaaaa tcaagtttgg atatgtttgt tttgaaagta gccgttggaa gagttgttgg   1020
 tgggtttttt gcatccatag cactggttac tttgaacaaa taaataaaag ctttctgtag   1080
 ttgcttcctt tatcaggaaa aggaacattt ggataccatg gtattatcca tttcctcttc   1140
 cattaaagga acagcttttc taaatgttgg gggaaatgtc catagtcatt actcagtcaa   1200
 aacttgtgtt ctcatggagc ctaaggacca ttctagattt attacgtgtt ttttgtgtgt   1260
 gtgtgtgtgt gtgtgtgtgt gtgtgtatcc ataaaatgca tatgtaaatt ttttttttgt   1320
 ttttaagcat tcacccaaac aaaaaaatca caggtaaacc catgtttctg agatgccatt   1380
 attccaagca aaataagaga taatcccttc aagttaaatt gaaaattttc ctgaaaccat   1440
 acatttcaag tgaaataagt aattctagat aggacaattt aaattggata attttaaagt   1500
 gtctataatt gccagtggtt tatttgcaaa attccctaaa aggggaaaat ttttatccac   1560
 tgcccatcac agccaggttc cctccatccc agatggagga aacctaggac aaaatgccaa   1620
 gtgtgtttta actagcttaa acaaaaacta aagttaaaat ggaacattta aaaagttttc   1680
 cctagcgggg gcccattccc ttagccaaaa atgttgggaa tccccctgtg gcctacattg   1740
 aacctaaaag ggtcatggat gaatgggaaa tatgtaaaga ctttgggctc attagaaacc   1800
 ttaaatcaga tgggttagag ggtgtttggc agtttaggga cctgctggtc ataaatgtgt   1860
 gaacaacctt ttggtaacct taacctattg gacctggcat gtttttttct ttacccccaa   1920
 ttcattacga tggaggctca aatcttgagt ttgctttact ggttcagcaa aagccaggga   1980
 aggaacaact ttgtagtaat ccaaaatgtt atccaactgg tatattgttt acgtttattg   2040
 taaatactgg gtgaacaagt gggttaataa atagttttat attcctttat gcnnnnnnnn   2100
 nnnnnggcct tcccccaggg gttttttttg ttgccaccct taggggacca aaaaagggcc   2160
 ccctgggggt taaacaaagg ccctggtgaa agggatccac cccccccgcc ctttggggaa   2220
 accctgggga acggggccaa aaaaacaggg gccccaaacc cccaaggggc gatttttaat   2280
 ttggggcccg ccccccagaa ccggggggcc ccaaggggcc cctttttcct ggttccccgg   2340
 ggggaaaagg gaaaaaggaa ttcgggccct ggggttttcc caagaaaagt tgcagggaca   2400
 a                                                                   2401



      <210> 472
      <211> 2278
      <212> DNA
      <213> Homo sapiens


      <400> 472
 tcccgaccgg cccgcggcag cctgcgccgc gccatggcca cctccccgca gaagtcgcct     60
 tctgtcccca agtctcccac tcccaagtcg cccccgtccc gcaagaaaga tgattccttc    120
 ttggggaaac tcggagggac cctggcccgg aggaagaaag ccaaggaggt gtccgagctg    180
 caggaggagg gaatgaacgc catcaacctg cccctcagcc caattccctt tgagctggac    240
 cccgaggaca cgatgctgga ggagaatgag gtgcgaacaa tggtggatcc aaactcacgc    300
 agtgacccca agcttcaaga actgatgaag gtattaattg actggattaa tgatgtgttg    360
 gttggagaaa gaatcattgt gaaagaccta gctgaagatt tgtatgatgg acaagtcctg    420
 cagaagcttt tcgagaaact ggagagtgag aagctaaatg tggctgaggt cacccagtca    480
 gagattgctc agaagcaaaa actgcagact gtcctggaga agatcaatga aaccctgaaa    540
 cttcctccca ggagcatcaa gtggaatgtg gattctgttc atgccaagag cctggtggcc    600
 atcttacacc tgctcgttgc tctgtctcag tatttccgcg caccaattcg actcccagac    660
 cagtgtttcc atccaagtgg ttgtggtcca gaaacgagaa ggaatcctcc agtctcggca    720
 aatccaagag gaaataactg gtaacacaga ggctctttcc gggaggcatg aacgtgatgc    780
 ctttgacacc ttgttcgacc atgccccaga caagctgaat gtggtgaaaa agacactcat    840
 cactttcgtg aacaagcacc tgaataaact tgaacctgga ggtcacaaga actggaaacc    900
 cagtttgcaa gatggggtgt acctggtgct gctcatgggg ctcctgaagg gctacttttg    960
 tgcccttgcc cagttttttc ctgaccccgg acagctttga acagaaggtc ttgaatgtct   1020
 cctttgcctt tgaagcttca tgcaagatgg gagggttggg aaaagccaaa accgcggcca   1080
 gaagacatag tcaactgtga cctgaaaatc tacactacga gtgttgtaca aacctcttca   1140
 cccaagtacc gtaacgtgga gtgaggggct gccctgggcc caccactgcc ccaagagttc   1200
 ttgctgttgg cgtactggac cctcctccga actgccttac cctgcttaat tcctgtctct   1260
 tgcactgtgc tctcccacaa gtccagctgc aacccagaga aaagtggaaa ctgaaattag   1320
 gaaggaaatc atcaataact cagtgggctg acccatccct cccaggcgct ggggaccaac   1380
 ctagcaatga aggttgggaa ggttgtttcc cttcccggtg ccaggtccag atttcccttc   1440
 catgattttg ggaaccaggt taggcaaagg agtccccaca agttgaaatt aaggatccta   1500
 gttaccattc aaaggatgct aactgtgtgt caggccccac actaagtgct ctgctctgat   1560
 atactcaagg ccattaatct tcaggactcc cattgacgta ggtgtttcat tcccctttta   1620
 cagatgagga aactaaggct tggaggttaa atgacttgcc agaagttgga atttttttcc   1680
 tctttgaaca taacctctcc cttctcccta aaggtaacca ctattctgag tccaatcatc   1740
 aaggttttgc ttttcttttt agctaagtat gcattcctca atagtagaca gtacaacatg   1800
 tttataacaa gccaattaca ttatgttctt tgcatgttct aaagtgtgtg tatgttgtgt   1860
 gcacatctgg agcacgtgca catgtacacc tgagccaaaa acacagagaa cccactgatc   1920
 tcaccactgg ggcaagctag gtcagagctt agtgattcac actgaaattg gcaaattgga   1980
 tttaacccaa ttaatagtgt gtgtgtggca ggagtcatgt ccctccacat ccctttgtac   2040
 aaatggagaa ttactcttaa ttcccttcca gaatttataa taactcctgt tactttggtt   2100
 tcagggtgac atttggggaa ggattttgtt taggaattaa tgggagtggg cacattttgc   2160
 agcctttttg cttggattgc atgtaatggg aaatgcccta tattttcctg gcaaaataag   2220
 gtactaaatt tcatttattc gttaaggcaa atgtaccatt ttgctcaggg caccggag     2278



      <210> 473
      <211> 1001
      <212> DNA
      <213> Homo sapiens


      <400> 473
 tcggtgcgaa ttccgtggcg cgagggatcc tgaggctgct ccagcagtgc gccgccgccg     60
 tctcctgggg cggcttgggt tagccgggag gtgggtcaga ggctcgcccc gtgccctgcg    120
 tccgggcgtc tccttagggc gcgtcttcgg gtccggccag cggtgctgaa aaagggagaa    180
 ggttgggggt agggaggaaa caagatccca gttcaataga tttctccgca gatcctgtgc    240
 cttcaaaccc tacgagtgca tactttaaaa caaaatcgaa cgaaagaagg cttaaggaac    300
 tagagagtcg cctgcaacaa gtggatggat ttgaaaagcc caagctactt ctggaacagt    360
 atcctaccag gccgcacatt gcagcatgta tgctctatac aatccataac acttatgatg    420
 acattggaga ataaagtcgt tgcacatcta ggatgtgggt gtggagcact tagcatcaga    480
 actgcaatgt taagagcagg ggtgtgtgtt ggatttgaca tatatgaaga cgcattggaa    540
 atatttaata ggaacgcaga agagttttga gttaacaaat attggacatg gttcaatgtg    600
 gatgtgtgcc ttattatcct aacagaatgt ccaagtcatt cgatacagta attatgaatc    660
 cctccctttg ggacccaaaa ataataaagg gacagatatg gcttttctaa agactgcttt    720
 ggaaatggca agaacagcag tatattcctt acacaaatcc tcaactagag aacatgttca    780
 aaagaaagct gcagaatgga aaatcaagat agatattata gcaggtggct tttgttttac    840
 agaacttcga tatgacctgc cagcatcata caagtttcac aaaaagaaat cagtggacat    900
 tgaagtggac ctaattcggt tttcctttta aaagccccgc aaacaaaagt cgtttaaaac    960
 ctatttaaaa tgaataaacc attggtttac taaaaaaaaa a                       1001



      <210> 474
      <211> 1658
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1658)
      <223> n = a,t,c or g


      <400> 474
 cattgacccc ccttttgaga gcactacgga agngcggcgg aannccccgg ccggaagccg     60
 ctgtcgggga gccggcggtg gggctggacg caggtgcaac tgacatgggt gaaccccagg    120
 gatccatgcg gattctagtg acagggggct ctgggctggt aggcaaagcc atccagaagg    180
 tggtagcaga tggagctgga cttcctggag aggactgggt gtttgtctcc tctaaagacg    240
 ccgatctcac gtggctggcc tggcctgggt gtgcttggct gtgttcctgg aaaaacaaac    300
 cccctcccat ctcttcctgg aagcctgcac cctcatatca gccaggccct ggggccaccc    360
 tcccttttga ctgtccctcc tgccatagtc ccacccagat cctgcacttg gcacccaacc    420
 ctggtggtgc tggttccctc cagagcctcc tgacagcctg gctttctaca aggatacagc    480
 acagacccgc gccctgtttg agaaggtcca acccacacac gtcatccatc ttgctgcaat    540
 ggtggggggc ctgttccgga atatcaaata caatttggac ttctggagga aaaaacgtgc    600
 acatgaacga caacgtccct gcactcggcc ttcgaggtgg gcgcccgcaa aggttggtgt    660
 cctgcctgtc cacctgtaat cttcccttgg acaaagacgg acctaccccg attaagattg    720
 aggacccatg attccacaat gggcctcccc acaacagcag agtatgggta ctcgtatgcc    780
 gaagaagatg atcgacgtgc agaacagggg cctacttcca gcagtacggg atgcaccttc    840
 accgctgtca tccccaccaa cgtcttcggg ccccacgaca acttcaacat cgaggatggc    900
 cacgtgctgc ctggcctcat ccacaaggtg cacctggcca agagcagcgg ctcggccctg    960
 acggtgtgtg ttccgggaaa tccgcggagc cagttcatat aattcgctgg acctggcccc   1020
 agctctttat ctgggtcctg cggggagtac aatgaagtgg agcccatctt ccctctcggt   1080
 gggcgaggaa gatgaggtct ccattcaagg aggcagccga aggcggtggt ggaggccaat   1140
 ggactttccc atggggaagt caccttttga tacaaccaaa gtcgggatgg gcagtttaag   1200
 aagacaagcc agtaacagca agttgaggac ttaccttgcc cggatttccc ggttcacacc   1260
 cccttcaagc aaggcggtga aggagaacct gtgctttggt tcacttgaca aacttacgag   1320
 caggcccgga agttgaagct ggaagacagg atcaggtgcc agcggaccat cggcctggca   1380
 gaagcccagc gggccaccca cccgtcaaac cttgcaagga gctgagggca ccacccaagc   1440
 aacctgggcc tgcattccag tccgctctgc aagccccaaa gcatctttcc aagtggggcc   1500
 ccccatttca cgttggttcc ttcagggaaa ccaggggttc cggggcaggc ccggcggttt   1560
 ttgttcccca caccagcccc ctgcgcgtgt ccactctgat cctgcatccc actccctggg   1620
 agccaataaa gtgcattttc acaggcaaaa aaaaaaaa                           1658



      <210> 475
      <211> 3432
      <212> DNA
      <213> Homo sapiens


      <400> 475
 gaattcccgg gtcgacgatt tcgtgtggca gcagcgttgg cccggccccg ggagcggaga     60
 gcgaggggag gcggagacgg aagaaggtct gaggagcagc ttcagtcccc gccgagccgc    120
 caccgcaggt cgaggacggt cggactcccg cggcgggagg agcctgttcc cctgagggta    180
 tttgaagtat accatacaac tgttttgaaa atccagcgtg gacaatggct actcaagctg    240
 atttgatgga gttggacatg gccatggaac cagacagaaa agcggctgtt agtcactggc    300
 agcaacagtc ttacctggac tctggaatcc attctggtgc cactaccaca gctccttctc    360
 tgagtggtaa aggcaatcct gaggaagagg atgtggatac ctcccaagtc ctgtatgagt    420
 gggaacaggg attttctcag tccttcactc aagaacaagt agctgatatt gatggacagt    480
 atgcaatgac tcgagctcag agggtacgag ctgctatgtt ccctgagaca ttagatgagg    540
 gcatgcagat cccatctaca cagtttgatg ctgctcatcc cactaatgtc cagcgtttgg    600
 ctgaaccatc acagatgctg aaacatgcag ttgtaaactt tgattaacta tcaagatgat    660
 gcagaacttg ccacacgtgc aatccctgaa ctgacaaaac tgctaaatga cgaggaccag    720
 gtggtggtta ataaggctgc agttatggtc catcagcttt ctaaaaagga agcttccaga    780
 cacgctatca tgcgttctcc tcagatggtg tctgctattg tacgtaccat gcagaataca    840
 aatgatgtag aaacagctcg ttgtaccgct gggaccttgc ataacctttc ccatcatcgt    900
 gagggcttac tggccatctt taagtctgga ggcattcctg ccctggtgaa aatgcttggt    960
 tcaccagtgg attctgtgtt gttttatgcc attacaactc tccacaacct tttattacat   1020
 caagaaggag ctaaaatggc agtgcgttta gctggtgggc tgcagaaaat ggttgccttg   1080
 ctcaacaaaa caaatgttac cttcttggct attacgacag actgccttca aattttagct   1140
 tatggcaacc aagaaagcaa gctcatcata ctggctagtg gtggacccca agctttagta   1200
 aatataatga ggacctatac ttacgaaaaa ctactgtgga ccacaagcag agtgctgaag   1260
 gtgctatctg tctgctctag taataagccg gctattgtag aagctggtgg aatgcaagct   1320
 ttaggacttc acctgacaga tccaagtcaa cgtcttgttc agaactgtct ttggactctc   1380
 aggaatcttt cagatgctgc aactaaacag gaagggatgg aaggtctcct tgggactctt   1440
 gttcagcttc tgggttcaga tgatataaat gtggtcacca tgtgcagctg gaattctttc   1500
 taacctcaca ttgcaataat tataagaaca agatgatggt ctgcccaaag tggggtgggt   1560
 ataagaggct tctcgtgcgt aactggtcct tcgggctggt ggacaaggga agacatcact   1620
 tgagcctgcc atctgtgctc ttcgtcatct tgaccagccc gacaccaaga agcaagagat   1680
 ggcccagaat gcagttcgcc ttcactatgg actaccagtt gtggttaagc tcttacaccc   1740
 accatcccac tggcctctga taaaggctac tgttggattg attcgaaatc ttgcccttat   1800
 gtcccgcaaa tacatgcacc tttgcgtgag cagggtgcca tttccacgac tagttcagtt   1860
 gcttgttcgt gcacatcagg atacccagcg ccgtacgtcc atgggtggga cacagcagca   1920
 atttgtggag ggggtccgca tggaagaaat agttgaaggt tgtaccggag cccttcacat   1980
 cctagctcgg gatgttcaca accgaattgt tatcagagga ctaaatacca ttccattgtt   2040
 tgtgcagctg ctttattctc ccattgaaaa catccaaaga gtagctgcag gggtcctctg   2100
 tgaacttgct caggacaagg aagctgcaga agctattgaa gctgagggag ccacagctcc   2160
 tctgacagag ttacttcact ctaggaatga aggtgtggcg acatatgcag ctgctgtttt   2220
 gttccgaatg tctgaggaca agccaccaag ataacagaaa acggttttca gttgagctga   2280
 ccagctctct cttcagaaca gagccaatgg cttggaatga gactgctgat cttggacttg   2340
 atatttggtg cccaggggag aaccccttgg gatatcgcca ggatgatcct agctatcgtt   2400
 cttttcactc tggtggatat ggccaggatg ccttgggtat gggaccccat gatggaacat   2460
 gagattggtt ggccaccacc ctggtgcttg actatccagt tgatgggctg ccagataatg   2520
 gggcatgccc aggacctcat ggatgggctg cctccaggtg acagcaatca gctggcctgg   2580
 tttgatactg acctgtaaat catcctttag ctgtattgtc tgaacttgca ttgtgattgg   2640
 cctgtaaagt tgctgagagg gctcgagggg tgggctggta tctcagaaag tgcctgacac   2700
 actaaccaag ctgagtttcc tatgggaaca attgaagtaa actttttgtt ctggtccttt   2760
 ttggtcgagg agtaacaata caaatggatt ttgggagtga ctcaagaagt gaagaatgca   2820
 caagaatgga tcacaagatg gaatttagca aaccctagcc ttgcttgtta aaattttttt   2880
 tttttttttt ttaagaatat ctgtaatggt actgactttg cttgctttga agtagctctt   2940
 tttttttttt tttttttttt ttttttttgc agtaactgtt ttttaagtct ctcgtagtgt   3000
 taacgttata gtgaatactg ctacagcaat ttctaatttt taagaattga gtaatggtgt   3060
 agaacactaa ttaattcata agcactcgta gttgagtgta atctgaataa agtgtaacaa   3120
 tgtgtgtagc ctttttgtat aaaatagaca aatagaaaat ggccccatta ggttcccttt   3180
 ttaatatgct taaaataagc aggtggatct atttcatgtt tttgatcaaa aactatttgg   3240
 gatatgtatg ggtagggtaa atcagtaaaa ggtgttattt tggaaccttg tgtttggaca   3300
 gtttaccagt tgccttttat cccaaagttg gttgtaacct gcctgtgata cgatgcctcc   3360
 aagaggaaaa tgcgggttta taaaaaaatg ggttcaggat ttaaaacttt ttaattcatt   3420
 cgaaaaaaaa aa                                                       3432



      <210> 476
      <211> 4127
      <212> DNA
      <213> Homo sapiens


      <400> 476
 agactggggt gggggagggg ttcaggcctg ttccccgcgg ctgcggcagc accagggccg     60
 gccgccaccg cctctagaac gcggaggagg tgggtcctgg gaagcgggat gtccatcgct    120
 ccagcttgtt ggtgaatgct gaggagagtc actgttgctg cagtctgtgc cagcccggag    180
 gaagttgtgt gaggccgggc gggagctcgc ggcgctctgg ggaatcgaaa cgcggggtcg    240
 gtgcgaagac tctgctgctg ccagaccctt tcctattctg gccatgcctg gagaggaaca    300
 aggcgaagtc tacctgcagc tgccctgacc tgcagcccaa tggacaggat ctgggcgaga    360
 acagccgggt tgcccgtcta ggagcggatg aatctgagga agagggacgg agggggtctc    420
 tcagtaatgc tggggaccct gagatcgtca agtctcccag cgaccccaag caataccgat    480
 acattcaaat tacagaatgg cttgcaggca cttctgattt cagacctaag taatatggaa    540
 ggtaaaacag gaaatacaac agatgatgaa gaagaagagg aggtggagga agaagaagaa    600
 gatgatgatg aagattctgg agctgaaata gaagatgacg atgaagaggg ttttgatgat    660
 gaagatgagt ttgatgatga acatgatgat gatcttgata ctgaggataa tgaattggaa    720
 gaattagaag agagagcaga agctagaaaa aaaactactg aaaaacagtc tgcagcggct    780
 ctttgtgttg gagttgggag tttcgctgat ccagatgacc tgccggggct ggcacacttt    840
 ttggagcaca tggtattcat gggtagtttg aaatatccag atgagaatgg atttgatgcc    900
 ttcctgaaga agcatggggg tagtgataat gcctcaactg attgtgaacg cactgtcttt    960
 cagtttgatg tccagaggaa gtacttcaag gaagctcttg atagatgggc gcagttcttc   1020
 atccacccac taatgatcag agatgcaatt gaccgtgaag ttgaagctgt tgatagtgaa   1080
 tatcaacttg caaggccttc tgatgcaaac agaaaggaaa tgttgtttgg aagccttgct   1140
 agacctggcc atcctatggg aaaatttttt tggggaaatg ctgagacgct caagcatgag   1200
 ccaagaaaga ataatattga tacacatgct agattgagaa gaattctgga tgcgttacta   1260
 ctcttctcat tacatgactt tagtggttca atccaaagaa acactggata ctttggaaaa   1320
 gtgggtgact gaaatcttct ctcagatacc aaacaatggg ttacccagac caaactttgg   1380
 ccatttaacg gatccatttg acacaccagc atttaacaaa ctttatagag ttgttccaat   1440
 cagaaaaatt catgctcctg accatccaca tggggcactt ccttcctcaa ccagcaacat   1500
 taccaggggt gaagccactt cattatatat cctggccggg ttggaccttg aaggcaaagg   1560
 cagcattctt tctttcctta ggaaaaaatg ctgggctctt gcactgtttg gtggaaatgg   1620
 tgagacagga tttgagcaaa attctactta ttcagtgttc agcatttcta ttacattgac   1680
 tgatgagggt tatgaacatt tttatgaggt tgcttacact gtctttcagg atttaaaaat   1740
 gctgcagaag ctaggcccag aaaaaagaat ttttgaagag attcggaaaa ttgaggataa   1800
 tgaatttcat taccaagaac agacagatcc agttgagtat gtgggaaaac atgtgtgaga   1860
 acatgcagct gtacccattg caggacattc tcactggaga tcagcttctt tttgaataca   1920
 agccagaagt cattggtgaa gccttgaatc agctagttcc tcaaaaagca aatcttgttt   1980
 tactgtctgg tgctaatgag ggaaaatgtg acctcaagga gaaatggttt gggaactcaa   2040
 tatagtatag gaagatattg aaaactcttg gggctgaact gtgggaatag taatttcgaa   2100
 ttaaatccag atctttcatc ttccagctgg aaaacaagta cataggccac gggactttac   2160
 gttggagggc tttcggtttg ccccggaaac agaataccca gttaaaattg tgaatactcc   2220
 acaaggctgc ctgtggtata agaaagacaa caaattcaaa atccccaaag catatatacg   2280
 tttccatcta atttcaccgt tgatacagaa atctgcagca aatgtggtcc tctttgatat   2340
 ctttgtcaat atccttacgg cataaccttg cgggaaccag cttatgaagc agatgtgggc   2400
 acagctggga gtattaaact ggtagctggg agaacatggt ttaattattc gagtgaaagg   2460
 atttaaccac aaactacctc tactgtttca gctcattatt gactacttag gctgagtttc   2520
 aattccacac cagctgtctt tacaatggat aactgagcag ttgaagaaga cctactttta   2580
 acatcctcat caagcccgag actttggcca aagatgtacg gcttttaatc ctgggaatat   2640
 gcccgttggt ctatgattga caagtaccag gctttgatgg acggcctttc ccttgagtct   2700
 ctgctgagct tcgtcaaaga attcaaatcc cagctctttg tggagggcct ggtacaaggg   2760
 aatgttcaca agcacagaat ctatgggatt tcctgaaata tgttgttgga caaactaaac   2820
 tttcaagcct ctgggagcag ggagatgcct gttgcagttt ccagggttgt agagctgccc   2880
 agtggcccac cattctaatg caaaagtgaa aagcttttga accagggtta tggccaactt   2940
 tggaagtcac tgtgtactac cagtcaggta cccaggagtc taagaggaat atacgcttat   3000
 ggagctgctt gtgatgcaca tgggaaggaa ccttgttttg acttccttcc gaaccaagca   3060
 gacccttggg tacctatgtc tacccctacc ctgtagggaa cacatcgggg gtattttagg   3120
 attttcttta cgctggggag accggcacac gcaattacaa ttctgaaagt tgttgaataa   3180
 gaaagataga agagtttctt tctagctttg aggggaaaaa ttgaggaccc tttattgaaa   3240
 agggcattca accaccccag gtcaccagct ctcgatcaag ctgaagggag tgtgaggata   3300
 cccccaccct tgggggaagg aaggtggaat aggaaactgg gaatgaaagt ggttaacacc   3360
 agacagtacc ctcctttgaa ccgcccttgc ccccacgaga ttgaagccac tgaaagtcat   3420
 tcctcaaaat ccagaccctg gtcaactggg ttcaaagccc atagagggcc ccggaagtaa   3480
 aatgcctcag cgttcatgtg agttgttgga tatgggaagt atgaactgga agaggatggt   3540
 cccccctctt agtgaggatt caaattcttc ttgtgaagtg atgcagctga cctacctgcc   3600
 aacctctcct cttgctgggc agattgtatt catccccatt tattgatgtt cagggctttt   3660
 cacaacaaca ctcaaccttc tcccctacca taaaatagtc aaataaaata aaactgcagt   3720
 ccacgttggc cctgaagcaa tgtgtatttt aaaatgtgtt tgtttgtatt ttatggagtt   3780
 agttatacta ctgccttagg gcttccattg aagttttgca ctggcatcat agcatttgat   3840
 ttacttttta tcctttgttg agactaataa acccagggtt actgtaggag ctggcaaagg   3900
 aaaattagca gaatgggcca agcgagacca gaaagcctgc agcagcactt tgagaagccc   3960
 tggcctgtgt cctctcagac tgagaatcta cttcttgaaa ggccttacgt aaccagtata   4020
 ttgaataact aactaaatgc taggtactaa tacctgtttt tttaatgtat ttttaaataa   4080
 aaaagatgat agatagatag atagatatag ttctgtattt cccttca                 4127



      <210> 477
      <211> 4127
      <212> DNA
      <213> Homo sapiens


      <400> 477
 agactggggt gggggagggg ttcaggcctg ttccccgcgg ctgcggcagc accagggccg     60
 gccgccaccg cctctagaac gcggaggagg tgggtcctgg gaagcgggat gtccatcgct    120
 ccagcttgtt ggtgaatgct gaggagagtc actgttgctg cagtctgtgc cagcccggag    180
 gaagttgtgt gaggccgggc gggagctcgc ggcgctctgg ggaatcgaaa cgcggggtcg    240
 gtgcgaagac tctgctgctg ccagaccctt tcctattctg gccatgcctg gagaggaaca    300
 aggcgaagtc tacctgcagc tgccctgacc tgcagcccaa tggacaggat ctgggcgaga    360
 acagccgggt tgcccgtcta ggagcggatg aatctgagga agagggacgg agggggtctc    420
 tcagtaatgc tggggaccct gagatcgtca agtctcccag cgaccccaag caataccgat    480
 acattcaaat tacagaatgg cttgcaggca cttctgattt cagacctaag taatatggaa    540
 ggtaaaacag gaaatacaac agatgatgaa gaagaagagg aggtggagga agaagaagaa    600
 gatgatgatg aagattctgg agctgaaata gaagatgacg atgaagaggg ttttgatgat    660
 gaagatgagt ttgatgatga acatgatgat gatcttgata ctgaggataa tgaattggaa    720
 gaattagaag agagagcaga agctagaaaa aaaactactg aaaaacagtc tgcagcggct    780
 ctttgtgttg gagttgggag tttcgctgat ccagatgacc tgccggggct ggcacacttt    840
 ttggagcaca tggtattcat gggtagtttg aaatatccag atgagaatgg atttgatgcc    900
 ttcctgaaga agcatggggg tagtgataat gcctcaactg attgtgaacg cactgtcttt    960
 cagtttgatg tccagaggaa gtacttcaag gaagctcttg atagatgggc gcagttcttc   1020
 atccacccac taatgatcag agatgcaatt gaccgtgaag ttgaagctgt tgatagtgaa   1080
 tatcaacttg caaggccttc tgatgcaaac agaaaggaaa tgttgtttgg aagccttgct   1140
 agacctggcc atcctatggg aaaatttttt tggggaaatg ctgagacgct caagcatgag   1200
 ccaagaaaga ataatattga tacacatgct agattgagaa gaattctgga tgcgttacta   1260
 ctcttctcat tacatgactt tagtggttca atccaaagaa acactggata ctttggaaaa   1320
 gtgggtgact gaaatcttct ctcagatacc aaacaatggg ttacccagac caaactttgg   1380
 ccatttaacg gatccatttg acacaccagc atttaacaaa ctttatagag ttgttccaat   1440
 cagaaaaatt catgctcctg accatccaca tggggcactt ccttcctcaa ccagcaacat   1500
 taccaggggt gaagccactt cattatatat cctggccggg ttggaccttg aaggcaaagg   1560
 cagcattctt tctttcctta ggaaaaaatg ctgggctctt gcactgtttg gtggaaatgg   1620
 tgagacagga tttgagcaaa attctactta ttcagtgttc agcatttcta ttacattgac   1680
 tgatgagggt tatgaacatt tttatgaggt tgcttacact gtctttcagg atttaaaaat   1740
 gctgcagaag ctaggcccag aaaaaagaat ttttgaagag attcggaaaa ttgaggataa   1800
 tgaatttcat taccaagaac agacagatcc agttgagtat gtgggaaaac atgtgtgaga   1860
 acatgcagct gtacccattg caggacattc tcactggaga tcagcttctt tttgaataca   1920
 agccagaagt cattggtgaa gccttgaatc agctagttcc tcaaaaagca aatcttgttt   1980
 tactgtctgg tgctaatgag ggaaaatgtg acctcaagga gaaatggttt gggaactcaa   2040
 tatagtatag gaagatattg aaaactcttg gggctgaact gtgggaatag taatttcgaa   2100
 ttaaatccag atctttcatc ttccagctgg aaaacaagta cataggccac gggactttac   2160
 gttggagggc tttcggtttg ccccggaaac agaataccca gttaaaattg tgaatactcc   2220
 acaaggctgc ctgtggtata agaaagacaa caaattcaaa atccccaaag catatatacg   2280
 tttccatcta atttcaccgt tgatacagaa atctgcagca aatgtggtcc tctttgatat   2340
 ctttgtcaat atccttacgg cataaccttg cgggaaccag cttatgaagc agatgtgggc   2400
 acagctggga gtattaaact ggtagctggg agaacatggt ttaattattc gagtgaaagg   2460
 atttaaccac aaactacctc tactgtttca gctcattatt gactacttag gctgagtttc   2520
 aattccacac cagctgtctt tacaatggat aactgagcag ttgaagaaga cctactttta   2580
 acatcctcat caagcccgag actttggcca aagatgtacg gcttttaatc ctgggaatat   2640
 gcccgttggt ctatgattga caagtaccag gctttgatgg acggcctttc ccttgagtct   2700
 ctgctgagct tcgtcaaaga attcaaatcc cagctctttg tggagggcct ggtacaaggg   2760
 aatgttcaca agcacagaat ctatgggatt tcctgaaata tgttgttgga caaactaaac   2820
 tttcaagcct ctgggagcag ggagatgcct gttgcagttt ccagggttgt agagctgccc   2880
 agtggcccac cattctaatg caaaagtgaa aagcttttga accagggtta tggccaactt   2940
 tggaagtcac tgtgtactac cagtcaggta cccaggagtc taagaggaat atacgcttat   3000
 ggagctgctt gtgatgcaca tgggaaggaa ccttgttttg acttccttcc gaaccaagca   3060
 gacccttggg tacctatgtc tacccctacc ctgtagggaa cacatcgggg gtattttagg   3120
 attttcttta cgctggggag accggcacac gcaattacaa ttctgaaagt tgttgaataa   3180
 gaaagataga agagtttctt tctagctttg aggggaaaaa ttgaggaccc tttattgaaa   3240
 agggcattca accaccccag gtcaccagct ctcgatcaag ctgaagggag tgtgaggata   3300
 cccccaccct tgggggaagg aaggtggaat aggaaactgg gaatgaaagt ggttaacacc   3360
 agacagtacc ctcctttgaa ccgcccttgc ccccacgaga ttgaagccac tgaaagtcat   3420
 tcctcaaaat ccagaccctg gtcaactggg ttcaaagccc atagagggcc ccggaagtaa   3480
 aatgcctcag cgttcatgtg agttgttgga tatgggaagt atgaactgga agaggatggt   3540
 cccccctctt agtgaggatt caaattcttc ttgtgaagtg atgcagctga cctacctgcc   3600
 aacctctcct cttgctgggc agattgtatt catccccatt tattgatgtt cagggctttt   3660
 cacaacaaca ctcaaccttc tcccctacca taaaatagtc aaataaaata aaactgcagt   3720
 ccacgttggc cctgaagcaa tgtgtatttt aaaatgtgtt tgtttgtatt ttatggagtt   3780
 agttatacta ctgccttagg gcttccattg aagttttgca ctggcatcat agcatttgat   3840
 ttacttttta tcctttgttg agactaataa acccagggtt actgtaggag ctggcaaagg   3900
 aaaattagca gaatgggcca agcgagacca gaaagcctgc agcagcactt tgagaagccc   3960
 tggcctgtgt cctctcagac tgagaatcta cttcttgaaa ggccttacgt aaccagtata   4020
 ttgaataact aactaaatgc taggtactaa tacctgtttt tttaatgtat ttttaaataa   4080
 aaaagatgat agatagatag atagatatag ttctgtattt cccttca                 4127



      <210> 478
      <211> 1423
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1423)
      <223> n = a,t,c or g


      <400> 478
 ccacgcgtnc gcccacgcgt tcgcccacgc gtccgaagcg ccttctccgc accagggatt     60
 ttcccaccca tttataagcc aagatgtcca gcaagcggtt tcaaagccaa gagcaccaga    120
 gaagcggcca tcttgcgtgt ccacatccaa tgtcttcgca atgttttatc cagtcccata    180
 tccaggagtt taaggaggct ttcaacatga ttggtccaga accgggatgg catcatttac    240
 caagaaggac ctgcacgaca tgctaagcct cgctggggaa gaaccccaca gacgaatacc    300
 tgggagggca tgattgagcg aggccccgtg ggcccattca acttcaccat gttccttcac    360
 catgtttggg gagaagctga acggcacgga accccgagga tgtgattcgc aacgcctttt    420
 gccttgcttt cgacggaggg aagccttcag gttttcatcc attgagggac caccttccgg    480
 ggagcttgct tcaccaccat gggtgaaccg ttttcacaga tgaggaagtg ggacgagatg    540
 taccgggagg gcacccattg gattaaggaa agggcaactt tcaactacgt gggagttcac    600
 ccgcatcctc aaacatgggc gccaaggata taagacgact agggccaccc ccagccccct    660
 tgacacccca gcccccgccc agtcacccct ttcccgcaca cacccgttcc ataccagctc    720
 ccctgcccca tgaacccctc gcttcagggg ttcccctttt tgaggggttt aggggttccc    780
 agtttcccag ttgggaagga aacagggcca gggagaagtt gcgttgcccg agcatgaggg    840
 cagatgttcc ccacagttga ccccaagagc cctggggctt aatagctctt ttgacccctc    900
 ccaaggaaaa gacccaccct tcttggggga cattgggctt ggaagggcag ggaccttaga    960
 aggcacccaa ggggaagggc ccctttttcc ggggcttgtt ttccccgagg ggagggaagg   1020
 ggaagggggg ttttgttgtt gccccccagg gaaggaagag ggccttgagt ccctgggatc   1080
 aagaacaccc ccttacgtgt atccccacac gaaatgcaag ctcaccaagg tcccctgtca   1140
 gtccccttcc ctacatccct gcacgcgcca ctgccgcaca cccacccaga gcacgccacc   1200
 cgccatggga gtgtgctcag gagttcgcgg gcaacgttgg acatttgtcc cagagggggg   1260
 cagaatctct caatagagaa actgagcact gaaaaaaaat gatacgctag aaacaaaaat   1320
 aataaaaaag cggccgcccc ttaataaagc cccccagggg ctcccacaga cagtcgctct   1380
 ctatagcaca ttgctcgctc ctattagcag ctaaataaaa tcg                     1423



      <210> 479
      <211> 1592
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1592)
      <223> n = a,t,c or g


      <400> 479
 tcctgcccca ccaccgctgc tcctcagcag gcgcctcacc agcctccaca ccccttgcgc     60
 ccgcagaaac gcgcctggcc ctgagctgtc accaccgaca ctctccaggc tccgttcacg    120
 aagcattctc atcaagtgtg tggaggtggg agatggggcc gtgggcaaga cctgccttct    180
 catcaactac accaccaacg cgtttcccgg agagtacatc cccaccgcgg ttgacaacta    240
 ttcatccaat gtgatggggg acagcaagcc agtgaacctg gggctgtggg acactggctg    300
 ggcaggagga ctacgaacgg tttcgggccg gtctcctatc cacagacgga cgtcttcctc    360
 atctgcttct ccctcgtcag cccagcctct tatgagaacg tccgcgccaa gtggttcccc    420
 agaagtgcgg taccactgcc ccagcacacc catcattctg gtggggcacc aagctggacc    480
 tgcgggacga caaggacacc atcgagaaac ttgaaggaga agaagctggg ctcccatcac    540
 cttaccctca ggcccttggc acttggccaa gaagattgac tcggttgaat tacctggagt    600
 gctcagttct caccctatga tgaggtcctg aaaacccgtg ttcgacgagg ccatccgggc    660
 cgtgctgtgc cctcagccca cgcggcagca gaagcgcgcc tgcagcctcc tctaggggtt    720
 gcaccccagc gctcccacct agatgggtct gatcctccag gatccccacc caaagcctga    780
 tggcaccccg gctggccatg ctgtcccctc cctgtggcgt ttcttagcag atggctgcag    840
 agcttcgttg atggtctttt ctgtactgga ggcctcctga ggccaggaac gtgcaaattt    900
 gcaggtgctg catcccaagc ccctcatgct cctgccttcc tgagggccca gaggggagcc    960
 ccaggaccca ttaaggccac cccccgtgtt cctgccggtc agtgccaaac tgcccgcatg   1020
 tggaagcatc tacccgttca ctcccagtcc caccccacgc ctgactcccc ttctggaaaa   1080
 ctgcaggccc agatggttgc tgcccacaac ttgtgtaccc ttcagggatg gggctcctta   1140
 ctcccctccc tgaggcccag ctgctcttaa tatcggatgg tcgctgcttg cccagagagt   1200
 tcctctaccc agcaaaaatg agtgtctcag aagtgtgctc ctctgggcct cagttctcct   1260
 cttttggaac aacataaaac aaatttaatt ttcctacgcc ctcttgggga tatctgctca   1320
 gccaatggaa aatttgggtt caaccagccc ctgccatttc ttaagacttt ctgctccact   1380
 cacaggatcc tggagctgca cttacctgtg cgagctctct caaaccctca aaccttgcca   1440
 gtcaggactt ttgctaattg caaatagaaa aaccaactca aacctgctta agcagaaaat   1500
 aaatttattg attcnnnnnn nnnnnngagg ggcggccgtt ttaaaggacc cctcgggggc   1560
 ccaaagttta cgcgggcttg caacgtaata ct                                 1592



      <210> 480
      <211> 847
      <212> DNA
      <213> Homo sapiens


      <400> 480
 agagagctgg tttcagactt cagaaggaca cgggcagcag acagtggtca gtcctttctt     60
 ggctctgctg acactcgagc ccacattccg tcacctgctc agaatcatgc aggtctccac    120
 tgctgccctt gctgtcctcc tctgcaccat ggctctctgc aaccaggtcc tctctgcatc    180
 acttgctgct gacacgccga ccgcctgctg cttcagctac acctcccggt cagattccac    240
 agaatttcat agtctgacta ctttgaggac ggaggcaggc cagtgcttcc aaggcccggg    300
 tgttcatctt cctaaccaag cgaagccggc aggtcctgtg cttgacccca gtgaggagtg    360
 gggtccaaga tatatttcag cgacctggga gctgagtgcc tgaaggggtc caagaagctt    420
 ccgaggcccc agcgaccctc gggtgggccc cagtggggga ggagcaggag ccttgaaccc    480
 ttgggaaaca tgcggtgtga ccctctacag ctaacctctt ccatgggact ggttattgcc    540
 aaacaggcca cactgtgggg actcttctta acttaaattt taattttatt tatacttatt    600
 tagtttttgt aaatttattt tcggttttca cagtgtgtct gggatttgtt ttgctctgag    660
 agttccccct gtcccctccc ccgttccctc aacagtgtgt ctggtgacaa ccgagtggct    720
 gtcatcggcc tgtgtaggca gtcatggcac caaagccacc agactgacaa atgtgtatca    780
 gatgcttttg ttcagggctg tgatcggcct ggggaaataa taaagcacgc tcttttaaaa    840
 ggtaaaa                                                              847



      <210> 481
      <211> 619
      <212> DNA
      <213> Homo sapiens


      <400> 481
 aattcggaac gaggcggaaa ggtgatacca tctgacagtc attttctcac gttggtcttc     60
 taaagtcacc tatttcttgt gtgtgcacat cacaccattt cctgtttctt tataacccga    120
 caagggtagg agtgcctgtt tcccctgctg ggcacaccag acaatcgtaa tcacaaaaca    180
 gacactgagc caggggccca aagggtgtga tcatgagagt taccgggaca gcagtaggca    240
 tgacagtcac caggaaggac aagggtgctc tgttgttagt ggccacacac caatttgaca    300
 aggagtgttg cgaaattttt atttatttat ttatttattt tgagatggag tttcactctt    360
 gtttgcccag gctggagtgc ggtggtacaa tctcggctca ctgcaacctc cacctcccag    420
 gttcaagcga ttctcctgcc tcagcctccc aagtacctgg gactacaggt gcgtgccacc    480
 acacccagct aaattttgtg tttttagtag agatggggtt tcaccatgtt ggccaggatg    540
 gtcttgaacc cctgacctca tgatctgcct gcctcggcct cccaaagtgc tgggattaca    600
 ggcatgagcc accacgccc                                                 619



      <210> 482
      <211> 2464
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2464)
      <223> n = a,t,c or g


      <400> 482
 cccacgcgtc cgcagagagc aagagagagg aactggggtt tgcgaacctt gtggctttgt     60
 ctgtttcctg tttcagcaag gctgctgtgc aaaaagaaag acggtaccaa gaagggacgt    120
 gttaatgggg cccagaccta tggattgaaa gcgtgtgctt tacccatctg ctgtcttgct    180
 ccatcttgag accatagcca agatctgtcc aggactggaa tgctttcccg agtggcttga    240
 gttggagcct gggactacga gcagccttat tgaggtacaa ttcatgtgct tgtgggtttg    300
 gatggcacaa tctgtgtctg ggctaaggaa agcagacttg gcaccaacat tatacctgac    360
 agatccatgc atctattgca ggaacttgta agccaagcgc aacaggtgct tggaggtcat    420
 catgatcagc ccagacccca ggccctcccc tggcttggcc cggggggctg agagctatga    480
 ggccaagtgt gagcgcaggc aagagatccg ggaaagccgc cgctgccgtc ccaatgtgac    540
 cacttgccgc caggtgggga agacgctgag gatccagcag agagagcagc tccagagagc    600
 tcgactgcag cagttcttca ggaggaggaa cctggagcta gaggagaagg gcaaagcgca    660
 gcatccccag gccagggagc aagggccctc caggcggcca ggacaggtga caggcaccag    720
 ctctgaagtc tttccagccc agcatcctcc tccctcaggc atctgcaggg atctgtctga    780
 ccacctctcc tcacaggctg ggggccttcc tccacaggac actcccatca agaagccacc    840
 caaacaccac cgtggtactc agacaaaggc agaaggacca acaattaaga acgatgccag    900
 tcagcaaacc aattacggag ttgcagttct ggataaggaa atcatccagc tttctgatta    960
 cctcaaagag gccctacaaa gggagctggt cctaaaacag aaaatggtga ttctccaaga   1020
 cctactgtcc actctgattc aggcctctga cagctcttgg aagggacagc ttaatgaaga   1080
 caaactgaag gggaaactga gatccttaga aaaccagcta tacacctgta cccagaaata   1140
 ctccccttgg ggaatgaaaa aagtactact ggagatggaa gaccagaaaa acagctatga   1200
 gcagaaggcc aaggagtcac tgcagaaagt gctggaggag aaaatgaatg cagagcagca   1260
 actacagagc acacagcgat ccctggccct ggcagagcag aagtgtgaag agtggaggag   1320
 ccagtatgag gctctgaagg aggactggag gacccttggg acccagcaca gggagctgga   1380
 gagccaactc cacgtgcttc agtccaaact gcagggagca gatagcaggg acttacagat   1440
 gaaccaggcc ctgcgatttt tggaaaatga gcaccagcaa ctgcaggcca agattgaatg   1500
 cctgcaaggg gacagagacc tgtgcagctt ggatacccag gacctacaag atcaactaaa   1560
 aaggtcagag gcagagaaac tcaccctggt gaccagagta cagcagttgc agggtttgct   1620
 tcaaaatcaa tccttacagc ttcaagaaca ggagaaactc ttaacaaaga aagatcaggc   1680
 tttgcccgtg tggagtccaa agtccttccc taacgaagtg gagcctgagg gtacagggaa   1740
 ggagaaagac tgggatctca gagaccagct gcaaaagaag actttgcagc tccaggccaa   1800
 ggaaaaggag tgcagagaac tgcattcaga attagacaac ctcagtgacg agtatctctc   1860
 ctgcctgcgt aagctgcagc actgtcgaga agagctgaac cagagccagc agctgcctcc   1920
 cagaaggcca atgtgggcaa aggcctccca gtgctaatgg tggtgattgc tccagcactg   1980
 gcagtgttcc tggccaataa aaacaacctg atgatttgaa taatttgtga caactgcctt   2040
 gggtgaaaat caaaagcaag caactcagcg aaaaactcaa aaggtttggg tacattacag   2100
 cttgggtttt ccaactgact taggatttct gactttttat taatttctta acctactgta   2160
 aataaacttc acctgaccag attgttgcaa tnnnnnnnnn nnnnnngggc ggccgtttta   2220
 aaggatcctt ggaggggccc aaagttaacg cgggctgtgc aacggaaaaa gttttttcct   2280
 tatagggggc cgaattaaaa ccatccttgg gaatttttgg aaaggaacct ttacttgtgg   2340
 ggggggacat aatgggccaa ccttccctac aaaatttaaa ggctctaggg aaaataaaaa   2400
 attttaaagg gaataagggg taaaactacc tgcatatgct ggctgctgga aagtttggtt   2460
 aacg                                                                2464



      <210> 483
      <211> 2086
      <212> DNA
      <213> Homo sapiens


      <400> 483
 gctgtttctg cccctgggtt aacattcaag atggtacatg ctgaagcctt ttctcgtcct     60
 ttgagtcgga atgaagttgt tggtttaatt ttccgtttga caatatttgg tgcagtgaca    120
 tactttacta tcaaatggat ggtagatgca attgatccaa ccagaaagca aaaagtagaa    180
 gctcagaaac aggcagaaaa actaatgaag caaattggag tgaaaaatgt gaagctctca    240
 gaatatgaaa tgagtattgc tgctcatctt gtagaccctc ttaatatgca tgttacttgg    300
 agtgatatta gcaggtttta ggtgatgtca ttacggatct gaaagacaca gtcatcttac    360
 ctatcaaaaa gaaacatttg tttgagaatt ccaggcttct gcagcctcca aaaggtgttc    420
 ttctctatgg gcctccaggc tgtggtaaaa cgttgattgc caaggccaca gccaaagaag    480
 caggctgtcg atttattaac cttcagcctt cgacactgac cgataagtgg tatggagaat    540
 ctcagaaatt ggctgctgct gtcttctccc ttgccataaa gctacaacca tccaataatc    600
 ttaatagatg aaatagactc ctttctacga accggttcaa ggttctgacc atgaagctac    660
 agccatgatg aaagctcagt ttatgagtct ctgggatgga ttggatactg atcacagctg    720
 ccaggtcata gtaatgggag ctaccaattc gtcctcagga ccttgactcg gctataatga    780
 gaagaatgcc tacaagattt catatcaacc agcctgcttt aaaacacgac gcgaagcaat    840
 cctgaaactc atcttgaaaa atgaaaatgt ggataggcat gtagacctgc tacgaagttg    900
 cccaggaaac tgaatgggtt ttcaggaagt gaccctaaaa gagatgtgtc gagatgctgc    960
 cctcctctgt gttagagaat atgttaattc tacatcagaa gaaagccatg acgaagatga   1020
 aattcggcct gttcaacagc aggacctgca tcgggcaatt gaaaagatga agaaatcaaa   1080
 ggatgcagca tttcagaatg ttttaacaca tgtttgttta gattaagagt aaagatcatt   1140
 tgtacagttc agtgatctag tttggtgtgt cctcttatca gttagtggaa atagaacgga   1200
 aagagtgctc tttaaacaat gagggagctc agtgtttatg gttttatact ctggaattct   1260
 aagttattgg aggatatagt tgttacatag ggtgggtatt accgttgggt ccaaaaatca   1320
 tgagggagga acagttgaat ccagcctgga acgtggggtg cttgtgtttg gaccttttcc   1380
 aggccatata ttgtacagcc ttatagaatc taagctggtc ttaaagtcat aaatgattca   1440
 ttgggtcatt aagtgagaaa cggggatgtg gttaggtgct ggttcctaga catgtggagt   1500
 atgcgtttgt gtgtgtgcgt gtatgtatgt gtatattaaa tgtatatatc cacaccattt   1560
 tatattgaca ttcctggtag gatatgtttg gaatatagga aacttttttt accccaacta   1620
 ctgaatccag ggagtaccaa ataatatata gtaaaactaa gatttaaggt tgtgtcaaaa   1680
 aggtacagtg attcagccat ttccatttgt catttgtttc aacctttttt aagttgagtg   1740
 tttttatttc tgcagttatt agttgggatc ctccacatct tggcatatat acatgggctc   1800
 aattattatg tttgtcagga taatcaaatg aaaatactag ttcagtgatc agcattgaat   1860
 ggttgttagg cagccatgtg ctcaacactg gatttcacct cttggagtat aaacttttta   1920
 aatttaaatt gggtttacat ggaaagtgga ttaaaaggcc tttcaaaaga atggggtttg   1980
 aaaaacctgc agtacccttt aatacatgta catttctttc cttttttcat ttaatgtaac   2040
 atgtctgttg taactatgtt tcttaaatat tattttaagg ttatgg                  2086



      <210> 484
      <211> 2527
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2527)
      <223> n = a,t,c or g


      <400> 484
 acaggtgacg ctcctcccgc ctgcctagca gagctccaag gcgcacatcc gcagtcagcc     60
 acctcgcgcg cgcctccagg agcaaggatg gagaggctga ctctgaccag gacaattggg    120
 ggccctctcc ttacagctac actcctagga aagaccacca tcaatgatta ccaggtgatc    180
 aggatgccct tctgtcatct gtctacctac agcctggttt gggtcatggc agcagtggtg    240
 ctgtgcacag cacaagttgc aagtggtgac ccaggatgaa agagagcagc tgtacacacc    300
 tgcttcctta aaatgctctc atgcaaaatg cccaggaagc cctcattgtg acatggcaga    360
 aaaagaaagc tgtaagccca gaaaacatgg tcaccttcag cgagaaccat ggggtggtga    420
 tccagcctgc ctataaggac aagataaaca ttacccagct tgggactcca aaactcaacc    480
 atcaccttct tggaatatca ccctggaagg atgaagggtt gttacatgtg tctctttcaa    540
 atacctttgg ttttggggaa gatcttcagg gaacggcctt gccttcaccg tctatgtaca    600
 gcccatagta tcccttcact acaaattctc tgaagaccac ctaaatatca cttgctctgc    660
 cactgcccgc ccagccccca tggtcttctg ggaaggtccc tcggtcaggg gattgaaaat    720
 agtacagtga ctctgtcttc acccaaatgg ggaccacgtc tgttaccagc atcctccata    780
 tcaaagaccc taagaatcat gtggcgaagg aggagatctg ccaggtgctg cacctggggt    840
 actgtgaccg actttaagca aaccgtcaac aaaggctatt ggttttcagt tccgctattg    900
 ctaagcattg tttcccgggt aattcttctc gtcctaatct tcaatcttac tgtactggga    960
 aacgtcaccg ggaatcaggg accgaggagc ccttaaatta agttcacaca ggcaccctgg   1020
 aaagttgatt tccctggtct acttgaattt gacaccaaga gaaaagccag gaggaaaagg   1080
 ggcccattcc tcccaaagga ccctgaaaga gcaaaaagag gtgggaccga aagcccttaa   1140
 ggatccccac gactttttac tgcccatcct gagcctacct cagtgtttga atccccaaga   1200
 ggaagtcagt ttacctctca ggtctgttgt aggacttgat tttgtaaagc aatgcccatg   1260
 ttatgtggtt gaaagggcac tggacttagt tagtatcagg agcactgatg ctcacagaac   1320
 tgacttgggc tcctactggt ggggacctct gttaagtcac ttttacctca tccaaaagta   1380
 taaaggaatt gggaccaaat taattttacc acatagctcc taaaaccttt aattttaaaa   1440
 ttgtaattcc caggaaaaaa aaaggggatt aagccaaagg gggggaagga tttgaaagag   1500
 agagagaaga aagaatacag agagcttacc ttttgccttt ctgttgatgt tacatctctt   1560
 cttcctatgt tcttagggtc tatgagtctg tttccccatc atttgggtat ctaagtccag   1620
 ttcctgctta ctgctttgcc aaataagctg ggccttgcta agaatccttg ggtttcactg   1680
 ctgttcttca tgtgccttct ttggaggttt actccaacac aaatagggac tgaatttatt   1740
 gtgaaggtaa cattgggcaa tcttaactta ttcattttaa cttattttta taggctagga   1800
 taaatattgt taggtcttag gacaataggc tcacattttt tgagaagcat gccctccctg   1860
 tcccatttgt cttataacat gacccagccc ctattttacc gtcattccta aattcagccc   1920
 tcatataatg aaaatacatt aatgaaaaac agatgtttag gagatttcct gtatagccag   1980
 tcagcccaat tccatatgcc tttgtcctct gactggcctt ctttttccca tgccgttaac   2040
 ttttccccaa tagccagagg aggcaaatat gagcatacaa tccctttgtt cctaaagata   2100
 ttgttcccag cctagtggaa tgatgttgaa tcctttaata accataatta gttgcttttt   2160
 cagtatcttc tgctttgtct gtgtctatcc gagtggccta ggaattaaag tgtaagttgt   2220
 tttcgtctgt taaattggga tatttatata tatatatata ggcaagattt tcatgtgtta   2280
 tttaattctg tattgtttct tatatttgta ggtaaaatat tgaaccaatt aaaagtgttg   2340
 actccaaata tttgggctta tgatattctc ttggggaaat gtgggaaatg aatgataatc   2400
 cttgtctttt cccattcata tgtaaaaacc ctcccctcct ctctatgctt tcccctccta   2460
 aaaaggatga gctggggctg gggcgcggtg ggntcaagnc tgccaatccc agttactttg   2520
 ggggggt                                                             2527



      <210> 485
      <211> 1262
      <212> DNA
      <213> Homo sapiens


      <400> 485
 tttcgtcgga aatgagcggg gcgtgggacg tgttgcgttt tcctagctgg cttacagggc     60
 ggcggcgggg tgtgtgtcct ctgttaagag tgctactcgc ccggggttga tctgtgcatg    120
 ccactcctgg gtcagacggt gaggtcggcg tctgcgagga cgcggcggtg gagtagaagg    180
 gcagccggag acaggcccgg cgccccttcc gaggctagac ggccccagct tcgcggggat    240
 catggcattg ctggtggacc gagtgcgggg ccactggcga atcgccgccg ggctcctgtt    300
 caacctgctg gtgtccatct gcattgtgtt cctcaacaaa tggatttatg tgtaccacgg    360
 cttccccaac atgagcctga ccctggtggc acttcgtggt tcacctgggc ttgggcttgt    420
 atatctggcc agaagctggg acatctttgc ccccaaaagt ctgccgccct ccaggctcct    480
 cctcctggcc ctcagcttct gtggctttgt ggccttcact aaccctttct ctgcagaaca    540
 acaccatagg cacctatcag ctggccaagg ccatgaccac gccggtgatc atagccatcc    600
 agaccttctg ctaccagaaa accttctcca ccagaatcca gctcacgctg attcctataa    660
 ctttaggtgt aatcctaaat tcttattacg atgtgaagtt taatttcctt ggaatggtgt    720
 ttgctgctct tggtgtttta gttacatccc tttatcaagt gtgggtagga gccaaacagc    780
 atgaattaca agtgaactca atgcagctgc tgtactacca ggctccgatg tcatctgcca    840
 tgttgctggt tgctgtgccc ttctttgagc cagtgtttgg agaaggagga atatttggtc    900
 cctggtcagt ttctgctttg cttatggtgc tgctatctgg agtaatagct ttcatggtga    960
 acttatcaat ttattggatc attgggaaca cttcacctgt cacctataac atgttcggac   1020
 acttcaagtt ctgcattact ttattcggag gatatgtttt atttaaggat ccactgtcca   1080
 ttaatcaggc ccttggcatt ttatgtacat tatttggcat tctcgcctat acccacttta   1140
 agctcagtga acaggaagga agtaggagta aactggcaca acgtccttaa ttgggttttt   1200
 gtggagaaaa gaatgttgtc ccaagaagat aaaaaatatt gttaagtgtg caagttatta   1260
 aa                                                                  1262



      <210> 486
      <211> 1129
      <212> DNA
      <213> Homo sapiens


      <400> 486
 gttcccaaaa gagaaagttt aatgactcat tttccccctt ttactccttt gagggtacag     60
 gataatgccc ttatctattt tcataataat tataatgatg atgataatga aaactaacgt    120
 ttgccaagtg ctaatactgt gtcaggatcc tcataacagc ccagggaggt agaaaccatc    180
 acaatgtcca ctgtccagat gagaaaatgg aggctaaggg tatttaaaga ggttgcccaa    240
 gaacaacaaa ccttttaaat ggcagactgg tgtgtataat ctacgcaggg ttcacatcta    300
 tggaacactt tattttaaat tcttttaata atattattat ttttcagctg agtctgggtc    360
 tcactctgtc gcccaggctg gaatgcagtg gcatgatcac agctcactgc ggcctccaac    420
 tcctgggctc aagtgattct cctgccccag cctcccgagt agctgggact acaggcttgc    480
 gccaccatgc ccggcttata gggcacttta gatggaaaca aatgactgga tctttaactc    540
 ctacctttct ctcctctctt cctgtaatgt tgttactgaa ggcaggaagg gagactcctt    600
 ggataaagag cagagcaaga gcctcaaagt ggtctttgtg agccaccctg gactactggt    660
 tcagtagagg gttgagtcaa gcaatatttg aggacgggat ataaacagta tttcttaaag    720
 ttgtcaccaa tttttccccc gatgaggcca ttccagaccc aaattagtca taacagagcc    780
 aggacaataa tcacatctcc tgattctgag cctgaatgct tcccacagga ctgcgtcgct    840
 caccattgct atgaggtcca ttgtggggga gagttgccac tgggattcca cctcaagggc    900
 tggggaccaa gcctccagga ttcctcttga gactcctcca ctatttcatt accatcccgc    960
 cacatctttt agtgctatgc cctggttccc tttggaatcc tctcaatccc aaagaaagcc   1020
 tcctaccacc tctaaggcat ccaaggtgtt aaaaagggcc ccaggacccg acagggcatc   1080
 cttctcattt taaaaaacaa ctgtggcctg gtgggtacgt gctcccggg               1129



      <210> 487
      <211> 1281
      <212> DNA
      <213> Homo sapiens


      <400> 487
 gccctgcagg ggcgccgaga tgtgggagct gctggccgcg gcgtgggcag ttcaggggct     60
 gggcggctga gggtgcaaat agctatgggc aacttggcct cggccataag gaagatgtgc    120
 tgttgcccca gcaactggaa tgacttctgt aaacccagga gtgtcaggag gatcacagga    180
 ggagggggcc actctgcagt tgtcacagat ggaggagacc tctttgtttg tggcctgaac    240
 aaagatgggc aactggggct tggtcacaca gaggatatcc catattttac ccccctccaa    300
 atccctcttt ggctgtccca tccaacaggt ggcctgtggc tgtgatttta cgattatgct    360
 cacagagaat gggcaagttc tatcatgtgg atccaactcc ttttggccag ttaggagttc    420
 ctcatggacc tcgaagatgt gtgggttccc caggccattg agctccataa agagaaggtt    480
 gtttgtattg ctgctggact taggcatgca gtagctgcta cagcgagtgg catcgtgttc    540
 cagtggggga ctggtttggc atcatgtgga cgacggttgt gccctgggca gactcttcca    600
 ttgtttttca cagcaaagga accaagcaga gtgacaggtc tagagaattc taaagcaatg    660
 tgtgttcttg ctggctcaga ccactcagct tcattaacag atgcaggaga ggtgtatgtt    720
 tggggaaagc aacaagcatg gggcaactgg ctaatgaggc tgctttcctt cctgtgcccc    780
 agaaaataga agcacattgt ttccagaatg aaaaggtcac tgccatctgg agtggatgga    840
 cacacctggt tgctcagaca ggtctcttgt ggctcagaag cataattttg gcaataattg    900
 gtggagtgtg ttactcttgg ggctgtgaat gagcatggca tgtgcggaga tggcactgaa    960
 gccaacgtct gggccccaaa gccggtgcag gctctgctgt caatcgtcag gactccttgt   1020
 gggctgtggg gctggccact tccttggccc tctgccagca tgccagctca ccctgcattg   1080
 gaccaggacc ccaaggacac ctacctttcc ccacatgcca tcgaggacac tgaatctcag   1140
 aaagccatgg accaaagaga gaaactggaa ggaaagacaa tcagaaactt caacccaaag   1200
 ccaatctgac tggtccagaa atgggggact gtgtatagag aatctttaat aaagttggct   1260
 tttcccacca aaaaaaaaaa a                                             1281



      <210> 488
      <211> 1281
      <212> DNA
      <213> Homo sapiens


      <400> 488
 gccctgcagg ggcgccgaga tgtgggagct gctggccgcg gcgtgggcag ttcaggggct     60
 gggcggctga gggtgcaaat agctatgggc aacttggcct cggccataag gaagatgtgc    120
 tgttgcccca gcaactggaa tgacttctgt aaacccagga gtgtcaggag gatcacagga    180
 ggagggggcc actctgcagt tgtcacagat ggaggagacc tctttgtttg tggcctgaac    240
 aaagatgggc aactggggct tggtcacaca gaggatatcc catattttac ccccctccaa    300
 atccctcttt ggctgtccca tccaacaggt ggcctgtggc tgtgatttta cgattatgct    360
 cacagagaat gggcaagttc tatcatgtgg atccaactcc ttttggccag ttaggagttc    420
 ctcatggacc tcgaagatgt gtgggttccc caggccattg agctccataa agagaaggtt    480
 gtttgtattg ctgctggact taggcatgca gtagctgcta cagcgagtgg catcgtgttc    540
 cagtggggga ctggtttggc atcatgtgga cgacggttgt gccctgggca gactcttcca    600
 ttgtttttca cagcaaagga accaagcaga gtgacaggtc tagagaattc taaagcaatg    660
 tgtgttcttg ctggctcaga ccactcagct tcattaacag atgcaggaga ggtgtatgtt    720
 tggggaaagc aacaagcatg gggcaactgg ctaatgaggc tgctttcctt cctgtgcccc    780
 agaaaataga agcacattgt ttccagaatg aaaaggtcac tgccatctgg agtggatgga    840
 cacacctggt tgctcagaca ggtctcttgt ggctcagaag cataattttg gcaataattg    900
 gtggagtgtg ttactcttgg ggctgtgaat gagcatggca tgtgcggaga tggcactgaa    960
 gccaacgtct gggccccaaa gccggtgcag gctctgctgt caatcgtcag gactccttgt   1020
 gggctgtggg gctggccact tccttggccc tctgccagca tgccagctca ccctgcattg   1080
 gaccaggacc ccaaggacac ctacctttcc ccacatgcca tcgaggacac tgaatctcag   1140
 aaagccatgg accaaagaga gaaactggaa ggaaagacaa tcagaaactt caacccaaag   1200
 ccaatctgac tggtccagaa atgggggact gtgtatagag aatctttaat aaagttggct   1260
 tttcccacca aaaaaaaaaa a                                             1281



      <210> 489
      <211> 1306
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1306)
      <223> n = a,t,c or g


      <400> 489
 cggacagtgc cccctagacc atagacccca cagagcataa cactgaagca caggatccca     60
 gatacggctc tcccaaactt tgttttgttt agtttaacat cgccaactca ctgttttgtc    120
 ttagaaacat gaaatcaaac agaatgagaa tataattttt tttggagttg gagcaaatct    180
 agataagggt cacaattgcc ccaagacttg cccaatttga gctcatgcta cacaattaaa    240
 tatattcctt aaatattgtg tgcttgcaac ttttgatttt gtaaatgggt tcccacagga    300
 caaaaatgag tcttaaacat aaaattaaac catatgaatg ttaggttttt taggttaatt    360
 tcagctgggt ggtannnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    420
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    480
 nnnnnnnnnn nnnnnnnaaa caaaaaagag ttaattccat tatatttatt tttacatacc    540
 cagagtttga ctaaaatata ccagacaatc tcctgtcccc aaatccatgt ccaagcaagg    600
 ggagccacgt tttctaagct cacagtttaa aggttaaaga gacactctga ggaaaactca    660
 gggaaagaag ctgatttgca tggacactag gcctgtcgtt gattccctca tttcaaaagt    720
 tgcatgtgcc atgggaggcg gagtctctga ggacatcctg gctgtgcctc ggcggctctg    780
 gactccagct ctacgcagag cgccttaaca ctgtactgga agaaatggga aatcgcattg    840
 aggacttaca gaaggaatgt caatgactta agtggtgcaa gctggcattg aaaattctat    900
 taaagaacaa atgctgaaga ccgtaactgc agcatgtctg tatttggaga tggggcctct    960
 tacagaagtc attaaggtta catccggtcc tgagggtggg gccctcatcc aacaggattc   1020
 gtctttctga gaagagacgc aaggggctcg cctgctcttc ccctccgtgc ctgcaccaga   1080
 gaaggaggcc atcggcaagc caaggagagc cctccccaga aatcacacgg accagcacct   1140
 tgatgtggga cttccagaaa ccagaactgt gaaaaggcaa gtttcctgtt gtgttaaacc   1200
 acccaatctg aagtattttg ttatggcagt cctgggcaga ctaatacaat atgcaacaca   1260
 tttacaataa atatacaata aacttaaaaa tgtggaatgt aaaaaa                  1306



      <210> 490
      <211> 392
      <212> DNA
      <213> Homo sapiens


      <400> 490
 cctgccctga cttctcatat cttgcctagg aactccaggc ttgtcttggg ctcccaaagg     60
 gatccccaac tgctccctgc accacaggtg gctcctgtgc ctgcgccggc tcctgcaagt    120
 gcaaagagtg caaatgtacc tcctgcaaga agtgctgctg ctcttgctgc cccgtgggct    180
 gtgccaagtg tgcccagggc tgtgtctgca aaggctcatc agagaagtgc cgctgctgtg    240
 cctgatgttg ggagagccct gctcccagac ataaatagag caaccagtac taacctggga    300
 tttttttttt taactaccct gaccggtttg ctacattctt ttttctattc aatatgtgaa    360
 aggacaataa aacacttttg gacttgaaaa aa                                  392



      <210> 491
      <211> 1874
      <212> DNA
      <213> Homo sapiens


      <400> 491
 acttgtaaac tacttctata ttagtcttta aaagattcgc ttatcttacg aatgattttg     60
 aataagcgtc cttgggaatg tttctagaga tgaatctccc tcccccagtc ctacgcttgg    120
 gtgaggaagt gtcgggtacc cgggcgacct gtcttcaggt gttctaggaa cgcggcccca    180
 tcccttgtca gcctctgtct ctgtgtggtg agaaggcgca ctggctcgtg cctctgcgaa    240
 actcgcgcac acagaaaaga ccaatcaagg acgggtcatt ctcgcccccc gcgcgccttt    300
 tgcgaccgcc cactcgacag gttgacaacc tagacagctc ccccggactt gccttacttt    360
 tccatctcct cccacccagc tataccctcc cactggcggc gcggatggca cgccggcgga    420
 gccagcgagt ctgcgcgagc ggtccgagca tgctcaatag cgcgcgcggc gccccggagc    480
 ttctccgcgg aaccgcgacc aacgcggagg tctcggcggc cgctgcggga gccacaggaa    540
 gtgaagagct tccgccggga gaccgcggct gcaggaacgg aggcggaagg ggccctgcgg    600
 cgacgacgtc gtcgacgtgg tgtggccgtg ggagctgagc acggagaaga ctccctctct    660
 cggaagccgg atcccgagcc gggcaaggat ggatcaccac cagccgggga ctgggcgcta    720
 ccaggtgctt cttaatgaag aggataactc agaatcatcg gctatagagc agccacctac    780
 ttcaaaccca gcaccgcaga ttgtgcaggc tgcgtcttca gcaccagcac ttgaaactga    840
 ctcttcccct ccaccatata gtaagtatta ctgtggaagt acctacaact ttcagataca    900
 gaagtttacg gtgaagtttt atcccgtgcc acctccctat aagcgttgct aacctctctt    960
 cctacatacg atgaagctga gaaggctaaa gctggctgca atggcagctg cagcagcaga   1020
 aacatctcca agaattcagg aggaagagtg tccaccacga gatgaccttc tgtgatgcag   1080
 accacctcaa agtggggaat gatggcattc tcatgctggc atttttcatg gcatttattt   1140
 tcaactggct tggattttgt ttatccttct gtatacacca ataccatagc tggaaggtat   1200
 ggtgctatct gcggatttgg cctttccttg atcaaatggg atccttattg tcaggttttc   1260
 tgattatttt actgggatat ttcaatggga cagtattggc tttgggtggg atatttcctt   1320
 gttacttggg cctggcttcc ttttctttca ggagggattt gttaattatc taaaagtcag   1380
 aaaccatgtc tgaaagtatg gcagctgctc atagaacaag gtatttcttc ttattgtaga   1440
 gactgcatca acccgacatt cctttcttat accaatgtga aatttccaga tcatctgtaa   1500
 acctacaact ttaatagaag actactaata acagaagaca aattagtgaa gaaaagacag   1560
 agttctcgga aattggaatg ggcaggggtg ggtttttcgc tttacagagc acattctctg   1620
 tctcattctt taagtatctc atatcttcat ttgtttttgc acatatggca tatggggccc   1680
 atttaaggat atttggcata tacttgatag aaaccataaa gttgtagcag ttaagtccag   1740
 tcacatttgg ttaatcagtg tttgatataa ttgaaagagt tgagtggata aacagtcttc   1800
 cagcttgtaa atgccattga cttctgacct gacatttagt ataataaaaa tgaaattctt   1860
 aaccatgtca aaaa                                                     1874



      <210> 492
      <211> 1943
      <212> DNA
      <213> Homo sapiens


      <400> 492
 ttgggtattt gcaagtctag agctttaggt gttactggtt ttaaaggtgt caggggcagc     60
 tggggctgcg taaggtaagg tggcagagga aaggagtagg tgaatggaac ttactcacat    120
 cctaagccca caggttgaga acttctgttc agctccctca ggggtttgcg aggctgcctt    180
 tgcttttcta gccccctaaa cgggcccccc ttctctctac aggtgtttcc cattaaacac    240
 taccaggaca aaatcaggcc ttacatccag ctgccatcgc acagcaacat tactggcatt    300
 gtggaagtga tccttgggga aaccaaggcc tatgtcttct ttgagaagga ctttggggac    360
 atgcactcct atgtgcgaag ccggaagagg ctgcgggaag aggaagccgc ccggctcttc    420
 aagcagattg tctccgccgt cgcccactgc caccagtcag ccatcgtgct gggggacctg    480
 aagcttagga agttcgtctt ctccacggag gagagaaccc agcttagact agaaagtcta    540
 gaagacacac acataatgaa gggggaagat gatgctttgt cagacaaaca tggctgccca    600
 gcctacgtga gccctggaga tcctcaacac cactgggacc tactccggaa aggctgcgga    660
 cgtttggact ggggggggtg atgctctaca cccttctggt tgggacgata ccccttccat    720
 gactcagacc ccagtgccct tttctccaaa attcggcgtg gacagttctg cattcctgag    780
 cacatttccc ccaaagccag gtgcctcatt cgcagcctct tgagacggga gccctccgag    840
 agactcactg cccccgagat cctactgcac ccctggtttg agtccgtctt ggaacccggg    900
 tacatcgact tcagaaatag gaacttcaga ccagattgtt ccagagtacc agggaggaca    960
 gtgacattag ttccttcttc ttgcttaatc cccaaaacct tcaggaaacc tcataattct   1020
 taacacctgg catttccatt tctaaagatg gacaggccct ttggcgtggt accaaccaga   1080
 taatgactgc atcaggatga aagctgctga actcggcatg gcgcctcctc ttctctgttg   1140
 ggatgagtga ctttattgat ttgagcagca tatgctgtga ttggctgccc tgcaaatttg   1200
 tttcccttaa ggaaccctca ccaactaatc tctgctggat ttgggagttc cgcatctttt   1260
 gtggagggca gagtatggac atcttacacc cggtggtcaa gtgtgtaata aacttgagca   1320
 ttcgaatggg agaaaaagca aatcgcacaa tgacatattt tgagtaataa ccgtattttt   1380
 cacagggtga caaattgggc caataaatct gccatctttg aactcatctt tggtggctag   1440
 actgctacgg cagcttctct gatgggaaag ttcctttttt ggcttaacac tcaccctttc   1500
 ttcacactca catttaccaa tgactctgct ccgtttttgg agcagactgt tttaagttgc   1560
 tcaggagcct gatggaacca tgaaccgaga ctcttctctg tttcctgcca agacctcatc   1620
 tgcactaatg ccttctccct gaccttgaca cttccccctt tagctataaa agcacttacc   1680
 agccgaacgt ggaacagtat cacaaaagat tccatctccc aacgatttca gaactctgag   1740
 ctcagagaga ctccagattt taaaaaataa tttgagtgct tggaaactat tagcttttta   1800
 agttccttcc aaatatgtta gtacctaccc tttacttttt ccccaagacc atctcagggt   1860
 ggagcattct gtctaagaga agaaagataa ggaggctccc acccacctct cccaagagca   1920
 gacattaaac atctttgtgc ttt                                           1943



      <210> 493
      <211> 541
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(541)
      <223> n = a,t,c or g


      <400> 493
 cagatcccga agcagcgctg tgagcgtaag tgcgggcaga gcactgcgcc gtttgggaac     60
 gcaactttga ggagacagtg cggtggactt cagtgaagtt ccttatgact ttcccctgaa    120
 aattgccttc ccttatccat gggggccaaa tgaaagtaaa aggctcctaa tacaacccta    180
 taaggactgc cnaagtatgg ccagggggca agtcggactt gggattggag agaaacagga    240
 actgagcatt ctcctgggtg tgcagcctgc agcctgcaga tgtgaaggaa agttgttgag    300
 aagggtgtac agactcttgt gattgggccg agggatgagt gaggccttga aggtgccttc    360
 atcaactgtg gagtacctca aggaaacatg gcattgatgt gcagggtcct ccagacagag    420
 caggcagtga aggagtataa tgccttggtt gcccaagggg tcagggtggg aggtgtcttc    480
 cattccacct gctgatggta gccttaagag gagaataaat cactaagtgc ctaaaaaaaa    540
 a                                                                    541



      <210> 494
      <211> 5607
      <212> DNA
      <213> Homo sapiens


      <400> 494
 ggcttcctca ctatagggct cgagcggccg cccgggcagg ttaaaaagcc aacattcctc     60
 tgcttcatag gtgaacagca aagatttctc tacccctcaa atgcagctag aattcagcgg    120
 ccgctgaatt ctttcctgct cactcagtag tcaggtgggc ttgacgtctg tgaccagtat    180
 tcaagagagg atcatgtcta cacctggagg agaggaagct attgaacgtt taaaggaatc    240
 agagaagatc attgttgagt tgaatgaaac ttgggaagag aagcttcgta aaacagaggc    300
 catcataaat ggagagagag gctttgttgg ctgagatggg agttgccatt cgggaagatg    360
 gaggaaccct aggggttttc tcacctaaaa agaccccaca tcttgttaac ctcaatgaag    420
 acccactaat gtctgagtgc ctactttatt acatcaaaga tggaattaca agggttggcc    480
 aagcagatgc tgagcggcgc caggacatag tgctgagcgg ggctcacatt aaagaagagc    540
 attgtatctt ccggagtgag agaagcaaca gcggggaagt tatcgtgacc ttagagccct    600
 gtgagcgctc agaaacctac gtaaatggca agagggtgtc ccagcctgtt cagctgcgct    660
 caggaaaccg tatcatcatg ggtaaaaacc atgttttccg ctttaaccac ccggaacaag    720
 cacgagctga gcgagagaag actccttctg ctgagacccc ctctgagcct gtggactgga    780
 catttgccca gagggagctt ctggaaaaac aaggaattga tatgaaacaa gagatggaga    840
 aaaggctaca ggaaatggag atcttataca aaaaggagaa ggaagaagca gatcttcttt    900
 tggagcagca gagactggac tatgagagta aattgcaggc cttgcagaag caggttgaaa    960
 cccgatctct ggctgcagaa acaactgaag aggaggaaga agaggaagaa gttccttgga   1020
 cacagcatga atttgagttg gcccaatggg ccttccggaa atggaagtct catcagttta   1080
 cttcattacg ggacttactc tggggcaatg ccgtgtacct aaaggaggcc aatgccatca   1140
 gtgtggaact gaaaaagaag gtgcagtttc agtttgttct gctgactgac acactgtact   1200
 cccctttgcc tcctgaatta cttcccactg agatggaaaa aactcatgag gacaggcctt   1260
 tccctcgcac agtggtagca gtagaagtcc aggatttgaa gaatggagca acacactatt   1320
 ggtctttgga gaaactcaag cagaggctgg atttgatgcg agagatgtat gatagggcag   1380
 gggagatggc ctccagtgcc caagacgaaa gcgaaaccac tgtgactggc agcgatccct   1440
 tctatgatcg gttccactgg ttcaaacttg tggggagctc ccccattttc cacggcctgt   1500
 gtgaacaagc gccttgccga ccgcacaccc tcccccactt ttttccacgg ccgattccga   1560
 catcactgag ctggctgccg accagcaaga tgagatggag gtttttgatg atgaggcatt   1620
 cgtggatgac gccggctctg acgcagggac ggaggaggga tcagatctct tcagtgacgg   1680
 gcatgacccg ttttacgacc gatccccttg gttcatttta gtgggaaggg catttgttta   1740
 cctgagcaat ctgctgtatc ccgtgcccct gatccacagg gtggccatcg tcagtgagaa   1800
 aggtgaagtg cggggatttc tgcgtgtggc tgtacaggcc atcgcagcgg atgaagaagc   1860
 tcctgattat ggctctggaa ttcgacagtc aggaacagct aaaatatctt ttgataatga   1920
 atactttaat cagagtgact tttcgtctgt tgcaatgact cgttctggtc tgtccttgga   1980
 ggagttgagg attgtggaag gacagggtca gagttctgag ggtcatcact cctccagaag   2040
 aaatcagtcg aattaatgac ttggatttga agtcaagcac ttttgctgga tggtaagatg   2100
 gtaatggaag ggttttctga agagattggc aaccacctga aactgggcag tgccttcact   2160
 ttccgagtaa cagtgttgca ggccagtgga atcctcccag agtatgcaga tatcttctgt   2220
 cagttcaact ttttgcatcg ccatgatgaa gcattctcca cggagcccct caaaaacaat   2280
 ggcagaggaa gtcccctggc cttttatcat gtgcagaata ttgcagtgga gatcactgaa   2340
 tcatttgtgg attacatcaa aaccaagcct attgtatttg aagtctttgg gcattatcag   2400
 cagcacccac ttcatctgca aggacaggag cttaacagtc cgcctcagcc gtgccgccga   2460
 ttcttccctc cacccatgcc actgtccaag ccagttccag ccaccaagtt aaacacgatg   2520
 agcaaaacca gccttggcca gagcatgagc aagtatgacc tcctggtttg gtttgagatc   2580
 agtgaactgg agcctacagg agagtatatc ccagctgtgg ttgaccacac agcaggcttg   2640
 ccttgccagg ggacattttt gcttcatcag ggcatccagc gaaggatcac agtgaccatt   2700
 atccatgaga aggggagcga gctccattgg aaagatgttc gtgaactggt ggtaggtcgt   2760
 attcggaata agcctgaggt ggatgaagct gcagttgatg ccatcctctc cctaaatatt   2820
 atttctgcca agtacctgaa gtcttcccac aactctagca ggaccttcta ccgctttgag   2880
 gctgtgtggg atagctctct gcataactcc cttcttctga accgagtgac accctatgga   2940
 gaaaagatct acatgacctt gtcggcctac ctagagctgg atcattgcat ccagccggct   3000
 gtcatcacca aggatgtgtg catggtcttc tactcccgag atgccaagat ctcaccacca   3060
 cgctctctgc gtagcctctt tggcagcggc tactcaaagt caccagattc gaatcgagtc   3120
 actggcattt acgaactcag cttatgcaaa atgtcagaca caggtagtcc aggtatgcag   3180
 agaaggagaa gaaaaatctt agatacgtca gtggcatatg tgcggggaga agagaactta   3240
 gcaggctggc ggccccgtgg agacagcctc atccttgagc accagtggga gctggagaag   3300
 ctggagctcc tacatgaggt ggaaaaaacc cgccactttt tgctgctgcg tgagagactt   3360
 ggtgacagca tccccaaatc cctgagcgac tcgttatccc ccagcctcag cagtgggacc   3420
 ctcagcacct ccaccagtat ctcctctcag atctcaacca ctacctttga aagcgccatc   3480
 acacctagcg agagcagtgg ctatgattca ggagacatcg aaagcctggt ggaccgagag   3540
 aaagagctgg ctaccaagtg cctgcaactt ctcacccaca ctttcaacag agaattcagc   3600
 caggtgcacg gcagcgtcag tgactgtaag ttgtctgata tctctccaat tggacgggat   3660
 ccctctgagt ccagtttcag cagtgccacc ctcactccct cctccacctg tccctctctg   3720
 gtagactcta ggagcaactc tctggatcag aagaccccag aagccaattc ccgggcctct   3780
 agtccctgcc cagaatttga acagtttcag attgtcccag ctgtggaaac accatatttg   3840
 gcccgagcag gaaaaaacga atttctcaat cttgttccag atattgaaga aattagacca   3900
 agctcagtgg tctctaagaa aggatacctt catttcaagg agcctcttta cagtaactgg   3960
 gctaaacatt ttgttgtcgt ccgtcggcct tatgtcttca tctataacag tgacaaagac   4020
 cctgtggagc gtggaatcat taacctgtcc acagcacagg tggagtacag tgaggaccag   4080
 caggccatgg tgaagacacc aaacaccttt gctgtctgca caaagcaccg tggggtcctt   4140
 ttgcaggccc tcaatgacaa agacatgaac gactggttgt atgccttcaa cccacttcta   4200
 gctggcacaa tacggtcaaa gctttcccgc agatgcccga gccagtcgaa atactaagtg   4260
 actctgccga gtgccctcac tcgccttcga gagataaaga aagcgttacc tctcatttct   4320
 ctttgtgatt cttgacggtg actcttgtat gtaatcctgt ggcttaacta cttctccctc   4380
 cttgtccagc acttttctag ctctcccgtt ccccatctcc attgctctgt actcttttct   4440
 tttttcttgt gctgagaatc tcgttagtag catgtggcct aacaaaagga aaaaatgttt   4500
 ttaaacacac acacacacac acacacacac acacacatac acagacaaaa acacaaaaac   4560
 tctgagggga tctggtgaat ctccaaatta ttgtgggtgt actttggctt ccttttgtat   4620
 gataggtccc catcatgacc acctctgatg tctgtgctgc tgtcaccagg cacctttgtt   4680
 tttcaagaca acatactttt tttttctttt ctctgtttgt gatatcactt taatttttct   4740
 tgggtggctt agagactaag ggaggagaca tctggccttt ttagaacctg agaggaaaaa   4800
 aagagtcttt ttttcccctc tgtctctttt tgccatggct aatccctgca tttccattca   4860
 gggaaaaggt ggtagtgagc atagaactgc aacagttata ttctgagtca aagttggggc   4920
 tttttacggc ataattatgg aatttttatt tactggtaga gaggagacga gaggcttttt   4980
 cagtgggcct gggacagtgg ctgctcttga ctttgtgtga agggaaatgc caaggatgct   5040
 tctggtggac ttcaggggac cccagggttt ggccgtgggc cgtgatggca gcaggcggtg   5100
 ggatgcttgt agctcctcac agcaggattc ctgcccactg ttttttctct gttgggaggg   5160
 aagctctttt ctaggagtgt ctcagttctg cttttggcat tagtgatggt ggtggtacag   5220
 ttggaattag tgccatgtca tacacaaatg ttccacaagg cgggagtgtt tcactttctg   5280
 gtgataaact tgatggtcat tgttatgatt aagataatgc cgggcaggcc gggcacagtg   5340
 gctcacgcct gtaatccaag cacttgggga ggccgaggcg ggcagatcac gagatcagga   5400
 gttcaagacc agcctggcca atgtgatgaa accccgtctc tactaaaaat acaaaattag   5460
 tcgggtatgg tggcacatgc ctgtaattcc agctgcttgg gagcctgagg caggagaact   5520
 gcttgaaccc aggaggcaga ggttgcagtg agccaagatc gcgctattgc actccagcct   5580
 gggtgacaga gcaagactct gcctcag                                       5607



      <210> 495
      <211> 1280
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1280)
      <223> n = a,t,c or g


      <400> 495
 ctcgtcgctg cagccggcgg ctagcgggcg tccgcgccat ggagcgctac gcgggcgcct     60
 tggaggaggt ggcggacggt gcccggcagc aggagcgaca ctaccagctg ctgtcggcgt    120
 tacagagcct ggtgaaggag ttgcccagct cattccagca gcgcttgtcc tacaccacgc    180
 tgagcgacct ggccctggcg cttctcgacg gcaccgtgtt cgaaatcgtg caggggctac    240
 tggaggatcc agcacctcac cgaaaagagc ctgtacaacc agcgcctggc gcctacagaa    300
 cgagcatcga gtgctcaggc aggcgctgcg gcagaagcac caggaagccc agcaggcctg    360
 ccggccccat aacctgcctg tgcttcaggc ggctcagcag ccgagaacta gaaggccgtg    420
 gaacacncgg atccgtgagg agcaagcggg cgattggacc agaagatcat cctggagctg    480
 gaccggaagg tgggctgacc agcagagcac actggagaag gcggggggtg ggctgggctc    540
 ttacgtgacc accaacccac aggagctgat gctgcatgat gaaccatgct ggaacatcat    600
 ccggaaagct gcagcagatt gggctgccgg ggcagggata tgcagccctg ggactgggga    660
 ggtcccctgg cagttgcctt ctgcccagtg tgaccagaaa ggcagccctg tcccaccata    720
 gccacaggca acagaagttt gggcaaagtt catttttttg accttttggc cacttgcctt    780
 ccctagctgc ntccgcaggg ggttcccccc tgctgcaggg agagacccag gtggacccca    840
 agcttgcctg tcaccctttc aatcttggga cttgctgtca aacccttagg atagtctcat    900
 aaaggggagg ctgggccagc ctgctgctgt ctgcttcagg acccaggcag agagtgaggc    960
 tgggggttct cacaccttac tccaccgggc acattcccaa cctgctactg gggcccactc   1020
 aagtgcttgt tctggtctca gccgctccct tggcagctgc agcccccatg cagaagaggc   1080
 tcccaggccc aagctctgtg tgacccaaga gaaatacaag atgcctcagt gtggcccaaa   1140
 aagaaaaaac taaaggactt ttattgaagg ggcccagcgt ttattccctt taaggggggc   1200
 atttttactg tccaccctgg ccctgttttt aacggacagg agtgggaaaa aaccccccat   1260
 ctgtggacaa ggggtgagtc                                               1280



      <210> 496
      <211> 2324
      <212> DNA
      <213> Homo sapiens


      <400> 496
 aactgatcgt cccacccagt tcttgaacag ccccaatgct gttcatgaag gtggaagaag     60
 tggctgcccc ggctgcatgc tcttgtcgta ggacctggct tgggtagaga tgatcgtcca    120
 cccagttctt gacagcccca atgctgttca tgaggtggag aagtggctgc cccggctgca    180
 tgctcttgtc gtaggaactg gcttgggtag agatgatgcg cttctcagaa atgtccaggg    240
 catttttgaa agtgtcaaag gccagggaca tccctgtttg tcatcgacgc ggatggcctg    300
 tggctggtcg ctcagcagcc ggccctcatc catggctacc ggaaggctgt gctcactccc    360
 aaccacgtgg aagttcagca gacttgtatg acgctgtgct tcagaggccc tatgggacag    420
 cgatgacagc caatggatct gttgctaaag acttcaagcc aaagccctgg ggcaacgtga    480
 cggtggtcca gaaagggaga gcgcgacatc ctctccatcg gccagcaggt gcatgtgtgc    540
 agccaggaag gcagcaagcc gcaggtgctg gagggcaagg ggacctcctg tcgggctccc    600
 tgggcgtcct ggtacactgg gcgctccttg ctggaccaca gaaaacaaat gggaccagcc    660
 ctctcctggt ggccgcgttt ggcgccatgc tctctcacca ggcagtgcaa ccaccaagcc    720
 ttccagaagc acggtcgctc caccaccacc tccgacatga tcgccgaggt gggggccgcc    780
 ttcagcaagc tctttgaaac ctagagcccg cgcagaccag aagtaaacag gcaccttgga    840
 cggaggagag cgtgtgtgtg atgggaaaat ccggacccac gcgtgtgctg aaggcgtacg    900
 gtgcttgcca gattttcaac ttgagcataa attggttgcc attgagaatt taagaatctg    960
 gaatattgca gggtcttggg taaacttaat gcatgggtgg agatgttagt ggggacacta   1020
 aacaaagcat tcctgagagt gccttagctc cttggtaagt aacttgggaa gacagaaatg   1080
 aagaaaatca cattgagaat gaagaattct ttagcagctc aacagagttt ctcggcctgc   1140
 tcccagatcg gcgaagtttc tacttgttac tctctctgcc ggcgcccttc gttcctcctc   1200
 tgcttcactt ccctagtctt tcctccggca ggggagctgg gcaggggtcc accgggtgtc   1260
 tccctcgagt ccccgactcg cactcgactg ggtccatcag aggggctggc tttcgtttct   1320
 tccagcttca tcttctttta aatgtggtga ctagcttggt ggtatctggg ctgctggtgt   1380
 ttgggcttat ttgacatact ccaggggtaa tcaatgatga ctttgtttgg gaaacccttt   1440
 ttggaggcac catggggaac agaaggaaac atgagtgacg ctgacccttg agtgtgtggg   1500
 tggggagctc tgagacgcct cctgtcccac gctctccggt gtccgtgtct acacaggggt   1560
 ccccaatgat acccaccggc cccagcaggg caagaccgga ccggggacgg gcacggtgaa   1620
 gggcttgcag cttggggtct gacgttggcc ccctaattgc tgtctcagga gaaggctctg   1680
 gaggacttta aggcatgcct gggcctggtt gcagtgatgg cgctaagaac tacccgggga   1740
 aagacagtat cgtggtcacg tatgcttaag gaagcagcac agccagtgtc cttaagggat   1800
 gttcgcgtcc agtaaagaca ctggtaactg cggtttcagc caaacaactc ttcatggcag   1860
 ttgtcgacct cgggttagct tctgttgtct ttgtggatgg ttttcctgga gcggcctgac   1920
 gttgacgtgt tctctggtcc caagttctaa ccggggcatg gtacggtttc gtgcctgacg   1980
 cagtgcatta gggtgttctc ttatactttc agtagcgtct ttccacagca agggccaaac   2040
 cctcctggtt cccttcaaga gtctttttgg cctgatgatg actcttgaag tgataccctg   2100
 tgatgcagac atgcccccag atgggattct actttcttta aaactaaggg actttccaag   2160
 attaaaaaaa agatttgtca ctactaattt gacgcctaac ttcagaagct tcactgtcta   2220
 catgtgaact tttccagaaa aactgtgcca tggacatttt tcctctgggg aattaacatc   2280
 taaattctgg taactattaa aagacagatc tggttaattt aaaa                    2324



      <210> 497
      <211> 1793
      <212> DNA
      <213> Homo sapiens


      <400> 497
 tttcgtgcag gactcttggt ggggtagcga gggggacggt cccacgactg ctccgaaggg     60
 ccgggactcc cagtgggggc gggacccccg gagtgcccgc ctgcggactc ccaagcctgg    120
 agcctgggga gagggtgggc acctccgttc ccgcacaccc gtccatggtg tgtgcgccga    180
 gcgtccagga gccacggcgg tgtcttcctt gcgcgtcttt tacacgtgtg ggggtaggct    240
 gctcctcggg gctgagccgt ggccagggtt atggagaggc ccgcctctcc ccagatggcg    300
 tcgtcgagcc ctgactcccc atgttcctgc gactgctttg tctccgtgcc cccggccttc    360
 agccatcccg gctgtgatct ttgctcatga actcgggacc gaccccggga cgaggtgcag    420
 gaggtggtgt ttgtccccgc aggcactcac actcctgggg agccggctcc agttgcacct    480
 tacattgaag ttggaacagg tgtcgaagac gcaccgctgt gattctgagc cgtccttctt    540
 ggctatgggg ggctgagatt gggccgccaa cgaagcatgg tgtctgcatt ggcaaccgag    600
 gctgtgtgga ccaaggaacc agttggggag ggggaaaccc tggtgggcat ggaccttact    660
 cagctggctt tggaacggag cagctctgcc caagaagccc tggatgggaa caccaagggt    720
 tacggaacca cttattgggc aggggggcaa ctgcctggag gatgctgcgc cattctccta    780
 ccatagcacc ttcctgcttg gctgaccgca ctgaggcgtg ggtgctggag acagctggga    840
 ggctctgggc tgcacagagg atccaagagg ggggcccgca ccatctccaa ccagctgagc    900
 attggcacgg acatctcggc ccaacacccg gagctgcgga ctcatgccca ggccaagggc    960
 tggtgggaat gggcagggtg cctttgactt tgctcagatc ttctccctga cccagcagcc   1020
 tggtgcgcat ggaggctgcc aaggcccgct tccaggcagg gcgggagctg ctgcggcaac   1080
 ggcaagcttc cccctctact ccttggcagg gggcatcacg gcagaggtga tgatgggcat   1140
 cctcagagac aaggagagtg gtatctgtat ggactcggga ggctttcgca ccacggccag   1200
 catggtgtct gtcctgcccc atgaatccaa cgcagccctg cgtgcaactt tcttaccgcc   1260
 acgccagacc catccaggtc tgtgttcaaa cctttcatct tcgggatggg ggtggcccag   1320
 ggccccaggg tgctgtcccc cacttttgga gcacaagacc ctgttcggac cctgccccga   1380
 ttccagactt caggtagatc gttcggcata ccctcttacc gtgggacacc agggcagccc   1440
 tggggctgat ggagagagat caggattggg ggcagccagc tccagcagaa acggcaggat   1500
 ctggagcagg aaggcctcga ggccacacaa ggggctgctg gccggcgagt gggccccacc   1560
 cctttgggag ctgggcagcc tcttccaggc cttcgtgaag agggagagcc aggcttatgc   1620
 gtaagcttca tagcttctgc tggcctgggg gggtggaccc aggacccctg gggcctgggt   1680
 gccctgagtg gtggtaaagt ggagcaatcc cttcacgctc cttggccatg ttctgagcgg   1740
 ccagcttggc ctttgcctta ataaatgtgc tttattttca aaaaaaaaaa aaa          1793



      <210> 498
      <211> 2607
      <212> DNA
      <213> Homo sapiens


      <400> 498
 acgaggacag gaggctcaag ggggcggagg cggcgttgcc gggctctccg gaaggagacg     60
 tggcggcggt tgggccggtg atacccgggc gctttatagt cccgccgcct cctcctccac    120
 ctcctcctcc tcctcctctc ctcctggagc aaaggaggtt gtggcggtgg ctggagaaag    180
 cggcggcgga ggatggagga aggaggcggc ggcgtacgga gtctggtccc gggcgggccg    240
 gtgttactgg tcctctgcgg cctcctggag gcgtccggcg gcggccgagc ccttcctcaa    300
 ctcagcgatg acatcccttt ccgagtcaat gggcccgggc acggagttct ctctgcccac    360
 aactggagtt ttatataaag aagataatta tgtcatcatg acaactgcac ataaagaaaa    420
 atataaatgc atacttcccc ttgtggacaa ggggggatga ggaagaagaa taggattata    480
 aaggccctaa tccaagagag cttttggagc cactatttat acaaagcagt tgttcctaca    540
 gaattgagtc ttattggact taacaaatat ggttttggaa aaaccaatcc ggcggtccct    600
 atgaaaaaaa agaactgtca gaaaataaat attcaccgag tactaccttg ggaatatgtt    660
 ggccaagaac cttctatttg aaaaagaacg agaagcagaa gaaaaggaaa aatcaaatgg    720
 agattcccac tattggttgg ggtggccaaa tgacaccata ctatcctgtg ggaatgggga    780
 aatggtacac cttggtagtt tgaaacagaa cccggcccag atcaagtacc tgtgatgtac    840
 atatgtcatc ctgaatctaa ggcatgaaat tctttccagt agctgaaggt tacaacttgt    900
 gaatatggaa gttgtcattt tgacaccact ccttgtgcag ttcatcctaa aatataggtt    960
 cagaagcatc tcccggtgga atggacatat tttggtcaaa tcactgccag gattctccat   1020
 ttaagccccc tcaccctgag gcagctggag cagcaggaag aaatactaag ggtgcctttt   1080
 aggaggaaat aaagagggaa gatttgcaat ccaactaaag aagagagatt tccagcgatc   1140
 cacaaagtcc gattgctatt ggctctcagc cagtgctcac tgttggggac aacccacata   1200
 tccaaattga cagatgacca actcataaaa gagtttctta gtggttctta ctgctttccg   1260
 tgggggtgtc ggttggtgga aatatgaatt ctgctatggc aaacatgtac atcaatacca   1320
 tggaggacaa ggatagtggg aaaaccctct gtgggttgtc gggaccatgg aacccaagaa   1380
 gagccatatt gaatgggcct aagaagaata cctgcctaga gccttatcat ccttcaagac   1440
 cgatggtacc ccagaccagt cagggatggg tgtcaccatt tttatggaaa tggagatatt   1500
 tgtgatataa cttgacaaac caagacaagg tgactgtaaa acctaaagtg caaagaatca   1560
 gattcacctc atgctgttac tgtatatatg ctagagcctc actcctgtca atatattctt   1620
 gggggtttga atctcccagt tgatctgtaa aatctttaga taccagcaga atgaaaaatg   1680
 gacttccttt ctcctcccca acttaaagga tattaaagtt tagggggaaa gaaaaagatc   1740
 attggaaagt ccatggataa tttcctggtc cccactggtg gtcctcatta taggaggttc   1800
 cccagcccat tgggcctctt ccaaaggatg ggataaaatg gctccccaac cactttgtga   1860
 atacatatgt gtatataaga ggttattgat aaacttctga ggcagacatt tgtctcgctt   1920
 tttttcattt ttgttgtgtc ttataaactg actgtttttc tttgcttgga tactgtgatt   1980
 ccaaaataaa tctcatccaa gcaagttaga gtccagccta atcaaaatgt cataattgtt   2040
 gtacctattg aaagttttta aataatagga tttattatgt aaattatagg tattatgtaa   2100
 ggtaggctaa tggaaggtaa agatcattga agaaagaaat tggataggtg taaatggaga   2160
 gaccatgtaa aatatggtaa attcctagta ccctgaaatc ctttccaacc agatttttaa   2220
 tataggcaac tgctctctgc caaagtagtt aaacttagaa actggggcac atgggtagag   2280
 gctcacatgg ggagttgtcc tcacccttgt taatctcaag aaactcttat ttataatagg   2340
 ttgcttctct ctcagaactt ttatctatta ctttttttct tcttatgagt atgtttactc   2400
 tcagagtatc tatctgatgt agacagttgg tgatgcttct gagactcgag aatggtttac   2460
 tctaacaaaa cactgggcct gctatcccct gtacctggct accggtatat gggattccac   2520
 cttccggaac agtttacatg cacaatattt attttaaagt gaataaaatg tccacaagca   2580
 gtgttgtcat gtagtcaatg gcagatt                                       2607



      <210> 499
      <211> 1150
      <212> DNA
      <213> Homo sapiens


      <400> 499
 caggagagcg tctaggaaat cgtctagaat gggacactgg cgccttctta ctgctgatac     60
 gacaggaatg tgcgctatct ttaggaaatg acaccgaact ggcagccggc gcctttggag    120
 ccggccctcg ctttgctgaa gacgagcagc tcccaccaaa gtcttgcctc cccttacccc    180
 gaaagccccg ctcagttcaa tatttcaagt gaaaatctgc ctgttcgaaa agaaaatatt    240
 cacaaatgag cagtgtatta gaagacaact gaattgcttc taagaatggg tctcactctg    300
 ccatcaccca ggctggagtg tggtggcacc atcatggctc actgcagcct tgaactcctg    360
 agctcaagtc atcctcccac ctctgccttc cgagtagctg gaactgcagg tgtgagccac    420
 catgcctggc tggatttgtc tttttaaatt ttttatagag accgagtctc aactatattg    480
 gtccagggct ggaaaagaac ttctttccct ccaagtgata accttttccc agacaagtca    540
 gcttaaaaac tgacccaaag gccctgaagt acacagtttt cttggagaaa gaaaaaaata    600
 agtgaaaagg acttgctgac ttgctaattc attttggggc ctgtgggtaa catcagaatg    660
 gcaaagcact tggggctttt tttctaattt gaattttttt aatcttatga gaaatgactt    720
 ttatatgcca agattcattc catagattag tttttatgac caagttaatg aacgcttttg    780
 aatatgggga cctagaatag aaatgctaac ctacctgcaa ggagagctct gtgattggca    840
 tccccatcat gctgtaactg acacaaaata aacttagggt aattgccgca tagtgtaact    900
 tttaatgtgt gagcatactg taacatttga caagcttttt gatttagatc agcaatgtgt    960
 aacccattca ttgttgtcac tctcaacaag gccttatggt caaacatcat cactctccct   1020
 aaaaagatag tttactgaaa tatactgaga ttttgaaact ggagtcaaga ggtagcaccc   1080
 tgttttatgt tgatccattt aatggtcctt gacagccaat aaaaagaccc tggaagaaaa   1140
 aaaaaaaaaa                                                          1150



      <210> 500
      <211> 991
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(991)
      <223> n = a,t,c or g


      <400> 500
 aaaggatact ctccaaaaag ttcgagaaaa tctagataga cgctaacagg aattggaaaa     60
 taacacccct ggtaccaaaa catgtttaac tggaatctat ggctaactac tctaatcact    120
 ggattggcgg gaccccttct cctcctcttg ttaggtttag tcttcgggcc ttgtatatta    180
 aattggtttc ttaaatttat aaagcagttc atagcttctg tcaaacttac gtatcttaaa    240
 acccaatata actcccttgt tgtgactgaa gaatcaatga tttgattacc caaaacatga    300
 gtggggaatg tgatacctac cctgttttaa cctgccccaa gtttacgtgt acagtgggtc    360
 agaagggtga cttctgaccc ttctgctcag agtgactctc tcttagctga gatagctgga    420
 cactctccat tttagcttct tcacttgcag tccccttatc cccctccctt aagggaataa    480
 ctagtgcaag ctgactccaa gcacatccag gaatgcactt actgataaga tattgaggca    540
 agctgtacca gcagctcctg gggacgtgct cggcggatgg tacccaagcc cctgcattta    600
 tctctttgtg atagtttaag cccctgcacc tggaactgta tttttctgta actatctctg    660
 taaccattaa tttttttaac tttttgcctg ttctgcttct gtaaaaattg cttcaagtag    720
 gctccccctc ccctatttag accatggttt aaaaagaaat ctatcccgtt cttcgaggcc    780
 aagagaattt tgagctctag ccatctctcg gtcgccggca ataaaaggac tcctgaatta    840
 nncnnannnn nnnnnnnnnn nnnnnnnnnn nnnnccccca aaaaaanngg gggcgccggc    900
 ttaaaaaaaa actttggggg ggcccacttt tatccaggga gaccacaagg ggtttatctt    960
 tttctctttg ggggggggat aaaaataact t                                   991



      <210> 501
      <211> 369
      <212> DNA
      <213> Homo sapiens


      <400> 501
 atctggtcga tcgtttcctg gccctcgcct cctgcgctgt gtccctggaa ttcttgcacg     60
 tcgcccaaga tgtctgatgc tgacgttgag aaagctgcca aggatgttac gcaccttaag    120
 accattcctt cggatgagga gatgctgctc atctatggcc actactatca agcaactggg    180
 ggcgacataa atacagaacg ggccggcatg ttggacttca ctggcaatga cacgtgggat    240
 gcctggaatg agctgaaagg gacttccaag gaagatgcca tgctagctta catcagcaaa    300
 gttgtatagc tattgaaaaa atacgggata ttgagagact ggacttgata ctgtgccatg    360
 cgatatgcc                                                            369



      <210> 502
      <211> 648
      <212> DNA
      <213> Homo sapiens


      <400> 502
 gccgctcctt ggtgggggct gttcatggcg gttccggggt ctccaacatt tttcccggct     60
 gtggtcctaa atctgtccaa agcagaggca gtggagcttg aggttcttgc tggtgtgaaa    120
 tgactgagta caaactggtg gtggttggag caggtggtgt tgggaaaagc gcactgacaa    180
 tccagctaat ccagaaccac tttgtagatg aatatgatcc caccatagag gattcttaca    240
 gaaaacaagt ggttatagat ggtgaaacct gtttgttgga catactggat acagctggac    300
 aagaagagta cagtgccatg agagaccaat acatgaggac aggcgaaggc ttcctctgtg    360
 tatttgccat caataatagc aagtcatttg cggatattaa cctctacagg tactaggagc    420
 attattttct ctgaaaggat gatctttgtg ttctgaatct ttatggggaa atgaggttac    480
 cacactaggg aagatagagc tttttaatta tgggaagagt tggttttagg ttgtttgaca    540
 ttgagaatct agggtaatta ctgaaagtta atactggaat ttattttaca taatatactg    600
 ttactataaa gtttgataat acgtaagtga agcttgctac tgggaatg                 648



      <210> 503
      <211> 1360
      <212> DNA
      <213> Homo sapiens


      <400> 503
 tttcgtgtgg ttccgaggct gactaccctg cggcggcgcg gctcgcagtc cttctcagca     60
 tggaccgcac ttgtgaggag aggcccgctg aggatgggag cgacgaggag gacccagact    120
 ccatggaagc cccaacccgg atccgggaca ctccggaaga catcgtgctg gaagctccgg    180
 ctagtgggct ggcgttccat ccggcccgtg acctactggc tgcaggggac gtggacgggg    240
 acgtgttcgt cttttcctac tcttgccaag agggagaaac caaggagctc tggtcatcag    300
 gtcaccatct caaggcctgc cgagctgtgg ccttctctga agatgggcag aagctcatta    360
 ctgtctccaa ggacaaagcc atccatgttc tagatgtgga gcagggccaa ctggaaagac    420
 gtgtttccaa ggctcatggt gcccccatca atagtcttct gctggtggat gagaatgttc    480
 tggccactgg ggatgacaca ggtggtatcc gtctctggga ccagcggaag gagggcccct    540
 taatggatat gaggcaacat gaagagtaca tcgcagacat ggctctggat ccagccaaaa    600
 agctgctgct gacagccagc ggggatggct gccttggcat cttcaacatt aagaggcgtc    660
 ggtttgagct gctctcagaa cctcaggctg gggacctgtc ctctgtcact ctcatgaaat    720
 gggggaagaa ggtagcctgt ggctccagtg aaggtaccat ctacctcttc aattggaatg    780
 gctttggggc cacaagtgac cgctttgccc tgagagctga atctatcgac tgcatggttc    840
 cagtcaccga gagtctgctg tgtactggct ccactgatgg agtcatcagg gctgtgaaca    900
 tcctaccgaa ccgagtggtg ggcagtgtgg gccagcacac tggggagcct gtggaggagc    960
 tggccctctc ccactgtggc cgcttcctgg ccagtagtgg ccatgaccag cgcctcaagt   1020
 tttgggacat ggcccagctt gcgagctgtg gtggtggatg actaccgtcg gcgcaaaaaa   1080
 aagggaggac cactgcgggc tctgagcagc aagacttgga gcaccgatga cttcttcgca   1140
 ggactgaggc aagagggaga agcctccatg gctcacagaa gaaaaggagg agactgggga   1200
 tgacagtgac tgaaggaatg aattgaatct tgagacgggt cctcaccagg caagagtctt   1260
 gcttattggg ctgcatcccc agagaggata tgaattattt tttaaaagac agggtctgtt   1320
 tgcgccgctc tgaggatcaa gcttcggcgc gtgcatagag                         1360



      <210> 504
      <211> 1133
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1133)
      <223> n = a,t,c or g


      <400> 504
 tcgtagacat tagtccacgt ggtggaattc gaggacagag cggcccggtc gccggcatgg     60
 tttctccgtc ctgctgcagc cggcgggagg cagccagtcc agtgcgcccg ctagcttcgg    120
 cggcgaccca gacggggaaa gcggaaggaa tgtcgcgtgc aagcatgcag ctggtgtgga    180
 agaatggcgg tgagccattc agtgaaagag cggaccatct ctgagaacag cctgatcatc    240
 ctacttggag ggcctccagg gccgtgtaac cactgtggac ctgcgggatg agagcgtggc    300
 ccacggacgc atatacaatg gcgatgcttt catgaacatc cgcctggcca aagtcaccta    360
 cacggaccgt tgggggcatc aggtcaagct ggatgacctc tttgtgacag gccgcaatgt    420
 ccgctacgtc cacatcccag atgacgtgaa catcacctcg accattgagc agcagctgca    480
 gattatccat cgggtgcgaa actttggtgg caagggccaa ggccggtggg aatttccccc    540
 aaaaaactgt aagtgaggcc ctcagcaagc cctggcccca actcggagtc ctccagtgat    600
 ctccggagct agttccctgc cctcacaccc tgtctggtac ccgagaagaa agcagggcca    660
 ggccagaagc tggtgtccaa cagacaccac ctgtcaaagc tgcctttcac agggttccac    720
 ctcccagact cactctggga cccagaatcc tatatgtggc cttggggtag gtgacaatcc    780
 ccctttttga tgatctgaat ttctgactta ttgattatgg aacctgtcaa gtagttttca    840
 actctcccag tgaggataat taaacatgct cagcctgagc cacctctaag tgtctccatt    900
 tctcatgcag ttgtgttcat tttctcatga aacccaactt ggatacaaac aggtccgtgc    960
 cccaggcttt cccttctgtg tgctgcgctc ccaggccatc ctgtgtagtc gggggcagan   1020
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn tcccaccctc acagattcat atttcattgg   1080
 tatggggtat ggtctgaggg ctatgagttt ttttaatttc ccaggcgtgt att          1133



      <210> 505
      <211> 621
      <212> DNA
      <213> Homo sapiens


      <400> 505
 gctgcaggaa gcttataatt tggctaatta tccaccttaa tcaccatgaa aatttataag     60
 gatcttatta ctgatgatga acttttctca gacacctatc ccatgaaact tattgatggt    120
 gtaatctatg aagtaacagg aaggcttgtc actcgtaaag ttggagatgt ccagttaatt    180
 ggttctaacc cttctgctga agatgttgat gaaggaactg aagaagcagt tgaatcagga    240
 tgtgatatag ttctgaatca tagactacaa gaaagttatg cttttggtga taaaaaggga    300
 tacaccttgt atttgaagga atatatgaaa aggattgttg ataagcttca agaaacgaat    360
 ccttcagaag tagacacatt taaaactaac attaataaat atatgaagga tgtccttgga    420
 aggttcaagg atcttcaatt ctttactggt gaatctacag acatagatgg catggtcgct    480
 cttcttgaat acagagattt aaacggtgaa agcagacccg tgatgatgtt tttcaagcat    540
 ggccttattc aagaaaaatg ctaatgtatt ccaattgtta acaccttttg ttattcttgg    600
 aaacaaaggt ctttgaaagc c                                              621



      <210> 506
      <211> 425
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(425)
      <223> n = a,t,c or g


      <400> 506
 ctcgcggaat tccgcacgag ggaatatgct ggcccttcgt cagattgccc agaggaccat     60
 cagcaccact tcacgaaggc attttgaaaa caaggttcca gagaaacaaa agctgtttca    120
 ggaggataat gggatgccag ttcatctgaa aggcggggca tctgatgccc tcctctacag    180
 agccacaatg gctctgacgc ttggtggcac agcctatgcc atctatctgt tagctatggc    240
 tgcatttccc aagaagcaga actaatgtcg tcatcccagt cttcacgtgg ttcagtttca    300
 tcaacgctcg atggaccagg aatctgatga gtaactgagc tcttctttgg ggatcaatat    360
 ttattgatgt gtattaactg ctgccaataa agcaatcctt aaccattnnn nnnnnnnnnn    420
 nnnnn                                                                425



      <210> 507
      <211> 1184
      <212> DNA
      <213> Homo sapiens


      <400> 507
 ggatcgggga attctgctgg cgctgcagct gcagaatggt cggcggtggc gggaagcgca     60
 ggcccggcgg ggaggggccg cagtgtgaaa aaacaactga tgtgaagaaa agtaaattct    120
 gtgaagctga tgtctccagt gaccttcgaa aagaagtaga aaatcattat aagctttctt    180
 tacctgaaga tttctatcac ttctggaagt tctgtgaaga acttgatcct gaaaagccat    240
 ctgattcact ttctgcaagc cttggacttc aattagttgg tccttatgat atccttgctg    300
 gaaaacataa aacgaagaaa aaatcaacag gcctgaattt taaccttcac tggaggtttt    360
 actatgatcc tcctgagttc cagaccatta ttattggaga taataaaact cagtaccaca    420
 tggggtattt cagggattct cctgatgaat ttcctgtata tgttggtata aatgaagcaa    480
 agaaaaattg tataattgtt ccaaatggag ataatgtatt tgctgcagtc aaattatttt    540
 tgacgaaaaa acttaaagaa ataacggata aaaagaaaat caatctcttg aaaaacatag    600
 atgaaaaact cacagaagca gccagagaat tggggtactc gcttgaacag agaaccgtga    660
 agatgaaaca gagagataag aaagttgtga caaagacctt tcatggtgca ggcttggttg    720
 ttccagtaga taaaaatgat gttgggtacc gagagctccc tgaaacagat gctgacctca    780
 agagaatttg caagacaata gttgaggctg caagtgatga ggagagacta aaagcttttg    840
 ctcccattca ggaaatgatg acttttgtgc agtttgctaa tgatgaatgt gattatggca    900
 tggggcttga attgggaatg gatctctttt gctatggctc acattatttt cataaagttg    960
 ctggccagct tttacctctt gcatataatc tgttgaagag gaatctgttt gcagaaatta   1020
 ttgaggagca tctggcaaac agaagtcaag agaacataga ccaacttgct gcatgagtaa   1080
 ggtggctttg attggtgtac agtatttcaa aggactagta ttaaacttgt gatttttgtt   1140
 ttgtttttaa ggaatacaaa aaataaacat ttactaaaaa cgtt                    1184



      <210> 508
      <211> 1189
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1189)
      <223> n = a,t,c or g


      <400> 508
 ggcacgagga acgaaagatg gcggcgcccg taaggcggac gctgttaggg gtggcggggg     60
 gttggcggcg gttcgagagg ctctgggccg gcagtctaag ctctcgcagc ctggctcttg    120
 cagccgcacc ctcaagcaac ggatccccat ggcgcttgtt gggcgcgttg tgcctgcagc    180
 ggccacctgt agtctccaag ccgttgaccc cattgcagga agagatggcg tctctactgc    240
 agcagattga gatagagaga agcctgtatt cagaccacga gcttcgtgct ctggatgaaa    300
 accagcgact ggcaaagaag aaagctgacc ttcatgatga agaagatgaa caggatatat    360
 tgctggcgca agatttggaa gatatgtggg agcagaaatt tctacagttc aaacttggag    420
 ctcgcataac agaagctgat gaaaagaatg accgaacatc cctgaacagg aagctagaca    480
 ggaaccttgt cctgttagtc agagagaagt ttggagacca ggatgtttgg atactgcccc    540
 aggcagagtg gcagcctggg gagacccttc gaggaacagc tgaacgaacc ctggccacac    600
 tctcagaaaa caacatggaa gccaagttcc taggaaatgc accctgtggg cactacacat    660
 tcaagttccc ccaggcaatg cggacagaga gtaacctcgg agccaaggtg ttcttcttca    720
 aagcactgct attaactgga gacttttccc aggctgggaa taagggccat catgtgtggg    780
 tcactaagga tgagctgggt gactatttga aaccaaaata cctggcccaa gttaggaggt    840
 ttgtttcaga cctctgatgg gccgagctgc ctgtggacgg tgctcagaca agtctgggat    900
 tagagcctca aggacattgt gtgattgcct cacatttgca ggtaatatca agcagcaaac    960
 taaattctga gaaataaacg agtctattac tgnnnnnnnn nnnnnnnggg ggggccgttt   1020
 taaaggatcc aattttactt ccgcgggctt gcaaggtaat actttttttt tggggccccc   1080
 aaaattcaat tccccgggcg ggggtttaac accgtgggga ggggaaaaac ctgggggttc   1140
 cccaatttaa tggctttgaa gaaaatcccc ttttcgccag ggggcaaaa               1189



      <210> 509
      <211> 437
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(437)
      <223> n = a,t,c or g


      <400> 509
 actatctgga atttggtcgt ccctggcagg aatttggcac gagccacttt cttgggacag     60
 tgaatcaaca atgccgtctt ctgtctcgtg gggcatcctc ctgctggcag gcctgtgctg    120
 cctggtccct gtctccctgg ctgaggatcc ccagggagat gctgcccata agacagatac    180
 atcccactgt gcccctgctc tggctaagtt tttatatttt tggactttta atacaatagg    240
 gtttcaccct gttcattgtc gtccttgttt tctgagacag agtttttctc tgtcgcccag    300
 gctgggagtg cagtaacgtg atctagaccc acttgcaacc tccgtctttc ttgggttcaa    360
 ggcgatttct cctgcctcaa gcctcttgag taagctnggg gactacaaag caactnccaa    420
 caaaacggnt aaatttt                                                   437



      <210> 510
      <211> 865
      <212> DNA
      <213> Homo sapiens


      <400> 510
 tgatccctag tccagtgcgg tggaattcgg agttgctcta ggtcgtaacc agcctttgaa     60
 aaaggagaaa ccaaaatgga aaagcgatta tcctatgaca gatggacaac tacgcagcaa    120
 gagggatgaa ttttgggata cagcaccagc ttttgaaggc cggaaagaga tttgggatgc    180
 cttgaaggct gctgcacatg cttttgagag caatgatcat gaactggcac aagcaatcat    240
 tgatggtgca aacataacat taccacatgg tgcacttaca gagtgctacg atgaactggg    300
 gaacagatat cagcttccag tgtattgctt ggcaccgcca atcaacatga tagaggaaaa    360
 gagcgacata gagactctgg atattcctga gccaccaccc aattctggat atgaatgtca    420
 gcttcgtttg cgcctttcca caggcaaaga cctcaagctt gtggttcgca gcacagacac    480
 agtattccac atgaagagac ggttgcatgc agcagaggga gtggaaccag gtagtcagcg    540
 gtggtttttt tctggcagac ctctcactga caaaatgaag ttcgaagagc tgaagatccc    600
 aaaggactat gttgtacagg ttatagtgag ccaacctgtg cagaacccaa caccagtgga    660
 gaactgaact gagccctgtt ggccagctcc cacatccctc tgctcctttt tatggttctt    720
 gttgtcattt cctactctgc ggcgtgaaat ctatttcact gctctaaatt ccctatgaat    780
 ggatttagtt ctgaggaatt accagtgaaa aattccatct gtgatggaga ccaacaaaaa    840
 taataaaaca caaagagcca gaaaa                                          865



      <210> 511
      <211> 1316
      <212> DNA
      <213> Homo sapiens


      <400> 511
 tacagcgcgg cggaaccggt ctggtccagt cggtcttcct ccggcccggg ccctggccca     60
 gttagccgtc caaggaaggt aatggccccg ctgcggacca ctaccagccg gccagccccc    120
 cgcgggacgc ctgcgtgtac agcagctgct actgtgaaga aaatatttgg aagctctgtg    180
 aatacatcaa aaaccatgac cagtatcctt taaaagaatg ttatgctgtc ttcatatcta    240
 atgagaggaa gatgatacct atctggaaac aacaggcgag acctggagat ggacctgtga    300
 tccgggatta ccatgttgtt ttgcttcatg tttcaagtgg aggactgagc ttcatttatg    360
 atctcgatac tgtcttgcca tttccctgcc tctttgacac ttatgtagaa gatgccatta    420
 agtctgatga tgacattcac ccacagttta ggaggaaatt tagagtgatc tgtgcagatt    480
 catatttgaa gaactttgct tctgaccgat ctcacatgaa agactccagt gggaattgga    540
 gagagcctcc gccgccatat ccctgcattg agactggaga ttccaaaatg aacctgaacg    600
 atttcatcag tatggatccc aaggtaggat ggggcgccgt ctacacacta tccgaattta    660
 cacatcggtt tggcagtaaa aactgctgaa cttggtctca agatgtggaa ctgtggaaga    720
 aattctagga catgaacaag ctatcctttc atcgaggaca gcaaacatta tggtacagtt    780
 ggcttggaat tatgtctttc tcttttaatt tgattgagtg gaaatctgag tgagtacaaa    840
 tattaaatga acaacataaa aactttttgt gttgacatgt caaattgaaa cttgataaag    900
 tgcgtacttg ctaagatatt cctgtggctc atgcgttaca acacgaggac ttaagccagt    960
 aatcgttttt gttcagatag aggtgtggaa gtagagccag cccctcatgt ctgttttgga   1020
 tgttttgtgt ctctccagct acattggtaa gttccttgag gggcagggcc atggcccatt   1080
 gctctgtgaa tctcaaatgc ccataaaagg gtggcccata aaatgttttc ttgaacattt   1140
 gaattgtgct gttgtctgga aagggggtaa tattgtgagc tgaatcagca ataaggtatt   1200
 agtctttttg gactatggta ttgttaaaaa gactgcagcc ctctcagact tgagcgttaa   1260
 ttggcttatt tatttatggc tttaaataaa atcgatttaa cgttaaaaaa aaaaaa       1316



      <210> 512
      <211> 672
      <212> DNA
      <213> Homo sapiens


      <400> 512
 acctcttctc ataccctgtg ctaacaactt ttaacaaaaa atttgcatca cttttaagaa     60
 tcaagaaaaa tttctgaagg tcatatggga cagaaaaaaa aaccaaggga aaaatcacgc    120
 cacttgggaa aaaaagattc gaaatctgcc tttttataga tttgtaatta ataaggtcca    180
 gggtttctaa ggcaacttaa atgttttgtt tcggaaacaa agtacttgtc tgggatgtag    240
 ggagggaaag gggagtgatg ttcacttgcc attatggtgg ccccttggaa tataagaccc    300
 tacttggcta tcttcccctg gcaccagcca gggagccacc ccatcctcca gcacactggg    360
 gcagcaagct gggacacacg gcacactgga tcccaaatgg gtaaggggat gggtggcgat    420
 gctcattctg ggtctgctac ttctggcgct gctcctaccc gtgcaggttt cttcatttgt    480
 tcctttaacc agtatgccgg aagctactgc agccgaaacc acaaagccct ccaacagtgc    540
 cctacagcct acagccggtc tccttgtggt cttgcttgcc cttctacatc tctaccatta    600
 agaggcaggt caagaaacag ctacagttct ccaacccata cactaaaacc gaatccaaat    660
 ggtgcctaga ag                                                        672



      <210> 513
      <211> 1188
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1188)
      <223> n = a,t,c or g


      <400> 513
 tgggccccaa gcccaaatta aatgaacctg cgggggtttt ccggattttc catttataaa     60
 tttgggaatt tcggcccggt ttaccaaagg ggnnnnnnnn nnnngcgggt tgcccctttt    120
 ttttcnnnnn nnnnnnnngg aaccgcggtt gtttaaaagc ctgagggaac ctggagaggg    180
 gctcccactc cctaccttct ttcctccgag tttgtgactc cgagatggac aaagtgtgtg    240
 ctgtttttgg aggctcccga ggcattggca gagctgtggc ccagttaatg gcccggaaag    300
 gctaccgact ggcggtcatt gccagaaacc tggaaggggc caaagccgcc gccggtgacc    360
 tcggcggaga tcatttggca tttagctgtg atgttgctaa agaacatgat gttcaaaata    420
 catttgaaga gatggagaaa catttaggtc gagtaaattt cttggtaaat gcagctggta    480
 ttaacaggga tggtctttta gtaagaacaa aaactgaaga tatggtatct cagcttcata    540
 ctaacctctt gggttccatg ctgacctgta aagctgccat gaggactatg attcaacaac    600
 agggagggtc tattgttaat gtaggaagca ttgttggctt aaaaggcaac tctggccagt    660
 ccgtttacag tgccagtaaa ggaggattag ttggattttc acgtgctctt gctaaagagg    720
 tagcaagaaa gaaaattaga gtgaatgtag ttgcaccagg atttgtacac acagatatga    780
 cgaaagactt gaaagaagaa catttaaaga aaaatattcc tcttgggagg tttggagaaa    840
 ctattgaggt ggcacatgcg gttgtgtttc ttttagaatc accgtatatt acagggcatg    900
 ttctggtagt ggatggggga ttacaactca ttttgtaatt tgcagattat tcagttatag    960
 gggtgattag catcaagggc acactttggc tactgattag acaattatac ctacatgggt   1020
 aacatgtgct aatcaaacct gctgatgcta caaatgttaa tttctgtctt tataaaaata   1080
 tgtctcaaaa gaacaatgtg tgacaaattg tggttttttt ttttttggcc aaactaacat   1140
 cagggtggtt ttgttaaaaa agcctttttg aaatccaatt cacataca                1188



      <210> 514
      <211> 1052
      <212> DNA
      <213> Homo sapiens


      <400> 514
 atagagacct tcgagctcca tagtcagtgt ggtggaattc gtcaccagag aagtcttggt     60
 ggaaacgtat gaagagagtg tgcctgtgtc cagttaccag caggcaggaa ttcccgtgga    120
 cttgaaaagg aagattgcac ggctggggat caacatgctc ctgaagatga tatttgtgga    180
 taactttgtc catgcagacc ttcaccctgg aaacatcctg gttcagggtg ccaacggcct    240
 gtcctcgagt caggaggcgc agctgcagca ggcggacatc tgtgacactc tggtggtggc    300
 cgtgccatct tccctctgcc cgctgcgact ggtgctgctg gatgctggca ttgtggcgga    360
 gctgcaggcc cctgacctga ggaatttccg ggcagttttc atggctgtgg tgatggggca    420
 gggccagaga gtggctgagc tgatcctgca tcatgcccgg gccagcgagt gcagggacgt    480
 ggaggggttc aaaaccgaga tggccatgct ggtgacccag gccaggaaga acaccatcac    540
 cctggagaag cttcatgtgt ccagccttct ctctagtgtc tttaagttgc tgatgactca    600
 caaggtaaag cttgagagca actttgcctc cattgtgttt gccatcatgg tgttggaggg    660
 gcttggccgc tcactggacc ccaaactgga catcctggag gcagcgaggc ccttcctcct    720
 cacgggccca gtgtgccccc cgtgatgggg cagtggcctc tgtgggccct tgtcaagagc    780
 tggaggccac tcccaagagc ctctcctatg gcagctggga cgttttaaaa ttgggacacc    840
 aatttcaaat gtaaccctcc agtggtggaa ggcacaccat ggcttcctct gcttggtttg    900
 agggtctgtt caaaagcttt gggccaatta gggagtaaaa ggagggaagg ggcctatcca    960
 ttccattgtg gaagctgggc caggtgccag ggacactctc cttcagggaa aatgttatgt   1020
 ggaggaggac gaataaattt attttgtttt cc                                 1052



      <210> 515
      <211> 1187
      <212> DNA
      <213> Homo sapiens


      <400> 515
 tttcgtggaa gctgatgtgt tattccttct ctgcatcgaa ggatcaggaa gtttgtgctc     60
 tctgcgtggc taagtttttc acctactagg acgggggtgg ggtggggaga acaggtgtcc    120
 ttctaaaata cagcacaagc tacagcctgc gtccagccat aacccaggag taacatcaga    180
 aacaggtgag aatgaccact ttaactcacc gggcccgtcg cactgaaata agcaagaact    240
 ctgaaaagaa gatggaaagt gaggaagaca gtaattggga gaaaagtcca gacaatgaag    300
 attctggaga ctctaaggat atccgcctta ctcttatgga agaagtattg cttctgggac    360
 taaaagataa agaggggtac acatctttct ggaatgactg catatcatca ggcctgcgag    420
 ggggcatcct gatagagctg gccatgcggg gtcgaatcta tctggaaccc ccgaccatgc    480
 gtaagaagcg actactagac agaaaggtac tgctaaagtc agacagccca acaggtgatg    540
 ttttactgga tgaaactctg aaacacatca aagcaactga acccacagaa actgtccaaa    600
 catggataga gctactcact ggtgagacct ggaacccctt caaattacag taccagctga    660
 gaaatgtacg agagcgcatc gcaaagaacc tagtagagaa aggtattcta accactgaga    720
 agcagaattt cctgctattt gacatgacta ctcatccagt gaccaataca acagagaaac    780
 agcgactagt gaaaaaactt caagatagtg tactagagcg gtgggtaaat gaccctcagc    840
 gtatggacaa gcgaacacta gcactcctgg tgctagccca ctcctctgat gtgctagaga    900
 atgtcttctc ctctctgaca gatgacaagt atgatgtggc aatgaatcga gccaaggact    960
 tagtagaact ggaccctgaa gtggaaggga caaagcctag tgccacagaa atgatctggg   1020
 ctgtgctggc agccttcaat aaatcttaaa gccggcaggt ggatttctcc ttttcccctg   1080
 ctggctgggg actgtcagag accccatcac tgagttttgt gtgatgagat gttttcatca   1140
 attttggttc cttttctttg atcaaactgt gaattgggag agcaatt                 1187



      <210> 516
      <211> 1663
      <212> DNA
      <213> Homo sapiens


      <400> 516
 tttcgtcact gtgtcccacc cttcctagct ttgtgcccgg ggtgctgagc ccttccccgt     60
 cagccgggcc gcgggaggag ggagccgcca ccgaggagct gccgctcgct gccccgggca    120
 ggggcacagg ttgatgtcat atttttagtc ttgagaaaca gcatcatgcc aaggaaagag    180
 cttgagcttt ggagtaatgc ggccctgaga ttgaattctg gctatgccac ttattagctc    240
 tgttctagat tgcaaccaag gcaatgtctt actacctcag ctcagaaaac cacctggacc    300
 cagggcccat ctacatgcga gaaaatgggc agctgcacat ggtcaatctg gctctggatg    360
 gtgtcaggag tagcctgcag aagccaaggc ctttcagact gttccccaaa ggcttttctg    420
 tggagctttg catgaacagg gaagacgaca ctgcacggaa agagaagact gatcatttca    480
 tcttcacata cacccgagag gggaatcttc ggtactccgc caaatccctc ttcagccttg    540
 tcctgggttt catctccgac aatgtggatc acattgattc ccttattggc tttcctgagc    600
 agattgctga aaagctgttc tctgctgctg aagccagaca gaaattcact gagccaggtg    660
 cagggctgag ggctttacag aaattcactg aggcctatgg aagtttggtg ctttgctccc    720
 tgtgtttgcg aaacaggtat ctcgtgattt cagaaaagct tgaggagatt aagtctttcc    780
 gggagctgac ctgcctggat ctttcctgtt gcaagcttgg agatgagcat gaacttctag    840
 aacatctcac caatgaagcc ctgtctagtg taactcagct ccacctgaag gataattgtt    900
 tatctgatgc tggggtgcgg aagatgacag caccagttcg agtgatgaaa agaggccttg    960
 agaatctaac attattagac ttatcatgta accctgacat cacagatgca ggcattggat   1020
 acctcttttc ttttaggaaa ctaaactgct tagatatctc tgggacaggg ctcaaggaca   1080
 tcaaaaccgt caagcacaag ctccagaccc acataggcct tgttcactcc aaagtgcctt   1140
 tgaaggaatt tgatcatagt aactgcaaga cagagggctg ggctgaccag atcgttctgc   1200
 agtgggagcg tgtgactgcg gaagctgtga agccacggga gacctcggag cctagagcag   1260
 cagctcagcg cttctatggg aagcggtctc gagcagaagc cccactgaag tgtcccctgg   1320
 cagacaccca catgaactct tccgagaaac tccagttcta taaagagaaa gccccagatt   1380
 gccatgggcc agtgttgaaa cacgaagcta tctcaagcca ggagtcaaag aagagcaaga   1440
 agagaccttt tgaggagtca gagacagaac agaataactc ttcacaacct tcaaagcaga   1500
 aatatgtatg tcttgctgtg gaagactggg acttgttaaa ttcctattga ttagtagata   1560
 caagttgacc tttctctggc ccccagctct agtgtttgag taaaggagac tgaggatgat   1620
 ttactttttg gttggaatta cctatggcat tagcatagta agg                     1663



      <210> 517
      <211> 464
      <212> DNA
      <213> Homo sapiens


      <400> 517
 cggcagcgtc gacgtcaccg ccatggctgc cccgtgtttg ctgcggcaag gacgagccgg     60
 ggcgctgaag actatgctcc aggaagccca ggtgtttcga ggacttgctt ctacggtttc    120
 tttgtctgcg gaatcaggga agagtgaaaa gggtcagcca cagaattcca agaagcaaag    180
 tccaccaaaa aagccagccc cagtgcctgc tgagccgttt gacaacacta cctacaagaa    240
 cctgcagcat catgactaca gcacgtacac cttcttagac ctcaacctcg aactctcaaa    300
 attcaggatg cctcagccct cctcaggccg ggagtcacct cgacactgag ggccctcggt    360
 gtgaagatga accttccacc gtcttcactg catcctggag tgcaaaaata aaatccactc    420
 aagagtcaca aggcccgctg tgcataatcg gtttcacttt tacc                     464



      <210> 518
      <211> 464
      <212> DNA
      <213> Homo sapiens


      <400> 518
 cggcagcgtc gacgtcaccg ccatggctgc cccgtgtttg ctgcggcaag gacgagccgg     60
 ggcgctgaag actatgctcc aggaagccca ggtgtttcga ggacttgctt ctacggtttc    120
 tttgtctgcg gaatcaggga agagtgaaaa gggtcagcca cagaattcca agaagcaaag    180
 tccaccaaaa aagccagccc cagtgcctgc tgagccgttt gacaacacta cctacaagaa    240
 cctgcagcat catgactaca gcacgtacac cttcttagac ctcaacctcg aactctcaaa    300
 attcaggatg cctcagccct cctcaggccg ggagtcacct cgacactgag ggccctcggt    360
 gtgaagatga accttccacc gtcttcactg catcctggag tgcaaaaata aaatccactc    420
 aagagtcaca aggcccgctg tgcataatcg gtttcacttt tacc                     464



      <210> 519
      <211> 363
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(363)
      <223> n = a,t,c or g


      <400> 519
 aaaagnttat cgnngggggg gggaatatgg actttatggc tcaagtgcaa actctgatga     60
 tgaccagtca gtttgaggct gcattgaaga aggcgaacct gaaaggctac ggccgataat    120
 tggccgccct agaagctacg gagagtaaaa atgaaagttc gtgcttccgt caaaaaatta    180
 tgccgtaact gcaaaatcgt taagcgtgat ggtggcatcc gtgtgatttg cagtgccgag    240
 ccgaagcata aacagcgcca aggctgattt tttcgcatat ttttcttgca aagttgggtt    300
 gagctggcta gactagccac ccaatctttt gaatgtctgt gcctttccat ttgaaaatcc    360
 cgg                                                                  363



      <210> 520
      <211> 642
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(642)
      <223> n = a,t,c or g


      <400> 520
 gggctcaatn tgccccgcgc aagtgctcgc cgggctatat cagcaaaggc agtcccgcga     60
 aacagcgagt gatgtcgtag ccactntggg agtgcagtga tgatgaagct gattaatcgc    120
 agtaagcaat cacctattgg tcgccgcgct tgcgatgttg cgctggcagc tcacttgcaa    180
 acatatggcg actatgggcg aagcaagatg aaagagactt atacggtgaa gttgaaaggc    240
 gtaaaagtct gggtggaggt ggtgaaccga aaggcgagct acgtggccac agcgatgacc    300
 ggcatgcgcc gtctccgctc cctgcccggg caggttggtt gaaaaagatt ttgaatggcc    360
 cgaacgggca actggagaga gctatggatg atattttggt aacgtcagac ctgaccagtc    420
 gctacaaaat ttcacgcaaa accctttggt catggcaaag tgcagacaca atgcctcggg    480
 gcttcgtatg cccgttccca ccccctgact ggcccggcaa ccctaaccgc tggcgctctg    540
 agtcaatcaa agagtgggag gataaaaaga agataaatta actgaagggc tctccgatga    600
 tctcttcaag atggctctgc caaacgcgga gccagtgttt ct                       642



      <210> 521
      <211> 1377
      <212> DNA
      <213> Homo sapiens


      <400> 521
 cggtggcatt cgaccgtctg gcaggccgcg tggcgcccgc gccggccttc ctgcagggga     60
 ctccaccgga gccttgccaa ttccgtttgt ttccctgttg tcgcccgctt caccctggat    120
 catgttcaag aagtttgatg aaaaggaaag tgtgtccaac tgcatccagt tgaaaacgtc    180
 agttattaag ggcattaaga gccaactggt agagcaattt ccaggtattg aaccatggct    240
 taatcaaatc atgcctaaga aagatcctgt caaaatagtc cgatgccacg aacatacaga    300
 aatccttacc gtaagtgggg aattattgtt ttttagacaa agaaaggggc ctttttgtcc    360
 aactctaagg ttgcttcaca aatacccctt tatcctgcca caccagcagg ttgataaagg    420
 agctatcaaa tttgtactca gtggcgcaaa tattatgtgt ccaggtttaa cttctcctgg    480
 agctaagctg taccctgctg cagtagatac gattgtagca gtcacagcgg aaggaaaaca    540
 gcatgctctg tgtgttgggg tcatgaagat gtctgcagaa gatattgaga aagtcaacaa    600
 aggaattggc attgaaaata tccattattt aaatgatggg ctgtggcaca tgaagacata    660
 taaatgagcc tcagaaggaa tgcatttggg gggctaaatg tggatattga ttgtgtcgta    720
 tgtgtgtttg tgtctgtgtg tgacagcgtg aatacaatgc ctctgtggtt atgctaaata    780
 agtttaacag atactttata gaaaacaaat cagggtgctc ttaccacaga tgaacaaaca    840
 aattagggga caagcagcaa gcagtctgct aacactctgg aatgtgaaag gagtgtctgg    900
 actctgtgac tcccggcaaa ctccacagcc tctagttgtc ttcttaggaa gcttggaagc    960
 aattgagaat ggtctaacat caagatgtct accacagggc cccccacaaa agcagcctcg   1020
 gggactccgg cctttccttg agacctgcat ctcttccctt cttcatcgcc tgctagcgaa   1080
 ctgaggctgc cgctaacctt cttcatcctt tggtggcaaa gtagaaagat tccagaatta   1140
 actcgacctt tctaaagacc tgggctcaga ggcagctggc actgactgag cacccactat   1200
 gtgccaggca ctgtgctgaa tgcattgtaa ggactgtctt acttattccc ccacagcagc   1260
 cctaagaagg ggtgctgtta tccccttttt acagataaga aaactgaagc tcagagaggg   1320
 cactgcattc cccaaggtca cccagctaca agtaacaaag cctgtgcttc taacacc      1377



      <210> 522
      <211> 2906
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2906)
      <223> n = a,t,c or g


      <400> 522
 agtgctgcct gcccgctggg tggtactgct acctagtggg tcttggggac cttcgaaatc     60
 gccgccgctc tcacaatggc ttgggtccag actgcgccac agcctctcgg gagacgtggg    120
 ccctcggaac ctttttagtg ccggactccg ggccgcaggc agtcccgcgg cagcaggatc    180
 acagaacctc tggatggact cttcctggga agctttgcta ctttgcagca gctggaccat    240
 gttcctcatt aacatctgtc tgtccgctta gtcatcacat catttcactg tggtggcagg    300
 gactcagctc ggaattctgt ataggaaaaa gcacctggat tcccagtctt ttcaatgggc    360
 ttcaaagaca accagaagtt gcctgctcct tgaaggctaa gttgcgccct ctaaggcaag    420
 aatgtcccct gcccatcggg attataccgc cggggcagtc agctatgatg ataccctcga    480
 ggaccctgcg cccatgactc ctcctccatc ggacatgggc agcgtccctt ggaagccagt    540
 gattccagag cgcaagtatc agcacctcgc caagtgtgga ggaaggagag gccagtctac    600
 cctcccctgc catgaccctg tcatcaagcc atttgacagt gtggacaagg ctcccaagtg    660
 ggtgaaggct aaagctaccc atgtcatcat gaattctctg atcacaaaac agacccagga    720
 aagcattcag cattttgagc gacaggcagg gctgagagat gctggctaca caccccacaa    780
 gggcctcacc acccgaggag accaagtacc tttcgagttg gccgaagcac tccacaaact    840
 aaagttacag agtggagagg ttaacaaaag aaggagaggc agcctgcatc agcccagtcc    900
 accccaagca ccactccgca ctcctttacc taagcagagg cccaggggct ggttcacttc    960
 tggttcttcc acaggcttac ctgggccaaa tcctagtatc atggactctg gaagttgggg   1020
 gattaaggac aagaaacttt gttcagataa gtggagcctc tttggaccga gatcccttca   1080
 gaagtacgat tctggaagtt ttgccaccca ggcctaccga ggagcccaga agccctctcc   1140
 attggaactg atacgtgccc aggccaaccg aatggctgaa gatccagcag ccttgaagcc   1200
 ccccaagatg gacatcccag tgatggaagg aaagaaacag ccaccacggg cccataacct   1260
 caaaccccgt gacctgaatg tgctcacacc cactggcttc tagagccctc tttccaggga   1320
 ttctggaaaa ggtggtttct tgcatcccac tcccctttta ccttggcttt gacataggaa   1380
 aggtatattt mamcmactta atcagctggg cgtscgtggc tcacgcctgt aatcccagca   1440
 ctttgggagg ccaaggtagg tggatacctg assgtcagga gttcaagacc agcctgggcc   1500
 aacatggtga aaccccgtct ctactaaaaa tacaaaaatt agctgggcgt ggtggtgggc   1560
 gcctgtagtc ccagctactt gggaggctga ggcaggagaa tcgcctgaac ccaggaagca   1620
 gatgttgtac cgagctgaga tcatgccatt acactccagc ctgggcgaca gaacgagacg   1680
 ccatcaataa ataaataaat aaagtaaagt aaaaaaccta ttaaattgag gctagagctg   1740
 gagatgtaat tggtttttga gaaacattag tataaagctt gcccttgttg tgtggaagaa   1800
 gccattttgt actgctttaa agttaggact aatattcttc aggcacgggt gtatggggac   1860
 ctcattacct atttttttca tcatttaccc tagggtaaga actttgatca ctgcttacta   1920
 ggtaaagaaa tgtttgtact gttccaaaac ccaagcttct ttattccttt accactatcc   1980
 atgtgagcat tgacaaatca tgggcttaga ggtgctcact gactcgctaa gacgactttg   2040
 gccctgttga tgactggtgc tgtgctccag cctttatcag ttaggggacc caaggtttgt   2100
 tttgggacct ggggtacagg taaaaagcca gactttgcag ggacccctct ttttagggtt   2160
 gaaccttgag tccccctgct tttttgggca gacctaatgg atcactgtct tgcagctagt   2220
 tcttcatgtg ggggcctctt aggccagttg cccggaggac ggcatgctcc tcctttctat   2280
 gccacaagaa caaacattat tttaggcaga gccttttttt gcatttaaag tgagattaat   2340
 ttagcctgta atttggttaa aaacttccta agagagaaaa ttaagtctac tgaattgggt   2400
 ataggtaaat ggacattaaa ccttttttaa aagtaaagga gatgggtagg ataccgttag   2460
 gattatagtc ttgaggttca tgtgaagccc agtgggtgtt aactttactt tggatttccc   2520
 ttgttcaggg tcaggggcct ggaacgcctg tgcggggaag gtcactccaa ttcaaaaatt   2580
 ttcctggtna tgaaagcaat ttttcaccaa aatgaggcct catccccttt atggcaacac   2640
 ataaccctta ctggagggag ggaaatacac gaagccacct ttttattttc tcttcactgt   2700
 gttacaagtt cacttggttg tcttgaacac tgtctccaaa tacctggctt tttgttttgg   2760
 atagtacctt gtctgtataa gaagctgggc ctttccatag agaggccctg gagtctaaaa   2820
 ttatgagaac aattaattta tttgtgtctt ctattatgat ctcgttttga caactcccaa   2880
 tccttactac tttttcaaaa aaaaaa                                        2906



      <210> 523
      <211> 4790
      <212> DNA
      <213> Homo sapiens


      <400> 523
 tcttgcggta ccgctccgga atttccgggt cgacgatttc gtgctgcatt gggcagagga     60
 agctgtgcaa cggggtcaac gactgtggtg acaacagcga cgaaagccca cagcagaatt    120
 gccggccccg gacgggtgag gagaactgca atgttaacaa cggtggctgt gcccagaagt    180
 gccagatggt gcggggggca gtgcagtgta cctgccacac aggctaccgg ctcacagagg    240
 atgggcacac gtgccaagat gtgaatgaat gtgccgagga ggggtattgc agccagggct    300
 gcaccaacag cgaaggggct ttccaatgct ggtgtgaaac aggctatgaa ctacggcccg    360
 accggcgcag ctgcaaggct ctggggccag agcctgtgct gctgttcgcc aatcgcatcg    420
 acatccggca ggtgctgcca caccgctctg agtacacact gctgcttaac aacctggaga    480
 atgccattgc ccttgatttc caccaccgcc gcgagcttgt cttctggtca gatgtcaccc    540
 tggaccggat cctccgtgcc aacctcaacg gcagcaacgt ggaggaggtt gtgtctactg    600
 ggctggagag cccagggggc ctggctgtgg attgggtcca tgacaaactc tactggaccg    660
 actcaggcac ctcgaggatt gaggtggcca atctggacgg ggcccaccgg aaggtgttgc    720
 tgtggcagaa cctggagaag ccccgggcca ttgccttgca tcccatggag ggtaccattt    780
 actggacaga ctggggcaac accccccgta ttgaggcctc cagcatggat ggctctggac    840
 gccgcatcat tgccgatacc catctcttct ggcccaatgg cctcaccatc gactatgccg    900
 ggcgccgtat gtactgggtg gatgctaagc accatgtcat cgagagggcc aatctggatg    960
 ggagtcaccg taaggctgtc attagccagg gcctcccgca tcccttcgcc atcacagtgt   1020
 ttgaagacag cctgtactgg acagactggc acaccaagag catcaatagc gctaacaaat   1080
 ttacggggaa gaaccaggaa atcattcgca acaaactcca cttccctatg gacatccaca   1140
 ccttgcaccc ccagcgccaa cctgcaggga aaaaccgctg tggggacaac aacggaggct   1200
 gcacgcacct gtgtctgccc agtggccaga actacacctg tgcctgcccc actggcttcc   1260
 gcaagatcag cagccacgcc tgtgcccaga gtcttgacaa gttcctgctt tttgcccgaa   1320
 ggatggacat ccgtcgaatc agctttgaca cagaggacct gtctgatgat gtcatcccac   1380
 tggctgacgt gcgcagtgct gtggcccttg actgggactc ccgggatgac cacgtgtact   1440
 ggacagatgt cagcactgat accatcagca gggccaagtg ggatggaaca ggacaggagg   1500
 tggtagtgga taccagtttg gagagcccag ctggcctggc cattgattgg gtcaccaaca   1560
 aactgtactg gacagatgca ggtacagacc ggattgaagt agccaacaca gatggcagca   1620
 tgagaacagt actcatctgg gagaaccttg atcgtcctcg ggacatcgtg gtggaaccca   1680
 tgggcgggta catgtattgg actgactggg gtgcgagccc caagattgaa cgagctggca   1740
 tggatgcctc aggccgccaa gtcattatct cttctaatct gacctggcct aatgggttag   1800
 ctattgatta tgggtcccag cgtctatact gggctgacgc cggcatgaag acaattgaat   1860
 ttgctggact ggatggcagt aagaggaagg tgctgattgg aagccagctc ccccacccat   1920
 ttgggctgac cctctatgga gagcgcatct attggactga ctggcagacc aagagcatac   1980
 agagcgctga ccggctgaca gggctggacc gggagactct gcaggagaac ctggaaaacc   2040
 taatggacat ccatgtcttc caccgccgcc ggcccccagt gtctacacca tgtgctatgg   2100
 agaatggcgg ctgtagccac ctgtgtctta ggtccccaaa tccaagcgga ttcagctgta   2160
 cctgccccac aggcatcaac ctgctgtctg atggcaagac ctgctcacca ggcatgaaca   2220
 gtttcctcat cttcgccagg aggatagaca ttcgcatggt ctccctggac atcccttatt   2280
 ttgctgatgt ggtggtacca atcaacatta ccatgaagaa caccattgcc gttggagtag   2340
 acccccagga aggaaaggtg tactggtctg acagcacact gcacaggatc agtcgtgcca   2400
 atctggatgg ctcacagcat gaggacatca tcaccacagg gctacagacc acagatgggc   2460
 tcgcggttga tgccattggc cggaaagtat actggacaga cacgggaaca aaccggattg   2520
 aagtgggcaa cctggacggg tccatgcgga aagtgttggt gtggcagaac cttgacagtc   2580
 cccgggccat cgtactgtac catgagatgg ggtttatgta ctggacagac tggggggaga   2640
 atgccaagtt agagcggtcc ggaatggatg gctcagaccg cgcggtgctc atcaacaaca   2700
 acctaggatg gcccaatgga ctgactgtgg acaaggccag ctcccaactg ctatgggccg   2760
 atgcccacac cgagcgaatt gaggctgctg acctgaatgg tgccaatcgg catacattgg   2820
 tgtcaccggt gcagcaccca tatggcctca ccctgctcga ctcctatatc tactggactg   2880
 actggcagac tcggagcatc caccgtgctg acaagggtac tggcagcaat gtcatcctcg   2940
 tgaggtccaa cctgccaggc ctcatggaca tgcaggctgt ggaccgggca cagccactag   3000
 gttttaacaa gtgcggctcg agaaatggcg gctgctccca cctctgcttg cctcggcctt   3060
 ctggcttctc ctgtgcctgc cccactggca tccagctgaa gggagatggg aagacctgtg   3120
 atccctctcc tgagacctac ctgctcttct ccagccgtgg ctccatccgg cgtatctcac   3180
 tggacaccag tgaccacacc gatgtgcatg tccctgttcc tgagctcaac aatgtcatct   3240
 ccctggacta tgacagcgtg gatggaaagg tctattacac agatgtgttc ctggatgtta   3300
 tcaggcgagc agacctgaac ggcagcaaca tggagacagt gatcgggcga gggctgaaga   3360
 ccactgacgg gctggcagtg gactgggtgg ccaggaacct gtactggaca gacacaggtc   3420
 gaaataccat tgaggcgtcc aggctggatg gttcctgccg caaagtactg atcaacaata   3480
 gcctggatga gccccgggcc attgctgttt tccccaggaa ggggtacctc ttctggacag   3540
 actggggcca cattgccaag atcgaacggg caaacttgga tggttctgag cggaaggtcc   3600
 tcatcaacac agacctgggt tggcccaatg gccttaccct ggactatgat acccgcagga   3660
 tctactgggt ggatgcgcat ctggaccgga tcgagagtgc tgacctcaat gggaaactgc   3720
 ggcaggtctt ggtcggccat gtgtcccacc cctttgccct cacacagcaa gacaggtgga   3780
 tctactggac agactggcag accaagtcaa tccagcgtgt tgacaaatac tcaggccgga   3840
 acaaggagac agtgctggca aatgtggaag gactcatgga tatcatcgtg gtttcccctc   3900
 agcggcagac agggaccaat gcctgtggtg tgaacaatgg tggctgcacc cacctctgct   3960
 ttgccagagc ctcggacttc gtatgtgcct gtcctgacga acctgatagc cagccctgct   4020
 cccttgtgcc tggcctggta ccaccagctc ctagggctac tggcatgagt gaaaagagcc   4080
 cagtgctacc caacacacca cctaccacct tgtattcttc aaccacccgg acccgcacgt   4140
 ctctggagga ggtggaagga agatgctctg aaagggatgc caggctgggc ctctgtgcac   4200
 gttccaatga cgctgttcct gctgctccag gggaaggact tcatatcagc tacgccattg   4260
 gtggactcct cagtattctg ctgattttgg tggtgattgc agctttgatg ctgtacagac   4320
 acaaaaaatc caagttcact gatcctggaa tggggaacct cacctacagc aacccctcct   4380
 accgaacatc cacacaggaa gtgaagattg aagcaatccc caaaccagcc atgtacaacc   4440
 agctgtgcta taagaaagag ggagggcctg accataacta caccaaggag aagatcaaga   4500
 tcgtagaggg aatctgcctc ctgtctgggg atgatgctga gtgggatgac ctcaagcaac   4560
 tgcgaagctc acgggggggc ctcctccggg atcatgtatg catgaagaca gacacggtgt   4620
 ccatccaggc cagctctggc tccctggatg acacagagat ggagcagctg ttacaggaag   4680
 agcagtctga gtgtagcagc gtccatactg cagccactcc agaaagacga ggctctctgc   4740
 cagacacggg ctggaaacat gaacgcaagc tctcctcaga gagccaggtc              4790



      <210> 524
      <211> 6829
      <212> DNA
      <213> Homo sapiens


      <400> 524
 ggaggcagag gggcggcgag aagatggcga cttcgaacaa tccgcggaaa ttcagcgaga     60
 agatcgcgct gcacaatcag aagcaggcgg aggagacggc ggccttcgag gaggtcatga    120
 aggacctgag cctgacgcgg gccgcgcggc tccagctcca gaaatcccag tacctgcaac    180
 tgggccccag ccgaggccag tactatggcg ggtccctgcc caacgtgaac cagatcggga    240
 gtggcaccat ggacctgccc ttccagccca gcggatttct gggggaggcc ctggcagcgg    300
 ctcctgtctc tctgaccccc ttccaatcct cgggcctgga caccagccgg accacccggc    360
 accatgggct ggtggacagg gtgtaccggg agcgtggccg gctcggctcc ccacaccgcc    420
 ggcccctgtc agtggacaaa cacggacggc aggccgacag ctgcccctat ggcaccatgt    480
 acctctcacc acccgcggac accagctgga gaaggaccaa ttctgactcc gccctgcacc    540
 agagcacaat gacgcccacg cagccagaat cctttagcag tgggtcccag gacgtgcacc    600
 agaaaagagt cttactgtta acagtcccag gaatggaaga gaccacatca gaggcagaca    660
 aaaacctttc caagcaagca tgggacacca agaagacggg gtccaggccc aagtcctgtg    720
 aggtccccgg aatcaacatc ttcccgtctg ccgaccagga aaacactaca gccctgatcc    780
 ccgccaccca caacacaggg gggtccctgc ccgacctgac caacatccac ttcccctccc    840
 cgctcccgac cccgctggac cccgaggagc ccaccttccc tgcactgagc agctccagca    900
 gcaccggcaa cctcgcggcc aacctgacgc acctgggcat cggtggcgcc ggccagggaa    960
 tgagcacacc tggctcctct ccacagcacc gcccagctgg cgtcagcccc ctgtccctga   1020
 gcacagaggc aaggcgtcag caggcatcgc ccaccctgtc tccgctgtca cccatcactc   1080
 aggctgtagc catggacgcc ctgtctctgg agcagcagct gccctacgcc ttcttcaccc   1140
 aggcgggctc ccagcagcca ccgccgcagc cccagccccc gccgcctcct ccacccgcgt   1200
 cccagcagcc accacccccg ccacccccac aggcgcccgt ccgcctgccc cctggtggcc   1260
 ccctgttgcc cagcgccagc ctgactcgtg ggccacagcc gcccccgctt gcagtcacgg   1320
 taccgtcctc tctcccccag tcccccccag agaaccctgg ccagccatcg atggggatcg   1380
 acatcgcctc ggcgccggct ctgcagcagt accgcactag cgccggctcc ccggccaacc   1440
 agtctcccac ctcgccagtc tccaatcaag gcttctcccc agggagctcc ccgcaacaca   1500
 cttccaccct gggcagcgtg tttggggacg cgtactatga gcagcagatg gcggccaggc   1560
 aggccaatgc tctgtcccac cagctggagc agttcaacat gatggagaac gccatcagct   1620
 ccagcagcct gtacagcccg ggctccacac tcaactactc gcaggcggcc atgatgggcc   1680
 tcacgggcag ccacgggagc ctgccggact cgcagcaact gggatacgcc agccacagtg   1740
 gcatccccaa catcatcctc acagtgacag gagagtcccc ccccagcctc tctaaagaac   1800
 tgaccagctc tctggccggg gtcggcgacg tcagcttcga ctccgacagc cagtttcccc   1860
 tggacgaact caagatcgac cccctgaccc tcgacggact gcacatgctc aacgaccccg   1920
 acatggttct ggccgaccca gccaccgagg acaccttccg gatggaccgc ctgtgagcgg   1980
 gcacgccggc accctgccgc tcagccgtcc cgacggcgcc tccccagccc ggggacggcc   2040
 gtgctccgtc cctcgccaac ggccgagctt gtgattctga gcttgcaatg ccgccaagcg   2100
 ccccccgcca gcccgccccc ggttgtccac ctcccgcgaa gcccaatcgc gaggccgcga   2160
 gccgggccgt ccacccaccc gcccgcccag ggctgggctg ggatcggagg ccgtgagcct   2220
 cccgcccctg cagaccctcc ctgcactggc tccctcgccc ccagccccgg ggcctgagcc   2280
 gtcccctgta agatgcggga agtgtcagct cccggcgtgg cgggcaggct cagggggagg   2340
 ggcgcgcatg gtccgccagg gctgtgggcc gtggcgcatt ttccgactgt ttgtccagct   2400
 ctcactgcct tccttggttc ccggtccccc agcccatccg ccatccccag cccgtggtca   2460
 ggtagagagt gagccccacg ccgccccagg gaggaggcgc cagagcgcgg ggcagacgca   2520
 aagtgaaata aacactattt tgacggctgt cttttatatt tctgagcaca cacagagccc   2580
 tggcgtccac cggggcaggc gcaaagtgga cagagcatgc agggcggcgg acccccccac   2640
 gaccctcctc gccctgtctc catcccctcg aagccctgcc tcaccgcagg caggcccatc   2700
 ggtggccacc tttgccggga agtgaccgga aggccccgtg aggggtcgaa cgcggaggca   2760
 ggggttacct cttggggctt tacaatccgt ggcccctcct gtcctgcact gtggtcaccg   2820
 gtcctgtcat agatgctgtt aatttaaggt acaggcagag gtggccaggg gagtttcatt   2880
 gtggtttttt tttcctttta gtttctagtt acattttggt tgtagatgac tcgcttaatc   2940
 ttttaagcca acacttgcct gagagcatgt ttttatttca gaaatccaac tttacctatt   3000
 ttttaagcta actggaaatg gaggccatgc gccccaaagc agcccgccac ccacctgagt   3060
 gtaagaagtg agtccggctt ttgggtttca ccccaagtta tctcaaaaca aaagggctgg   3120
 tcaggctggg cagggccttg tcaggagctc acggtaggca gaggtgcctc tgccagggcc   3180
 acagaacaga cttccgggaa ggggccttgg cttttattga gggtctctca aagacccagc   3240
 ctgccagcct ctcccagagg tgcctgctag tccttagagt gtgtgtgtga agatgccatg   3300
 accagtggca gctgagacct ctctgcccca agagtgtggg ggactggcag ggagcgaggg   3360
 tccccgagac gaggaccacg gtcctccctg agaacctggg tggaactggc atttcatccc   3420
 ctctccaccc taccctctgg ctcctagccc acaccccctc tcttgggcag cgtggtctgc   3480
 tggctgcccc ttcttggcag ctcagggtcg tggcaggtgg acttggagac acacagcagt   3540
 gtgtgtttta gtggcaggtt tcaggagcac ctctaagacc agggtgacag ggtacttggg   3600
 agctgtcctg gaccctcccc ataccacggg ccctgcaagg gaggcatcag ggctggcttt   3660
 gttttctgct gttcttggaa taggaactgc tgttctgatc cccccaaaac tgcattgcgg   3720
 ctctcgctcg ctcctgcctg ccgggacagc gccttctgct gagtccgttt atttgtagtg   3780
 tcatggctgc tgctttcact ggggtcctgg gcaccctggc ttctgtcctc agagctgggt   3840
 ttgatcctag caaccatccc ttcctctctt tgcccggcaa tgcctttggc atgtgtctga   3900
 gcagccaagt ggccactcat aggagaaggc tccctggtca cgttgctcct gctgccgtct   3960
 tgttccaagg tgcggggggg acactgttgg tctgtccagg tcaaggtccc tttctcttac   4020
 catgacagag gctgggggca gacagcgggg actttttttt ttttttaaga aaaactacat   4080
 gtacatagga gagtttcatt accattagac ttgtatgtag gacttaaaaa aaaatggcct   4140
 taataaaatt acaagcaacc cgcctggatg cggttttcaa aagaaggcat tgaggaccat   4200
 gctaggaaac ctcatacccc atccgtccaa cctccggcgg gcgccactgc ttgtcctctg   4260
 gtcttcggtg tggacagata ggagaggagg gatgcccacc tcggagcatc ccaggcccgt   4320
 ggcccatttt cagcatcctg aagccagatt cacagtgaca ttgtgttaac gtgacgacct   4380
 tggtccatta tggagttctt tttccaataa gaacctggtg gaccgaggtc cgagcttgcc   4440
 agggacagtg gggcccacgc gagtacccgg ggcccagcca ggagccagca gccaggcgtc   4500
 cctgtgttcc agaaggattc acgcccctcc tggacctggg cgggcctccc agggggtctg   4560
 tatcacggcc ttttgtgtgt gcgtacgtgt ggttttttta aatatcacta ctacatattc   4620
 ttgaattgcc aagactttct gaaacaagac agcttaaggg aatcagcctt ttgctttgtg   4680
 atgtgaaaat actgtgattt gacgagccgc ttcctgaggg gcaggcccac gtggggaggt   4740
 tgcgccgtgt acatagaccc gccgtctgtg tccttggtca ggcccggatg cttggtctac   4800
 actgggttag aggctgctct ccccacgcac ccatgtgctc atggcttctg cagaccctct   4860
 gctgggtaca tcggtcccct acggcgaagt tcagccaggg ctctccctcc tgagagcatg   4920
 gcgtccccac cttcctgttt cgccgacgtc actacccagg gttggcaagt cttgcaggca   4980
 gagggtgtaa cccaagttca gcctctctct gtgtccttca gagaagaagg gtttttttgc   5040
 cctcatcatt gtccctgctt gtgggttttc ggctctgggg aggagagtgt tgggatcatt   5100
 gtgtttggcc tgatttcttc agggggccaa gctcccggga ggacccctag ccagggaggg   5160
 ccccccatgt ccatccatcc ctcctgctgg ggcttggatg tcaggcttgg gggctgtgag   5220
 ctgggacctc gcctgagccc ggtcaggtgg gacaggagcc tgccagaagc ccatgggggg   5280
 ccagggccgg gtggctttct attttatttt tttagagatg gggtcttgct gtgttgccca   5340
 ggctggtctc ggactcctgg gctcaagcag tcctccctcc tcggcctccc aaagttctgg   5400
 ggctacaggt gtgagccact tctgcccagc atcccaggcc tgaacagcct tggcaggacc   5460
 cgtccctaga gggggctctg gtgcctccct taggtgggcc ttgagctggt ttttaaccaa   5520
 acatccttcc aaattcgggg ctgcgacctg gcttcctgag ttttctgtat ttccaaggag   5580
 ccctccgacc aggggagagg ctggtgggag taaaggtcca gcggtatttc gggggtcctc   5640
 tgtcacctcg ccctgaaaac agcagctccc atcaccttca ctgggtcccg atggagccgt   5700
 ctcagaggcc gaggggccct ctgtgtgggg gtgggacgca ggggctctca gagcaagggc   5760
 cacaaagccg atggcacaga tgtgcccctg ggcctggccc gtcacccaca tgtggtgccc   5820
 tgggccaggg cgtgcgggcg ccatagcctt ccctacacag cctaatagca ggggcgagac   5880
 tcggcccctc actcaccctg ggaggcctgc ctgggctaca tggacacctg ggtgtctttc   5940
 tacccccagt gcccatggac caggggcctc catttcctgg gggctcttgc ggcatgtgat   6000
 ttgggggtcc ctgggacatt ctcccgtcag ctccaccttg agccaagtgt cctgttccct   6060
 gcggcccttg gccttccagg gtcctggcca ggcaggggtc aggcacccca tactcttccg   6120
 tgtggcacag gtgtccaccc acccccactg gccacagaca ccattctccc cctgggagca   6180
 ggaggtggag taagttgtac ccccaggcct gggtgctggg gagttcctga gggcatgggt   6240
 ggggcaggag tgagtgcctc gtgatcccag cctcagtttc tctcttgtca ctttctcaaa   6300
 cctgcaggtc tcagggcccc gggctcctcc ctgggcagga tggggggcag gggctgggcc   6360
 ttggggtggt gctggctctg aatgattcca gagcctgtat ccaccttctg ggctccctgg   6420
 ccaagcaccc ccacccccag gagcccaggg aacaggtggc atgtgttggg gttcggggga   6480
 tggcccccat ctcgaagtgt tctggaattt tgggggcaac ccttgcccag cccaggccat   6540
 caagaacttc tgatttcctg cccacccagg aggggactta gccatggacc tttgccagta   6600
 ggcctgggga gggagggctt tggcagccaa agtctcaact ggccctgccg tgcccctgaa   6660
 gtaggaaact gtcccctagg gcctgggtgg cccacctgat atatgcaaac ccgccggtcc   6720
 gagccctgtt cctgcctgtg ctcctctgtg cccaggctgg ctctccccca accctagcat   6780
 gtatactctg ccacggacgt tcccgtgggc catgattgtg ggcggccgc               6829



      <210> 525
      <211> 382
      <212> DNA
      <213> Homo sapiens


      <400> 525
 ccggccgccc ccgtggggga cacctactct tcgacacagc tttaggaaac acctctacct     60
 cctgcgaggc ctcccgggct ccgggaaaac tacactggcc agacaattgc agcatgactt    120
 tcccagggcc ctgattttca gcacggatga ttttttcttc agggaagatg gcgcctatga    180
 gttcaatcct gacttcctgg aggaagctca tgaatggaac caaaaaagag catgaatagc    240
 aatgaggaat ggcatatccc ccattattat tgataatacc aacctccacg cctgggaaat    300
 gaagccctat gcagtcatgg cacttgaaaa taactatgag gttatattcc gagaacctga    360
 cactcgctgg aaattcaacg tt                                             382



      <210> 526
      <211> 404
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(404)
      <223> n = a,t,c or g


      <400> 526
 ggaattcccg ggtcgaccaa gcggctcaag atgtctggcg gggccagtgc cacaggccca     60
 aggagagggc ccccaggact ggaggacacc actagtaaga agaagcagaa ggatcgagca    120
 aaccaggaga gcaaggatgg agatcctagg annnnnnnnn nnnnnnnnnn nnnnnnnnnn    180
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    240
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnng ttctttcctt catcgtcagg gtcagcatcc    300
 actcctcaag aggagcagac caaagaggag ttgttgctcg attggaggca gagtgcagaa    360
 gaggtgattg tcaagcttcg tgtgggagta ggtcccctgc agcn                     404



      <210> 527
      <211> 389
      <212> DNA
      <213> Homo sapiens


      <400> 527
 ccaacagtag cagattaatg aggcattaat aggcttgtaa aaattggggt aagtgggaag     60
 ctactgtgta tttggcctaa catggttttt aaatgctgac aatagagtta tctattttta    120
 aatacattgc tttcattttt ggctgcatga atatcctatt ttcttctttt agaaaagata    180
 ttactgcatt aacaatatca cttttaggtt ttgttttttc ttgtcttaaa atagtcaaat    240
 tgtagctttt tcacttgctg tgtgcgcttt caagattttt ttttacccgt tttcttctct    300
 gcagcagtct cctgggttag gcaggcctat ctggctccag attgccgagt ctgcttacag    360
 attcactctg ggctcagttg ctggagggg                                      389



      <210> 528
      <211> 433
      <212> DNA
      <213> Homo sapiens


      <400> 528
 caaggagttc gtgactgctg tggttctggg caaagacctc gtccccagga ttggcctctc     60
 tcagctggaa ggcttccgca gacagctcct ggatgtcctg cagcgaagca ccaagcccaa    120
 atggcggatc atcgtggggg ccaccaaatg catccccaag tcggagctgc ctgaggaggt    180
 agaggtgacc accctggcca gcacgcggct ctggacccac cccagcgacc taactatagc    240
 cctctcagcc agcactccac tctacccgcc cggccgcatc atccacgtgg tccacaacca    300
 ccctgcagag cagtgctgct gctgtgagca ggaggagccc acatcctttg ccatctgggg    360
 cgacaacaag gccaacaatg aggtgatcat ctcgccagcc tgtattgcgg ccgctcggag    420
 gatcaagcta cga                                                       433



      <210> 529
      <211> 438
      <212> DNA
      <213> Homo sapiens


      <400> 529
 cattcgggag gtgcagaaac tggtggagag cggggtggat gtgaactccc aaaatgaggt     60
 caacggctgg acttgtttac actgggcatg taaacgaaac catggtcagg tggtctctta    120
 cctgttaaaa tcaggagctg acaaagaaat tcttaccaca aaaggagaaa tgccagtcca    180
 gttaacatca aggagagaaa tcaggaagat tatgggagtg gaagaagaag atgatgatga    240
 tgatgatgat gacaacctcc cccagctgaa gaaggagtca gaactgccct ttgttcccaa    300
 ctatttggcc aacccagcct tcccttttat ctatacaccc acagcagagg attcagccca    360
 gatgcagaat gggggcccct ccacaccccc tgcatcaccc cctgcagatg gcgaagcggc    420
 cgctctgagg atcacgca                                                  438



      <210> 530
      <211> 398
      <212> DNA
      <213> Homo sapiens


      <400> 530
 acccctccag tgccaccgtc tgcagcttca tcgagcagca gtttgtccag cagaagggcc     60
 aacgttttgg gcttgggagc ctggcccaca gcatcccctt gggccaggca gacccctcgc    120
 tggcccctta cattattgac ctccccagct ggacccagtt ccgccaggac accggcacca    180
 tgcgggctgt gcggagacac ctgttccccc agcactcagc ccctggccga ggtgtcgtct    240
 gggagtggct gagcgacgat ggctcctgga ctgcctatga agccagcgtc tgtgactatc    300
 tggagcagca ggtggccagg ggcaaccagc tcgtggactt ggcccccctg gggtacaact    360
 acactgtcaa ctacaccacc cacacgcaga cctgtatt                            398



      <210> 531
      <211> 433
      <212> DNA
      <213> Homo sapiens


      <400> 531
 gcacgctacg tacgcttgga tgctctatat cggccgcgcg ggctgccagg gtatttcggg     60
 aagggggcgt gaggaggcgg cggcggcagc ggcgggtagg gctggcagca tagggaagga    120
 gaaagaaagg taggaagagg gcggggagtc ctcagaggag gaggcgggac cggccgggca    180
 cctcacctgt ctgatgcctg tgtacacatt ggtgttcttg gagccctttt gcagtcatca    240
 gcatctatgg atgcgcatcc cgccacagca gacaatcatg gatatacggc acttcactgg    300
 gcttgctaca atggtcacga gacatgtgta gaactgcttt tagaacagga agttttccag    360
 aaaacggatg gatatgcttt tagtccattg cattgtgccg tgataaatga caacgattgt    420
 gctgctgata tgt                                                       433



      <210> 532
      <211> 395
      <212> DNA
      <213> Homo sapiens


      <400> 532
 ggtgatcgca gaaaatcagg gcaagattaa gacgtacatc agtcaagtgt gtgatgactc     60
 catggtctgt cgcttggact cagctgtgca tatggctggg ctaagactgt taaccaacat    120
 gactgtgact aatcattgcc aacatttgct ttcctattct tttccagact tttctgcttt    180
 gttattcctg ggaaatcact tcaccaagat acagattatg aaactaatta taaactttac    240
 cgaaaatcca gccatgacaa gagagctggt cagttgtaaa gtaccatcag aattgatttc    300
 cctctttaat aaagaatggg atagagagat tcctcctaat atccttaccc tatttgagaa    360
 tataaatgac gacataaata atgaagggca tgtat                               395



      <210> 533
      <211> 430
      <212> DNA
      <213> Homo sapiens


      <400> 533
 cttgacctga tacgcctgct tggccgaggg actgacaagc gatccaagtt caagaagctg     60
 atgaagcagg gtgtggcggc tctggagggt agtgcgttgg ccaacgggcg ggccctgtct    120
 gctggctccc cacccgtgcc gcccggctgg aaccctaact cttcatccgg gaagggctca    180
 tgaggaaacg cgggctccta tatccccagc tacacatcgg ggtacccttc agcgcaccaa    240
 gaagctatgc agcaacccca acttatgtga ggctgcccgc ccgtctgctt cttgcctccc    300
 cggcccaggt ccctcccgcc tccaggtcca tccatcccgt ccggaaaaga aggacccaaa    360
 gggaagatgg aacagtggag gcgggacgcc ctccatctcc tcggagcccc gcgaggtccg    420
 gcccagcaac                                                           430



      <210> 534
      <211> 1659
      <212> DNA
      <213> Homo sapiens


      <400> 534
 ggacttcgga cgaggcctgg ccgagcgctt cctcacagcg ggcaggacgg accccgccca     60
 cgacgtgcgg gtggcggtgg tgcagtacag cggcacgggc cagcagcgcc cagagcgggc    120
 atcgctgcag ttcctgcaga actacacggc cctggccagt gccgtcgatg ccatggactt    180
 tatcaacgac gccaccgacg tcaacgatgc cctgggctat gtgacccgct tctaccgcga    240
 ggcctcgtct ggcgctgcca agaagaggct gctgctcttc tcagatggca actcgcaggg    300
 cgccacgccc gctgccatcg agaaggccgt gcaggaagcc caacgggcag gcatcgagat    360
 cttcgtggtg gtcgtgggcc gccaggtgaa tgagccccac atccgcgtcc tggtcaccgg    420
 caagacggcc gagtacgacg tggcctacgg cgagagccac ctagtccgtg tccccagcta    480
 ccaggccctg cttcgcggag tcttccacca gacagtctcc aggaaggtgg cgctgggcta    540
 gcccaccctg cacgccggca ccaaaccctg tcctcccacc cctccccact catcactaaa    600
 cagagtaaaa tgtgatgcga attttcccga ccaacctgat tcgctagatt ttttttaaag    660
 ggaaagcttt aaaagccagg acacaatgct gctgcctgct ttgtgcaggg tcctccgggg    720
 ctcagccctg agttggcatc acctgcgcag ggccctctgg ggctcagccc tgagctagtg    780
 tcacctgcac agggccctct gaggctcagc cctgagctgg cgtaacctgt gcagggccct    840
 ctggggctca tccctgagct ggcctcacct gggatcccca ccccgggctc tcctgccctg    900
 ccctcctgcc cgccctccct cctgcctgcg cagctccttc cctaggcacc tctgtgctgc    960
 atcccaccag cctgagcaag acgccctctc ggggcctgtg ccgcactagc ctccctctcc   1020
 tctgtcccca tagctggttt ttcccaccaa tcctcaccta acagttactt tacaattaaa   1080
 ctcaaagcaa gctcttctcc tcagcttggg gcagccattg gcctctgtct cgttttggga   1140
 aaccaaggtc aggaggccgt tgcagacata aatctcggcg actcggcccc gtctccctga   1200
 gggtcctgct ggtgaccggc ctggaccttg gccctacagc ccttgaggcc gctgctgacc   1260
 agcactgacc ccgacctcag agagtactcg caggggcgct ggctgcactc aagaccctcg   1320
 agattaacgg tgctaacccc gtctgctcct ccctcccgca gagactgggg cctggactgg   1380
 acatgagagc cccttggtgc cacagagggc tgtgtcttac tagaaacaac gcaaacctct   1440
 ccttcctcag aatagtgatg tgttcgacgt tttatcaaag gccccctttc tatgttcatg   1500
 ttagttttgc tccttctgtg tttttttctg aaccatatcc atgatgctga cttttccaaa   1560
 gaaaggtttt cactcctccc ggaagggggc agtgccattt ccaaggggga ctcctctcgg   1620
 ggctcccgcc cgcgttgtcc tcgcgcccga accccgacg                          1659



      <210> 535
      <211> 1572
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1572)
      <223> n = a,t,c or g


      <400> 535
 agttggatcc tttagaacgg ccgccccnnn nnnnnnnnnn naagagtttc tagagttttt     60
 attattcaaa atgagtttca tttcaattca ggtacttgaa agaaggttct agtctgttac    120
 tttgacacag cacaagatca atagtttatt ctgatgaagt attccaccca aatgaaagca    180
 taacatgcaa gtagtcattt atttcaatca ctcctatttg aaggtcctta tttttggaga    240
 acagtcaggc attttattat ccactctttc cattccttaa aggcttcctt ccacgggttt    300
 cagtaaattc ccattatcct cacgactgtg ttctggagtt gctccaggtg tgccagaaga    360
 ttcatcatca atccacctca ccagtgccat ctgtcaaaga ggcctgtcca aagacaaaat    420
 tccacaagtc tcttgggtaa agatcaatca ttgttattcc cacaacacag aaggcatctt    480
 caggtttctt ctttttcaag aacttcagga tgtcccctgc atgaatttgt aggttttgtg    540
 tgttctcatt gactctaaag gaacaccttg ttgtagaaac aggaactggt tctagcagtt    600
 ttactctcaa gcgatagaaa tatgctttac agtagcccgt gagccattta atatattctt    660
 cactgataat tctggtgctt catagagatc caatggaccg tatataaata ctgcgtttgt    720
 ctggagaggg tatctttctg taaggatgac tgaagaactg ttcaaagtct tggggggcct    780
 cagggtggga ggtgatccaa tctgatggag aatgcaaggt ccaaagagat cactggctgg    840
 ctggaatgct tcattcatta aacgctgttc cccagcatct actttctcat actgtgacac    900
 aagcactgga ttctttgaga tgacagctat ttttagtgtc tgttcggaat accgtactat    960
 ttgcatcttg attaggaagg aaggctccca tggaagcttt tatctcacaa ggacagacat   1020
 gtctgggcct ggccagaagg aagttgtgga gtgtgccttc atctttatat taacgaaggc   1080
 agtgagaaaa gtcaggaggc ctccccttgc ctcccaagcc taatctaggg aagctgcggg   1140
 agaagatggg cagggggcgc acaatatggt cactgtggtg ggctggaggc ctgggacgct   1200
 gtggtcccaa aaccagaaca tctcgggcca accgggagaa gttggccacc ctagctggtt   1260
 gcctacagca actcgcactg tgggctctgg tccgtgcagg cacaacccag gctccggctg   1320
 ggggtggagt agggcttccc cggggactct cgcttcgcct cttcttcccc caggagcctc   1380
 tggaaaggcc tccctggctc cccagaggca ctccgccccc gcagtccccg cggcttccgc   1440
 cacgtccgtc cctcctacat cctcatccct ctccaccgac cgcgactggc gcccgcctct   1500
 acgacccggc tgccccgccc agctctgaca gcacctgcga accgccctga cccaacaggc   1560
 ctcgacacga aa                                                       1572



      <210> 536
      <211> 400
      <212> DNA
      <213> Homo sapiens


      <400> 536
 cccacagcca acattatcac tagtggtaac agggaaaatg tcccctttga ccccaacccc     60
 aagtacagaa catgcaagga cgcctgttct cactgcatgt cttctgtgtt gtactgaagc    120
 tcctagctgg tgcagtgagg caagacaaag aaaggaaata taggtgcact gggaaggaag    180
 aagaaacact gcctttattc tttaggtgac atgattgtgt gcttttaaaa taataaagga    240
 atcaacagaa aagttgctta acctaatgaa tgagtttatc aaagtcacaa gatacaaggt    300
 cagtatacaa aaatcagttg gatttctaca tggtagaaac aactgtacat ggaaaaatgt    360
 ttaatagtgt aagatatgta cattggaaac tatgaaagag                          400



      <210> 537
      <211> 1273
      <212> DNA
      <213> Homo sapiens


      <400> 537
 ttttttttag gttttaccat tcgggattat tcttagcaga tgctgcagat aacgtggaga     60
 gcatatgaaa gacacatgtt tgaaccaata gtgacataca ggtgctaagt tctgcagtag    120
 gggaagggca gagagccatg gagaaggcct ggcccaatcc tggagcctca gaaaaaaagt    180
 tccttattaa attgctgttt tagctaagac ttgtgggatc ggtagtagtt ggagatccca    240
 gagaggatgt gaccgagtca gccagggaaa aatttggtcc tggcacccat ggcagagttg    300
 agtgatccag tccttctgtc tcctctggct ggaagtccac caaatctggg gaatgtccag    360
 tgggggaagg ggggctgaca atgatcatag aaccttcacc tgtcctcaca tgttcctctg    420
 tgtattctgc aaagcctctg cctcagtctc ctcttttgga aagtgggatt ggaaaccaac    480
 atctgcttct ctcccaggac tgctctctga gcttctgtga ccttgtaaaa taggctgcat    540
 tgcaccaaac atgcaggagg aatcccagca tcctcctgtg cacaaggctg gtttcttccc    600
 atccttttcc ttgttctgcc tctctcctcc tctccaagag ataaatacat gtggacccag    660
 caggggccta tgtttgcaaa agctctcagg tgattctcat gcagccagcc tggctctggc    720
 actgagttct ttgacacttc tgggggcgca tttactattg aggaaggtca ctgtgtgctg    780
 aaaggcatga ctcatcttcc attcctttct tccatgaagc aaggcgcatg ggtcgactga    840
 gctgggagag tccacagtgt cagcctcccc cacgcttccc tccctcctta ttccttgtgt    900
 gctgtacttt gtcttgattt cctgtactct cagcagatag ctgtgatcca ctgcaaagga    960
 catcaaaaag aaaacacagc cattgcccat agtagccaga aagctgattc agcagctcag   1020
 gtctcagcga gactttcagt cacgcctgta aacttgaagc ctacagtctc ctttccacag   1080
 ccagatctgc ctgacaatcc cgtatactca acaacaacag aaaaactggc ttcagatctc   1140
 agagccaata aaaatcagga aagttagtag attcttcctg actctggaat cttcataccc   1200
 tgaacttaaa ccagttacct acagtctacc acccatttaa gaagagcaaa gttacctcag   1260
 ctcctccgga ggg                                                      1273



      <210> 538
      <211> 1027
      <212> DNA
      <213> Homo sapiens


      <400> 538
 tgaacacggc acgcaatcca aagaggcctt cgccatcggt gagagcagcg ggggggtggg     60
 acctgctgcc ggacgcctgc ctccggctcc cctccagtgc ctgtggagca ggagaaggaa    120
 gccgggcaac cgcaggcagc ggcagcggga tgggcacctc tgggacctat ctgtgccggc    180
 agcctgcctg ttcctcacag agggtctcca ctcccgccgg caggcttggg agggcggcag    240
 tgcctctggg aagaccactg tggccagaat gatcatcgag gccctggatg tgccctgggg    300
 tgggtctagc ctgccatgga ctccttctac aaggtgggcc cccgcccagc tcccccgagg    360
 acccctttgt cctctccctg accctggacc ccctgcaaaa gtaggtccct ggtctcagcc    420
 ccagcgtggc tgctcctggg aggcctagag cccctgtccg ctggcattgg gtgagggccc    480
 tactgtgccc acagctgttc cacagcctcc cccaccaggt gctgactgag cagcaacagg    540
 aacaggccgc acacaacaac ttcaacttcg accacccaga tgcctttgac ttcgacctca    600
 tcatttccac cctcaagaag cttgaagcag gggaagagtg tcaaggtgcc catttatgac    660
 ttcaccacgc acagccggaa gaaggactgg aaaacactgt atggtgcaaa cgtcatcatc    720
 tttgagggca tcatggcctt tgctgacaag acactgttct gagctcctgg gacatgaaga    780
 tctttgtggg acacagactc cgacatccgc ctgggttacg gcggctgcgc cgggacatca    840
 gtgagcgcgg ccgggacatc cgagggtgtc atcaagcagt acaacaagtt tgtcaagccc    900
 tccttcgacc agtacatcca gcccaccatg cagcctggca gacatcgtgg tcctcagagg    960
 gagcggcaac acggtgggcc atcgaccttg attgttgcag cacgtgcaca gccagctgga   1020
 ggagcgt                                                             1027



      <210> 539
      <211> 1735
      <212> DNA
      <213> Homo sapiens


      <400> 539
 tttttttttt ccttggtgga aatttttttg gtgttttttg tgctctgttg caagctgatt     60
 cctagattaa tggcctccca gcagatttga aaggaaacct ggaagacttc ttattttgct    120
 gtgccttctg cttcctggtc ttgtgtaaag tcccaattca ctctcaattt gatccagctc    180
 tgactggtca agtagttcaa aagtcatcac cttcttcagt gtctgtgtcc tcttctggga    240
 tgggggcagc ctgagaaagt gcttgctgca caccctctaa ctggtctttg atagctgcaa    300
 gtcactgcag cttgtggata acatccccag ccagggtttg cttcatcagg tgaaaaggtt    360
 ttgggtcact ggttcagagg aaaggggtga gacccagctg ctggattgcg tcttctttgc    420
 ttgggtcttg tgaccactgt ccaacttgtt ccttctttct cttgagctca gtggggcaaa    480
 ccaagggtta aatttcatct tcatcatttg gttcccatgc catttttcta gagatggaaa    540
 atctgaaaga tctctagaga aaacttcctc actgggtcgg tcaagatcat cagaagtgtc    600
 tgtctgtgga gtgtatcctt ctgaaaggtt gaaggtccca ttatcagtcc aggatacctc    660
 tgagacgtct gtgtcagaca cagataactc tttggcagca accgtgaggc taatcttagg    720
 acaaagagct gaaaagtcta attcactgtc atctttgtga cttttttctt tgtctgcttc    780
 agatctctca cgtttcttct gattaatata ttctccaatt ccaaaatcca gtttcagcag    840
 aactgactta attttgctgt aaattttttg tccaatatca ttacatttaa acaatggaca    900
 caaaaatgca acacagtaaa cagtagatag ctgagtataa cccccaggaa tggtaacttc    960
 cccaagatcg taaaaaaatg tgcaacaaca cttacaagac ccaggaagac aaaaacttgc   1020
 ccagggctct gctgtttaaa aagagacatt tcttgaagaa atatgctgaa attcatccat   1080
 gattctgcaa taccagtggc tgagccctgg gtctttcatc tggtttggaa ttgataactt   1140
 cccagccttt cactgaggct tctccacaac tgtgcacctc ttgttctaga caaaaccata   1200
 tcctttatta tttgcataat aacacgccca agtatcatga cggaaatcag gtgatatact   1260
 ctccatggag tcaatgcaag gaaccagaac agcaggttgg cagcgacgaa gccgagcagc   1320
 gtccgcagcg gcctcttcca gctcagcagc tcgtcggcgc ggcagcccag ccacagcgac   1380
 cggctccccg agcagccagg ttaccgcggc cgccgcccgg cccgcggcct cctccacctg   1440
 caaccccgcg ccctccgccg ccccagcttc ctgcgcttcc tcctcctgct gctgccgctc   1500
 tgcgggggat gcctggggcg gtggcggcga cggcggcgcc tgctcctcgg cggcaggagc   1560
 cgggcatccc tcctcggcgt gctccggagg cgccgggctc gccatcttca gctgtgcttc   1620
 caggcaggga cggggccggg cgcgcgcgcg ggcgcgcctg ggtgtgggtg ccgccgaggg   1680
 cggggcggcg gtggcggcag gtcccggagc ggggcgcgca ccgcggggca caggc        1735



      <210> 540
      <211> 459
      <212> DNA
      <213> Homo sapiens


      <400> 540
 tgatacgtcg tacgctgcca cgccatcctg gccgagggcc tgggagaact tctccatcaa     60
 gatgttcctg acagtgacac ggttgtactt catcgccgag gaggggggtg agcgctctgt    120
 ctgcctcacc tttgccttcc tcttcctgct gctggccatg ctggtgcaag tggtgcggga    180
 ggagaccctc gagctgggcc tggagcctgg tctggccagc atgacccaaa acttaaagcc    240
 acttctgaag aagcagggct gggactgggc gtgagtcctg ggaatggggg agggaggcaa    300
 gggcaggctg ggaccctccc agggtccccc aggcaggctc gtgacctggt ggtctcctaa    360
 gcttcctgtg gccaagctgg ctatccgcgt gggactggca gtggtgggct ctgagctggg    420
 tgccttcctt accttcccaa gcctgtgggt ggtccacac                           459



      <210> 541
      <211> 507
      <212> DNA
      <213> Homo sapiens


      <400> 541
 gaaggaggtc ccccacgggc ccttcaggac tgaaagctgc ggtgctgacc ttggccggtg     60
 ctcttcctga cggggagcca ggctcggcat ttctggcagc aagatgaacc cccccagagc    120
 ccctgggatc gagtgaagga cctggccact gtgtacgtgg atgtgctcaa agacagcggc    180
 aaagacagcg tgacctccac cttcagcaag ctgcgcgaac agctcggccc tgtgacccag    240
 ggagttctgg gataacctgg gaaaaggaga cagagggcct gaggcaggaa gatgagcaag    300
 gatctgggag gaggtgaagg ccaaggtgca gcccttacct gggacgattt ccagaagaag    360
 tggcaggagg agatggagct ctaccgccag aaggtggagc cgctgcgcgc agagctccaa    420
 gagggcgcgc gccagaagct gcacgagctg caagagaagc tgagcccact gggcgaggaa    480
 gatgcggacc acgccgcgcc catgtgg                                        507



      <210> 542
      <211> 909
      <212> DNA
      <213> Homo sapiens


      <400> 542
 ggaattcccg ggtcgacgat ttcgtggatg aaaggaggga acgcagacag ctggcagaga     60
 tagatatttg gctagcatgg aatcaccaga ggagcctgga gcatccatgg atgagaacta    120
 ctttgtgaac tacactttca aagatcggtc acattcaggc cgtgtggctc aaggcatcat    180
 gaaactgtgt ctagaggagg agctctttgc tgatgtcacc atttcggtgg aaggccggga    240
 gtttcagctc catcggctgg tcctctcagc tcagaagctg cttctttccg atccatgttt    300
 cacttccaac ctgaaaggag gcccacaacc ggggtgattg tgcttgcaag gatttcagcg    360
 agtctgtttt ccagctcctg gttgattata tctaccatgg gactgtgaaa cttcgagctg    420
 aggagttgca ggaaatttat gaggtgtcag acatgcattc agctgacatc tctttttgag    480
 gaatgctttc ggtttttggc ccgcacagtg caagcgggaa actgccttca ggtgatgtgg    540
 ctggcagatc ggcacagtga tcatgagctc tatacggctg ccaagcactg tgccaagacc    600
 cacctggccc agctgcagaa tacagaggaa tttctccact tgccccgccg cttactcaca    660
 catatcatct cgggtaagtt tagggagggg acacaccata cccagttact tggctatgat    720
 gttcagtgaa tgttctagtt taggagaaaa gaaccctcaa gcttcctggt gttagtttac    780
 attattattc ctgcattctt cctgagatat cctgctgaga aagattgagg tgagattcag    840
 tgtaattgct gtcagagact gtattgcgtc cgctctagag gatcaagctt cggcgcgtca    900
 tacgcatgc                                                            909



      <210> 543
      <211> 406
      <212> DNA
      <213> Homo sapiens


      <400> 543
 catccgcttg aacaccaaag aagacaaaaa tggtgtcccc gacttagtgg ccctgctggc     60
 tgtgagagac accccggacg aggagccggt ggacagcgac acttcggaga gcgactcgca    120
 ggaaagtggg gaccaagaaa cagaggagtt ggataatcct gagttcgtgg ccattgtggc    180
 ctataccgac ccgtcggacc cctgggcccg ggaggagatg ttgaaaatcg cttctgttat    240
 cgagtcgctg ggctggagcg acgagaaaga caagcgagac cccctccgac aggttcttgt    300
 ccgtcatgtc caaggacact aacgggaccc gcgttgaagg tgggaagagg cgggccgcga    360
 aggttgggac gccgtggttc ctgcgcaagg ccggggattg acgggg                   406



      <210> 544
      <211> 774
      <212> DNA
      <213> Homo sapiens


      <400> 544
 gatacagttc tgaccatcat tacgccaatc ttggcacgag gggaagatgg cggagtccgg     60
 cggtagcagc ggtggtgctg gtggcggcgg cgctttcggc gcgggcccgg gccccgagcg    120
 cccgaacagc acggccgaca agaacggggc cctcaagtgc accttctcgg cacccagcca    180
 cagcaccagc ctcctgcagg gcctggccac cctccgcgct catgggccag ctcctcgatg    240
 ttgtgctgac tattaacaga gaggcctttc ctgcacacaa ggtcgtcctg gctgcctgca    300
 gcgactactt cagggccatg ttcaccggcg gcatgcggga ggcaagccag gacgtcatcg    360
 agctgaaggg cgtgtcggcc agtggcatgc ggcacatcat cgacttcgcc tacagcgccg    420
 aggtgacact ggacctggac tgcgtgcagg acgtgctggg cgcggccagt gttcttgcag    480
 atgctgcccg tggtggagct gtgcgaggag ttcctgaagg cggccatgag cgtggagacc    540
 tgcctcaaca tcggccagat ggccaccacc ttcagcctgg cctcgctgcg agagtcggtg    600
 gatgccttca ccttccggca cttcctgcag atcgccgagg aggaggattt cctgcgcctg    660
 ccactggagc gcctggtctt cttcctgcag agcaaccggc tgcagagctg tgccgagatc    720
 gacctgttcc gcgcggccgt ccgctggctg cagcatgacc cggcccggcg gccg          774



      <210> 545
      <211> 960
      <212> DNA
      <213> Homo sapiens


      <400> 545
 ttctggaaat aagctattta ttaccgtctt cctttatcca tctgccattc acatctcatt     60
 ccaacaacat tcaaaatctt aaacaacctc tcccaagggt ccacgatctg ggatgatgtt    120
 tccgtcagcc cctctattat gtacctctga gagctacgtg tgctaggtga cattaaatgc    180
 agatgtatcc tgggcgccgt gatgctgatg tctctatttg agtagaccta gtgacataat    240
 tgatatagaa ttcagctgct ttgttcaagt acttatacaa taaattggca ggtaatcgaa    300
 catcatgagt tgttaattat tagaggaagg acatcacaaa caaataattt tctaaagcag    360
 ttcactggag attcttgttc ttcaatagtt tcagcctcta atagtgcctc cccaaggcca    420
 accccatgct gcaccaccgt ttcagggaag cgcctcaaaa gtagaagcaa catttctgat    480
 cgttctaacg tgttgaagca ttgttccgtg acctttagta acatttcaca ctggacccga    540
 ccaggaagag tttcaaataa acttcttaaa aattgggttt gtttgtcctg tgaatcgttc    600
 cttaatgctg atgtaataat gctgatttct ctccacacca ccggctggtc tgggaaattc    660
 acaaacatgt cgtacagcag cctcccggcg gtggcggtcc gctctgcatt ccgctcgatg    720
 gtgtacatct catactggat gttaaagtct gccgggtaga ggctgcgggc cgtgatcagc    780
 cacgccttgg ctgcccacag gtcttgcggc accaactccc gggctcgctg caccaggaac    840
 tcgcagtccc cctgggcaga catgacccga gcgctctcca gccgccagcc cgaagcggcc    900
 ggaacgtccg gctcaggact ctcagccgcc acggcagcca ccgccgccgc cgccacgaaa    960



      <210> 546
      <211> 960
      <212> DNA
      <213> Homo sapiens


      <400> 546
 ttctggaaat aagctattta ttaccgtctt cctttatcca tctgccattc acatctcatt     60
 ccaacaacat tcaaaatctt aaacaacctc tcccaagggt ccacgatctg ggatgatgtt    120
 tccgtcagcc cctctattat gtacctctga gagctacgtg tgctaggtga cattaaatgc    180
 agatgtatcc tgggcgccgt gatgctgatg tctctatttg agtagaccta gtgacataat    240
 tgatatagaa ttcagctgct ttgttcaagt acttatacaa taaattggca ggtaatcgaa    300
 catcatgagt tgttaattat tagaggaagg acatcacaaa caaataattt tctaaagcag    360
 ttcactggag attcttgttc ttcaatagtt tcagcctcta atagtgcctc cccaaggcca    420
 accccatgct gcaccaccgt ttcagggaag cgcctcaaaa gtagaagcaa catttctgat    480
 cgttctaacg tgttgaagca ttgttccgtg acctttagta acatttcaca ctggacccga    540
 ccaggaagag tttcaaataa acttcttaaa aattgggttt gtttgtcctg tgaatcgttc    600
 cttaatgctg atgtaataat gctgatttct ctccacacca ccggctggtc tgggaaattc    660
 acaaacatgt cgtacagcag cctcccggcg gtggcggtcc gctctgcatt ccgctcgatg    720
 gtgtacatct catactggat gttaaagtct gccgggtaga ggctgcgggc cgtgatcagc    780
 cacgccttgg ctgcccacag gtcttgcggc accaactccc gggctcgctg caccaggaac    840
 tcgcagtccc cctgggcaga catgacccga gcgctctcca gccgccagcc cgaagcggcc    900
 ggaacgtccg gctcaggact ctcagccgcc acggcagcca ccgccgccgc cgccacgaaa    960



      <210> 547
      <211> 450
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(450)
      <223> n = a,t,c or g


      <400> 547
 gcggtattcc gacgagtaga ttccacgagc agcagcctgt ggcacccgct gggcgcgggc     60
 agcagggaag agggagcaag gcattgtcca cagactgctg gggtcacttc tttgcccacg    120
 ggctccctgc tcccccagtt ttttttctct ctttgttaac aaatgtgtct gagtcttgga    180
 aaacacccca accccggaaa tgtgtgggaa aaagaaaaca aaaactttcc nnnnnnnnnn    240
 nnnnnnnctc ctttttaagt tttataaaac cctcccccct cggggggggc cccgacccca    300
 attccccctt aaggggggca gtataaaatt caacggccct gcgtttaaaa aggtggggac    360
 tggaaaaacc tgggctgccc caaattaatt tgcttttggc gaanattttn ttngtatgga    420
 taataatgca gccactatta catgcctcag                                     450



      <210> 548
      <211> 451
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(451)
      <223> n = a,t,c or g


      <400> 548
 gtgcactttt gntttgggcc ctacaactgc accctgagcc ggagctgccc agtcgccgcg     60
 ggaccgtggt ttctggggtc tggacggggg tcgccatgat ccgctttatc ctcatccaga    120
 accgggcagg caagacgcgc ctggccaagt ggtacatgca gtttgatgat gatgagaaac    180
 agaagctgat cgaggaggtg catgccgtgg tcaccgtccg agacgccaaa cacaccaact    240
 ttgtggnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    300
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnntcc    360
 ggaactttaa gatcatttac cgccgctatg ctggcctcta cttctgcatc tgtgtggatg    420
 tcaatgacaa caacctggct tacctggagg c                                   451



      <210> 549
      <211> 473
      <212> DNA
      <213> Homo sapiens


      <400> 549
 gtcccggatc gacccacgcg tccgccacgc gtgcgcccac gcgtccgcat tttgtgagcg     60
 ctggtggcgg agttaaagtc aaagcaggag agtaattatg aatagcgcag cgggattctc    120
 acacctagac cgtcgcgagc gggttctcaa gttaggggag agtttcgaga agcagccgcg    180
 ctgcgccttc cacactgtgc gctatgactt caaacctgct tctattgaca cttcttctga    240
 aggatacctt gaggttggtg aaggtgaaca ggtgaccata actctgccaa atatagaagg    300
 ttcaactcca ccagtaactg ttttcaaagg ttcaaaaaaa ccttacttaa aagaatgcat    360
 tttgattatt aaccatgata ctggagaatg tcggctagaa aaactcagca gcaacatcac    420
 tgtaaaaaaa acaagagttg aaggaagcag taaaattcac tatcgtaaag aac           473



      <210> 550
      <211> 413
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(413)
      <223> n = a,t,c or g


      <400> 550
 tttcgtcggg cgcatcctca ttgcagtgcg gcggccctac ctcggccctg gcctgacccc     60
 ggcggccctg cccgcccctc cctccagcat catggccagc ccaagaacca ggaaggttct    120
 taaagaagtc agggtgcagg atgagaacaa cgtttgtttt gagtgtggcg cgttcaatcc    180
 tcagtgggtc agtgtgacct acggcatctg gatctgcctg gagtgctcgg ggagacaccg    240
 cgggcttggg gttcacctca gctttgtgcg ctctgttact atggacaagt ggaaggacat    300
 tgagcttgag aagatgaaag ctggtgggaa tgctaagttc cgagagttcc tggagtctca    360
 ggaggattac gatccttgct ggttcttgca ngagaggtac aacagcaaag ccg           413



      <210> 551
      <211> 4679
      <212> DNA
      <213> Homo sapiens


      <400> 551
 gtttagaggt ttgaattttc tcggagaaag acaggccggc cacgaggaaa acagaaacaa     60
 gccgcagcaa catctaagcc cttgaaagga tcctgagaga ggggggaaag ggaaaacagc    120
 agccaccagc ccaaccactt gtgtcttctg cgcccttccc acctatcttg cccaccacac    180
 cagactacgc tgctcgggac ttgaaatctg tggccgaaag accggtcact acatatcttc    240
 taaaataatc aaccaccctc ccttcccaaa ccacccaaaa ttcactcatc cagcgtttac    300
 ttttttgaat ccactcagaa cttttttctg cgaacccccc ttcccttaaa tgggagttgg    360
 gtggggggga aatgaatact ggagttgggc ctttattttt taaaaagact ttttgaatcc    420
 aatgaggccc cctaaataat tgagttttgg gtcctggttg gttgttttat tttttttcct    480
 ccaaaatttt accccctccc ccctgagccc gaggtgctga cgtcgcaaaa aaattggata    540
 aaaccaccat catgggttcg ggtcccatag accccaaaga acttctcaag ggcctggaca    600
 gcttccttaa ccgagatggg gaagtcaaaa gtgtggatgg gatttccaag atcttcagtt    660
 tgatgaagga agcacgaaag atggtgagtc gatgcactta cttgaacatt ctcctgcaga    720
 cccgttcacc agaaatattg gtcaaattta ttgacgttgg cggctacaaa cttcttaaca    780
 attggctgac gtattcaaag acaaccaaca acattcccct cctccagcaa attctactga    840
 ccctggcagc atctaccgct cactgtagga ccatctcaag gcaggaacaa cacaggctta    900
 aactgggtga aggcaggctg gaggcaagtt caagtgagga tgaagagctc ccgaaattgg    960
 cctcagtcct tgtcagcgac tggatggctg tcatccgctt ttcagagcag tacccagcct   1020
 tgctgagaaa agataagaag gaaacgtaaa gatgaaggaa aaagtcgaac taccctttcc   1080
 ttgagcggac cttttgacaa gaggtgaagg cttgagcccc ggggttgaag gaggccccca   1140
 gagaagaaga gggagaagcc ccaagtctct tcggatccac agcaccccag tcatgccaag   1200
 ttccgtttcc acttggactt agagctggag acaccatccc ttggtgccct gtgaagaaga   1260
 atgccagcac agtggtggtt tctgacaagt acaaccttaa acccattccc ccttcaaacg   1320
 tcagagcaac gtagctgctc caggagatgc cactccccct gcagagaaga aatacaagcc   1380
 actcaacaca acacctaatg ccaccaaaga gatcaaagtg aagatcatcc cgccacagcc   1440
 tatggagggc ctgggctttc tggatgctct tacattcagc ccctgttcca ggcatcaaaa   1500
 ttaagaagaa aaaaaaagta ctgtcaccta cggctgccaa gccaagcccc tttgaaggga   1560
 aaacgagcac agaaccaagc acagccaaac cttcttcccc agaaccagca ccaccttctg   1620
 aggcaatgga cgcagaccgt ccaggcaccc cggttccccc tgttgaagtc ccggagctca   1680
 tggatacagc ctctttggag ccaggagctc tggatgccaa gccagtggag agtcctggag   1740
 atcctaacca actgacccgg aaaggcagga agaggaaaag tgtgacatgg cctgaggaag   1800
 gcaaactgag agaatatttc tattttgaat tggatgaaac tgaacgagta aatgtgaata   1860
 agatcaagga ctttggtgag gcggctaagc gagagatact gtcagaccga catgcatttg   1920
 agacagcgcg gcgtctgagc catgataaca tggaggagaa ggtgcccttg ggtgtgcccc   1980
 cggcccctgg ttctgccctc acctcttgtc acccctggaa gcaatagtca gggagcgata   2040
 tattcaggct gagccgggag aaagggaatc ctttcaagga gctctttctg aaccaaggag   2100
 agtccttcat gagcctgatc ctgagccctt cgagcccata ccccctaaac tcatccccct   2160
 agatgaggag tgttccatgg atgagactcc gtatgttgag actctggaac ctggggggtc   2220
 aggtggctca cctgatgggg caggaggctc caagttgcct ccagttctgg ccaatcttat   2280
 gggaagcatg ggtgctggaa agggccccca aggccctgga ggaggaggca ttaatgtcca   2340
 agagatcctc acctccatca tgggtagccc aaacagtcat ccttcagagg aactactgaa   2400
 acaaccagac tattcggaca agatcaagca gatgctggtg ccacatggac tcctaggccc   2460
 tggcccaata gccaatggtt tcccaccagg gggtcctggg ggccccaagg gcatgcagca   2520
 ctttccccct ggacctgggg gacctatgcc aggtccccat ggaggccctg gtgggccagt   2580
 gggtccacgt cttctgggtc ctccaccccc tccccgggga ggtgatccct tctgggatgg   2640
 cccgggcgac cctatgcggg gtggcccaat gcgggggggt ccaggaccag gtcctggacc   2700
 ataccataga ggccgaggtg gccgaggagg aaacgaacct cctcctcctc ctcctccatt   2760
 ccgaggcgcc agaggaggtc gctctggagg aggaccccca aatggacgag ggggccctgg   2820
 tgggggcatg gttggaggtg gtgggcatcg tcctcacgaa ggccctggtg ggggcatggg   2880
 caacagcagt ggacatcgtc cccacgaagg ccctggcggt ggcatgggaa gtgggcatcg   2940
 cccccatgaa ggccctggtg gtagcatggg tgggggtgga ggacatcgtc cccacgaagg   3000
 ccctggcggt ggcatcagtg gtggcagtgg ccatcgtccc catgaaggcc ctggcggagg   3060
 aatgggtgcc ggtggtggac atcgccccca cgaaggccct ggcggaagca tgggtggaag   3120
 tggtggacat cgtccccatg aaggccctgg acacgggggg ccccatggcc accggcttca   3180
 tggatgtccc tggtcaccga ggccatgacc attcgagggc cgccacctca tgagcaccgt   3240
 ggccatgatg gtcctgggcc acgggtgagg gggccaccga gggcacgatt ggaaggccac   3300
 aaccttggga ggagacatgt caaaccgccc tgtctgccga catttcatga tgaaggtcaa   3360
 ctgccgctat gagaacaact gtgccttcta ccacccgggt gtcaatgggc cccccctgcc   3420
 ctaaggacca tttgcctgcc ctgttcacac aacccctgtg gactgcagcc tcgctctttc   3480
 caccctgtta tggcttctgt gaggcccatt ttcccttttc cccagctgat gaggagccgg   3540
 ccccctcagt tcccacttgc ttggggttcc ggggggtttt ctgatcactg ggtgcgcatt   3600
 gatgtacata tttttcctcc agtctggggg aaggagagag actgggaaac gttcctggga   3660
 ttgttgaaga ggagacccag tttggcttca ctttttgaga agattcgccc tgtaacccca   3720
 aacccctttc cagtattaac ccttaaatgc ttggaggaac ctaaaagctg gttattcctg   3780
 ggcgaaacac ccctaccctt cttatttgcg gggttcccca catggcacac agaactcttg   3840
 acacaggatt cagctggcat ttaaaggaaa tcattcccag gttaagtttc attatttccc   3900
 tcatgggggt gggggaagat ggttgaaagg ggtattgtat atcccactgc actgagaggg   3960
 ctcaatcagc tggatttgag ttcttgggaa cacacattat ccccaccccc tcccccaagc   4020
 gtgggctcac cattcttaag tcctttctca agtgggacct tcaacttttc tgtgaacacc   4080
 cagtctggcg tccttggggt ctgctagggt tcgatgaatg gcgaactcgt aatctggaat   4140
 ccgggtgcaa agttttaagc ttggcagaag gtgaagaccc ggtgggtgct ggtctggcct   4200
 ttgcccaact attaggccag tcttggagac tttgataaaa tacttcagtg agacccagct   4260
 tctcatcaaa cttggggccc cggccgtgct gggccctgaa aagtcaacac ctaacatgca   4320
 ctgccctttg gggaagtcca gcctcactcc cctgcctccc cacccggaac ccttgcccag   4380
 ccgtgaagga ggccttcccc ggtacttcac ccctgtcaac ccacctctga atcccccacc   4440
 caggcgcctt ccctgggtgg attcaacaag atgattttgc cctttaccca gttctctcct   4500
 tcactttggc gatcagttgt tttctatgaa aacagtggat tggttgggtt ttgtgcaggg   4560
 tcttgggtta gagccaaaat ggatttgagg atgagtattt tttttttttt ttggttttgt   4620
 atattttgta cattaataat aaatcagtgg aaagagaagc agcttattta aaaaaaaaa    4679



      <210> 552
      <211> 837
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(837)
      <223> n = a,t,c or g


      <400> 552
 ctaanccttt nattttgaag ggagtccatg aatcccctaa agntttttaa gtaggggagc     60
 caatttaatt gaantcctat agtttttaga agatgggtat gttggtttca gcaagtgtgt    120
 atgtagtggc cagggtgagg gtgtggatgg accttagaga caggagaaca actggaagac    180
 ccatataata gcccaagtta aatgatgaag accctgaagt agagcaactg cagagagaat    240
 ggaaagccac gggatttaag aagatttttt aaatgtcctt agtactggat ataggcccaa    300
 gagaaaccag aaagagtcaa aatcaacttc tgagagtgaa ggatgcttgt gggatggatt    360
 agaggttaaa gaaattgcca aggaaagggg ccagctaggg acaaataata ctgcacagcc    420
 ataaaaaagg atgagttcat gtcctttgca gggacatgga tgaaactgga aaccatcatt    480
 ctcagcaaac tacagcaagg acagaaaacc aaacaccgca tgcttctcac tcacaagtgg    540
 gagttgatac aatgagaaca cttggacaca ggatggggaa catcagacac cgtggggcct    600
 gttgaggggt ggggggtggg gggcaagggg agggatagca ttaggagaaa tacctaatac    660
 ctaatgcatg tggggcttaa aacttagatg acaggttgat aggtgcagca aaccaccatg    720
 ggggttgata ggtgcagcaa aggaccatgg cacatgtatt cctatgtaac aaacctgcgc    780
 gttctgcaca tgtattctag aacttaaagt cgaatgatta ataatatgtc cctaaaa       837



      <210> 553
      <211> 1066
      <212> DNA
      <213> Homo sapiens


      <400> 553
 tttcgtgcca tggaaacgaa agcggccaag tttatgcttc gtcctgacgc gccgcctccc     60
 gtgggctgcg gccggctaag ccgcggcgga caactatgct gaaagccaag atcctcttcg    120
 tggggccttg cgagagtgga aaaactgttt tggccaactt tctgacagaa tcttctgaca    180
 tcactgaata cagcccaacc caaggagtga ggatcctaga atttgagaac ccgcatgtta    240
 ccagcaacaa caaaggcacg ggctgtgaat tcgagctatg ggactgtggt ggcgatgcta    300
 agtttgagtc ctgctggccg gccctgatga aggatgctca tggagtggtg atcgtcttca    360
 atgctgacat cccaagccac cggaaggaaa tggagatggg gtattcctgc ttttgtccaa    420
 cagccgtcct tacaggacac acagtgtatg cttaattgca caccacaaac caggctctgg    480
 agatgataaa ggaagcctgt ctttgtcgcc acccttgaac aagctgaagc tggtgcactc    540
 aaacctggaa gatgaccctg aggagatccg gatggaattc ataaagtatt taaaaagcat    600
 aatcaactcc atgtctgaga gcagagacag ggaggagatg tcaattatga cctagccagc    660
 cttcacctgg gactgccaca tccccagtga aatcagcatg tttctcggtg cagatctgaa    720
 gatcacatcg agctgctgat gtgtttcttc tccctctgac tgcagaggaa gttgttccta    780
 cctgcaggaa ggcaccttgc acccaagggc gttcactcag accaatctgt ggtttggccc    840
 tgagttcagt tgagaaaatc ctattatcaa atttggattt cctggcccca gaacttccca    900
 aagacctgta aaatggaggg atttaccacc tcacatatgt ccagttaaac agtttgtgga    960
 cttgtaaccg tcgcagccca atgatacaac agtagtttaa tcacgtgtat tggcttgaat   1020
 gtgattttca ttccttgatt cacccaacaa ataccgactg gctgaa                  1066



      <210> 554
      <211> 1540
      <212> DNA
      <213> Homo sapiens


      <400> 554
 ctgacttacc ggatcggaat tcccgggccg aggctggtgc agcggctcca ggaggtctcc     60
 ctgttgcagt ttatgagggc cgacccaggg gtgctggccg ccctctgtga gaaaactgac    120
 aatgacatcc gggcctgcat caacaccctg cagttcctgt acagccgggg ccagcgggag    180
 ctgagcgtgc gggacgtgca ggccacacgc gtgggcctca aggaccagcg cagagggctc    240
 ttctcggtgt ggcaggaggt cttccagctg cctcgagccc agagcacccc acctgcaggc    300
 gccgtgtggg ccaggacccc gccctgcctg ctgacacact cctgctgggt gacggggacg    360
 cgggctccct cacctccgcc tcacagcgat tctaccgtgt cctgcatgcc gctgcctctg    420
 cgggcgagca cgagaaggtg gtccagggct tgtttgacaa cttcctgcgt ctgcggctgc    480
 gagactccag cctgggtgct gtgtgtgtgg ccctcgactg gctggccttc gatgacctgc    540
 tggcgggggc tgctcatcac agccagagct tccagctgct gcgctaccca cccttcctgc    600
 ccgtggcctt ccatgtgctg tttgcttcca gccacacacc caggatcacc ttccccagca    660
 gccagcagga ggcccagaac cggatgagcc agatgaggaa cctgatccag acgctggtgt    720
 ccggcatcgc gccagccacg cgcagccggg ccacgcccca ggccctgctc ctcgatgccc    780
 tctgcctgct cctggacatt cttggcaccc aagctccgcc ccgtgagcac acagctgtac    840
 agcacccgtg aaaagcaaca gctggccagc ctggtgggca cgatgctcgc ttacagcctg    900
 acctaccgcc aggagcgcac gcccgatggc cagtacatct acaggctgga gccgaacgtg    960
 gaggaactct gccgcttccc tgagctgcct gcccgcaagc ccctcaccta ccagacgaag   1020
 cagctcatcg cccgcgagat cgaggtggag aagatgcggc gggcggaggc ttctgcccgg   1080
 gtagagaaca gcccccaggt ggatgggagc cccccagggc tcgagggtct gctggggggc   1140
 attggggaga aaggggtgca ccgacctgcc ccacgcaacc atgagcagcg gctggaggca   1200
 catcatgagg cagaagcggc ccgggaagac cagcctgaga agggccttct ttggacgtgt   1260
 ggtcgtcagg agcacagcag tcccgagtgc aggggaacag ggccccggag caggactcag   1320
 tggagcggcg catgggcaca gcggtgggca ggagcgaggt ctggttccgc ttcaacgagg   1380
 gtgtctccaa cgccgctgcg gcgcagcctg tacatcaggg acttgctcta gttctctgag   1440
 ccgcggacat gccctcgcat tgcttcccgc agagtgcaga gacaggaagc tggagatgtc   1500
 tttataaagt cacaccttta cagactgtaa aaaaaaaaaa                         1540



      <210> 555
      <211> 592
      <212> DNA
      <213> Homo sapiens


      <400> 555
 ttttgcctaa gatacaatga taagtaaaaa catgttacag agtaataacg tgttgcatag     60
 gacaatactg taaatgtggt tcattccatc aacagacact gagccctgcg acgtgcctgg    120
 ctctattcta catctgaggg acacaaggtg aacaagacca ggccactgta ttcaacatct    180
 acatttaatg gaaatttttg aaagaagact tgagagttta taaacagtgg tcttccagca    240
 tccagggagt aggccctaga agaagaggag gtccaagaag tggcttttct tattatcttc    300
 ttaactcttc aaaattttta ctatgaagcc aattattatt ttttattaaa attttaggcc    360
 aggcttatgg ctgtaatcct agcagtttgg gaggccaagg tgagcggatc acttgaggtt    420
 gggagttcga gaccagcctg accaacatgg agaaactctg tctctactta aaaaaaaata    480
 caaaattagc caggcatggt ggcacatgcc tgtagtccca gctactcagg agactgaggc    540
 aggggaattg cctgaacctg ggagacagag gttgcaatga gccaagatca cg            592



      <210> 556
      <211> 1010
      <212> DNA
      <213> Homo sapiens


      <400> 556
 cggacgcgtg ggcggacgcg tgggcgtagc tgtcggagcg gttagttcga tttcgagctc     60
 gaggtttccc ccgccgccag gctgacttct catcgcttgt ttttcttttt gcatttttcc    120
 tcccaccgcc gttgccgccc tccccgtcct ggccgtccgc cctccgccct ctgcagggac    180
 atctctacac cgttcccatc cgggaacagg gcaacatcta caagcccaac aacaaggcca    240
 tggcagacga gctgagcgag aagcaagtgt acgacgcgca caccaaggag atcgacctgg    300
 tcaaccgcga ccctaaacac ctcaacgatg acgtggtcaa gattgacttt gaagatgtga    360
 ttgcagaacc agaagggaca cacagttttg acggcatttg gaaggccagc ttcaccacct    420
 tcactgtgac gaaatactgg ttttaccgct tgctgtctgc cctctttggc atcccgatgg    480
 cactcatctg gggcatttac ttcgccattc tctctttcct gcacatctgg gcagttgtac    540
 catgcattaa gagcttcctg attgagattc agtgcatcag ccgtgtctat tccatctacg    600
 tccacaccgt ctgtgaccca ctctttgaag ctgttgggaa aatattcagc aatgtccgca    660
 tcaacttgca gaaagaaata taaatgacat ttcaaggata gaagtatacc tgattttttt    720
 tccttttaat tttcctggtg ccaatttcaa gttccaagtt gctaatacag caacaattta    780
 tgaattgaat tatcttggtt gaaaataaaa agatcacttt ctcagttttc ataagtatta    840
 tgtctcttct gagctatttc atctattttt ggcagtctga atttttaaaa cccatttaaa    900
 tttttttcct taccttttta tttgcatgtg gatcaaccat cgctttattg gctgagatat    960
 gaacatattg ttgaaaggta atttgagaga aatatgaaga actgaggagg              1010



      <210> 557
      <211> 527
      <212> DNA
      <213> Homo sapiens


      <400> 557
 tttttttttt gtatgtggaa aaatgtattt ttgtaccata tctcatacct ggagagaaac     60
 cttttttcta tcttcagggc tgtagaatat attagcgtaa cactttcact gaatgtgacg    120
 taaaagcatt ctgatgaaaa ctggttctgt tataattaag actcagtgtt taaaaatatc    180
 cttaatccag tgttaatttc ccccagtgtt tccagtatcc acagtaaata cttgttttac    240
 tgagaacaga aaataatccc agaaaaggaa aaggaccagc ctctctctag attgctggaa    300
 ttgtatggat gtgttggggt tggtttagtg atctcttcct tgacacccta gcaaagatgc    360
 ttttgtggag tgcaaacctt tcataaatat actttccagg ctgggtgcag tggctcaagc    420
 ttgtaatccc agcactttgg gaggccaagg cgggtggatc acttgcggtc gggagttcga    480
 gaccagcctg accaacatag tgaaatcccg tctctaccaa aaaatac                  527



      <210> 558
      <211> 1258
      <212> DNA
      <213> Homo sapiens


      <400> 558
 agctgtagac cacgattacg cctagcttgg cacgagccag gaggcgtcgg ggctgcgccg     60
 tacaacttcc ggctgtaaag atggcggctt cctagtgagt cggcggctga tttagaagga    120
 ggttcaggct acggtgagcc gaagccacac aggagccatg gaagtggcag agcccagcag    180
 ccccactgaa gaggaggagg aggaagagga gcactcggca gagcctcggc cccgcactcg    240
 ctccaatcct gaaggggctg aggaccgggc agtaggggca caggccagcg tgggcagccg    300
 cagcgagggt gagggtgagg ccgccagtgc tgatgatggg agcctcaaca cttcaggagc    360
 cggccctaag tcctggcagg tgcccccgcc agcccctgag gtccaaattc ggacaccaag    420
 ggtcaactgt ccagagaaag tgattatctg cctggacctg tcagaggaaa tgtcactgcc    480
 aaagctggag tcgttcaacg gctccaaaac caacgccctc aatgtctccc agaagatgat    540
 tgagatgttc gtgcggacaa aacacaagat cgacaaaagc cacgagtttg cactggtggt    600
 ggtgaacgat gacacggcct ggctgtctgg cctgacctcc gacccccgcg agctctgtag    660
 ctgcctctat gatctggaga cggcctcctg ttccaccttc aatctggaag gacttttcag    720
 cctcatccag cagaaaactg agcttccggt cacagagaac gtgcagacga ttcccccgcc    780
 atatgtggtc cgcaccatcc ttgtctacag ccgtccacct tgccagcccc agttctcctt    840
 gacggagccc atgaagaaaa tgttccagtg cccatatttc ttctttgacg ttgtttacat    900
 ccacaatggc actgaggaga aggaggagga gatgagttgg aaggatatgt ttgccttcat    960
 gggcagcctg gataccaagg gtaccagcta caagtatgag gtggcactgg ctgggccagc   1020
 cctggagttg cacaactgca tggcgaaact gttggcccac cccctgcagc ggccttgcca   1080
 gagccatgct tcctacagcc tgctggagga ggaggatgaa gccattgagg ttgaggccac   1140
 tgtctgaacc atccctgtac atctgcacct tcttgtgcaa ggaagtcctt ggcctaaagc   1200
 cttggttctc aaactgggtt ccttgggacc tccggggtgg gggggttcca ggaggcat     1258



      <210> 559
      <211> 382
      <212> DNA
      <213> Homo sapiens


      <400> 559
 taacctttcg gcctcgttcc ttgtactcgg tggtgcccac aggggaaacc caggtttcca     60
 gccatgtcca ctaccaccgc ctccggcacc accaatacaa aaatcggttc cagtggcatg    120
 gcagtaagcc tggcccagaa accggagtcc cccagtccag gcctcatatt cctcggacac    180
 agccccagcc agagccacct tctcctgatc agcaagtcac cagatccaac tcagcagccc    240
 cttcggggcg gctctctaac ccacagtgcc ccagggccct ccgtgagcca gcccctggcc    300
 cagttgacgc ctccagcatc tgccccagta ccagcagtct gttcaacatg caaaaatcca    360
 gcctctctgc ccgacactgt at                                             382



      <210> 560
      <211> 662
      <212> DNA
      <213> Homo sapiens


      <400> 560
 caaaggccta gcaccccaca ccccacacac acggcgcagc cttggccctg aatgtggtgc     60
 tccctctgtc gcccggcctg gccgccctca gccctccccg ctgctaatga ctcctgtccc    120
 tgcctttctt cagtgtcttc gagagaactc tgacgtgaag acgcacgggc cttttgaggc    180
 cgtgatgcgc actctctgtg aatgcaagga gacagccagc aagaccctca gcaggtttgg    240
 gattcagccg tgctccatct gcctgggaga tgcaaaggac cccgtctgtc tgccctgcga    300
 ccacgtgcac tgcctgcgct gcctcagggc ctggtttgcc tcaaagcaga tgatatgccc    360
 ctactgttta actgccttgc cagacgaatt ctctccagct gtttcccaag cgcacaggga    420
 agccattgaa aagcatgccc gcttccggca gatgtgcaac agtttcttcg tagacctggt    480
 gtccaccatt tgcttcaagg acaacgctcc gcctgagaag gaagtgattg agagcctgct    540
 ctctctcctc ttcgtccaaa aggggcgctt aagagatgct gcccagagac actgtgaaca    600
 cacaaaatct ctctctccat tcaatgatgt tgtggataag actcctgtca tccgctcagt    660
 ga                                                                   662



      <210> 561
      <211> 3377
      <212> DNA
      <213> Homo sapiens


      <400> 561
 tttcgtatcc agtctgaact aaggcctgag ctgtggatac catggcgcgt gagttagatg     60
 tggtccctgc cctcatgggg ctgacagtcc taaaatcaag tgctaggaca cagtggccat    120
 tgagctggga gcattcttcc ctctaccgct taagccactg atggctgcga gcttgaagag    180
 agggattctg agggagagct tggtccatct ggtcaccaag gctgggcggg acagagcagt    240
 caagaaccac ggtgtggctt gagaaacagt cctgcttcct gagcctcttt gctctgcctc    300
 ttggggcaag ctccttaacc tgtctgtatt tttatgcctc tgtctcccat tcagttcctc    360
 cttgaatacc tctttctaca gagaggcacg ggctcccctg aaggattgtc gaggccaggg    420
 gttcgggaag tacacttgcc atcggtcagg ggacagcttg cctcccacct ttgcctgggg    480
 tgatgggtga atggggattc atcttttcct tgccttgctt tttgagggag atggttgaat    540
 ttaaagctta acagggaaag ccaaaccagc accctccttt gtgctctgag aggttggaga    600
 catctggtcc accccattgc ccctgcccct ggcaagccct gaagtcggga gaggtgacca    660
 caggtctgga aaatcagcca gtgccaacat tgcttgccct gcaagtggca actgagccca    720
 catagcgcat tcatagtttc cctggaccac agccttgggg aaggacggtg ggaaacccga    780
 ggatgttgtg gggttttccc agcttaacgg gacaagttcc cttgccacac ccagtgccca    840
 cgcatgctca catacataca gcagaccaca accctgttgc caagcagtgc ttccaaggga    900
 tagcgatcca gattccaaca ttgtcttgga gagggttagt ccacatccaa gttgcgtgag    960
 ataagatgca aagggctctg tgtggatgag gaacgcacct tagaggagtg ggaaaggcca   1020
 ccagggttgg gccctgttta ggtaattcct gttggcagca cctagagaga gcatctgagc   1080
 tgaaggagtg ggaaactttg cccaagcaat ggcacgggca gcgggctctt tctggcgccc   1140
 tgtgctggag cagggccaag tcttagggca tcacaaacag cccatttgat ggagggagca   1200
 gggacatagc acatttttgt ctgtctttgt gaggctgctt tgctaactct ctgaggagag   1260
 gaagccctct cgggctttcc gtcggctggg gctagtgcca gagaatccct tctcagtggc   1320
 cagcaggttc ctgggaggcc ggcacaaggc accgctcccc actcatgaca ccttggtgca   1380
 gagtgacctc ctgcccagtg caccactccg gccagcccca gccaaacaca caaaagccca   1440
 tggttgcggt tgcatctaca ccgttagttg gcaaaggatc ctgcttgagc tctgcgtggt   1500
 ggccaaggag tagcatggag gagggccctg attttaaaaa ggaaaaatag agaggcctca   1560
 aaacaatgaa acaaagagct tgatatgtca agaggagacc aaggccctgg gaggcatagg   1620
 caagccgggc agagtcagac cagtgccctc ccttgaccat ctcctagcat tccttaacct   1680
 agacaggggc taccccatgt gagtccaagc cagactttgt ggctgtcccc agcctgcaca   1740
 gcccaagccc aggtgaagtg tcctttcttt cccttcctta ctaataatgg gccttcctga   1800
 gacacattca gagaaggatc agagagaaag gagaaccatc caggagagcc acaagcgtcc   1860
 accaaacagt gtctcaggcc tcacctgaag ctgctgttcc tcctatcagc acactagtat   1920
 taaatgggtg ttccataatg aggagaatgg aaataggtac aaggcatcta gcttaggaca   1980
 gaatcggatt tcggcatgtg aaggaatccc agagctgatc tcattgaaat gatctatcgt   2040
 acagacaagg atatgcaaat ccacagaagt gaagggattt ttgctcaaga tcacatagcc   2100
 tggcaaacta aggtaagggt agggcttgta cttgggcctt ctgactcctt gtccagtcag   2160
 tgttctttca tctcaccaca gctgcctcct ttgaaacaga ggtattaaga atctgtcctt   2220
 ctggttcacc ctctcatacc tctttactgc ctctcccaca tcccccacat gcctcccaaa   2280
 atgaaagaca aacaggattg tttctgagga ccaagatcag tctgtctgtg atcagcctgt   2340
 gtgtgggttc acccagtcat ggcaattaag gggcagatct ggggccagtg ggaataggat   2400
 agctgattgg tgtttgttac tgtgaaccct aaaccgtacc ccgtagaatg gtgtctcttg   2460
 ctttgtaaca catcgtgcct tcagtgtgct gtattcctca aaagtgaggg catctcggtc   2520
 cattctgtcc atggccacag ggtgcttata ggctgcttag tcccatggca aggttgccac   2580
 cctgggattt gctgggctgg agttcaacag atgtaaagac ttcagtgaag caataaacac   2640
 aaaactctgg gagaagatat ccagaatttt gtacattact ctgtttcttt ttcaaaaatg   2700
 aggcagatca gatgcccctg agctgcccct ttttttctga ttcccaactg caatgtcctc   2760
 agtcagtgtt gtccctctcg cccggctccc cagctctttg ccaacctctt cacactcccc   2820
 ttgagctgag catcagtcgc ctgtgacgtg gccaccttct gtcctgctcc cactcccgac   2880
 ccatgctgga ccccggagga cctcctgccc cgcccccacc acacacccat atcccccacc   2940
 attccaattt gttctttccc gtggggaatt ttttttttcc cagcgtctcc cacccctccg   3000
 tacaaatccc acacacacac aaattgggtc tgatcctttt ttcccattgg ttaaacattt   3060
 aactcccatg cccagacctt gttttaaccc cctctcacat catgttcttt cccttttttg   3120
 cgagttattt tgcattaacc caactttgtc agtgacagat gccgtatctg agggtggtca   3180
 aaacacgaac ttcagcaggg aagacttctg ggccatggag ggccgtctaa tacatggact   3240
 tataaactga ctgcatgagc aatgaaaagg ccaaattatt ctgaattttt ttttgaatca   3300
 ctgtaaaaaa aactgatttc ttttgtatag agaacactaa acgtataata aaagttgttc   3360
 aaaatggaaa aaaaaaa                                                  3377



      <210> 562
      <211> 1337
      <212> DNA
      <213> Homo sapiens


      <400> 562
 cccacgcgtc cggctatggg gccgggcggt cgtgtggcgc ggctgctccc cccactaatg     60
 tggcgcaggg cggtttcctc ggtggcgggg tccgcggttg gagccgagcc cggggcttcg    120
 gctgctggcc gtgcagcggc tttcccgtag gagcagcgtt ctgccgggct tgccagaccc    180
 caaactttgt ccgcggcctg cacagcgaag cctgggctgg aggagcgggc ggaggggaca    240
 cgtcaacgag ggacgcccag aatcggacgc ggcagatcat actggtccca aggttgacat    300
 cgatatgatg ggttcacttc tgaggcaaga aaatgcaaga ggacatttgt gtgatccagg    360
 ttcctccaga aatgagatat acacgattac tttgtgattg ttagtggaac ttgtacccga    420
 cacttacatg ccatggcctt ctacgttgtg aaaatgtaca aacacctgaa atgtaaacgt    480
 gaccctcatg ttaagataga cgggaagcac actcatgcac tggctctgcg tggattctcg    540
 ccgcatgctg attcatttga tgcttccaga aaccagagaa atctatgaat tagagaaatt    600
 atcgacccta cctctcttat gatgccacca gttagctcag atagcacctg agacactacc    660
 tgaagcactt cattcttgga atagaagatg atacttcatc tgtgactcca gtggagttaa    720
 caatgtgaat aaacatattt ctactcgcac tgcgttagtc atttcagatt tggattgagt    780
 cacttattgg aaaatacagc tcctaaagtc cgtctccttg gttaggctgc tcttaggaca    840
 aggcttgtgt acctcatggg cactcctgct aactggcatg cagagactgt cgataagtga    900
 gctatacctg caaccaaaaa tcagtacatt ctacccaaaa cttatgacac gctgccttta    960
 tcctgggaaa tgtcatcaga atttcctggg agttaggcac tggctcctgt gctttgactt   1020
 cctctgctca gatttttatt aattttaatt taggcttaaa atgtaaatct taaaccctgt   1080
 ttgtttaatg ggaatggcaa aaattttaaa aaataatata aaacatagcc cactggtctt   1140
 atttttatac tttgaggtga taatattctt ctaggaggac ttctgtaacc cttccataat   1200
 actccagtaa cacaagaaag taaacaaagt gtttgttagg aaaaactctg aacgctctag   1260
 ttcttagttc atatgcaaga gtattatcaa ggttcacatt aagtaccatg gctggacatg   1320
 gtataacaga aatctgg                                                  1337



      <210> 563
      <211> 1597
      <212> DNA
      <213> Homo sapiens


      <400> 563
 tttcgtgtgg gtgtacgcgg cgcagcgcgg cagtcctgat ggcccggcat gggttaccgc     60
 tgctgcccct gctgtcgctc ctggtcggcg cgtggctcaa gctaggaaat ggacaggcta    120
 ctagtatggt ccaactgcag ggtgggagat tcctgatggg aacaaattct ccagacagca    180
 gagatggtga agggcctgtg cgggaggcga cagtgaaacc ctttgccatc gacatatttc    240
 ctgtcaccaa caaagatttc agggattttg tcagggagaa aaagtatcgg acagaagctg    300
 agatgtttgg atggagcttt gtctttgagg actttgtctc tgatgagctg agaaacaaag    360
 ccacccagcc aatgaagtct gtactctggt ggcttccagt ggaaaaggca ttttggaggc    420
 agcctgcagg tcctggctct ggcatccgag agagactgga gcacccagtg ttacacgtga    480
 gctggaatga cgcccgtgcc tactgtgctt ggcggggaaa acgactgccc acggaggaag    540
 agtgggagtt tgccgcccga gggggcttga agggtcaagt ttacccatgg gggaactggt    600
 tccagccaaa ccgcaccaac ctgtggcagg gaaagttccc caagggagac aaagctgagg    660
 atggcttcca tggagtctcc ccagtgaatg ctttccccgc ccagaacaac tacgggctct    720
 atgacctcct ggggaacgtg tgggagtgga cagcatcacc gtaccaggct gctgagcagg    780
 acatgcgcgt cctccggggg gcatcctgga tcgacacagc tgatggctct gccaatcacc    840
 gggcccgggt caccaccagg atgggcaaca ctccagattc agcctcagac aacctcggtt    900
 tccgctgtgc tgcagacgca ggccggccgc caggggagct gtaagcagcc gggtggtgac    960
 aaggagaaaa gccttctagg gtcactgtca ttccctggcc atgttgcaaa cagcgcaatt   1020
 ccaagctcga gagcttcagc ctcaggaaag aacttcccct tccctgtctc ccatccctct   1080
 gtggcaggcg cctctcacca gggcaggaga ggactcagcc tcctgtgttt tggagaaggg   1140
 gcccaatgtg tgttgacgat ggctgggggc caggtgtttc tgttagaggc caagtattat   1200
 tgacacagga ttgcaaacac acaaacaatt ggaacagagc actctgaaag gccatttttt   1260
 aagcatttta aaatctattc tctccccctt tctccctgga tgattcagga agctgacatt   1320
 gtttcctcaa ggcagaattt tcctggttct gttttctcag ccagttgctg tggaaggaga   1380
 atgctttctt tgtggcctca tctgtggttt cgtgtccctc tgaaggaaac tagtttccac   1440
 tgtgtaacag gcagacatgt aactatttaa agcacagttc agtcctaaaa gggtctggga   1500
 gaaccagatg atgtactagg tgaagcattg cattgtggga atcacaaagc aaatagtact   1560
 ccagaaagac aaatatcaga agcttcctat tcttttt                            1597



      <210> 564
      <211> 703
      <212> DNA
      <213> Homo sapiens


      <400> 564
 actgacatcc gtatgaccat gactacggat tcgctgtccg tcccctgaca tccacgcgac     60
 tgggagaacc ctggcgccac cctgcttaat cgcgttgctc tacacagttc gccactggta    120
 acatttcacc caggaagggt gtcctcggga gaccctggcg ggagcccgga acccgcggag    180
 gggctgagga gccgcccagc cctctggcgg gttgggagcg aggcccctgc ccttgctgac    240
 aggccacatg accttggtct ttgatacaga aagccaccat ttaatgacag tgctctggct    300
 tggaaactta ggtgagtttc tagccaataa cttttacgac aaatagaaat agggataatg    360
 gcccggccgt ctcttctgag gattctgtgg tactttaatt ataatttccc ccattattaa    420
 agtcaacccg ccactttaaa aggcgcccct gaagatcagg atccagcagg aagttattgc    480
 gaccatcatt tattccgtgc gtggggacac agttggggct ggtactttat aacaatcact    540
 tttctggggt tttttcccca aaattctttt tctccatatt gaagccatgg aatataaatt    600
 ttaacttttt ttttgggagg gggggtggtg ttttcccccg ggggggtggg gaggggggag    660
 ttgggtaagt gaacccccct tccggggtag gagtttccgc ctg                      703



      <210> 565
      <211> 76
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(74)
      <223> Xaa = any amino acid or nothing 


      <400> 565
 Ile Met Lys Arg Ala Pro Val Ile Pro Lys His Thr Leu Asn Thr Gln
   1               5                  10                  15    
 Pro Val Glu Asp Thr Ser Leu Ser Thr Pro Ala Ala Pro Met Val Asp
              20                  25                  30        
 Ser Leu Ile Ala Arg Val Gly Val Met Ala Arg Gly Asn Pro Ile Thr
          35                  40                  45            
 Xaa Pro Val Cys Gly Arg Asp Val Lys Phe Thr Leu Glu Val Leu Arg
      50                  55                  60                
 Gly Asp Ser Ala Asp Lys Pro Ser Arg Val
  65                  70                



      <210> 566
      <211> 68
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(64)
      <223> Xaa = any amino acid or nothing 


      <400> 566
 Ser Pro Thr Gly Asp Arg Ala Pro Ser Arg Gly Arg Glu Ala Val Ser
   1               5                  10                  15    
 Lys Val Lys Trp Arg Leu Val Pro Glu Gln Pro Arg Thr Ser Cys Pro
              20                  25                  30        
 Ser Ala Arg Cys Pro His Pro Cys Leu Pro Pro Thr Pro Arg Pro Cys
          35                  40                  45            
 Asn Pro Ala Xaa Cys Pro Glu Pro His Pro Gly Ala Cys Met Arg Pro
      50                  55                  60                





      <210> 567
      <211> 42
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(40)
      <223> Xaa = any amino acid or nothing 


      <400> 567
 Ser Gln His Phe Gly Arg Pro Arg Arg Ala Asp His Leu Arg Leu Gly
   1               5                  10                  15    
 Val Xaa Glu Gln Pro Asp Gln His Gly Glu Ser Pro Val Ser Lys Asn
              20                  25                  30        
 Thr Lys Ile Ser Trp Ala Trp Trp
          35                  40



      <210> 568
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 568
 Leu Arg Glu Leu Gly Gly Pro Gly Thr Pro His Ser Arg Glu Met Ala
   1               5                  10                  15    
 Leu Cys Tyr Gly Thr Phe Trp Gly Tyr Pro Lys Met Leu Glu Ala Ala
              20                  25                  30        
 Asn Leu Met Glu Gly Leu Val Asp Ile Gly Pro Trp Val Thr Leu Pro
          35                  40                  45            
 Arg Gly Gln Pro Glu Val Leu Glu Trp Gly Leu Pro Lys Asp Gln Asp
      50                  55                  60                
 Ser Val Ala Phe Glu Asp Val Ala Val Asn Phe Thr Gln Glu Glu Trp
  65                  70                  75                  80
 Ala Leu Leu Gly Pro Ser Gln Lys Asn Leu Tyr Arg Asp Val Met Arg
                  85                  90                  95    
 Glu Thr Ile Met Asn Leu Asn Cys Ile Gly Met Lys Trp Glu Asn Gln
             100                 105                 110        
 Asn Ile Asp Asp Gln His Gln Asn Leu Arg Arg Asn Pro Arg Thr Gln
         115                 120                 125            





      <210> 569
      <211> 174
      <212> PRT
      <213> Homo sapiens


      <400> 569
 Val Cys Gly Phe Gly Val Ser Trp Ala Pro His Leu Leu Leu Ala His
   1               5                  10                  15    
 Leu Pro Ala Ala Leu Ser Pro Gly Ser Val Arg Val Pro Lys Gly Gly
              20                  25                  30        
 His Ser Gly Pro Val Ala Met Gln Gly Arg Arg Pro Ala Ala Ala Asp
          35                  40                  45            
 Ala Ser Arg Gly Leu Tyr Lys Met Pro Pro Tyr Thr Pro Phe Phe Ala
      50                  55                  60                
 Asn Glu Gly Ser Ser Val Gly Val Pro Pro Thr Pro Met Tyr Ala Ala
  65                  70                  75                  80
 Leu Gly Ser Leu Leu Leu Leu Pro Ala Gly Arg Pro Arg Thr Glu Gly
                  85                  90                  95    
 Leu Pro Gly Leu Tyr Cys Pro Gly Cys Lys Ser Ser Ala Gln Gly Glu
             100                 105                 110        
 Gly Met Trp Pro Gly Asp Pro Gly Pro Gly Ile Gln Gly Pro Gly Leu
         115                 120                 125            
 Gly Pro Gln Asp Arg His Gly Gly His Arg Gly Gln Ala Ser Pro Pro
     130                 135                 140                
 Phe Pro Leu Pro Thr Ala Ser Ser Pro Phe Leu His Ser Gln Leu Cys
 145                 150                 155                 160
 Ile Ala Gly Ala Leu Glu Asp Thr Arg Ile Arg Arg
                 165                 170        



      <210> 570
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 570
 Phe Leu Lys Leu Gln Gln Lys Trp Ser Tyr Lys His Lys His Gln Arg
   1               5                  10                  15    
 Pro Met Asn Gly Phe Lys Ala His Met Cys Ser Val Val Phe Met Ala
              20                  25                  30        
 Leu Thr Asp Pro Ser Ala Gln Ile Gln Leu Val Gly Ile Arg Thr Leu
          35                  40                  45            
 Thr Val Leu Gly Ala Gln Pro Asp Leu Leu Ser Tyr Glu Asp Leu Glu
      50                  55                  60                
 Leu Ala Val Gly Leu Leu Tyr Arg Leu Ser Phe Leu Lys Lys Asp Ser
  65                  70                  75                  80
 Gln Ser Cys Arg Val Ala Ala Leu Lys Ala Ser Gly Thr Leu Ala Ala
                  85                  90                  95    
 Leu Tyr Pro Val Ala Phe Ser Ser Arg Leu Val Pro Lys Leu Ala Glu
             100                 105                 110        
 Glu Leu Arg Val Gly Glu Ser Asn Leu Thr Asn Ala Arg Cys Leu Val
         115                 120                 125            
 Pro Gly Cys Ala
     130        



      <210> 571
      <211> 117
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(117)
      <223> Xaa = any amino acid or nothing 


      <400> 571
 Ser Met Pro Gly Trp Arg Leu Leu Thr Gln Gly Gly Ala Gln Val Leu
   1               5                  10                  15    
 Gly Arg Leu Gly Asp Gly Leu Gly Ala Ala Leu Gly Pro Gly Asn Arg
              20                  25                  30        
 Thr His Ile Trp Leu Phe Val Arg Gly Leu His Gly Lys Ser Gly Ser
          35                  40                  45            
 Trp Trp Asp Glu His Leu Ser Glu Lys Asn Ala Pro Phe Ile Lys Gln
      50                  55                  60                
 Leu Val Pro Asp Glu Asn Lys Ala Gln Leu Pro Arg Lys Leu Cys Pro
  65                  70                  75                  80
 Leu Lys Asp Glu Pro Trp Ala Ile Leu Pro Trp Glu Thr Gly Ser Phe
                  85                  90                  95    
 Lys Val Trp Leu Ile Xaa Leu Glu Gly Trp Ala Cys Trp Pro Phe Cys
             100                 105                 110        
 Ser His Gly Met Gly
         115        



      <210> 572
      <211> 80
      <212> PRT
      <213> Homo sapiens


      <400> 572
 Phe His Phe Phe Arg Lys Pro Pro Glu Ser Lys Lys Pro Ser Val Pro
   1               5                  10                  15    
 Glu Thr Glu Ala Asp Gly Phe Val Leu Leu Gly Asp Thr Thr Asp Glu
              20                  25                  30        
 Gln Arg Met Thr Ala Arg Gly Lys Thr Ser Asp Ile Glu Ala Asn Gln
          35                  40                  45            
 Pro Leu Glu Thr Asn Lys Glu Asn Ser Ser Ser Val Thr Val Ser Asp
      50                  55                  60                
 Pro Glu Met Glu Asn Lys Ala Gly Gln Thr Leu Glu Asn Ser Ser Leu
  65                  70                  75                  80





      <210> 573
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 573
 Arg Ser Arg Asp Trp Ser Asn Met Asn Arg Glu Asp Arg Asn Val Leu
   1               5                  10                  15    
 Arg Met Lys Glu Arg Glu Arg Arg Asn Gln Glu Ile Gln Gln Gly Glu
              20                  25                  30        
 Asp Ala Phe Pro Pro Ser Ser Pro Leu Phe Ala Glu Pro Tyr Lys Val
          35                  40                  45            
 Thr Ser Lys Glu Asp Lys Leu Ser Ser Arg Ile Gln Ser Met Leu Gly
      50                  55                  60                
 Asn Tyr Asp Glu Met Lys Asp Phe Ile Gly Asp Arg Ser Ile Pro Lys
  65                  70                  75                  80
 Leu Val Ala Ile Pro Lys Pro Thr Val Pro Pro Ser Ala Asp Glu Lys
                  85                  90                  95    
 Ser Asn Pro Asn Phe Phe Glu Gln Arg His Gly Gly Ser His Gln Ser
             100                 105                 110        
 Ser Lys Trp Thr Pro Val Gly Pro Ala
         115                 120    



      <210> 574
      <211> 31
      <212> PRT
      <213> Homo sapiens


      <400> 574
 Phe Lys Phe Pro Gly Gly Arg Ile His Arg His Leu Lys Ser Arg Thr
   1               5                  10                  15    
 Asn Ser His Gly Arg Val Gly Ala Thr Ala Ala Val Tyr Ser Ala
              20                  25                  30    



      <210> 575
      <211> 104
      <212> PRT
      <213> Homo sapiens


      <400> 575
 Leu His Ser Ala Phe Pro Cys Glu Pro Arg Met Ala Asp Gln Val Thr
   1               5                  10                  15    
 Leu Glu Asp Ala Leu Ser Asn Val Asp Leu Leu Glu Glu Leu Pro Leu
              20                  25                  30        
 Pro Asp Gln Gln Pro Cys Ile Glu Pro Pro Ala Ser Ser Leu Leu Tyr
          35                  40                  45            
 Gln Pro Asn Phe Asn Thr Asn Phe Glu Asp Arg Asn Ala Phe Val Thr
      50                  55                  60                
 Gly Ile Ala Arg Tyr Ile Glu Gln Ala Thr Val His Ser Ser Met Asn
  65                  70                  75                  80
 Glu Met Leu Glu Glu Gly Gln Glu Tyr Ala Val Met Leu Tyr Thr Trp
                  85                  90                  95    
 Arg Ser Cys Ser Arg Ala Ile Pro
             100                



      <210> 576
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 576
 Ser Arg Ser Ala Gln Pro Pro Ala Phe Ser Leu Leu Asp Leu Gly Thr
   1               5                  10                  15    
 Glu Arg Arg Trp Pro Ala Gly Met Glu Lys Ser Arg Met Asn Leu Pro
              20                  25                  30        
 Lys Gly Pro Asp Thr Leu Cys Phe Asp Lys Asp Glu Phe Met Lys Val
          35                  40                  45            
 Arg Ala Ala Ser Ala Pro Arg Ser Arg Ala Met Arg Val Pro Leu Pro
      50                  55                  60                
 Cys Ala Leu Cys Gly Arg Leu Phe Gly Arg Leu Leu Leu Pro Ala His
  65                  70                  75                  80
 Ala Gln Cys Gln Val Leu Arg Arg Asp Leu Ala Ala Leu Arg Asn Glu
                  85                  90                  95    
 Ser Phe Gly Val Arg Phe Gly Gly Cys Ser Leu Glu Lys Ala Leu Leu
             100                 105                 110        





      <210> 577
      <211> 181
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(174)
      <223> Xaa = any amino acid or nothing 


      <400> 577
 Phe Val Ser Val Pro Ser Pro Cys Gly Gly Ile Arg Glu Ala Glu His
   1               5                  10                  15    
 Gly Gln Glu Val Gly Glu Gly Gly Ala Pro Pro Arg Trp Arg Leu Leu
              20                  25                  30        
 Ser Leu Arg Arg Thr Tyr Ser Gly Ser Gln Leu Arg Arg Val Glu Gly
          35                  40                  45            
 Lys Cys Cys Cys Trp Gly Leu Gln Thr Arg Met Asp Asn Val Gln Pro
      50                  55                  60                
 Arg Lys Ile Lys His Arg Pro Phe Cys Phe Ser Val Lys Gly His Val
  65                  70                  75                  80
 Lys Met Leu Arg Leu Asp Ile Ile Asn Ser Leu Val Thr Thr Val Phe
                  85                  90                  95    
 Met Leu Ile Val Ser Val Leu Ala Leu Ile Pro Glu Thr Thr Thr Leu
             100                 105                 110        
 Thr Val Gly Gly Gly Val Phe Ala Leu Val Thr Ser Lys Xaa Cys Cys
         115                 120                 125            
 Leu Ala Asp Arg Gly Pro Leu Ile Tyr Arg Lys Leu Leu Phe Asn Pro
     130                 135                 140                
 Gln Pro Val Pro Tyr Gln Lys Lys Pro Val His Glu Lys Lys Arg Ser
 145                 150                 155                 160
 Phe Cys Asn Phe Ile Leu Pro Phe Lys Phe Asp Thr Lys Tyr
                 165                 170                



      <210> 578
      <211> 181
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(174)
      <223> Xaa = any amino acid or nothing 


      <400> 578
 Phe Val Ser Val Pro Ser Pro Cys Gly Gly Ile Arg Glu Ala Glu His
   1               5                  10                  15    
 Gly Gln Glu Val Gly Glu Gly Gly Ala Pro Pro Arg Trp Arg Leu Leu
              20                  25                  30        
 Ser Leu Arg Arg Thr Tyr Ser Gly Ser Gln Leu Arg Arg Val Glu Gly
          35                  40                  45            
 Lys Cys Cys Cys Trp Gly Leu Gln Thr Arg Met Asp Asn Val Gln Pro
      50                  55                  60                
 Arg Lys Ile Lys His Arg Pro Phe Cys Phe Ser Val Lys Gly His Val
  65                  70                  75                  80
 Lys Met Leu Arg Leu Asp Ile Ile Asn Ser Leu Val Thr Thr Val Phe
                  85                  90                  95    
 Met Leu Ile Val Ser Val Leu Ala Leu Ile Pro Glu Thr Thr Thr Leu
             100                 105                 110        
 Thr Val Gly Gly Gly Val Phe Ala Leu Val Thr Ser Lys Xaa Cys Cys
         115                 120                 125            
 Leu Ala Asp Arg Gly Pro Leu Ile Tyr Arg Lys Leu Leu Phe Asn Pro
     130                 135                 140                
 Gln Pro Val Pro Tyr Gln Lys Lys Pro Val His Glu Lys Lys Arg Ser
 145                 150                 155                 160
 Phe Cys Asn Phe Ile Leu Pro Phe Lys Phe Asp Thr Lys Tyr
                 165                 170                



      <210> 579
      <211> 238
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(234)
      <223> Xaa = any amino acid or nothing 


      <400> 579
 Pro Ala Ser Pro His Leu Pro His Arg Leu Ala Leu Pro Gly Ala Pro
   1               5                  10                  15    
 Ala Pro Asp Ser Pro Ser Pro Pro Leu Pro Gly Gly Val Ala Ala Ala
              20                  25                  30        
 Gly Pro Pro Arg Arg Arg Pro Glu Gln Gln Gln Gln Gln Gln Glu Pro
          35                  40                  45            
 Ala Ser Met Met Lys Phe Lys Pro Asn Gln Thr Arg Thr Tyr Asp Arg
      50                  55                  60                
 Glu Gly Phe Lys Lys Arg Ala Ala Cys Leu Cys Phe Arg Ser Glu Gln
  65                  70                  75                  80
 Glu Asp Glu Val Leu Leu Val Ser Ser Ser Arg Tyr Pro Asp Gln Trp
                  85                  90                  95    
 Ile Val Pro Gly Gly Gly Met Glu Pro Glu Glu Glu Leu Gly Arg Cys
             100                 105                 110        
 Cys Arg Arg Gly Lys Phe Met Lys Glu Ala Gly Ser Gln Arg Lys Thr
         115                 120                 125            
 Xaa Ala Asp Phe Leu Gly Ile Phe Glu Gln Asn Gln Asp Arg Lys His
     130                 135                 140                
 Arg Thr Tyr Trp Tyr Ser Val Leu Pro Val Thr Glu Ile Leu Glu Asp
 145                 150                 155                 160
 Trp Glu Asp Ser Val Asn Ile Gly Arg Lys Arg Glu Trp Phe Lys Val
                 165                 170                 175    
 Glu Asp Ala Ile Lys Val Leu Gln Cys His Lys Pro Val His Ala Glu
             180                 185                 190        
 Tyr Leu Glu Lys Leu Lys Leu Gly Cys Ser Pro Ala Asn Gly Asn Ser
         195                 200                 205            
 Thr Val Pro Ser Leu Pro Asp Asn Asn Ala Leu Phe Val Thr Ala Ala
     210                 215                 220                
 Gln Thr Ser Gly Leu Pro Ser Ser Val Arg
 225                 230                



      <210> 580
      <211> 295
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(284)
      <223> Xaa = any amino acid or nothing 


      <400> 580
 Thr Ala Ser Thr Leu Arg Cys Arg Leu Ser Gln Ala Cys Val Arg Val
   1               5                  10                  15    
 Ser Ala Ala Ala Gly Pro Ala Pro Thr Arg Lys Asp Leu Thr Ala Ala
              20                  25                  30        
 Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala
          35                  40                  45            
 Arg Glu Cys Pro Thr Gly Gly Gly Arg Arg Arg Gly Ile Arg Ser Arg
      50                  55                  60                
 Arg Arg Gly Trp Phe Tyr Leu Gly Arg Gly Phe Gln Phe Val Ser Ser
  65                  70                  75                  80
 Ser Leu Pro Asp Ile Cys Tyr Arg Cys Gly Glu Val Trp Val Ile Phe
                  85                  90                  95    
 Ala Lys Asp Ser Xaa Ile Phe Lys Glu Asp Glu Ala Cys Leu Leu Thr
             100                 105                 110        
 Cys Gly Arg Gly Gly His Ile Cys Gln Gly Ile Ser Lys Glu Pro Lys
         115                 120                 125            
 Lys Lys Ser Glu Thr Asn Cys Cys Tyr Asn Cys Gly Lys Pro Gly His
     130                 135                 140                
 Leu Ala Arg Asp Cys Asp His Ala Asp Asp Leu Lys Cys Tyr Ser Cys
 145                 150                 155                 160
 Gly Glu Phe Gly His Ile Gln Lys Asp Cys Thr Lys Val Lys Cys Tyr
                 165                 170                 175    
 Arg Cys Gly Glu Thr Gly His Val Ala Ile Asn Cys Ser Lys Thr Ser
             180                 185                 190        
 Glu Val Asn Cys Tyr Arg Cys Gly Glu Ser Gly His Leu Ala Arg Glu
         195                 200                 205            
 Cys Thr Ile Glu Ala Thr Ala Leu Ile Asn Phe Pro Leu Ser Pro Leu
     210                 215                 220                
 Leu Phe Leu Ile Asp Gly Cys Ile Ile Phe Ser Glu Ser Ser Ser Leu
 225                 230                 235                 240
 Ala Lys Gly Trp Pro Asp Arg Gly Asn Ser Gln Ala Ser Glu Leu Tyr
                 245                 250                 255    
 Leu Pro Cys Lys Arg Arg Lys Gly Val Glu Lys Lys Ile Asp Phe Leu
             260                 265                 270        
 His Leu Thr Thr Lys Lys Ser Leu Cys Leu Val Trp
         275                 280                



      <210> 581
      <211> 295
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(284)
      <223> Xaa = any amino acid or nothing 


      <400> 581
 Thr Ala Ser Thr Leu Arg Cys Arg Leu Ser Gln Ala Cys Val Arg Val
   1               5                  10                  15    
 Ser Ala Ala Ala Gly Pro Ala Pro Thr Arg Lys Asp Leu Thr Ala Ala
              20                  25                  30        
 Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala
          35                  40                  45            
 Arg Glu Cys Pro Thr Gly Gly Gly Arg Arg Arg Gly Ile Arg Ser Arg
      50                  55                  60                
 Arg Arg Gly Trp Phe Tyr Leu Gly Arg Gly Phe Gln Phe Val Ser Ser
  65                  70                  75                  80
 Ser Leu Pro Asp Ile Cys Tyr Arg Cys Gly Glu Val Trp Val Ile Phe
                  85                  90                  95    
 Ala Lys Asp Ser Xaa Ile Phe Lys Glu Asp Glu Ala Cys Leu Leu Thr
             100                 105                 110        
 Cys Gly Arg Gly Gly His Ile Cys Gln Gly Ile Ser Lys Glu Pro Lys
         115                 120                 125            
 Lys Lys Ser Glu Thr Asn Cys Cys Tyr Asn Cys Gly Lys Pro Gly His
     130                 135                 140                
 Leu Ala Arg Asp Cys Asp His Ala Asp Asp Leu Lys Cys Tyr Ser Cys
 145                 150                 155                 160
 Gly Glu Phe Gly His Ile Gln Lys Asp Cys Thr Lys Val Lys Cys Tyr
                 165                 170                 175    
 Arg Cys Gly Glu Thr Gly His Val Ala Ile Asn Cys Ser Lys Thr Ser
             180                 185                 190        
 Glu Val Asn Cys Tyr Arg Cys Gly Glu Ser Gly His Leu Ala Arg Glu
         195                 200                 205            
 Cys Thr Ile Glu Ala Thr Ala Leu Ile Asn Phe Pro Leu Ser Pro Leu
     210                 215                 220                
 Leu Phe Leu Ile Asp Gly Cys Ile Ile Phe Ser Glu Ser Ser Ser Leu
 225                 230                 235                 240
 Ala Lys Gly Trp Pro Asp Arg Gly Asn Ser Gln Ala Ser Glu Leu Tyr
                 245                 250                 255    
 Leu Pro Cys Lys Arg Arg Lys Gly Val Glu Lys Lys Ile Asp Phe Leu
             260                 265                 270        
 His Leu Thr Thr Lys Lys Ser Leu Cys Leu Val Trp
         275                 280                



      <210> 582
      <211> 318
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(305)
      <223> Xaa = any amino acid or nothing 


      <400> 582
 Ala Gly Trp Arg Gly Phe Gln Ser Asp Cys Ala Gly Arg Gly Gly Leu
   1               5                  10                  15    
 Val His Pro Gly Thr Arg Pro Gly Gly Ser Val Leu Ser Ser Gly Arg
              20                  25                  30        
 Val Asp Pro Phe Ser Arg Lys Asp Trp Tyr Asp Val Lys Ala Pro Ala
          35                  40                  45            
 Met Phe Asn Ile Arg Asn Ile Gly Lys Thr Leu Arg His Gln Gly Pro
      50                  55                  60                
 Lys Glu Pro Asn Phe Ala Ser Asp Gly Leu Lys Gly Arg Val Phe Xaa
  65                  70                  75                  80
 Ser Glu Ser Leu Leu Asp Leu Gln Asn Asp Glu Val Ala Phe Xaa Glu
                  85                  90                  95    
 Asn Ser Lys Leu Asp Leu Leu Glu Asp Cys Ser Arg Gly Lys Asn Leu
             100                 105                 110        
 Pro Xaa Leu Asn Phe Pro Met Gly His Trp Asp Pro Leu Pro Arg Asp
         115                 120                 125            
 Gln Lys Cys Val Ser Met Gly Pro Lys Lys Trp Pro Asp Gln Xaa Leu
     130                 135                 140                
 Glu Ala Pro Arg Leu Met Val Gln Asp Leu Pro Asp Gly Leu Leu Cys
 145                 150                 155                 160
 Phe Arg Leu Val Leu Val Val Trp Val Leu Leu Lys Lys Arg Gln Gln
                 165                 170                 175    
 Ser Arg Leu Arg Lys Asp Leu Phe Met Ala Ser Gly Thr Pro Thr Gly
             180                 185                 190        
 Ser Arg Gln Asn Pro Gly Arg Lys Met Asp Gly Lys Ser Met Thr Pro
         195                 200                 205            
 Glu Arg Trp Gln Asp Gln Met Asp Leu Glu Arg Lys Trp Phe His Lys
     210                 215                 220                
 Leu Ile Pro Arg Gln His Leu Glu Lys Asp Leu Glu Lys Ala Cys Pro
 225                 230                 235                 240
 Ile Leu Phe Ile Leu Phe His Asp Val Phe Val Arg Lys Ser Lys Asn
                 245                 250                 255    
 Ala Glu Lys Thr Pro Ser Phe Glu Leu Gly Lys Leu Met Glu Leu His
             260                 265                 270        
 Gly Xaa Gly Ser Arg Ser Gly Lys Ala Pro Gly Asp Glu Thr Gly Ala
         275                 280                 285            
 Lys Arg Xaa Thr Glu Leu His Gly Tyr Glu Pro Pro Val Gln Glu Ser
     290                 295                 300                
 Val
 305



      <210> 583
      <211> 246
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(241)
      <223> Xaa = any amino acid or nothing 


      <400> 583
 Gly Trp Phe Leu Met Gly Leu Ala Ser Glu Ser Ser Thr Pro Cys Pro
   1               5                  10                  15    
 Phe Pro Gly Glu Ala Lys Met His Thr Leu Pro Pro Phe Pro Ser Cys
              20                  25                  30        
 Pro Val Tyr Arg Thr Ile Ala Gly Glu Lys Gly Lys Gly Xaa Ser Cys
          35                  40                  45            
 Leu Ser Leu Gln Asp Cys Val Ala Asp Met Leu Thr Ala Asp Asp Ser
      50                  55                  60                
 Gly Leu Leu Cys Val Trp Arg Ser Gly Pro Glu Phe Thr Leu Leu Thr
  65                  70                  75                  80
 Arg Ile Pro Gly Phe Gly Xaa Val Arg Gln Lys Gly Xaa Arg Ala Ser
                  85                  90                  95    
 Xaa Asp Ser Phe Arg Leu Gly Ser Arg Ile Xaa Ser Gly Gln Asn Lys
             100                 105                 110        
 Val Gly Cys His Pro Cys Arg Val Pro Cys Pro Ser Val Gln Leu Trp
         115                 120                 125            
 Gln Gly Ile Ile Ala Ala Gly Tyr Gly Asn Gly Gln Val His Leu Tyr
     130                 135                 140                
 Glu Ala Thr Thr Gly Asn Leu His Val Gln Ile Asn Ala His Ala Arg
 145                 150                 155                 160
 Ala Ile Cys Ala Leu Asp Leu Ala Ser Glu Val Gly Lys Leu Leu Ser
                 165                 170                 175    
 Ala Gly Glu Asp Thr Phe Val His Ile Trp Lys Leu Ser Arg Asn Pro
             180                 185                 190        
 Glu Ser Gly His Ile Glu Val Glu Pro Cys His Gly Glu Cys Val Ala
         195                 200                 205            
 Asp Thr Gln Leu Cys Gly Ala Arg Phe Cys Asp Ser Gln Gly Asn Ser
     210                 215                 220                
 Phe Ala Val Thr Gly Tyr Asp Leu Ala Glu Ile Arg Arg Phe Ser Ser
 225                 230                 235                 240
 Val
    



      <210> 584
      <211> 246
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(241)
      <223> Xaa = any amino acid or nothing 


      <400> 584
 Gly Trp Phe Leu Met Gly Leu Ala Ser Glu Ser Ser Thr Pro Cys Pro
   1               5                  10                  15    
 Phe Pro Gly Glu Ala Lys Met His Thr Leu Pro Pro Phe Pro Ser Cys
              20                  25                  30        
 Pro Val Tyr Arg Thr Ile Ala Gly Glu Lys Gly Lys Gly Xaa Ser Cys
          35                  40                  45            
 Leu Ser Leu Gln Asp Cys Val Ala Asp Met Leu Thr Ala Asp Asp Ser
      50                  55                  60                
 Gly Leu Leu Cys Val Trp Arg Ser Gly Pro Glu Phe Thr Leu Leu Thr
  65                  70                  75                  80
 Arg Ile Pro Gly Phe Gly Xaa Val Arg Gln Lys Gly Xaa Arg Ala Ser
                  85                  90                  95    
 Xaa Asp Ser Phe Arg Leu Gly Ser Arg Ile Xaa Ser Gly Gln Asn Lys
             100                 105                 110        
 Val Gly Cys His Pro Cys Arg Val Pro Cys Pro Ser Val Gln Leu Trp
         115                 120                 125            
 Gln Gly Ile Ile Ala Ala Gly Tyr Gly Asn Gly Gln Val His Leu Tyr
     130                 135                 140                
 Glu Ala Thr Thr Gly Asn Leu His Val Gln Ile Asn Ala His Ala Arg
 145                 150                 155                 160
 Ala Ile Cys Ala Leu Asp Leu Ala Ser Glu Val Gly Lys Leu Leu Ser
                 165                 170                 175    
 Ala Gly Glu Asp Thr Phe Val His Ile Trp Lys Leu Ser Arg Asn Pro
             180                 185                 190        
 Glu Ser Gly His Ile Glu Val Glu Pro Cys His Gly Glu Cys Val Ala
         195                 200                 205            
 Asp Thr Gln Leu Cys Gly Ala Arg Phe Cys Asp Ser Gln Gly Asn Ser
     210                 215                 220                
 Phe Ala Val Thr Gly Tyr Asp Leu Ala Glu Ile Arg Arg Phe Ser Ser
 225                 230                 235                 240
 Val
    



      <210> 585
      <211> 336
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(322)
      <223> Xaa = any amino acid or nothing 


      <400> 585
 Ser Arg Ser Asp Phe Pro Ala Arg Arg Phe Arg Gly Ala Asp Gly Phe
   1               5                  10                  15    
 Pro Ala Leu Ala Cys Cys Leu Glu Glu Lys Leu Ser Leu Cys Phe Arg
              20                  25                  30        
 Pro Ser Asp Pro Gly Ala Glu Pro Pro Arg Thr Ala Val Arg Pro Ile
          35                  40                  45            
 Thr Glu Arg Ser Leu Leu Gln Gly Asp Glu Ile Xaa Asn Ala Leu Thr
      50                  55                  60                
 Asp Asn Tyr Gly Asn Val Met Pro Val Asp Trp Lys Ser Ser His Thr
  65                  70                  75                  80
 Arg Thr Leu His Leu Leu Thr Leu Asn Leu Ser Lys Lys Gly Val Ser
                  85                  90                  95    
 Asp Ser Leu Leu Phe Asp Thr Ser Asp Asp Glu Glu Leu Arg Glu Gln
             100                 105                 110        
 Leu Asp Met His Ser Ile Ile Val Ser Cys Val Arg Ser Glu Pro Leu
         115                 120                 125            
 Phe Thr Ala Asp Gln Val Ile Glu Glu Ile Glu Glu Leu Met Gln Glu
     130                 135                 140                
 Ser Pro Asp Pro Asp Asp Tyr Glu Thr Pro Thr Gln Ser Asp Arg Leu
 145                 150                 155                 160
 Ser Met Leu Ser Gln Glu Ile Gln Thr Leu Lys Lys Ser Ile Thr Gly
                 165                 170                 175    
 Ser Tyr Glu Glu Arg Val Lys Arg Leu Ser Val Ser Glu Leu Asn Glu
             180                 185                 190        
 Ile Leu Glu Glu Thr Glu Thr Ala Ile Lys Glu Tyr Ser Glu Glu Leu
         195                 200                 205            
 Val Gln Gln Leu Ala Leu Arg Asp Glu Leu Xaa Phe Glu Lys Glu Val
     210                 215                 220                
 Lys Asn Ser Phe Ile Ser Val Leu Ile Glu Val Gln Asn Lys Gln Lys
 225                 230                 235                 240
 Glu His Lys Glu Thr Ala Lys Lys Lys Lys Lys Leu Lys Asn Gly Ser
                 245                 250                 255    
 Ser Gln Asn Gly Lys Asn Glu Arg Ser His Met Pro Gly Thr Tyr Leu
             260                 265                 270        
 Thr Thr Val Ile Pro Tyr Glu Lys Lys Asn Gly Pro Pro Ser Val Glu
         275                 280                 285            
 Asp Leu Gln Ile Leu Thr Lys Ile Leu Cys Ala Met Lys Glu Asp Ser
     290                 295                 300                
 Glu Lys Val Pro Ser Leu Leu Thr Asp Tyr Ile Leu Lys Val Leu Cys
 305                 310                 315                 320
 Pro Thr
        



      <210> 586
      <211> 336
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(322)
      <223> Xaa = any amino acid or nothing 


      <400> 586
 Ser Arg Ser Asp Phe Pro Ala Arg Arg Phe Arg Gly Ala Asp Gly Phe
   1               5                  10                  15    
 Pro Ala Leu Ala Cys Cys Leu Glu Glu Lys Leu Ser Leu Cys Phe Arg
              20                  25                  30        
 Pro Ser Asp Pro Gly Ala Glu Pro Pro Arg Thr Ala Val Arg Pro Ile
          35                  40                  45            
 Thr Glu Arg Ser Leu Leu Gln Gly Asp Glu Ile Xaa Asn Ala Leu Thr
      50                  55                  60                
 Asp Asn Tyr Gly Asn Val Met Pro Val Asp Trp Lys Ser Ser His Thr
  65                  70                  75                  80
 Arg Thr Leu His Leu Leu Thr Leu Asn Leu Ser Lys Lys Gly Val Ser
                  85                  90                  95    
 Asp Ser Leu Leu Phe Asp Thr Ser Asp Asp Glu Glu Leu Arg Glu Gln
             100                 105                 110        
 Leu Asp Met His Ser Ile Ile Val Ser Cys Val Arg Ser Glu Pro Leu
         115                 120                 125            
 Phe Thr Ala Asp Gln Val Ile Glu Glu Ile Glu Glu Leu Met Gln Glu
     130                 135                 140                
 Ser Pro Asp Pro Asp Asp Tyr Glu Thr Pro Thr Gln Ser Asp Arg Leu
 145                 150                 155                 160
 Ser Met Leu Ser Gln Glu Ile Gln Thr Leu Lys Lys Ser Ile Thr Gly
                 165                 170                 175    
 Ser Tyr Glu Glu Arg Val Lys Arg Leu Ser Val Ser Glu Leu Asn Glu
             180                 185                 190        
 Ile Leu Glu Glu Thr Glu Thr Ala Ile Lys Glu Tyr Ser Glu Glu Leu
         195                 200                 205            
 Val Gln Gln Leu Ala Leu Arg Asp Glu Leu Xaa Phe Glu Lys Glu Val
     210                 215                 220                
 Lys Asn Ser Phe Ile Ser Val Leu Ile Glu Val Gln Asn Lys Gln Lys
 225                 230                 235                 240
 Glu His Lys Glu Thr Ala Lys Lys Lys Lys Lys Leu Lys Asn Gly Ser
                 245                 250                 255    
 Ser Gln Asn Gly Lys Asn Glu Arg Ser His Met Pro Gly Thr Tyr Leu
             260                 265                 270        
 Thr Thr Val Ile Pro Tyr Glu Lys Lys Asn Gly Pro Pro Ser Val Glu
         275                 280                 285            
 Asp Leu Gln Ile Leu Thr Lys Ile Leu Cys Ala Met Lys Glu Asp Ser
     290                 295                 300                
 Glu Lys Val Pro Ser Leu Leu Thr Asp Tyr Ile Leu Lys Val Leu Cys
 305                 310                 315                 320
 Pro Thr
        



      <210> 587
      <211> 708
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(672)
      <223> Xaa = any amino acid or nothing 


      <400> 587
 Ala Ser Ser His Arg Thr Arg Phe Gly Pro Ser Glu Gln Ser Gly Glu
   1               5                  10                  15    
 Met Leu Leu Pro Leu Leu Leu Leu Leu Pro Met Cys Trp Ala Val Glu
              20                  25                  30        
 Val Lys Arg Pro Arg Cys Val Ser Leu Thr Asn Arg Gly Phe Tyr Asp
          35                  40                  45            
 Glu Ser Lys Pro Phe Thr Cys Leu Asp Gly Ser Ala Thr Ile Pro Phe
      50                  55                  60                
 Asp Gln Val Asn Asp Asp Tyr Cys Asp Cys Lys Asp Gly Ser Xaa Arg
  65                  70                  75                  80
 Ser Gln Ala Thr Ala Ala Cys Pro Xaa Trp Ala Ser Phe Pro Leu Ala
                  85                  90                  95    
 Thr Lys His Leu Gly Tyr Lys Ala Pro Cys Asn Asn Pro Leu Pro Asn
             100                 105                 110        
 Arg Trp Ser Asn Asp Gly Val Cys Asp Cys Cys Asp Gly Thr Asp Glu
         115                 120                 125            
 Tyr Asn Ser Gly Val Ile Cys Glu Asn Thr Cys Lys Glu Glu Gly Pro
     130                 135                 140                
 Val Arg Arg Arg Glu Ser Leu Gln Gln Met Ala Glu Val Thr Arg Glu
 145                 150                 155                 160
 Gly Phe Arg Leu Glu Glu Asp Pro Leu Phe Glu Gly Leu Gly Lys Lys
                 165                 170                 175    
 Ala Arg Glu Glu Lys Gln Lys Lys Leu Ile Glu Leu Gln Ala Gly Lys
             180                 185                 190        
 Lys Ser Leu Glu Asp Gln Val Glu Met Leu Arg Thr Val Lys Glu Glu
         195                 200                 205            
 Ala Glu Lys Pro Glu Arg Glu Ala Lys Glu Gln His Gln Lys Leu Trp
     210                 215                 220                
 Glu Glu Gln Leu Ala Gly Phe Gln Gly Pro Asn Arg Glu Gln Asp Ala
 225                 230                 235                 240
 Arg Ala Ala Asp Ala Phe Lys Glu Leu Asp Asp Asp Met Asp Gly Thr
                 245                 250                 255    
 Val Ser Val Thr Glu Leu Gln Thr His Pro Glu Leu Asp Thr Asp Gly
             260                 265                 270        
 Asp Gly Ala Leu Leu Glu Ala Glu Ala Gln Ala Leu Leu Ser Gly Asp
         275                 280                 285            
 Thr Gln Thr Asp Ala Thr Ser Phe Tyr Asp Arg Val Trp Ala Ala Ile
     290                 295                 300                
 Arg Asp Lys Tyr Arg Ser Glu Ala Leu Pro Thr Asp Leu Pro Thr Pro
 305                 310                 315                 320
 Ser Ala Pro Asp Leu Thr Glu Pro Lys Glu Glu Gln Pro Pro Val Pro
                 325                 330                 335    
 Ser Ser Pro Thr Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
             340                 345                 350        
 Gln Ala Glu Glu Glu Glu Glu Glu Glu Asp Ser Glu Val Gln Gly Glu
         355                 360                 365            
 Gln Pro Lys Glu Ala Pro Pro Pro Leu Ala Pro Pro Gln Pro Gly Arg
     370                 375                 380                
 Pro Ala Glu Glu Asp Lys Met Pro Pro Tyr Asp Glu Gln Thr Gln Ala
 385                 390                 395                 400
 Phe Ile Asp Ala Ala Gln Glu Ala Arg Asn Lys Phe Glu Glu Ala Glu
                 405                 410                 415    
 Arg Ser Leu Lys Asp Met Glu Glu Ser Ile Arg Asn Leu Glu Gln Glu
             420                 425                 430        
 Ile Ser Phe Asp Phe Gly Pro Asn Ala Thr Phe Ala Tyr Leu Tyr Ser
         435                 440                 445            
 Gln Cys Tyr Glu Leu Thr Thr Asn Glu Tyr Val Tyr Arg Leu Cys Pro
     450                 455                 460                
 Phe Lys Leu Val Ser Gln Lys Pro Lys Leu Gly Gly Leu Ser His Gln
 465                 470                 475                 480
 Ala Leu Gly Thr Trp Gly Leu Gln Gly Leu Gly Pro Asp His Gly Gln
                 485                 490                 495    
 Val Ser Val Ala Met Lys Phe Xaa Ala Arg His Gly Ala Cys Trp Gln
             500                 505                 510        
 Gly Pro Asn Arg Ser Ser Thr Val Thr Leu Leu Cys Ser Gly Lys Gly
         515                 520                 525            
 Asn Met Val Thr Ser Thr Thr Glu Pro Ser Gly Cys Glu Tyr Leu His
     530                 535                 540                
 Gly Ser Xaa Xaa Thr Pro Ala Ala Cys Pro Glu Pro Pro Pro Xaa Ser
 545                 550                 555                 560
 Asn Pro Asn Arg Lys Thr Asp His Asp Glu Leu Leu Ala Trp Asp Gly
                 565                 570                 575    
 Arg Lys Arg Thr Phe Lys Glu Gly Met Lys Pro Ser Pro Leu Gln Leu
             580                 585                 590        
 Pro Phe His Pro Pro Pro Leu Gly Leu Ala Cys Gly Phe Leu Leu Pro
         595                 600                 605            
 Ser Ser Val Gly Gly Arg Asp Leu Cys Gly Gly Phe Val Pro Cys Phe
     610                 615                 620                
 Leu Gly Ala Gln Gly Gly Ala Trp Phe His Ile Pro Arg Pro Pro Thr
 625                 630                 635                 640
 Ala Phe Lys Asp Gly Leu Arg Glu Leu Ala Leu Pro Gly Pro Pro His
                 645                 650                 655    
 Leu Gly Asp Ser Pro His His Pro Gln Pro Cys Pro Cys His Pro Ser
             660                 665                 670        





      <210> 588
      <211> 708
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(672)
      <223> Xaa = any amino acid or nothing 


      <400> 588
 Ala Ser Ser His Arg Thr Arg Phe Gly Pro Ser Glu Gln Ser Gly Glu
   1               5                  10                  15    
 Met Leu Leu Pro Leu Leu Leu Leu Leu Pro Met Cys Trp Ala Val Glu
              20                  25                  30        
 Val Lys Arg Pro Arg Cys Val Ser Leu Thr Asn Arg Gly Phe Tyr Asp
          35                  40                  45            
 Glu Ser Lys Pro Phe Thr Cys Leu Asp Gly Ser Ala Thr Ile Pro Phe
      50                  55                  60                
 Asp Gln Val Asn Asp Asp Tyr Cys Asp Cys Lys Asp Gly Ser Xaa Arg
  65                  70                  75                  80
 Ser Gln Ala Thr Ala Ala Cys Pro Xaa Trp Ala Ser Phe Pro Leu Ala
                  85                  90                  95    
 Thr Lys His Leu Gly Tyr Lys Ala Pro Cys Asn Asn Pro Leu Pro Asn
             100                 105                 110        
 Arg Trp Ser Asn Asp Gly Val Cys Asp Cys Cys Asp Gly Thr Asp Glu
         115                 120                 125            
 Tyr Asn Ser Gly Val Ile Cys Glu Asn Thr Cys Lys Glu Glu Gly Pro
     130                 135                 140                
 Val Arg Arg Arg Glu Ser Leu Gln Gln Met Ala Glu Val Thr Arg Glu
 145                 150                 155                 160
 Gly Phe Arg Leu Glu Glu Asp Pro Leu Phe Glu Gly Leu Gly Lys Lys
                 165                 170                 175    
 Ala Arg Glu Glu Lys Gln Lys Lys Leu Ile Glu Leu Gln Ala Gly Lys
             180                 185                 190        
 Lys Ser Leu Glu Asp Gln Val Glu Met Leu Arg Thr Val Lys Glu Glu
         195                 200                 205            
 Ala Glu Lys Pro Glu Arg Glu Ala Lys Glu Gln His Gln Lys Leu Trp
     210                 215                 220                
 Glu Glu Gln Leu Ala Gly Phe Gln Gly Pro Asn Arg Glu Gln Asp Ala
 225                 230                 235                 240
 Arg Ala Ala Asp Ala Phe Lys Glu Leu Asp Asp Asp Met Asp Gly Thr
                 245                 250                 255    
 Val Ser Val Thr Glu Leu Gln Thr His Pro Glu Leu Asp Thr Asp Gly
             260                 265                 270        
 Asp Gly Ala Leu Leu Glu Ala Glu Ala Gln Ala Leu Leu Ser Gly Asp
         275                 280                 285            
 Thr Gln Thr Asp Ala Thr Ser Phe Tyr Asp Arg Val Trp Ala Ala Ile
     290                 295                 300                
 Arg Asp Lys Tyr Arg Ser Glu Ala Leu Pro Thr Asp Leu Pro Thr Pro
 305                 310                 315                 320
 Ser Ala Pro Asp Leu Thr Glu Pro Lys Glu Glu Gln Pro Pro Val Pro
                 325                 330                 335    
 Ser Ser Pro Thr Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
             340                 345                 350        
 Gln Ala Glu Glu Glu Glu Glu Glu Glu Asp Ser Glu Val Gln Gly Glu
         355                 360                 365            
 Gln Pro Lys Glu Ala Pro Pro Pro Leu Ala Pro Pro Gln Pro Gly Arg
     370                 375                 380                
 Pro Ala Glu Glu Asp Lys Met Pro Pro Tyr Asp Glu Gln Thr Gln Ala
 385                 390                 395                 400
 Phe Ile Asp Ala Ala Gln Glu Ala Arg Asn Lys Phe Glu Glu Ala Glu
                 405                 410                 415    
 Arg Ser Leu Lys Asp Met Glu Glu Ser Ile Arg Asn Leu Glu Gln Glu
             420                 425                 430        
 Ile Ser Phe Asp Phe Gly Pro Asn Ala Thr Phe Ala Tyr Leu Tyr Ser
         435                 440                 445            
 Gln Cys Tyr Glu Leu Thr Thr Asn Glu Tyr Val Tyr Arg Leu Cys Pro
     450                 455                 460                
 Phe Lys Leu Val Ser Gln Lys Pro Lys Leu Gly Gly Leu Ser His Gln
 465                 470                 475                 480
 Ala Leu Gly Thr Trp Gly Leu Gln Gly Leu Gly Pro Asp His Gly Gln
                 485                 490                 495    
 Val Ser Val Ala Met Lys Phe Xaa Ala Arg His Gly Ala Cys Trp Gln
             500                 505                 510        
 Gly Pro Asn Arg Ser Ser Thr Val Thr Leu Leu Cys Ser Gly Lys Gly
         515                 520                 525            
 Asn Met Val Thr Ser Thr Thr Glu Pro Ser Gly Cys Glu Tyr Leu His
     530                 535                 540                
 Gly Ser Xaa Xaa Thr Pro Ala Ala Cys Pro Glu Pro Pro Pro Xaa Ser
 545                 550                 555                 560
 Asn Pro Asn Arg Lys Thr Asp His Asp Glu Leu Leu Ala Trp Asp Gly
                 565                 570                 575    
 Arg Lys Arg Thr Phe Lys Glu Gly Met Lys Pro Ser Pro Leu Gln Leu
             580                 585                 590        
 Pro Phe His Pro Pro Pro Leu Gly Leu Ala Cys Gly Phe Leu Leu Pro
         595                 600                 605            
 Ser Ser Val Gly Gly Arg Asp Leu Cys Gly Gly Phe Val Pro Cys Phe
     610                 615                 620                
 Leu Gly Ala Gln Gly Gly Ala Trp Phe His Ile Pro Arg Pro Pro Thr
 625                 630                 635                 640
 Ala Phe Lys Asp Gly Leu Arg Glu Leu Ala Leu Pro Gly Pro Pro His
                 645                 650                 655    
 Leu Gly Asp Ser Pro His His Pro Gln Pro Cys Pro Cys His Pro Ser
             660                 665                 670        





      <210> 589
      <211> 708
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(672)
      <223> Xaa = any amino acid or nothing 


      <400> 589
 Ala Ser Ser His Arg Thr Arg Phe Gly Pro Ser Glu Gln Ser Gly Glu
   1               5                  10                  15    
 Met Leu Leu Pro Leu Leu Leu Leu Leu Pro Met Cys Trp Ala Val Glu
              20                  25                  30        
 Val Lys Arg Pro Arg Cys Val Ser Leu Thr Asn Arg Gly Phe Tyr Asp
          35                  40                  45            
 Glu Ser Lys Pro Phe Thr Cys Leu Asp Gly Ser Ala Thr Ile Pro Phe
      50                  55                  60                
 Asp Gln Val Asn Asp Asp Tyr Cys Asp Cys Lys Asp Gly Ser Xaa Arg
  65                  70                  75                  80
 Ser Gln Ala Thr Ala Ala Cys Pro Xaa Trp Ala Ser Phe Pro Leu Ala
                  85                  90                  95    
 Thr Lys His Leu Gly Tyr Lys Ala Pro Cys Asn Asn Pro Leu Pro Asn
             100                 105                 110        
 Arg Trp Ser Asn Asp Gly Val Cys Asp Cys Cys Asp Gly Thr Asp Glu
         115                 120                 125            
 Tyr Asn Ser Gly Val Ile Cys Glu Asn Thr Cys Lys Glu Glu Gly Pro
     130                 135                 140                
 Val Arg Arg Arg Glu Ser Leu Gln Gln Met Ala Glu Val Thr Arg Glu
 145                 150                 155                 160
 Gly Phe Arg Leu Glu Glu Asp Pro Leu Phe Glu Gly Leu Gly Lys Lys
                 165                 170                 175    
 Ala Arg Glu Glu Lys Gln Lys Lys Leu Ile Glu Leu Gln Ala Gly Lys
             180                 185                 190        
 Lys Ser Leu Glu Asp Gln Val Glu Met Leu Arg Thr Val Lys Glu Glu
         195                 200                 205            
 Ala Glu Lys Pro Glu Arg Glu Ala Lys Glu Gln His Gln Lys Leu Trp
     210                 215                 220                
 Glu Glu Gln Leu Ala Gly Phe Gln Gly Pro Asn Arg Glu Gln Asp Ala
 225                 230                 235                 240
 Arg Ala Ala Asp Ala Phe Lys Glu Leu Asp Asp Asp Met Asp Gly Thr
                 245                 250                 255    
 Val Ser Val Thr Glu Leu Gln Thr His Pro Glu Leu Asp Thr Asp Gly
             260                 265                 270        
 Asp Gly Ala Leu Leu Glu Ala Glu Ala Gln Ala Leu Leu Ser Gly Asp
         275                 280                 285            
 Thr Gln Thr Asp Ala Thr Ser Phe Tyr Asp Arg Val Trp Ala Ala Ile
     290                 295                 300                
 Arg Asp Lys Tyr Arg Ser Glu Ala Leu Pro Thr Asp Leu Pro Thr Pro
 305                 310                 315                 320
 Ser Ala Pro Asp Leu Thr Glu Pro Lys Glu Glu Gln Pro Pro Val Pro
                 325                 330                 335    
 Ser Ser Pro Thr Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
             340                 345                 350        
 Gln Ala Glu Glu Glu Glu Glu Glu Glu Asp Ser Glu Val Gln Gly Glu
         355                 360                 365            
 Gln Pro Lys Glu Ala Pro Pro Pro Leu Ala Pro Pro Gln Pro Gly Arg
     370                 375                 380                
 Pro Ala Glu Glu Asp Lys Met Pro Pro Tyr Asp Glu Gln Thr Gln Ala
 385                 390                 395                 400
 Phe Ile Asp Ala Ala Gln Glu Ala Arg Asn Lys Phe Glu Glu Ala Glu
                 405                 410                 415    
 Arg Ser Leu Lys Asp Met Glu Glu Ser Ile Arg Asn Leu Glu Gln Glu
             420                 425                 430        
 Ile Ser Phe Asp Phe Gly Pro Asn Ala Thr Phe Ala Tyr Leu Tyr Ser
         435                 440                 445            
 Gln Cys Tyr Glu Leu Thr Thr Asn Glu Tyr Val Tyr Arg Leu Cys Pro
     450                 455                 460                
 Phe Lys Leu Val Ser Gln Lys Pro Lys Leu Gly Gly Leu Ser His Gln
 465                 470                 475                 480
 Ala Leu Gly Thr Trp Gly Leu Gln Gly Leu Gly Pro Asp His Gly Gln
                 485                 490                 495    
 Val Ser Val Ala Met Lys Phe Xaa Ala Arg His Gly Ala Cys Trp Gln
             500                 505                 510        
 Gly Pro Asn Arg Ser Ser Thr Val Thr Leu Leu Cys Ser Gly Lys Gly
         515                 520                 525            
 Asn Met Val Thr Ser Thr Thr Glu Pro Ser Gly Cys Glu Tyr Leu His
     530                 535                 540                
 Gly Ser Xaa Xaa Thr Pro Ala Ala Cys Pro Glu Pro Pro Pro Xaa Ser
 545                 550                 555                 560
 Asn Pro Asn Arg Lys Thr Asp His Asp Glu Leu Leu Ala Trp Asp Gly
                 565                 570                 575    
 Arg Lys Arg Thr Phe Lys Glu Gly Met Lys Pro Ser Pro Leu Gln Leu
             580                 585                 590        
 Pro Phe His Pro Pro Pro Leu Gly Leu Ala Cys Gly Phe Leu Leu Pro
         595                 600                 605            
 Ser Ser Val Gly Gly Arg Asp Leu Cys Gly Gly Phe Val Pro Cys Phe
     610                 615                 620                
 Leu Gly Ala Gln Gly Gly Ala Trp Phe His Ile Pro Arg Pro Pro Thr
 625                 630                 635                 640
 Ala Phe Lys Asp Gly Leu Arg Glu Leu Ala Leu Pro Gly Pro Pro His
                 645                 650                 655    
 Leu Gly Asp Ser Pro His His Pro Gln Pro Cys Pro Cys His Pro Ser
             660                 665                 670        





      <210> 590
      <211> 870
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(820)
      <223> Xaa = any amino acid or nothing 


      <400> 590
 Thr Pro Glu Glu Thr Gln Thr His Tyr Gln Pro Thr Glu Glu Glu Glu
   1               5                  10                  15    
 Val Arg Thr Phe Ala Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu
              20                  25                  30        
 Ile Ile Asn Thr Phe Xaa Leu Glu Thr Lys Arg Ser Phe Leu Arg Glu
          35                  40                  45            
 Leu Leu Ser Asn Ser Ser Asp Ala Leu Gly Gln Asn Pro Ser Ile Glu
      50                  55                  60                
 Arg Leu Thr Arg Ser Pro Phe Asn Xaa Thr Ser Gly Lys Arg Ala Cys
  65                  70                  75                  80
 Ile Phe Asn Leu Ile Thr Arg Thr Lys Gln Asp Pro Asn Ser Ser Leu
                  85                  90                  95    
 Phe Val Gly Tyr Leu Gly Leu Gly Ile Asp Pro Arg Leu Asp Leu Ile
             100                 105                 110        
 Asn Xaa Pro Trp Xaa Leu Ser Pro Lys Ser Trp Gly Pro Lys Arg Phe
         115                 120                 125            
 Met Gly Ser Phe Cys Gln Ala Gly Ala Arg Tyr Ser Ser Met Ile Trp
     130                 135                 140                
 Pro Ser Ser Gly Val Gly Phe Tyr Ser Cys Leu Ile Trp Leu His Glu
 145                 150                 155                 160
 Lys Val Thr Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala Trp
                 165                 170                 175    
 Glu Ser Ser Ala Gly Gly Ser Phe Thr Val Arg Thr Asp Thr Gly Xaa
             180                 185                 190        
 Thr Tyr Gly Ser Val Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp
         195                 200                 205            
 Gln Thr Glu Tyr Leu Glu Gly Thr Lys Asn Lys Arg Arg Leu Xaa Lys
     210                 215                 220                
 Lys His Ser Pro Val Leu Leu Gly Tyr Pro Ile Thr Leu Phe Val Glu
 225                 230                 235                 240
 Lys Glu Arg Asp Lys Glu Val Ser Asp Asp Glu Ala Glu Glu Lys Glu
                 245                 250                 255    
 Ser Lys Xaa Glu Arg Lys Arg Glu Glu Lys Thr Lys Glu Ser Glu Ser
             260                 265                 270        
 Pro Thr Leu Glu Met Glu Asp Val Gly Phe Asp Glu Glu Glu Glu Lys
         275                 280                 285            
 Arg Arg Met Cys Val Lys Arg Lys Lys Arg Arg Ile Lys Glu Lys Ser
     290                 295                 300                
 Ile Asp Gln Glu Glu Phe Thr Lys Thr Lys Pro Ile Trp Thr Arg Asn
 305                 310                 315                 320
 Pro Asp Asp Ile Thr Asn Glu Glu Tyr Gly Glu Phe Tyr Lys Ser Leu
                 325                 330                 335    
 Thr Asn Asp Trp Glu Asp His Phe Ala Val Lys His Phe Ser Val Glu
             340                 345                 350        
 Gly Gln Leu Glu Phe Arg Ala Leu Leu Phe Phe Pro Thr Arg Arg Ala
         355                 360                 365            
 Pro Phe Asp Leu Phe Xaa Lys Gln Lys Arg Lys Arg Thr Ile Ser Lys
     370                 375                 380                
 Leu Tyr Val Arg Arg Ser Phe Ser Ser Leu Asp Asn Cys Glu Glu Pro
 385                 390                 395                 400
 Asn Pro Leu Asn Ile Leu Asn Phe Ile Arg Gly Val Val Asp Ser Gly
                 405                 410                 415    
 Gly Ser Pro Leu Xaa Asn Ile Ser Arg Glu Met Leu Gln Gln Lys Pro
             420                 425                 430        
 Lys Phe Xaa Lys Leu Ser Arg Lys Asn Leu Val Ser Lys Lys Cys Leu
         435                 440                 445            
 Glu Leu Phe Thr Glu Leu Ala Glu Asp Lys Glu Asn Tyr Lys Lys Phe
     450                 455                 460                
 Tyr Glu Gln Phe Ser Lys Asn Leu Lys Ala Leu Glu Tyr His Glu Asp
 465                 470                 475                 480
 Ser Gln Asn Arg Lys Glu Ala Phe Pro Glu Leu Leu Arg Tyr Tyr Thr
                 485                 490                 495    
 Ser Ala Ser Gly Asp Glu Met Val Ser Leu Lys Asp Tyr Cys Thr Arg
             500                 505                 510        
 Met Lys Glu Asn Gln Lys His Ile Tyr Tyr Ile Thr Gly Glu Thr Lys
         515                 520                 525            
 Tyr Gln Val Ala Asn Ser Ser Leu Leu Trp Glu Arg Ser Phe Gly Lys
     530                 535                 540                
 His Gly Leu Glu Lys Val Ile Tyr Met Ile Glu Pro Ile Asp Glu Tyr
 545                 550                 555                 560
 Cys Val Pro Gln Leu Lys Glu Phe Glu Gly Lys Thr Leu Val Val Ser
                 565                 570                 575    
 His Gln Arg Arg Ala Trp Glu Leu Pro Glu Asp Glu Glu Glu Lys Lys
             580                 585                 590        
 Lys Gln Glu Glu Lys Lys Thr Lys Phe Glu Asn Leu Cys Lys Ile Met
         595                 600                 605            
 Lys Asp Ile Leu Glu Lys Lys Val Glu Lys Val Val Val Ser Asn Arg
     610                 615                 620                
 Leu Val Thr Ser Pro Cys Leu Tyr Leu Ser Gln Ala His Ile Gly Trp
 625                 630                 635                 640
 Thr Ala Asn Met Glu Arg Ile His Gly Lys Leu Gln Ala Leu Lys Glu
                 645                 650                 655    
 Thr Thr Ser Thr Met Gly Tyr Tyr Met Ala Ser Gln Arg Lys His Arg
             660                 665                 670        
 Gly Ile Lys Pro Leu Thr Leu Ser Ile Ile Glu Thr Leu Arg Gln Lys
         675                 680                 685            
 Ala Glu Ala Leu Asp Lys Asn Asp Lys Ser Val Glu Gly Ile Leu Val
     690                 695                 700                
 Ile Leu Leu Tyr Glu Thr Ala Leu Leu Ser Ser Gly Phe Gln Ser Trp
 705                 710                 715                 720
 Lys Ile Pro Arg His His Ala Xaa Gln Val Ser Tyr Arg Met Ile Lys
                 725                 730                 735    
 Leu Gly Leu Gly Ile Asp Glu Asp Asp Pro Thr Ala Asp Asp Tyr Gln
             740                 745                 750        
 Cys Cys Trp Xaa Leu Met Glu Asn Ala Thr Pro Leu Lys Gly Asp Asp
         755                 760                 765            
 Asp Thr Phe Thr His Gly Lys Glu Val Gly Leu Ile Leu Leu Gly Leu
     770                 775                 780                
 Arg Gly Trp Thr Leu Pro Val Gln Tyr Ser Thr Ile Pro Leu Ile Ile
 785                 790                 795                 800
 Tyr Phe Ser Lys Asp Val Phe Leu Tyr Phe Trp Leu Ile Phe Lys Lys
                 805                 810                 815    
 Ser Val Trp Pro
             820



      <210> 591
      <211> 385
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(358)
      <223> Xaa = any amino acid or nothing 


      <400> 591
 Gly Trp Gly Pro Ile Pro Ser Thr Asp Val Thr Val Leu Ser Pro Gln
   1               5                  10                  15    
 Lys Pro Ile Leu Leu Gln Gly His Glu Arg Ser Ile Thr Gln Ile Lys
              20                  25                  30        
 Tyr Asn Arg Glu Gly Asp Leu Leu Phe Thr Val Ala Lys Asp Pro Ile
          35                  40                  45            
 Val Asn Val Trp Tyr Ser Val Asn Gly Glu Arg Leu Gly Thr Tyr Met
      50                  55                  60                
 Gly His Thr Gly Ala Val Trp Cys Val Asp Ala Asp Trp Asp Thr Lys
  65                  70                  75                  80
 His Val Leu Thr Gly Ser Ala Asp Asn Ser Cys Arg Leu Trp Asp Cys
                  85                  90                  95    
 Glu Thr Gly Lys Ser Ser Trp Ala Leu Leu Lys Thr Asn Ser Ala Phe
             100                 105                 110        
 Arg Thr Cys Gly Phe Asp Phe Trp Gly Ala Thr Phe Ile Met Phe Ser
         115                 120                 125            
 Asn Gly Gln Ser Arg Trp Gly Tyr Gln Cys Phe Val Glu Leu Phe Trp
     130                 135                 140                
 Thr Trp Arg Asp Ser Glu Ala Arg Phe Asp Asn Asn Glu Pro Leu His
 145                 150                 155                 160
 Gly Arg Phe Pro Cys Asn Asp Ser Lys Ile Thr Ser Ala Gly Leu Gly
                 165                 170                 175    
 Thr Pro Trp Gly Arg Cys Ile Ile Ala Gly Pro Trp Arg Val Gly Glu
             180                 185                 190        
 Leu Asn Gln Tyr Ser Ala Lys Ser Gly Glu Val Leu Val Asn Val Lys
         195                 200                 205            
 Glu His Ser Arg Ala Asp Ser Thr Thr Phe Gln Phe Ile Pro Gly Asp
     210                 215                 220                
 Met Asp His Val Leu Leu Thr Arg Val Pro Arg Asp Asn Thr Ala Lys
 225                 230                 235                 240
 Leu Phe Asp Ser Thr Thr Leu Glu His Gln Lys Gly Phe Arg Gly Gln
                 245                 250                 255    
 Asp Gly Arg Pro Thr Gln Ala Gly Pro Leu Pro Gln Leu Met Thr Lys
             260                 265                 270        
 Val Val Leu Gly Gly Gly Gln Glu Ser His Trp Met Leu Thr Thr Thr
         275                 280                 285            
 Ser Thr Gln Gly Phe Gly Lys Phe Xaa Gly Gln Val Ser Phe His Phe
     290                 295                 300                
 Gly Leu Leu Glu Glu Glu Phe Gly Lys Ser Pro Arg Val Thr Phe Gly
 305                 310                 315                 320
 Pro Ile Asn Ser Val Ala Phe His Pro Asp Gly Lys Ser Tyr Ser Lys
                 325                 330                 335    
 Arg Arg Ala Arg Asp Gly Leu Arg Pro Arg Ser Ile Tyr Phe Arg Pro
             340                 345                 350        
 His Gln Tyr Phe Glu Ile
         355            



      <210> 592
      <211> 385
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(358)
      <223> Xaa = any amino acid or nothing 


      <400> 592
 Gly Trp Gly Pro Ile Pro Ser Thr Asp Val Thr Val Leu Ser Pro Gln
   1               5                  10                  15    
 Lys Pro Ile Leu Leu Gln Gly His Glu Arg Ser Ile Thr Gln Ile Lys
              20                  25                  30        
 Tyr Asn Arg Glu Gly Asp Leu Leu Phe Thr Val Ala Lys Asp Pro Ile
          35                  40                  45            
 Val Asn Val Trp Tyr Ser Val Asn Gly Glu Arg Leu Gly Thr Tyr Met
      50                  55                  60                
 Gly His Thr Gly Ala Val Trp Cys Val Asp Ala Asp Trp Asp Thr Lys
  65                  70                  75                  80
 His Val Leu Thr Gly Ser Ala Asp Asn Ser Cys Arg Leu Trp Asp Cys
                  85                  90                  95    
 Glu Thr Gly Lys Ser Ser Trp Ala Leu Leu Lys Thr Asn Ser Ala Phe
             100                 105                 110        
 Arg Thr Cys Gly Phe Asp Phe Trp Gly Ala Thr Phe Ile Met Phe Ser
         115                 120                 125            
 Asn Gly Gln Ser Arg Trp Gly Tyr Gln Cys Phe Val Glu Leu Phe Trp
     130                 135                 140                
 Thr Trp Arg Asp Ser Glu Ala Arg Phe Asp Asn Asn Glu Pro Leu His
 145                 150                 155                 160
 Gly Arg Phe Pro Cys Asn Asp Ser Lys Ile Thr Ser Ala Gly Leu Gly
                 165                 170                 175    
 Thr Pro Trp Gly Arg Cys Ile Ile Ala Gly Pro Trp Arg Val Gly Glu
             180                 185                 190        
 Leu Asn Gln Tyr Ser Ala Lys Ser Gly Glu Val Leu Val Asn Val Lys
         195                 200                 205            
 Glu His Ser Arg Ala Asp Ser Thr Thr Phe Gln Phe Ile Pro Gly Asp
     210                 215                 220                
 Met Asp His Val Leu Leu Thr Arg Val Pro Arg Asp Asn Thr Ala Lys
 225                 230                 235                 240
 Leu Phe Asp Ser Thr Thr Leu Glu His Gln Lys Gly Phe Arg Gly Gln
                 245                 250                 255    
 Asp Gly Arg Pro Thr Gln Ala Gly Pro Leu Pro Gln Leu Met Thr Lys
             260                 265                 270        
 Val Val Leu Gly Gly Gly Gln Glu Ser His Trp Met Leu Thr Thr Thr
         275                 280                 285            
 Ser Thr Gln Gly Phe Gly Lys Phe Xaa Gly Gln Val Ser Phe His Phe
     290                 295                 300                
 Gly Leu Leu Glu Glu Glu Phe Gly Lys Ser Pro Arg Val Thr Phe Gly
 305                 310                 315                 320
 Pro Ile Asn Ser Val Ala Phe His Pro Asp Gly Lys Ser Tyr Ser Lys
                 325                 330                 335    
 Arg Arg Ala Arg Asp Gly Leu Arg Pro Arg Ser Ile Tyr Phe Arg Pro
             340                 345                 350        
 His Gln Tyr Phe Glu Ile
         355            



      <210> 593
      <211> 474
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(445)
      <223> Xaa = any amino acid or nothing 


      <400> 593
 Asn Thr Met Met Thr Leu Ile Glu Lys Thr Asn Glu Glu Arg Lys Thr
   1               5                  10                  15    
 Leu Ala Ser Ala Thr Leu Glu Glu Ala Lys Lys Glu Gly Lys Arg Asp
              20                  25                  30        
 Ala Leu Asn Xaa Asp Gln Gly Asp Ser Glu Thr Lys Leu Lys Glu Leu
          35                  40                  45            
 Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Asp Arg Ser Val
      50                  55                  60                
 Lys Pro Cys Leu Glu Asn Arg Pro Cys Met Lys Phe Tyr Gly Thr Arg
  65                  70                  75                  80
 Ser Ala Glu Ser Gly Ser Gly Leu Val Gly Arg Pro Ala Leu Arg Lys
                  85                  90                  95    
 Phe Leu Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Xaa Pro
             100                 105                 110        
 Ala Phe Asp Ser Leu Leu Glu Asn Asp Arg Gln Lys Thr His Met Leu
         115                 120                 125            
 Asp Val Met Gln Asp His Phe Ser Arg Ala Ser Ser Ile His Arg Arg
     130                 135                 140                
 Ala Leu Ser Arg Asp Arg Phe Leu Ser Pro Gly Lys Pro Gln Gly Leu
 145                 150                 155                 160
 Pro Tyr His Xaa Pro Cys Pro Phe Ser Leu Ala Pro His Arg Arg Pro
                 165                 170                 175    
 His Phe Phe Phe Pro Lys Ser Arg Ile Arg Pro Ala Ala Leu Met Pro
             180                 185                 190        
 Phe Ser Pro Tyr Gly Ala Pro Xaa Thr Phe His Ala Met Phe Gln Pro
         195                 200                 205            
 Phe Leu Gly Asp Gly Leu His Glu Ala Ser Ala Gly Pro Trp Asp Ile
     210                 215                 220                
 His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr Glu Phe Ile Arg
 225                 230                 235                 240
 Glu Gly Asp Asp Asp Arg Asp Cys Cys Ala Gly Glu Ile Arg His Asn
                 245                 250                 255    
 Phe His Gly Ala Ala Leu Arg Met Lys Asp Gln Val Val Thr Lys Cys
             260                 265                 270        
 Arg Glu Asp Leu Val Leu Trp Asp Cys Ser Thr Asn Asn Pro Ser Pro
         275                 280                 285            
 Gly Xaa Ser Leu Arg Ala Gly Ser Ser Asn Gly Ile Pro Ser Arg Val
     290                 295                 300                
 Arg Leu Arg Arg Val Xaa Thr Gly Val Ile Thr Asn Val Ala Trp Leu
 305                 310                 315                 320
 Lys Val Pro Xaa Pro Val Gly Lys Met Val Gln Thr Thr Phe Phe Leu
                 325                 330                 335    
 Cys Trp Glu Gln Leu Lys Arg Ala Ser Phe Asn Trp Val Val Thr Gly
             340                 345                 350        
 Trp Ala Asn Leu Ser Thr Gln Gly Arg Lys Thr Ser Tyr Leu Ser Gly
         355                 360                 365            
 Gly Ser Thr Thr Gly Gly Leu Ser His Thr Ser Glu Leu Arg Asp Val
     370                 375                 380                
 Pro Phe Pro Val Ser Thr Glu Val Val Arg Glu Ser Ser Phe Asp Ser
 385                 390                 395                 400
 Xaa Ser Pro Ile Thr Cys Asp Gly Ser Leu Val Arg Ser Leu Pro Gly
                 405                 410                 415    
 Lys Asn Pro Leu Lys Phe Met Glu Asp Arg Gly Arg Arg Lys Ala Leu
             420                 425                 430        
 Ala Arg Asn Thr Arg Lys Lys Ser Asn Arg Gly Arg Ser
         435                 440                 445



      <210> 594
      <211> 751
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(723)
      <223> Xaa = any amino acid or nothing 


      <400> 594
 Trp Ser Gln Leu Lys Cys Phe Ile Ile Cys Lys Ile Pro His Thr Val
   1               5                  10                  15    
 Ile Arg Ser Gly Cys Leu Ser Pro Pro Pro Leu Ser Ser Ile Ser Glu
              20                  25                  30        
 Asp Phe Pro Glu Glu Val Arg Leu Phe His Leu Val Ser Glu Ser Trp
          35                  40                  45            
 Pro Thr Val Val Cys Gln Thr Gly Thr Arg Gly Phe Ser Leu His Trp
      50                  55                  60                
 Leu Asp Gly Asn Asn Arg Ala Ser Ala Lys Val Ser Asp Ser Ile Ser
  65                  70                  75                  80
 Ala Gln Tyr Pro Val Val Asp His Glu Phe Asp Ala Val Val Val Gly
                  85                  90                  95    
 Ala Gly Gly Ala Gly Leu Arg Ala Ala Phe Gly Leu Ser Glu Ala Glu
             100                 105                 110        
 Phe Asp Thr Ala Cys Val Thr Lys Leu Phe Pro Thr Arg Ser His Thr
         115                 120                 125            
 Leu Val Ala Ala Gln Gly Gly Ile Asn Ala Ala Leu Gly Asn Met Glu
     130                 135                 140                
 Glu Asp Asn Trp Arg Trp Thr Phe Ser Thr Glu His Pro Xaa Arg Val
 145                 150                 155                 160
 Ser Asp Trp Leu Gly Glu Pro Gly Met Pro Ile His Tyr Met Thr Glu
                 165                 170                 175    
 Gln Ala Pro Ala Ala Val Val Glu Leu Glu Asn Tyr Gly Met Pro Phe
             180                 185                 190        
 Ser Arg Thr Glu Asp Gly Lys Ile Tyr Gln Arg Ala Phe Gly Gly Gln
         195                 200                 205            
 Ser Leu Lys Phe Gly Lys Gly Arg Gln Ala His Arg Cys Cys Cys Val
     210                 215                 220                
 Ala Asp Arg Thr Gly His Ser Ile Leu His Thr Leu Tyr Gly Arg Ser
 225                 230                 235                 240
 Leu Arg Tyr Asp Thr Ser Cys Phe Val Glu Tyr Phe Ala Leu Asp Leu
                 245                 250                 255    
 Leu Ile Glu Asn Arg Glu Cys Arg Gly Cys His Trp His Cys Gly Ile
             260                 265                 270        
 Glu Asp Gly Ser Ile His Ser Arg Leu Arg Ala Lys Asn Thr Val Val
         275                 280                 285            
 Ala Thr Gly Gly Tyr Gly Arg Thr Tyr Phe Ser Cys Thr Ser Ala His
     290                 295                 300                
 Thr Ser Thr Gly Asp Gly Thr Ala Ile Asp Pro Pro Gly Ala Gly Leu
 305                 310                 315                 320
 Pro Cys Gln Asp Leu Glu Phe Val Gln Phe His Pro Thr Gly Ile Tyr
                 325                 330                 335    
 Gly Ala Gly Cys Leu Ile Thr Glu Gly Cys Arg Gly Glu Gly Gly Ile
             340                 345                 350        
 Leu Ile Asn Ser Gln Gly Glu Arg Phe Met Glu Arg Tyr Ala Pro Val
         355                 360                 365            
 Ala Lys Asp Leu Ala Ser Arg Asp Val Val Ser Arg Ser Met Thr Leu
     370                 375                 380                
 Glu Ile Pro Arg Arg Glu Glu Ala Phe Gly Pro Glu Lys Asp His Val
 385                 390                 395                 400
 Tyr Leu Gln Leu His His Ile Pro Pro Glu His Leu Ala Ala Arg Leu
                 405                 410                 415    
 Pro Gly Ile Ser Asp Thr Ala Met Ile Phe Gly Gly Val Asp Val Thr
             420                 425                 430        
 Lys Glu Ser Ile Pro Val Leu Pro Ser Val His Tyr Asn Met Gly Gly
         435                 440                 445            
 Phe Ser Leu Asn Tyr Lys Lys Gln Ile Leu Arg His Val Asn Gly Gln
     450                 455                 460                
 Asp Gln Ile Cys Cys Pro Ala Cys Tyr Ala Cys Trp Gly Gly Arg Leu
 465                 470                 475                 480
 Cys Leu Gly Xaa His Gly Ala Asn Arg Leu Gly Ala Asn Ser Leu Leu
                 485                 490                 495    
 Glu Leu Val Val Phe Gly Arg Ala Cys Ala Leu Ser Ile Glu Glu Ser
             500                 505                 510        
 Cys Arg Pro Gly Asp Glu Val Pro Pro Ile Lys Pro Asn Ala Gly Glu
         515                 520                 525            
 Glu Ser Val Met Asn Leu Asp Lys Leu Arg Phe Ala Asp Gly Arg Ser
     530                 535                 540                
 Ile Arg Thr Ser Glu Leu Arg Leu Ser Met Gln Lys Ser Met Gln Asn
 545                 550                 555                 560
 His Ala Ala Val Phe Pro Cys Gly Glu Ala Leu Phe Pro Lys Lys Val
                 565                 570                 575    
 Cys Gly Lys Ile Ser Lys Leu Tyr Gly Asp Leu Lys His Leu Lys Thr
             580                 585                 590        
 Phe Asp Arg Gly Met Val Trp Asn Thr Asp Leu Val Glu Thr Leu Glu
         595                 600                 605            
 Leu Gln Lys Leu Ile Ala Val Cys Ala Ser Arg Pro Phe Tyr Glu Ala
     610                 615                 620                
 Glu Ala Arg Lys Glu Ser Arg Gly Ala His Ala Lys Glu Arg Leu Gln
 625                 630                 635                 640
 Gly Cys Gly Ile Asp Glu Tyr Asp Asn Ser Lys Pro Ile Gln Gly Ala
                 645                 650                 655    
 Thr Gly Arg Ser Pro Phe Glu Glu His Trp Arg Lys His Thr Pro Val
             660                 665                 670        
 Leu Met Trp Asn Val Gly Thr Gly Lys Thr Leu Leu Phe Met Val Thr
         675                 680                 685            
 Leu Gly Tyr Arg Pro Val Ile Asp Lys Asn Phe Xaa Thr Arg Ala Asp
     690                 695                 700                
 Cys Ala Thr Val Pro Ala Ser His Phe Ala Pro Tyr Cys Trp Asp Lys
 705                 710                 715                 720
 Asp Ser Gly
            



      <210> 595
      <211> 211
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(204)
      <223> Xaa = any amino acid or nothing 


      <400> 595
 Pro Leu Ile Pro Val Leu Arg Thr Ser Pro Gly Leu Ala Met Ala Asp
   1               5                  10                  15    
 Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Ser Glu Ala Ser Ser Leu
              20                  25                  30        
 Phe Asp Lys Asp Gly Asp Gly Thr Ile His His Gln Gly Ser Trp Gly
          35                  40                  45            
 Gln Val Met Arg Ser Leu Arg Gln Ser Pro Thr Asp Ala Glu Leu Gln
      50                  55                  60                
 Asp Met Ile Asn Glu Val Asp Ala Asp Asp Leu Pro Gly Asn Gly Thr
  65                  70                  75                  80
 Ile Asp Phe Pro Glu Phe Leu Asp His Glu Trp Pro Gly Lys Met Lys
                  85                  90                  95    
 Gly Pro Arg Gln Xaa Gly Arg Arg Ser Glu Lys Ala Val Pro Cys His
             100                 105                 110        
 Phe Asp Gln Asp Gly Asn Gly Leu Gln Ser Ser Ala Ala Glu Leu Arg
         115                 120                 125            
 His Val Met Thr Asn Leu Gly Glu Lys Leu Asp Arg Leu Arg Arg Trp
     130                 135                 140                
 Asp Glu Met Ile Arg Glu Ala Asp Ile Asp Gly Asp Gly Gln Val Asn
 145                 150                 155                 160
 Tyr Glu Glu Phe Val Gln Met Met Thr Ala Asn Trp Thr Ala Pro Arg
                 165                 170                 175    
 Ala Pro Cys Asp Ala Arg Ser Leu Asp Leu Ser Leu Pro Arg Ala Arg
             180                 185                 190        
 Thr Leu Ser Ser Thr Leu Pro Ser Val Pro Arg Phe
         195                 200                



      <210> 596
      <211> 347
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(346)
      <223> Xaa = any amino acid or nothing 


      <400> 596
 Leu Ser Trp Lys Lys Glu Glu Glu Gly Arg Gly Gly Glu Gly Gly Gly
   1               5                  10                  15    
 Gly Gly Arg Trp Arg Pro Arg Gly Gly Gly Ile Met Ser Arg Arg Gly
              20                  25                  30        
 Met Glu Arg Thr Thr Leu Leu Gly Gly Met Ala Leu Leu Leu Leu Gln
          35                  40                  45            
 Ala Leu Pro Ser Pro Leu Ser Ala Arg Ala Glu Pro Pro Gln Asp Lys
      50                  55                  60                
 Glu Ala Cys Val Gly Thr Asn Asn Gln Ser Tyr Ile Cys Asp Thr Gly
  65                  70                  75                  80
 His Cys Cys Gly Gln Ser Gln Cys Cys Asn Tyr Tyr Tyr Glu Leu Trp
                  85                  90                  95    
 Arg Phe Trp Leu Ala Trp Thr Ile Ile Ile Ile Leu Ser Cys Cys Cys
             100                 105                 110        
 Val Arg His His Arg Arg Ala Lys His Arg Leu Gln Ala Gln Pro Arg
         115                 120                 125            
 Leu His Glu Ile Asn Leu Ile Ala Tyr Arg Glu Ala His Asn Tyr Ser
     130                 135                 140                
 Ala Leu Pro Phe Tyr Phe Arg Phe Leu Pro Asn Tyr Leu Leu Pro Pro
 145                 150                 155                 160
 Tyr Glu Glu Gly Val Asn Arg Thr Pro Thr Pro Pro Pro Pro Tyr Ser
                 165                 170                 175    
 Ala Phe Gln Leu Gln Gln Gln Gln Leu Leu Pro Pro Gln Cys Gly Pro
             180                 185                 190        
 Ala Gly Gly Ser Pro Pro Gly Ile Asp Pro Thr Arg Gly Ser Gln Gly
         195                 200                 205            
 Ala Gln Ser Ser Pro Leu Ser Glu Pro Ser Arg Ser Ser Thr Arg Pro
     210                 215                 220                
 Pro Ser Ile Ala Asp Pro Asp Pro Ser Asp Leu Pro Val Asp Arg Ala
 225                 230                 235                 240
 Ala Thr Lys Ala Pro Gly Met Glu Pro Ser Gly Ser Val Ala Gly Leu
                 245                 250                 255    
 Gly Glu Leu Asp Pro Gly Ala Phe Leu Asp Lys Asp Ala Glu Cys Arg
             260                 265                 270        
 Glu Glu Leu Leu Lys Asp Asp Ser Ser Glu His Gly Ala Pro Asp Ser
         275                 280                 285            
 Lys Glu Lys Thr Pro Gly Arg His Arg Arg Phe Thr Gly Asp Ser Gly
     290                 295                 300                
 Ile Glu Val Cys Val Cys Asn Arg Gly His His Asp Asp Asp Leu Lys
 305                 310                 315                 320
 Glu Val Gln His Thr His Arg Xaa Cys Ser Gly Trp Ala Pro Gly Leu
                 325                 330                 335    
 Leu Arg Gln Leu Pro Cys Ala Ala Pro Trp
             340                 345    



      <210> 597
      <211> 386
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(371)
      <223> Xaa = any amino acid or nothing 


      <400> 597
 Pro Pro Pro Thr Ala Ala Gly Gly Pro Ser Pro Arg Trp Arg Ala Met
   1               5                  10                  15    
 Arg Pro Ser Gln Arg Arg Pro Pro Thr Leu Pro Met Ala Ala Ser Pro
              20                  25                  30        
 Ala His Trp Pro Arg Glu Ser Leu Val Leu Tyr His Trp Thr Gln Ser
          35                  40                  45            
 Phe Ser Ser Gln Lys Val Arg Leu Val Ile Ala Glu Lys Gly Leu Val
      50                  55                  60                
 Cys Glu Glu Arg Asp Val Ser Leu Pro Gln Ser Glu His Asn Glu Met
  65                  70                  75                  80
 Pro Trp Phe Met Arg Leu Asn Leu Gly Arg Gly Glu Leu Pro Val His
                  85                  90                  95    
 Ser Phe His Arg Asp Asn Ile Ile Gln Cys Tyr Xaa Thr Ser Ser Phe
             100                 105                 110        
 Asp Tyr Val Glu Arg Thr Phe His Arg Glu Arg His Val Val Ala Leu
         115                 120                 125            
 Met Pro Glu Val Gly Ser Arg Ala Ala Pro Arg Val Leu Gln Tyr Arg
     130                 135                 140                
 Glu Leu Leu Asp Ala Leu Pro Met Asp Ala Tyr Thr His Gly Cys Ile
 145                 150                 155                 160
 Leu His Pro Glu Leu Thr Thr Asp Ser Met Ile Pro Lys Tyr Ala Thr
                 165                 170                 175    
 Ala Glu Ile Arg Ser Asp Ile Xaa Pro Asn Ala Thr Thr Asp Leu Met
             180                 185                 190        
 Lys Leu Asp His Glu Glu Glu Pro Gln Leu Ser Glu Pro Tyr Leu Ser
         195                 200                 205            
 Lys Gln Lys Lys Leu Met Ala Lys Ile Leu Glu His Asp Asp Val Ser
     210                 215                 220                
 Tyr Leu Lys Lys Ile Leu Gly Glu Leu Ala Met Val Leu Asp Gln Ile
 225                 230                 235                 240
 Glu Gly Gly Ala Gly Arg Lys Arg Lys Leu Glu Asn Glu Gly Gln Lys
                 245                 250                 255    
 Cys Glu Leu Trp Leu Cys Gly Cys Ala Leu Lys Pro Ser Leu Asn Val
             260                 265                 270        
 Pro Pro Trp Glu Pro Pro Leu His Arg Leu Lys Phe Leu Gly Leu Ser
         275                 280                 285            
 Arg Arg Asn Thr Gly Lys Asp Gly Ser Arg Pro Asn Leu Gln Ser Phe
     290                 295                 300                
 Phe Glu Arg Val Gln Arg Arg Phe Ala Phe Arg Lys Val Leu Gly Asp
 305                 310                 315                 320
 Ile His Thr Thr Leu Leu Ser Ala Val Ile Pro Asn Ala Phe Arg Leu
                 325                 330                 335    
 Val Lys Arg Lys Pro Pro Ser Phe Phe Gly Ala Ser Phe Leu Met Gly
             340                 345                 350        
 Ser Leu Gly Gly Met Gly Tyr Phe Ala Leu His Gly Thr Ser Arg Lys
         355                 360                 365            
 Lys Tyr Ile
     370    



      <210> 598
      <211> 487
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(463)
      <223> Xaa = any amino acid or nothing 


      <400> 598
 Leu Arg Arg Trp Glu Met Leu Ala Arg Ala Ala Arg Gly Thr Gly Ala
   1               5                  10                  15    
 Leu Leu Leu Arg Val Arg Ala Arg Gln Pro Phe Gln Arg Val Arg Thr
              20                  25                  30        
 Glu Ile Thr Trp Val Leu Arg Trp Lys Arg Ala Lys Phe Gln Leu Leu
          35                  40                  45            
 Glu Arg Thr Gly Val Arg Gly His Gly Pro His Val Ile Leu Gln Arg
      50                  55                  60                
 Ile Leu Glu Gly Arg Gly Leu Trp Arg Cys Leu Gln Asp Arg Gly Ala
  65                  70                  75                  80
 Ala Cys Leu Ala Arg Trp Asp Leu Cys Ser Pro Ser Ser Phe Leu Gln
                  85                  90                  95    
 Gly Ser Leu Leu Ala Ser Gly Arg Ala Pro Arg Arg Ala Ser Ser Gly
             100                 105                 110        
 Leu Pro Arg Asn Thr Val Val Leu Phe Val Pro Gln Gln Glu Ala Trp
         115                 120                 125            
 Val Val Glu Arg Met Gly Arg Phe His Arg Ile Leu Glu Pro Gly Leu
     130                 135                 140                
 Asn Ile Leu Ile Pro Val Leu Asp Arg Ile Arg Tyr Val Ala Glu Ser
 145                 150                 155                 160
 Ser Lys Glu Ile Cys Ser Phe Asn Val Ala Leu Ser Asn Ser Ala Val
                 165                 170                 175    
 Thr Leu Asp Asn Val Thr Leu Gln Ile Asp Gly Val Leu Tyr Leu Arg
             180                 185                 190        
 Ile Met Asp Pro Tyr Lys Gly Lys Pro Thr Gly Val Glu Asp Pro Glu
         195                 200                 205            
 Tyr Ala Val Thr Gln Pro Ser Ser Thr Asn His Val Asp Gln Ser Leu
     210                 215                 220                
 Gly Lys Phe Ser Leu Asp Lys Val Phe Arg Glu Arg Glu Ser Leu Asn
 225                 230                 235                 240
 Ala Ser Ile Val Asp Ala Ile Asn Gln Ala Ala Asp Cys Trp Gly Ile
                 245                 250                 255    
 Arg Cys Leu Arg Tyr Glu Ile Lys Asp Ile His Val Pro Pro Arg Val
             260                 265                 270        
 Lys Glu Val Xaa Ala Gly Met His Gly Gly Gly Gln Thr Gly Gly Lys
         275                 280                 285            
 Arg Ala Thr Val Leu Glu Ser Glu Gly Asp Pro Thr Lys Ser Ala Ser
     290                 295                 300                
 Gln Leu Trp Gln Glu Gly Lys Lys Gln Ala Gln Ile Leu Ala Ser Glu
 305                 310                 315                 320
 Ala Glu Lys Ala Glu Gln Ile Asn Ser Gly Gln Gln Glu Arg Ala Ser
                 325                 330                 335    
 Cys Ser Ser Gly Glu Arg Pro Arg Pro Lys Leu Leu Lys Ala Ile Arg
             340                 345                 350        
 Phe Arg Gly Leu Gln Ala Leu Asp Pro Lys His Asn Trp Glu Ile Ala
         355                 360                 365            
 Ala Ala Phe Thr Xaa Leu Val Ala Glu Ala Val Met Phe Ser Gly Val
     370                 375                 380                
 Phe Pro Lys Leu Gly Pro Arg Asn Ser Gln Asn Thr Ile Pro Thr Ala
 385                 390                 395                 400
 Leu Pro Thr Pro Gly Asp Val Thr Ser Met Val Ala Ala Gly Pro Trp
                 405                 410                 415    
 Val Xaa Tyr Gly Ala Leu Thr Gln Ser Pro Ser Pro Ser Ala Arg Asp
             420                 425                 430        
 Phe Gln Thr His Ser Ser Ser Gly Ser Ser Arg Asp Val Gln Gly Thr
         435                 440                 445            
 Asp Ala Ser Pro Xaa Xaa Gly Asn Leu Ile Arg Val Lys Met Ser
     450                 455                 460            



      <210> 599
      <211> 268
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(253)
      <223> Xaa = any amino acid or nothing 


      <400> 599
 Ser Leu Gly Val Ser Thr Arg Ala Gln Gln Ser Leu Pro Thr Val Val
   1               5                  10                  15    
 Leu Cys Gln Trp Cys Tyr Lys Lys Thr Ser Val Arg Ser Gln Asp Pro
              20                  25                  30        
 Gly Gln Arg Arg Val Leu Asp Arg Ala Ala Arg Gln Arg Arg Ile Asn
          35                  40                  45            
 Arg Gln Leu Glu Ala Leu Glu Asn Asp Asn Phe Gln Asp Asp Pro His
      50                  55                  60                
 Ala Gly Leu Pro Gln Leu Gly Lys Arg Leu Pro Gln Phe Asp Asp Asp
  65                  70                  75                  80
 Ala Asp Thr Gly Lys Lys Lys Lys Lys Thr Arg Gly Asp His Phe Lys
                  85                  90                  95    
 Leu Arg Phe Pro Lys Lys Thr Phe Gln Gly Pro Leu Leu Glu Glu Gln
             100                 105                 110        
 Asn Leu Ser Phe Gly Arg Gly Pro Xaa Leu Thr Xaa Arg Pro Cys Ala
         115                 120                 125            
 Gly Pro Pro Ser Arg Gly Pro Gln Arg Pro Phe Cys Ala Val Cys Gly
     130                 135                 140                
 Phe Pro His Pro Pro Tyr Thr Cys Val Ser Cys Gly Ala Arg Tyr Cys
 145                 150                 155                 160
 Thr Val Arg Cys Leu Gly Thr His Gln Glu Thr Arg Cys Leu Lys Val
                 165                 170                 175    
 Asp Leu Cys Lys Pro Gly His Ser Gln Arg Gly Arg Ala Ala Val Ala
             180                 185                 190        
 Leu Pro Gly Leu Ser Glu Arg Gln Asn Phe His His Pro Ile Ala Gly
         195                 200                 205            
 Gly Ser Phe Phe Trp Asp Gln Gly Arg Glu Pro Leu Ile His Pro Thr
     210                 215                 220                
 Lys Leu Cys Leu Ile Cys Gln Glu Arg Pro Ala Ser Leu Leu Gly Thr
 225                 230                 235                 240
 Val Trp Gln Val Gly Trp Ala Pro Thr Val Leu Leu Glu
                 245                 250            



      <210> 600
      <211> 216
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(200)
      <223> Xaa = any amino acid or nothing 


      <400> 600
 Ser Ser Arg Trp Pro Asn Trp Gly Gly Gly Ala Lys Met Cys Gly Ala
   1               5                  10                  15    
 Cys Xaa Lys Thr Val Tyr His Ala Glu Glu Ile Gln Cys Asn Gly Arg
              20                  25                  30        
 Ser Phe His Lys Thr Cys Phe His Cys Met Ala Phe Arg Lys Ala Leu
          35                  40                  45            
 Asp Asn Thr Thr Val Ala Ala His Glu Ser Glu Ile Tyr Cys Lys Val
      50                  55                  60                
 Cys Tyr Gly Arg Arg Tyr Gly Pro Lys Gly Ile Gly Tyr Xaa Gln Gly
  65                  70                  75                  80
 Ala Cys Cys Leu Ser Thr Asp Thr Gly Glu His Leu Gly Leu Gln Phe
                  85                  90                  95    
 Gln Gln Val Pro Lys Gly Arg His Ala Ser Val Thr Thr Ser Asn Pro
             100                 105                 110        
 Ser Lys Phe Thr Ala Lys Phe Gly Glu Ser Glu Lys Cys Pro Arg Cys
         115                 120                 125            
 Gly Lys Ser Val Tyr Ala Ala Glu Lys Val Met Gly Gly Gly Lys Pro
     130                 135                 140                
 Trp Gln Gln Asp Pro Val Phe Arg Cys Ala Ile Cys Gly Lys Ser Leu
 145                 150                 155                 160
 Glu Ser Thr Asn Val Thr Asp Lys Asp Gly Glu Leu Tyr Cys Lys Val
                 165                 170                 175    
 Cys Tyr Ala Lys Asn Phe Gly Pro Thr Gly Ile Gly Phe Gly Gly Leu
             180                 185                 190        
 Thr Gln Gln Val Glu Lys Lys Glu
         195                 200



      <210> 601
      <211> 289
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(278)
      <223> Xaa = any amino acid or nothing 


      <400> 601
 Arg Met Phe His Gly Ile Pro Ala Thr Pro Gly Ile Gly Ala Pro Gly
   1               5                  10                  15    
 Asn Lys Pro Glu Leu Tyr Glu Gly Glu Trp Trp Val Pro Thr Arg Pro
              20                  25                  30        
 Ala Leu Ala Asn Ser Lys Cys Leu Cys Gly Leu Thr Arg Val Leu Gln
          35                  40                  45            
 Pro Leu Leu Ala Leu Ala His Arg Ala Arg Ser Leu Arg Gln Glu Val
      50                  55                  60                
 Lys Leu Tyr Lys Asn Ala Arg Glu Arg Glu Lys Tyr Asp Asn Met Ala
  65                  70                  75                  80
 Glu Leu Phe Ala Val Val Lys Thr Met Gln Ala Leu Glu Lys Ala Tyr
                  85                  90                  95    
 Ile Lys Asp Cys Gly Leu Pro His Ala Ser Thr Ser Ala Gly Leu His
             100                 105                 110        
 Pro Arg Leu Leu Gly Pro Ile Thr Lys Leu Ala Phe Gln Ala Gly Ser
         115                 120                 125            
 Gln Gly Leu Gln Lys Phe Ser Ser Ile Asp Glu Phe Cys Arg Lys Phe
     130                 135                 140                
 Pro Pro Gly Thr Phe Pro Leu Ala Met Glu Arg Ile Lys Glu Asp Arg
 145                 150                 155                 160
 Pro Ile Thr Ile Lys Asp Asp Lys Gly Asn Leu Gln Pro Ala Cys Ile
                 165                 170                 175    
 Ala Asp Val Gly Leu Arg Ser Phe Ile Thr Val His Gly Gln Ala Cys
             180                 185                 190        
 Ala Leu Glu Ile Arg Pro Pro Met Asp Glu Ile Gln Pro Arg Thr Cys
         195                 200                 205            
 Gly Glu Pro Asp Gly Arg Thr His Ala Thr Ala Xaa Ala His Leu Pro
     210                 215                 220                
 Asn Pro Asn Phe Glu Gly Arg Pro Arg Arg Val His Gln Trp Leu Gln
 225                 230                 235                 240
 Thr Pro Glu Arg Ala Met Ser Gly Val Lys Met Ser Trp Asp Asp Ser
                 245                 250                 255    
 Gln Val Arg Gln Met Leu Phe Asp Leu Glu Ser Ala Tyr Asn Ala Phe
             260                 265                 270        
 Asn Arg Phe Leu His Ala
         275            



      <210> 602
      <211> 283
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(258)
      <223> Xaa = any amino acid or nothing 


      <400> 602
 Asp Phe Gln Ile Phe Ser Gly Glu Val Cys Phe Leu Gln Arg Phe Thr
   1               5                  10                  15    
 Asn Met Asn Ile Lys Gly Ser Pro Trp Lys Ala Gly Ser Leu Leu Leu
              20                  25                  30        
 Leu Leu Val Cys Ser Asn Leu Leu Leu Cys Gln Ser Val Gly Pro Leu
          35                  40                  45            
 Gly Pro Ser Val Pro Ala Gly Leu Ser Arg Cys Gln Gly Asp Pro Phe
      50                  55                  60                
 Glu Thr Leu Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn
  65                  70                  75                  80
 Leu Ser Ser Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly
                  85                  90                  95    
 Arg Gly Phe Ile Thr Lys Gly His Gln Gln Ala Cys His Thr Phe Phe
             100                 105                 110        
 Pro Leu Pro Thr Pro Arg Lys Thr Arg Glu Gln Ala Gln Gln Met Asn
         115                 120                 125            
 Gln Lys Asp Phe Leu Ser Leu Ile Ile Ser Ile Leu Arg Ser Trp Asn
     130                 135                 140                
 Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg Gly Met Gln Glu Ser
 145                 150                 155                 160
 Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Asp Xaa Gly Ser Lys
                 165                 170                 175    
 Thr Lys Arg Leu Pro Arg Gly Pro Trp Lys Leu Asp Ser Gln Ala Gln
             180                 185                 190        
 Val His Pro Xaa Lys Pro Lys Glu Asn Glu Ile Tyr Pro Val Trp Val
         195                 200                 205            
 Gly Asp Phe Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Pro Phe
     210                 215                 220                
 Leu Pro Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys
 225                 230                 235                 240
 Ile Asp Asn Tyr Leu Lys Leu Leu Lys Cys Arg Ile Ile His Asn Asn
                 245                 250                 255    
 Asn Cys
        



      <210> 603
      <211> 368
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(360)
      <223> Xaa = any amino acid or nothing 


      <400> 603
 Arg Gly Leu Lys Ala Lys Met Pro Phe Asp Ala Asn Lys Leu Tyr Cys
   1               5                  10                  15    
 Ser Glu Val Leu Ala Ile Leu Leu Gln Asp Asn Asp Glu Asn Arg Glu
              20                  25                  30        
 Leu Leu Gly Glu Leu Asp Gly Ile Asp Val Leu Leu Gln Gln Leu Ser
          35                  40                  45            
 Val Phe Lys Arg His Asn Pro Ser Thr Ala Glu Glu Gln Glu Met Met
      50                  55                  60                
 Glu Asn Leu Phe Asp Ser Leu Cys Ser Cys Leu Met Leu Ser Ser Asn
  65                  70                  75                  80
 Arg Glu Arg Phe Leu Lys Gly Glu Gly Leu Gln Leu Met Asn Leu Met
                  85                  90                  95    
 Leu Arg Glu Lys Lys Ile Ser Arg Ser Ser Ala Leu Lys Val Leu Asp
             100                 105                 110        
 His Ala Met Ile Gly Pro Glu Gly Thr Asp Asn Cys His Xaa Val Cys
         115                 120                 125            
 Leu Thr Phe Leu Ala Leu Arg Thr Ile Phe Pro Leu Phe Met Lys Ser
     130                 135                 140                
 Pro Arg Lys Ile Lys Lys Val Gly Thr Thr Glu Lys Glu His Glu Glu
 145                 150                 155                 160
 His Val Cys Ser Ile Leu Ala Ser Leu Leu Arg Asn Leu Arg Gly Gln
                 165                 170                 175    
 Gln Arg Thr Arg Leu Leu Asn Lys Phe Thr Glu Asn Asp Ser Glu Lys
             180                 185                 190        
 Val Asp Arg Leu Met Glu Leu His Phe Lys Tyr Leu Gly Ala Met Gln
         195                 200                 205            
 Val Ala Asp Lys Lys Ile Glu Gly Glu Lys His Asp Met Val Arg Arg
     210                 215                 220                
 Gly Glu Ile Ile Asp Asn Asp Thr Glu Glu Glu Phe Tyr Leu Arg Arg
 225                 230                 235                 240
 Leu Asp Ala Gly Leu Phe Val Ser Pro Lys His Ile Cys Tyr Ile Met
                 245                 250                 255    
 Ala Glu Ile Cys Asn Ala Asn Val Pro Gln Ile Arg Gln Arg Val His
             260                 265                 270        
 Gln Ile Leu Asn Met Arg Gly Ser Ser Ile Lys Ile Val Arg His Ile
         275                 280                 285            
 Ile Lys Gly Val Cys Arg Glu His Ser Gly Asp Gly Arg Ser Pro Glu
     290                 295                 300                
 Phe Pro Glu Glu Arg Ala Lys Ala His Pro Gly Leu Ala Gly Glu Leu
 305                 310                 315                 320
 Leu Glu Ala Pro Trp Ala Leu Arg Ile Met Gly Leu Ser Gln Leu Pro
                 325                 330                 335    
 Ser Gln Asp Gln Phe Leu His Asn Ser Val Trp Leu Leu Asp Lys Leu
             340                 345                 350        
 Lys Leu Val Leu Val Lys Lys Lys
         355                 360



      <210> 604
      <211> 508
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(487)
      <223> Xaa = any amino acid or nothing 


      <400> 604
 Pro Ala Arg Ala Val Phe Arg Ile Leu Gln Ala Ser Gly Ala His Val
   1               5                  10                  15    
 Gly Ser Arg Leu Pro Ser Leu Thr Glu Ser Pro Thr Ser Leu Pro Ser
              20                  25                  30        
 Cys Ile Ser Lys Met Ser Leu Ser Asn Lys Leu Thr Leu Asp Lys Leu
          35                  40                  45            
 Asp Val Lys Gly Lys Arg Val Val Met Arg Val Asp Phe Asn Val Pro
      50                  55                  60                
 Met Arg Ser His Gln Ile Thr Asn His Gln Arg Ile Lys Ala Ala Val
  65                  70                  75                  80
 Pro Ser Ile Gln Ile Leu Ala Leu Asp Asn Gly Ala Lys Ser Val Val
                  85                  90                  95    
 Leu Met Ser His Leu Gly Arg Pro Asp Gly Val Pro Met Pro Gly Gln
             100                 105                 110        
 Val Thr Pro Leu Glu Pro Val Ala Trp Xaa Asn Ser Asn Pro Leu Ala
         115                 120                 125            
 Trp Ala Arg Asp Val Leu Phe Leu Lys Gly Leu Cys Xaa Gly Pro Glu
     130                 135                 140                
 Val Gly Glu Lys Ala Cys Ala Asn Pro Ala Ser Trp Val Leu Ser Ser
 145                 150                 155                 160
 Leu Leu Glu Lys Pro Pro Ala Phe His Val Glu Glu Glu Gly Lys Gly
                 165                 170                 175    
 Lys Asp Ala Ser Gly Glu Gln Gly Leu Lys Pro Glu Pro Gly Gln Asn
             180                 185                 190        
 Arg Ser Phe Ser Glu Leu Ser Leu Ser Lys Leu Gly Asp Val Tyr Val
         195                 200                 205            
 Gln Xaa Met Leu Phe Gly Thr Ala His Arg Ala His Ser Phe Gln Val
     210                 215                 220                
 Gly Val Asn Leu Pro Gln Lys Ala Gly Gly Phe Leu Met Lys Lys Glu
 225                 230                 235                 240
 Leu Asn Tyr Phe Ala Lys Ala Leu Glu Ser Pro Glu Arg Pro Phe Leu
                 245                 250                 255    
 Ala Ile Leu Gly Gly Arg Lys Lys Leu Gln Thr Arg Phe Gln Leu Ile
             260                 265                 270        
 Asn Asn Met Leu Asp Lys Val Asn Glu Met Ile Ile Gly Gly Gly Met
         275                 280                 285            
 Ala Phe Thr Phe Leu Lys Val Leu Asn Asn Met Glu Ile Gly Thr Ser
     290                 295                 300                
 Leu Phe Asp Glu Glu Gly Ala Lys Ile Val Lys Asp Leu Met Phe Gln
 305                 310                 315                 320
 Ser Xaa Lys Arg Met Gly Val Lys Ile Thr Leu Pro Val Asp Phe Val
                 325                 330                 335    
 Thr Ala Asp Lys Phe Xaa Xaa Glu Met Pro Lys Thr Gly Gln Ala His
             340                 345                 350        
 Trp Trp Leu Leu Gly Ile Pro Ala Gly Leu Asp Gly Pro Leu Asp Cys
         355                 360                 365            
 Gly Pro Gly Lys Ala Gly Lys Glu Val Cys Leu Arg Ala Cys Ser Leu
     370                 375                 380                
 Gly Ala Lys Gln Asp Cys Val Gly Met Gly Pro Val Gly Gly Tyr Phe
 385                 390                 395                 400
 Glu Trp Glu Ala Phe Ala Arg Gly Asn Gln Lys Leu Ser Trp Asp Glu
                 405                 410                 415    
 Val Gly Glu Ser Thr Ser Asn Ser Arg Gly Leu Ala Phe Thr Ile His
             420                 425                 430        
 Arg Val Gly Trp Arg His Leu Pro Leu Gly Cys Cys Pro Asn Gly Asn
         435                 440                 445            
 Thr Gly Gly Xaa Lys Ser Ser His Val Glu Ser Leu Gly Gly Trp Cys
     450                 455                 460                
 Pro Val Trp Lys Leu Leu Gly Lys Val Lys Val Leu Thr Trp Gly Leu
 465                 470                 475                 480
 Asp Cys Ser Ser Ala Asn Val
                 485        



      <210> 605
      <211> 437
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(409)
      <223> Xaa = any amino acid or nothing 


      <400> 605
 Arg Val Asp Pro Arg Val Arg Ser Ser Pro Ser Ser Val Ser Arg Arg
   1               5                  10                  15    
 Asp Lys Ser Lys Gln Val Trp Glu Ala Val Leu Leu Pro Leu Ser Leu
              20                  25                  30        
 Leu Ser Met Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys
          35                  40                  45            
 Phe Ile Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile
      50                  55                  60                
 Asn His Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe
  65                  70                  75                  80
 Arg Gly Ile Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly
                  85                  90                  95    
 Ser Ser Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu
             100                 105                 110        
 Val Val Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg
         115                 120                 125            
 Arg Gly Glu Val His Pro Arg Lys Leu Gly Arg Gln Leu Glu Ala Cys
     130                 135                 140                
 Gln Ser Glu Arg Ala Phe Ser Val Lys Phe Glu Val Gln Ala Pro Arg
 145                 150                 155                 160
 Trp Gly Asn Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu
                 165                 170                 175    
 Arg Gly Glu Gly Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu
             180                 185                 190        
 Gly Gln Leu Thr Gly Gly Tyr Lys Pro Asn Pro Gln Ile Phe Val Lys
         195                 200                 205            
 Leu Ile Glu Glu Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr
     210                 215                 220                
 Cys Phe Thr Glu Leu Gln Arg Val Phe Leu Arg Gln Arg Pro Thr Lys
 225                 230                 235                 240
 Leu Lys Ser Leu Ile Arg Leu Val Gln His Trp Tyr Gln Tyr Cys Leu
                 245                 250                 255    
 Gly Met Ser Leu Gly Asn Leu Pro Pro Ser Val Cys Pro Cys Ile Leu
             260                 265                 270        
 Xaa Leu Ser Tyr Ala Trp Tyr Pro Gly Ser Met Lys Ser His Phe Asn
         275                 280                 285            
 Thr Ala Gln Gly Phe Arg Thr Val Leu Glu Leu Val Ile Asn Tyr Gln
     290                 295                 300                
 Gln Ile Cys Ile Tyr Leu Asn Lys Val Xaa Xaa Leu Xaa Lys Thr Pro
 305                 310                 315                 320
 Leu Phe Glu Lys Tyr Leu Arg Arg Gln Leu Thr Lys Pro Arg Pro Val
                 325                 330                 335    
 Ile Leu Asp Pro Ala Gly Pro Leu Gln Gly Asn Leu Gly Trp Trp Glu
             340                 345                 350        
 Asp Pro Lys Gly Trp Glu Ala Ser Trp Pro Gln Glu Ala Glu Ala Trp
         355                 360                 365            
 Leu Asn Tyr Pro Cys Phe Lys Asn Trp Gly Ser Val Pro Ser Glu Ala
     370                 375                 380                
 Pro Trp Ile Leu Leu Val Arg Pro Ser Cys Ser Ser Phe Pro Ala His
 385                 390                 395                 400
 Ser Ile Pro Ala Pro Leu His Glu Ala
                 405                



      <210> 606
      <211> 249
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(234)
      <223> Xaa = any amino acid or nothing 


      <400> 606
 Gly Val Pro Gly Gln Cys Pro Ser Thr Cys Pro Gln Ala Trp Gly Ile
   1               5                  10                  15    
 Ile Phe Ser Asn Leu Phe Lys Gly Leu Phe Gly Lys Lys Glu Met Arg
              20                  25                  30        
 Ile Leu Met Val Gly Leu Trp Asp Ala Ala Gly Lys Thr Thr Ile Leu
          35                  40                  45            
 Tyr Lys Leu Lys Leu Gly Glu Ile Val Thr Thr Ile Pro Thr Ile Gly
      50                  55                  60                
 Phe Asn Arg Gly Asn Pro Trp Lys Tyr Lys Asn Ile Gln Leu Ser Leu
  65                  70                  75                  80
 Cys Gly Asp Val Gly Trp Ala Arg Asp Lys Ile Arg Pro Leu Trp Ala
                  85                  90                  95    
 Pro Leu Thr Phe Gln Asn Thr Gln Gly Leu Ile Phe Arg Gly Trp Asp
             100                 105                 110        
 Ser Asn Xaa Gln Lys Ser Val Leu Asn Glu Gly Pro Leu Arg Ser Phe
         115                 120                 125            
 Ile Glu Gly Cys Trp Ala Gln Asp Glu Leu Arg Asp Ala Val Leu Leu
     130                 135                 140                
 Val Cys Phe Ala Lys Lys Ser Arg Asp Leu Pro Asn Ala Met Asn Ala
 145                 150                 155                 160
 Ala Glu Ile Thr Asp Lys Leu Gly Leu His Leu Thr Thr Pro Thr Gly
                 165                 170                 175    
 Asn Trp Tyr Ile Gln Ala Thr Cys Ala Thr Ser Gly Asp Gly Leu Leu
             180                 185                 190        
 Trp Lys Gly Leu Asp Trp Leu Ser Asn Gln Leu Pro Glu Pro Arg Ser
         195                 200                 205            
 Glu Pro Arg Pro Pro Leu Pro Leu Asn Ser Leu Gly Leu Cys Phe Thr
     210                 215                 220                
 Ser Met Trp Ala Thr Cys Arg Leu Val Val
 225                 230                



      <210> 607
      <211> 355
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(345)
      <223> Xaa = any amino acid or nothing 


      <400> 607
 Pro Val Ala Gln Gly Met Leu Arg Trp Thr Ala His Leu Glu Gly Gly
   1               5                  10                  15    
 Pro Arg Arg Val Asn His Ala Ala Val Ala Gly Gly His Arg Val Tyr
              20                  25                  30        
 Ser Phe Gly Gly Tyr Cys Ser Gly Glu Asn Tyr Xaa Thr Leu Arg Gln
          35                  40                  45            
 Ile Asp Val His Ile Phe Asn Ala Val Ser Leu Arg Trp Thr Lys Leu
      50                  55                  60                
 Pro Pro Gly Glu Val Cys His Pro Trp Ala Ser Ser Cys Ala Tyr Pro
  65                  70                  75                  80
 Tyr Met Arg Tyr Gly His Ser Thr Arg Pro His Ser Thr Thr Gln Ser
                  85                  90                  95    
 Tyr Leu Trp Gly Gly Arg Asn Asp Asp Pro Lys Gly Pro Cys Asn Val
             100                 105                 110        
 Leu Tyr Ala Phe Asp Val Glu Tyr Ala Gln Val Val His Asn Pro Glu
         115                 120                 125            
 Phe Ser Gly Thr Val Pro Gly Ala Arg Asp Gly His Ser Ala Cys Val
     130                 135                 140                
 Leu Trp Ala Arg Ser Cys Thr Phe Phe Gly Gly Tyr Glu Gln Gln Ala
 145                 150                 155                 160
 Asn Cys Phe Ser Asn Asp Ile His Lys Leu Asp Thr Ser Thr Met Thr
                 165                 170                 175    
 Trp Tyr Ser Tyr Arg Thr Lys Gly Ser Pro Ala Arg Trp Arg Asp Phe
             180                 185                 190        
 His Ser Ala Thr Met Ala Gly Lys Ser His Val Cys Leu Leu Gly Gly
         195                 200                 205            
 Arg Ala Val Arg Phe Gly Pro Phe His Ser Asn Asn Glu Ile Tyr Leu
     210                 215                 220                
 Gln Pro Thr Phe Glu Ser Leu Thr Pro Arg Thr Glu Ala Trp Leu Gly
 225                 230                 235                 240
 Leu Ser Pro Arg Leu Pro Val Leu Pro Xaa Gly Ala Pro Gly Ser His
                 245                 250                 255    
 Phe Gly Leu Trp Val Thr Met Gly Glu Leu Tyr Ile Phe Gly Gly Tyr
             260                 265                 270        
 Xaa Cys Lys Gly Trp Asn Arg His Phe Pro Xaa Pro Leu Gly Ser Phe
         275                 280                 285            
 Asn Pro Val Ser Phe Thr Trp Lys Lys Ile Glu Pro Lys Gly Lys Gly
     290                 295                 300                
 Pro Cys Pro Arg Arg Arg Gln Cys Cys Cys Ile Gly Gly Asp Lys Asn
 305                 310                 315                 320
 Val Leu Phe Trp Gly Tyr Gln Val His Leu Leu Arg Lys Ala Leu Gly
                 325                 330                 335    
 Asp Glu Phe Asp Leu Ile Asp Gln Ser
             340                 345



      <210> 608
      <211> 205
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(191)
      <223> Xaa = any amino acid or nothing 


      <400> 608
 Leu Phe His Phe Pro Tyr Leu Leu Arg Ala Ser Thr Ser Phe Phe Ser
   1               5                  10                  15    
 Leu Cys Pro Phe Cys Phe Ser Gln Ser Pro Arg Ile Met Lys Val Ala
              20                  25                  30        
 Ser Gly Ser Thr Ala Thr Ala Ala Ala Gly Pro Ser Cys Ala Leu Lys
          35                  40                  45            
 Ala Gly Lys Thr Ala Ser Gly Ala Cys Glu Val Val Arg Cys Leu Ser
      50                  55                  60                
 Glu Gln Ser Val Gly Ile Ser Arg Cys Ala Gly Gly Ala Gly Ala Arg
  65                  70                  75                  80
 Leu Pro Ser Leu Leu Glu Arg Gln Gln Val Asn Val Leu Leu Tyr Asp
                  85                  90                  95    
 Met Asn Gly Cys Tyr Ser Arg Leu Lys Glu Leu Val Pro Thr Leu Pro
             100                 105                 110        
 Gln Glu Pro Ala Arg Val Ser Lys Gly Gly Asp Phe Ser Lys His Val
         115                 120                 125            
 Ile Arg Leu Ile Ile Gln Gly Thr Phe Gln Leu Gly Ala Glu Thr Ser
     130                 135                 140                
 Gly Ile Pro Lys Leu Gly Thr Pro Gly Gly Pro Arg Gly Cys Arg Val
 145                 150                 155                 160
 Arg Ala Pro Leu Ser Thr Leu Asn Gly Glu Ile Gln Arg Pro Xaa Arg
                 165                 170                 175    
 Pro Arg Ala Ala Cys Val Pro Ala Asp Asp Arg Ile Leu Cys Arg
             180                 185                 190    



      <210> 609
      <211> 461
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(445)
      <223> Xaa = any amino acid or nothing 


      <400> 609
 Leu Ala Arg Pro Gln Arg Ala Gly Ala Gly Gln Cys Gly Gly Arg Trp
   1               5                  10                  15    
 Ser His Phe Arg Val Thr Ser Ser Cys Ala Cys Ser Val Gly Ala Pro
              20                  25                  30        
 Pro Ala Pro Ala Met Leu Ser Ala Leu Ala Arg Ala Val Pro Ser Ala
          35                  40                  45            
 Cys Ser Pro Arg Arg Ser Phe Ser Thr Ser Ala Gln Asn Asn Ala Lys
      50                  55                  60                
 Val Ala Val Leu Gly Ala Ser Gly Gly Ile Gly Gln Pro Leu Ser Leu
  65                  70                  75                  80
 Leu Leu Lys Asn Ser Pro Leu Gly Glu Pro Ala Leu Thr Leu Tyr Asp
                  85                  90                  95    
 Ile Arg Ala His Thr Pro Gly Val Gly Pro Gln Asn Leu Glu Pro Thr
             100                 105                 110        
 Ser Glu Asp Gln Lys Pro Ala Cys Xaa Lys Ala Tyr Leu Gly Pro Glu
         115                 120                 125            
 Gln Leu Gly Leu Asp Trp Pro Gly Lys Val Cys Xaa Cys Trp Xaa Val
     130                 135                 140                
 Tyr Phe Arg Val Gly Ser Ser Pro Glu Lys Pro Gly His Xaa Pro Gly
 145                 150                 155                 160
 Asn Asp Leu Phe Lys Gln Pro Met Ala Thr Ile Val Gly Asn Pro Gly
                 165                 170                 175    
 Pro Leu Ala Cys Ala Gln His Cys Pro Glu Ala Met Ile Cys Val Ile
             180                 185                 190        
 Ala Asn Pro Val Asn Ser Thr Ile Pro Ile Thr Ala Glu Val Phe Lys
         195                 200                 205            
 Lys Ala Trp Gly Gln His Pro Gln Lys Lys Ser Ser Gly Val Thr Thr
     210                 215                 220                
 Leu Asn Ile Val Gly Ala Gly Thr Phe Val Ala Glu Leu Lys Gly Leu
 225                 230                 235                 240
 Asp Pro Ala Arg Val Asn Val Pro Ile Thr Gly Gly His Ala Gly Lys
                 245                 250                 255    
 Thr Ile Ile Pro Leu Ile Ser Gln Val His Pro Lys Arg Trp Thr Phe
             260                 265                 270        
 Pro Gln Asp Gln Leu Thr Ala Leu Thr Gly Arg Ile Gln Glu Ala Gly
         275                 280                 285            
 Thr Lys Val Val Lys Ala Lys Ala Gly Ala Arg Arg Leu Pro Thr Leu
     290                 295                 300                
 Ser Gln Cys Arg Asn Gly Arg Arg Pro Gly Phe Val Phe Ser Leu Cys
 305                 310                 315                 320
 Gly Met Gln Met Asn Trp Lys Arg Lys Gly Val Cys Gly Asn Val Pro
                 325                 330                 335    
 Leu Arg Xaa Ser Pro Gln Glu Asn Gly Met Tyr Pro Tyr Phe Leu Pro
             340                 345                 350        
 His Pro Leu Pro Ala Leu Gly Lys Arg Ala Ile Glu Lys Lys Lys Ala
         355                 360                 365            
 Lys Thr Ser Gly Pro Ser Ala Lys Val Ser Phe Phe Leu Arg Arg Lys
     370                 375                 380                
 Met Ile Ser Asp Ala Pro Ser Pro Glu Leu Lys Ala Leu Pro Ser Arg
 385                 390                 395                 400
 Met Gly Glu Asp Phe Val Lys Thr Leu Lys Val Ser Arg Cys Asp Gly
                 405                 410                 415    
 Trp Pro Ser Phe Pro Tyr Phe Met Lys Ala Ile Met Ser Thr Ala Lys
             420                 425                 430        
 Pro Leu Pro Asp Lys Thr Leu Tyr Phe Asn Leu Leu Trp
         435                 440                 445



      <210> 610
      <211> 239
      <212> PRT
      <213> Homo sapiens


      <400> 610
 Asp Ser Leu Asp Asn His Arg Cys Arg Gly Asp Leu Thr Lys Thr Tyr
   1               5                  10                  15    
 Ser Leu Glu Ala Tyr Asp Asn Trp Phe Asn Cys Leu Ser Met Leu Val
              20                  25                  30        
 Ala Thr Glu Val Cys Arg Val Val Lys Lys Lys His Arg Thr Arg Met
          35                  40                  45            
 Leu Glu Phe Phe Ile Asp Val Ala Arg Glu Cys Phe Asn Ile Gly Asn
      50                  55                  60                
 Phe Asn Ser Met Met Ala Ile Ile Ser Gly Met Asn Leu Ser Pro Val
  65                  70                  75                  80
 Ala Arg Leu Lys Lys Thr Trp Ser Lys Val Lys Thr Ala Lys Phe Asp
                  85                  90                  95    
 Val Leu Glu His His Met Asp Pro Ser Ser Asn Phe Cys Asn Tyr Arg
             100                 105                 110        
 Thr Ala Leu Gln Gly Ala Thr Gln Arg Ser Gln Met Ala Asn Ser Ser
         115                 120                 125            
 Arg Glu Lys Ile Val Ile Pro Val Phe Asn Leu Phe Val Lys Asp Ile
     130                 135                 140                
 Tyr Phe Leu Pro Gln Asn Pro Ser Asn His Leu Pro Asn Gly His Ile
 145                 150                 155                 160
 Asn Phe Lys Lys Phe Trp Glu Ile Ser Arg Gln Ile His Glu Phe Met
                 165                 170                 175    
 Thr Trp Thr Gln Val Glu Cys Pro Phe Glu Lys Asp Lys Lys Ile Pro
             180                 185                 190        
 Ser Tyr Leu Leu Thr Ala Pro His Pro Thr Ala Arg Lys Leu Ser Ser
         195                 200                 205            
 Ser Pro Ser Phe Glu Ser Glu Gly Pro Glu Asn His Met Glu Lys Asp
     210                 215                 220                
 Ser Trp Lys Thr Leu Arg Thr Thr Leu Leu Asn Arg Ala
 225                 230                 235        



      <210> 611
      <211> 1027
      <212> PRT
      <213> Homo sapiens


      <400> 611
 Glu Glu Glu Leu Glu Ala Ser Lys Ser Phe Gly Pro Gly Asn Glu Glu
   1               5                  10                  15    
 Glu Glu Lys Glu Glu Lys Glu Tyr Glu Glu Glu Glu Glu Glu Asp Tyr
              20                  25                  30        
 Asp Glu Glu Glu Glu Glu Ser Ser Glu Ala Gly Asn Gln Arg Leu Gln
          35                  40                  45            
 Gln Val Met His Ala Ala Asp Pro Leu Glu Ile Gln Ala Asp Val His
      50                  55                  60                
 Trp Thr His Ile Arg Glu Arg Glu Glu Glu Glu Arg Met Ala Pro Ala
  65                  70                  75                  80
 Ser Glu Ser Ser Ala Ser Gly Ala Pro Leu Asp Glu Asn Asp Leu Glu
                  85                  90                  95    
 Glu Asp Val Asp Ser Glu Pro Ala Glu Ile Glu Gly Glu Ala Ala Glu
             100                 105                 110        
 Asp Gly Asp Pro Gly Asp Thr Gly Ala Glu Leu Asp Asp Asp Gln His
         115                 120                 125            
 Trp Ser Asp Ser Pro Ser Asp Ala Asp Arg Glu Leu Arg Leu Pro Cys
     130                 135                 140                
 Pro Ala Glu Gly Glu Ala Glu Leu Glu Leu Arg Val Ser Glu Asp Glu
 145                 150                 155                 160
 Glu Lys Leu Pro Ala Ser Pro Lys His Gln Glu Arg Gly Pro Ser Gln
                 165                 170                 175    
 Ala Thr Ser Pro Ile Arg Ser Pro Gln Glu Ser Ala Leu Leu Phe Ile
             180                 185                 190        
 Pro Val His Ser Pro Ser Thr Glu Gly Pro Gln Leu Pro Pro Val Pro
         195                 200                 205            
 Ala Ala Thr Gln Glu Lys Ser Pro Glu Glu Arg Leu Phe Pro Glu Pro
     210                 215                 220                
 Leu Leu Pro Lys Glu Lys Pro Lys Ala Asp Ala Pro Ser Asp Leu Lys
 225                 230                 235                 240
 Ala Val His Ser Pro Ile Arg Ser Gln Pro Val Thr Leu Pro Glu Ala
                 245                 250                 255    
 Arg Thr Pro Val Ser Pro Gly Ser Pro Gln Pro Arg Pro Pro Val Ala
             260                 265                 270        
 Ala Ser Thr Pro Pro Pro Ser Pro Leu Pro Ile Cys Ser Gln Pro Gln
         275                 280                 285            
 Pro Ser Thr Glu Ala Thr Val Pro Ser Pro Thr Gln Ser Pro Ile Arg
     290                 295                 300                
 Phe Gln Pro Ala Pro Ala Lys Thr Ser Thr Pro Leu Ala Pro Leu Pro
 305                 310                 315                 320
 Val Gln Ser Gln Ser Asp Thr Lys Asp Arg Leu Gly Ser Pro Leu Ala
                 325                 330                 335    
 Val Asp Glu Ala Leu Arg Arg Ser Asp Leu Val Glu Glu Phe Trp Met
             340                 345                 350        
 Lys Ser Ala Glu Ile Arg Arg Ser Leu Gly Leu Thr Pro Val Asp Arg
         355                 360                 365            
 Ser Lys Gly Pro Glu Pro Ser Phe Pro Thr Pro Ala Phe Arg Pro Val
     370                 375                 380                
 Ser Leu Lys Ser Tyr Ser Val Glu Lys Ser Pro Gln Asp Glu Gly Leu
 385                 390                 395                 400
 His Leu Leu Lys Pro Leu Ser Ile Pro Lys Arg Leu Gly Leu Pro Lys
                 405                 410                 415    
 Pro Glu Gly Glu Pro Leu Ser Leu Pro Thr Pro Arg Ser Pro Ser Asp
             420                 425                 430        
 Arg Glu Leu Arg Ser Ala Gln Glu Glu Arg Arg Glu Leu Ser Ser Ser
         435                 440                 445            
 Ser Gly Leu Gly Leu His Gly Ser Ser Ser Asn Met Lys Thr Leu Gly
     450                 455                 460                
 Ser Gln Ser Phe Asn Thr Ser Asp Ser Ala Met Leu Thr Pro Pro Ser
 465                 470                 475                 480
 Ser Pro Pro Pro Pro Pro Pro Pro Gly Glu Glu Pro Ala Thr Leu Arg
                 485                 490                 495    
 Arg Lys Leu Arg Glu Ala Glu Pro Asn Ala Ser Val Val Pro Pro Pro
             500                 505                 510        
 Leu Pro Ala Thr Trp Met Arg Pro Pro Arg Glu Pro Ala Gln Pro Pro
         515                 520                 525            
 Arg Glu Glu Val Arg Lys Ser Phe Val Glu Ser Val Glu Glu Ile Pro
     530                 535                 540                
 Phe Ala Asp Asp Val Glu Asp Thr Tyr Asp Asp Lys Thr Glu Asp Ser
 545                 550                 555                 560
 Ser Leu Gln Glu Lys Phe Phe Thr Pro Pro Ser Cys Trp Pro Arg Pro
                 565                 570                 575    
 Glu Lys Pro Arg His Pro Pro Leu Ala Lys Glu Asn Gly Arg Leu Pro
             580                 585                 590        
 Ala Leu Glu Gly Thr Leu Gln Pro Gln Lys Arg Gly Leu Pro Leu Val
         595                 600                 605            
 Ser Ala Glu Ala Lys Glu Leu Ala Glu Glu Arg Met Arg Ala Arg Glu
     610                 615                 620                
 Lys Ser Val Lys Ser Gln Ala Leu Arg Asp Ala Met Ala Arg Gln Leu
 625                 630                 635                 640
 Ser Arg Met Gln Gln Met Glu Leu Ala Ser Gly Ala Pro Arg Pro Arg
                 645                 650                 655    
 Lys Ala Ser Ser Ala Pro Ser Gln Gly Lys Glu Arg Arg Pro Asp Ser
             660                 665                 670        
 Pro Thr Arg Pro Thr Leu Arg Gly Ser Glu Glu Pro Thr Leu Lys His
         675                 680                 685            
 Glu Ala Thr Ser Glu Glu Val Leu Ser Pro Pro Ser Asp Ser Gly Gly
     690                 695                 700                
 Pro Asp Gly Ser Phe Thr Ser Ser Glu Gly Ser Ser Gly Lys Ser Lys
 705                 710                 715                 720
 Lys Arg Ser Ser Leu Phe Ser Pro Arg Arg Asn Lys Lys Glu Lys Lys
                 725                 730                 735    
 Ser Lys Gly Glu Gly Arg Pro Pro Glu Lys Pro Ser Ser Asn Leu Leu
             740                 745                 750        
 Glu Glu Ala Val Ala Lys Pro Lys Ser Leu Trp Lys Ser Val Phe Ser
         755                 760                 765            
 Gly Tyr Lys Lys Asp Lys Lys Lys Lys Ala Asp Asp Lys Ser Cys Pro
     770                 775                 780                
 Ser Thr Pro Phe Ser Gly Ala Thr Val Asp Ser Gly Lys His Arg Val
 785                 790                 795                 800
 Leu Pro Val Val Arg Ala Glu Leu Gln Leu Arg Arg Gln Leu Ser Phe
                 805                 810                 815    
 Ser Glu Asp Ser Asp Leu Ser Ser Asp Asp Val Leu Glu Lys Ser Ser
             820                 825                 830        
 Gln Lys Ser Arg Arg Glu Pro Arg Thr Tyr Thr Glu Glu Glu Leu Asn
         835                 840                 845            
 Ala Lys Leu Thr Arg Arg Val Gln Lys Ala Ala Arg Arg Gln Ala Lys
     850                 855                 860                
 Gln Glu Glu Leu Lys Arg Leu His Arg Ala Gln Ile Ile Gln Arg Gln
 865                 870                 875                 880
 Leu Gln Gln Val Glu Glu Arg Gln Arg Arg Leu Glu Glu Arg Gly Val
                 885                 890                 895    
 Ala Val Glu Lys Ala Leu Arg Gly Glu Ala Gly Met Gly Lys Lys Asp
             900                 905                 910        
 Asp Pro Lys Leu Met Gln Glu Trp Phe Lys Leu Val Gln Glu Lys Asn
         915                 920                 925            
 Ala Met Val Arg Tyr Glu Ser Glu Leu Met Ile Phe Ala Arg Glu Leu
     930                 935                 940                
 Glu Leu Glu Asp Arg Gln Ser Arg Leu Gln Gln Glu Leu Arg Glu Arg
 945                 950                 955                 960
 Met Ala Val Glu Asp His Leu Lys Thr Glu Glu Glu Leu Ser Glu Glu
                 965                 970                 975    
 Lys Gln Ile Leu Asn Glu Met Leu Glu Val Val Glu Gln Arg Asp Ser
             980                 985                 990        
 Leu Val Ala Leu Leu Glu Glu Gln Arg Leu Arg Glu Arg Glu Glu Asp
         995                1000                1005            
 Lys Asp Leu Glu Ala Ala Met Leu Ser Lys Gly Phe Ser Leu Asn Trp
    1010                1015                1020                
 Ser
1025



      <210> 612
      <211> 132
      <212> PRT
      <213> Homo sapiens


      <400> 612
 Met Phe Ser Leu Gly Ser Val Val Ile Phe Ala Thr Phe Val Thr Leu
   1               5                  10                  15    
 Cys Asn Ala Ser Cys Tyr Phe Ile Pro Leu Met Arg Glu Phe Pro Gly
              20                  25                  30        
 Asp Ser Thr Arg Lys Cys Met Asp Leu Lys Gly Asn Lys His Pro Ile
          35                  40                  45            
 Asn Ser Glu Trp Gln Thr Asp Asn Cys Glu Thr Ser Thr Cys Tyr Glu
      50                  55                  60                
 Thr Glu Ile Ser Cys Cys Thr Leu Val Ser Thr Pro Val Gly Tyr Asp
  65                  70                  75                  80
 Lys Asp Asn Cys Gln Arg Ile Phe Gln Glu Gly Arg Leu Ala Met Tyr
                  85                  90                  95    
 Ile Val Val Glu Lys Lys Gly Pro Gln Lys Lys Thr Cys Pro Val Ser
             100                 105                 110        
 Glu Trp Gln Thr Asp Asn Leu
         115                



      <210> 613
      <211> 212
      <212> PRT
      <213> Homo sapiens


      <400> 613
 Ser Arg Ala Ala Ser Glu Met Gln His Arg Gly Phe Leu Leu Leu Thr
   1               5                  10                  15    
 Leu Leu Ala Leu Leu Ala Leu Thr Ala Ala Val Ala Lys Lys Lys Asp
              20                  25                  30        
 Lys Val Lys Lys Gly Gly Pro Gly Glu Arg Val Pro Leu Lys Trp Ala
          35                  40                  45            
 Trp Gly Pro Cys Thr Pro Ser Ser Lys Asp Cys Arg Val Val Phe Arg
      50                  55                  60                
 Lys Gly Thr Cys Gly Ala Gln Thr Lys Gly Ile Arg Cys Arg Val Pro
  65                  70                  75                  80
 Cys Asn Trp Lys Lys Glu Phe Gly Ala Gly Leu Gln Ser Pro Ser Phe
                  85                  90                  95    
 Glu Asn Trp Gly Ala Cys Asp Val Gly Thr Gly Asn Gln Lys Val Arg
             100                 105                 110        
 Gln Gly Thr Leu Lys Lys Ala Arg Tyr Asn Val Gln Cys Gln Glu Thr
         115                 120                 125            
 Ile Arg Val Asn Gln Ser Pro Cys Asn Pro Pro Arg Thr Lys Arg Gln
     130                 135                 140                
 Arg Pro Lys Ala Lys Lys Gly Lys Gly Lys Asp Leu Glu Arg Gln Ala
 145                 150                 155                 160
 Ser Asp Ala Gln Gly Ala Pro Gly Val Thr Trp Gly Pro Gly Pro Thr
                 165                 170                 175    
 Ala Pro Pro Ser Pro Gly Ala Arg Arg Cys Asp Pro Thr Ser Ala Phe
             180                 185                 190        
 Leu Ser Ala Arg
         195    



      <210> 614
      <211> 571
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(567)
      <223> Xaa = any amino acid or nothing 


      <400> 614
 Glu Ser Glu Asp Arg Asp Phe Phe Leu Thr Met Asn Val Thr Pro Glu
   1               5                  10                  15    
 Val Lys Ser Arg Gly Met Lys Phe Ala Glu Glu Gln Leu Leu Lys His
              20                  25                  30        
 Gly Trp Thr Gln Gly Lys Gly Leu Gly Arg Lys Glu Asn Gly Ile Thr
          35                  40                  45            
 Gln Ala Leu Arg Val Thr Leu Lys Gln Asp Thr His Gly Val Gly His
      50                  55                  60                
 Asp Pro Ala Lys Glu Phe Thr Asn His Trp Trp Asn Glu Leu Phe Asn
  65                  70                  75                  80
 Lys Thr Ala Ala Asn Leu Val Val Glu Thr Gly Gln Asp Gly Val Gln
                  85                  90                  95    
 Ile Arg Ser Leu Ser Lys Glu Thr Thr Arg Tyr Asn His Pro Lys Pro
             100                 105                 110        
 Asn Leu Leu Tyr Gln Lys Phe Val Lys Met Ala Thr Leu Thr Ser Gly
         115                 120                 125            
 Gly Glu Lys Pro Asn Lys Asp Leu Glu Ser Cys Ser Asp Asp Asp Asn
     130                 135                 140                
 Gln Gly Ser Lys Ser Pro Asn Asp Ser Asp Xaa Xaa Asp Ala Asp Ser
 145                 150                 155                 160
 Lys Pro Val Arg Gly Glu Gln His Thr Arg Leu Pro Val Leu Gly Ser
                 165                 170                 175    
 Gln Xaa Arg Pro Ser Tyr Ala Arg Leu Glu Ala Gln Glu Gln Ala Phe
             180                 185                 190        
 Leu Ala Arg Leu Lys Gly Gln Asp Pro Gly Ala Pro Gln Leu Gln Ser
         195                 200                 205            
 Glu Ser Lys Pro Pro Lys Lys Lys Lys Lys Lys Arg Arg Gln Lys Glu
     210                 215                 220                
 Glu Glu Glu Ala Thr Ala Ser Glu Arg Asn Asp Ala Asp Glu Lys His
 225                 230                 235                 240
 Pro Glu His Ala Glu Gln Asn Ile Arg Lys Ser Lys Lys Lys Lys Arg
                 245                 250                 255    
 Arg His Gln Glu Gly Lys Val Ser Asp Glu Arg Glu Gly Thr Thr Lys
             260                 265                 270        
 Gly Asn Glu Lys Glu Asp Ala Ala Gly Thr Ser Gly Leu Gly Glu Leu
         275                 280                 285            
 Asn Ser Arg Glu Gln Thr Asn Gln Ser Leu Arg Lys Gly Lys Lys Lys
     290                 295                 300                
 Lys Arg Trp His His Glu Glu Glu Lys Met Gly Val Leu Glu Glu Gly
 305                 310                 315                 320
 Gly Lys Gly Lys Glu Ala Ala Gly Ser Val Arg Thr Glu Glu Val Glu
                 325                 330                 335    
 Ser Arg Ala Tyr Ala Asp Pro Cys Ser Arg Arg Lys Lys Arg Gln Gln
             340                 345                 350        
 Gln Glu Glu Glu Asp Leu Asn Leu Glu Asp Arg Gly Glu Glu Thr Val
         355                 360                 365            
 Leu Gly Gly Gly Thr Arg Glu Ala Glu Ser Arg Ala Cys Ser Asp Gly
     370                 375                 380                
 Arg Ser Arg Lys Ser Lys Lys Lys Arg Gln Gln His Gln Glu Glu Glu
 385                 390                 395                 400
 Asp Ile Leu Asp Val Arg Asp Glu Lys Asp Ser Gly Ala Arg Glu Ala
                 405                 410                 415    
 Glu Ser Arg Ala His Thr Gly Ser Ser Ser Arg Gly Lys Arg Lys Arg
             420                 425                 430        
 Gln Gln His Pro Lys Lys Glu Arg Ala Gly Val Ser Thr Val Gln Lys
         435                 440                 445            
 Ala Lys Lys Lys Gln Lys Lys Arg Asp Xaa Arg Ser Gly Lys Gly Arg
     450                 455                 460                
 Ala Gln Leu Ile Asp Phe Gln Glu Leu Lys Pro Gln Arg Pro Gly Leu
 465                 470                 475                 480
 Met Gln Val Cys Arg Ser Ser Ala Pro Pro Ser Met Arg Lys Ser Leu
                 485                 490                 495    
 Pro Glu Arg Lys Leu Ile Ser Gly Met Ser Ala Ala Glu Arg Ser Lys
             500                 505                 510        
 Arg Xaa Tyr His Pro Leu Val Glu Gly Val Ser Thr Val Leu Ser Ala
         515                 520                 525            
 Ala Ser Asn Pro Gly Pro Xaa Thr Gln Val Pro Arg Glu Ala Arg Gln
     530                 535                 540                
 Leu Lys Asp Lys Glu Cys Trp Gly Leu Trp Glu Gln Glu Cys Arg Tyr
 545                 550                 555                 560
 Pro Leu Lys Glu His Ser Cys
                 565        



      <210> 615
      <211> 108
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(106)
      <223> Xaa = any amino acid or nothing 


      <400> 615
 Ser Arg Lys Pro Val Gly Ala Ala Trp Ser Arg Leu Lys Leu Leu Phe
   1               5                  10                  15    
 Ser Asp Gly Glu Lys Val Ile Pro Arg Val Thr His Glu Leu Pro Gly
              20                  25                  30        
 Ile Lys Arg Gly Arg Gln Ala Glu Glu Glu Cys Ala His Arg Gly Ser
          35                  40                  45            
 Pro Leu Pro Lys Lys Arg Lys Gly Trp Pro Pro Gly His Ile Leu Ser
      50                  55                  60                
 Ser Asp Arg Ala Ala Ala Gly Met Val Trp Lys Pro Lys Ser Arg Asp
  65                  70                  75                  80
 Pro Val Arg Arg Glu Gly Pro Lys Xaa Asp Thr Ala Arg Leu Asn Glu
                  85                  90                  95    
 Ser Thr Pro Tyr Val Leu Gly Ala Leu Phe
             100                 105    



      <210> 616
      <211> 78
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(77)
      <223> Xaa = any amino acid or nothing 


      <400> 616
 Gly Gly Lys Leu Ile Asn Ile Lys Tyr Leu Phe Tyr Thr Ser Tyr Xaa
   1               5                  10                  15    
 Phe Leu Ser Phe Pro Trp His Phe Leu Leu Ala Ala Ser Arg Ala Gln
              20                  25                  30        
 Gln Gly Glu Val Met Arg Leu Ala Cys Arg Leu Asp Pro Lys Thr Ser
          35                  40                  45            
 Phe Gln Met Ala Gly Glu Trp Leu Lys Tyr Gln Leu Ser Thr Phe Leu
      50                  55                  60                
 Asp Ala Gly Ser Val Asn Trp Lys Phe Phe Ser Leu Leu
  65                  70                  75        



      <210> 617
      <211> 193
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(192)
      <223> Xaa = any amino acid or nothing 


      <400> 617
 Gly Pro Ala Arg Ser Thr Ser Val Gln Ser Xaa Ala Pro Gln Leu Ala
   1               5                  10                  15    
 Thr Asp Val Ser Arg Ala Pro Ser Gly Ser Ser Cys Ala Trp Pro Pro
              20                  25                  30        
 Gly Gln Ser Leu Ser Cys Arg His Ser Ala Ala Glu Lys Leu His Ala
          35                  40                  45            
 Pro Ile Pro Phe Ala Asn Lys Leu Gln Gly Pro Lys Ala Ser Pro Thr
      50                  55                  60                
 Gln Cys His Arg Ser Leu Leu Gln Leu Val Lys Thr Ala Ala Lys Gly
  65                  70                  75                  80
 Gln Gly Phe His Pro Ser Ala Pro Ala Thr Ser Gly Gly Leu Ser Ala
                  85                  90                  95    
 Ser Ser Ser Ser Ser His Lys Thr Pro Ala Ser Ser Ser Ser Ala Leu
             100                 105                 110        
 Ser His Pro Ala Lys Pro His Ser Val Ser Ser Ala Gly Ser Ser Tyr
         115                 120                 125            
 Lys Asn Asn Pro Phe Ala Ser Ser Ile Ser Lys His Gly Val Ser Ser
     130                 135                 140                
 Gly Ser Ser Ser Ser Gly Gly Thr Pro Val Gln Ser Ser Val Ser Gly
 145                 150                 155                 160
 Ser Leu Val Pro Gly Ile Gln Pro Pro Ser Val Gly Gln Ala Thr Ser
                 165                 170                 175    
 Arg Pro Val Pro Ser Ser Ala Gly Lys Lys Met Pro Gly Phe Pro Lys
             180                 185                 190        





      <210> 618
      <211> 133
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(132)
      <223> Xaa = any amino acid or nothing 


      <400> 618
 His Ser Ile Thr His Arg Leu Thr His Ser Arg Glu Lys Ser Cys Glu
   1               5                  10                  15    
 Cys Asn Leu Tyr Gly Lys Thr Leu Ser Ser Asn Phe Pro Pro Thr Lys
              20                  25                  30        
 Lys Lys Val Ser Thr Gly Glu Leu Pro Arg Xaa Cys Ser Ser Cys Arg
          35                  40                  45            
 Lys Ala Phe Ser Glu Ala Ser Gly Ser His Met Thr Thr His Asn Lys
      50                  55                  60                
 Gly Lys Pro Cys Val Trp His Gln Lys Trp Lys Thr Arg Gly His Ser
  65                  70                  75                  80
 Phe Leu Lys Ser His Phe Gly Asp His Thr Thr Glu Glu Tyr Val Glu
                  85                  90                  95    
 Tyr Thr Gln Cys Xaa Lys Ala Cys Asp Thr Asn Ser His Ile Thr Lys
             100                 105                 110        
 His Lys Thr Val Xaa Phe Gly Asp His Thr Thr Glu Glu Tyr Val Glu
         115                 120                 125            
 Tyr Thr Gln Cys
     130        



      <210> 619
      <211> 133
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(132)
      <223> Xaa = any amino acid or nothing 


      <400> 619
 Pro Leu Gln Asn Cys Lys Ala Pro Lys Gly Gly Asp Lys Arg Ser Xaa
   1               5                  10                  15    
 Ser Leu Pro Pro Arg Cys Ser Arg Arg Glu Pro Arg Met Tyr Trp Arg
              20                  25                  30        
 Met Gly Pro Ala Cys Thr Pro Gly Arg Arg Pro Pro Arg Thr Pro Thr
          35                  40                  45            
 Pro Pro His Cys Glu Arg Leu Thr Pro Ala Thr Gly Lys Arg Gly Arg
      50                  55                  60                
 Pro Pro Thr Arg Arg Pro Pro Cys Gln Ala Gly Arg Gly His Ala Arg
  65                  70                  75                  80
 Arg Gln Gly Pro Cys Ala Gln Leu Leu Leu Ala Gly Trp Ala Arg Glu
                  85                  90                  95    
 Pro Ala Ser Arg Pro His Thr Ala Cys Pro Pro Gln Gly Lys Ala Ser
             100                 105                 110        
 His Phe Arg Ser Ala Pro Val Pro Ala Arg Leu Ser Pro Val Ile Ser
         115                 120                 125            
 Glu Pro Met Tyr
     130        



      <210> 620
      <211> 121
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(119)
      <223> Xaa = any amino acid or nothing 


      <400> 620
 Asn Thr Ala Pro Val Thr Cys Ala Arg Gly Cys Gly Arg Gly Gln His
   1               5                  10                  15    
 Arg Ser Arg Ser Arg Gly Arg Gly Met Xaa Ala Phe Xaa Ala Asn Ser
              20                  25                  30        
 Gln Ser Thr Gln Gly Arg Asn Arg Arg Leu Glu Ala Gly Gln Arg Gly
          35                  40                  45            
 Cys Arg Ala Gln Thr His Val His Gly Phe Pro Thr Arg Arg Ala Trp
      50                  55                  60                
 Gln Arg Thr His Trp Pro Pro Pro Gly Gly Ala Gly Ser Ala Thr Ala
  65                  70                  75                  80
 Ala Pro Phe Met Arg Pro Val Phe Arg Ser Cys Thr Ser Pro Lys Ala
                  85                  90                  95    
 Gln Arg Arg Arg Asp Arg His Ser Arg Arg Pro Arg Cys Arg Asp Arg
             100                 105                 110        
 Met Trp Pro Ser Arg Arg Gln
         115                



      <210> 621
      <211> 329
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(328)
      <223> Xaa = any amino acid or nothing 


      <400> 621
 Asn Ser Arg Val Asp Asp Phe Val Gly Lys Met Ala Ala Ser Arg Asn
   1               5                  10                  15    
 Gly Phe Glu Ala Val Glu Ala Glu Gly Ser Ala Gly Cys Arg Gly Ser
              20                  25                  30        
 Ser Gly Met Glu Val Val Leu Pro Leu Asp Pro Ala Val Pro Ala Pro
          35                  40                  45            
 Leu Cys Pro His Gly Pro Thr Leu Leu Phe Val Lys Val Thr Gln Gly
      50                  55                  60                
 Lys Glu Glu Thr Arg Arg Phe Tyr Ala Cys Ser Ala Cys Arg Asp Arg
  65                  70                  75                  80
 Lys Asp Cys Asn Phe Phe Gln Trp Glu Glu Xaa Lys Val Val Arg Ser
                  85                  90                  95    
 Xaa Thr Cys Cys Pro Arg Ser Ser Xaa Pro Lys Asp Val Ser Leu Pro
             100                 105                 110        
 Cys Pro Glu Arg Ser Val Trp Lys Gly Thr Xaa Ser Leu Leu Ser Cys
         115                 120                 125            
 Pro Cys His Gln Arg Lys Phe Cys Gln Thr Cys Gln Gln Leu Leu Leu
     130                 135                 140                
 Pro Asp Asp Trp Gly Gln His Ser Glu His Gln Val Leu Gly Asn Val
 145                 150                 155                 160
 Ser Ile Thr Gln Leu Arg Arg Pro Ser Gln Leu Leu Tyr Pro Leu Glu
                 165                 170                 175    
 Asn Lys Lys Thr Asn Ala Gln Tyr Leu Phe Ala Asp Arg Ser Cys Gln
             180                 185                 190        
 Phe Leu Val Asp Leu Leu Ser Ala Leu Gly Phe Arg Arg Val Leu Cys
         195                 200                 205            
 Val Gly Thr Pro Arg Leu His Glu Leu Ile Lys Leu Thr Ala Ser Gly
     210                 215                 220                
 Asp Lys Lys Ser Asn Ile Lys Ser Leu Leu Leu Asp Ile Asp Phe Arg
 225                 230                 235                 240
 Tyr Ser Gln Phe Phe Met Glu Asp Ser Phe Cys His Tyr Asn Met Phe
                 245                 250                 255    
 Asn His His Phe Phe Asp Gly Lys Thr Ala Leu Glu Val Cys Arg Ala
             260                 265                 270        
 Phe Leu Gln Glu Asp Lys Gly Glu Gly Ile Ile Met Val Thr Asp Pro
         275                 280                 285            
 Pro Phe Gly Gly Leu Val Glu Pro Leu Ala Ile Thr Phe Lys Lys Leu
     290                 295                 300                
 Ile Ala Met Trp Lys Glu Gly Gln Ser Gln Gly Val Xaa Phe Ile Thr
 305                 310                 315                 320
 Ala Lys Xaa Ile His Ile Tyr Ile
                 325            



      <210> 622
      <211> 139
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(136)
      <223> Xaa = any amino acid or nothing 


      <400> 622
 Ser Gln Cys Gly Gly Ile Pro Gln Val Gly Glu Ile Phe Ser Ala Ala
   1               5                  10                  15    
 Gly Ala Ala Phe Thr Lys Leu Gly Glu Leu Thr Met Gln Leu His Pro
              20                  25                  30        
 Val Ala Asp Ser Ser Pro Ala Gly Ala Lys Trp Thr Glu Thr Glu Ile
          35                  40                  45            
 Glu Met Pro Glu Gly Cys Cys Glu Ala Ile Trp Gly Arg Ser Xaa Ser
      50                  55                  60                
 His Gln Leu Cys His Gln Gly Thr Asp Ser Gly Pro Asp Lys Gly His
  65                  70                  75                  80
 Cys Glu Thr Gln Gly Ile Xaa Ser Ser Gly Ile Pro Leu Pro Ala Glu
                  85                  90                  95    
 Ser Pro Lys Lys Gly Pro Lys Lys Val Ala Ser Gly Val Leu Ser Pro
             100                 105                 110        
 Pro Pro Ala Ala Pro Pro Pro Ser Ser Ser Ser Val Pro Glu Ala Trp
         115                 120                 125            
 Gly Ser Pro His Lys Glu Thr Glu
     130                 135    



      <210> 623
      <211> 33
      <212> PRT
      <213> Homo sapiens


      <400> 623
 Ala Asp His Ser Phe Tyr Ser Glu Ile Gly Glu Asn Arg Pro Val Gly
   1               5                  10                  15    
 Ala Arg Tyr Ala Gly Ser Asn Thr Ala Leu Leu Leu Phe Ala Thr Leu
              20                  25                  30        





      <210> 624
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 624
 Ala Val Asp Cys Arg Ala Ala Leu Ser His Trp His Ser Glu Val Leu
   1               5                  10                  15    
 Leu Ser Pro Cys Leu Gly Thr Ala Gly Thr Cys Leu Ala Thr Ser Ser
              20                  25                  30        
 Gly Gly Pro Arg Pro Pro Ser Ser Ser Leu Pro Ser Phe Leu Leu Pro
          35                  40                  45            
 Cys Pro Ile Ser Ala Ala Pro Arg Ser Thr Pro Pro Ser Ala Met Ala
      50                  55                  60                
 Pro Arg Lys Gly Ser Ser Arg Val Ala Lys Thr Asn Ser Leu Arg Arg
  65                  70                  75                  80
 Arg Lys Leu Ala Ser Phe Leu Lys Asp Phe Asp Arg Glu Val Glu Ile
                  85                  90                  95    
 Arg Ile Lys Gln Ile Glu Ser Asp Arg Gln Asn Leu Leu Lys Glu Val
             100                 105                 110        
 Asp Asn Leu Tyr Asn Ile Glu Ile Leu Arg Leu
         115                 120            



      <210> 625
      <211> 152
      <212> PRT
      <213> Homo sapiens


      <400> 625
 Asp Glu Ser Ala Gly Ile Cys Gly Asn Lys Met Glu Asp Ser Ala Ser
   1               5                  10                  15    
 Ala Ser Leu Ser Ser Ala Ala Ala Thr Gly Thr Ser Thr Ser Thr Pro
              20                  25                  30        
 Ala Ala Pro Thr Ala Arg Lys Gln Leu Asp Lys Glu Gln Asp Arg Lys
          35                  40                  45            
 Ala Val Asp Ala Leu Leu Thr His Cys Lys Ser Arg Lys Asn Asn Tyr
      50                  55                  60                
 Gly Leu Leu Leu Asn Glu Asn Glu Ser Leu Phe Leu Met Gly Arg Leu
  65                  70                  75                  80
 Trp Lys Ile Pro Ser Lys Glu Leu Arg Val Arg Leu Thr Leu Pro His
                  85                  90                  95    
 Ser Ile Arg Ser Asp Ser Glu Asp Ile Leu Leu Phe Thr Lys Asp Glu
             100                 105                 110        
 Pro Asn Ser Thr Pro Gly Lys Thr Glu Gln Val Tyr Arg Lys Val Leu
         115                 120                 125            
 Asn Lys His Gly Ile Lys Thr Arg Ser Gln Ile Ile Ser Leu Gln Thr
     130                 135                 140                
 Leu Lys Lys Gly Tyr Leu Ser
 145                 150    



      <210> 626
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 626
 Asp His Pro Leu His His Leu Gly Thr Met Gly Ala Ser Pro Arg Arg
   1               5                  10                  15    
 Gly Pro Gly Val Leu Gly Ile Gln Arg Pro Gly Leu Phe Phe Leu Pro
              20                  25                  30        
 Asp Leu Pro Ser Ala Pro Phe Val Pro Arg Asp Ala Gln Arg His Asp
          35                  40                  45            
 Val Glu Leu Leu Glu Ser Ser Phe Pro Ala Ile Leu Arg Asp Phe Gly
      50                  55                  60                
 Ala Gly Ser Trp Asp Phe Ser Gly Thr Thr Pro Pro Pro Arg Gly Trp
  65                  70                  75                  80
 Ala Pro Pro Leu Ala Pro Gly Cys Tyr Gln Leu Leu Leu Tyr Gln Ala
                  85                  90                  95    
 Gly Arg Cys Gln Pro Ser Asn Cys Arg Arg Cys Pro Gly Ala Tyr Arg
             100                 105                 110        
 Ala Leu Arg Gly Leu Arg Asn Phe Met Ser Ala Asn Thr Phe Gly Asn
         115                 120                 125            
 Ala Gly Phe Ser Val Leu Leu Pro Gly Ala Pro Leu Glu Gly Arg Cys
     130                 135                 140                
 Gly Pro Thr Asn Ala Arg Val Arg Ser His Val Gly Leu Lys Ile Pro
 145                 150                 155                 160
 Ser Gly
        



      <210> 627
      <211> 72
      <212> PRT
      <213> Homo sapiens


      <400> 627
 Trp Ser Tyr Cys Ile Pro Asp Lys Met Lys Asp Ala Ile Ile Ala Lys
   1               5                  10                  15    
 Leu Ala Asn Gln Ala Ala Asp Tyr Phe Gly Asp Ala Phe Lys Gln Cys
              20                  25                  30        
 Gln Tyr Lys Asp Thr Leu Pro Lys Val Ser Tyr Cys Phe Tyr Lys His
          35                  40                  45            
 Leu Leu Thr Leu His Val Lys Tyr Leu Asp Phe Phe Val Tyr Lys Lys
      50                  55                  60                
 Gln Val Glu Thr Tyr Lys Glu Ile
  65                  70        



      <210> 628
      <211> 37
      <212> PRT
      <213> Homo sapiens


      <400> 628
 Ser Asn Phe Ile Met Tyr Leu Thr Asp Lys Ala Thr Asp Pro Ser Met
   1               5                  10                  15    
 Ser Glu Gln Asp Trp Ser Ala Ile Gln Asn Phe Cys Glu Gln Val Asn
              20                  25                  30        
 Thr Asp Pro Asn Gly
          35        



      <210> 629
      <211> 59
      <212> PRT
      <213> Homo sapiens


      <400> 629
 Glu Val Phe Met His Gln Val Ser Leu Asn Arg His Met Arg Ser His
   1               5                  10                  15    
 Thr Glu Gln Lys Pro Asn Glu Cys His Glu Tyr Gly Glu Lys Pro His
              20                  25                  30        
 Lys Cys Lys Glu Cys Gly Lys Thr Phe Thr Arg Ser Ser Ser Ile Arg
          35                  40                  45            
 Thr His Glu Arg Ile Tyr Thr Gly Glu Lys Leu
      50                  55                



      <210> 630
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 630
 Leu Lys Glu Ala Arg Gly Lys Ile Asp Met Leu Gln Ala Glu Glu Thr
   1               5                  10                  15    
 Ala Leu Lys Thr Leu Asp Ile Thr Ser Thr Pro Ala Ser Pro Asn Arg
              20                  25                  30        
 Glu Leu His Pro Gln Leu Leu Ser Pro Thr Lys Ala Gly Pro Arg Lys
          35                  40                  45            
 Gly His Ser Arg His Lys Ser Thr Ser Ser Thr Leu Cys His Ala Val
      50                  55                  60                
 Cys Pro Ala Ala Gly His Thr Leu Thr Pro Asn Arg Glu Gly Lys Glu
  65                  70                  75                  80
 Val Asp Thr Ile Leu Phe Ala Glu Phe Gln Ala Trp Arg Glu Ser Pro
                  85                  90                  95    
 Thr Leu Asp Lys Thr Cys Pro Phe Leu Glu Arg Val Tyr Arg Glu Asp
             100                 105                 110        
 Val Gly Pro Cys Leu Asp Phe Thr Met
         115                 120    



      <210> 631
      <211> 89
      <212> PRT
      <213> Homo sapiens


      <400> 631
 Ala Leu Lys Thr Phe Leu Leu Leu Gln Leu Lys Glu Lys Arg Lys Arg
   1               5                  10                  15    
 Lys Gly Lys Gly Met Lys Ser Lys Pro Lys Asp Lys Asp Ser Lys Lys
              20                  25                  30        
 Thr Lys Thr Cys Ser Lys Leu Lys Glu Lys Thr Lys Ile Gly Lys Leu
          35                  40                  45            
 Ile Ile Thr Leu Gly Lys Lys Gln Lys Arg Lys Asn Glu Ser Ser Asp
      50                  55                  60                
 Glu Ile Ser Asp Ala Glu Gln Met Pro Gln His Thr Leu Lys Asp Gln
  65                  70                  75                  80
 Asp Ser Gln Lys Arg Arg Ser Asn Arg
                  85                



      <210> 632
      <211> 42
      <212> PRT
      <213> Homo sapiens


      <400> 632
 Glu His Pro Trp Gly Gly Leu Leu Leu Thr Arg Thr Phe Phe Leu His
   1               5                  10                  15    
 Phe Leu Gln Leu Glu Ile Lys Asn His Val Phe Phe Ser Pro Ile Asn
              20                  25                  30        
 Trp Asp Asp Leu Tyr His Lys Arg Leu Thr
          35                  40        



      <210> 633
      <211> 111
      <212> PRT
      <213> Homo sapiens


      <400> 633
 Leu Thr Ser Ser Arg Pro Glu Gly Val Thr Cys Trp Cys Leu Glu Thr
   1               5                  10                  15    
 Leu Glu Gly Ser Arg Trp Pro Lys Gln Arg Cys Gly Trp Asp Leu Glu
              20                  25                  30        
 Gly Met Leu Cys Ser Leu Ser Thr Cys Phe Pro Gly Ser Ser Ser Ser
          35                  40                  45            
 Ala Leu Gly Leu Gln Ser Leu Gly Leu Ser Gly Gln Ala Pro Ser Ser
      50                  55                  60                
 Ser Ser Leu Asp Ala Gly Thr Leu Ser Asp Thr Thr Ala Ser Ala Pro
  65                  70                  75                  80
 Ala Ser Asp Asp Glu Gly Ser Thr Ala Ala Thr Asp Gly Ser Thr Leu
                  85                  90                  95    
 Arg Thr Ser Pro Ala Asp His Gly Gly Ser Val Gly Ser Glu Ser
             100                 105                 110    



      <210> 634
      <211> 119
      <212> PRT
      <213> Homo sapiens


      <400> 634
 Ser Leu Ser Glu Asp Ile Ser Leu Thr Gln Ser Ile Tyr Asp Lys Lys
   1               5                  10                  15    
 Leu Val Leu Met Gln Lys Asn Leu Gln Gly Leu Asp Pro Lys Ala Leu
              20                  25                  30        
 Asn Asn Cys Ser Phe Cys His Glu Ala Gly Gln Leu Gly Pro Glu Ile
          35                  40                  45            
 Arg Lys Leu Gln Glu Glu Leu Glu Gly Ile Gln Lys Leu Leu Leu Ala
      50                  55                  60                
 Gln Glu Val Gln Leu Asp Gln Thr Leu Gln Ala Gln Glu Val Leu Ser
  65                  70                  75                  80
 Thr Thr Ser Arg Gln Ile Ser Gln Glu Met Gly Ser Cys Ser Phe Ser
                  85                  90                  95    
 Ile His Gln Val Asn Gln Ser Leu Gly Leu Phe Leu Ala Gln Val Arg
             100                 105                 110        
 Gly Trp Gln Ala Thr Thr Ala
         115                



      <210> 635
      <211> 125
      <212> PRT
      <213> Homo sapiens


      <400> 635
 Ala Leu Lys Val Gln Phe Lys Arg Glu Tyr Gly Phe Ile Ser Gln Thr
   1               5                  10                  15    
 Leu Gln Glu Glu Arg Tyr Arg Tyr Glu Arg Leu Glu Asp Gln Leu His
              20                  25                  30        
 Asp Leu Thr Asp Leu His Gln His Glu Thr Ala Asn Leu Lys Gln Glu
          35                  40                  45            
 Leu Ala Ser Ile Glu Glu Lys Val Ala Tyr Gln Ala Tyr Glu Arg Ser
      50                  55                  60                
 Arg Asp Ile Gln Glu Ala Leu Glu Ser Cys Gln Thr Arg Ile Ser Lys
  65                  70                  75                  80
 Leu Glu Leu His Gln Gln Glu Gln Gln Ala Leu Gln Thr Asp Thr Val
                  85                  90                  95    
 Asn Ala Lys Val Leu Leu Gly Arg Cys Ile Asn Val Ile Leu Ala Phe
             100                 105                 110        
 Met Thr Val Ile Leu Val Cys Val Ser Thr Thr Met Tyr
         115                 120                 125



      <210> 636
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 636
 Arg Thr Leu Asn Lys Cys Gln Ala Ser Thr Arg Ala Arg Thr Leu Thr
   1               5                  10                  15    
 Ser Asp Trp Arg Thr Val Gly Ser Gln His Gly Val Thr Val Thr Glu
              20                  25                  30        
 Ser Asp Ser Tyr Ser Ala Ser Leu Ser Gln Asp Thr Asp Lys Gly Arg
          35                  40                  45            
 Asn Ser Met Val Ser Thr Glu Ser Ala Ser Ser Thr Tyr Glu Glu Leu
      50                  55                  60                
 Ala Arg Ala Tyr Glu His Ala Lys Leu Glu Glu Gln Leu Gln His Ala
  65                  70                  75                  80
 Lys Phe Glu Ile Thr Glu Cys Phe Ile Ser Asp Ser Ser Ser Asp Gln
                  85                  90                  95    
 Met Thr Thr Gly Thr Asn Glu Asn Ala Asp Ser Met Thr Ser Met Ser
             100                 105                 110        
 Thr Pro Ser Glu Pro Gly Ile Cys Arg Tyr Thr Ala Ser Pro Pro Lys
         115                 120                 125            
 Pro His Val
     130    



      <210> 637
      <211> 136
      <212> PRT
      <213> Homo sapiens


      <400> 637
 Met Val Glu Val Ser Ile Val Gln Leu Pro Pro Phe Ser Ile Ser Thr
   1               5                  10                  15    
 Ser Arg Ala Ala Pro Pro Lys Ser Arg Leu Ser Asp Ile Thr Gly Ser
              20                  25                  30        
 Ser Lys Thr Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Glu Pro Pro
          35                  40                  45            
 Lys Ser Pro Pro Glu Arg Ala Val Leu Val Ser Glu Val Thr Thr Thr
      50                  55                  60                
 Ser Ala Leu Val Lys Trp Ser Val Ser Lys Ser Ala Pro Arg Val Lys
  65                  70                  75                  80
 Met Tyr Gln Leu Gln Tyr Asn Cys Ser Asp Asp Glu Val Leu Ile Tyr
                  85                  90                  95    
 Arg Met Ile Pro Ala Ser Asn Lys Ala Phe Val Val Asn Asn Leu Val
             100                 105                 110        
 Ser Gly Thr Gly Tyr Asp Leu Cys Val Leu Ala Met Trp Asn Asp Thr
         115                 120                 125            
 Ala Thr Thr Leu Thr Ala Cys Val
     130                 135    



      <210> 638
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 638
 Leu Lys Arg Thr Leu Ser Lys Glu Ile Leu Phe Arg Glu Leu Glu Val
   1               5                  10                  15    
 Arg Gln Val Ala Leu Arg His Leu Ile His Phe Leu Lys Glu Ile Gly
              20                  25                  30        
 Asp Gln Lys Leu Leu Leu Asp Leu Phe Arg Phe Leu Asp Arg Thr Glu
          35                  40                  45            
 Glu Leu Ala Leu Ser His Tyr Arg Glu His Leu Asn Ile Gln Asp Pro
      50                  55                  60                
 Asp Lys Arg Lys Glu Phe Leu Lys Thr Cys Val Gly Leu Pro Phe Ser
  65                  70                  75                  80
 Ala Glu Asp Ser Ala His Ile Gln Asp His Tyr Thr Leu Leu Glu Arg
                  85                  90                  95    
 Gln Ile Ile Ile Glu Ala Asn Asp Arg His Leu Glu Ser Ala Gly Gln
             100                 105                 110        
 Thr Glu Ile Phe Arg Lys His Pro Arg Lys Ala Ser Ile Ile Asn Ile
         115                 120                 125            
 Thr Arg Glu
     130    



      <210> 639
      <211> 185
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(184)
      <223> Xaa = any amino acid or nothing 


      <400> 639
 Ser Gln His Ser Gly Ser Pro Arg Arg Val Asp His Leu Arg Ser Gly
   1               5                  10                  15    
 Val Xaa Asp Gln Pro Gly Gln His Gly Glu Thr Pro Ser Leu Leu Lys
              20                  25                  30        
 Ile Gln Lys Leu Ala Gly Arg Gly Gly Gly His Leu Xaa Ser Arg Leu
          35                  40                  45            
 Leu Arg Arg Leu Arg Gln Glu Asn Gln Leu Asn Leu Gly Gly Gly Gly
      50                  55                  60                
 Cys Ser Glu Leu Arg Ser Arg His Phe Thr Pro Ala Trp Val Thr Glu
  65                  70                  75                  80
 Arg Asp Ser Ile Ser Lys Lys Ile Lys Glu Leu Pro Val Ser Val Phe
                  85                  90                  95    
 Ala Phe Trp Met Leu Gly Val Ser Gln Leu Ser Tyr Pro Ile Lys Ala
             100                 105                 110        
 Glu Leu Ala Ser Arg Met Pro Glu Pro Glu Leu Cys Gly Ser Ser Leu
         115                 120                 125            
 Glu Val Gln Gln Asp Pro Val Asp Gly Pro Ser Ser Phe Leu Cys Thr
     130                 135                 140                
 Tyr Leu Phe Gly Val Val Leu Lys Thr Leu Pro Cys Gln Leu Ser Leu
 145                 150                 155                 160
 Phe Thr Ala Thr Leu Gly Leu Leu Pro Trp Asp Cys Ala Thr Ser Val
                 165                 170                 175    
 Ser Leu Asp Asn Leu His Ser Ala
             180                



      <210> 640
      <211> 89
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(88)
      <223> Xaa = any amino acid or nothing 


      <400> 640
 Ile Pro Gly Asn Gly Met Val Gly Arg Phe Phe Leu Leu Phe Val Phe
   1               5                  10                  15    
 Tyr Phe Ile Phe Cys Phe Leu Phe Phe Phe Lys Thr Glu Ser His Ser
              20                  25                  30        
 Val Ser Arg Leu Glu Cys Ser Gly Ala Ile Leu Ala His Cys Asn Leu
          35                  40                  45            
 His Leu Pro Gly Ser Ser Asn Ser Pro Ala Thr Ala Ser Xaa Val Ala
      50                  55                  60                
 Gly Ile Thr Gly Val Cys His Gln Ala Gln Val Ile Phe Xaa Ile Ser
  65                  70                  75                  80
 Xaa Xaa Gln Trp Gly Phe His His
                  85            



      <210> 641
      <211> 79
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(75)
      <223> Xaa = any amino acid or nothing 


      <400> 641
 Gly Phe Asp Ile Gln Phe Phe Phe Phe Xaa Asp Arg Ile Ser Leu Cys
   1               5                  10                  15    
 His Pro Gly Xaa Ser Pro Ile Pro Gln Ser Trp Leu Thr Ala Ala Thr
              20                  25                  30        
 Thr Ser Xaa Val Lys Xaa Ser Ser His Leu Ser Leu Pro Ser Ser Xaa
          35                  40                  45            
 Asp Tyr Arg Ser Thr Pro Pro His Leu Ala Asn Phe Cys Ile Phe Cys
      50                  55                  60                
 Gly Asn Arg Val Phe Ser Met Leu Pro Arg Val
  65                  70                  75



      <210> 642
      <211> 300
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(294)
      <223> Xaa = any amino acid or nothing 


      <400> 642
 Arg Asn Arg Leu Ala Ser Ala Ala Met Ala Ala Phe Val Pro Cys Ala
   1               5                  10                  15    
 Leu Asp Thr Ser Cys Ser Ser Val Phe Ser Gly Asp Gln Leu Val Gln
              20                  25                  30        
 His Ile Leu Gly Thr Glu Asp Leu Ile Val Glu Val Thr Ser Asn Asp
          35                  40                  45            
 Ala Glu Arg Phe Tyr Pro Trp Thr Ile Asp Asn Lys Tyr Tyr Ser Ala
      50                  55                  60                
 Asp Ile Asn Leu Cys Val Val Pro Asn Lys Phe Leu Val Thr Ala Glu
  65                  70                  75                  80
 Ile Ala Glu Ser Val Gln Ala Phe Val Val Tyr Phe Asp Ser Thr Gln
                  85                  90                  95    
 Lys Ser Gly Leu Asp Ser Val Ser Ser Trp Leu Pro Leu Ala Lys Ala
             100                 105                 110        
 Trp Leu Pro Glu Val Met Ile Leu Val Cys Asp Xaa Ser Val Cys Glu
         115                 120                 125            
 Asp Gly Ile Asn Arg Gln Lys Gly Gln Glu Trp Cys Ile Lys His Gly
     130                 135                 140                
 Phe Glu Leu Val Glu Leu Ser Pro Glu Glu Leu Pro Glu Glu Asp Asp
 145                 150                 155                 160
 Asp Phe Pro Glu Ser Thr Gly Val Lys Arg Ile Val Gln Ala Leu Asn
                 165                 170                 175    
 Ala Asn Val Trp Ser Asn Val Val Met Lys Asn Asp Arg Asn Gln Gly
             180                 185                 190        
 Phe Ser Leu Leu Asn Ser Leu Thr Gly Thr Asn His Ser Ile Gly Ser
         195                 200                 205            
 Ala Asp Pro Cys His Pro Glu Gln Pro His Leu Pro Ala Ala Asp Ser
     210                 215                 220                
 Thr Glu Ser Leu Ser Asp His Arg Gly Gly Ala Ser Asn Thr Thr Asp
 225                 230                 235                 240
 Ala Gln Val Asp Ser Ile Val Asp Pro Met Leu Gly Ser Gly Ile Phe
                 245                 250                 255    
 Gln Gly Ile Arg Pro Val Phe Thr Met Gly Gly Arg Glu Met Trp Glu
             260                 265                 270        
 Ile Phe Glu Arg Leu Phe Ser Lys Phe Lys Gly Asn Xaa Lys Asp Lys
         275                 280                 285            
 Gly Leu Arg Arg Phe Pro
     290                



      <210> 643
      <211> 151
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(151)
      <223> Xaa = any amino acid or nothing 


      <400> 643
 Lys Asn Pro Thr Ala Tyr Ala Lys Leu Gly Thr Arg Arg Ala Ala Pro
   1               5                  10                  15    
 Gly Ala Asn Met Pro Arg Tyr Ala Leu Leu Val Leu Gly Pro Ala Gly
              20                  25                  30        
 Ser Gly Lys Ser Thr Tyr Cys Ala Thr Met Val His His Cys Glu Ala
          35                  40                  45            
 Leu Asn Arg Ser Val Gln Val Val Asn Leu Asp Pro Ala Ala Glu His
      50                  55                  60                
 Phe Asn Tyr Ser Val Met Ala Asp Ile Arg Glu Leu Ile Glu Ala Asp
  65                  70                  75                  80
 Asp Val Met Glu Asp Asp Ser Leu Arg Leu Gly Pro Asn Gly Gly Leu
                  85                  90                  95    
 Val Phe Cys Met Glu Tyr Phe Ala Asn Asn Phe Asp Trp Leu Glu Asn
             100                 105                 110        
 Cys Leu Gly His Val Gln Asp Asp Tyr Ile Leu Phe Asp Cys Pro Gly
         115                 120                 125            
 Gln Ile Glu Leu His Thr His Leu Pro Val Met Asn Gln Leu Asp Gln
     130                 135                 140                
 Gln Leu Xaa Gln Arg Glu Phe
 145                 150    



      <210> 644
      <211> 123
      <212> PRT
      <213> Homo sapiens


      <400> 644
 Lys Leu Leu Phe Gly Lys Leu Gln Leu Arg Ile Ser Arg Gly Ser Arg
   1               5                  10                  15    
 His Ile Pro Leu Thr Tyr Ile Asp Leu Cys Pro Thr Ser Val Ser Cys
              20                  25                  30        
 Gly Asp Val Leu Tyr Leu Pro Thr Ser Ser Gln Asp His Thr Trp Val
          35                  40                  45            
 Thr Asp Asn Cys Gln Glu Thr Cys Gly Glu Pro Thr Ser Cys Gln Pro
      50                  55                  60                
 Val His Cys Glu Thr Gly Asn Leu Glu Thr Ser Cys Gly Ser Ser Thr
  65                  70                  75                  80
 Ala Tyr Tyr Val Pro Arg Pro Cys Gln Gly Ser Ser Phe Leu Pro Ala
                  85                  90                  95    
 Ser Phe Phe Ser Ser Ser Cys Leu Pro Val Ser Cys Arg Pro Gln Arg
             100                 105                 110        
 Tyr Val Ser Ser Gly Cys Arg Pro Leu Met Pro
         115                 120            



      <210> 645
      <211> 122
      <212> PRT
      <213> Homo sapiens


      <400> 645
 Asn Leu Ala Leu Gly Met Val Met Trp Asn Arg Pro Cys Gln Arg Gly
   1               5                  10                  15    
 Ala Gln Gln Pro Val Val Gly Glu Pro Thr Ala Glu Gly Glu Pro His
              20                  25                  30        
 Leu Pro Thr Gly Arg Glu Leu Thr Glu Ala Asn Arg Phe Ala Tyr Ala
          35                  40                  45            
 Ala Leu Cys Gly Ile Ser Leu Ser Gln Ile Phe Pro Glu Pro Glu His
      50                  55                  60                
 Ser Ser Phe Cys Thr Glu Phe Met Ala Gly Leu Glu Lys Trp Leu Glu
  65                  70                  75                  80
 Leu Ser Glu Thr Val Leu Pro Thr Met Thr Ala Phe Ala Ser Gly Leu
                  85                  90                  95    
 Gly Gly Glu Gly Thr Asp Val Ser Val Gln Thr Leu Leu Lys Asp Pro
             100                 105                 110        
 Ile Leu Lys Asp Asp Pro Thr Gly Ile Thr
         115                 120        



      <210> 646
      <211> 198
      <212> PRT
      <213> Homo sapiens


      <400> 646
 Trp Glu Gly Arg Met Ala Ala Pro Gly Leu Arg Leu Gly Ala Gly Arg
   1               5                  10                  15    
 Leu Phe Glu Met Pro Ala Val Leu Glu Arg Leu Ser Arg Tyr Asn Ser
              20                  25                  30        
 Thr Ser Gln Ala Phe Ala Glu Val Leu Arg Leu Pro Lys Gln Gln Leu
          35                  40                  45            
 Arg Lys Leu Leu Tyr Pro Leu Gln Glu Val Glu Arg Phe Leu Ala Pro
      50                  55                  60                
 Tyr Gly Arg Gln Asp Leu His Leu Arg Ile Phe Asp Pro Ser Pro Glu
  65                  70                  75                  80
 Asp Ile Ala Arg Ala Asp Asn Ile Phe Thr Ala Thr Glu Arg Asn Arg
                  85                  90                  95    
 Ile Asp Tyr Val Ser Ser Ala Val Arg Ile Asp His Ala Pro Asp Leu
             100                 105                 110        
 Pro Arg Pro Glu Val Cys Phe Ile Gly Arg Ser Asn Val Gly Lys Ser
         115                 120                 125            
 Ser Leu Ile Lys Ala Leu Phe Ser Leu Ala Pro Glu Val Glu Val Arg
     130                 135                 140                
 Val Ser Lys Lys Pro Gly His Thr Lys Lys Met Asn Phe Phe Lys Val
 145                 150                 155                 160
 Gly Lys His Phe Thr Val Val Asp Met Pro Gly Tyr Gly Phe Arg Ala
                 165                 170                 175    
 Pro Glu Asp Phe Val Asp Met Val Glu Thr Tyr Leu Lys Glu Arg Arg
             180                 185                 190        
 Asn Leu Lys Arg Thr Phe
         195            



      <210> 647
      <211> 143
      <212> PRT
      <213> Homo sapiens


      <400> 647
 Asn Gly Arg Arg Arg Thr Thr Thr Arg Leu Gly Arg Pro Trp Cys Tyr
   1               5                  10                  15    
 Pro Thr Tyr Leu Ser Cys Cys Pro Arg Ile Val Gln Ser Asn Asp Leu
              20                  25                  30        
 Thr Glu Ala Ala Tyr Ser Leu Ser Arg Asp Gln Lys Arg Met Leu Tyr
          35                  40                  45            
 Leu Phe Val Asp His Ile Arg Lys Ser Asp Gly Ala Leu Gln Glu His
      50                  55                  60                
 Asp Gly Ile Cys Glu Ile His Val Ala Lys Tyr Ala Glu Ile Phe Gly
  65                  70                  75                  80
 Leu Thr Ser Ala Glu Ala Ser Lys Asp Ile Arg Asp Ala Leu Lys Ser
                  85                  90                  95    
 Phe Ala Gly Lys Glu Gly Val Phe Tyr Arg Pro Glu Glu Asp Ala Gly
             100                 105                 110        
 Asp Glu Lys Ser Tyr Glu Phe Phe Pro Trp Phe Ile Lys Arg Ala His
         115                 120                 125            
 Ser Pro Ser Arg Gly Leu Tyr Arg Val His Asn His Ser Tyr Leu
     130                 135                 140            



      <210> 648
      <211> 33
      <212> PRT
      <213> Homo sapiens


      <400> 648
 Val Met Ala Glu Thr Ala Val Ile Asn His Lys Lys Arg Lys Asn Ser
   1               5                  10                  15    
 Pro Arg Ile Val Gln Ser Asn Asp Leu Thr Glu Ala Ala Tyr Ser Leu
              20                  25                  30        
 Ser
    



      <210> 649
      <211> 73
      <212> PRT
      <213> Homo sapiens


      <400> 649
 Gly Val Met Ala Ser Asp Ala Ser His Ala Leu Glu Ala Ala Leu Glu
   1               5                  10                  15    
 Leu Met Asp Gly Ile Ile Ala Cys Thr Lys Thr Gly Ala Asp Leu Ser
              20                  25                  30        
 Asp Gly Thr Cys Glu Pro Gly Leu Ala Ser Pro Ala Phe Tyr Met Asn
          35                  40                  45            
 Pro Phe Pro Val Leu His Leu Ile Glu Asp Leu Arg Leu Ala Leu Glu
      50                  55                  60                
 Met Leu Glu Leu Pro Gln Glu Arg Ala
  65                  70            



      <210> 650
      <211> 152
      <212> PRT
      <213> Homo sapiens


      <400> 650
 Gly Thr Ser Gly Ser Thr Ile Ser Ser Gly Gly Pro Ala Glu Glu Arg
   1               5                  10                  15    
 Tyr Trp Gly Gly Gly Ala Ala Val Phe Arg Ala Met Ile Pro Pro Gln
              20                  25                  30        
 Glu Ala Ser Ala Arg Arg Arg Glu Asn Glu Asp Lys Leu Lys Gln Glu
          35                  40                  45            
 Glu Glu Thr Leu Ser Phe Ile Arg Asp Ser Leu Glu Lys Ser Asp Gln
      50                  55                  60                
 Leu Thr Lys Asn Met Val Ala Ile Val Ser Ser Phe Glu Ser Arg Leu
  65                  70                  75                  80
 Met Lys Leu Glu Asn Ser Ile Ile Pro Val His Lys Gln Thr Glu Asn
                  85                  90                  95    
 Leu Gln Arg Leu Gln Glu Asn Val Glu Lys Thr Leu Thr Cys Leu Asp
             100                 105                 110        
 His Val Ile Ser Tyr Tyr His Val Ala Arg Asp Thr Glu Lys Ile Ile
         115                 120                 125            
 Thr Glu Gly Pro Thr Gly Arg Leu Glu Glu Tyr Leu Gly Ser Met Val
     130                 135                 140                
 Lys Ile Gln Lys Ala Val Glu Tyr
 145                 150        



      <210> 651
      <211> 135
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(134)
      <223> Xaa = any amino acid or nothing 


      <400> 651
 Ser Leu Gln Ser His Glu Pro Ile Lys Pro Leu Phe Phe Thr Asp Tyr
   1               5                  10                  15    
 Pro Val Leu Trp Ile Met Ser Ser Gly Asp Arg Asp His Pro Gly Ser
              20                  25                  30        
 Tyr Gly Glu Thr Pro Phe Leu Leu Lys Ile Lys Lys Leu Ala Arg His
          35                  40                  45            
 Gly Gly Gly Arg Leu Xaa Ser Gln Leu Leu Gly Arg Leu Arg Gln Glu
      50                  55                  60                
 Asn Gly Met Asn Pro Gly Gly Gly Gly Cys Ile Glu Pro Arg Ser Arg
  65                  70                  75                  80
 His Cys Thr Pro Ala Trp Ala Thr Glu Gln Gly Ser Val Ser Lys Lys
                  85                  90                  95    
 Thr Pro Lys Asn Gln Lys Thr Lys Leu Pro Ser Leu Arg Tyr Phe Phe
             100                 105                 110        
 Ile Ala Ile Gln Glu Arg Pro Asn Thr Met Gly Ser Gln His Ile Lys
         115                 120                 125            
 His Thr Ala Ala Thr Lys
     130                



      <210> 652
      <211> 91
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(89)
      <223> Xaa = any amino acid or nothing 


      <400> 652
 Arg Gln Leu Gln Ser Phe Met Met Phe Pro Leu Ala Arg Asn Ala Leu
   1               5                  10                  15    
 Ser Ser Leu Lys Ile Gln Ser Ile Leu Gln Ser Met Ala Arg Gln Xaa
              20                  25                  30        
 Ala Met Lys Thr Leu Ser Pro Asp Phe His Asp Lys Tyr Gly Asn Ala
          35                  40                  45            
 Val Leu Ala Ser Gly Thr Ala Phe Leu Cys Cys Ile Thr Trp Val Phe
      50                  55                  60                
 Thr Ala Thr Gln Ile Gly Ile Glu Trp Asn Leu Ser Pro Val Gly Arg
  65                  70                  75                  80
 Val Thr Pro Lys Glu Trp Lys His Gln
                  85                



      <210> 653
      <211> 299
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(288)
      <223> Xaa = any amino acid or nothing 


      <400> 653
 Arg Glu Arg Glu Thr Asp Val His Gly Met Ala Thr Gly Thr Arg Tyr
   1               5                  10                  15    
 Ala Gly Lys Val Ala Val Val Thr Gly Gly Gly Arg Gly Ile Gly Ala
              20                  25                  30        
 Gly Ile Val Arg Ala Phe Val Asn Ser Gly Ala Arg Val Val Ile Cys
          35                  40                  45            
 Asp Lys Asp Glu Ser Gly Gly Arg Ala Leu Glu Gln Glu Leu Pro Gly
      50                  55                  60                
 Gly Cys Leu Ile Ser Phe Cys Asp Val Thr Gln Glu Asp Asp Val Lys
  65                  70                  75                  80
 Thr Leu Val Ser Glu Thr Ile Arg Arg Phe Gly Arg Leu Asp Cys Val
                  85                  90                  95    
 Val Asn Asn Ala Gly His His Pro Pro Pro Gln Arg Pro Glu Glu Thr
             100                 105                 110        
 Ser Ala His Gly Phe Arg Gln Leu Leu Glu Leu Asn Leu Leu Gly Thr
         115                 120                 125            
 Tyr Thr Leu Thr Lys Leu Ala Leu Pro Tyr Leu Arg Lys Ser Gln Gly
     130                 135                 140                
 Asn Val Ile Asn Ile Ser Ser Leu Val Gly Ala Ile Gly Gln Ala Gln
 145                 150                 155                 160
 Ala Val Pro Tyr Val Ala Thr Lys Gly Ala Val Thr Ala Met Thr Lys
                 165                 170                 175    
 Ala Leu Ala Leu Asp Glu Ser Pro Tyr Gly Val Arg Val Asn Cys Ile
             180                 185                 190        
 Ser Pro Gly Asn Ile Trp Thr Pro Leu Trp Glu Glu Leu Ala Ala Leu
         195                 200                 205            
 Met Pro Asp Pro Arg Ala Thr Ile Arg Glu Gly Met Leu Ala Gln Gly
     210                 215                 220                
 Arg Ser Gly Val Gln Ile Gln Pro Leu Gly Arg Met Gly Gln Pro Ala
 225                 230                 235                 240
 Glu Val Gly Ala Ala Ala Val Phe Leu Ala Ser Glu Ala Asn Phe Cys
                 245                 250                 255    
 Thr Gly Ile Xaa Leu Leu Val Thr Gly Gly Ala Glu Leu Gly Tyr Gly
             260                 265                 270        
 Cys Lys Ala Ser Arg Ser Thr Pro Val Asp Ala Pro Asp Ile Pro Ser
         275                 280                 285            





      <210> 654
      <211> 292
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(286)
      <223> Xaa = any amino acid or nothing 


      <400> 654
 Lys Cys Leu Lys Gly Met Val Gln Met Gly Gly Ser Phe Gly Tyr Gly
   1               5                  10                  15    
 Pro Lys Met Thr Leu Leu Leu Ser Cys Asn Phe Glu Thr Leu Val Gly
              20                  25                  30        
 Leu Ser Glu Phe Lys Cys Arg Ser Xaa Thr Pro Asp Leu Arg Xaa Ser
          35                  40                  45            
 Thr Cys Leu Ser Leu Pro Lys Cys Trp Asp Tyr Arg Cys Glu Pro Pro
      50                  55                  60                
 Cys Leu Thr Cys Val Ile Val Asn Ile Arg His Leu Pro Pro Asn Thr
  65                  70                  75                  80
 Gly Leu Pro Ser Leu Gly Leu Cys Leu Ser Phe Leu Phe Met Pro Ser
                  85                  90                  95    
 Pro Ser Ala Pro Ser Ile Val Pro Val Leu His Gly Cys Trp Val His
             100                 105                 110        
 Ile Cys Gln Ala Asp Val Tyr His Thr Leu Leu Lys Gly Phe Leu Phe
         115                 120                 125            
 Leu Phe Leu Arg Gln Ser Leu His Ser Val Thr Gln Ala Gly Val Gln
     130                 135                 140                
 Trp Cys His Phe Gly Ser Leu Gln Arg Phe Leu Pro Pro Gly Phe Lys
 145                 150                 155                 160
 Arg Phe Ser Cys Leu Ile Leu Leu Ser Ser Trp Asp Tyr Arg His Leu
                 165                 170                 175    
 Pro Pro Arg Gln Ala Asn Phe Cys Ile Phe Met Xaa Arg Trp Gly Phe
             180                 185                 190        
 Thr Met Phe Ala Arg Leu Val Ser Asn Ser Xaa Pro Gln Cys Asp Pro
         195                 200                 205            
 Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Met Ser His His
     210                 215                 220                
 Ala Gln Pro Pro Ala Gln Ile Phe Ile Ser Gly Ala Phe Met Arg Val
 225                 230                 235                 240
 Ser Glu Leu Ile Phe Val Ser Trp Pro Asp Leu Ala Asn Leu Pro Gln
                 245                 250                 255    
 Pro Arg Xaa Pro Ser Leu Gln Glu Met Val Cys Glu Asn Ala Xaa Arg
             260                 265                 270        
 Glu Trp Ser Lys Trp Glu Ala Ala Leu Gly Met Ala Pro Lys
         275                 280                 285    



      <210> 655
      <211> 290
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(288)
      <223> Xaa = any amino acid or nothing 


      <400> 655
 Arg Gly Ala Ala Ser Leu Gly Val Val Phe Ile Leu Gly Glu Gly Ser
   1               5                  10                  15    
 Val Glu Cys Glu Gly Arg Trp Arg Arg Trp Arg Arg Gln Pro Gly Glu
              20                  25                  30        
 Asp Gly Ala Ser Gly Gln Glu Arg Gly Gln Arg Gly Cys Glu His Tyr
          35                  40                  45            
 Asp Arg Gly Cys Leu Leu Lys Ala Pro Cys Cys Asp Lys Leu Tyr Thr
      50                  55                  60                
 Cys Arg Leu Cys His Asp Asn Asn Glu Asp His Asn Leu Asp Arg Phe
  65                  70                  75                  80
 Lys Val Lys Glu Val Gln Cys Ile Asn Cys Glu Lys Ile Gln His Ala
                  85                  90                  95    
 Gln Gln Thr Cys Glu Glu Cys Ser Thr Leu Phe Gly Glu Tyr Tyr Cys
             100                 105                 110        
 Asp Ile Cys His Leu Phe Asp Lys Asp Lys Lys Gln Tyr His Cys Glu
         115                 120                 125            
 Asn Cys Gly Asn Leu Xaa Glu Phe Gly Pro Lys Glu Gly Phe Phe Pro
     130                 135                 140                
 Cys Leu Glu Met Leu Thr Tyr Gly Leu Ala Met Asn Leu Gln Gly Arg
 145                 150                 155                 160
 His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn Cys Pro Ile Cys Leu
                 165                 170                 175    
 Glu Asp Ile His Thr Ser Arg Val Val Ala His Val Leu Pro Cys Gly
             180                 185                 190        
 His Leu Leu His Arg Thr Cys Tyr Glu Glu Met Leu Lys Glu Gly Tyr
         195                 200                 205            
 Arg Cys Pro Leu Cys Met His Ser Ala Leu Asp Met Thr Arg Tyr Trp
     210                 215                 220                
 Arg Gln Leu Asp Asp Glu Val Ala Gln Thr Pro Met Pro Ser Glu Tyr
 225                 230                 235                 240
 Gln Asn Met Thr Val Asp Ile Leu Cys Asn Asp Cys Asn Gly Arg Ser
                 245                 250                 255    
 Thr Val Gln Phe His Ile Leu Gly Met Lys Cys Lys Ile Cys Glu Ser
             260                 265                 270        
 Tyr Asn Thr Ala Gln Ala Gly Gly Arg Arg Ile Ser Leu Asp Gln Gln
         275                 280                 285            





      <210> 656
      <211> 261
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(247)
      <223> Xaa = any amino acid or nothing 


      <400> 656
 Ser Ala Thr Leu Arg Gly Phe Val Phe Gln Pro Asn Leu Ala Arg Pro
   1               5                  10                  15    
 Leu Phe Leu Ser Pro Cys Ser Pro Met Glu Leu Lys Asn Leu Glu Tyr
              20                  25                  30        
 Arg Pro Val Lys Val Arg Gly Cys Phe Asp His Ser Lys Glu Leu Tyr
          35                  40                  45            
 Met Met Pro Arg Thr Met Gly Gly Pro Cys Arg Glu Ala Arg Glu Gly
      50                  55                  60                
 Gly Leu Ile Ser Ser Ser Thr Gln Ser Gly Ala Tyr Val Val Thr Pro
  65                  70                  75                  80
 Phe His Cys Thr Asp Leu Gly Val Thr Ile Leu Val Lys Xaa Arg Gly
                  85                  90                  95    
 Ser Phe Pro Arg Lys Lys Val Asn Pro Xaa Asn Pro Gly Arg Lys Ala
             100                 105                 110        
 Gln Ile Glu Gly Glu Val Asp Leu Ile Gly Met Val Arg Leu Asp Ser
         115                 120                 125            
 Lys Pro Gly Gln Pro Phe Val Pro Glu Asn Asn Pro Glu Arg Asn His
     130                 135                 140                
 Trp Pro Tyr Arg Tyr Leu Glu Ala Met Ala Arg Ile Thr Gly Ala Glu
 145                 150                 155                 160
 Pro Ile Phe Ile Asp Ala Asn Phe Gln Ser Thr Val Pro Gly Gly Pro
                 165                 170                 175    
 Ile Gly Gly Gln Thr Arg Val Thr Leu Arg Asn Glu His Leu Gln Tyr
             180                 185                 190        
 Ile Val Thr Trp Tyr Gly Leu Ser Ala Ala Thr Ser Tyr Leu Trp Phe
         195                 200                 205            
 Lys Lys Phe Leu Arg Gly Thr Thr Trp Cys Val Asp Arg Ser Ala Ala
     210                 215                 220                
 Glu Ala Leu Ser Leu Asp Asn Cys Ser Ile Ser Arg Leu Pro Leu Cys
 225                 230                 235                 240
 Trp Ile Met Cys Tyr Trp Val
                 245        



      <210> 657
      <211> 525
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(503)
      <223> Xaa = any amino acid or nothing 


      <400> 657
 Ile Ala Ser Gly Arg Ser Arg Ser Ile Met Pro Leu Leu Lys Gln Pro
   1               5                  10                  15    
 Ser Arg Pro Leu Gly Thr Ala Asp Pro Ser Gln Ala Thr Gly Ile Asp
              20                  25                  30        
 Trp Ser Cys Pro Trp Gly Cys Asn Trp Pro Gln Leu Ser Arg Ala Asn
          35                  40                  45            
 Thr Glu Val Asn Tyr Lys Pro Gln Ala Pro Ser Pro Ala Ser Val His
      50                  55                  60                
 Ser Cys Pro Val Ala Gly Met Ala Val Ala Phe Leu Val Ala Arg Pro
  65                  70                  75                  80
 Lys Pro Val Gly Tyr Thr Lys Ala Glu Glu Pro Ile Ala Met Arg Ser
                  85                  90                  95    
 Leu Gly Ala Leu Leu Leu Leu Leu Ser Ala Cys Leu Ala Gly Ser Ala
             100                 105                 110        
 Cys Pro Val Pro Thr Pro Ala Glu Asn Ile Gln Val Gln Glu Asn Phe
         115                 120                 125            
 Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Gly His Arg Phe
     130                 135                 140                
 Pro Pro Cys Pro Trp Leu Xaa Glu Arg Ser Trp Asp Arg Met Thr Val
 145                 150                 155                 160
 Ser Thr Leu Val Leu Arg Glu Arg Ala Leu Thr Glu Ala Glu Ile Ser
                 165                 170                 175    
 Met Thr Ser Thr Arg Trp Arg Gly Lys Gly Val Leu Val Glu Glu Thr
             180                 185                 190        
 Ser Leu Glu Leu Tyr Xaa Arg Lys Thr Asp Thr Xaa Leu Gly Lys Phe
         195                 200                 205            
 Leu Ser Tyr His Lys Ser Lys Trp Asn Ile Thr Met Glu Ser Tyr Val
     210                 215                 220                
 Val His Thr Asn Tyr Asp Glu Tyr Ala Ile Phe Leu Asp Thr Arg Asn
 225                 230                 235                 240
 Phe Ser Arg His His Gly Pro Thr Phe Ile Ala Lys Phe Tyr Gly Arg
                 245                 250                 255    
 Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp Phe Arg Val Val Ala
             260                 265                 270        
 Gln Gly Leu Gly Ile Pro Glu Asp Ser Leu Phe Thr Met Ala Asp Arg
         275                 280                 285            
 Gly Glu Cys Val Pro Gly Gly Ala Gly Thr Lys Lys Pro Ser Leu Ile
     290                 295                 300                
 Pro Arg Val Arg Arg Leu Val Ala Tyr Pro Lys Lys Glu Gly Arg Ile
 305                 310                 315                 320
 Gln Gly Gly Gly Gln Leu Val Asn Xaa Lys Ser Pro Arg Lys Glu Gly
                 325                 330                 335    
 Phe Pro Cys Gln Leu Gly Leu Leu Arg Pro Val Pro Cys Asn Gly Lys
             340                 345                 350        
 Xaa Pro Ser Arg Xaa Phe Pro Asn Asn Gly Asn Ile Pro Trp Pro Cys
         355                 360                 365            
 Glu Glu Leu Ser Gln Tyr Gly Gly Cys Met Gly Gln Arg Val Asn Asn
     370                 375                 380                
 Phe Arg Gln Gln Glu Lys Glu Cys Leu Gln Thr Cys Arg Thr Cys Gly
 385                 390                 395                 400
 Arg Pro Cys Asn Leu Pro His Ser Pro Gly Gly Pro Cys Arg Ala Phe
                 405                 410                 415    
 Ile Gln Leu Trp Gly Ile Xaa Cys Cys Ser Arg Gly Lys Cys Val Leu
             420                 425                 430        
 His Ser Pro Tyr Gly Gly Leu Ala Arg Gly Asn Gly Asn Lys Phe Tyr
         435                 440                 445            
 Ser Glu Lys Glu Cys Arg Glu Tyr Cys Gly Val Pro Gly Asp Gly Asp
     450                 455                 460                
 Glu Glu Leu Leu Arg Phe Cys Gln Leu Thr Thr Gly Arg Ser Ala Lys
 465                 470                 475                 480
 Ser Glu Asp Gly Gln Cys Leu Ser Arg Gly Pro Val Ala Gly Lys Arg
                 485                 490                 495    
 Gln Ser Asn Leu Gly Ser Lys
             500            



      <210> 658
      <211> 675
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(664)
      <223> Xaa = any amino acid or nothing 


      <400> 658
 Pro Cys Gly Ser Gly Ile Pro Ser His Gly Arg Phe Leu Arg Ala Ala
   1               5                  10                  15    
 Gly Gln Arg Pro Ala Cys Ala Ala Pro Val Val Pro Ser Cys Trp Asp
              20                  25                  30        
 Pro Ala Met Gln Thr Pro Pro Leu Gln Gln Pro His Gln Glu Gln Val
          35                  40                  45            
 Phe Leu Ala Phe Leu Val Ile Val Ile Pro Ser Phe Leu Thr Lys Glu
      50                  55                  60                
 Val Phe Ile Pro Gln Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly
  65                  70                  75                  80
 Pro Thr Val Tyr Asp Ala Ser His Met Gly His Ala Arg Ser Tyr Ile
                  85                  90                  95    
 Ser Phe Asp Ile Leu Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp
             100                 105                 110        
 Val Phe Tyr Cys Met Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys
         115                 120                 125            
 Arg Ala Arg Gln Asn His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro
     130                 135                 140                
 Glu Ala Ala Gln Leu Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe
 145                 150                 155                 160
 Ser Val Lys Leu Asn Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu
                 165                 170                 175    
 Glu Arg Ile Gln His Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys
             180                 185                 190        
 Ala Val Gln Ser Arg Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu
         195                 200                 205            
 Val Leu Leu Glu Glu Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser
     210                 215                 220                
 Thr Leu Gly Cys Asp Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro
 225                 230                 235                 240
 Lys Phe Trp Glu Gly Asp Phe His Arg Asp Met Glu Ala Leu Asn Val
                 245                 250                 255    
 Leu Pro Pro Asp Val Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile
             260                 265                 270        
 Val Asn Phe Val Gln Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser
         275                 280                 285            
 Asn Gly Ser Val Tyr Phe Gly Tyr Ser Gly Ser Phe Ala Ser Ser Glu
     290                 295                 300                
 Lys His Ser Tyr Gly Lys Leu Val Pro Glu Ala Val Gly Asp Gln Lys
 305                 310                 315                 320
 Ala Leu Gln Glu Gly Glu Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu
                 325                 330                 335    
 Ser Glu Lys Arg Ser Pro Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys
             340                 345                 350        
 Pro Gly Glu Pro Ser Trp Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly
         355                 360                 365            
 Trp His Ile Glu Cys Ser Ala Met Ala Gly Thr Leu Leu Gly Ala Ser
     370                 375                 380                
 Met Asp Ile His Gly Gly Gly Phe Asp Leu Arg Phe Pro His His Asp
 385                 390                 395                 400
 Asn Glu Leu Ala Gln Ser Glu Ala Tyr Phe Glu Asn Asp Cys Trp Val
                 405                 410                 415    
 Arg Tyr Phe Leu His Thr Gly His Leu Thr Ile Ala Gly Cys Lys Met
             420                 425                 430        
 Ser Lys Ser Leu Lys Asn Phe Ile Thr Ile Lys Asp Ala Leu Lys Lys
         435                 440                 445            
 His Ser Ala Arg Gln Leu Arg Leu Ala Phe Leu Met His Ser Trp Lys
     450                 455                 460                
 Asp Thr Leu Asp Tyr Ser Ser Asn Thr Met Glu Ser Ala Leu Gln Tyr
 465                 470                 475                 480
 Glu Lys Phe Leu Asn Glu Phe Phe Leu Asn Val Lys Asp Ile Leu Arg
                 485                 490                 495    
 Ala Pro Val Asp Ile Thr Gly Gln Phe Glu Lys Trp Gly Glu Glu Glu
             500                 505                 510        
 Ala Glu Leu Asn Lys Asn Phe Tyr Asp Lys Lys Thr Ala Ile His Lys
         515                 520                 525            
 Ala Leu Cys Asp Asn Val Asp Thr Arg Thr Val Met Glu Glu Met Arg
     530                 535                 540                
 Ala Leu Val Ser Gln Cys Asn Leu Tyr Met Ala Ala Arg Lys Ala Val
 545                 550                 555                 560
 Arg Lys Arg Pro Asn Gln Ala Leu Leu Glu Asn Ile Ala Leu Tyr Leu
                 565                 570                 575    
 Thr His Met Leu Lys Ile Phe Gly Ala Val Glu Glu Asp Ser Ser Leu
             580                 585                 590        
 Gly Phe Pro Val Arg Met Gly Trp Ser Thr Cys Leu Ser Phe Glu Ala
         595                 600                 605            
 Thr Val Met Pro Thr Leu Xaa Val Xaa Ser Gly Phe Arg Glu Gly Val
     610                 615                 620                
 Arg Lys Ile Ala Arg Glu Gln Lys Val Leu Glu Ile Leu Gln Leu Ser
 625                 630                 635                 640
 Asp Ala Leu Arg Thr Thr Ser Cys Pro Ser Leu Gly Cys Gly Leu Lys
                 645                 650                 655    
 Thr Thr Lys Asp Cys Pro Gln Trp
             660                



      <210> 659
      <211> 211
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(199)
      <223> Xaa = any amino acid or nothing 


      <400> 659
 Lys Asn Gly Leu Gln His Glu Leu His Cys Arg Lys Trp Glu Lys Lys
   1               5                  10                  15    
 Gln Asn Gly Lys Gly Lys Lys Val Gln Glu Ala Asp Pro Glu Glu Phe
              20                  25                  30        
 Val Val Glu Lys Val Leu Asp Arg Arg Val Ser Xaa Met Gly Lys Trp
          35                  40                  45            
 Lys Tyr Phe Leu Lys Trp Lys Gly Phe Thr Asp Ala Asp Asn Thr Trp
      50                  55                  60                
 Glu Pro Xaa Arg Lys Ile Xaa Asp Cys Pro Glu Leu Asp Xaa Ser Arg
  65                  70                  75                  80
 Phe Leu Asn Phe Ser Arg Lys Ala Gly Gln Arg Lys Lys Ile Gly Thr
                  85                  90                  95    
 Lys Lys Glu Asn Leu Leu Ser Asp Gln Xaa Ile Trp Ile Asp Gln Pro
             100                 105                 110        
 Asn Ser Xaa Lys Lys Lys Arg Cys Cys Xaa Pro Thr Gln Arg Gly Phe
         115                 120                 125            
 Ala Pro Glu Val Leu Ile Pro Glu Arg Ile Ile Trp Val Pro Pro Asp
     130                 135                 140                
 Ser Gln Leu Glu Asn Leu Met Phe Leu Met Glu Met Glu Lys Ile Pro
 145                 150                 155                 160
 Asp Glu Ala Asp Leu Val Pro Gly Arg Lys Glu Ala His Met Lys Cys
                 165                 170                 175    
 Pro Gln Ile Val Ile Ala Phe Tyr Glu Glu Arg Leu Thr Trp His Ser
             180                 185                 190        
 Cys Pro Glu Asp Glu Ala Gln
         195                



      <210> 660
      <211> 393
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(385)
      <223> Xaa = any amino acid or nothing 


      <400> 660
 Ser Arg Pro Ala Arg Gly Ser Leu Arg Arg Ala Met Ala Thr Ser Pro
   1               5                  10                  15    
 Gln Lys Ser Pro Ser Val Pro Lys Ser Pro Thr Pro Lys Ser Pro Pro
              20                  25                  30        
 Ser Arg Lys Lys Asp Asp Ser Phe Leu Gly Lys Leu Gly Gly Thr Leu
          35                  40                  45            
 Ala Arg Arg Lys Lys Ala Lys Glu Val Ser Glu Leu Gln Glu Glu Gly
      50                  55                  60                
 Met Asn Ala Ile Asn Leu Pro Leu Ser Pro Ile Pro Phe Glu Leu Asp
  65                  70                  75                  80
 Pro Glu Asp Thr Met Leu Glu Glu Asn Glu Val Arg Thr Met Val Asp
                  85                  90                  95    
 Pro Asn Ser Arg Ser Asp Pro Lys Leu Gln Glu Leu Met Lys Val Leu
             100                 105                 110        
 Ile Asp Trp Ile Asn Asp Val Leu Val Gly Glu Arg Ile Ile Val Lys
         115                 120                 125            
 Asp Leu Ala Glu Asp Leu Tyr Asp Gly Gln Val Leu Gln Lys Leu Phe
     130                 135                 140                
 Glu Lys Leu Glu Ser Glu Lys Leu Asn Val Ala Glu Val Thr Gln Ser
 145                 150                 155                 160
 Glu Ile Ala Gln Lys Gln Lys Leu Gln Thr Val Leu Glu Lys Ile Asn
                 165                 170                 175    
 Glu Thr Leu Lys Leu Pro Pro Arg Ser Ile Lys Trp Asn Val Asp Ser
             180                 185                 190        
 Val His Ala Lys Ser Leu Val Ala Ile Leu His Leu Leu Val Ala Leu
         195                 200                 205            
 Ser Gln Tyr Phe Arg Ala Pro Ile Arg Leu Pro Asp His Val Ser Ile
     210                 215                 220                
 Gln Val Val Val Val Gln Lys Arg Glu Gly Ile Leu Gln Ser Arg Gln
 225                 230                 235                 240
 Ile Gln Glu Glu Ile Thr Gly Asn Thr Glu Ala Leu Ser Gly Arg His
                 245                 250                 255    
 Glu Arg Asp Ala Phe Asp Thr Leu Phe Asp His Ala Pro Asp Lys Leu
             260                 265                 270        
 Asn Val Val Lys Lys Thr Leu Ile Thr Phe Val Asn Lys His Leu Asn
         275                 280                 285            
 Lys Leu Asn Leu Glu Val Thr Glu Leu Glu Thr Gln Phe Ala Asp Gly
     290                 295                 300                
 Val Tyr Leu Val Leu Leu Met Gly Leu Leu Lys Gly Tyr Phe Val Pro
 305                 310                 315                 320
 Leu Pro Ser Phe Phe Leu Thr Pro Asp Ser Phe Glu Gln Lys Val Leu
                 325                 330                 335    
 Asn Val Ser Phe Ala Phe Glu Ala Leu Met Gln Asp Gly Arg Val Gly
             340                 345                 350        
 Lys Ser Gln Asn Arg Gly Gln Lys Thr Xaa Ser Thr Val Thr Xaa Lys
         355                 360                 365            
 Ser Thr Leu Arg Val Leu Tyr Asn Leu Phe Thr Lys Tyr Arg Asn Val
     370                 375                 380                
 Glu
 385



      <210> 661
      <211> 267
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(263)
      <223> Xaa = any amino acid or nothing 


      <400> 661
 Gly Ala Ser Ser Gly Pro Ala Ser Gly Ala Glu Lys Gly Arg Arg Leu
   1               5                  10                  15    
 Gly Val Gly Arg Lys Gln Asp Pro Ser Ser Ile Asp Phe Ser Ala Asp
              20                  25                  30        
 Pro Val Pro Ser Asn Pro Thr Ser Ala Tyr Phe Lys Thr Lys Ser Asn
          35                  40                  45            
 Glu Arg Arg Leu Lys Glu Leu Glu Ser Arg Leu Gln Gln Val Asp Gly
      50                  55                  60                
 Phe Glu Lys Pro Lys Leu Leu Leu Glu Gln Tyr Pro Thr Arg Pro His
  65                  70                  75                  80
 Ile Ala Ala Cys Met Leu Tyr Thr Ile His Asn Thr Tyr Val Thr Leu
                  85                  90                  95    
 Glu Asn Lys Val Val Ala His Leu Gly Cys Gly Cys Gly Ala Leu Ser
             100                 105                 110        
 Ile Arg Thr Ala Met Leu Arg Ala Gly Val Cys Val Gly Phe Asp Ile
         115                 120                 125            
 Tyr Glu Asp Ala Leu Glu Ile Phe Asn Arg Asn Ala Glu Glu Phe Xaa
     130                 135                 140                
 Val Asn Lys Tyr Cys Asp Met Val Gln Cys Gly Cys Val Pro Tyr Tyr
 145                 150                 155                 160
 Pro Asn Arg Met Ser Lys Ser Phe Asp Thr Val Ile Met Asn Pro Pro
                 165                 170                 175    
 Phe Gly Thr Lys Asn Asn Lys Gly Thr Asp Met Ala Phe Leu Lys Thr
             180                 185                 190        
 Ala Leu Glu Met Ala Arg Thr Ala Val Tyr Ser Leu His Lys Ser Ser
         195                 200                 205            
 Thr Arg Glu His Val Gln Lys Lys Ala Ala Glu Trp Lys Ile Lys Ile
     210                 215                 220                
 Asp Ile Ile Ala Gly Gly Phe Cys Phe Thr Glu Leu Arg Tyr Asp Leu
 225                 230                 235                 240
 Pro Ala Ser Tyr Lys Phe His Lys Lys Lys Ser Val Asp Ile Glu Val
                 245                 250                 255    
 Asp Leu Ile Arg Phe Ser Phe
             260            



      <210> 662
      <211> 472
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(455)
      <223> Xaa = any amino acid or nothing 


      <400> 662
 Pro Arg Pro Glu Ala Ala Val Gly Glu Pro Ala Val Gly Leu Asp Ala
   1               5                  10                  15    
 Gly Ala Thr Asp Met Gly Glu Pro Gln Gly Ser Met Arg Ile Leu Val
              20                  25                  30        
 Thr Gly Gly Ser Gly Leu Val Gly Lys Ala Ile Gln Lys Val Val Ala
          35                  40                  45            
 Asp Gly Ala Gly Leu Pro Gly Glu Asp Trp Val Phe Val Ser Ser Lys
      50                  55                  60                
 Asp Ala Asp Leu Thr Val Ala Gly Leu Ala Trp Val Cys Leu Ala Val
  65                  70                  75                  80
 Phe Leu Glu Lys Gln Thr Pro Ser His Leu Phe Leu Glu Ala Cys Thr
                  85                  90                  95    
 Leu Ile Ser Ala Arg Pro Trp Gly His Pro Pro Phe Xaa Leu Ser Leu
             100                 105                 110        
 Leu Pro Xaa Ser His Pro Asp Pro Ala Leu Gly Thr Gln Pro Trp Trp
         115                 120                 125            
 Cys Trp Phe Pro Pro Glu Pro Pro Asp Ser Leu Ala Phe Tyr Lys Asp
     130                 135                 140                
 Thr Ala Gln Thr Arg Ala Leu Phe Glu Lys Val Gln Pro Thr His Val
 145                 150                 155                 160
 Ile His Leu Ala Ala Met Val Gly Gly Leu Phe Arg Asn Ile Lys Tyr
                 165                 170                 175    
 Asn Leu Asp Phe Trp Arg Lys Asn Val His Met Asn Asp Asn Val Leu
             180                 185                 190        
 His Ser Ala Phe Glu Val Gly Ala Arg Lys Val Leu Val Ser Cys Leu
         195                 200                 205            
 Ser Thr Cys Asn Leu Pro Leu Asp Lys Asp Gly Pro Thr Pro Ile Lys
     210                 215                 220                
 Ile Glu Asp Pro Xaa Phe His Asn Gly Pro Pro His Asn Ser Lys Tyr
 225                 230                 235                 240
 Gly Tyr Ser Tyr Ala Lys Lys Met Ile Asp Val Gln Asn Arg Ala Tyr
                 245                 250                 255    
 Phe Gln Gln Tyr Gly Cys Thr Phe Thr Ala Val Ile Pro Thr Asn Val
             260                 265                 270        
 Phe Gly Pro His Asp Asn Phe Asn Ile Glu Asp Gly His Val Leu Pro
         275                 280                 285            
 Gly Leu Ile His Lys Val His Leu Ala Lys Ser Ser Gly Ser Ala Leu
     290                 295                 300                
 Thr Val Trp Val Pro Gly Asn Pro Arg Ser Gln Phe Ile Tyr Ser Leu
 305                 310                 315                 320
 Asp Leu Ala Gln Leu Phe Ile Trp Val Leu Arg Glu Tyr Asn Glu Val
                 325                 330                 335    
 Glu Pro Ile Phe Leu Ser Val Gly Glu Glu Asp Glu Val Ser Ile Lys
             340                 345                 350        
 Glu Ala Ala Glu Ala Val Val Glu Ala Asn Gly Leu Ser His Gly Glu
         355                 360                 365            
 Val Thr Phe Xaa Tyr Asn Gln Ser Arg Asp Gly Gln Phe Lys Lys Thr
     370                 375                 380                
 Ala Ser Asn Ser Lys Leu Arg Thr Tyr Leu Ala Arg Ile Ser Arg Phe
 385                 390                 395                 400
 Thr Pro Pro Ser Ser Lys Ala Val Lys Glu Thr Cys Ala Trp Phe Thr
                 405                 410                 415    
 Xaa Gln Thr Tyr Glu Gln Ala Arg Lys Leu Lys Leu Glu Asp Arg Ile
             420                 425                 430        
 Arg Cys Gln Arg Thr Ile Gly Leu Ala Glu Ala Gln Arg Ala Thr His
         435                 440                 445            
 Pro Ser Asn Leu Ala Arg Ser
     450                 455



      <210> 663
      <211> 814
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(800)
      <223> Xaa = any amino acid or nothing 


      <400> 663
 Ser Ile Pro Tyr Asn Cys Phe Glu Asn Pro Ala Trp Thr Met Ala Thr
   1               5                  10                  15    
 Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro Asp Arg Lys
              20                  25                  30        
 Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp Ser Gly Ile
          35                  40                  45            
 His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly Lys Gly Asn
      50                  55                  60                
 Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr Glu Trp Glu
  65                  70                  75                  80
 Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala Asp Ile Asp
                  85                  90                  95    
 Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala Ala Met Phe
             100                 105                 110        
 Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr Gln Phe Asp
         115                 120                 125            
 Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro Ser Gln Met
     130                 135                 140                
 Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp Asp Ala Glu
 145                 150                 155                 160
 Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu Asn Asp Glu
                 165                 170                 175    
 Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His Gln Leu Ser
             180                 185                 190        
 Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro Gln Met Val
         195                 200                 205            
 Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val Glu Thr Ala
     210                 215                 220                
 Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His Arg Glu Gly
 225                 230                 235                 240
 Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu Val Lys Met
                 245                 250                 255    
 Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile Thr Thr Leu
             260                 265                 270        
 His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala Val Arg Leu
         275                 280                 285            
 Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys Thr Asn Val
     290                 295                 300                
 Thr Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu Ala Tyr Gly
 305                 310                 315                 320
 Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly Pro Gln Ala
                 325                 330                 335    
 Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu Leu Trp Thr
             340                 345                 350        
 Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser Asn Lys Pro
         355                 360                 365            
 Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu His Leu Thr
     370                 375                 380                
 Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr Leu Arg Asn
 385                 390                 395                 400
 Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly Leu Leu Gly
                 405                 410                 415    
 Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val Val Thr Cys
             420                 425                 430        
 Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr Lys Asn Lys
         435                 440                 445            
 Met Met Val Cys Pro Lys Trp Gly Gly Tyr Lys Arg Leu Leu Arg Ala
     450                 455                 460                
 Xaa Leu Val Leu Arg Ala Gly Gly Gln Gly Lys Thr Ser Leu Glu Pro
 465                 470                 475                 480
 Ala Ile Cys Ala Leu Arg His Leu Asp Thr Ala Arg His Gln Glu Ala
                 485                 490                 495    
 Glu Met Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val
             500                 505                 510        
 Val Lys Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr
         515                 520                 525            
 Val Gly Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro
     530                 535                 540                
 Leu Arg Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg
 545                 550                 555                 560
 Ala His Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln
                 565                 570                 575    
 Gln Phe Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr
             580                 585                 590        
 Gly Ala Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile
         595                 600                 605            
 Arg Gly Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro
     610                 615                 620                
 Ile Glu Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala
 625                 630                 635                 640
 Gln Asp Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala
                 645                 650                 655    
 Pro Leu Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr
             660                 665                 670        
 Ala Ala Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Asn
         675                 680                 685            
 Arg Lys Arg Phe Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu
     690                 695                 700                
 Pro Met Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Trp Cys
 705                 710                 715                 720
 Pro Gly Glu Asn Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg
                 725                 730                 735    
 Ser Phe His Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro
             740                 745                 750        
 Met Met Glu His Glu Ile Gly Gly His His Pro Gly Ala Asp Tyr Pro
         755                 760                 765            
 Val Asp Gly Leu Pro Asp Met Gly His Ala Gln Asp Leu Met Asp Gly
     770                 775                 780                
 Leu Pro Pro Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu
 785                 790                 795                 800





      <210> 664
      <211> 1220
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(1177)
      <223> Xaa = any amino acid or nothing 


      <400> 664
 Met Leu Arg Arg Val Thr Val Ala Ala Val Cys Ala Thr Arg Arg Lys
   1               5                  10                  15    
 Leu Cys Glu Ala Gly Arg Glu Leu Ala Ala Leu Trp Gly Ile Glu Thr
              20                  25                  30        
 Arg Gly Arg Cys Glu Asp Ser Ala Ala Ala Arg Pro Phe Pro Ile Leu
          35                  40                  45            
 Ala Met Pro Gly Arg Asn Lys Ala Lys Ser Thr Cys Ser Cys Pro Asp
      50                  55                  60                
 Leu Gln Pro Asn Gly Gln Asp Leu Gly Glu Asn Ser Arg Val Ala Arg
  65                  70                  75                  80
 Leu Gly Ala Asp Glu Ser Glu Glu Glu Gly Arg Arg Gly Ser Leu Ser
                  85                  90                  95    
 Asn Ala Gly Asp Pro Glu Ile Val Lys Ser Pro Ser Asp Pro Lys Gln
             100                 105                 110        
 Tyr Arg Tyr Ile Lys Leu Gln Asn Gly Leu Gln Ala Leu Leu Ile Ser
         115                 120                 125            
 Asp Leu Ser Asn Met Glu Gly Lys Thr Gly Asn Thr Thr Asp Asp Glu
     130                 135                 140                
 Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Asp Asp Asp Glu Asp Ser
 145                 150                 155                 160
 Gly Ala Glu Ile Glu Asp Asp Asp Glu Glu Gly Phe Asp Asp Glu Asp
                 165                 170                 175    
 Glu Phe Asp Asp Glu His Asp Asp Asp Leu Asp Thr Glu Asp Asn Glu
             180                 185                 190        
 Leu Glu Glu Leu Glu Glu Arg Ala Glu Ala Arg Lys Lys Thr Thr Glu
         195                 200                 205            
 Lys Gln Ser Ala Ala Ala Leu Cys Val Gly Val Gly Ser Phe Ala Asp
     210                 215                 220                
 Pro Asp Asp Leu Pro Gly Leu Ala His Phe Leu Glu His Met Val Phe
 225                 230                 235                 240
 Met Gly Ser Leu Lys Tyr Pro Asp Glu Asn Gly Phe Asp Ala Phe Leu
                 245                 250                 255    
 Lys Lys His Gly Gly Ser Asp Asn Ala Ser Thr Asp Cys Glu Arg Thr
             260                 265                 270        
 Val Phe Gln Phe Asp Val Gln Arg Lys Tyr Phe Lys Glu Ala Leu Asp
         275                 280                 285            
 Arg Trp Ala Gln Phe Phe Ile His Pro Leu Met Ile Arg Asp Ala Ile
     290                 295                 300                
 Asp Arg Glu Val Glu Ala Val Asp Ser Glu Tyr Gln Leu Ala Arg Pro
 305                 310                 315                 320
 Ser Asp Ala Asn Arg Lys Glu Met Leu Phe Gly Ser Leu Ala Arg Pro
                 325                 330                 335    
 Gly His Pro Met Gly Lys Phe Phe Trp Gly Asn Ala Glu Thr Leu Lys
             340                 345                 350        
 His Glu Pro Arg Lys Asn Asn Ile Asp Thr His Ala Arg Leu Arg Glu
         355                 360                 365            
 Phe Trp Met Arg Tyr Tyr Ser Ser His Tyr Met Thr Leu Val Val Gln
     370                 375                 380                
 Ser Lys Glu Thr Leu Asp Thr Leu Glu Lys Trp Val Thr Glu Ile Phe
 385                 390                 395                 400
 Ser Gln Ile Pro Asn Asn Gly Leu Pro Arg Pro Asn Phe Gly His Leu
                 405                 410                 415    
 Thr Asp Pro Phe Asp Thr Pro Ala Phe Asn Lys Leu Tyr Arg Val Val
             420                 425                 430        
 Pro Ile Arg Lys Ile His Ala Leu Thr Ile Thr Trp Gly Thr Ser Phe
         435                 440                 445            
 Leu Asn Gln Gln His Tyr Arg Gly Val Lys Pro Leu His Tyr Ile Ser
     450                 455                 460                
 Trp Arg Val Gly Pro Glu Gly Lys Gly Ser Ile Leu Ser Phe Leu Arg
 465                 470                 475                 480
 Lys Lys Cys Trp Ala Leu Ala Leu Phe Gly Gly Asn Gly Glu Thr Gly
                 485                 490                 495    
 Phe Glu Gln Asn Ser Thr Tyr Ser Val Phe Ser Ile Ser Ile Thr Leu
             500                 505                 510        
 Thr Asp Glu Gly Tyr Glu His Phe Tyr Glu Val Ala Tyr Thr Val Phe
         515                 520                 525            
 Gln Asp Leu Lys Met Leu Gln Lys Leu Gly Pro Glu Lys Arg Ile Phe
     530                 535                 540                
 Glu Glu Ile Arg Lys Ile Glu Asp Asn Glu Phe His Tyr Gln Glu Gln
 545                 550                 555                 560
 Thr Asp Pro Val Glu Tyr Val Glu Asn Met Cys Glu Asn Met Gln Leu
                 565                 570                 575    
 Tyr Pro Leu Gln Asp Ile Leu Thr Gly Asp Gln Leu Leu Phe Glu Tyr
             580                 585                 590        
 Lys Pro Glu Val Ile Gly Glu Ala Leu Asn Gln Leu Val Pro Gln Lys
         595                 600                 605            
 Ala Asn Leu Val Leu Leu Ser Gly Ala Asn Glu Gly Lys Cys Asp Leu
     610                 615                 620                
 Lys Glu Lys Trp Phe Gly Thr Gln Tyr Ser Ile Glu Asp Ile Glu Asn
 625                 630                 635                 640
 Ser Trp Ala Glu Leu Trp Asn Ser Asn Phe Glu Leu Asn Pro Asp Leu
                 645                 650                 655    
 His Leu Pro Ala Glu Asn Lys Tyr Ile Ala Thr Asp Phe Thr Leu Glu
             660                 665                 670        
 Gly Phe Arg Phe Ala Pro Glu Thr Glu Tyr Pro Val Lys Ile Val Asn
         675                 680                 685            
 Thr Pro Gln Gly Cys Leu Trp Tyr Lys Lys Asp Asn Lys Phe Lys Ile
     690                 695                 700                
 Pro Lys Ala Tyr Ile Arg Phe His Leu Ile Ser Pro Leu Ile Gln Lys
 705                 710                 715                 720
 Ser Ala Ala Asn Val Val Leu Phe Asp Ile Phe Val Asn Ile Leu Thr
                 725                 730                 735    
 His Asn Leu Ala Glu Pro Ala Tyr Glu Ala Asp Val Gly Thr Ala Gly
             740                 745                 750        
 Ser Ile Lys Leu Val Ala Gly Glu His Gly Leu Ile Ile Arg Val Lys
         755                 760                 765            
 Gly Phe Asn His Lys Leu Pro Leu Leu Phe Gln Leu Ile Ile Asp Tyr
     770                 775                 780                
 Leu Ala Glu Phe Asn Ser Thr Pro Ala Val Phe Thr Met Ile Thr Glu
 785                 790                 795                 800
 Gln Leu Lys Lys Thr Tyr Phe Asn Ile Leu Ile Lys Pro Glu Thr Leu
                 805                 810                 815    
 Ala Lys Asp Val Arg Leu Leu Ile Leu Glu Tyr Ala Arg Trp Ser Met
             820                 825                 830        
 Ile Asp Lys Tyr Gln Ala Leu Met Asp Gly Leu Ser Leu Glu Ser Leu
         835                 840                 845            
 Leu Ser Phe Val Lys Glu Phe Lys Ser Gln Leu Phe Val Glu Gly Leu
     850                 855                 860                
 Val Gln Gly Asn Val Thr Ser Thr Glu Ser Met Asp Phe Leu Lys Tyr
 865                 870                 875                 880
 Val Val Asp Lys Leu Asn Phe Gln Ala Ser Gly Ser Arg Glu Met Pro
                 885                 890                 895    
 Val Ala Val Ser Arg Val Val Glu Leu Pro Ser Gly Pro Pro Phe Xaa
             900                 905                 910        
 Cys Lys Ser Glu Lys Leu Leu Asn Gln Gly Xaa Ala Asn Phe Glu Val
         915                 920                 925            
 Thr Val Tyr Tyr Gln Ser Gly Thr Arg Ser Leu Arg Glu Tyr Thr Leu
     930                 935                 940                
 Met Glu Leu Leu Val Met His Met Glu Lys Glu Pro Cys Phe Asp Phe
 945                 950                 955                 960
 Leu Arg Thr Lys Gln Thr Leu Gly Tyr Leu Cys Leu Pro Leu Pro Cys
                 965                 970                 975    
 Arg Glu His Ile Gly Gly Ile Leu Gly Phe Ser Leu Arg Trp Gly Asp
             980                 985                 990        
 Arg His Thr Gln Tyr Asn Ser Glu Ser Cys Xaa Ile Arg Lys Ile Glu
         995                1000                1005            
 Glu Phe Leu Ser Ser Phe Glu Gly Lys Ile Glu Asp Pro Leu Leu Lys
    1010                1015                1020                
 Arg Ala Phe Asn His Pro Arg Ser Pro Ala Leu Ile Lys Leu Lys Glu
1025                1030                1035                1040
 Cys Glu Asp Thr Pro Thr Leu Gly Gly Arg Lys Val Asp Arg Lys Leu
                1045                1050                1055    
 Gly Met Lys Val Val Asn Thr Arg Gln Tyr Pro Pro Leu Asn Arg Pro
            1060                1065                1070        
 Cys Pro His Glu Ile Glu Ala Thr Glu Ser His Ser Ser Lys Ser Ser
        1075                1080                1085            
 Thr Leu Val Asn Trp Phe Lys Ala His Arg Gly Pro Arg Lys Xaa Asn
    1090                1095                1100                
 Ala Ser Ala Phe Met Xaa Val Val Gly Tyr Gly Lys Tyr Glu Leu Glu
1105                1110                1115                1120
 Glu Asp Gly Pro Pro Ser Ser Glu Asp Ser Asn Ser Ser Cys Glu Val
                1125                1130                1135    
 Met Gln Leu Thr Tyr Leu Pro Thr Ser Pro Leu Ala Gly Gln Ile Val
            1140                1145                1150        
 Phe Ile Pro Ile Tyr Xaa Cys Ser Gly Leu Phe Thr Thr Thr Leu Asn
        1155                1160                1165            
 Leu Leu Pro Tyr His Lys Ile Val Lys
    1170                1175        



      <210> 665
      <211> 1220
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(1177)
      <223> Xaa = any amino acid or nothing 


      <400> 665
 Met Leu Arg Arg Val Thr Val Ala Ala Val Cys Ala Thr Arg Arg Lys
   1               5                  10                  15    
 Leu Cys Glu Ala Gly Arg Glu Leu Ala Ala Leu Trp Gly Ile Glu Thr
              20                  25                  30        
 Arg Gly Arg Cys Glu Asp Ser Ala Ala Ala Arg Pro Phe Pro Ile Leu
          35                  40                  45            
 Ala Met Pro Gly Arg Asn Lys Ala Lys Ser Thr Cys Ser Cys Pro Asp
      50                  55                  60                
 Leu Gln Pro Asn Gly Gln Asp Leu Gly Glu Asn Ser Arg Val Ala Arg
  65                  70                  75                  80
 Leu Gly Ala Asp Glu Ser Glu Glu Glu Gly Arg Arg Gly Ser Leu Ser
                  85                  90                  95    
 Asn Ala Gly Asp Pro Glu Ile Val Lys Ser Pro Ser Asp Pro Lys Gln
             100                 105                 110        
 Tyr Arg Tyr Ile Lys Leu Gln Asn Gly Leu Gln Ala Leu Leu Ile Ser
         115                 120                 125            
 Asp Leu Ser Asn Met Glu Gly Lys Thr Gly Asn Thr Thr Asp Asp Glu
     130                 135                 140                
 Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Asp Asp Asp Glu Asp Ser
 145                 150                 155                 160
 Gly Ala Glu Ile Glu Asp Asp Asp Glu Glu Gly Phe Asp Asp Glu Asp
                 165                 170                 175    
 Glu Phe Asp Asp Glu His Asp Asp Asp Leu Asp Thr Glu Asp Asn Glu
             180                 185                 190        
 Leu Glu Glu Leu Glu Glu Arg Ala Glu Ala Arg Lys Lys Thr Thr Glu
         195                 200                 205            
 Lys Gln Ser Ala Ala Ala Leu Cys Val Gly Val Gly Ser Phe Ala Asp
     210                 215                 220                
 Pro Asp Asp Leu Pro Gly Leu Ala His Phe Leu Glu His Met Val Phe
 225                 230                 235                 240
 Met Gly Ser Leu Lys Tyr Pro Asp Glu Asn Gly Phe Asp Ala Phe Leu
                 245                 250                 255    
 Lys Lys His Gly Gly Ser Asp Asn Ala Ser Thr Asp Cys Glu Arg Thr
             260                 265                 270        
 Val Phe Gln Phe Asp Val Gln Arg Lys Tyr Phe Lys Glu Ala Leu Asp
         275                 280                 285            
 Arg Trp Ala Gln Phe Phe Ile His Pro Leu Met Ile Arg Asp Ala Ile
     290                 295                 300                
 Asp Arg Glu Val Glu Ala Val Asp Ser Glu Tyr Gln Leu Ala Arg Pro
 305                 310                 315                 320
 Ser Asp Ala Asn Arg Lys Glu Met Leu Phe Gly Ser Leu Ala Arg Pro
                 325                 330                 335    
 Gly His Pro Met Gly Lys Phe Phe Trp Gly Asn Ala Glu Thr Leu Lys
             340                 345                 350        
 His Glu Pro Arg Lys Asn Asn Ile Asp Thr His Ala Arg Leu Arg Glu
         355                 360                 365            
 Phe Trp Met Arg Tyr Tyr Ser Ser His Tyr Met Thr Leu Val Val Gln
     370                 375                 380                
 Ser Lys Glu Thr Leu Asp Thr Leu Glu Lys Trp Val Thr Glu Ile Phe
 385                 390                 395                 400
 Ser Gln Ile Pro Asn Asn Gly Leu Pro Arg Pro Asn Phe Gly His Leu
                 405                 410                 415    
 Thr Asp Pro Phe Asp Thr Pro Ala Phe Asn Lys Leu Tyr Arg Val Val
             420                 425                 430        
 Pro Ile Arg Lys Ile His Ala Leu Thr Ile Thr Trp Gly Thr Ser Phe
         435                 440                 445            
 Leu Asn Gln Gln His Tyr Arg Gly Val Lys Pro Leu His Tyr Ile Ser
     450                 455                 460                
 Trp Arg Val Gly Pro Glu Gly Lys Gly Ser Ile Leu Ser Phe Leu Arg
 465                 470                 475                 480
 Lys Lys Cys Trp Ala Leu Ala Leu Phe Gly Gly Asn Gly Glu Thr Gly
                 485                 490                 495    
 Phe Glu Gln Asn Ser Thr Tyr Ser Val Phe Ser Ile Ser Ile Thr Leu
             500                 505                 510        
 Thr Asp Glu Gly Tyr Glu His Phe Tyr Glu Val Ala Tyr Thr Val Phe
         515                 520                 525            
 Gln Asp Leu Lys Met Leu Gln Lys Leu Gly Pro Glu Lys Arg Ile Phe
     530                 535                 540                
 Glu Glu Ile Arg Lys Ile Glu Asp Asn Glu Phe His Tyr Gln Glu Gln
 545                 550                 555                 560
 Thr Asp Pro Val Glu Tyr Val Glu Asn Met Cys Glu Asn Met Gln Leu
                 565                 570                 575    
 Tyr Pro Leu Gln Asp Ile Leu Thr Gly Asp Gln Leu Leu Phe Glu Tyr
             580                 585                 590        
 Lys Pro Glu Val Ile Gly Glu Ala Leu Asn Gln Leu Val Pro Gln Lys
         595                 600                 605            
 Ala Asn Leu Val Leu Leu Ser Gly Ala Asn Glu Gly Lys Cys Asp Leu
     610                 615                 620                
 Lys Glu Lys Trp Phe Gly Thr Gln Tyr Ser Ile Glu Asp Ile Glu Asn
 625                 630                 635                 640
 Ser Trp Ala Glu Leu Trp Asn Ser Asn Phe Glu Leu Asn Pro Asp Leu
                 645                 650                 655    
 His Leu Pro Ala Glu Asn Lys Tyr Ile Ala Thr Asp Phe Thr Leu Glu
             660                 665                 670        
 Gly Phe Arg Phe Ala Pro Glu Thr Glu Tyr Pro Val Lys Ile Val Asn
         675                 680                 685            
 Thr Pro Gln Gly Cys Leu Trp Tyr Lys Lys Asp Asn Lys Phe Lys Ile
     690                 695                 700                
 Pro Lys Ala Tyr Ile Arg Phe His Leu Ile Ser Pro Leu Ile Gln Lys
 705                 710                 715                 720
 Ser Ala Ala Asn Val Val Leu Phe Asp Ile Phe Val Asn Ile Leu Thr
                 725                 730                 735    
 His Asn Leu Ala Glu Pro Ala Tyr Glu Ala Asp Val Gly Thr Ala Gly
             740                 745                 750        
 Ser Ile Lys Leu Val Ala Gly Glu His Gly Leu Ile Ile Arg Val Lys
         755                 760                 765            
 Gly Phe Asn His Lys Leu Pro Leu Leu Phe Gln Leu Ile Ile Asp Tyr
     770                 775                 780                
 Leu Ala Glu Phe Asn Ser Thr Pro Ala Val Phe Thr Met Ile Thr Glu
 785                 790                 795                 800
 Gln Leu Lys Lys Thr Tyr Phe Asn Ile Leu Ile Lys Pro Glu Thr Leu
                 805                 810                 815    
 Ala Lys Asp Val Arg Leu Leu Ile Leu Glu Tyr Ala Arg Trp Ser Met
             820                 825                 830        
 Ile Asp Lys Tyr Gln Ala Leu Met Asp Gly Leu Ser Leu Glu Ser Leu
         835                 840                 845            
 Leu Ser Phe Val Lys Glu Phe Lys Ser Gln Leu Phe Val Glu Gly Leu
     850                 855                 860                
 Val Gln Gly Asn Val Thr Ser Thr Glu Ser Met Asp Phe Leu Lys Tyr
 865                 870                 875                 880
 Val Val Asp Lys Leu Asn Phe Gln Ala Ser Gly Ser Arg Glu Met Pro
                 885                 890                 895    
 Val Ala Val Ser Arg Val Val Glu Leu Pro Ser Gly Pro Pro Phe Xaa
             900                 905                 910        
 Cys Lys Ser Glu Lys Leu Leu Asn Gln Gly Xaa Ala Asn Phe Glu Val
         915                 920                 925            
 Thr Val Tyr Tyr Gln Ser Gly Thr Arg Ser Leu Arg Glu Tyr Thr Leu
     930                 935                 940                
 Met Glu Leu Leu Val Met His Met Glu Lys Glu Pro Cys Phe Asp Phe
 945                 950                 955                 960
 Leu Arg Thr Lys Gln Thr Leu Gly Tyr Leu Cys Leu Pro Leu Pro Cys
                 965                 970                 975    
 Arg Glu His Ile Gly Gly Ile Leu Gly Phe Ser Leu Arg Trp Gly Asp
             980                 985                 990        
 Arg His Thr Gln Tyr Asn Ser Glu Ser Cys Xaa Ile Arg Lys Ile Glu
         995                1000                1005            
 Glu Phe Leu Ser Ser Phe Glu Gly Lys Ile Glu Asp Pro Leu Leu Lys
    1010                1015                1020                
 Arg Ala Phe Asn His Pro Arg Ser Pro Ala Leu Ile Lys Leu Lys Glu
1025                1030                1035                1040
 Cys Glu Asp Thr Pro Thr Leu Gly Gly Arg Lys Val Asp Arg Lys Leu
                1045                1050                1055    
 Gly Met Lys Val Val Asn Thr Arg Gln Tyr Pro Pro Leu Asn Arg Pro
            1060                1065                1070        
 Cys Pro His Glu Ile Glu Ala Thr Glu Ser His Ser Ser Lys Ser Ser
        1075                1080                1085            
 Thr Leu Val Asn Trp Phe Lys Ala His Arg Gly Pro Arg Lys Xaa Asn
    1090                1095                1100                
 Ala Ser Ala Phe Met Xaa Val Val Gly Tyr Gly Lys Tyr Glu Leu Glu
1105                1110                1115                1120
 Glu Asp Gly Pro Pro Ser Ser Glu Asp Ser Asn Ser Ser Cys Glu Val
                1125                1130                1135    
 Met Gln Leu Thr Tyr Leu Pro Thr Ser Pro Leu Ala Gly Gln Ile Val
            1140                1145                1150        
 Phe Ile Pro Ile Tyr Xaa Cys Ser Gly Leu Phe Thr Thr Thr Leu Asn
        1155                1160                1165            
 Leu Leu Pro Tyr His Lys Ile Val Lys
    1170                1175        



      <210> 666
      <211> 196
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(183)
      <223> Xaa = any amino acid or nothing 


      <400> 666
 Ala Lys Met Ser Ser Lys Arg Phe Lys Ala Lys Ser Thr Lys Lys Arg
   1               5                  10                  15    
 Pro Ser Cys Val Ser Thr Ser Asn Val Phe Ala Met Phe Tyr Gln Ser
              20                  25                  30        
 His Ile Gln Glu Phe Lys Glu Ala Phe Asn Met Ile Gly Gln Asn Arg
          35                  40                  45            
 Asp Gly Ile Ile Ser Lys Lys Asp Leu His Asp Met Leu Ala Ser Leu
      50                  55                  60                
 Gly Lys Asn Pro Thr Asp Glu Tyr Leu Glu Gly Met Ile Glu Arg Gly
  65                  70                  75                  80
 Pro Val Gly Pro Phe Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu
                  85                  90                  95    
 Lys Leu Asn Gly Thr Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Cys
             100                 105                 110        
 Leu Ala Phe Asp Gly Gly Lys Pro Ser Gly Phe His Pro Leu Arg Asp
         115                 120                 125            
 His Leu Pro Gly Ser Leu Leu His His His Gly Xaa Thr Val Phe Thr
     130                 135                 140                
 Asp Glu Glu Val Asp Glu Met Tyr Arg Glu Gly Thr His Trp Ile Lys
 145                 150                 155                 160
 Glu Arg Ala Thr Phe Asn Tyr Val Glu Phe Thr Arg Ile Leu Lys His
                 165                 170                 175    
 Gly Ala Lys Asp Lys Asp Asp
             180            



      <210> 667
      <211> 251
      <212> PRT
      <213> Homo sapiens


      <400> 667
 Trp His Pro Gly Trp Pro Cys Cys Pro Leu Pro Val Ala Phe Leu Ser
   1               5                  10                  15    
 Arg Trp Leu Gln Ser Phe Val Asp Gly Leu Phe Cys Thr Gly Gly Leu
              20                  25                  30        
 Leu Arg Pro Gly Thr Cys Lys Phe Ala Gly Ala Ala Ser Gln Ala Pro
          35                  40                  45            
 His Ala Pro Ala Phe Leu Arg Ala Arg Gly Glu Pro Gln Asp Pro Leu
      50                  55                  60                
 Ser His Pro Arg Val Pro Ala Gly Gln Cys Gln Thr Ala Arg Met Trp
  65                  70                  75                  80
 Lys His Leu Pro Val His Ser Ser Pro Thr Pro Arg Leu Thr Pro Leu
                  85                  90                  95    
 Leu Glu Asn Cys Arg Pro Arg Trp Leu Leu Pro Gln Leu Val Tyr Leu
             100                 105                 110        
 Gln Gly Trp Gly Ser Leu Leu Pro Ser Leu Arg Pro Ala Ala Leu Asn
         115                 120                 125            
 Ile Gly Trp Ser Leu Leu Ala Arg Glu Phe Leu Tyr Pro Ala Lys Met
     130                 135                 140                
 Ser Val Ser Glu Val Cys Ser Ser Gly Leu Ser Ser Pro Leu Leu Glu
 145                 150                 155                 160
 Gln His Lys Thr Asn Leu Ile Phe Leu Arg Pro Leu Gly Asp Ile Cys
                 165                 170                 175    
 Ser Ala Asn Gly Lys Phe Gly Phe Asn Gln Pro Leu Pro Phe Leu Lys
             180                 185                 190        
 Thr Phe Cys Ser Thr His Arg Ile Leu Ser Cys Thr Tyr Leu Cys Glu
         195                 200                 205            
 Leu Ser Gln Thr Leu Lys Pro Cys Gln Ser Gly Leu Leu Leu Ile Ala
     210                 215                 220                
 Asn Arg Lys Thr Asn Ser Asn Leu Leu Lys Gln Lys Ile Asn Leu Leu
 225                 230                 235                 240
 Ile
    



      <210> 668
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 668
 Glu Ser Trp Phe Gln Thr Ser Glu Gly His Gly Gln Gln Thr Val Val
   1               5                  10                  15    
 Ser Pro Phe Leu Ala Leu Leu Thr Leu Glu Pro Thr Phe Arg His Leu
              20                  25                  30        
 Leu Arg Ile Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys
          35                  40                  45            
 Thr Met Ala Leu Cys Asn Gln Val Leu Ser Ala Ser Leu Ala Ala Asp
      50                  55                  60                
 Thr Pro Thr Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln
  65                  70                  75                  80
 Asn Phe Ile Ala Asp Tyr Phe Glu Thr Glu Ala Gly Gln Cys Phe Gln
                  85                  90                  95    
 Gly Pro Gly Val Ile Phe Leu Thr Lys Arg Ser Arg Gln Val Leu Cys
             100                 105                 110        
 Ser Asp Pro Ser Glu Glu Trp Gly Pro Arg Tyr Ile Ser Ala Thr Trp
         115                 120                 125            
 Glu Leu Ser Ala
     130        



      <210> 669
      <211> 140
      <212> PRT
      <213> Homo sapiens


      <400> 669
 Ala Arg Gly Pro Lys Gly Val Ile Met Arg Val Thr Gly Thr Ala Val
   1               5                  10                  15    
 Gly Met Thr Val Thr Arg Lys Asp Lys Gly Ala Leu Leu Leu Val Ala
              20                  25                  30        
 Thr His Gln Phe Asp Lys Glu Cys Cys Glu Ile Phe Ile Tyr Leu Phe
          35                  40                  45            
 Ile Tyr Phe Glu Met Glu Phe His Ser Cys Leu Pro Arg Leu Glu Cys
      50                  55                  60                
 Gly Gly Thr Ile Ser Ala His Cys Asn Leu His Leu Pro Gly Ser Ser
  65                  70                  75                  80
 Asp Ser Pro Ala Ser Ala Ser Gln Val Pro Gly Thr Thr Gly Ala Cys
                  85                  90                  95    
 His His Thr Gln Leu Asn Phe Val Phe Leu Val Glu Met Gly Phe His
             100                 105                 110        
 His Val Gly Gln Asp Gly Leu Glu Pro Leu Asn Leu Met Ile Cys Leu
         115                 120                 125            
 Pro Arg Pro Pro Lys Val Leu Gly Leu Gln Ala
     130                 135                



      <210> 670
      <211> 543
      <212> PRT
      <213> Homo sapiens


      <400> 670
 Ala Lys Arg Asn Arg Cys Leu Glu Val Ile Met Ile Ser Pro Asp Pro
   1               5                  10                  15    
 Arg Pro Ser Pro Gly Leu Ala Arg Gly Ala Glu Ser Tyr Glu Ala Lys
              20                  25                  30        
 Cys Glu Arg Arg Gln Glu Ile Arg Glu Ser Arg Arg Cys Arg Pro Asn
          35                  40                  45            
 Val Thr Thr Cys Arg Gln Val Gly Lys Thr Leu Arg Ile Gln Gln Arg
      50                  55                  60                
 Glu Gln Leu Gln Arg Ala Arg Leu Gln Gln Phe Phe Arg Arg Arg Asn
  65                  70                  75                  80
 Leu Glu Leu Glu Glu Lys Gly Lys Ala Gln His Pro Gln Ala Arg Glu
                  85                  90                  95    
 Gln Gly Pro Ser Arg Arg Pro Gly Gln Val Thr Gly Thr Ser Ser Glu
             100                 105                 110        
 Val Phe Pro Ala Gln His Pro Pro Pro Ser Gly Ile Cys Arg Asp Leu
         115                 120                 125            
 Ser Asp His Leu Ser Ser Gln Ala Gly Gly Leu Pro Pro Gln Asp Thr
     130                 135                 140                
 Pro Ile Lys Lys Pro Pro Lys His His Arg Gly Thr Gln Thr Lys Ala
 145                 150                 155                 160
 Glu Gly Pro Thr Ile Lys Asn Asp Ala Ser Gln Gln Thr Asn Tyr Gly
                 165                 170                 175    
 Val Ala Val Leu Asp Lys Glu Ile Ile Gln Leu Ser Asp Tyr Leu Lys
             180                 185                 190        
 Glu Ala Leu Gln Arg Glu Leu Val Leu Lys Gln Lys Met Val Ile Leu
         195                 200                 205            
 Gln Asp Leu Leu Ser Thr Leu Ile Gln Ala Ser Asp Ser Ser Trp Lys
     210                 215                 220                
 Gly Gln Leu Asn Glu Asp Lys Leu Lys Gly Lys Leu Arg Ser Leu Glu
 225                 230                 235                 240
 Asn Gln Leu Tyr Thr Cys Thr Gln Lys Tyr Ser Pro Trp Gly Met Lys
                 245                 250                 255    
 Lys Val Leu Leu Glu Met Glu Asp Gln Lys Asn Ser Tyr Glu Gln Lys
             260                 265                 270        
 Ala Lys Glu Ser Leu Gln Lys Val Leu Glu Glu Lys Met Asn Ala Glu
         275                 280                 285            
 Gln Gln Leu Gln Ser Thr Gln Arg Ser Leu Ala Leu Ala Glu Gln Lys
     290                 295                 300                
 Cys Glu Glu Trp Arg Ser Gln Tyr Glu Ala Leu Lys Glu Asp Trp Arg
 305                 310                 315                 320
 Thr Leu Gly Thr Gln His Arg Glu Leu Glu Ser Gln Leu His Val Leu
                 325                 330                 335    
 Gln Ser Lys Leu Gln Gly Ala Asp Ser Arg Asp Leu Gln Met Asn Gln
             340                 345                 350        
 Ala Leu Arg Phe Leu Glu Asn Glu His Gln Gln Leu Gln Ala Lys Ile
         355                 360                 365            
 Glu Cys Leu Gln Gly Asp Arg Asp Leu Cys Ser Leu Asp Thr Gln Asp
     370                 375                 380                
 Leu Gln Asp Gln Leu Lys Arg Ser Glu Ala Glu Lys Leu Thr Leu Val
 385                 390                 395                 400
 Thr Arg Val Gln Gln Leu Gln Gly Leu Leu Gln Asn Gln Ser Leu Gln
                 405                 410                 415    
 Leu Gln Glu Gln Glu Lys Leu Leu Thr Lys Lys Asp Gln Ala Leu Pro
             420                 425                 430        
 Val Trp Ser Pro Lys Ser Phe Pro Asn Glu Val Glu Pro Glu Gly Thr
         435                 440                 445            
 Gly Lys Glu Lys Asp Trp Asp Leu Arg Asp Gln Leu Gln Lys Lys Thr
     450                 455                 460                
 Leu Gln Leu Gln Ala Lys Glu Lys Glu Cys Arg Glu Leu His Ser Glu
 465                 470                 475                 480
 Leu Asp Asn Leu Ser Asp Glu Tyr Leu Ser Cys Leu Arg Lys Leu Gln
                 485                 490                 495    
 His Cys Arg Glu Glu Leu Asn Gln Ser Gln Gln Leu Pro Pro Arg Arg
             500                 505                 510        
 Gln Cys Gly Lys Gly Leu Pro Val Leu Met Val Val Ile Ala Pro Ala
         515                 520                 525            
 Leu Ala Val Phe Leu Ala Asn Lys Asn Asn Leu Met Ile
     530                 535                 540    



      <210> 671
      <211> 381
      <212> PRT
      <213> Homo sapiens


      <400> 671
 Ala Val Ser Ala Pro Gly Leu Thr Phe Lys Met Val His Ala Glu Ala
   1               5                  10                  15    
 Phe Ser Arg Pro Leu Ser Arg Asn Glu Val Val Gly Leu Ile Phe Arg
              20                  25                  30        
 Leu Thr Ile Phe Gly Ala Val Thr Tyr Phe Thr Ile Lys Trp Met Val
          35                  40                  45            
 Asp Ala Ile Asp Pro Thr Arg Lys Gln Lys Val Glu Ala Gln Lys Gln
      50                  55                  60                
 Ala Glu Lys Leu Met Lys Gln Ile Gly Val Lys Asn Val Lys Leu Ser
  65                  70                  75                  80
 Glu Tyr Glu Met Ser Ile Ala Ala His Leu Val Asp Pro Leu Asn Met
                  85                  90                  95    
 His Val Thr Trp Ser Asp Ile Ser Arg Phe Ser Gly Asp Val Ile Thr
             100                 105                 110        
 Asp Leu Lys Asp Thr Val Ile Leu Pro Ile Lys Lys Lys His Leu Phe
         115                 120                 125            
 Glu Asn Ser Arg Leu Leu Gln Pro Pro Lys Gly Val Leu Leu Tyr Gly
     130                 135                 140                
 Pro Pro Gly Cys Gly Lys Thr Leu Ile Ala Lys Ala Thr Ala Lys Glu
 145                 150                 155                 160
 Ala Gly Cys Arg Phe Ile Asn Leu Gln Pro Ser Thr Leu Thr Asp Lys
                 165                 170                 175    
 Trp Tyr Gly Glu Ser Gln Lys Leu Ala Ala Ala Val Phe Ser Leu Ala
             180                 185                 190        
 Ile Lys Leu Gln Pro Ser Ile Ile Leu Ile Asp Glu Ile Asp Ser Phe
         195                 200                 205            
 Leu Arg Thr Gly Gln Gly Ser Asp His Glu Ala Thr Ala Met Met Lys
     210                 215                 220                
 Ala Gln Phe Met Ser Leu Trp Asp Gly Leu Asp Thr Asp His Ser Cys
 225                 230                 235                 240
 Gln Val Ile Val Met Gly Ala Thr Asn Arg Pro Gln Asp Leu Asp Ser
                 245                 250                 255    
 Ala Ile Met Arg Arg Met Pro Thr Arg Phe His Ile Asn Gln Pro Ala
             260                 265                 270        
 Leu Lys Gln Arg Arg Glu Ala Ile Leu Lys Leu Ile Leu Lys Asn Glu
         275                 280                 285            
 Asn Val Asp Arg His Val Asp Leu His Glu Val Ala Gln Glu Thr Glu
     290                 295                 300                
 Gly Phe Ser Gly Ser Asp Leu Lys Glu Met Cys Arg Asp Ala Ala Leu
 305                 310                 315                 320
 Leu Cys Val Arg Glu Tyr Val Asn Ser Thr Ser Glu Glu Ser His Asp
                 325                 330                 335    
 Glu Asp Glu Ile Arg Pro Val Gln Gln Gln Asp Leu His Arg Ala Ile
             340                 345                 350        
 Glu Lys Met Lys Lys Ser Lys Asp Ala Ala Phe Gln Asn Val Leu Thr
         355                 360                 365            
 His Val Cys Leu Asp
     370            



      <210> 672
      <211> 344
      <212> PRT
      <213> Homo sapiens


      <400> 672
 Thr Gly Asp Ala Pro Pro Ala Cys Leu Ala Glu Leu Gln Gly Ala His
   1               5                  10                  15    
 Pro Gln Ser Ala Thr Ser Arg Ala Pro Pro Gly Ala Arg Met Glu Arg
              20                  25                  30        
 Leu Thr Leu Thr Arg Thr Ile Gly Gly Pro Leu Leu Thr Ala Thr Leu
          35                  40                  45            
 Leu Gly Lys Thr Thr Ile Asn Asp Tyr Gln Val Ile Arg Met Pro Phe
      50                  55                  60                
 Cys His Leu Ser Thr Tyr Ser Leu Val Trp Val Met Ala Ala Val Val
  65                  70                  75                  80
 Leu Cys Thr Ala Gln Val Gln Val Val Thr Gln Asp Glu Arg Glu Gln
                  85                  90                  95    
 Leu Tyr Thr Pro Ala Ser Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu
             100                 105                 110        
 Ala Leu Ile Val Thr Trp Gln Lys Lys Lys Ala Val Ser Pro Glu Asn
         115                 120                 125            
 Met Val Thr Phe Ser Glu Asn His Gly Val Val Ile Gln Pro Ala Tyr
     130                 135                 140                
 Lys Asp Lys Ile Asn Ile Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile
 145                 150                 155                 160
 Thr Phe Trp Asn Ile Thr Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu
                 165                 170                 175    
 Phe Ser Asn Thr Phe Gly Phe Gly Glu Asp Leu Gln Gly Thr Ala Cys
             180                 185                 190        
 Ala Phe Thr Val Tyr Val Gln Pro Ile Val Ser Leu His Tyr Lys Phe
         195                 200                 205            
 Ser Glu Asp His Leu Asn Ile Thr Cys Ser Ala Thr Ala Arg Pro Ala
     210                 215                 220                
 Pro Met Val Phe Trp Lys Val Pro Arg Ser Gly Ile Glu Asn Ser Thr
 225                 230                 235                 240
 Val Thr Leu Ser His Pro Asn Gly Thr Thr Ser Val Thr Ser Ile Leu
                 245                 250                 255    
 His Ile Lys Asp Pro Lys Asn His Val Ala Lys Glu Glu Ile Cys Gln
             260                 265                 270        
 Val Leu His Leu Gly Thr Val Thr Asp Phe Lys Gln Thr Val Asn Lys
         275                 280                 285            
 Gly Tyr Trp Phe Ser Val Pro Leu Leu Leu Ser Ile Val Ser Arg Val
     290                 295                 300                
 Ile Leu Leu Val Leu Ile Ser Ile Leu Leu Tyr Trp Lys Arg His Arg
 305                 310                 315                 320
 Glu Ser Gly Thr Glu Glu Pro Leu Asn
                 325                



      <210> 673
      <211> 351
      <212> PRT
      <213> Homo sapiens


      <400> 673
 Gly Arg Arg Leu Arg Gly Arg Gly Gly Gly Val Glu Gly Gln Pro Glu
   1               5                  10                  15    
 Thr Gly Pro Ala Pro Leu Pro Arg Leu Asp Gly Pro Ser Phe Ala Gly
              20                  25                  30        
 Ile Met Ala Leu Leu Val Asp Arg Val Arg Gly His Trp Arg Ile Ala
          35                  40                  45            
 Ala Gly Leu Leu Phe Asn Leu Leu Val Ser Ile Cys Ile Val Phe Leu
      50                  55                  60                
 Asn Lys Trp Ile Tyr Val Tyr His Gly Phe Pro Asn Met Ser Leu Thr
  65                  70                  75                  80
 Leu Val His Phe Val Val His Leu Gly Leu Gly Leu Tyr Ile Trp Pro
                  85                  90                  95    
 Glu Ala Gly Thr Ser Leu Pro Pro Lys Val Cys Arg Pro Arg Arg Leu
             100                 105                 110        
 Leu Leu Leu Ala Leu Ser Phe Cys Gly Phe Val Ala Phe Thr Asn Leu
         115                 120                 125            
 Ser Leu Gln Asn Asn Thr Ile Gly Thr Tyr Gln Leu Ala Lys Ala Met
     130                 135                 140                
 Thr Thr Pro Val Ile Ile Ala Ile Gln Thr Phe Cys Tyr Gln Lys Thr
 145                 150                 155                 160
 Phe Ser Thr Arg Ile Gln Leu Thr Leu Ile Pro Ile Thr Leu Gly Val
                 165                 170                 175    
 Ile Leu Asn Ser Tyr Tyr Asp Val Lys Phe Asn Phe Leu Gly Met Val
             180                 185                 190        
 Phe Ala Ala Leu Gly Val Leu Val Thr Ser Leu Tyr Gln Val Trp Val
         195                 200                 205            
 Gly Ala Lys Gln His Glu Leu Gln Val Asn Ser Met Gln Leu Leu Tyr
     210                 215                 220                
 Tyr Gln Ala Pro Met Ser Ser Ala Met Leu Leu Val Ala Val Pro Phe
 225                 230                 235                 240
 Phe Glu Pro Val Phe Gly Glu Gly Gly Ile Phe Gly Pro Trp Ser Val
                 245                 250                 255    
 Ser Ala Leu Leu Met Val Leu Leu Ser Gly Val Ile Ala Phe Met Val
             260                 265                 270        
 Asn Leu Ser Ile Tyr Trp Ile Ile Gly Asn Thr Ser Pro Val Thr Tyr
         275                 280                 285            
 Asn Met Phe Gly His Phe Lys Phe Cys Ile Thr Leu Phe Gly Gly Tyr
     290                 295                 300                
 Val Leu Phe Lys Asp Pro Leu Ser Ile Asn Gln Ala Leu Gly Ile Leu
 305                 310                 315                 320
 Cys Thr Leu Phe Gly Ile Leu Ala Tyr Thr His Phe Lys Leu Ser Glu
                 325                 330                 335    
 Gln Glu Gly Ser Arg Ser Lys Leu Ala Gln Arg Pro
             340                 345            



      <210> 674
      <211> 103
      <212> PRT
      <213> Homo sapiens


      <400> 674
 Tyr Tyr Tyr Phe Ser Ala Glu Ser Gly Ser His Ser Val Ala Gln Ala
   1               5                  10                  15    
 Gly Met Gln Trp His Asp His Ser Ser Leu Arg Pro Pro Thr Pro Gly
              20                  25                  30        
 Ser Ser Asp Ser Pro Ala Pro Ala Ser Arg Val Ala Gly Thr Thr Gly
          35                  40                  45            
 Leu Arg His His Ala Arg Leu Ile Gly His Phe Arg Trp Lys Gln Met
      50                  55                  60                
 Thr Gly Ser Leu Thr Pro Thr Phe Leu Ser Ser Leu Pro Val Met Leu
  65                  70                  75                  80
 Leu Leu Lys Ala Gly Arg Glu Thr Pro Trp Ile Lys Ser Arg Ala Arg
                  85                  90                  95    
 Ala Ser Lys Trp Ser Leu
             100        



      <210> 675
      <211> 314
      <212> PRT
      <213> Homo sapiens


      <400> 675
 Pro Cys Arg Gly Ala Glu Met Trp Glu Leu Leu Ala Ala Ala Trp Ala
   1               5                  10                  15    
 Val Gln Gly Leu Gly Gly Trp Gly Ala Asn Ser Tyr Gly Gln Leu Gly
              20                  25                  30        
 Leu Gly His Lys Glu Asp Val Leu Leu Pro Gln Gln Leu Asn Asp Phe
          35                  40                  45            
 Cys Lys Pro Arg Ser Val Arg Arg Ile Thr Gly Gly Gly Gly His Ser
      50                  55                  60                
 Ala Val Val Thr Asp Gly Gly Asp Leu Phe Val Cys Gly Leu Asn Lys
  65                  70                  75                  80
 Asp Gly Gln Leu Gly Leu Gly His Thr Glu Asp Ile Pro Tyr Phe Thr
                  85                  90                  95    
 Pro Ser Lys Ser Leu Phe Gly Cys Pro Ile Gln Gln Val Ala Cys Gly
             100                 105                 110        
 Trp Asp Phe Thr Ile Met Leu Thr Glu Asn Gly Gln Val Leu Ser Cys
         115                 120                 125            
 Gly Ser Asn Ser Phe Gly Gln Leu Gly Val Pro His Gly Pro Arg Arg
     130                 135                 140                
 Cys Val Val Pro Gln Ala Ile Glu Leu His Lys Glu Lys Val Val Cys
 145                 150                 155                 160
 Ile Ala Ala Gly Leu Arg His Ala Val Ala Ala Thr Ala Ser Gly Ile
                 165                 170                 175    
 Val Phe Gln Trp Gly Thr Gly Leu Ala Ser Cys Gly Arg Arg Leu Cys
             180                 185                 190        
 Pro Gly Gln Thr Leu Pro Leu Phe Phe Thr Ala Lys Glu Pro Ser Arg
         195                 200                 205            
 Val Thr Gly Leu Glu Asn Ser Lys Ala Met Cys Val Leu Ala Gly Ser
     210                 215                 220                
 Asp His Ser Ala Ser Leu Thr Asp Ala Gly Glu Val Tyr Val Trp Gly
 225                 230                 235                 240
 Ser Asn Lys His Gly Gln Leu Ala Asn Glu Ala Ala Phe Leu Pro Val
                 245                 250                 255    
 Pro Gln Lys Ile Glu Ala His Cys Phe Gln Asn Glu Lys Val Thr Ala
             260                 265                 270        
 Ile Trp Ser Gly Trp Thr His Leu Val Ala Gln Thr Gly Leu Leu Trp
         275                 280                 285            
 Leu Arg Ser Ile Ile Leu Ala Ile Ile Gly Gly Val Cys Tyr Ser Trp
     290                 295                 300                
 Gly Cys Glu
 305        



      <210> 676
      <211> 314
      <212> PRT
      <213> Homo sapiens


      <400> 676
 Pro Cys Arg Gly Ala Glu Met Trp Glu Leu Leu Ala Ala Ala Trp Ala
   1               5                  10                  15    
 Val Gln Gly Leu Gly Gly Trp Gly Ala Asn Ser Tyr Gly Gln Leu Gly
              20                  25                  30        
 Leu Gly His Lys Glu Asp Val Leu Leu Pro Gln Gln Leu Asn Asp Phe
          35                  40                  45            
 Cys Lys Pro Arg Ser Val Arg Arg Ile Thr Gly Gly Gly Gly His Ser
      50                  55                  60                
 Ala Val Val Thr Asp Gly Gly Asp Leu Phe Val Cys Gly Leu Asn Lys
  65                  70                  75                  80
 Asp Gly Gln Leu Gly Leu Gly His Thr Glu Asp Ile Pro Tyr Phe Thr
                  85                  90                  95    
 Pro Ser Lys Ser Leu Phe Gly Cys Pro Ile Gln Gln Val Ala Cys Gly
             100                 105                 110        
 Trp Asp Phe Thr Ile Met Leu Thr Glu Asn Gly Gln Val Leu Ser Cys
         115                 120                 125            
 Gly Ser Asn Ser Phe Gly Gln Leu Gly Val Pro His Gly Pro Arg Arg
     130                 135                 140                
 Cys Val Val Pro Gln Ala Ile Glu Leu His Lys Glu Lys Val Val Cys
 145                 150                 155                 160
 Ile Ala Ala Gly Leu Arg His Ala Val Ala Ala Thr Ala Ser Gly Ile
                 165                 170                 175    
 Val Phe Gln Trp Gly Thr Gly Leu Ala Ser Cys Gly Arg Arg Leu Cys
             180                 185                 190        
 Pro Gly Gln Thr Leu Pro Leu Phe Phe Thr Ala Lys Glu Pro Ser Arg
         195                 200                 205            
 Val Thr Gly Leu Glu Asn Ser Lys Ala Met Cys Val Leu Ala Gly Ser
     210                 215                 220                
 Asp His Ser Ala Ser Leu Thr Asp Ala Gly Glu Val Tyr Val Trp Gly
 225                 230                 235                 240
 Ser Asn Lys His Gly Gln Leu Ala Asn Glu Ala Ala Phe Leu Pro Val
                 245                 250                 255    
 Pro Gln Lys Ile Glu Ala His Cys Phe Gln Asn Glu Lys Val Thr Ala
             260                 265                 270        
 Ile Trp Ser Gly Trp Thr His Leu Val Ala Gln Thr Gly Leu Leu Trp
         275                 280                 285            
 Leu Arg Ser Ile Ile Leu Ala Ile Ile Gly Gly Val Cys Tyr Ser Trp
     290                 295                 300                
 Gly Cys Glu
 305        



      <210> 677
      <211> 119
      <212> PRT
      <213> Homo sapiens


      <400> 677
 Phe Ala Trp Thr Leu Gly Leu Ser Leu Ile Pro Ser Phe Gln Lys Leu
   1               5                  10                  15    
 His Val Pro Trp Glu Ala Glu Ser Leu Arg Thr Ser Trp Leu Cys Leu
              20                  25                  30        
 Gly Gly Ser Gly Leu Gln Leu Tyr Ala Glu Arg Leu Asn Thr Val Leu
          35                  40                  45            
 Glu Glu Met Gly Asn Arg Ile Glu Asp Leu Gln Lys Asn Val Asn Asp
      50                  55                  60                
 Leu Met Val Gln Ala Gly Ile Glu Asn Ser Ile Lys Glu Gln Met Leu
  65                  70                  75                  80
 Lys Thr Val Thr Ala Ala Cys Leu Tyr Leu Glu Met Gly Pro Leu Thr
                  85                  90                  95    
 Glu Val Ile Lys Val Thr Ser Gly Pro Glu Gly Gly Ala Leu Ile Gln
             100                 105                 110        
 Gln Asp Ser Ser Phe
         115        



      <210> 678
      <211> 78
      <212> PRT
      <213> Homo sapiens


      <400> 678
 Leu Leu Ile Ser Cys Leu Gly Thr Pro Gly Leu Ser Trp Ala Pro Lys
   1               5                  10                  15    
 Gly Ile Pro Asn Cys Ser Cys Thr Thr Gly Gly Ser Cys Ala Cys Ala
              20                  25                  30        
 Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Cys
          35                  40                  45            
 Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly Cys
      50                  55                  60                
 Val Cys Lys Gly Ser Ser Glu Lys Cys Arg Cys Cys Ala
  65                  70                  75        



      <210> 679
      <211> 433
      <212> PRT
      <213> Homo sapiens


      <400> 679
 Glu Arg Gly Pro Ile Pro Cys Gln Pro Leu Ser Leu Cys Gly Glu Lys
   1               5                  10                  15    
 Ala His Trp Leu Val Pro Leu Arg Asn Ser Arg Thr Gln Lys Arg Pro
              20                  25                  30        
 Ile Lys Asp Gly Ser Phe Ser Pro Pro Ala Arg Leu Leu Arg Pro Pro
          35                  40                  45            
 Thr Arg Gln Val Asp Asn Leu Asp Ser Ser Pro Gly Leu Ala Leu Leu
      50                  55                  60                
 Phe His Leu Leu Pro Pro Ser Tyr Thr Leu Pro Leu Ala Ala Arg Met
  65                  70                  75                  80
 Ala Arg Arg Arg Ser Gln Arg Val Cys Ala Ser Gly Pro Ser Met Leu
                  85                  90                  95    
 Asn Ser Ala Arg Gly Ala Pro Glu Leu Leu Arg Gly Thr Ala Thr Asn
             100                 105                 110        
 Ala Glu Val Ser Ala Ala Ala Ala Gly Ala Thr Gly Ser Glu Glu Leu
         115                 120                 125            
 Pro Pro Gly Asp Arg Gly Cys Arg Asn Gly Gly Gly Arg Gly Pro Ala
     130                 135                 140                
 Ala Thr Thr Ser Ser Thr Gly Val Ala Val Gly Ala Glu His Gly Glu
 145                 150                 155                 160
 Asp Ser Leu Ser Arg Lys Pro Asp Pro Glu Pro Gly Arg Met Asp His
                 165                 170                 175    
 His Gln Pro Gly Thr Gly Arg Tyr Gln Val Leu Leu Asn Glu Glu Asp
             180                 185                 190        
 Asn Ser Glu Ser Ser Ala Ile Glu Gln Pro Pro Thr Ser Asn Pro Ala
         195                 200                 205            
 Pro Gln Ile Val Gln Ala Ala Ser Ser Ala Pro Ala Leu Glu Thr Asp
     210                 215                 220                
 Ser Ser Pro Pro Pro Tyr Ser Ser Ile Thr Val Glu Val Pro Thr Thr
 225                 230                 235                 240
 Ser Asp Thr Glu Val Tyr Gly Glu Phe Tyr Pro Val Pro Pro Pro Tyr
                 245                 250                 255    
 Ser Val Ala Thr Ser Leu Pro Thr Tyr Asp Glu Ala Glu Lys Ala Lys
             260                 265                 270        
 Ala Ala Ala Met Ala Ala Ala Ala Ala Glu Thr Ser Pro Arg Ile Gln
         275                 280                 285            
 Glu Glu Glu Cys Pro Pro Arg Asp Asp Phe Cys Asp Ala Asp His Leu
     290                 295                 300                
 Lys Val Gly Asn Asp Gly Ile Leu Met Leu Ala Phe Phe Met Ala Phe
 305                 310                 315                 320
 Ile Phe Asn Trp Leu Gly Phe Cys Leu Ser Phe Cys Ile Thr Asn Thr
                 325                 330                 335    
 Ile Ala Gly Arg Tyr Gly Ala Ile Cys Gly Phe Gly Leu Ser Leu Ile
             340                 345                 350        
 Lys Trp Ile Leu Ile Val Arg Phe Ser Asp Tyr Phe Thr Gly Tyr Phe
         355                 360                 365            
 Asn Gly Gln Tyr Trp Leu Trp Trp Asp Ile Ser Leu Leu Leu Gly Pro
     370                 375                 380                
 Gly Phe Leu Phe Phe Gln Glu Gly Phe Val Asn Tyr Leu Lys Val Arg
 385                 390                 395                 400
 Asn Met Ser Glu Ser Met Ala Ala Ala His Arg Thr Arg Tyr Phe Phe
                 405                 410                 415    
 Leu Leu
        



      <210> 680
      <211> 295
      <212> PRT
      <213> Homo sapiens


      <400> 680
 Glu Leu Leu Phe Ser Ser Leu Arg Gly Leu Arg Gly Cys Leu Cys Phe
   1               5                  10                  15    
 Ser Ser Pro Leu Asn Gly Pro Pro Phe Ser Leu Gln Val Phe Pro Ile
              20                  25                  30        
 Lys His Tyr Gln Asp Lys Ile Arg Pro Tyr Ile Gln Leu Pro Ser His
          35                  40                  45            
 Ser Asn Ile Thr Gly Ile Val Glu Val Ile Leu Gly Glu Thr Lys Ala
      50                  55                  60                
 Tyr Val Phe Phe Glu Lys Asp Phe Gly Asp Met His Ser Tyr Val Arg
  65                  70                  75                  80
 Ser Arg Lys Arg Leu Arg Glu Glu Glu Ala Ala Arg Leu Phe Lys Gln
                  85                  90                  95    
 Ile Val Ser Ala Val Ala His Cys His Gln Ser Ala Ile Val Leu Gly
             100                 105                 110        
 Asp Leu Lys Leu Arg Lys Phe Val Phe Ser Thr Glu Glu Arg Thr Gln
         115                 120                 125            
 Leu Arg Leu Glu Ser Leu Glu Asp Thr His Ile Met Lys Gly Glu Asp
     130                 135                 140                
 Asp Ala Leu Ser Asp Lys His Gly Cys Pro Ala Tyr Val Ser Pro Glu
 145                 150                 155                 160
 Ile Leu Asn Thr Thr Gly Thr Tyr Ser Gly Lys Ala Ala Asp Val Trp
                 165                 170                 175    
 Thr Gly Gly Val Met Leu Tyr Thr Leu Leu Val Gly Arg Tyr Pro Phe
             180                 185                 190        
 His Asp Ser Asp Pro Ser Ala Leu Phe Ser Lys Ile Arg Arg Gly Gln
         195                 200                 205            
 Phe Cys Ile Pro Glu His Ile Ser Pro Lys Ala Arg Cys Leu Ile Arg
     210                 215                 220                
 Ser Leu Leu Arg Arg Glu Pro Ser Glu Arg Leu Thr Ala Pro Glu Ile
 225                 230                 235                 240
 Leu Leu His Pro Trp Phe Glu Ser Val Leu Glu Pro Gly Tyr Ile Asp
                 245                 250                 255    
 Ser Glu Ile Gly Thr Ser Asp Gln Ile Val Pro Glu Tyr Gln Glu Asp
             260                 265                 270        
 Ser Asp Ile Ser Ser Phe Phe Leu Leu Asn Pro Gln Asn Leu Gln Glu
         275                 280                 285            
 Thr Ser
     290



      <210> 681
      <211> 97
      <212> PRT
      <213> Homo sapiens


      <400> 681
 Lys Leu Pro Ser Leu Ile His Gly Gly Gln Met Lys Val Lys Gly Ser
   1               5                  10                  15    
 Asn Thr Thr Tyr Lys Asp Cys Gln Val Trp Pro Gly Gly Ser Arg Thr
              20                  25                  30        
 Trp Asp Trp Arg Glu Thr Gly Thr Glu His Ser Pro Gly Val Cys Ser
          35                  40                  45            
 Leu Gln Pro Ala Asp Val Lys Glu Val Val Glu Lys Gly Val Gln Thr
      50                  55                  60                
 Leu Val Ile Gly Arg Gly Met Ser Glu Ala Leu Lys Val Pro Ser Ser
  65                  70                  75                  80
 Thr Val Glu Tyr Leu Lys Glu Thr Trp His
                  85                  90



      <210> 682
      <211> 1379
      <212> PRT
      <213> Homo sapiens


      <400> 682
 Ile Leu Ser Cys Ser Leu Ser Ser Gln Val Gly Leu Thr Ser Val Thr
   1               5                  10                  15    
 Ser Ile Gln Glu Arg Ile Met Ser Thr Pro Gly Gly Glu Glu Ala Ile
              20                  25                  30        
 Glu Arg Leu Lys Glu Ser Glu Lys Ile Ile Val Glu Leu Asn Glu Thr
          35                  40                  45            
 Trp Glu Glu Lys Leu Arg Lys Thr Glu Ala Ile Lys Met Glu Arg Glu
      50                  55                  60                
 Ala Leu Leu Ala Glu Met Gly Val Ala Ile Arg Glu Asp Gly Gly Thr
  65                  70                  75                  80
 Leu Gly Val Phe Ser Pro Lys Lys Thr Pro His Leu Val Asn Leu Asn
                  85                  90                  95    
 Glu Asp Pro Leu Met Ser Glu Cys Leu Leu Tyr Tyr Ile Lys Asp Gly
             100                 105                 110        
 Ile Thr Arg Val Gly Gln Ala Asp Ala Glu Arg Arg Gln Asp Ile Val
         115                 120                 125            
 Leu Ser Gly Ala His Ile Lys Glu Glu His Cys Ile Phe Arg Ser Glu
     130                 135                 140                
 Arg Ser Asn Ser Gly Glu Val Ile Val Thr Leu Glu Pro Cys Glu Arg
 145                 150                 155                 160
 Ser Glu Thr Tyr Val Asn Gly Lys Arg Val Ser Gln Pro Val Gln Leu
                 165                 170                 175    
 Arg Ser Gly Asn Arg Ile Ile Met Gly Lys Asn His Val Phe Arg Phe
             180                 185                 190        
 Asn His Pro Glu Gln Ala Arg Ala Glu Arg Glu Lys Thr Pro Ser Ala
         195                 200                 205            
 Glu Thr Pro Ser Glu Pro Val Asp Trp Thr Phe Ala Gln Arg Glu Leu
     210                 215                 220                
 Leu Glu Lys Gln Gly Ile Asp Met Lys Gln Glu Met Glu Lys Arg Leu
 225                 230                 235                 240
 Gln Glu Met Glu Ile Leu Tyr Lys Lys Glu Lys Glu Glu Ala Asp Leu
                 245                 250                 255    
 Leu Leu Glu Gln Gln Arg Leu Asp Tyr Glu Ser Lys Leu Gln Ala Leu
             260                 265                 270        
 Gln Lys Gln Val Glu Thr Arg Ser Leu Ala Ala Glu Thr Thr Glu Glu
         275                 280                 285            
 Glu Glu Glu Glu Glu Glu Val Pro Trp Thr Gln His Glu Phe Glu Leu
     290                 295                 300                
 Ala Gln Trp Ala Phe Arg Lys Trp Lys Ser His Gln Phe Thr Ser Leu
 305                 310                 315                 320
 Arg Asp Leu Leu Trp Gly Asn Ala Val Tyr Leu Lys Glu Ala Asn Ala
                 325                 330                 335    
 Ile Ser Val Glu Leu Lys Lys Lys Val Gln Phe Gln Phe Val Leu Leu
             340                 345                 350        
 Thr Asp Thr Leu Tyr Ser Pro Leu Pro Pro Glu Leu Leu Pro Thr Glu
         355                 360                 365            
 Met Glu Lys Thr His Glu Asp Arg Pro Phe Pro Arg Thr Val Val Ala
     370                 375                 380                
 Val Glu Val Gln Asp Leu Lys Asn Gly Ala Thr His Tyr Trp Ser Leu
 385                 390                 395                 400
 Glu Lys Leu Lys Gln Arg Leu Asp Leu Met Arg Glu Met Tyr Asp Arg
                 405                 410                 415    
 Ala Gly Glu Met Ala Ser Ser Ala Gln Asp Glu Ser Glu Thr Thr Val
             420                 425                 430        
 Thr Gly Ser Asp Pro Phe Tyr Asp Arg Phe His Trp Phe Lys Leu Val
         435                 440                 445            
 Gly Ser Ser Pro Ile Phe His Gly Cys Val Asn Lys Arg Leu Ala Asp
     450                 455                 460                
 Arg Thr Pro Ser Pro Thr Phe Ser Thr Ala Asp Ser Asp Ile Thr Glu
 465                 470                 475                 480
 Leu Ala Ala Asp Gln Gln Asp Glu Met Glu Val Phe Asp Asp Glu Ala
                 485                 490                 495    
 Phe Val Asp Asp Ala Gly Ser Asp Ala Gly Thr Glu Glu Gly Ser Asp
             500                 505                 510        
 Leu Phe Ser Asp Gly His Asp Pro Phe Tyr Asp Arg Ser Pro Trp Phe
         515                 520                 525            
 Ile Leu Val Gly Arg Ala Phe Val Tyr Leu Ser Asn Leu Leu Tyr Pro
     530                 535                 540                
 Val Pro Leu Ile His Arg Val Ala Ile Val Ser Glu Lys Gly Glu Val
 545                 550                 555                 560
 Arg Gly Phe Leu Arg Val Ala Val Gln Ala Ile Ala Ala Asp Glu Glu
                 565                 570                 575    
 Ala Pro Asp Tyr Gly Ser Gly Ile Arg Gln Ser Gly Thr Ala Lys Ile
             580                 585                 590        
 Ser Phe Asp Asn Glu Tyr Phe Asn Gln Ser Asp Phe Ser Ser Val Ala
         595                 600                 605            
 Met Thr Arg Ser Gly Leu Ser Leu Glu Glu Leu Arg Ile Val Glu Gly
     610                 615                 620                
 Gln Gly Gln Ser Ser Glu Val Ile Thr Pro Pro Glu Glu Ile Ser Arg
 625                 630                 635                 640
 Ile Asn Asp Leu Asp Leu Lys Ser Ser Thr Leu Leu Asp Gly Lys Met
                 645                 650                 655    
 Val Met Glu Gly Phe Ser Glu Glu Ile Gly Asn His Leu Lys Leu Gly
             660                 665                 670        
 Ser Ala Phe Thr Phe Arg Val Thr Val Leu Gln Ala Ser Gly Ile Leu
         675                 680                 685            
 Pro Glu Tyr Ala Asp Ile Phe Cys Gln Phe Asn Phe Leu His Arg His
     690                 695                 700                
 Asp Glu Ala Phe Ser Thr Glu Pro Leu Lys Asn Asn Gly Arg Gly Ser
 705                 710                 715                 720
 Pro Leu Ala Phe Tyr His Val Gln Asn Ile Ala Val Glu Ile Thr Glu
                 725                 730                 735    
 Ser Phe Val Asp Tyr Ile Lys Thr Lys Pro Ile Val Phe Glu Val Phe
             740                 745                 750        
 Gly His Tyr Gln Gln His Pro Leu His Leu Gln Gly Gln Glu Leu Asn
         755                 760                 765            
 Ser Pro Pro Gln Pro Cys Arg Arg Phe Phe Pro Pro Pro Met Pro Leu
     770                 775                 780                
 Ser Lys Pro Val Pro Ala Thr Lys Leu Asn Thr Met Ser Lys Thr Ser
 785                 790                 795                 800
 Leu Gly Gln Ser Met Ser Lys Tyr Asp Leu Leu Val Trp Phe Glu Ile
                 805                 810                 815    
 Ser Glu Leu Glu Pro Thr Gly Glu Tyr Ile Pro Ala Val Val Asp His
             820                 825                 830        
 Thr Ala Gly Leu Pro Cys Gln Gly Thr Phe Leu Leu His Gln Gly Ile
         835                 840                 845            
 Gln Arg Arg Ile Thr Val Thr Ile Ile His Glu Lys Gly Ser Glu Leu
     850                 855                 860                
 His Trp Lys Asp Val Arg Glu Leu Val Val Gly Arg Ile Arg Asn Lys
 865                 870                 875                 880
 Pro Glu Val Asp Glu Ala Ala Val Asp Ala Ile Leu Ser Leu Asn Ile
                 885                 890                 895    
 Ile Ser Ala Lys Tyr Leu Lys Ser Ser His Asn Ser Ser Arg Thr Phe
             900                 905                 910        
 Tyr Arg Phe Glu Ala Val Trp Asp Ser Ser Leu His Asn Ser Leu Leu
         915                 920                 925            
 Leu Asn Arg Val Thr Pro Tyr Gly Glu Lys Ile Tyr Met Thr Leu Ser
     930                 935                 940                
 Ala Tyr Leu Glu Leu Asp His Cys Ile Gln Pro Ala Val Ile Thr Lys
 945                 950                 955                 960
 Asp Val Cys Met Val Phe Tyr Ser Arg Asp Ala Lys Ile Ser Pro Pro
                 965                 970                 975    
 Arg Ser Leu Arg Ser Leu Phe Gly Ser Gly Tyr Ser Lys Ser Pro Asp
             980                 985                 990        
 Ser Asn Arg Val Thr Gly Ile Tyr Glu Leu Ser Leu Cys Lys Met Ser
         995                1000                1005            
 Asp Thr Gly Ser Pro Gly Met Gln Arg Arg Arg Arg Lys Ile Leu Asp
    1010                1015                1020                
 Thr Ser Val Ala Tyr Val Arg Gly Glu Glu Asn Leu Ala Gly Trp Arg
1025                1030                1035                1040
 Pro Arg Gly Asp Ser Leu Ile Leu Glu His Gln Trp Glu Leu Glu Lys
                1045                1050                1055    
 Leu Glu Leu Leu His Glu Val Glu Lys Thr Arg His Phe Leu Leu Leu
            1060                1065                1070        
 Arg Glu Arg Leu Gly Asp Ser Ile Pro Lys Ser Leu Ser Asp Ser Leu
        1075                1080                1085            
 Ser Pro Ser Leu Ser Ser Gly Thr Leu Ser Thr Ser Thr Ser Ile Ser
    1090                1095                1100                
 Ser Gln Ile Ser Thr Thr Thr Phe Glu Ser Ala Ile Thr Pro Ser Glu
1105                1110                1115                1120
 Ser Ser Gly Tyr Asp Ser Gly Asp Ile Glu Ser Leu Val Asp Arg Glu
                1125                1130                1135    
 Lys Glu Leu Ala Thr Lys Cys Leu Gln Leu Leu Thr His Thr Phe Asn
            1140                1145                1150        
 Arg Glu Phe Ser Gln Val His Gly Ser Val Ser Asp Cys Lys Leu Ser
        1155                1160                1165            
 Asp Ile Ser Pro Ile Gly Arg Asp Pro Ser Glu Ser Ser Phe Ser Ser
    1170                1175                1180                
 Ala Thr Leu Thr Pro Ser Ser Thr Cys Pro Ser Leu Val Asp Ser Arg
1185                1190                1195                1200
 Ser Asn Ser Leu Asp Gln Lys Thr Pro Glu Ala Asn Ser Arg Ala Ser
                1205                1210                1215    
 Ser Pro Cys Pro Glu Phe Glu Gln Phe Gln Ile Val Pro Ala Val Glu
            1220                1225                1230        
 Thr Pro Tyr Leu Ala Arg Ala Gly Lys Asn Glu Phe Leu Asn Leu Val
        1235                1240                1245            
 Pro Asp Ile Glu Glu Ile Arg Pro Ser Ser Val Val Ser Lys Lys Gly
    1250                1255                1260                
 Tyr Leu His Phe Lys Glu Pro Leu Tyr Ser Asn Trp Ala Lys His Phe
1265                1270                1275                1280
 Val Val Val Arg Arg Pro Tyr Val Phe Ile Tyr Asn Ser Asp Lys Asp
                1285                1290                1295    
 Pro Val Glu Arg Gly Ile Ile Asn Leu Ser Thr Ala Gln Val Glu Tyr
            1300                1305                1310        
 Ser Glu Asp Gln Gln Ala Met Val Lys Thr Pro Asn Thr Phe Ala Val
        1315                1320                1325            
 Cys Thr Lys His Arg Gly Val Leu Leu Gln Ala Leu Asn Asp Lys Asp
    1330                1335                1340                
 Met Asn Asp Trp Leu Tyr Ala Phe Asn Pro Leu Leu Ala Gly Thr Ile
1345                1350                1355                1360
 Arg Ser Lys Leu Ser Arg Arg Cys Pro Ser Gln Ser Lys Tyr
                1365                1370                



      <210> 683
      <211> 244
      <212> PRT
      <213> Homo sapiens


      <400> 683
 Arg Arg Cys Ser Arg Arg Leu Ala Gly Val Arg Ala Met Glu Arg Tyr
   1               5                  10                  15    
 Ala Gly Ala Leu Glu Glu Val Ala Asp Gly Ala Arg Gln Gln Glu Arg
              20                  25                  30        
 His Tyr Gln Leu Leu Ser Ala Leu Gln Ser Leu Val Lys Glu Leu Pro
          35                  40                  45            
 Ser Ser Phe Gln Gln Arg Leu Ser Tyr Thr Thr Leu Ser Asp Leu Ala
      50                  55                  60                
 Leu Ala Leu Leu Asp Gly Thr Val Phe Glu Ile Val Gln Gly Leu Leu
  65                  70                  75                  80
 Glu Ile Gln His Leu Thr Glu Lys Ser Leu Tyr Asn Gln Arg Leu Arg
                  85                  90                  95    
 Leu Gln Asn Glu His Arg Val Leu Arg Gln Ala Leu Arg Gln Lys His
             100                 105                 110        
 Gln Glu Ala Gln Gln Ala Cys Arg Pro His Asn Leu Pro Val Leu Gln
         115                 120                 125            
 Ala Ala Gln Gln Arg Glu Leu Glu Ala Val Glu His Arg Ile Arg Glu
     130                 135                 140                
 Glu Gln Arg Ala Met Asp Gln Lys Ile Ile Leu Glu Leu Asp Arg Lys
 145                 150                 155                 160
 Val Ala Asp Gln Gln Ser Thr Leu Glu Lys Ala Gly Gly Gly Leu Gly
                 165                 170                 175    
 Ser Tyr Val Thr Thr Asn Pro Gln Glu Leu Met Leu His Asp Glu Pro
             180                 185                 190        
 Cys Trp Asn Ile Ile Arg Lys Ala Ala Ala Asp Trp Ala Ala Gly Ala
         195                 200                 205            
 Gly Ile Cys Ser Pro Gly Thr Gly Glu Val Pro Trp Gln Leu Pro Ser
     210                 215                 220                
 Ala Gln Cys Asp Gln Lys Gly Ser Pro Val Pro Pro
 225                 230                 235    



      <210> 684
      <211> 122
      <212> PRT
      <213> Homo sapiens


      <400> 684
 Asp Leu Ala Trp Val Glu Met Ile Val His Pro Val Leu Asp Ser Pro
   1               5                  10                  15    
 Asn Ala Val His Glu Val Glu Lys Trp Leu Pro Arg Leu His Ala Leu
              20                  25                  30        
 Val Val Gly Thr Gly Leu Gly Arg Asp Asp Ala Leu Leu Arg Asn Val
          35                  40                  45            
 Gln Gly Ile Phe Glu Val Ser Lys Ala Arg Asp Ile Pro Val Val Ile
      50                  55                  60                
 Asp Ala Asp Gly Leu Trp Leu Val Ala Gln Gln Pro Ala Leu Ile His
  65                  70                  75                  80
 Gly Tyr Arg Lys Ala Val Leu Thr Pro Asn His Val Glu Phe Ser Arg
                  85                  90                  95    
 Leu Tyr Asp Ala Val Leu Arg Gly Pro Met Asp Ser Asp Asp Ser Gln
             100                 105                 110        
 Trp Ile Cys Cys
         115    



      <210> 685
      <211> 385
      <212> PRT
      <213> Homo sapiens


      <400> 685
 Ser Trp Asn Arg Cys Arg Arg Arg Thr Ala Val Ile Leu Ser Arg Pro
   1               5                  10                  15    
 Ser Trp Leu Trp Gly Ala Glu Ile Gly Pro Pro Thr Lys His Gly Val
              20                  25                  30        
 Cys Ile Gly Asn Glu Ala Val Trp Thr Lys Glu Pro Val Gly Glu Gly
          35                  40                  45            
 Glu Thr Leu Val Gly Met Asp Leu Thr Gln Leu Ala Leu Glu Arg Ser
      50                  55                  60                
 Ser Ser Ala Gln Glu Ala Leu Asp Gly Asn Thr Lys Val Thr Glu Pro
  65                  70                  75                  80
 Leu Ile Gly Gln Gly Gly Asn Cys Leu Glu Asp Ala Ala Pro Phe Ser
                  85                  90                  95    
 Tyr His Ser Thr Phe Leu Leu Ala Asp Arg Thr Glu Ala Trp Val Leu
             100                 105                 110        
 Glu Thr Ala Gly Arg Leu Trp Ala Ala Gln Arg Ile Gln Glu Gly Ala
         115                 120                 125            
 Arg Thr Ile Ser Asn Gln Leu Ser Ile Gly Thr Asp Ile Ser Ala Gln
     130                 135                 140                
 His Pro Glu Leu Arg Thr His Ala Gln Ala Lys Gly Trp Trp Asn Gly
 145                 150                 155                 160
 Gln Gly Ala Phe Asp Phe Ala Gln Ile Phe Ser Leu Thr Gln Gln Pro
                 165                 170                 175    
 Gly Ala His Gly Gly Cys Gln Gly Pro Leu Pro Gly Arg Ala Gly Ala
             180                 185                 190        
 Ala Ala Ala Thr Ala Ser Phe Pro Leu Tyr Ser Leu Ala Gly Gly Ile
         195                 200                 205            
 Thr Ala Glu Val Met Met Gly Ile Leu Arg Asp Lys Glu Ser Gly Ile
     210                 215                 220                
 Cys Met Asp Ser Gly Gly Phe Arg Thr Thr Ala Ser Met Val Ser Val
 225                 230                 235                 240
 Leu Pro Gln Asn Pro Thr Gln Pro Cys Val His Phe Leu Thr Ala Thr
                 245                 250                 255    
 Pro Asp Pro Ser Arg Ser Val Phe Lys Pro Phe Ile Phe Gly Met Gly
             260                 265                 270        
 Val Ala Gln Gly Pro Arg Val Leu Ser Pro Thr Phe Gly Ala Gln Asp
         275                 280                 285            
 Pro Val Arg Thr Leu Pro Arg Phe Gln Thr Gln Val Asp Arg Arg His
     290                 295                 300                
 Thr Leu Leu Pro Trp Asp Thr Arg Ala Ala Leu Gly Leu Met Glu Arg
 305                 310                 315                 320
 Asp Gln Asp Trp Gly Arg Gln Leu Gln Gln Lys Arg Gln Asp Leu Glu
                 325                 330                 335    
 Gln Glu Gly Leu Glu Ala Thr Gln Gly Val Leu Ala Gly Glu Trp Ala
             340                 345                 350        
 Pro Pro Leu Trp Glu Leu Gly Ser Leu Phe Gln Ala Phe Val Lys Arg
         355                 360                 365            
 Glu Ser Gln Ala Tyr Ala
     370                



      <210> 686
      <211> 400
      <212> PRT
      <213> Homo sapiens


      <400> 686
 Gln Ile Trp Phe Trp Lys Asn Gln Ser Gly Gly Pro Tyr Glu Lys Lys
   1               5                  10                  15    
 Glu Leu Ser Glu Asn Lys Tyr Ser Pro Ser Thr Thr Leu Gly Ile Cys
              20                  25                  30        
 Trp Pro Arg Thr Phe Tyr Leu Lys Lys Asn Glu Lys Gln Lys Lys Arg
          35                  40                  45            
 Lys Asn Gln Met Glu Ile Pro Thr Ile Gly Trp Gly Gly Gln Met Thr
      50                  55                  60                
 Pro Tyr Tyr Pro Val Gly Met Gly Asn Gly Thr Pro Cys Ser Leu Lys
  65                  70                  75                  80
 Gln Asn Arg Pro Arg Ser Ser Thr Val Met Tyr Ile Cys His Pro Glu
                  85                  90                  95    
 Ser Lys His Glu Ile Leu Ser Val Ala Glu Val Thr Thr Cys Glu Tyr
             100                 105                 110        
 Glu Val Val Ile Leu Thr Pro Leu Leu Val Gln Phe Ile Leu Lys Tyr
         115                 120                 125            
 Arg Phe Arg Ser Ile Ser Arg Trp Asn Gly His Ile Leu Val Lys Ser
     130                 135                 140                
 Leu Pro Gly Ser Pro Phe Lys Pro Leu Thr Leu Arg Gln Leu Glu Gln
 145                 150                 155                 160
 Gln Glu Glu Ile Leu Arg Val Pro Phe Arg Arg Asn Lys Glu Glu Asp
                 165                 170                 175    
 Leu Gln Ser Thr Lys Glu Glu Arg Phe Pro Ala Ile His Lys Ser Pro
             180                 185                 190        
 Ile Ala Ile Gly Ser Gln Pro Val Leu Thr Val Gly Thr Thr His Ile
         195                 200                 205            
 Ser Lys Leu Thr Asp Asp Gln Leu Ile Lys Glu Phe Leu Ser Gly Ser
     210                 215                 220                
 Tyr Cys Phe Arg Gly Gly Val Gly Trp Trp Lys Tyr Glu Phe Cys Tyr
 225                 230                 235                 240
 Gly Lys His Val His Gln Tyr His Glu Asp Lys Asp Ser Gly Lys Thr
                 245                 250                 255    
 Leu Cys Gly Leu Ser Gly Pro Trp Asn Gln Glu Glu His Ile Glu Trp
             260                 265                 270        
 Ala Lys Lys Asn Thr Cys Leu Glu Pro Tyr His Leu Gln Asp Asp Gly
         275                 280                 285            
 Thr Pro Asp Gln Ser Gly Met Gly Val Ser His Phe Tyr Gly Asn Gly
     290                 295                 300                
 Asp Ile Cys Asp Ile Thr Asp Lys Pro Arg Gln Val Thr Val Lys Leu
 305                 310                 315                 320
 Lys Cys Lys Glu Ser Asp Ser Pro His Ala Val Thr Val Tyr Met Leu
                 325                 330                 335    
 Glu Pro His Ser Cys Gln Tyr Ile Leu Gly Gly Leu Asn Leu Pro Val
             340                 345                 350        
 Ile Cys Lys Ile Leu Asp Thr Ser Arg Met Lys Asn Gly Leu Pro Phe
         355                 360                 365            
 Ser Ser Pro Thr
     370        



      <210> 687
      <211> 94
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(94)
      <223> Xaa = any amino acid or nothing 


      <400> 687
 Lys Thr Thr Glu Leu Leu Leu Arg Met Gly Leu Thr Leu Pro Ser Pro
   1               5                  10                  15    
 Arg Leu Glu Cys Gly Gly Thr Ile Met Ala His Cys Ser Leu Glu Leu
              20                  25                  30        
 Leu Ser Ser Ser His Pro Pro Thr Ser Ala Phe Arg Val Ala Gly Thr
          35                  40                  45            
 Ala Gly Val Ser His His Ala Trp Leu Asp Leu Ser Phe Xaa Ile Phe
      50                  55                  60                
 Tyr Arg Asp Arg Val Ser Thr Ile Leu Val Gln Gly Trp Lys Arg Thr
  65                  70                  75                  80
 Ser Phe Pro Pro Ser Asp Asn Leu Phe Pro Asp Lys Ser Ala
                  85                  90                



      <210> 688
      <211> 106
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(106)
      <223> Xaa = any amino acid or nothing 


      <400> 688
 Gly Gly Ala Gly Leu Lys Lys Asn Phe Gly Gly Ala His Phe Tyr Pro
   1               5                  10                  15    
 Gly Arg Pro Gln Gly Val Tyr Leu Phe Leu Phe Gly Gly Gly Ile Lys
              20                  25                  30        
 Xaa His Pro Trp Tyr Gln Asn Met Phe Asn Trp Asn Leu Trp Leu Thr
          35                  40                  45            
 Thr Leu Ile Thr Gly Leu Ala Gly Pro Leu Leu Leu Leu Leu Leu Gly
      50                  55                  60                
 Leu Val Phe Gly Pro Cys Ile Leu Asn Trp Phe Leu Lys Phe Ile Lys
  65                  70                  75                  80
 Gln Phe Ile Ala Ser Val Lys Leu Thr Tyr Leu Lys Thr Gln Tyr Asn
                  85                  90                  95    
 Ser Leu Val Val Thr Glu Glu Ser Met Ile
             100                 105    



      <210> 689
      <211> 115
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(115)
      <223> Xaa = any amino acid or nothing 


      <400> 689
 Ile Trp Ser Ile Val Ser Trp Pro Ser Pro Pro Ala Leu Cys Pro Trp
   1               5                  10                  15    
 Asn Ser Cys Thr Ser Pro Lys Met Ser Asp Ala Asp Val Glu Lys Ala
              20                  25                  30        
 Ala Lys Asp Val Thr His Leu Lys Thr Ile Pro Ser Asp Glu Glu Met
          35                  40                  45            
 Leu Leu Ile Tyr Gly His Tyr Tyr Gln Ala Thr Gly Gly Asp Ile Asn
      50                  55                  60                
 Thr Glu Arg Ala Gly Met Leu Asp Phe Thr Gly Asn Asp Thr Trp Asp
  65                  70                  75                  80
 Ala Trp Asn Glu Leu Lys Gly Thr Ser Lys Glu Asp Ala Met Leu Ala
                  85                  90                  95    
 Tyr Ile Ser Lys Val Val Xaa Leu Leu Lys Lys Tyr Gly Ile Leu Arg
             100                 105                 110        
 Asp Trp Thr
         115



      <210> 690
      <211> 110
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(110)
      <223> Xaa = any amino acid or nothing 


      <400> 690
 Gly Ser Cys Trp Cys Glu Met Thr Glu Tyr Lys Leu Val Val Val Gly
   1               5                  10                  15    
 Ala Gly Gly Val Gly Lys Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn
              20                  25                  30        
 His Phe Val Asp Glu Tyr Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys
          35                  40                  45            
 Gln Val Val Ile Asp Gly Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr
      50                  55                  60                
 Ala Gly Gln Glu Glu Tyr Ser Ala Met Arg Asp Gln Tyr Met Arg Thr
  65                  70                  75                  80
 Gly Glu Gly Phe Leu Cys Val Phe Ala Ile Asn Asn Ser Lys Ser Phe
                  85                  90                  95    
 Ala Asp Ile Asn Leu Tyr Arg Tyr Xaa Glu His Tyr Phe Leu
             100                 105                 110



      <210> 691
      <211> 407
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(407)
      <223> Xaa = any amino acid or nothing 


      <400> 691
 Ser Cys Gly Ser Glu Ala Asp Tyr Pro Ala Ala Ala Arg Leu Ala Val
   1               5                  10                  15    
 Leu Leu Ser Met Asp Arg Thr Cys Glu Glu Arg Pro Ala Glu Asp Gly
              20                  25                  30        
 Ser Asp Glu Glu Asp Pro Asp Ser Met Glu Ala Pro Thr Arg Ile Arg
          35                  40                  45            
 Asp Thr Pro Glu Asp Ile Val Leu Glu Ala Pro Ala Ser Gly Leu Ala
      50                  55                  60                
 Phe His Pro Ala Arg Asp Leu Leu Ala Ala Gly Asp Val Asp Gly Asp
  65                  70                  75                  80
 Val Phe Val Phe Ser Tyr Ser Cys Gln Glu Gly Glu Thr Lys Glu Leu
                  85                  90                  95    
 Trp Ser Ser Gly His His Leu Lys Ala Cys Arg Ala Val Ala Phe Ser
             100                 105                 110        
 Glu Asp Gly Gln Lys Leu Ile Thr Val Ser Lys Asp Lys Ala Ile His
         115                 120                 125            
 Val Leu Asp Val Glu Gln Gly Gln Leu Glu Arg Arg Val Ser Lys Ala
     130                 135                 140                
 His Gly Ala Pro Ile Asn Ser Leu Leu Leu Val Asp Glu Asn Val Leu
 145                 150                 155                 160
 Ala Thr Gly Asp Asp Thr Gly Gly Ile Arg Leu Trp Asp Gln Arg Lys
                 165                 170                 175    
 Glu Gly Pro Leu Met Asp Met Arg Gln His Glu Glu Tyr Ile Ala Asp
             180                 185                 190        
 Met Ala Leu Asp Pro Ala Lys Lys Leu Leu Leu Thr Ala Ser Gly Asp
         195                 200                 205            
 Gly Cys Leu Gly Ile Phe Asn Ile Lys Arg Arg Arg Phe Glu Leu Leu
     210                 215                 220                
 Ser Glu Pro Gln Ala Gly Asp Leu Ser Ser Val Thr Leu Met Lys Trp
 225                 230                 235                 240
 Gly Lys Lys Val Ala Cys Gly Ser Ser Glu Gly Thr Ile Tyr Leu Phe
                 245                 250                 255    
 Asn Trp Asn Gly Phe Gly Ala Thr Ser Asp Arg Phe Ala Leu Arg Ala
             260                 265                 270        
 Glu Ser Ile Asp Cys Met Val Pro Val Thr Glu Ser Leu Leu Cys Thr
         275                 280                 285            
 Gly Ser Thr Asp Gly Val Ile Arg Ala Val Asn Ile Leu Pro Asn Arg
     290                 295                 300                
 Val Val Gly Ser Val Gly Gln His Thr Gly Glu Pro Val Glu Glu Leu
 305                 310                 315                 320
 Ala Leu Ser His Cys Gly Arg Phe Leu Ala Ser Ser Gly His Asp Gln
                 325                 330                 335    
 Arg Leu Lys Phe Trp Asp Met Ala Gln Leu Ala Ser Cys Gly Gly Gly
             340                 345                 350        
 Xaa Leu Pro Ser Ala Gln Lys Lys Gly Arg Thr Thr Ala Gly Ser Glu
         355                 360                 365            
 Gln Gln Asp Leu Glu His Arg Xaa Leu Leu Arg Arg Thr Glu Ala Arg
     370                 375                 380                
 Gly Arg Ser Leu His Gly Ser Gln Lys Lys Arg Arg Arg Leu Gly Met
 385                 390                 395                 400
 Thr Val Thr Glu Gly Met Asn
                 405        



      <210> 692
      <211> 106
      <212> PRT
      <213> Homo sapiens


      <400> 692
 Ser Ser Tyr Leu Glu Gly Leu Gln Gly Arg Val Thr Thr Val Asp Leu
   1               5                  10                  15    
 Arg Asp Glu Ser Val Ala His Gly Arg Ile Tyr Asn Gly Asp Ala Phe
              20                  25                  30        
 Met Asn Ile Arg Leu Ala Lys Val Thr Tyr Thr Asp Arg Trp Gly His
          35                  40                  45            
 Gln Val Lys Leu Asp Asp Leu Phe Val Thr Gly Arg Asn Val Arg Tyr
      50                  55                  60                
 Val His Ile Pro Asp Asp Val Asn Ile Thr Ser Thr Ile Glu Gln Gln
  65                  70                  75                  80
 Leu Gln Ile Ile His Arg Val Arg Asn Phe Gly Gly Lys Gly Gln Gly
                  85                  90                  95    
 Arg Trp Glu Phe Pro Pro Lys Asn Cys Lys
             100                 105    



      <210> 693
      <211> 178
      <212> PRT
      <213> Homo sapiens


      <400> 693
 Leu Ser Thr Leu Ile Thr Met Lys Ile Tyr Lys Asp Leu Ile Thr Asp
   1               5                  10                  15    
 Asp Glu Leu Phe Ser Asp Thr Tyr Pro Met Lys Leu Ile Asp Gly Val
              20                  25                  30        
 Ile Tyr Glu Val Thr Gly Arg Leu Val Thr Arg Lys Val Gly Asp Val
          35                  40                  45            
 Gln Leu Ile Gly Ser Asn Pro Ser Ala Glu Asp Val Asp Glu Gly Thr
      50                  55                  60                
 Glu Glu Ala Val Glu Ser Gly Cys Asp Ile Val Leu Asn His Arg Leu
  65                  70                  75                  80
 Gln Glu Ser Tyr Ala Phe Gly Asp Lys Lys Gly Tyr Thr Leu Tyr Leu
                  85                  90                  95    
 Lys Glu Tyr Met Lys Arg Ile Val Asp Lys Leu Gln Glu Thr Asn Pro
             100                 105                 110        
 Ser Glu Val Asp Thr Phe Lys Thr Asn Ile Asn Lys Tyr Met Lys Asp
         115                 120                 125            
 Val Leu Gly Arg Phe Lys Asp Leu Gln Phe Phe Thr Gly Glu Ser Thr
     130                 135                 140                
 Asp Ile Asp Gly Met Val Ala Leu Leu Glu Tyr Arg Asp Leu Asn Gly
 145                 150                 155                 160
 Glu Ser Arg Pro Val Met Met Phe Phe Lys His Gly Leu Ile Gln Glu
                 165                 170                 175    
 Lys Cys
        



      <210> 694
      <211> 87
      <212> PRT
      <213> Homo sapiens


      <400> 694
 Ser Arg Asn Ser Ala Arg Gly Asn Met Leu Ala Leu Arg Gln Ile Ala
   1               5                  10                  15    
 Gln Arg Thr Ile Ser Thr Thr Ser Arg Arg His Phe Glu Asn Lys Val
              20                  25                  30        
 Pro Glu Lys Gln Lys Leu Phe Gln Glu Asp Asn Gly Met Pro Val His
          35                  40                  45            
 Leu Lys Gly Gly Ala Ser Asp Ala Leu Leu Tyr Arg Ala Thr Met Ala
      50                  55                  60                
 Leu Thr Leu Gly Gly Thr Ala Tyr Ala Ile Tyr Leu Leu Ala Met Ala
  65                  70                  75                  80
 Ala Phe Pro Lys Lys Gln Asn
                  85        



      <210> 695
      <211> 357
      <212> PRT
      <213> Homo sapiens


      <400> 695
 Ile Gly Glu Phe Cys Trp Arg Cys Ser Cys Arg Met Val Gly Gly Gly
   1               5                  10                  15    
 Gly Lys Arg Arg Pro Gly Gly Glu Gly Pro Gln Cys Glu Lys Thr Thr
              20                  25                  30        
 Asp Val Lys Lys Ser Lys Phe Cys Glu Ala Asp Val Ser Ser Asp Leu
          35                  40                  45            
 Arg Lys Glu Val Glu Asn His Tyr Lys Leu Ser Leu Pro Glu Asp Phe
      50                  55                  60                
 Tyr His Phe Trp Lys Phe Cys Glu Glu Leu Asp Pro Glu Lys Pro Ser
  65                  70                  75                  80
 Asp Ser Leu Ser Ala Ser Leu Gly Leu Gln Leu Val Gly Pro Tyr Asp
                  85                  90                  95    
 Ile Leu Ala Gly Lys His Lys Thr Lys Lys Lys Ser Thr Gly Leu Asn
             100                 105                 110        
 Phe Asn Leu His Trp Arg Phe Tyr Tyr Asp Pro Pro Glu Phe Gln Thr
         115                 120                 125            
 Ile Ile Ile Gly Asp Asn Lys Thr Gln Tyr His Met Gly Tyr Phe Arg
     130                 135                 140                
 Asp Ser Pro Asp Glu Phe Pro Val Tyr Val Gly Ile Asn Glu Ala Lys
 145                 150                 155                 160
 Lys Asn Cys Ile Ile Val Pro Asn Gly Asp Asn Val Phe Ala Ala Val
                 165                 170                 175    
 Lys Leu Phe Leu Thr Lys Lys Leu Lys Glu Ile Thr Asp Lys Lys Lys
             180                 185                 190        
 Ile Asn Leu Leu Lys Asn Ile Asp Glu Lys Leu Thr Glu Ala Ala Arg
         195                 200                 205            
 Glu Leu Gly Tyr Ser Leu Glu Gln Arg Thr Val Lys Met Lys Gln Arg
     210                 215                 220                
 Asp Lys Lys Val Val Thr Lys Thr Phe His Gly Ala Gly Leu Val Val
 225                 230                 235                 240
 Pro Val Asp Lys Asn Asp Val Gly Tyr Arg Glu Leu Pro Glu Thr Asp
                 245                 250                 255    
 Ala Asp Leu Lys Arg Ile Cys Lys Thr Ile Val Glu Ala Ala Ser Asp
             260                 265                 270        
 Glu Glu Arg Leu Lys Ala Phe Ala Pro Ile Gln Glu Met Met Thr Phe
         275                 280                 285            
 Val Gln Phe Ala Asn Asp Glu Cys Asp Tyr Gly Met Gly Leu Glu Leu
     290                 295                 300                
 Gly Met Asp Leu Phe Cys Tyr Gly Ser His Tyr Phe His Lys Val Ala
 305                 310                 315                 320
 Gly Gln Leu Leu Pro Leu Ala Tyr Asn Leu Leu Lys Arg Asn Leu Phe
                 325                 330                 335    
 Ala Glu Ile Ile Glu Glu His Leu Ala Asn Arg Ser Gln Glu Asn Ile
             340                 345                 350        
 Asp Gln Leu Ala Ala
         355        



      <210> 696
      <211> 284
      <212> PRT
      <213> Homo sapiens


      <400> 696
 His Glu Glu Arg Lys Met Ala Ala Pro Val Arg Arg Thr Leu Leu Gly
   1               5                  10                  15    
 Val Ala Gly Gly Trp Arg Arg Phe Glu Arg Leu Trp Ala Gly Ser Leu
              20                  25                  30        
 Ser Ser Arg Ser Leu Ala Leu Ala Ala Ala Pro Ser Ser Asn Gly Ser
          35                  40                  45            
 Pro Trp Arg Leu Leu Gly Ala Leu Cys Leu Gln Arg Pro Pro Val Val
      50                  55                  60                
 Ser Lys Pro Leu Thr Pro Leu Gln Glu Glu Met Ala Ser Leu Leu Gln
  65                  70                  75                  80
 Gln Ile Glu Ile Glu Arg Ser Leu Tyr Ser Asp His Glu Leu Arg Ala
                  85                  90                  95    
 Leu Asp Glu Asn Gln Arg Leu Ala Lys Lys Lys Ala Asp Leu His Asp
             100                 105                 110        
 Glu Glu Asp Glu Gln Asp Ile Leu Leu Ala Gln Asp Leu Glu Asp Met
         115                 120                 125            
 Trp Glu Gln Lys Phe Leu Gln Phe Lys Leu Gly Ala Arg Ile Thr Glu
     130                 135                 140                
 Ala Asp Glu Lys Asn Asp Arg Thr Ser Leu Asn Arg Lys Leu Asp Arg
 145                 150                 155                 160
 Asn Leu Val Leu Leu Val Arg Glu Lys Phe Gly Asp Gln Asp Val Trp
                 165                 170                 175    
 Ile Leu Pro Gln Ala Glu Trp Gln Pro Gly Glu Thr Leu Arg Gly Thr
             180                 185                 190        
 Ala Glu Arg Thr Leu Ala Thr Leu Ser Glu Asn Asn Met Glu Ala Lys
         195                 200                 205            
 Phe Leu Gly Asn Ala Pro Cys Gly His Tyr Thr Phe Lys Phe Pro Gln
     210                 215                 220                
 Ala Met Arg Thr Glu Ser Asn Leu Gly Ala Lys Val Phe Phe Phe Lys
 225                 230                 235                 240
 Ala Leu Leu Leu Thr Gly Asp Phe Ser Gln Ala Gly Asn Lys Gly His
                 245                 250                 255    
 His Val Trp Val Thr Lys Asp Glu Leu Gly Asp Tyr Leu Lys Pro Lys
             260                 265                 270        
 Tyr Leu Ala Gln Val Arg Arg Phe Val Ser Asp Leu
         275                 280                



      <210> 697
      <211> 104
      <212> PRT
      <213> Homo sapiens


      <400> 697
 Leu Ser Gly Ile Trp Ser Ser Leu Ala Gly Ile Trp His Glu Pro Leu
   1               5                  10                  15    
 Ser Trp Asp Ser Glu Ser Thr Met Pro Ser Ser Val Ser Trp Gly Ile
              20                  25                  30        
 Leu Leu Leu Ala Gly Leu Cys Cys Leu Val Pro Val Ser Leu Ala Glu
          35                  40                  45            
 Asp Pro Gln Gly Asp Ala Ala His Lys Thr Asp Thr Ser His Cys Ala
      50                  55                  60                
 Pro Ala Leu Ala Lys Phe Leu Tyr Phe Trp Thr Phe Asn Thr Ile Gly
  65                  70                  75                  80
 Phe His Pro Val His Cys Arg Pro Cys Phe Leu Arg Gln Ser Phe Ser
                  85                  90                  95    
 Leu Ser Pro Arg Leu Gly Val Gln
             100                



      <210> 698
      <211> 218
      <212> PRT
      <213> Homo sapiens


      <400> 698
 Ser Ser Ala Val Glu Phe Gly Val Ala Leu Gly Arg Asn Gln Pro Leu
   1               5                  10                  15    
 Lys Lys Glu Lys Pro Lys Trp Lys Ser Asp Tyr Pro Met Thr Asp Gly
              20                  25                  30        
 Gln Leu Arg Ser Lys Arg Asp Glu Phe Trp Asp Thr Ala Pro Ala Phe
          35                  40                  45            
 Glu Gly Arg Lys Glu Ile Trp Asp Ala Leu Lys Ala Ala Ala His Ala
      50                  55                  60                
 Phe Glu Ser Asn Asp His Glu Leu Ala Gln Ala Ile Ile Asp Gly Ala
  65                  70                  75                  80
 Asn Ile Thr Leu Pro His Gly Ala Leu Thr Glu Cys Tyr Asp Glu Leu
                  85                  90                  95    
 Gly Asn Arg Tyr Gln Leu Pro Val Tyr Cys Leu Ala Pro Pro Ile Asn
             100                 105                 110        
 Met Ile Glu Glu Lys Ser Asp Ile Glu Thr Leu Asp Ile Pro Glu Pro
         115                 120                 125            
 Pro Pro Asn Ser Gly Tyr Glu Cys Gln Leu Arg Leu Arg Leu Ser Thr
     130                 135                 140                
 Gly Lys Asp Leu Lys Leu Val Val Arg Ser Thr Asp Thr Val Phe His
 145                 150                 155                 160
 Met Lys Arg Arg Leu His Ala Ala Glu Gly Val Glu Pro Gly Ser Gln
                 165                 170                 175    
 Arg Trp Phe Phe Ser Gly Arg Pro Leu Thr Asp Lys Met Lys Phe Glu
             180                 185                 190        
 Glu Leu Lys Ile Pro Lys Asp Tyr Val Val Gln Val Ile Val Ser Gln
         195                 200                 205            
 Pro Val Gln Asn Pro Thr Pro Val Glu Asn
     210                 215            



      <210> 699
      <211> 207
      <212> PRT
      <213> Homo sapiens


      <400> 699
 Pro Ser Lys Glu Gly Asn Gly Pro Ala Ala Asp His Tyr Gln Pro Ala
   1               5                  10                  15    
 Ser Pro Pro Arg Asp Ala Cys Val Tyr Ser Ser Cys Tyr Cys Glu Glu
              20                  25                  30        
 Asn Ile Trp Lys Leu Cys Glu Tyr Ile Lys Asn His Asp Gln Tyr Pro
          35                  40                  45            
 Leu Lys Glu Cys Tyr Ala Val Phe Ile Ser Asn Glu Arg Lys Met Ile
      50                  55                  60                
 Pro Ile Trp Lys Gln Gln Ala Arg Pro Gly Asp Gly Pro Val Ile Arg
  65                  70                  75                  80
 Asp Tyr His Val Val Leu Leu His Val Ser Ser Gly Gly Leu Ser Phe
                  85                  90                  95    
 Ile Tyr Asp Leu Asp Thr Val Leu Pro Phe Pro Cys Leu Phe Asp Thr
             100                 105                 110        
 Tyr Val Glu Asp Ala Ile Lys Ser Asp Asp Asp Ile His Pro Gln Phe
         115                 120                 125            
 Arg Arg Lys Phe Arg Val Ile Cys Ala Asp Ser Tyr Leu Lys Asn Phe
     130                 135                 140                
 Ala Ser Asp Arg Ser His Met Lys Asp Ser Ser Gly Asn Trp Arg Glu
 145                 150                 155                 160
 Pro Pro Pro Pro Tyr Pro Cys Ile Glu Thr Gly Asp Ser Lys Met Asn
                 165                 170                 175    
 Leu Asn Asp Phe Ile Ser Met Asp Pro Lys Val Gly Trp Gly Ala Val
             180                 185                 190        
 Tyr Thr Leu Ser Glu Phe Thr His Arg Phe Gly Ser Lys Asn Cys
         195                 200                 205        



      <210> 700
      <211> 101
      <212> PRT
      <213> Homo sapiens


      <400> 700
 Asp Pro Thr Trp Leu Ser Ser Pro Gly Thr Ser Gln Gly Ala Thr Pro
   1               5                  10                  15    
 Ser Ser Ser Thr Leu Gly Gln Gln Ala Gly Thr His Gly Thr Leu Asp
              20                  25                  30        
 Pro Lys Trp Val Arg Gly Trp Val Ala Met Leu Ile Leu Gly Leu Leu
          35                  40                  45            
 Leu Leu Ala Leu Leu Leu Pro Val Gln Val Ser Ser Phe Val Pro Leu
      50                  55                  60                
 Thr Ser Met Pro Glu Ala Thr Ala Ala Glu Thr Thr Lys Pro Ser Asn
  65                  70                  75                  80
 Ser Ala Leu Gln Pro Thr Ala Gly Leu Leu Val Val Leu Leu Ala Leu
                  85                  90                  95    
 Leu His Leu Tyr His
             100    



      <210> 701
      <211> 257
      <212> PRT
      <213> Homo sapiens


      <400> 701
 Gly Asn Leu Glu Arg Gly Ser His Ser Leu Pro Ser Phe Leu Arg Val
   1               5                  10                  15    
 Cys Asp Ser Glu Met Asp Lys Val Cys Ala Val Phe Gly Gly Ser Arg
              20                  25                  30        
 Gly Ile Gly Arg Ala Val Ala Gln Leu Met Ala Arg Lys Gly Tyr Arg
          35                  40                  45            
 Leu Ala Val Ile Ala Arg Asn Leu Glu Gly Ala Lys Ala Ala Ala Gly
      50                  55                  60                
 Asp Leu Gly Gly Asp His Leu Ala Phe Ser Cys Asp Val Ala Lys Glu
  65                  70                  75                  80
 His Asp Val Gln Asn Thr Phe Glu Glu Met Glu Lys His Leu Gly Arg
                  85                  90                  95    
 Val Asn Phe Leu Val Asn Ala Ala Gly Ile Asn Arg Asp Gly Leu Leu
             100                 105                 110        
 Val Arg Thr Lys Thr Glu Asp Met Val Ser Gln Leu His Thr Asn Leu
         115                 120                 125            
 Leu Gly Ser Met Leu Thr Cys Lys Ala Ala Met Arg Thr Met Ile Gln
     130                 135                 140                
 Gln Gln Gly Gly Ser Ile Val Asn Val Gly Ser Ile Val Gly Leu Lys
 145                 150                 155                 160
 Gly Asn Ser Gly Gln Ser Val Tyr Ser Ala Ser Lys Gly Gly Leu Val
                 165                 170                 175    
 Gly Phe Ser Arg Ala Leu Ala Lys Glu Val Ala Arg Lys Lys Ile Arg
             180                 185                 190        
 Val Asn Val Val Ala Pro Gly Phe Val His Thr Asp Met Thr Lys Asp
         195                 200                 205            
 Leu Lys Glu Glu His Leu Lys Lys Asn Ile Pro Leu Gly Arg Phe Gly
     210                 215                 220                
 Glu Thr Ile Glu Val Ala His Ala Val Val Phe Leu Leu Glu Ser Pro
 225                 230                 235                 240
 Tyr Ile Thr Gly His Val Leu Val Val Asp Gly Gly Leu Gln Leu Ile
                 245                 250                 255    
 Leu
    



      <210> 702
      <211> 246
      <212> PRT
      <213> Homo sapiens


      <400> 702
 Arg Pro Ser Ser Ser Ile Val Ser Val Val Glu Phe Val Thr Arg Glu
   1               5                  10                  15    
 Val Leu Val Glu Thr Tyr Glu Glu Ser Val Pro Val Ser Ser Tyr Gln
              20                  25                  30        
 Gln Ala Gly Ile Pro Val Asp Leu Lys Arg Lys Ile Ala Arg Leu Gly
          35                  40                  45            
 Ile Asn Met Leu Leu Lys Met Ile Phe Val Asp Asn Phe Val His Ala
      50                  55                  60                
 Asp Leu His Pro Gly Asn Ile Leu Val Gln Gly Ala Asn Gly Leu Ser
  65                  70                  75                  80
 Ser Ser Gln Glu Ala Gln Leu Gln Gln Ala Asp Ile Cys Asp Thr Leu
                  85                  90                  95    
 Val Val Ala Val Pro Ser Ser Leu Cys Pro Leu Arg Leu Val Leu Leu
             100                 105                 110        
 Asp Ala Gly Ile Val Ala Glu Leu Gln Ala Pro Asp Leu Arg Asn Phe
         115                 120                 125            
 Arg Ala Val Phe Met Ala Val Val Met Gly Gln Gly Gln Arg Val Ala
     130                 135                 140                
 Glu Leu Ile Leu His His Ala Arg Ala Ser Glu Cys Arg Asp Val Glu
 145                 150                 155                 160
 Gly Phe Lys Thr Glu Met Ala Met Leu Val Thr Gln Ala Arg Lys Asn
                 165                 170                 175    
 Thr Ile Thr Leu Glu Lys Leu His Val Ser Ser Leu Leu Ser Ser Val
             180                 185                 190        
 Phe Lys Leu Leu Met Thr His Lys Val Lys Leu Glu Ser Asn Phe Ala
         195                 200                 205            
 Ser Ile Val Phe Ala Ile Met Val Leu Glu Gly Leu Gly Arg Ser Leu
     210                 215                 220                
 Asp Pro Lys Leu Asp Ile Leu Glu Ala Ala Arg Pro Phe Leu Leu Thr
 225                 230                 235                 240
 Gly Pro Val Cys Pro Pro
                 245    



      <210> 703
      <211> 291
      <212> PRT
      <213> Homo sapiens


      <400> 703
 His Gln Lys Gln Val Arg Met Thr Thr Leu Thr His Arg Ala Arg Arg
   1               5                  10                  15    
 Thr Glu Ile Ser Lys Asn Ser Glu Lys Lys Met Glu Ser Glu Glu Asp
              20                  25                  30        
 Ser Asn Trp Glu Lys Ser Pro Asp Asn Glu Asp Ser Gly Asp Ser Lys
          35                  40                  45            
 Asp Ile Arg Leu Thr Leu Met Glu Glu Val Leu Leu Leu Gly Leu Lys
      50                  55                  60                
 Asp Lys Glu Gly Tyr Thr Ser Phe Trp Asn Asp Cys Ile Ser Ser Gly
  65                  70                  75                  80
 Leu Arg Gly Gly Ile Leu Ile Glu Leu Ala Met Arg Gly Arg Ile Tyr
                  85                  90                  95    
 Leu Glu Pro Pro Thr Met Arg Lys Lys Arg Leu Leu Asp Arg Lys Val
             100                 105                 110        
 Leu Leu Lys Ser Asp Ser Pro Thr Gly Asp Val Leu Leu Asp Glu Thr
         115                 120                 125            
 Leu Lys His Ile Lys Ala Thr Glu Pro Thr Glu Thr Val Gln Thr Trp
     130                 135                 140                
 Ile Glu Leu Leu Thr Gly Glu Thr Trp Asn Pro Phe Lys Leu Gln Tyr
 145                 150                 155                 160
 Gln Leu Arg Asn Val Arg Glu Arg Ile Ala Lys Asn Leu Val Glu Lys
                 165                 170                 175    
 Gly Ile Leu Thr Thr Glu Lys Gln Asn Phe Leu Leu Phe Asp Met Thr
             180                 185                 190        
 Thr His Pro Val Thr Asn Thr Thr Glu Lys Gln Arg Leu Val Lys Lys
         195                 200                 205            
 Leu Gln Asp Ser Val Leu Glu Arg Trp Val Asn Asp Pro Gln Arg Met
     210                 215                 220                
 Asp Lys Arg Thr Leu Ala Leu Leu Val Leu Ala His Ser Ser Asp Val
 225                 230                 235                 240
 Leu Glu Asn Val Phe Ser Ser Leu Thr Asp Asp Lys Tyr Asp Val Ala
                 245                 250                 255    
 Met Asn Arg Ala Lys Asp Leu Val Glu Leu Asp Pro Glu Val Glu Gly
             260                 265                 270        
 Thr Lys Pro Ser Ala Thr Glu Met Ile Trp Ala Val Leu Ala Ala Phe
         275                 280                 285            
 Asn Lys Ser
     290    



      <210> 704
      <211> 433
      <212> PRT
      <213> Homo sapiens


      <400> 704
 Ile Ala Thr Lys Ala Met Ser Tyr Tyr Leu Ser Ser Glu Asn His Leu
   1               5                  10                  15    
 Asp Pro Gly Pro Ile Tyr Met Arg Glu Asn Gly Gln Leu His Met Val
              20                  25                  30        
 Asn Leu Ala Leu Asp Gly Val Arg Ser Ser Leu Gln Lys Pro Arg Pro
          35                  40                  45            
 Phe Arg Leu Phe Pro Lys Gly Phe Ser Val Glu Leu Cys Met Asn Arg
      50                  55                  60                
 Glu Asp Asp Thr Ala Arg Lys Glu Lys Thr Asp His Phe Ile Phe Thr
  65                  70                  75                  80
 Tyr Thr Arg Glu Gly Asn Leu Arg Tyr Ser Ala Lys Ser Leu Phe Ser
                  85                  90                  95    
 Leu Val Leu Gly Phe Ile Ser Asp Asn Val Asp His Ile Asp Ser Leu
             100                 105                 110        
 Ile Gly Phe Pro Glu Gln Ile Ala Glu Lys Leu Phe Ser Ala Ala Glu
         115                 120                 125            
 Ala Arg Gln Lys Phe Thr Glu Pro Gly Ala Gly Leu Arg Ala Leu Gln
     130                 135                 140                
 Lys Phe Thr Glu Ala Tyr Gly Ser Leu Val Leu Cys Ser Leu Cys Leu
 145                 150                 155                 160
 Arg Asn Arg Tyr Leu Val Ile Ser Glu Lys Leu Glu Glu Ile Lys Ser
                 165                 170                 175    
 Phe Arg Glu Leu Thr Cys Leu Asp Leu Ser Cys Cys Lys Leu Gly Asp
             180                 185                 190        
 Glu His Glu Leu Leu Glu His Leu Thr Asn Glu Ala Leu Ser Ser Val
         195                 200                 205            
 Thr Gln Leu His Leu Lys Asp Asn Cys Leu Ser Asp Ala Gly Val Arg
     210                 215                 220                
 Lys Met Thr Ala Pro Val Arg Val Met Lys Arg Gly Leu Glu Asn Leu
 225                 230                 235                 240
 Thr Leu Leu Asp Leu Ser Cys Asn Pro Asp Ile Thr Asp Ala Gly Ile
                 245                 250                 255    
 Gly Tyr Leu Phe Ser Phe Arg Lys Leu Asn Cys Leu Asp Ile Ser Gly
             260                 265                 270        
 Thr Gly Leu Lys Asp Ile Lys Thr Val Lys His Lys Leu Gln Thr His
         275                 280                 285            
 Ile Gly Leu Val His Ser Lys Val Pro Leu Lys Glu Phe Asp His Ser
     290                 295                 300                
 Asn Cys Lys Thr Glu Gly Trp Ala Asp Gln Ile Val Leu Gln Trp Glu
 305                 310                 315                 320
 Arg Val Thr Ala Glu Ala Val Lys Pro Arg Glu Thr Ser Glu Pro Arg
                 325                 330                 335    
 Ala Ala Ala Gln Arg Phe Tyr Gly Lys Arg Ser Arg Ala Glu Ala Pro
             340                 345                 350        
 Leu Lys Cys Pro Leu Ala Asp Thr His Met Asn Ser Ser Glu Lys Leu
         355                 360                 365            
 Gln Phe Tyr Lys Glu Lys Ala Pro Asp Cys His Gly Pro Val Leu Lys
     370                 375                 380                
 His Glu Ala Ile Ser Ser Gln Glu Ser Lys Lys Ser Lys Lys Arg Pro
 385                 390                 395                 400
 Phe Glu Glu Ser Glu Thr Glu Gln Asn Asn Ser Ser Gln Pro Ser Lys
                 405                 410                 415    
 Gln Lys Tyr Val Cys Leu Ala Val Glu Asp Trp Asp Leu Leu Asn Ser
             420                 425                 430        
 Tyr
    



      <210> 705
      <211> 115
      <212> PRT
      <213> Homo sapiens


      <400> 705
 Gly Ser Val Asp Val Thr Ala Met Ala Ala Pro Cys Leu Leu Arg Gln
   1               5                  10                  15    
 Gly Arg Ala Gly Ala Leu Lys Thr Met Leu Gln Glu Ala Gln Val Phe
              20                  25                  30        
 Arg Gly Leu Ala Ser Thr Val Ser Leu Ser Ala Glu Ser Gly Lys Ser
          35                  40                  45            
 Glu Lys Gly Gln Pro Gln Asn Ser Lys Lys Gln Ser Pro Pro Lys Lys
      50                  55                  60                
 Pro Ala Pro Val Pro Ala Glu Pro Phe Asp Asn Thr Thr Tyr Lys Asn
  65                  70                  75                  80
 Leu Gln His His Asp Tyr Ser Thr Tyr Thr Phe Leu Asp Leu Asn Leu
                  85                  90                  95    
 Glu Leu Ser Lys Phe Arg Met Pro Gln Pro Ser Ser Gly Arg Glu Ser
             100                 105                 110        
 Pro Arg His
         115



      <210> 706
      <211> 115
      <212> PRT
      <213> Homo sapiens


      <400> 706
 Gly Ser Val Asp Val Thr Ala Met Ala Ala Pro Cys Leu Leu Arg Gln
   1               5                  10                  15    
 Gly Arg Ala Gly Ala Leu Lys Thr Met Leu Gln Glu Ala Gln Val Phe
              20                  25                  30        
 Arg Gly Leu Ala Ser Thr Val Ser Leu Ser Ala Glu Ser Gly Lys Ser
          35                  40                  45            
 Glu Lys Gly Gln Pro Gln Asn Ser Lys Lys Gln Ser Pro Pro Lys Lys
      50                  55                  60                
 Pro Ala Pro Val Pro Ala Glu Pro Phe Asp Asn Thr Thr Tyr Lys Asn
  65                  70                  75                  80
 Leu Gln His His Asp Tyr Ser Thr Tyr Thr Phe Leu Asp Leu Asn Leu
                  85                  90                  95    
 Glu Leu Ser Lys Phe Arg Met Pro Gln Pro Ser Ser Gly Arg Glu Ser
             100                 105                 110        
 Pro Arg His
         115



      <210> 707
      <211> 44
      <212> PRT
      <213> Homo sapiens


      <400> 707
 Lys Leu Arg Arg Val Lys Met Lys Val Arg Ala Ser Val Lys Lys Leu
   1               5                  10                  15    
 Cys Arg Asn Cys Lys Ile Val Lys Arg Asp Gly Gly Ile Arg Val Ile
              20                  25                  30        
 Cys Ser Ala Glu Pro Lys His Lys Gln Arg Gln Gly
          35                  40                



      <210> 708
      <211> 151
      <212> PRT
      <213> Homo sapiens


      <400> 708
 Ala Ile Thr Tyr Trp Ser Pro Arg Leu Arg Cys Cys Ala Gly Ser Ser
   1               5                  10                  15    
 Leu Ala Asn Ile Trp Arg Leu Trp Ala Lys Gln Asp Glu Arg Asp Leu
              20                  25                  30        
 Tyr Gly Glu Val Glu Arg Arg Lys Ser Leu Gly Gly Gly Gly Glu Pro
          35                  40                  45            
 Lys Gly Glu Leu Arg Gly His Ser Asp Asp Arg His Ala Pro Ser Pro
      50                  55                  60                
 Leu Pro Ala Arg Ala Gly Trp Leu Lys Lys Ile Leu Asn Gly Pro Asn
  65                  70                  75                  80
 Gly Gln Leu Glu Arg Ala Met Asp Asp Ile Leu Val Thr Ser Asp Leu
                  85                  90                  95    
 Thr Ser Arg Tyr Lys Ile Ser Arg Lys Thr Leu Trp Ser Trp Gln Ser
             100                 105                 110        
 Ala Asp Thr Met Pro Arg Gly Phe Val Cys Pro Phe Pro Pro Pro Asp
         115                 120                 125            
 Trp Pro Gly Asn Pro Asn Arg Trp Arg Ser Glu Ser Ile Lys Glu Trp
     130                 135                 140                
 Glu Asp Lys Lys Lys Ile Asn
 145                 150    



      <210> 709
      <211> 221
      <212> PRT
      <213> Homo sapiens


      <400> 709
 Gly Gly Ile Arg Pro Ser Gly Arg Pro Arg Gly Ala Arg Ala Gly Leu
   1               5                  10                  15    
 Pro Ala Gly Asp Ser Thr Gly Ala Leu Pro Ile Pro Phe Val Ser Leu
              20                  25                  30        
 Leu Ser Pro Ala Ser Pro Trp Ile Met Phe Lys Lys Phe Asp Glu Lys
          35                  40                  45            
 Glu Ser Val Ser Asn Cys Ile Gln Leu Lys Thr Ser Val Ile Lys Gly
      50                  55                  60                
 Ile Lys Ser Gln Leu Val Glu Gln Phe Pro Gly Ile Glu Pro Trp Leu
  65                  70                  75                  80
 Asn Gln Ile Met Pro Lys Lys Asp Pro Val Lys Ile Val Arg Cys His
                  85                  90                  95    
 Glu His Thr Glu Ile Leu Thr Val Ser Gly Glu Leu Leu Phe Phe Arg
             100                 105                 110        
 Gln Arg Lys Gly Pro Phe Cys Pro Thr Leu Arg Leu Leu His Lys Tyr
         115                 120                 125            
 Pro Phe Ile Leu Pro His Gln Gln Val Asp Lys Gly Ala Ile Lys Phe
     130                 135                 140                
 Val Leu Ser Gly Ala Asn Ile Met Cys Pro Gly Leu Thr Ser Pro Gly
 145                 150                 155                 160
 Ala Lys Leu Tyr Pro Ala Ala Val Asp Thr Ile Val Ala Val Thr Ala
                 165                 170                 175    
 Glu Gly Lys Gln His Ala Leu Cys Val Gly Val Met Lys Met Ser Ala
             180                 185                 190        
 Glu Asp Ile Glu Lys Val Asn Lys Gly Ile Gly Ile Glu Asn Ile His
         195                 200                 205            
 Tyr Leu Asn Asp Gly Leu Trp His Met Lys Thr Tyr Lys
     210                 215                 220    



      <210> 710
      <211> 300
      <212> PRT
      <213> Homo sapiens


      <400> 710
 Val Ala Pro Ser Lys Ala Arg Met Ser Pro Ala His Arg Asp Tyr Thr
   1               5                  10                  15    
 Ala Gly Ala Val Ser Tyr Asp Asp Thr Leu Glu Asp Pro Ala Pro Met
              20                  25                  30        
 Thr Pro Pro Pro Ser Asp Met Gly Ser Val Pro Trp Lys Pro Val Ile
          35                  40                  45            
 Pro Glu Arg Lys Tyr Gln His Leu Ala Lys Cys Gly Gly Arg Arg Gly
      50                  55                  60                
 Gln Ser Thr Leu Pro Cys His Asp Pro Val Ile Lys Pro Phe Asp Ser
  65                  70                  75                  80
 Val Asp Lys Ala Pro Lys Trp Val Lys Ala Lys Ala Thr His Val Ile
                  85                  90                  95    
 Met Asn Ser Leu Ile Thr Lys Gln Thr Gln Glu Ser Ile Gln His Phe
             100                 105                 110        
 Glu Arg Gln Ala Gly Leu Arg Asp Ala Gly Tyr Thr Pro His Lys Gly
         115                 120                 125            
 Leu Thr Thr Arg Gly Asp Gln Val Pro Phe Glu Leu Ala Glu Ala Leu
     130                 135                 140                
 His Lys Leu Lys Leu Gln Ser Gly Glu Val Asn Lys Arg Arg Arg Gly
 145                 150                 155                 160
 Ser Leu His Gln Pro Ser Pro Pro Gln Ala Pro Leu Arg Thr Pro Leu
                 165                 170                 175    
 Pro Lys Gln Arg Pro Arg Gly Trp Phe Thr Ser Gly Ser Ser Thr Gly
             180                 185                 190        
 Leu Pro Gly Pro Asn Pro Ser Ile Met Asp Ser Gly Ser Trp Gly Ile
         195                 200                 205            
 Lys Asp Lys Lys Leu Cys Ser Asp Lys Trp Ser Leu Phe Gly Pro Arg
     210                 215                 220                
 Ser Leu Gln Lys Tyr Asp Ser Gly Ser Phe Ala Thr Gln Ala Tyr Arg
 225                 230                 235                 240
 Gly Ala Gln Lys Pro Ser Pro Leu Glu Leu Ile Arg Ala Gln Ala Asn
                 245                 250                 255    
 Arg Met Ala Glu Asp Pro Ala Ala Leu Lys Pro Pro Lys Met Asp Ile
             260                 265                 270        
 Pro Val Met Glu Gly Lys Lys Gln Pro Pro Arg Ala His Asn Leu Lys
         275                 280                 285            
 Pro Arg Asp Leu Asn Val Leu Thr Pro Thr Gly Phe
     290                 295                 300



      <210> 711
      <211> 1596
      <212> PRT
      <213> Homo sapiens


      <400> 711
 Leu Arg Tyr Arg Ser Gly Ile Ser Gly Ser Thr Ile Ser Cys Cys Ile
   1               5                  10                  15    
 Gly Gln Arg Lys Leu Cys Asn Gly Val Asn Asp Cys Gly Asp Asn Ser
              20                  25                  30        
 Asp Glu Ser Pro Gln Gln Asn Cys Arg Pro Arg Thr Gly Glu Glu Asn
          35                  40                  45            
 Cys Asn Val Asn Asn Gly Gly Cys Ala Gln Lys Cys Gln Met Val Arg
      50                  55                  60                
 Gly Ala Val Gln Cys Thr Cys His Thr Gly Tyr Arg Leu Thr Glu Asp
  65                  70                  75                  80
 Gly His Thr Cys Gln Asp Val Asn Glu Cys Ala Glu Glu Gly Tyr Cys
                  85                  90                  95    
 Ser Gln Gly Cys Thr Asn Ser Glu Gly Ala Phe Gln Cys Trp Cys Glu
             100                 105                 110        
 Thr Gly Tyr Glu Leu Arg Pro Asp Arg Arg Ser Cys Lys Ala Leu Gly
         115                 120                 125            
 Pro Glu Pro Val Leu Leu Phe Ala Asn Arg Ile Asp Ile Arg Gln Val
     130                 135                 140                
 Leu Pro His Arg Ser Glu Tyr Thr Leu Leu Leu Asn Asn Leu Glu Asn
 145                 150                 155                 160
 Ala Ile Ala Leu Asp Phe His His Arg Arg Glu Leu Val Phe Trp Ser
                 165                 170                 175    
 Asp Val Thr Leu Asp Arg Ile Leu Arg Ala Asn Leu Asn Gly Ser Asn
             180                 185                 190        
 Val Glu Glu Val Val Ser Thr Gly Leu Glu Ser Pro Gly Gly Leu Ala
         195                 200                 205            
 Val Asp Trp Val His Asp Lys Leu Tyr Trp Thr Asp Ser Gly Thr Ser
     210                 215                 220                
 Arg Ile Glu Val Ala Asn Leu Asp Gly Ala His Arg Lys Val Leu Leu
 225                 230                 235                 240
 Trp Gln Asn Leu Glu Lys Pro Arg Ala Ile Ala Leu His Pro Met Glu
                 245                 250                 255    
 Gly Thr Ile Tyr Trp Thr Asp Trp Gly Asn Thr Pro Arg Ile Glu Ala
             260                 265                 270        
 Ser Ser Met Asp Gly Ser Gly Arg Arg Ile Ile Ala Asp Thr His Leu
         275                 280                 285            
 Phe Trp Pro Asn Gly Leu Thr Ile Asp Tyr Ala Gly Arg Arg Met Tyr
     290                 295                 300                
 Trp Val Asp Ala Lys His His Val Ile Glu Arg Ala Asn Leu Asp Gly
 305                 310                 315                 320
 Ser His Arg Lys Ala Val Ile Ser Gln Gly Leu Pro His Pro Phe Ala
                 325                 330                 335    
 Ile Thr Val Phe Glu Asp Ser Leu Tyr Trp Thr Asp Trp His Thr Lys
             340                 345                 350        
 Ser Ile Asn Ser Ala Asn Lys Phe Thr Gly Lys Asn Gln Glu Ile Ile
         355                 360                 365            
 Arg Asn Lys Leu His Phe Pro Met Asp Ile His Thr Leu His Pro Gln
     370                 375                 380                
 Arg Gln Pro Ala Gly Lys Asn Arg Cys Gly Asp Asn Asn Gly Gly Cys
 385                 390                 395                 400
 Thr His Leu Cys Leu Pro Ser Gly Gln Asn Tyr Thr Cys Ala Cys Pro
                 405                 410                 415    
 Thr Gly Phe Arg Lys Ile Ser Ser His Ala Cys Ala Gln Ser Leu Asp
             420                 425                 430        
 Lys Phe Leu Leu Phe Ala Arg Arg Met Asp Ile Arg Arg Ile Ser Phe
         435                 440                 445            
 Asp Thr Glu Asp Leu Ser Asp Asp Val Ile Pro Leu Ala Asp Val Arg
     450                 455                 460                
 Ser Ala Val Ala Leu Asp Trp Asp Ser Arg Asp Asp His Val Tyr Trp
 465                 470                 475                 480
 Thr Asp Val Ser Thr Asp Thr Ile Ser Arg Ala Lys Trp Asp Gly Thr
                 485                 490                 495    
 Gly Gln Glu Val Val Val Asp Thr Ser Leu Glu Ser Pro Ala Gly Leu
             500                 505                 510        
 Ala Ile Asp Trp Val Thr Asn Lys Leu Tyr Trp Thr Asp Ala Gly Thr
         515                 520                 525            
 Asp Arg Ile Glu Val Ala Asn Thr Asp Gly Ser Met Arg Thr Val Leu
     530                 535                 540                
 Ile Trp Glu Asn Leu Asp Arg Pro Arg Asp Ile Val Val Glu Pro Met
 545                 550                 555                 560
 Gly Gly Tyr Met Tyr Trp Thr Asp Trp Gly Ala Ser Pro Lys Ile Glu
                 565                 570                 575    
 Arg Ala Gly Met Asp Ala Ser Gly Arg Gln Val Ile Ile Ser Ser Asn
             580                 585                 590        
 Leu Thr Trp Pro Asn Gly Leu Ala Ile Asp Tyr Gly Ser Gln Arg Leu
         595                 600                 605            
 Tyr Trp Ala Asp Ala Gly Met Lys Thr Ile Glu Phe Ala Gly Leu Asp
     610                 615                 620                
 Gly Ser Lys Arg Lys Val Leu Ile Gly Ser Gln Leu Pro His Pro Phe
 625                 630                 635                 640
 Gly Leu Thr Leu Tyr Gly Glu Arg Ile Tyr Trp Thr Asp Trp Gln Thr
                 645                 650                 655    
 Lys Ser Ile Gln Ser Ala Asp Arg Leu Thr Gly Leu Asp Arg Glu Thr
             660                 665                 670        
 Leu Gln Glu Asn Leu Glu Asn Leu Met Asp Ile His Val Phe His Arg
         675                 680                 685            
 Arg Arg Pro Pro Val Ser Thr Pro Cys Ala Met Glu Asn Gly Gly Cys
     690                 695                 700                
 Ser His Leu Cys Leu Arg Ser Pro Asn Pro Ser Gly Phe Ser Cys Thr
 705                 710                 715                 720
 Cys Pro Thr Gly Ile Asn Leu Leu Ser Asp Gly Lys Thr Cys Ser Pro
                 725                 730                 735    
 Gly Met Asn Ser Phe Leu Ile Phe Ala Arg Arg Ile Asp Ile Arg Met
             740                 745                 750        
 Val Ser Leu Asp Ile Pro Tyr Phe Ala Asp Val Val Val Pro Ile Asn
         755                 760                 765            
 Ile Thr Met Lys Asn Thr Ile Ala Val Gly Val Asp Pro Gln Glu Gly
     770                 775                 780                
 Lys Val Tyr Trp Ser Asp Ser Thr Leu His Arg Ile Ser Arg Ala Asn
 785                 790                 795                 800
 Leu Asp Gly Ser Gln His Glu Asp Ile Ile Thr Thr Gly Leu Gln Thr
                 805                 810                 815    
 Thr Asp Gly Leu Ala Val Asp Ala Ile Gly Arg Lys Val Tyr Trp Thr
             820                 825                 830        
 Asp Thr Gly Thr Asn Arg Ile Glu Val Gly Asn Leu Asp Gly Ser Met
         835                 840                 845            
 Arg Lys Val Leu Val Trp Gln Asn Leu Asp Ser Pro Arg Ala Ile Val
     850                 855                 860                
 Leu Tyr His Glu Met Gly Phe Met Tyr Trp Thr Asp Trp Gly Glu Asn
 865                 870                 875                 880
 Ala Lys Leu Glu Arg Ser Gly Met Asp Gly Ser Asp Arg Ala Val Leu
                 885                 890                 895    
 Ile Asn Asn Asn Leu Gly Trp Pro Asn Gly Leu Thr Val Asp Lys Ala
             900                 905                 910        
 Ser Ser Gln Leu Leu Trp Ala Asp Ala His Thr Glu Arg Ile Glu Ala
         915                 920                 925            
 Ala Asp Leu Asn Gly Ala Asn Arg His Thr Leu Val Ser Pro Val Gln
     930                 935                 940                
 His Pro Tyr Gly Leu Thr Leu Leu Asp Ser Tyr Ile Tyr Trp Thr Asp
 945                 950                 955                 960
 Trp Gln Thr Arg Ser Ile His Arg Ala Asp Lys Gly Thr Gly Ser Asn
                 965                 970                 975    
 Val Ile Leu Val Arg Ser Asn Leu Pro Gly Leu Met Asp Met Gln Ala
             980                 985                 990        
 Val Asp Arg Ala Gln Pro Leu Gly Phe Asn Lys Cys Gly Ser Arg Asn
         995                1000                1005            
 Gly Gly Cys Ser His Leu Cys Leu Pro Arg Pro Ser Gly Phe Ser Cys
    1010                1015                1020                
 Ala Cys Pro Thr Gly Ile Gln Leu Lys Gly Asp Gly Lys Thr Cys Asp
1025                1030                1035                1040
 Pro Ser Pro Glu Thr Tyr Leu Leu Phe Ser Ser Arg Gly Ser Ile Arg
                1045                1050                1055    
 Arg Ile Ser Leu Asp Thr Ser Asp His Thr Asp Val His Val Pro Val
            1060                1065                1070        
 Pro Glu Leu Asn Asn Val Ile Ser Leu Asp Tyr Asp Ser Val Asp Gly
        1075                1080                1085            
 Lys Val Tyr Tyr Thr Asp Val Phe Leu Asp Val Ile Arg Arg Ala Asp
    1090                1095                1100                
 Leu Asn Gly Ser Asn Met Glu Thr Val Ile Gly Arg Gly Leu Lys Thr
1105                1110                1115                1120
 Thr Asp Gly Leu Ala Val Asp Trp Val Ala Arg Asn Leu Tyr Trp Thr
                1125                1130                1135    
 Asp Thr Gly Arg Asn Thr Ile Glu Ala Ser Arg Leu Asp Gly Ser Cys
            1140                1145                1150        
 Arg Lys Val Leu Ile Asn Asn Ser Leu Asp Glu Pro Arg Ala Ile Ala
        1155                1160                1165            
 Val Phe Pro Arg Lys Gly Tyr Leu Phe Trp Thr Asp Trp Gly His Ile
    1170                1175                1180                
 Ala Lys Ile Glu Arg Ala Asn Leu Asp Gly Ser Glu Arg Lys Val Leu
1185                1190                1195                1200
 Ile Asn Thr Asp Leu Gly Trp Pro Asn Gly Leu Thr Leu Asp Tyr Asp
                1205                1210                1215    
 Thr Arg Arg Ile Tyr Trp Val Asp Ala His Leu Asp Arg Ile Glu Ser
            1220                1225                1230        
 Ala Asp Leu Asn Gly Lys Leu Arg Gln Val Leu Val Gly His Val Ser
        1235                1240                1245            
 His Pro Phe Ala Leu Thr Gln Gln Asp Arg Trp Ile Tyr Trp Thr Asp
    1250                1255                1260                
 Trp Gln Thr Lys Ser Ile Gln Arg Val Asp Lys Tyr Ser Gly Arg Asn
1265                1270                1275                1280
 Lys Glu Thr Val Leu Ala Asn Val Glu Gly Leu Met Asp Ile Ile Val
                1285                1290                1295    
 Val Ser Pro Gln Arg Gln Thr Gly Thr Asn Ala Cys Gly Val Asn Asn
            1300                1305                1310        
 Gly Gly Cys Thr His Leu Cys Phe Ala Arg Ala Ser Asp Phe Val Cys
        1315                1320                1325            
 Ala Cys Pro Asp Glu Pro Asp Ser Gln Pro Cys Ser Leu Val Pro Gly
    1330                1335                1340                
 Leu Val Pro Pro Ala Pro Arg Ala Thr Gly Met Ser Glu Lys Ser Pro
1345                1350                1355                1360
 Val Leu Pro Asn Thr Pro Pro Thr Thr Leu Tyr Ser Ser Thr Thr Arg
                1365                1370                1375    
 Thr Arg Thr Ser Leu Glu Glu Val Glu Gly Arg Cys Ser Glu Arg Asp
            1380                1385                1390        
 Ala Arg Leu Gly Leu Cys Ala Arg Ser Asn Asp Ala Val Pro Ala Ala
        1395                1400                1405            
 Pro Gly Glu Gly Leu His Ile Ser Tyr Ala Ile Gly Gly Leu Leu Ser
    1410                1415                1420                
 Ile Leu Leu Ile Leu Val Val Ile Ala Ala Leu Met Leu Tyr Arg His
1425                1430                1435                1440
 Lys Lys Ser Lys Phe Thr Asp Pro Gly Met Gly Asn Leu Thr Tyr Ser
                1445                1450                1455    
 Asn Pro Ser Tyr Arg Thr Ser Thr Gln Glu Val Lys Ile Glu Ala Ile
            1460                1465                1470        
 Pro Lys Pro Ala Met Tyr Asn Gln Leu Cys Tyr Lys Lys Glu Gly Gly
        1475                1480                1485            
 Pro Asp His Asn Tyr Thr Lys Glu Lys Ile Lys Ile Val Glu Gly Ile
    1490                1495                1500                
 Cys Leu Leu Ser Gly Asp Asp Ala Glu Trp Asp Asp Leu Lys Gln Leu
1505                1510                1515                1520
 Arg Ser Ser Arg Gly Gly Leu Leu Arg Asp His Val Cys Met Lys Thr
                1525                1530                1535    
 Asp Thr Val Ser Ile Gln Ala Ser Ser Gly Ser Leu Asp Asp Thr Glu
            1540                1545                1550        
 Met Glu Gln Leu Leu Gln Glu Glu Gln Ser Glu Cys Ser Ser Val His
        1555                1560                1565            
 Thr Ala Ala Thr Pro Glu Arg Arg Gly Ser Leu Pro Asp Thr Gly Trp
    1570                1575                1580                
 Lys His Glu Arg Lys Leu Ser Ser Glu Ser Gln Val
1585                1590                1595    



      <210> 712
      <211> 657
      <212> PRT
      <213> Homo sapiens


      <400> 712
 Arg Gln Arg Gly Gly Glu Lys Met Ala Thr Ser Asn Asn Pro Arg Lys
   1               5                  10                  15    
 Phe Ser Glu Lys Ile Ala Leu His Asn Gln Lys Gln Ala Glu Glu Thr
              20                  25                  30        
 Ala Ala Phe Glu Glu Val Met Lys Asp Leu Ser Leu Thr Arg Ala Ala
          35                  40                  45            
 Arg Leu Gln Leu Gln Lys Ser Gln Tyr Leu Gln Leu Gly Pro Ser Arg
      50                  55                  60                
 Gly Gln Tyr Tyr Gly Gly Ser Leu Pro Asn Val Asn Gln Ile Gly Ser
  65                  70                  75                  80
 Gly Thr Met Asp Leu Pro Phe Gln Pro Ser Gly Phe Leu Gly Glu Ala
                  85                  90                  95    
 Leu Ala Ala Ala Pro Val Ser Leu Thr Pro Phe Gln Ser Ser Gly Leu
             100                 105                 110        
 Asp Thr Ser Arg Thr Thr Arg His His Gly Leu Val Asp Arg Val Tyr
         115                 120                 125            
 Arg Glu Arg Gly Arg Leu Gly Ser Pro His Arg Arg Pro Leu Ser Val
     130                 135                 140                
 Asp Lys His Gly Arg Gln Ala Asp Ser Cys Pro Tyr Gly Thr Met Tyr
 145                 150                 155                 160
 Leu Ser Pro Pro Ala Asp Thr Ser Trp Arg Arg Thr Asn Ser Asp Ser
                 165                 170                 175    
 Ala Leu His Gln Ser Thr Met Thr Pro Thr Gln Pro Glu Ser Phe Ser
             180                 185                 190        
 Ser Gly Ser Gln Asp Val His Gln Lys Arg Val Leu Leu Leu Thr Val
         195                 200                 205            
 Pro Gly Met Glu Glu Thr Thr Ser Glu Ala Asp Lys Asn Leu Ser Lys
     210                 215                 220                
 Gln Ala Trp Asp Thr Lys Lys Thr Gly Ser Arg Pro Lys Ser Cys Glu
 225                 230                 235                 240
 Val Pro Gly Ile Asn Ile Phe Pro Ser Ala Asp Gln Glu Asn Thr Thr
                 245                 250                 255    
 Ala Leu Ile Pro Ala Thr His Asn Thr Gly Gly Ser Leu Pro Asp Leu
             260                 265                 270        
 Thr Asn Ile His Phe Pro Ser Pro Leu Pro Thr Pro Leu Asp Pro Glu
         275                 280                 285            
 Glu Pro Thr Phe Pro Ala Leu Ser Ser Ser Ser Ser Thr Gly Asn Leu
     290                 295                 300                
 Ala Ala Asn Leu Thr His Leu Gly Ile Gly Gly Ala Gly Gln Gly Met
 305                 310                 315                 320
 Ser Thr Pro Gly Ser Ser Pro Gln His Arg Pro Ala Gly Val Ser Pro
                 325                 330                 335    
 Leu Ser Leu Ser Thr Glu Ala Arg Arg Gln Gln Ala Ser Pro Thr Leu
             340                 345                 350        
 Ser Pro Leu Ser Pro Ile Thr Gln Ala Val Ala Met Asp Ala Leu Ser
         355                 360                 365            
 Leu Glu Gln Gln Leu Pro Tyr Ala Phe Phe Thr Gln Ala Gly Ser Gln
     370                 375                 380                
 Gln Pro Pro Pro Gln Pro Gln Pro Pro Pro Pro Pro Pro Pro Ala Ser
 385                 390                 395                 400
 Gln Gln Pro Pro Pro Pro Pro Pro Pro Gln Ala Pro Val Arg Leu Pro
                 405                 410                 415    
 Pro Gly Gly Pro Leu Leu Pro Ser Ala Ser Leu Thr Arg Gly Pro Gln
             420                 425                 430        
 Pro Pro Pro Leu Ala Val Thr Val Pro Ser Ser Leu Pro Gln Ser Pro
         435                 440                 445            
 Pro Glu Asn Pro Gly Gln Pro Ser Met Gly Ile Asp Ile Ala Ser Ala
     450                 455                 460                
 Pro Ala Leu Gln Gln Tyr Arg Thr Ser Ala Gly Ser Pro Ala Asn Gln
 465                 470                 475                 480
 Ser Pro Thr Ser Pro Val Ser Asn Gln Gly Phe Ser Pro Gly Ser Ser
                 485                 490                 495    
 Pro Gln His Thr Ser Thr Leu Gly Ser Val Phe Gly Asp Ala Tyr Tyr
             500                 505                 510        
 Glu Gln Gln Met Ala Ala Arg Gln Ala Asn Ala Leu Ser His Gln Leu
         515                 520                 525            
 Glu Gln Phe Asn Met Met Glu Asn Ala Ile Ser Ser Ser Ser Leu Tyr
     530                 535                 540                
 Ser Pro Gly Ser Thr Leu Asn Tyr Ser Gln Ala Ala Met Met Gly Leu
 545                 550                 555                 560
 Thr Gly Ser His Gly Ser Leu Pro Asp Ser Gln Gln Leu Gly Tyr Ala
                 565                 570                 575    
 Ser His Ser Gly Ile Pro Asn Ile Ile Leu Thr Val Thr Gly Glu Ser
             580                 585                 590        
 Pro Pro Ser Leu Ser Lys Glu Leu Thr Ser Ser Leu Ala Gly Val Gly
         595                 600                 605            
 Asp Val Ser Phe Asp Ser Asp Ser Gln Phe Pro Leu Asp Glu Leu Lys
     610                 615                 620                
 Ile Asp Pro Leu Thr Leu Asp Gly Leu His Met Leu Asn Asp Pro Asp
 625                 630                 635                 640
 Met Val Leu Ala Asp Pro Ala Thr Glu Asp Thr Phe Arg Met Asp Arg
                 645                 650                 655    
 Leu
    



      <210> 713
      <211> 127
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(127)
      <223> Xaa = any amino acid or nothing 


      <400> 713
 Arg Pro Pro Pro Trp Gly Thr Pro Thr Leu Arg His Ser Phe Arg Lys
   1               5                  10                  15    
 His Leu Tyr Leu Leu Arg Gly Leu Pro Gly Ser Gly Lys Thr Thr Leu
              20                  25                  30        
 Ala Arg Gln Leu Gln His Asp Phe Pro Arg Ala Leu Ile Phe Ser Thr
          35                  40                  45            
 Asp Asp Phe Phe Phe Arg Glu Asp Gly Ala Tyr Glu Phe Asn Pro Asp
      50                  55                  60                
 Phe Leu Glu Glu Ala His Glu Trp Asn Gln Lys Arg Ala Xaa Ile Ala
  65                  70                  75                  80
 Met Arg Asn Gly Ile Ser Pro Ile Ile Ile Asp Asn Thr Asn Leu His
                  85                  90                  95    
 Ala Trp Glu Met Lys Pro Tyr Ala Val Met Ala Leu Glu Asn Asn Tyr
             100                 105                 110        
 Glu Val Ile Phe Arg Glu Pro Asp Thr Arg Trp Lys Phe Asn Val
         115                 120                 125        



      <210> 714
      <211> 134
      <212> PRT
      <213> Homo sapiens


      <400> 714
 Gly Ile Pro Gly Ser Thr Lys Arg Leu Lys Met Ser Gly Gly Ala Ser
   1               5                  10                  15    
 Ala Thr Gly Pro Arg Arg Gly Pro Pro Gly Leu Glu Asp Thr Thr Ser
              20                  25                  30        
 Lys Lys Lys Gln Lys Asp Arg Ala Asn Gln Glu Ser Lys Asp Gly Asp
          35                  40                  45            
 Pro Arg Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser
      50                  55                  60                
 Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser
  65                  70                  75                  80
 Ser Ser Ser Ser Ser Ser Ser Ser Ser Pro Phe Phe Pro Ser Ser Ser
                  85                  90                  95    
 Gly Ser Ala Ser Thr Pro Gln Glu Glu Gln Thr Lys Glu Glu Leu Leu
             100                 105                 110        
 Leu Asp Trp Arg Gln Ser Ala Glu Glu Val Ile Val Lys Leu Arg Val
         115                 120                 125            
 Gly Val Gly Pro Leu Gln
     130                



      <210> 715
      <211> 53
      <212> PRT
      <213> Homo sapiens


      <400> 715
 Asn Ser Gln Ile Val Ala Phe Ser Leu Ala Val Cys Ala Phe Lys Ile
   1               5                  10                  15    
 Phe Phe Tyr Pro Phe Ser Ser Leu Gln Gln Ser Pro Gly Leu Gly Arg
              20                  25                  30        
 Pro Ile Trp Leu Gln Ile Ala Glu Ser Ala Tyr Arg Phe Thr Leu Gly
          35                  40                  45            
 Ser Val Ala Gly Gly
      50            



      <210> 716
      <211> 144
      <212> PRT
      <213> Homo sapiens


      <400> 716
 Lys Glu Phe Val Thr Ala Val Val Leu Gly Lys Asp Leu Val Pro Arg
   1               5                  10                  15    
 Ile Gly Leu Ser Gln Leu Glu Gly Phe Arg Arg Gln Leu Leu Asp Val
              20                  25                  30        
 Leu Gln Arg Ser Thr Lys Pro Lys Trp Arg Ile Ile Val Gly Ala Thr
          35                  40                  45            
 Lys Cys Ile Pro Lys Ser Glu Leu Pro Glu Glu Val Glu Val Thr Thr
      50                  55                  60                
 Leu Ala Ser Thr Arg Leu Trp Thr His Pro Ser Asp Leu Thr Ile Ala
  65                  70                  75                  80
 Leu Ser Ala Ser Thr Pro Leu Tyr Pro Pro Gly Arg Ile Ile His Val
                  85                  90                  95    
 Val His Asn His Pro Ala Glu Gln Cys Cys Cys Cys Glu Gln Glu Glu
             100                 105                 110        
 Pro Thr Ser Phe Ala Ile Trp Gly Asp Asn Lys Ala Asn Asn Glu Val
         115                 120                 125            
 Ile Ile Ser Pro Ala Cys Ile Ala Ala Ala Arg Arg Ile Lys Leu Arg
     130                 135                 140                





      <210> 717
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 717
 Ile Arg Glu Val Gln Lys Leu Val Glu Ser Gly Val Asp Val Asn Ser
   1               5                  10                  15    
 Gln Asn Glu Val Asn Gly Trp Thr Cys Leu His Trp Ala Cys Lys Arg
              20                  25                  30        
 Asn His Gly Gln Val Val Ser Tyr Leu Leu Lys Ser Gly Ala Asp Lys
          35                  40                  45            
 Glu Ile Leu Thr Thr Lys Gly Glu Met Pro Val Gln Leu Thr Ser Arg
      50                  55                  60                
 Arg Glu Ile Arg Lys Ile Met Gly Val Glu Glu Glu Asp Asp Asp Asp
  65                  70                  75                  80
 Asp Asp Asp Asp Asn Leu Pro Gln Leu Lys Lys Glu Ser Glu Leu Pro
                  85                  90                  95    
 Phe Val Pro Asn Tyr Leu Ala Asn Pro Ala Phe Pro Phe Ile Tyr Thr
             100                 105                 110        
 Pro Thr Ala Glu Asp Ser Ala Gln Met Gln Asn Gly Gly Pro Ser Thr
         115                 120                 125            
 Pro Pro Ala Ser Pro Pro Ala Asp Gly Glu Ala Ala Ala Leu Arg Ile
     130                 135                 140                
 Thr
 145



      <210> 718
      <211> 132
      <212> PRT
      <213> Homo sapiens


      <400> 718
 Pro Ser Ser Ala Thr Val Cys Ser Phe Ile Glu Gln Gln Phe Val Gln
   1               5                  10                  15    
 Gln Lys Gly Gln Arg Phe Gly Leu Gly Ser Leu Ala His Ser Ile Pro
              20                  25                  30        
 Leu Gly Gln Ala Asp Pro Ser Leu Ala Pro Tyr Ile Ile Asp Leu Pro
          35                  40                  45            
 Ser Trp Thr Gln Phe Arg Gln Asp Thr Gly Thr Met Arg Ala Val Arg
      50                  55                  60                
 Arg His Leu Phe Pro Gln His Ser Ala Pro Gly Arg Gly Val Val Trp
  65                  70                  75                  80
 Glu Trp Leu Ser Asp Asp Gly Ser Trp Thr Ala Tyr Glu Ala Ser Val
                  85                  90                  95    
 Cys Asp Tyr Leu Glu Gln Gln Val Ala Arg Gly Asn Gln Leu Val Asp
             100                 105                 110        
 Leu Ala Pro Leu Gly Tyr Asn Tyr Thr Val Asn Tyr Thr Thr His Thr
         115                 120                 125            
 Gln Thr Cys Ile
     130        



      <210> 719
      <211> 111
      <212> PRT
      <213> Homo sapiens


      <400> 719
 Gly Trp Gln His Arg Glu Gly Glu Arg Lys Val Gly Arg Gly Arg Gly
   1               5                  10                  15    
 Val Leu Arg Gly Gly Gly Gly Thr Gly Arg Ala Pro His Leu Ser Asp
              20                  25                  30        
 Ala Cys Val His Ile Gly Val Leu Gly Ala Leu Leu Gln Ser Ser Ala
          35                  40                  45            
 Ser Met Asp Ala His Pro Ala Thr Ala Asp Asn His Gly Tyr Thr Ala
      50                  55                  60                
 Leu His Trp Ala Cys Tyr Asn Gly His Glu Thr Cys Val Glu Leu Leu
  65                  70                  75                  80
 Leu Glu Gln Glu Val Phe Gln Lys Thr Asp Gly Tyr Ala Phe Ser Pro
                  85                  90                  95    
 Leu His Cys Ala Val Ile Asn Asp Asn Asp Cys Ala Ala Asp Met
             100                 105                 110    



      <210> 720
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 720
 Val Ile Ala Glu Asn Gln Gly Lys Ile Lys Thr Tyr Ile Ser Gln Val
   1               5                  10                  15    
 Cys Asp Asp Ser Met Val Cys Arg Leu Asp Ser Ala Val His Met Ala
              20                  25                  30        
 Gly Leu Arg Leu Leu Thr Asn Met Thr Val Thr Asn His Cys Gln His
          35                  40                  45            
 Leu Leu Ser Tyr Ser Phe Pro Asp Phe Ser Ala Leu Leu Phe Leu Gly
      50                  55                  60                
 Asn His Phe Thr Lys Ile Gln Ile Met Lys Leu Ile Ile Asn Phe Thr
  65                  70                  75                  80
 Glu Asn Pro Ala Met Thr Arg Glu Leu Val Ser Cys Lys Val Pro Ser
                  85                  90                  95    
 Glu Leu Ile Ser Leu Phe Asn Lys Glu Trp Asp Arg Glu Ile Pro Pro
             100                 105                 110        
 Asn Ile Leu Thr Leu Phe Glu Asn Ile Asn Asp Asp Ile Asn Asn Glu
         115                 120                 125            
 Gly His Val
     130    



      <210> 721
      <211> 89
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(89)
      <223> Xaa = any amino acid or nothing 


      <400> 721
 Leu Asp Leu Ile Arg Leu Leu Gly Arg Gly Thr Asp Lys Arg Ser Lys
   1               5                  10                  15    
 Phe Lys Lys Leu Met Lys Gln Gly Val Ala Ala Leu Glu Gly Ser Ala
              20                  25                  30        
 Leu Ala Asn Gly Arg Ala Leu Ser Ala Gly Ser Pro Pro Val Pro Pro
          35                  40                  45            
 Gly Trp Asn Pro Asn Ser Ser Ser Gly Lys Gly Ser Xaa Gly Asn Ala
      50                  55                  60                
 Gly Ser Tyr Ile Pro Ser Tyr Thr Ser Gly Tyr Pro Ser Ala His Gln
  65                  70                  75                  80
 Glu Ala Met Gln Gln Pro Gln Leu Met
                  85                



      <210> 722
      <211> 179
      <212> PRT
      <213> Homo sapiens


      <400> 722
 Asp Phe Gly Arg Gly Leu Ala Glu Arg Phe Leu Thr Ala Gly Arg Thr
   1               5                  10                  15    
 Asp Pro Ala His Asp Val Arg Val Ala Val Val Gln Tyr Ser Gly Thr
              20                  25                  30        
 Gly Gln Gln Arg Pro Glu Arg Ala Ser Leu Gln Phe Leu Gln Asn Tyr
          35                  40                  45            
 Thr Ala Leu Ala Ser Ala Val Asp Ala Met Asp Phe Ile Asn Asp Ala
      50                  55                  60                
 Thr Asp Val Asn Asp Ala Leu Gly Tyr Val Thr Arg Phe Tyr Arg Glu
  65                  70                  75                  80
 Ala Ser Ser Gly Ala Ala Lys Lys Arg Leu Leu Leu Phe Ser Asp Gly
                  85                  90                  95    
 Asn Ser Gln Gly Ala Thr Pro Ala Ala Ile Glu Lys Ala Val Gln Glu
             100                 105                 110        
 Ala Gln Arg Ala Gly Ile Glu Ile Phe Val Val Val Val Gly Arg Gln
         115                 120                 125            
 Val Asn Glu Pro His Ile Arg Val Leu Val Thr Gly Lys Thr Ala Glu
     130                 135                 140                
 Tyr Asp Val Ala Tyr Gly Glu Ser His Leu Val Arg Val Pro Ser Tyr
 145                 150                 155                 160
 Gln Ala Leu Leu Arg Gly Val Phe His Gln Thr Val Ser Arg Lys Val
                 165                 170                 175    
 Ala Leu Gly
            



      <210> 723
      <211> 107
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(106)
      <223> Xaa = any amino acid or nothing 


      <400> 723
 Leu Val Ala Tyr Ser Asn Ser His Cys Gly Leu Trp Cys Arg Ala Gly
   1               5                  10                  15    
 Thr Thr Gln Ala Pro Ala Gly Gly Gly Val Gly Leu Pro Arg Gly Leu
              20                  25                  30        
 Ser Leu Arg Leu Phe Phe Pro Gln Glu Pro Leu Glu Arg Pro Pro Trp
          35                  40                  45            
 Leu Pro Arg Gly Thr Pro Pro Pro Gln Ser Pro Arg Leu Pro Pro Arg
      50                  55                  60                
 Pro Ser Leu Leu His Pro His Pro Ser Pro Pro Thr Ala Thr Gly Ala
  65                  70                  75                  80
 Arg Leu Tyr Asp Pro Ala Ala Pro Pro Ser Ser Asp Ser Thr Cys Glu
                  85                  90                  95    
 Pro Pro Xaa Pro Asn Arg Pro Arg His Glu
             100                 105    



      <210> 724
      <211> 105
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(103)
      <223> Xaa = any amino acid or nothing 


      <400> 724
 Pro Gln Pro Gln Val Gln Asn Met Gln Gly Arg Leu Phe Ser Leu His
   1               5                  10                  15    
 Val Phe Cys Val Val Leu Lys Leu Leu Ala Gly Ala Val Arg Gln Asp
              20                  25                  30        
 Lys Glu Arg Lys Tyr Arg Cys Thr Gly Lys Glu Glu Glu Thr Leu Pro
          35                  40                  45            
 Leu Phe Phe Arg Tyr Met Ile Val Cys Phe Xaa Asn Lys Lys Glu Ser
      50                  55                  60                
 Thr Glu Lys Leu Leu Asn Leu Met Asn Glu Phe Ile Lys Val Thr Arg
  65                  70                  75                  80
 Tyr Lys Val Ser Ile Gln Lys Ser Val Gly Phe Leu His Gly Arg Asn
                  85                  90                  95    
 Asn Cys Thr Trp Lys Asn Val
             100            



      <210> 725
      <211> 153
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(152)
      <223> Xaa = any amino acid or nothing 


      <400> 725
 Ser Lys Ala His Gly Ser Thr Glu Leu Gly Glu Ser Thr Val Ser Ala
   1               5                  10                  15    
 Ser Pro Thr Leu Pro Ser Leu Leu Ile Pro Cys Val Leu Tyr Phe Val
              20                  25                  30        
 Leu Ile Ser Trp Tyr Ser Gln Gln Ile Ala Val Ile His Cys Lys Gly
          35                  40                  45            
 His Gln Lys Glu Asn Thr Ala Ile Ala His Ser Ser Gln Lys Ala Asp
      50                  55                  60                
 Ser Ala Ala Gln Val Ser Ala Arg Leu Ser Val Thr Pro Val Asn Leu
  65                  70                  75                  80
 Lys Pro Thr Val Ser Phe Pro Gln Pro Asp Leu Pro Asp Asn Pro Val
                  85                  90                  95    
 Tyr Ser Thr Thr Thr Glu Lys Leu Ala Ser Asp Leu Arg Ala Asn Lys
             100                 105                 110        
 Asn Gln Glu Ser Xaa Xaa Ile Leu Pro Asp Ser Gly Ile Phe Ile Pro
         115                 120                 125            
 Xaa Thr Xaa Thr Ser Tyr Leu Gln Ser Thr Thr His Leu Arg Arg Ala
     130                 135                 140                
 Lys Leu Pro Gln Leu Leu Arg Arg
 145                 150        



      <210> 726
      <211> 213
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(207)
      <223> Xaa = any amino acid or nothing 


      <400> 726
 Val Pro Gly Leu Ser Pro Ser Val Ala Ala Pro Gly Arg Pro Arg Ala
   1               5                  10                  15    
 Pro Val Arg Trp His Trp Val Arg Ala Leu Leu Cys Pro Gln Leu Phe
              20                  25                  30        
 His Ser Leu Pro His Gln Val Leu Thr Glu Gln Gln Gln Glu Gln Ala
          35                  40                  45            
 Ala His Asn Asn Phe Asn Phe Asp His Pro Asp Ala Phe Asp Phe Asp
      50                  55                  60                
 Leu Ile Ile Ser Thr Leu Lys Lys Leu Glu Glu Gly Lys Ser Val Lys
  65                  70                  75                  80
 Val Pro Ile Tyr Asp Phe Thr Thr His Ser Arg Lys Lys Asp Trp Lys
                  85                  90                  95    
 Thr Leu Tyr Gly Ala Asn Val Ile Ile Phe Glu Gly Ile Met Ala Phe
             100                 105                 110        
 Ala Asp Lys Thr Arg Val Leu Ser Ser Trp Asp Met Lys Ile Phe Val
         115                 120                 125            
 Asp Thr Asp Ser Asp Ile Arg Leu Ala Leu Arg Arg Leu Arg Arg Asp
     130                 135                 140                
 Ile Ser Glu Arg Gly Arg Asp Ile Glu Gly Val Ile Lys Gln Tyr Asn
 145                 150                 155                 160
 Lys Phe Val Lys Pro Ser Phe Asp Gln Tyr Ile Gln Pro Thr Met Gln
                 165                 170                 175    
 Pro Ala Asp Ile Val Val Leu Arg Gly Ser Gly Asn Thr Val Gly His
             180                 185                 190        
 Arg Pro Xaa Leu Leu Gln His Val His Ser Gln Leu Glu Glu Arg
         195                 200                 205        



      <210> 727
      <211> 200
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(199)
      <223> Xaa = any amino acid or nothing 


      <400> 727
 Leu Pro Ser Leu Ser Leu Arg Leu Leu His Asn Cys Ala Pro Leu Val
   1               5                  10                  15    
 Leu Asp Lys Thr Ile Ser Phe Ile Ile Cys Ile Ile Thr Arg Pro Ser
              20                  25                  30        
 Ile Met Thr Glu Ile Arg Xaa Tyr Thr Leu His Gly Val Asn Ala Arg
          35                  40                  45            
 Asn Gln Asn Ser Arg Leu Ala Ala Thr Lys Pro Ser Ser Val Arg Ser
      50                  55                  60                
 Gly Leu Phe Gln Leu Ser Ser Ser Ser Ala Arg Gln Pro Thr Pro Gln
  65                  70                  75                  80
 Arg Pro Ala Pro Arg Ala Ala Arg Leu Pro Arg Pro Pro Pro Gly Pro
                  85                  90                  95    
 Arg Pro Pro Pro Pro Ala Thr Pro Arg Pro Pro Pro Pro Gln Leu Pro
             100                 105                 110        
 Ala Leu Pro Pro Pro Ala Ala Ala Ala Leu Arg Gly Met Pro Gly Ala
         115                 120                 125            
 Val Ala Ala Thr Ala Ala Pro Ala Pro Arg Arg Gln Glu Pro Gly Ile
     130                 135                 140                
 Pro Pro Arg Arg Ala Pro Glu Ala Pro Gly Ser Pro Ser Ser Ala Val
 145                 150                 155                 160
 Leu Pro Gly Arg Asp Gly Ala Gly Arg Ala Arg Gly Arg Ala Trp Val
                 165                 170                 175    
 Trp Val Pro Pro Arg Ala Gly Arg Arg Trp Arg Gln Val Pro Glu Arg
             180                 185                 190        
 Gly Ala His Arg Gly Ala Gln
         195                



      <210> 728
      <211> 132
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(130)
      <223> Xaa = any amino acid or nothing 


      <400> 728
 Ala Ser Cys Gly Gln Xaa His Gly Cys Thr Ser Ser Pro Arg Arg Gly
   1               5                  10                  15    
 Val Ser Ala Leu Ser Ala Ser Pro Leu Pro Ser Ser Ser Cys Cys Trp
              20                  25                  30        
 Pro Cys Cys Ala Ser Gly Ala Gly Gly Asp Pro Arg Ala Gly Pro Gly
          35                  40                  45            
 Ala Trp Ser Gly Gln His Asp Pro Lys Leu Lys Ala Thr Ser Glu Glu
      50                  55                  60                
 Ala Gly Leu Gly Leu Gly Val Ser Pro Gly Asn Gly Gly Gly Arg Gln
  65                  70                  75                  80
 Gly Gln Ala Gly Thr Leu Pro Gly Ser Pro Arg Gln Ala Arg Asp Leu
                  85                  90                  95    
 Val Val Ser Xaa Ala Ser Cys Gly Gln Ala Gly Tyr Pro Arg Gly Thr
             100                 105                 110        
 Gly Ser Gly Gly Leu Xaa Ala Ala Val Pro Ser Leu Pro Ser Gln Ala
         115                 120                 125            
 Cys Gly
     130



      <210> 729
      <211> 174
      <212> PRT
      <213> Homo sapiens


      <400> 729
 Arg Arg Ser Pro Thr Gly Pro Ser Gly Leu Lys Ala Ala Val Leu Thr
   1               5                  10                  15    
 Leu Ala Val Leu Phe Leu Thr Gly Ser Gln Ala Arg His Phe Trp Gln
              20                  25                  30        
 Gln Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala
          35                  40                  45            
 Thr Val Tyr Val Asp Val Leu Lys Asp Ser Gly Lys Asp Ser Val Thr
      50                  55                  60                
 Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu
  65                  70                  75                  80
 Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met
                  85                  90                  95    
 Ser Lys Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp
             100                 105                 110        
 Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys
         115                 120                 125            
 Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu
     130                 135                 140                
 His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Asp Ala Asp
 145                 150                 155                 160
 Arg Arg Arg Ala His Val
                 165    



      <210> 730
      <211> 235
      <212> PRT
      <213> Homo sapiens


      <400> 730
 Lys Glu Gly Thr Gln Thr Ala Gly Arg Asp Arg Tyr Leu Ala Ser Met
   1               5                  10                  15    
 Glu Ser Pro Glu Glu Pro Gly Ala Ser Met Asp Glu Asn Tyr Phe Val
              20                  25                  30        
 Asn Tyr Thr Phe Lys Asp Arg Ser His Ser Gly Arg Val Ala Gln Gly
          35                  40                  45            
 Ile Met Lys Leu Cys Leu Glu Glu Glu Leu Phe Ala Asp Val Thr Ile
      50                  55                  60                
 Ser Val Glu Gly Arg Glu Phe Gln Leu His Arg Leu Val Leu Ser Ala
  65                  70                  75                  80
 Thr Glu Ala Ala Ser Phe Arg Ser Met Phe His Phe Gln Pro Glu Arg
                  85                  90                  95    
 Arg Pro Thr Thr Gly Val His Cys Ala Cys Lys Asp Phe Ser Glu Ser
             100                 105                 110        
 Val Phe Gln Leu Leu Val Asp Tyr Ile Tyr His Gly Thr Val Lys Leu
         115                 120                 125            
 Arg Ala Glu Glu Leu Gln Glu Ile Tyr Glu Val Ser Asp Met Leu Gln
     130                 135                 140                
 Leu Thr Ser Leu Phe Glu Glu Cys Phe Arg Phe Leu Ala Arg Thr Val
 145                 150                 155                 160
 Gln Ala Gly Asn Cys Leu Gln Val Met Trp Leu Ala Asp Arg His Ser
                 165                 170                 175    
 Asp His Glu Leu Tyr Thr Ala Ala Lys His Cys Ala Lys Thr His Leu
             180                 185                 190        
 Ala Gln Leu Gln Asn Thr Glu Glu Phe Leu His Leu Pro Arg Arg Leu
         195                 200                 205            
 Leu Thr His Ile Ile Ser Gly Lys Phe Arg Glu Gly Thr His His Thr
     210                 215                 220                
 Gln Leu Leu Gly Tyr Asp Val Gln
 225                 230        



      <210> 731
      <211> 135
      <212> PRT
      <213> Homo sapiens


      <400> 731
 Ile Arg Leu Asn Thr Lys Glu Asp Lys Asn Gly Val Pro Asp Leu Val
   1               5                  10                  15    
 Ala Leu Leu Ala Val Arg Asp Thr Pro Asp Glu Glu Pro Val Asp Ser
              20                  25                  30        
 Asp Thr Ser Glu Ser Asp Ser Gln Glu Ser Gly Asp Gln Glu Thr Glu
          35                  40                  45            
 Glu Leu Asp Asn Pro Glu Phe Val Ala Ile Val Ala Tyr Thr Asp Pro
      50                  55                  60                
 Ser Asp Pro Trp Ala Arg Glu Glu Met Leu Lys Ile Ala Ser Val Ile
  65                  70                  75                  80
 Glu Ser Leu Gly Trp Ser Asp Glu Lys Asp Lys Arg Asp Pro Leu Arg
                  85                  90                  95    
 Gln Val Leu Ser Val Met Ser Lys Asp Thr Asn Gly Thr Arg Val Lys
             100                 105                 110        
 Val Glu Glu Ala Gly Arg Glu Gly Trp Asp Ala Val Val Leu Arg Lys
         115                 120                 125            
 Ala Gly Asp
     130    



      <210> 732
      <211> 255
      <212> PRT
      <213> Homo sapiens


      <400> 732
 Pro Ser Leu Arg Gln Ser Trp His Glu Gly Lys Met Ala Glu Ser Gly
   1               5                  10                  15    
 Gly Ser Ser Gly Gly Ala Gly Gly Gly Gly Ala Phe Gly Ala Gly Pro
              20                  25                  30        
 Gly Pro Glu Arg Pro Asn Ser Thr Ala Asp Lys Asn Gly Ala Leu Lys
          35                  40                  45            
 Cys Thr Phe Ser Ala Pro Ser His Ser Thr Ser Leu Leu Gln Gly Leu
      50                  55                  60                
 Ala Thr Leu Arg Leu Met Gly Gln Leu Leu Asp Val Val Leu Thr Ile
  65                  70                  75                  80
 Asn Arg Glu Ala Phe Pro Ala His Lys Val Val Leu Ala Ala Cys Ser
                  85                  90                  95    
 Asp Tyr Phe Arg Ala Met Phe Thr Gly Gly Met Arg Glu Ala Ser Gln
             100                 105                 110        
 Asp Val Ile Glu Leu Lys Gly Val Ser Ala Ser Gly Met Arg His Ile
         115                 120                 125            
 Ile Asp Phe Ala Tyr Ser Ala Glu Val Thr Leu Asp Leu Asp Cys Val
     130                 135                 140                
 Gln Asp Val Leu Gly Ala Ala Ser Phe Leu Gln Met Leu Pro Val Val
 145                 150                 155                 160
 Glu Leu Cys Glu Glu Phe Leu Lys Ala Ala Met Ser Val Glu Thr Cys
                 165                 170                 175    
 Leu Asn Ile Gly Gln Met Ala Thr Thr Phe Ser Leu Ala Ser Leu Arg
             180                 185                 190        
 Glu Ser Val Asp Ala Phe Thr Phe Arg His Phe Leu Gln Ile Ala Glu
         195                 200                 205            
 Glu Glu Asp Phe Leu Arg Leu Pro Leu Glu Arg Leu Val Phe Phe Leu
     210                 215                 220                
 Gln Ser Asn Arg Leu Gln Ser Cys Ala Glu Ile Asp Leu Phe Arg Ala
 225                 230                 235                 240
 Ala Val Arg Trp Leu Gln His Asp Pro Ala Arg Arg Pro
                 245                 250            



      <210> 733
      <211> 61
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(61)
      <223> Xaa = any amino acid or nothing 


      <400> 733
 Ser Ala Thr Pro Trp Leu Pro Thr Gly Leu Ala Ala Pro Thr Pro Gly
   1               5                  10                  15    
 Leu Ala Ala Pro Gly Thr Arg Ser Pro Pro Gly Gln Thr Xaa Pro Glu
              20                  25                  30        
 Arg Ser Pro Ala Ala Ser Pro Lys Arg Pro Glu Arg Pro Ala Gln Asp
          35                  40                  45            
 Ser Gln Pro Pro Arg Gln Pro Pro Pro Pro Pro Pro Arg
      50                  55                  60    



      <210> 734
      <211> 61
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(61)
      <223> Xaa = any amino acid or nothing 


      <400> 734
 Ser Ala Thr Pro Trp Leu Pro Thr Gly Leu Ala Ala Pro Thr Pro Gly
   1               5                  10                  15    
 Leu Ala Ala Pro Gly Thr Arg Ser Pro Pro Gly Gln Thr Xaa Pro Glu
              20                  25                  30        
 Arg Ser Pro Ala Ala Ser Pro Lys Arg Pro Glu Arg Pro Ala Gln Asp
          35                  40                  45            
 Ser Gln Pro Pro Arg Gln Pro Pro Pro Pro Pro Pro Arg
      50                  55                  60    



      <210> 735
      <211> 51
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(51)
      <223> Xaa = any amino acid or nothing 


      <400> 735
 Ser Phe Leu Ser Phe Ile Lys Pro Ser Pro Leu Gly Gly Gly Pro Asp
   1               5                  10                  15    
 Pro Asn Ser Pro Leu Arg Gly Ala Val Xaa Asn Ser Thr Ala Leu Arg
              20                  25                  30        
 Leu Lys Arg Trp Gly Leu Glu Lys Pro Gly Leu Pro Gln Ile Asn Leu
          35                  40                  45            
 Leu Leu Ala
      50    



      <210> 736
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 736
 Trp Ala Leu Gln Leu His Pro Glu Pro Glu Leu Pro Ser Arg Arg Gly
   1               5                  10                  15    
 Thr Val Val Ser Gly Val Trp Thr Gly Val Ala Met Ile Arg Phe Ile
              20                  25                  30        
 Leu Ile Gln Asn Arg Ala Gly Lys Thr Arg Leu Ala Lys Trp Tyr Met
          35                  40                  45            
 Gln Phe Asp Asp Asp Glu Lys Gln Lys Leu Ile Glu Glu Val His Ala
      50                  55                  60                
 Val Val Thr Val Arg Asp Ala Lys His Thr Asn Phe Val Thr Ser Ser
  65                  70                  75                  80
 Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser
                  85                  90                  95    
 Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser
             100                 105                 110        
 Ser Ser Leu Arg Asn Phe Lys Ile Ile Tyr Arg Arg Tyr Ala Gly Leu
         115                 120                 125            
 Tyr Phe Cys Ile Cys Val Asp Val Asn Asp Asn Asn Leu Ala Tyr Leu
     130                 135                 140                
 Glu
 145



      <210> 737
      <211> 132
      <212> PRT
      <213> Homo sapiens


      <400> 737
 Ser Gln Ser Arg Arg Val Ile Met Asn Ser Ala Ala Gly Phe Ser His
   1               5                  10                  15    
 Leu Asp Arg Arg Glu Arg Val Leu Lys Leu Gly Glu Ser Phe Glu Lys
              20                  25                  30        
 Gln Pro Arg Cys Ala Phe His Thr Val Arg Tyr Asp Phe Lys Pro Ala
          35                  40                  45            
 Ser Ile Asp Thr Ser Ser Glu Gly Tyr Leu Glu Val Gly Glu Gly Glu
      50                  55                  60                
 Gln Val Thr Ile Thr Leu Pro Asn Ile Glu Gly Ser Thr Pro Pro Val
  65                  70                  75                  80
 Thr Val Phe Lys Gly Ser Lys Lys Pro Tyr Leu Lys Glu Cys Ile Leu
                  85                  90                  95    
 Ile Ile Asn His Asp Thr Gly Glu Cys Arg Leu Glu Lys Leu Ser Ser
             100                 105                 110        
 Asn Ile Thr Val Lys Lys Thr Arg Val Glu Gly Ser Ser Lys Ile His
         115                 120                 125            
 Tyr Arg Lys Glu
     130        



      <210> 738
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 738
 Phe Val Gly Arg Ile Leu Ile Ala Val Arg Arg Pro Tyr Leu Gly Pro
   1               5                  10                  15    
 Gly Leu Thr Pro Ala Ala Leu Pro Ala Pro Pro Ser Ser Ile Met Ala
              20                  25                  30        
 Ser Pro Arg Thr Arg Lys Val Leu Lys Glu Val Arg Val Gln Asp Glu
          35                  40                  45            
 Asn Asn Val Cys Phe Glu Cys Gly Ala Phe Asn Pro Gln Trp Val Ser
      50                  55                  60                
 Val Thr Tyr Gly Ile Trp Ile Cys Leu Glu Cys Ser Gly Arg His Arg
  65                  70                  75                  80
 Gly Leu Gly Val His Leu Ser Phe Val Arg Ser Val Thr Met Asp Lys
                  85                  90                  95    
 Trp Lys Asp Ile Glu Leu Glu Lys Met Lys Ala Gly Gly Asn Ala Lys
             100                 105                 110        
 Phe Arg Glu Phe Leu Glu Ser Gln Glu Asp Tyr Asp Pro Cys Trp Phe
         115                 120                 125            
 Leu Tyr Glu Arg Tyr Asn Ser Lys Ala
     130                 135        



      <210> 739
      <211> 983
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(968)
      <223> Xaa = any amino acid or nothing 


      <400> 739
 Ala Arg Gly Ala Asp Val Ala Lys Lys Leu Asp Lys Thr Thr Ile Met
   1               5                  10                  15    
 Gly Ser Gly Pro Ile Asp Pro Lys Glu Leu Leu Lys Gly Leu Asp Ser
              20                  25                  30        
 Phe Leu Asn Arg Asp Gly Glu Val Lys Ser Val Asp Gly Ile Ser Lys
          35                  40                  45            
 Ile Phe Ser Leu Met Lys Glu Ala Arg Lys Met Val Ser Arg Cys Thr
      50                  55                  60                
 Tyr Leu Asn Ile Leu Leu Gln Thr Arg Ser Pro Glu Ile Leu Val Lys
  65                  70                  75                  80
 Phe Ile Asp Val Gly Gly Tyr Lys Leu Leu Asn Asn Trp Leu Thr Tyr
                  85                  90                  95    
 Ser Lys Thr Thr Asn Asn Ile Pro Leu Leu Gln Gln Ile Leu Leu Thr
             100                 105                 110        
 Leu Gln His Leu Pro Leu Thr Val Asp His Leu Lys Ala Gly Thr Thr
         115                 120                 125            
 Gln Ala Xaa Thr Gly Xaa Arg Gln Leu Glu Ala Ser Ser Ser Glu Asp
     130                 135                 140                
 Glu Glu Leu Pro Lys Leu Ala Ser Val Leu Val Ser Asp Trp Met Ala
 145                 150                 155                 160
 Val Ile Arg Phe Gln Ser Ser Thr Gln Pro Cys Xaa Glu Lys Ile Arg
                 165                 170                 175    
 Arg Lys Arg Lys Asp Glu Gly Lys Ser Arg Thr Thr Leu Ser Leu Ser
             180                 185                 190        
 Gly Pro Phe Asp Lys Arg Xaa Arg Leu Glu Pro Arg Gly Xaa Arg Arg
         195                 200                 205            
 Pro Pro Glu Lys Lys Arg Glu Lys Pro Gln Val Ser Ser Asp Pro Gln
     210                 215                 220                
 His Pro Ser His Ala Lys Phe Arg Phe His Leu Asp Leu Glu Leu Glu
 225                 230                 235                 240
 Thr Pro Ser Leu Val Cys Pro Val Lys Lys Asn Ala Ser Thr Val Val
                 245                 250                 255    
 Val Ser Asp Lys Tyr Asn Leu Lys Pro Ile Pro Leu Phe Lys Arg Gln
             260                 265                 270        
 Ser Asn Val Ala Ala Pro Gly Asp Ala Thr Pro Pro Ala Glu Lys Lys
         275                 280                 285            
 Tyr Lys Pro Leu Asn Thr Thr Pro Asn Ala Thr Lys Glu Ile Lys Val
     290                 295                 300                
 Lys Ile Ile Pro Pro Gln Pro Met Glu Gly Leu Gly Phe Leu Asp Ala
 305                 310                 315                 320
 Leu Asn Ser Ala Pro Val Pro Gly Ile Lys Ile Lys Lys Lys Lys Lys
                 325                 330                 335    
 Val Leu Ser Pro Thr Ala Ala Lys Pro Ser Pro Phe Glu Gly Lys Thr
             340                 345                 350        
 Ser Thr Glu Pro Ser Thr Ala Lys Pro Ser Ser Pro Glu Pro Ala Pro
         355                 360                 365            
 Pro Ser Glu Ala Met Asp Ala Asp Arg Pro Gly Thr Pro Val Pro Pro
     370                 375                 380                
 Val Glu Val Pro Glu Leu Met Asp Thr Ala Ser Leu Glu Pro Gly Ala
 385                 390                 395                 400
 Leu Asp Ala Lys Pro Val Glu Ser Pro Gly Asp Pro Asn Gln Leu Thr
                 405                 410                 415    
 Arg Lys Gly Arg Lys Arg Lys Ser Val Thr Trp Pro Glu Glu Gly Lys
             420                 425                 430        
 Leu Arg Glu Tyr Phe Tyr Phe Glu Leu Asp Glu Thr Glu Arg Val Asn
         435                 440                 445            
 Val Asn Lys Ile Lys Asp Phe Gly Glu Ala Ala Lys Arg Glu Ile Leu
     450                 455                 460                
 Ser Asp Arg His Ala Phe Glu Thr Ala Arg Arg Leu Ser His Asp Asn
 465                 470                 475                 480
 Met Glu Glu Lys Val Pro Trp Val Cys Pro Arg Pro Leu Val Leu Pro
                 485                 490                 495    
 Ser Pro Leu Val Thr Pro Gly Ser Asn Ser Gln Glu Arg Tyr Ile Gln
             500                 505                 510        
 Ala Glu Arg Glu Lys Gly Asn Pro Phe Lys Glu Leu Phe Leu Asn Lys
         515                 520                 525            
 Glu Ser Pro His Glu Pro Asp Pro Glu Pro Phe Glu Pro Ile Pro Pro
     530                 535                 540                
 Lys Leu Ile Pro Leu Asp Glu Glu Cys Ser Met Asp Glu Thr Pro Tyr
 545                 550                 555                 560
 Val Glu Thr Leu Glu Pro Gly Gly Ser Gly Gly Ser Pro Asp Gly Ala
                 565                 570                 575    
 Gly Gly Ser Lys Leu Pro Pro Val Leu Ala Asn Leu Met Gly Ser Met
             580                 585                 590        
 Gly Ala Gly Lys Gly Pro Gln Gly Pro Gly Gly Gly Gly Ile Asn Val
         595                 600                 605            
 Gln Glu Ile Leu Thr Ser Ile Met Gly Ser Pro Asn Ser His Pro Ser
     610                 615                 620                
 Glu Glu Leu Leu Lys Gln Pro Asp Tyr Ser Asp Lys Ile Lys Gln Met
 625                 630                 635                 640
 Leu Val Pro His Gly Leu Leu Gly Pro Gly Pro Ile Ala Asn Gly Phe
                 645                 650                 655    
 Pro Pro Gly Gly Pro Gly Gly Pro Lys Gly Met Gln His Phe Pro Pro
             660                 665                 670        
 Gly Pro Gly Gly Pro Met Pro Gly Pro His Gly Gly Pro Gly Gly Pro
         675                 680                 685            
 Val Gly Pro Arg Leu Leu Gly Pro Pro Pro Pro Pro Arg Gly Gly Asp
     690                 695                 700                
 Pro Phe Trp Asp Gly Pro Gly Asp Pro Met Arg Gly Gly Pro Met Arg
 705                 710                 715                 720
 Gly Gly Pro Gly Pro Gly Pro Gly Pro Tyr His Arg Gly Arg Gly Gly
                 725                 730                 735    
 Arg Gly Gly Asn Glu Pro Pro Pro Pro Pro Pro Pro Phe Arg Gly Ala
             740                 745                 750        
 Arg Gly Gly Arg Ser Gly Gly Gly Pro Pro Asn Gly Arg Gly Gly Pro
         755                 760                 765            
 Gly Gly Gly Met Val Gly Gly Gly Gly His Arg Pro His Glu Gly Pro
     770                 775                 780                
 Gly Gly Gly Met Gly Asn Ser Ser Gly His Arg Pro His Glu Gly Pro
 785                 790                 795                 800
 Gly Gly Gly Met Gly Ser Gly His Arg Pro His Glu Gly Pro Gly Gly
                 805                 810                 815    
 Ser Met Gly Gly Gly Gly Gly His Arg Pro His Glu Gly Pro Gly Gly
             820                 825                 830        
 Gly Ile Ser Gly Gly Ser Gly His Arg Pro His Glu Gly Pro Gly Gly
         835                 840                 845            
 Gly Met Gly Ala Gly Gly Gly His Arg Pro His Glu Gly Pro Gly Gly
     850                 855                 860                
 Ser Met Gly Gly Ser Gly Gly His Arg Pro His Glu Gly Pro Gly His
 865                 870                 875                 880
 Gly Gly Pro His Gly His Arg Leu His Asp Val Pro Gly His Arg Gly
                 885                 890                 895    
 His Asp His Arg Gly Pro Pro Pro His Glu His Arg Gly His Asp Gly
             900                 905                 910        
 Pro Gly His Gly Xaa Gly Gly His Arg Gly His Asp Trp Lys Ala Thr
         915                 920                 925            
 Thr Leu Gly Gly Asp Met Ser Asn Arg Pro Val Cys Arg His Phe Met
     930                 935                 940                
 Met Lys Val Asn Cys Arg Tyr Glu Asn Asn Cys Ala Phe Tyr His Pro
 945                 950                 955                 960
 Gly Val Asn Gly Pro Pro Leu Pro
                 965            



      <210> 740
      <211> 46
      <212> PRT
      <213> Homo sapiens


      <400> 740
 Tyr Cys Thr Ala Ile Lys Lys Asp Glu Phe Met Ser Phe Ala Gly Thr
   1               5                  10                  15    
 Trp Met Lys Leu Glu Thr Ile Ile Leu Ser Lys Leu Gln Gln Gly Gln
              20                  25                  30        
 Lys Thr Lys His Arg Ile Phe Ser Leu Thr Ser Gly Ser
          35                  40                  45



      <210> 741
      <211> 203
      <212> PRT
      <213> Homo sapiens


      <400> 741
 Arg Ala Ala Ser Arg Gly Leu Arg Pro Ala Lys Pro Arg Arg Thr Thr
   1               5                  10                  15    
 Met Leu Lys Ala Lys Ile Leu Phe Val Gly Pro Cys Glu Ser Gly Lys
              20                  25                  30        
 Thr Val Leu Ala Asn Phe Leu Thr Glu Ser Ser Asp Ile Thr Glu Tyr
          35                  40                  45            
 Ser Pro Thr Gln Gly Val Arg Ile Leu Glu Phe Glu Asn Pro His Val
      50                  55                  60                
 Thr Ser Asn Asn Lys Gly Thr Gly Cys Glu Phe Glu Leu Trp Asp Cys
  65                  70                  75                  80
 Gly Gly Asp Ala Lys Phe Glu Ser Cys Trp Pro Ala Leu Met Lys Asp
                  85                  90                  95    
 Ala His Gly Val Val Ile Val Phe Asn Ala Glu Ser Gln Ala Thr Gly
             100                 105                 110        
 Arg Lys Trp Arg Trp Gly Ile Pro Ala Phe Val Gln Gln Pro Ser Leu
         115                 120                 125            
 Gln Asp Thr Gln Cys Ile Leu Ile Ala His His Lys Pro Gly Ser Gly
     130                 135                 140                
 Asp Asp Lys Gly Ser Leu Ser Leu Ser Pro Pro Leu Asn Lys Leu Lys
 145                 150                 155                 160
 Leu Val His Ser Asn Leu Glu Asp Asp Pro Glu Glu Ile Arg Met Glu
                 165                 170                 175    
 Phe Ile Lys Tyr Leu Lys Ser Ile Ile Asn Ser Met Ser Glu Ser Arg
             180                 185                 190        
 Asp Arg Glu Glu Met Ser Ile Met Thr
         195                 200    



      <210> 742
      <211> 437
      <212> PRT
      <213> Homo sapiens


      <400> 742
 His Pro Gly Leu His Gln His Pro Ala Val Pro Val Gln Pro Gly Pro
   1               5                  10                  15    
 Ala Gly Ala Glu Arg Ala Gly Arg Ala Gly His Thr Arg Gly Pro Gln
              20                  25                  30        
 Gly Pro Ala Gln Arg Ala Leu Leu Gly Val Ala Gly Gly Leu Pro Ala
          35                  40                  45            
 Ala Ser Ser Pro Glu His Pro Thr Cys Arg Arg Arg Val Gly Gln Asp
      50                  55                  60                
 Pro Ala Leu Pro Ala Asp Thr Leu Leu Leu Gly Asp Gly Asp Ala Gly
  65                  70                  75                  80
 Ser Leu Thr Ser Ala Ser Gln Arg Phe Tyr Arg Val Leu His Ala Ala
                  85                  90                  95    
 Ala Ser Ala Gly Glu His Glu Lys Val Val Gln Gly Leu Phe Asp Asn
             100                 105                 110        
 Phe Leu Arg Leu Arg Leu Arg Asp Ser Ser Leu Gly Ala Val Cys Val
         115                 120                 125            
 Ala Leu Asp Trp Leu Ala Phe Asp Asp Leu Leu Ala Gly Ala Ala His
     130                 135                 140                
 His Ser Gln Ser Phe Gln Leu Leu Arg Tyr Pro Pro Phe Leu Pro Val
 145                 150                 155                 160
 Ala Phe His Val Leu Phe Ala Ser Ser His Thr Pro Arg Ile Thr Phe
                 165                 170                 175    
 Pro Ser Ser Gln Gln Glu Ala Gln Asn Arg Met Ser Gln Met Arg Asn
             180                 185                 190        
 Leu Ile Gln Thr Leu Val Ser Gly Ile Ala Pro Ala Thr Arg Ser Arg
         195                 200                 205            
 Ala Thr Pro Gln Ala Leu Leu Leu Asp Ala Leu Cys Leu Leu Leu Asp
     210                 215                 220                
 Ile Leu Ala Pro Lys Leu Arg Pro Val Ser Thr Gln Leu Tyr Ser Thr
 225                 230                 235                 240
 Arg Glu Lys Gln Gln Leu Ala Ser Leu Val Gly Thr Met Leu Ala Tyr
                 245                 250                 255    
 Ser Leu Thr Tyr Arg Gln Glu Arg Thr Pro Asp Gly Gln Tyr Ile Tyr
             260                 265                 270        
 Arg Leu Glu Pro Asn Val Glu Glu Leu Cys Arg Phe Pro Glu Leu Pro
         275                 280                 285            
 Ala Arg Lys Pro Leu Thr Tyr Gln Thr Lys Gln Leu Ile Ala Arg Glu
     290                 295                 300                
 Ile Glu Val Glu Lys Met Arg Arg Ala Glu Ala Ser Ala Arg Val Glu
 305                 310                 315                 320
 Asn Ser Pro Gln Val Asp Gly Ser Pro Pro Gly Leu Glu Gly Leu Leu
                 325                 330                 335    
 Gly Gly Ile Gly Glu Lys Gly Val His Arg Pro Ala Pro Arg Asn His
             340                 345                 350        
 Glu Gln Arg Leu Glu Ala His His Glu Ala Glu Ala Ala Arg Glu Asp
         355                 360                 365            
 Gln Pro Glu Lys Gly Phe Phe Gly Arg Val Val Val Arg Ser Thr Ala
     370                 375                 380                
 Val Pro Ser Ala Gly Asp Arg Ala Pro Glu Gln Asp Ser Val Glu Arg
 385                 390                 395                 400
 Arg Met Gly Thr Ala Val Gly Arg Ser Glu Val Trp Phe Arg Phe Asn
                 405                 410                 415    
 Glu Gly Val Ser Asn Ala Val Arg Arg Ser Leu Tyr Ile Arg Asp Leu
             420                 425                 430        
 Leu
    



      <210> 743
      <211> 65
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(65)
      <223> Xaa = any amino acid or nothing 


      <400> 743
 Gln Phe Gly Arg Pro Arg Xaa Ala Asp His Leu Arg Leu Gly Val Arg
   1               5                  10                  15    
 Asp Gln Pro Asp Gln His Gly Glu Thr Leu Ser Leu Leu Lys Lys Lys
              20                  25                  30        
 Tyr Lys Ile Ser Gln Ala Trp Trp His Met Pro Val Val Pro Ala Thr
          35                  40                  45            
 Gln Glu Thr Glu Ala Gly Glu Leu Pro Glu Pro Gly Arg Gln Arg Leu
      50                  55                  60                
 Gln
  65



      <210> 744
      <211> 217
      <212> PRT
      <213> Homo sapiens


      <400> 744
 Leu Ser Glu Arg Leu Val Arg Phe Arg Ala Arg Gly Phe Pro Arg Arg
   1               5                  10                  15    
 Gln Ala Asp Phe Ser Ser Leu Val Phe Leu Phe Ala Phe Phe Leu Pro
              20                  25                  30        
 Pro Pro Leu Pro Pro Ser Pro Ser Trp Pro Ser Ala Leu Arg Pro Leu
          35                  40                  45            
 Gln Gly His Leu Tyr Thr Val Pro Ile Arg Glu Gln Gly Asn Ile Tyr
      50                  55                  60                
 Lys Pro Asn Asn Lys Ala Met Ala Asp Glu Leu Ser Glu Lys Gln Val
  65                  70                  75                  80
 Tyr Asp Ala His Thr Lys Glu Ile Asp Leu Val Asn Arg Asp Pro Lys
                  85                  90                  95    
 His Leu Asn Asp Asp Val Val Lys Ile Asp Phe Glu Asp Val Ile Ala
             100                 105                 110        
 Glu Pro Glu Gly Thr His Ser Phe Asp Gly Ile Trp Lys Ala Ser Phe
         115                 120                 125            
 Thr Thr Phe Thr Val Thr Lys Tyr Trp Phe Tyr Arg Leu Leu Ser Ala
     130                 135                 140                
 Leu Phe Gly Ile Pro Met Ala Leu Ile Trp Gly Ile Tyr Phe Ala Ile
 145                 150                 155                 160
 Leu Ser Phe Leu His Ile Trp Ala Val Val Pro Cys Ile Lys Ser Phe
                 165                 170                 175    
 Leu Ile Glu Ile Gln Cys Ile Ser Arg Val Tyr Ser Ile Tyr Val His
             180                 185                 190        
 Thr Val Cys Asp Pro Leu Phe Glu Ala Val Gly Lys Ile Phe Ser Asn
         195                 200                 205            
 Val Arg Ile Asn Leu Gln Lys Glu Ile
     210                 215        



      <210> 745
      <211> 61
      <212> PRT
      <213> Homo sapiens


      <400> 745
 His Pro Ser Lys Asp Ala Phe Val Glu Cys Lys Pro Phe Ile Asn Ile
   1               5                  10                  15    
 Leu Ser Arg Leu Gly Ala Val Ala Gln Ala Cys Asn Pro Ser Thr Leu
              20                  25                  30        
 Gly Gly Gln Gly Gly Trp Ile Thr Cys Gly Arg Glu Phe Glu Thr Ser
          35                  40                  45            
 Leu Thr Asn Ile Val Lys Ser Arg Leu Tyr Gln Lys Ile
      50                  55                  60    



      <210> 746
      <211> 343
      <212> PRT
      <213> Homo sapiens


      <400> 746
 Lys Glu Val Gln Ala Thr Val Ser Arg Ser His Thr Gly Ala Met Glu
   1               5                  10                  15    
 Val Ala Glu Pro Ser Ser Pro Thr Glu Glu Glu Glu Glu Glu Glu Glu
              20                  25                  30        
 His Ser Ala Glu Pro Arg Pro Arg Thr Arg Ser Asn Pro Glu Gly Ala
          35                  40                  45            
 Glu Asp Arg Ala Val Gly Ala Gln Ala Ser Val Gly Ser Arg Ser Glu
      50                  55                  60                
 Gly Glu Gly Glu Ala Ala Ser Ala Asp Asp Gly Ser Leu Asn Thr Ser
  65                  70                  75                  80
 Gly Ala Gly Pro Lys Ser Trp Gln Val Pro Pro Pro Ala Pro Glu Val
                  85                  90                  95    
 Gln Ile Arg Thr Pro Arg Val Asn Cys Pro Glu Lys Val Ile Ile Cys
             100                 105                 110        
 Leu Asp Leu Ser Glu Glu Met Ser Leu Pro Lys Leu Glu Ser Phe Asn
         115                 120                 125            
 Gly Ser Lys Thr Asn Ala Leu Asn Val Ser Gln Lys Met Ile Glu Met
     130                 135                 140                
 Phe Val Arg Thr Lys His Lys Ile Asp Lys Ser His Glu Phe Ala Leu
 145                 150                 155                 160
 Val Val Val Asn Asp Asp Thr Ala Trp Leu Ser Gly Leu Thr Ser Asp
                 165                 170                 175    
 Pro Arg Glu Leu Cys Ser Cys Leu Tyr Asp Leu Glu Thr Ala Ser Cys
             180                 185                 190        
 Ser Thr Phe Asn Leu Glu Gly Leu Phe Ser Leu Ile Gln Gln Lys Thr
         195                 200                 205            
 Glu Leu Pro Val Thr Glu Asn Val Gln Thr Ile Pro Pro Pro Tyr Val
     210                 215                 220                
 Val Arg Thr Ile Leu Val Tyr Ser Arg Pro Pro Cys Gln Pro Gln Phe
 225                 230                 235                 240
 Ser Leu Thr Glu Pro Met Lys Lys Met Phe Gln Cys Pro Tyr Phe Phe
                 245                 250                 255    
 Phe Asp Val Val Tyr Ile His Asn Gly Thr Glu Glu Lys Glu Glu Glu
             260                 265                 270        
 Met Ser Trp Lys Asp Met Phe Ala Phe Met Gly Ser Leu Asp Thr Lys
         275                 280                 285            
 Gly Thr Ser Tyr Lys Tyr Glu Val Ala Leu Ala Gly Pro Ala Leu Glu
     290                 295                 300                
 Leu His Asn Cys Met Ala Lys Leu Leu Ala His Pro Leu Gln Arg Pro
 305                 310                 315                 320
 Cys Gln Ser His Ala Ser Tyr Ser Leu Leu Glu Glu Glu Asp Glu Ala
                 325                 330                 335    
 Ile Glu Val Glu Ala Thr Val
             340            



      <210> 747
      <211> 128
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(126)
      <223> Xaa = any amino acid or nothing 


      <400> 747
 Asn Leu Ser Ala Ser Phe Leu Val Leu Gly Gly Ala His Arg Gly Asn
   1               5                  10                  15    
 Pro Gly Phe Gln Pro Cys Pro Leu Pro Pro Pro Pro Ala Pro Pro Ile
              20                  25                  30        
 Gln Lys Ser Val Pro Val Ala Trp Gln Xaa Ala Trp Pro Arg Asn Arg
          35                  40                  45            
 Ser Pro Pro Ala Arg Pro His Ile Pro Arg Thr Gln Pro Gln Pro Glu
      50                  55                  60                
 Pro Pro Ser Pro Asp Gln Gln Val Thr Arg Ser Asn Ser Ala Ala Pro
  65                  70                  75                  80
 Ser Gly Arg Leu Ser Asn Pro Gln Cys Pro Arg Ala Leu Arg Gly Gln
                  85                  90                  95    
 Pro Leu Ala Gln Leu Thr Pro Pro Ala Ser Ala Pro Val Pro Ala Val
             100                 105                 110        
 Cys Ser Thr Cys Lys Asn Pro Ala Ser Leu Pro Asp Thr Val
         115                 120                 125    



      <210> 748
      <211> 197
      <212> PRT
      <213> Homo sapiens


      <400> 748
 Lys Gly Leu Ala Pro His Thr Pro His Thr Arg Arg Ser Leu Gly Pro
   1               5                  10                  15    
 Glu Cys Gly Ala Pro Ser Val Ala Arg Pro Gly Arg Pro Gln Pro Ser
              20                  25                  30        
 Pro Leu Leu Met Thr Pro Val Pro Ala Phe Leu Gln Cys Leu Arg Glu
          35                  40                  45            
 Asn Ser Asp Val Lys Thr His Gly Pro Phe Glu Ala Val Met Arg Thr
      50                  55                  60                
 Leu Cys Glu Cys Lys Glu Thr Ala Ser Lys Thr Leu Ser Arg Phe Gly
  65                  70                  75                  80
 Ile Gln Pro Cys Ser Ile Cys Leu Gly Asp Ala Lys Asp Pro Val Cys
                  85                  90                  95    
 Leu Pro Cys Asp His Val His Cys Leu Arg Cys Leu Arg Ala Trp Phe
             100                 105                 110        
 Ala Ser Lys Gln Met Ile Cys Pro Tyr Cys Leu Thr Ala Leu Pro Asp
         115                 120                 125            
 Glu Phe Ser Pro Ala Val Ser Gln Ala His Arg Glu Ala Ile Glu Lys
     130                 135                 140                
 His Ala Arg Phe Arg Gln Met Cys Asn Ser Phe Phe Val Asp Leu Val
 145                 150                 155                 160
 Ser Thr Ile Cys Phe Lys Asp Asn Ala Pro Pro Glu Lys Glu Val Ile
                 165                 170                 175    
 Glu Ser Leu Leu Ser Leu Thr Leu Arg Pro Lys Gly Ala Leu Lys Arg
             180                 185                 190        
 Cys Cys Pro Glu
         195    



      <210> 749
      <211> 169
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(169)
      <223> Xaa = any amino acid or nothing 


      <400> 749
 Phe Pro Thr Ala Met Ser Ser Val Ser Val Val Pro Leu Ala Arg Leu
   1               5                  10                  15    
 Pro Ser Ser Leu Pro Thr Ser Ser His Ser Pro Xaa Ala Glu His Gln
              20                  25                  30        
 Ser Pro Val Thr Trp Pro Pro Ser Val Leu Leu Pro Leu Pro Thr His
          35                  40                  45            
 Ala Gly Pro Arg Arg Thr Ser Cys Pro Ala Pro Thr Thr His Pro Tyr
      50                  55                  60                
 Pro Pro Pro Phe Gln Phe Val Leu Ser Arg Gly Glu Phe Phe Phe Ser
  65                  70                  75                  80
 Gln Arg Leu Pro Pro Leu Arg Thr Asn Pro Thr His Thr Gln Ile Gly
                  85                  90                  95    
 Ser Asp Pro Phe Phe Pro Leu Val Lys His Leu Thr Pro Met Pro Arg
             100                 105                 110        
 Pro Cys Phe Asn Pro Leu Ser His His Val Leu Ser Leu Phe Cys Glu
         115                 120                 125            
 Leu Phe Cys Ile Asn Pro Thr Leu Ser Val Thr Asp Ala Val Ser Glu
     130                 135                 140                
 Gly Gly Gln Asn Thr Asn Phe Ser Arg Glu Asp Phe Trp Ala Met Glu
 145                 150                 155                 160
 Gly Arg Leu Ile His Gly Leu Ile Asn
                 165                



      <210> 750
      <211> 85
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(84)
      <223> Xaa = any amino acid or nothing 


      <400> 750
 Gln Lys Xaa Asp Ile His Asp Tyr Phe Val Ile Val Ser Gly Thr Cys
   1               5                  10                  15    
 Thr Arg His Leu His Ala Met Ala Phe Tyr Val Val Lys Met Tyr Lys
              20                  25                  30        
 His Leu Lys Cys Lys Arg Asp Pro His Val Lys Ile Asp Gly Lys His
          35                  40                  45            
 Thr His Asp Trp Leu Cys Val Asp Ser Arg Arg Met Leu Ile His Leu
      50                  55                  60                
 Met Leu Pro Glu Thr Arg Glu Ile Tyr Glu Leu Glu Lys Leu Ser Thr
  65                  70                  75                  80
 Leu Pro Leu Leu
                



      <210> 751
      <211> 402
      <212> PRT
      <213> Homo sapiens


      <400> 751
 Ser Cys Gly Cys Thr Arg Arg Ser Ala Ala Val Leu Met Ala Arg His
   1               5                  10                  15    
 Gly Leu Pro Leu Leu Pro Leu Leu Ser Leu Leu Val Gly Ala Trp Leu
              20                  25                  30        
 Lys Leu Gly Asn Gly Gln Ala Thr Ser Met Val Gln Leu Gln Gly Gly
          35                  40                  45            
 Arg Phe Leu Met Gly Thr Asn Ser Pro Asp Ser Arg Asp Gly Glu Gly
      50                  55                  60                
 Pro Val Arg Glu Ala Thr Val Lys Pro Phe Ala Ile Asp Ile Phe Pro
  65                  70                  75                  80
 Val Thr Asn Lys Asp Phe Arg Asp Phe Val Arg Glu Lys Lys Tyr Arg
                  85                  90                  95    
 Thr Glu Ala Glu Met Phe Gly Trp Ser Phe Val Phe Glu Asp Phe Val
             100                 105                 110        
 Ser Asp Glu Leu Arg Asn Lys Ala Thr Gln Pro Met Lys Ser Val Leu
         115                 120                 125            
 Trp Trp Leu Pro Val Glu Lys Ala Phe Trp Arg Gln Pro Ala Gly Pro
     130                 135                 140                
 Gly Ser Gly Ile Arg Glu Arg Leu Glu His Pro Val Leu His Val Ser
 145                 150                 155                 160
 Trp Asn Asp Ala Arg Ala Tyr Cys Ala Trp Arg Gly Lys Arg Leu Pro
                 165                 170                 175    
 Thr Glu Glu Glu Trp Glu Phe Ala Ala Arg Gly Gly Leu Lys Val Lys
             180                 185                 190        
 Phe Thr His Gly Gly Thr Gly Ser Ser Gln Thr Ala Pro Thr Cys Gly
         195                 200                 205            
 Arg Glu Ser Ser Pro Arg Glu Thr Lys Leu Arg Met Ala Ser Met Glu
     210                 215                 220                
 Ser Pro Pro Val Asn Ala Phe Pro Ala Gln Asn Asn Tyr Gly Leu Tyr
 225                 230                 235                 240
 Asp Leu Leu Gly Asn Val Trp Glu Trp Thr Ala Ser Pro Tyr Gln Ala
                 245                 250                 255    
 Ala Glu Gln Asp Met Arg Val Leu Arg Gly His Pro Gly Ser Thr Gln
             260                 265                 270        
 Leu Met Ala Leu Pro Ile Thr Gly Pro Gly Ser Pro Pro Gly Trp Ala
         275                 280                 285            
 Thr Leu Gln Ile Gln Pro Gln Thr Thr Ser Val Ser Ala Val Leu Gln
     290                 295                 300                
 Thr Gln Ala Gly Arg Gln Gly Ser Cys Lys Gln Pro Gly Gly Asp Lys
 305                 310                 315                 320
 Glu Lys Ser Leu Leu Gly Ser Leu Ser Phe Pro Gly His Val Ala Asn
                 325                 330                 335    
 Ser Ala Ile Pro Ser Ser Arg Ala Ser Ala Ser Gly Lys Asn Phe Pro
             340                 345                 350        
 Phe Pro Val Ser His Pro Ser Val Ala Gly Ala Ser His Gln Gly Arg
         355                 360                 365            
 Arg Gly Leu Ser Leu Leu Cys Phe Gly Glu Gly Ala Gln Cys Val Leu
     370                 375                 380                
 Thr Met Ala Gly Gly Gln Val Phe Leu Leu Glu Ala Lys Tyr Tyr
 385                 390                 395                



      <210> 752
      <211> 87
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(87)
      <223> Xaa = any amino acid or nothing 


      <400> 752
 Thr Asp Ile Arg Met Thr Met Thr Thr Asp Ser Leu Ser Val Pro Xaa
   1               5                  10                  15    
 His Pro Arg Asp Trp Glu Asn Pro Gly Ala Thr Leu Leu Asn Arg Val
              20                  25                  30        
 Ala Leu His Ser Ser Pro Leu Val Thr Phe His Pro Gly Arg Val Ser
          35                  40                  45            
 Ser Gly Asp Pro Gly Gly Ser Pro Glu Pro Ala Glu Gly Leu Arg Ser
      50                  55                  60                
 Arg Pro Ala Leu Trp Arg Val Gly Ser Glu Ala Pro Ala Leu Ala Asp
  65                  70                  75                  80
 Arg Pro His Asp Leu Gly Leu
                  85        

